Publikationen
2010
Kuhn M; Campillos M; Letunic I; Jensen LJ; Bork P
A side effect resource to capture phenotypic effects of drugs
Molecular Systems Biology 6: 343 (2010)
Jensen LJ; Bork P
Ontologies in quantitative biology: a basis for comparison, integration, and discovery
PLoS Biology 8 (5): e1000374 (2010-05-25)
2009
Gianoulis TA; Raes J; Patel PV; Bjornson R; Korbel JO; Letunic I; Yamada T; Paccanaro A; Jensen LJ; Snyder M; Bork P; Gerstein MB
Quantifying environmental adaptation of metabolic pathways in metagenomics
Proceedings of the National Academy of Sciences of the United States of America 106 (5): 1374-1379 (2009-02-03)
2008
Jensen LJ; Bork P
Biochemistry. Not comparable, but complementary
Science 322 (5898): 56-57 (2008-10-03)
Campillos M; Kuhn M; Gavin AC; Jensen LJ; Bork P
Drug target identification using side-effect similarity
Science 321 (5886): 263-266 (2008-07-11)
2007
Linding R; Jensen LJ; Ostheimer GJ; van Vugt MA; Jorgensen C; Miron IM; Diella F; Colwill K; Taylor L; Elder K; Metalnikov P; Nguyen V; Pasculescu A; Jin J; Park JG; Samson LD; Woodgett JR; Russell RB; Bork P; Yaffe MB; Pawson T
Systematic discovery of in vivo phosphorylation networks
Cell 129 (7): 1415-1426 (2007-06-29)
Zdobnov EM; Bork P
Quantification of insect genome divergence
Trends in Genetics 23: 16-20 (2007-01-01)
Harrington ED; Singh AH; Doerks T; Letunic I; von Mering C; Jensen LJ; Raes J; Bork P
Quantitative assessment of protein function prediction from metagenomics shotgun sequences
Proceedings of the National Academy of Sciences of the United States of America 104 (35): 13913-13918 (2007-08-28)
Soederhaell C; Marenholz I; Kerscher T; Rueschendorf F; Esparza-Gordillo J; Worm M; Gruber C; Mayr G; Albrecht M; Rohde K; Schulz H; Wahn U; Huebner N; Lee YA
Variants in a novel epidermal collagen gene (COL29A1) are associated with atopic dermatitis
PLoS Biology 5 (9): 1952-1961 (2007-09)
Lee-Kirsch MA; Gong M; Chowdhury D; Senenko L; Engel K; Lee YA; de Silva U; Bailey SL; Witte T; Vyse TJ; Kere J; Pfeiffer C; Harvey S; Wong A; Koskenmies S; Hummel O; Rohde K; Schmidt RE; Dominiczak AF; Gahr M; Hollis T; Perrino FW; Lieberman J; Huebner N
Mutations in the gene encoding the 3-5 DNA exonuclease TREX1 are associated with systemic lupus erythematosus
Nature Genetics 39 (9): 1065-1067 (2007-09)
2006
Yanai I; Korbel JO; Boue S; McWeeney SK; Bork P; Lercher MJ
Similar gene expression profiles do not imply similar tissue functions
Trends in Genetics 22: 132-138 (2006-02-08)
Ciccarelli FD; Doerks T; von Mehring C; Creevey CJ; Snel B; Bork P
Toward automatic reconstruction of a highly resolved tree of life
Science 311 (5765): 1283-1287 (2006-03-03)
Jensen LJ; Saric J; Bork P
Literature mining for the biologist: from information retrieval to biological discovery
Nature Reviews Genetics 7: 119-129 (2006-02-01)
Honeybee Genome Sequencing Consortium
Insights into social insects from the genome of the honeybee Apis mellifera
Nature 443: 931-949 (2006-10-26)
