2011
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Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
Nature 476 (7359): 214-219 (2011-08-10)
Crochet S; Poulet JFA; Kremer Y; Petersen CCH
Synaptic mechanisms underlying sparse coding of active touch
Neuron 69 (6): 1160-1175 (2011-03-24)
McDermott-Roe C; Ye J; Ahmed R; Sun XM; Serafin A; Ware J; Bottolo L; Muckett P; Canas X; Zhang J; Rowe GC; Buchan R; Lu H; Braithwaite A; Mancini M; Hauton D; Marti R; Garcia-Arumi E; Hubner N; Jacob H; Serikawa T; Zidek V; Papousek F; Kolar F; Cardona M; Ruiz-Meana M; Garcia-Dorado D; Comella JX; Felkin LE; Barton PJ; Arany Z; Pravenec M; Petretto E; Sanchis D; Cook SA
Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function
Nature 478 (7367): 114-118 (2011-10-06)
von Eyss B; Maaskola J; Memczak S; Moellmann K; Schuetz A; Loddenkemper C; Tanh MD; Otto A; Muegge K; Heinemann U; Rajewsky N; Ziebold U
The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation
EMBO Journal 31 (4): 972-985 (2011-12-13)
Maier N; Tejero-Cantero A; Dorrn AL; Winterer J; Beed PS; Morris G; Kempter R; Poulet JFA; Leibold C; Schmitz D
Coherent phasic excitation during hippocampal ripples
Neuron 72 (1): 137-152 (2011-10-06)
Rehm A; Mensen A; Schradi K; Gerlach K; Wittstock S; Winter S; Buechner G; Doerken B; Lipp M; Hoepken UE
Cooperative function of CCR7 and lymphotoxin in the formation of a lymphoma-permissive niche within murine secondary lymphoid organs
Blood 118 (4): 1020-1033 (2011-07-28)
Pless O; Kowenz-Leutz E; Dittmar G; Leutz A
A differential proteome screening system for post-translational modification-dependent transcription factor interactions
Nature Protocols 6 (3): 359-364 (2011-02)
Sanchez M; Galy B; Schwanhaeusser B; Blake J; Baehr-Ivacevic T; Benes V; Selbach M; Muckenthaler MU; Hentze MW
Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by IRPs
Blood 118 (22): e168-e179 (2011-11-24)
Kettenmann H; Hanisch UK; Noda M; Verkhratsky A
Physiology of microglia
Physiological Reviews 91 (2): 461-553 (2011-04)
Unwin RJ; Luft FC; Shirley DG
Pathophysiology and management of hypokalemia: a clinical perspective
Nature Reviews Nephrology 7 (2): 75-84 (2011-02)
Lebedeva S; Jens M; Theil K; Schwanhaeusser B; Selbach M; Landthaler M; Rajewsky N
Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR
Molecular Cell 43 (3): 340-352 (2011-08-05)
Granata A; Koo SJ; Haucke V; Schiavo G; Warner TT
CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process
EMBO Journal 30 (1): 181-193 (2011-01-05)
Hoppmann C; Schmieder P; Domaing P; Vogelreiter G; Eichhorst J; Wiesner B; Morano I; Rueck-Braun K; Beyermann M
Photocontrol of contracting muscle fibers
Angewandte Chemie International Edition 50 (33): 7699-7702 (2011-08-08)
Anders K; Buschow C; Herrmann A; Milojkovic A; Loddenkemper C; Kammertoens T; Daniel P; Yu H; Charo J; Blankenstein T
Oncogene-targeting T cells reject large tumors while oncogene inactivation selects escape variants in mouse models of cancer
Cancer Cell 20 (6): 755-767 (2011-12-13)
Leisle L; Ludwig CF; Wagner FA; Jentsch TJ; Stauber T
ClC-7 is a slowly voltage-gated 2Cl(-)/1H(+)-exchanger and requires Ostm1 for transport activity