Witt H; Sahin-Toth M; Landt O; Chen JM; Kaehne T; Drenth JP; Kukor Z; Szepessy E; Halangk W; Dahm S; Rohde K; Schulz HU; Le Marechal C; Akar N; Ammann RW; Truninger K; Bargetzi M; Bhatia E; Castellani C; Cavestro GM; Cerny M; stro-Bisol G; Spedini G; Eiberg H; Jansen JB; Koudova M; Rausova E; Macek M; Malats N; Real FX; Menzel HJ; Moral P; Galavotti R; Pignatti PF; Rickards O; Spicak J; Zarnescu NO; Boeck W; Gress TM; Friess H; Ockenga J; Schmidt H; Pfuetzer R; Loehr M; Simon P; Weiss FU; Lerch MM; Teich N; Keim V; Berg T; Wiedenmann B; Luck W; Groneberg DA; Becker M; Keil T; Kage A; Bernardova J; Braun M; Gueldner C; Halangk J; Rosendahl J; Witt U; Treiber M; Nickel R; Ferec C
A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis
Nature Genetics 38: 668-673 (2006-05-14)
Jensen LJ; Jensen TS; de Lichtenberg U; Brunak S; Bork P
Co-evolution of transcriptional and post-translational cell-cycle regulation
Nature 443: 594-597 (2006-10-05)
2005
Ciccarelli FD; von Mering C; Suyama M; Harrington ED; Izaurralde E; Bork P
Complex genomic rearrangements lead to novel primate gene function
Genome Research 15: 343-351 (2005-01-01)
Nothnagel M; Rohde K
The effect of single-nucleotide polymorphism marker selection on patterns of haplotype blocks and haplotype frequency estimates
American Journal of Human Genetics 77 (6): 988-998 (2005-12-01)
Korbel JO; Doerks T; Jensen LJ; Perez-Iratxeta C; Kaczanowski S; Hooper SD; Andrade MA; Bork P
Systematic association of genes to phenotypes by genome and literature mining
PLoS Biology 3 (5): e134 (2005-04-05)
Mikkelsen TS; Hillier LW; Eichler EE; Zody MC; Jaffe DB; Yang SP; Enard W; Hellmann I; Lindblad-Toh K; Altheide TK; Archidiacono N; Bork P; Butler J; Chang JL; Cheng Z; Chinwalla AT; de Jong P; Delehaunty KD; Fronick CC; Fulton LL; Gilad Y; Glusman G; Gnerre S; Graves TA; Hayakawa T; Hayden KE; Huang XQ; Ji HK; Kent WJ; King MC; Kulbokas EJ; Lee MK; Liu G; Lopez-Otin C; Makova KD; Man O; Mardis ER; Mauceli E; Miner TL; Nash WE; Nelson JO; Paeaebo S; Patterson NJ; Pohl CS; Pollard KS; Pruefer K; Puente XS; Reich D; Rocchi M; Rosenbloom K; Ruvolo M; Richter DJ; Schaffner SF; Smit AFA; Smith SM; Suyama M; Taylor J; Torrents D; Tuzun E; Varki A; Velasco G; Ventura M; Wallis JW; Wendl MC; Wilson RK; Lander ES; Waterston RH
Initial sequence of the chimpanzee genome and comparison with the human genome
Nature 437 (7055): 69-87 (2005-09-01)
de Lichtenberg U; Jensen LJ; Brunak S; Bork P
Dynamic complex formation during the yeast cell cycle
Science 307 (5710): 724-727 (2005-02-04)
Reinhard C; Meyer B; Fuchs H; Stoeger T; Eder G; Rueschendorf F; Heyder J; Nuernberg P; Hrabe de Angelis M; Schulz H
Genomewide linkage analysis identifies novel genetic loci for lung function in mice
American Journal of Respiratory and Critical Care Medicine 171: 880-888 (2005-01-07)
2004
Doerks T; Andrade MA; Lathe W; von Mering C; Bork P
Global analysis of bacterial transcription factors to predict cellular target processes
Trends in Genetics 20: 126-131 (2004-01-01)
Korbel JO; Jensen LJ; von Mering C; Bork P
Analysis of genomic context: prediction of functional associations from conserved bidirectionally transcribed gene pairs
Nature Biotechnology 22: 911-917 (2004-07-01)
Dandekar T
Trends in biochemical systems : Computational analysis of biochemical systems
Trends in Biochemical Sciences 26: 637 (2004-01-01)
Hillier LW; Miller W; Birney E; Warren W; Hardison RC; Ponting CP; Bork P; Burt DW; Groenen MAM; Delany ME; Dodgson JB; Chinwalla AT; Cliften PF; Clifton SW; Delehaunty KD; Fronick C; Fulton RS; Graves TA; Kremitzki C; Layman D; Magrini V; McPherson JD; Miner TL; Minx P; Nash WE; Nhan MN; Nelson JO; Oddy LG; Pohl CS; Randall-Maher J; Smith SM; Wallis JW; Yang SP; Romanov MN; Rondelli CM; Paton B; Smith J; Morrice D; Daniels L; Tempest HG; Robertson L; Masabanda JS; Griffin DK; Vignal A; Fillon V; Jacobbson L; Kerje S; Andersson L; Crooijmans RPM; Aerts J; van der Poel JJ; Ellegren H; Caldwell RB; Hubbard SJ; Grafham DV; Kierzek AM; McLaren SR; Overton IM; Arakawa H; Beattie KJ; Bezzubov Y; Boardman PE; Bonfield JK; Croning MDR; Davies RM; Francis MD; Humphray SJ; Scott CE; Taylor RG; Tickle C; Brown WRA; Rogers J; Buerstedde JM; Wilson SA; Stubbs L; Ovcharenko I; Gordon L; Lucas S; Miller MM; Inoko H; Shiina T; Kaufman J; Salomonsen J; Skjoedt K; Wong GKS; Wang J; Liu B; Wang J; Yu J; Yang HM; Nefedov M; Koriabine M; de Jong PJ; Goodstadt L; Webber C; Dickens NJ; Letunic I; Suyama M; Torrents D; von Mering C; Zdobnov EM; Makova K; Nekrutenko A; Elnitski L; Eswara P; King DC; Yang S; Tyekucheva S; Radakrishnan A; Harris RS; Chiaromonte F; Taylor J; He JB; Rijnkels M; Griffiths-Jones S; Ureta-Vidal A; Hoffman MM; Severin J; Searle SMJ; Law AS; Speed D; Waddington D; Cheng Z; Tuzun E; Eichler E; Bao ZR; Flicek P; Shteynberg DD; Brent MR; Bye JM; Huckle EJ; Chatterji S; Dewey C; Pachter L; Kouranov A; Mourelatos Z; Hatzigeorgiou AG; Paterson AH; Ivarie R; Brandstrom M; Axelsson E; Backstrom N; Berlin S; Webster MT; Pourquie O; Reymond A; Ucla C; Antonarakis SE; Long MY; Emerson JJ; Betran E; Dupanloup I; Kaessmann H; Hinrichs AS; Bejerano G; Furey TS; Harte RA; Raney B; Siepel A; Kent WJ; Haussler D; Eyras E; Castelo R; Abril JF; Castellano S; Camara F; Parra G; Guigo R; Bourque G; Tesler G; Pevzner PA; Smit A; Fulton LA; Mardis ER; Wilson RK
Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
Nature 432 (7018): 695-716 (2004-12-09)
Brinkmann D; Ryan A; Ayhan A; McCluggage WG; Feakins R; Santibanez-Koref MF; Mein CA; Gayther SA; Jacobs IJ
A molecular genetic and statistical approach for the diagnosis of dual-site cancers
Journal of the National Cancer Institute 96: 1441-1446 (2004-01-01)
Hermjakob H; Montecchi-Palazzi L; Bader G; Wojcik R; Salwinski L; Ceol A; Moore S; Orchard S; Sarkans U; von Mering C; Roechert B; Poux S; Jung E; Mersch H; Kersey P; Lappe M; Li YX; Zeng R; Rana D; Nikolski M; Husi H; Brun C; Shanker K; Grant SGN; Sander C; Bork P; Zhu WM; Pandey A; Brazma A; Jacq B; Vidal M; Sherman D; Legrain P; Cesareni G; Xenarios L; Eisenberg D; Steipe B; Hogue C; Apweiler R