EMBO Journal 30 (11): 2140-2152 (2011-06-01)
Haufe S; Engeli S; Kast P; Boehnke J; Utz W; Haas V; Hermsdorf M; Maehler A; Wiesner S; Birkenfeld AL; Sell H; Otto C; Mehling H; Luft FC; Eckel J; Schulz-Menger J; Boschmann M; Jordan J
Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects
Hepatology 53 (5): 1504-1514 (2011-05)
Gangadharan V; Wang R; Ulzhoefer B; Luo C; Bardoni R; Bali KK; Agarwal N; Tegeder I; Hildebrandt U; Nagy GG; Todd AJ; Ghirri A; Haeussler A; Sprengel R; Seeburg PH; Macdermott AB; Lewin GR; Kuner R
Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice
Journal of Clinical Investigation 121 (4): 1608-1623 (2011-04-01)
Zhang X; Yalcin S; Lee DF; Yeh TY; Lee SM; Su J; Mungamuri SK; Rimmele P; Kennedy M; Sellers R; Landthaler M; Tuschl T; Chi NW; Lemischka I; Keller G; Ghaffari S
FOXO1 is an essential regulator of pluripotency in human embryonic stem cells
Nature Cell Biology 13 (9): 1092-1099 (2011-07-31)
Hu H; Eggers K; Chen W; Garshasbi M; Motazacker MM; Wrogemann K; Kahrizi K; Tzschach A; Hosseini M; Bahman I; Hucho T; Muehlenhoff M; Gerardy-Schahn R; Najmabadi H; Ropers HH; Kuss AW
ST3GAL3 mutations impair the development of higher cognitive functions
American Journal of Human Genetics 89 (3): 407-414 (2011-09-09)
Ghani S; Riemke P; Schoenheit J; Lenze D; Stumm J; Hoogenkamp M; Lagendijk A; Heinz S; Bonifer C; Bakkers J; Abdelilah-Seyfried S; Hummel M; Rosenbauer F
Macrophage development from hematopoietic stem cells requires PU.1 coordinated microRNA expression
Blood 118 (8): 2275-2284 (2011-08-25)
Nogai H; Doerken B; Lenz G
Pathogenesis of non-Hodgkin's lymphoma
Journal of Clinical Oncology 29 (14): 1803-1811 (2011-05-10)
Lechner SG; Markworth S; Poole K; Smith ES; Lapatsina L; Frahm S; May M; Pischke S; Suzuki M; Ibanez-Tallon I; Luft FC; Jordan J; Lewin GR
The molecular and cellular identity of peripheral osmoreceptors
Neuron 69 (2): 332-344 (2011-01-27)
Brembeck FH; Wiese M; Zatula N; Grigoryan T; Dai Y; Fritzmann J; Birchmeier W
BCL9-2 promotes early stages of intestinal tumor progression
Gastroenterology 141 (4): 1359-1370 (2011-10)
Tursun B; Patel T; Kratsios P; Hobert O
Direct conversion of C. elegans germ cells into specific neuron types
Science 331 (6015): 304-308 (2011-01-21)
Popovic J; Li LP; Kloetzel PM; Leisegang M; Uckert W; Blankenstein T
The only proposed T-cell epitope derived from the TEL-AML1 translocation is not naturally processed
Blood 118 (4): 946-954 (2011-07-28)
Dees C; Akhmetshina A; Zerr P; Reich N; Palumbo K; Horn A; Juengel A; Beyer C; Kroenke G; Zwerina J; Reiter R; Alenina N; Maroteaux L; Gay S; Schett G; Distler O; Distler JH
Platelet-derived serotonin links vascular disease and tissue fibrosis
Journal of Experimental Medicine 208 (5): 961-972 (2011-05-09)
Birchmeier W
Stem cells: Orphan receptors find a home
Nature 476 (7360): 287-288 (2011-08-18)
Le Coutre P; Rea D; Abruzzese E; Dombret H; Trawinska MM; Herndlhofer S; Doerken B; Valent P
Severe peripheral arterial disease during nilotinib therapy
Journal of the National Cancer Institute 103 (17): 1347-1348 (2011-09-07)