The HUPO PSI's Molecular Interaction format - a community standard for the representation of protein interaction data
Nature Biotechnology 22: 177-183 (2004-01-01)
Harrington ED; Boue S; Valcarcel J; Reich JG; Bork P
Estimating rates of alternative splicing in mammals and invertebrates
Nature Genetics 36: 916-917 (2004-01-01)
2003
Gong M; Zhang HY; Schulz H; Lee YA; Sun K; Baehring S; Luft FC; Nuernberg P; Reis A; Rohde K; Ganten D; Hui RT; Huebner N
Genome-wide linkage reveals a locus for human essential (primary) hypertension on chromosome 12p
Human Molecular Genetics 12: 1273-1277 (2003-01-01)
Morett E; Korbel J; Rajan E; Saab-Rincon G; Olvera L; Olvera M; Steffen S; Snel B; Bork P
Systematic discovery of analogous enzymes in thiamin biosynthesis
Nature Biotechnology 21: 790-795 (2003-01-01)
Schmidt S; Sunyaev S; Bork P; Dandekar T
Metabolites: a helping hand for pathway evolution?
Trends in Biochemical Sciences 28: 336-341 (2003-01-01)
Jensen LJ; Ussery DW; Brunak S
Functionality of system components: conservation of protein function in protein feature space
Genome Research 13: 2444-2449 (2003-11-01)
von Mering C; Zdobnov EM; Tsoka S; Ciccarelli FD; Pereira-Leal JB; Ouzounis CA; Bork P
Genome evolution reveals biochemical networks and functional modules
Proceedings of the National Academy of Sciences of the United States of America 100: 15428-15433 (2003-01-01)
Dandekar T
Computational analysis of biochemical systems (book review)
Trends in Biochemical Sciences 26: 637-637 (2003-01-01)
Sunyaev S; Kondrashov FA; Bork P; Ramensky V
Impact of selection, mutation rate and genetic drift on human genetic variation
Human Molecular Genetics 12: 3325-3330 (2003-01-01)
Ciccarelli FD; Bork P; Kerkhoff E
The KIND module: a putative signalling domain evolved from the C lobe of the protein kinase fold
Trends in Biochemical Sciences 28: 349-352 (2003-01-01)
Kriventseva EV; Koch I; Apweiler R; Vingron M; Bork P; Gelfand MS; Sunyaev S
Increase of functional diversity by alternative splicing
Trends in Genetics 19: 124-128 (2003-01-01)
2002
Ciccarelli FD; Doerks T; Bork P
AMOP, a protein module aternativelly spliced in cancer cells
Trends in Biochemical Sciences 27: 113-115 (2002-01-01)
Perez-Iratxeta C; Andrade MA
Worldwide scientific publishing activity
Science 297: 519-519 (2002-01-01)
Reich J
Embryonic stem cells - The debate in Germany
Science 296 (5566): 265-265 (2002-01-01)
Duetsch G; Illig T; Loesgen S; Rohde K; Klopp N; Herbon N; Gohlke H; Altmueller J; Wjst M
STAT6 as an asthma candidate gene: polymorphism-screening, association and haplotype analysis in a Caucasian sib-pair study
Human Molecular Genetics 11: 613-621 (2002-01-01)
Ciccarelli FD; Copley RR; Doerks T; Russell RB; Bork P
CASH - a beta-helix domain widespread among carbohydrate-binding proteins
Trends in Biochemical Sciences 27: 59-62 (2002-01-01)
von Mering C; Bork P
Genome organization: Teamed up for transcription
Nature 417 (6891): 797-798 (2002-01-01)
Sunyaev SR; Lathe W; Bork P
Integration of genome data and protein structures: prediction of protein folds, protein interactions and 'molecular phenotypes' of single nucleotide polymorphisms (Reprinted from Current Opinion in Structural Biology, vol 11, pg 125-130, 2001)
Trends in Genetics Suppl. March: S19-S24 (2002-01-01)
Perez-Iratxeta C; Bork P; Andrade MA
Association of genes to genetically inherited diseases using data mining
Nature Genetics 31: 316-319 (2002-01-01)
Doerks T; Copley RR; Schultz J; Ponting CP; Bork P
Systematic identification of novel protein domain families associated with nuclear functions
Genome Research 12: 47-56 (2002-01-01)
Brett D; Pospisil H; Valcarel J; Reich J; Bork P
Alternative splicing and genome complexity
Nature Genetics 30 (1): 29-30 (2002-01-01)
Doerks T; Huber S; Buchner E; Bork P
BSD: a novel domain in transcription factors and synapse-associated proteins
Trends in Biochemical Sciences 27: 168-170 (2002-04-01)
Knoblauch H; Bauerfeind A; Kraehenbuehl C; Daury A; Rohde K; Bejanin S; Essioux L; Schuster H; Luft FC; Reich J
Common haplotypes in five genes influence genetic variance of LDL and HDL cholesterol in the general population
Human Molecular Genetics 11 (12): 1477-1485 (2002-01-01)
Stelling J; Klamt S; Bettenbrock K; Schuster S; Gilles ED
Metabolic network structure determines key aspects of functionality and regulation
Nature 420 (6912): 190-193 (2002-11-14)
Mott R; Schultz J; Bork P; Ponting CP
Predicting protein cellular localization using a domain projection method
Genome Research 12: 1168-1174 (2002-08-01)
Schuermann MJ; Otto E; Becker A; Saar K; Rueschendorf F; Polak BC; Ala-Mello S; Hoefele J; Wiedensohler A; Haller M; Omran H; Nuernberg P; Hildebrandt F
Mapping of gene loci for nephronophthisis type 4 and Senior-Loken syndrome, to chromosome 1p36
American Journal of Human Genetics 70 (5): 1240-1246 (2002-01-01)
2001
Vanita A; Singh JR; Sarhadi VK; Singh D; Reis A; Rueschendorf F; Becker-Follmann J; Jung M; Sperling K
A novel form of "central pouchlike" cataract, with sutural opacities, maps to chromosome 15q21-22
American Journal of Human Genetics 68 (2): 509-514 (2001-02)
Pfeiffer T; Schuster S; Bonhoeffer S
Cooperation and competition in the evolution of ATP-producing pathways
Science 292: 504-507 (2001-01-01)
Doerks T; Copley R; Bork P
DDT - a novel domain in different transcription and chromosome remodeling factors
Trends in Biochemical Sciences 26: 145-146 (2001-01-01)
Huynen MA; Snel B; Bork P; Gibson TJ
The phylogenetic distribution of frataxin indicates a role in iron-sulfur cluster protein assembly
Human Molecular Genetics 10: 2463-2468 (2001-01-01)
Huynen MA; Snel B; Bork P
Inversions and the dynamics of eukaryotic gene order
Trends in Genetics 17: 304-306 (2001-06-01)
Perez-Iratxeta C; Bork P; Andrade MA
XplorMed: a tool for exploring MEDLINE abstracts
Trends in Biochemical Sciences 26: 573-575 (2001-01-01)
Ettema T; van der Oost J; Huynen M
Modularity in the gain and loss of genes: applications for function prediction