Vaegter CB; Jansen P; Fjorback AW; Glerup S; Skeldal S; Kjolby M; Richner M; Erdmann B; Nyengaard JR; Tessarollo L; Lewin GR; Willnow TE; Chao MV; Nykjaer A
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling
Nature Neuroscience 14 (1): 54-61 (2011-01)
Heidenreich M; Lechner SG; Vardanyan V; Wetzel C; Cremers CW; De Leenheer EM; Aranguez G; Moreno-Pelayo MA; Jentsch TJ; Lewin GR
KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man
Nature Neuroscience 15 (1): 138-145 (2011-11-20)
Schuetze M; Boeing H; Pischon T; Rehm J; Kehoe T; Gmel G; Olsen A; Tjonneland AM; Dahm CC; Overvad K; Clavel-Chapelon F; Boutron-Ruault MC; Trichopoulou A; Benetou V; Zylis D; Kaaks R; Rohrmann S; Palli D; Berrino F; Tumino R; Vineis P; Rodriguez L; Agudo A; Sanchez MJ; Dorronsoro M; Chirlaque MD; Barricarte A; Peeters PH; van Gils CH; Khaw KT; Wareham N; Allen NE; Key TJ; Boffetta P; Slimani N; Jenab M; Romaguera D; Wark PA; Riboli E; Bergmann MM
Alcohol attributable burden of incidence of cancer in eight European countries based on results from prospective cohort study
British Medical Journal 342: d1584 (2011-04-07)
Smith ES; Omerbasic D; Lechner SG; Anirudhan G; Lapatsina L; Lewin GR
The molecular basis of acid insensitivity in the African naked mole-rat
Science 334 (6062): 1557-1560 (2011-12-16)
Chiang LY; Poole K; Oliveira BE; Duarte N; Bernal Sierra YA; Bruckner-Tuderman L; Koch M; Hu J; Lewin GR
Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons
Nature Neuroscience 14 (8): 993-1000 (2011-07-03)
van Duijnhoven FJ; Bueno-De-Mesquita HB; Calligaro M; Jenab M; Pischon T; Jansen EH; Frohlich J; Ayyobi A; Overvad K; Toft-Petersen AP; Tjonneland A; Hansen L; Boutron-Ruault MC; Clavel-Chapelon F; Cottet V; Palli D; Tagliabue G; Panico S; Tumino R; Vineis P; Kaaks R; Teucher B; Boeing H; Drogan D; Trichopoulou A; Lagiou P; Dilis V; Peeters PH; Siersema PD; Rodriguez L; Gonzalez CA; Molina-Montes E; Dorronsoro M; Tormo MJ; Barricarte A; Palmqvist R; Hallmans G; Khaw KT; Tsilidis KK; Crowe FL; Chajes V; Fedirko V; Rinaldi S; Norat T; Riboli E
Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition
Gut 60 (8): 1094-1102 (2011-08)
Biton M; Levin A; Slyper M; Alkalay I; Horwitz E; Mor H; Kredo-Russo S; Avnit-Sagi T; Cojocaru G; Zreik F; Bentwich Z; Poy MN; Artis D; Walker MD; Hornstein E; Pikarsky E; Ben-Neriah Y
Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk
Nature Immunology 12 (3): 239-246 (2011-03)
Jing H; Kase J; Doerr JR; Milanovic M; Lenze D; Grau M; Beuster G; Ji S; Reimann M; Lenz P; Hummel M; Doerken B; Lenz G; Scheidereit C; Schmitt CA; Lee S
Opposing roles of NF-{kappa}B in anti-cancer treatment outcome unveiled by cross-species investigations
Genes & Development 25 (20): 2137-2146 (2011-10-15)
Somel M; Liu X; Tang L; Yan Z; Hu H; Guo S; Jiang X; Zhang X; Xu G; Xie G; Li N; Hu Y; Chen W; Paeaebo S; Khaitovich P
MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primates
PLoS Biology 9 (12): e1001214 (2011-12)
Nemoto Y; Kanai T; Shinohara T; Ito T; Nakamura T; Okamoto R; Tsuchiya K; Lipp M; Eishi Y; Watanabe M
Luminal CD4 + T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation
Gastroenterology 141 (6): 2130-2139.e11 (2011-12)
Drenckhahn JD
Heart development: mitochondria in command of cardiomyocyte differentiation
Developmental Cell 21 (3): 392-393 (2011-09-13)
Billig GM; Pal B; Fidzinski P; Jentsch TJ
Ca(2+)-activated Cl(-) currents are dispensable for olfaction
Nature Neuroscience 14 (6): 763-769 (2011-06)
Frahm S; Slimak MA; Ferrarese L; Santos-Torres J; Antolin-Fontes B; Auer S; Filkin S; Pons S; Fontaine JF; Tsetlin V; Maskos U; Ibanez-Tallon I
Aversion to nicotine is regulated by the balanced activity of beta4 and alpha5 nicotinic receptor subunits in the medial habenula
Neuron 70 (3): 522-535 (2011-05-12)
Adamidi C; Wang Y; Gruen D; Mastrobuoni G; You X; Tolle D; Dodt M; Mackowiak SD; Gogol-Doering A; Oenal P; Rybak A; Ross E; Alvarado AS; Kempa S; Dieterich C; Rajewsky N; Chen W
De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics
Genome Research 21 (7): 1193-1200 (2011-07)
Aleksandrova K; Pischon T; Weikert C
Urinary sodium excretion and cardiovascular disease mortality
JAMA: Journal of the American Medical Association 306 (10): 1083 (2011-09-14)
Cui Y; Niziolek PJ; Macdonald BT; Zylstra CR; Alenina N; Robinson DR; Zhong Z; Matthes S; Jacobsen CM; Conlon RA; Brommage R; Liu Q; Mseeh F; Powell DR; Yang QM; Zambrowicz B; Gerrits H; Gossen JA; He X; Bader M; Williams BO; Warman ML; Robling AG
Lrp5 functions in bone to regulate bone mass
Nature Medicine 17 (6): 684-691 (2011-06)
Ivics Z; Izsvak Z; Medrano G; Chapman KM; Hamra FK
Sleeping Beauty transposon mutagenesis in rat spermatogonial stem cells
Nature Protocols 6 (10): 1521-1535 (2011-10)
Paragas N; Qiu A; Zhang Q; Samstein B; Deng SX; Schmidt-Ott KM; Viltard M; Yu W; Forster CS; Gong G; Liu Y; Kulkarni R; Mori K; Kalandadze A; Ratner AJ; Devarajan P; Landry DW; D'Agati V; Lin CS; Barasch J
The Ngal reporter mouse detects the response of the kidney to injury in real time
Nature Medicine 17 (2): 216-222 (2011-02)
Jungkamp AC; Stoeckius M; Mecenas D; Gruen D; Mastrobuoni G; Kempa S; Rajewsky N
In vivo and transcriptome-wide identification of RNA binding protein target sites
Molecular Cell 44 (5): 828-840 (2011-12-09)
Schwanhaeusser B; Busse D; Li N; Dittmar G; Schuchhardt J; Wolf J; Chen W; Selbach M
Global quantification of mammalian gene expression control
Nature 473 (7347): 337-342 (2011-05-19)
Steininger A; Moebs M; Ullmann R; Koechert K; Kreher S; Lamprecht B; Anagnostopoulos I; Hummel M; Richter J; Beyer M; Janz M; Klemke CD; Stein H; Doerken B; Sterry W; Schrock E; Mathas S; Assaf C
Genomic loss of the putative tumor suppressor gene E2A in human lymphoma
Journal of Experimental Medicine 208 (8): 1585-1593 (2011-08-01)
Gao S; von der Malsburg A; Dick A; Faelber K; Schroeder GF; Haller O; Kochs G; Daumke O
Structure of Myxovirus resistance protein A reveals intra- and intermolecular domain interactions required for the antiviral function
Immunity 35 (4): 514-525 (2011-10-28)
Najmabadi H; Hu H; Garshasbi M; Zemojtel T; Abedini SS; Chen W; Hosseini M; Behjati F; Haas S; Jamali P; Zecha A; Mohseni M; Puettmann L; Vahid LN; Jensen C; Moheb LA; Bienek M; Larti F; Mueller I; Weissmann R; Darvish H; Wrogemann K; Hadavi V; Lipkowitz B; Esmaeeli-Nieh S; Wieczorek D; Kariminejad R; Firouzabadi SG; Cohen M; Fattahi Z; Rost I; Mojahedi F; Hertzberg C; Dehghan A; Rajab A; Banavandi MJS; Hoffer J; Falah M; Musante L; Kalscheuer V; Ullmann R; Kuss AW; Tzschach A; Kahrizi K; Ropers HH
Deep sequencing reveals 50 novel genes for recessive cognitive disorders
Nature 478 (7367): 57-63 (2011-10-06)
Faelber K; Posor Y; Gao S; Held M; Roske Y; Schulze D; Haucke V; Noe F; Daumke O
Crystal structure of nucleotide-free dynamin
Nature 477 (7366): 556-560 (2011-09-29)
Stuiver M; Lainez S; Will C; Terryn S; Guenzel D; Debaix H; Sommer K; Kopplin K; Thumfart J; Kampik NB; Querfeld U; Willnow TE; Nemec V; Wagner CA; Hoenderop JG; Devuyst O; Knoers NV; Bindels RJ; Meij IC; Mueller D
CNNM2, encoding a basolateral protein required for renal Mg(2+) handling, is mutated in dominant hypomagnesemia
American Journal of Human Genetics 88 (3): 333-343 (2011-03-11)
Leddin M; Perrod C; Hoogenkamp M; Ghani S; Assi S; Heinz S; Wilson NK; Follows G; Schoenheit J; Vockentanz L; Mosamam A; Chen W; Tenen DG; Westhead DR; Goettgens B; Bonifer C; Rosenbauer F
Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells
Blood 117 (10): 2827-2838 (2011-03-10)
Borchmann P; Haverkamp H; Diehl V; Cerny T; Markova J; Ho AD; Eich HT; Mueller-Hermelink HK; Kanz L; Greil R; Rank A; Paulus U; Smardova L; Huber C; Doerken B; Nerl C; Krause SW; Mueller RP; Fuchs M; Engert A
Eight cycles of escalated-dose BEACOPP compared with four cycles of escalated-dose BEACOPP followed by four cycles of baseline-dose BEACOPP with or without radiotherapy in patients with advanced-stage Hodgkin's lymphoma: final analysis of the HD12 trial of the German Hodgkin study group
Journal of Clinical Oncology 29 (32): 4234-4342 (2011-11-10)
Sack U; Walther W; Scudiero D; Selby M; Kobelt D; Lemm M; Fichtner I; Schlag PM; Shoemaker RH; Stein U
Novel effect of antihelminthic niclosamide on S100A4-mediated metastatic progression in colon cancer
Journal of the National Cancer Institute 103 (13): 1018-1036 (2011-07-06)
Blaydon DC; Biancheri P; Di WL; Plagnol V; Cabral RM; Brooke MA; van Heel DA; Ruschendorf F; Toynbee M; Walne A; O'Toole EA; Martin JE; Lindley K; Vulliamy T; Abrams DJ; MacDonald TT; Harper JI; Kelsell DP
Inflammatory skin and bowel disease linked to ADAM17 deletion
New England Journal of Medicine 365 (16): 1502-1508 (2011-10-20)
Trichopoulos D; Bamia C; Lagiou P; Fedirko V; Trepo E; Jenab M; Pischon T; Noethlings U; Overved K; Tjonneland A; Outzen M; Clavel-Chapelon F; Kaaks R; Lukanova A; Boeing H; Aleksandrova K; Benetou V; Zylis D; Palli D; Pala V; Panico S; Tumino R; Sacerdote C; Bueno-De-Mesquita HB; Van Kranen HJ; Peeters PH; Lund E; Quiros JR; Gonzalez CA; Sanchez Perez MJ; Navarro C; Dorronsoro M; Barricarte A; Lindkvist B; Regner S; Werner M; Hallmans G; Khaw KT; Wareham N; Key T; Romieu I; Chuang SC; Murphy N; Boffetta P; Trichopoulou A; Riboli E
Hepatocellular carcinoma risk factors and disease burden in a European cohort: a nested case-control study
Journal of the National Cancer Institute 103 (22): 1686-1695 (2011-11-16)
Tattikota SG; Poy MN
Re-dicing the pancreatic beta-cell: do microRNAs define cellular identity?
EMBO Journal 30 (5): 797-799 (2011-03-02)