Trends in Genetics 17 (9): 485-487 (2001-09)
Sunyaev SR; Ramensky V; Koch I; Lathe W; Kondrashov AS; Bork P
Prediction of deleterious human alleles
Human Molecular Genetics 10: 591-597 (2001-01-01)
Bork P; Copley R
The draft sequences. Filling in the gaps
Nature 409: 818-820 (2001-01-01)
Lander ES; Linton LM; Birren B; Nusbaum C; Zody MC; Baldwin J; Devon K; Dewar K; Doyle M; FitzHugh W; Funke R; Gage D; Harris K; Heaford A; Howland J; Kann L; Lehoczky J; LeVine R; McEwan P; McKernan K; Meldrim J; Mesirov JP; Miranda C; Morris W; Naylor J; Raymond C; Rosetti M; Santos R; Sheridan A; Sougnez C; Stange-Thomann N; Stojanovic N; Subramanian A; Wyman D; Rogers J; Sulston J; Ainscough R; Beck S; Bentley D; Burton J; Clee C; Carter N; Coulson A; Deadman R; Deloukas P; Dunham A; Dunham I; Durbin R; French L; Grafham D; Gregory S; Hubbard T; Humphray S; Hunt A; Jones M; Lloyd C; McMurray A; Matthews L; Mercer S; Milne S; Mullikin JC; Mungall A; Plumb R; Ross M; Shownkeen R; Sims S; Waterston RH; Wilson RK; Hillier LW; McPherson JD; Marra MA; Mardis ER; Fulton LA; Chinwalla AT; Pepin KH; Gish WR; Chissoe SL; Wendl MC; Delehaunty KD; Miner TL; Delehaunty A; Kramer JB; Cook LL; Fulton RS; Johnson DL; Minx PJ; Clifton SW; Hawkins T; Branscomb E; Predki P; Richardson P; Wenning S; Slezak T; Doggett N; Cheng JF; Olsen A; Lucas S; Elkin C; Uberbacher E; Frazier M; Gibbs RA; Muzny DM; Scherer SE; Bouck JB; Sodergren EJ; Worley KC; Rives CM; Gorrell JH; Metzker ML; Naylor SL; Kucherlapati RS; Nelson DL; Weinstock GM; Sakaki Y; Fujiyama A; Hattori M; Yada T; Toyoda A; Itoh T; Kawagoe C; Watanabe H; Totoki Y; Taylor T; Weissenbach J; Heilig R; Saurin W; Artiguenave F; Brottier P; Bruls T; Pelletier E; Robert C; Wincker P; Rosenthal A; Platzer M; Nyakatura G; Taudien S; Rump A; Yang HM; Yu J; Wang J; Huang GY; Gu J; Hood L; Rowen L; Madan A; Qin SZ; Davis RW; Federspiel NA; Abola AP; Proctor MJ; Myers RM; Schmutz J; Dickson M; Grimwood J; Cox DR; Olson MV
Initial sequencing and analysis of the human genome
Nature 409 (6822): 860-921 (2001-02-15)
Sunyaev SR; Lathe W; Bork P
Integration of genome data and protein structures: prediction of protein folds, protein interactions and 'molecular phenotypes' of single nucleotide polymorphisms
Current Opinion in Structural Biology 11: 125-130 (2001-01-01)
Wang R; Zheng L; Toure YT; Dandekar T; Kafatos FC
When genetic distance matters: measuring genetic differentiation at microsatellite loci in whole-genome scans of recent and incipient mosquito species
Proceedings of the National Academy of Sciences of the United States of America 98 (19): 10769-10774 (2001-09-11)
2000
Sunyaev SR; Lathe WC; Ramensky VE; Bork P
SNP frequencies in human genes - an excess of rare alleles and differing modes of selection
Trends in Genetics 16: 335-337 (2000-08-01)
Schultz J; Doerks T; Ponting CP; Copley RR; Bork P
More than 1,000 putative new human signalling proteins revealed by EST data mining
Nature Genetics 25: 201-204 (2000-06-01)
Stoeber G; Saar K; Rueschendorf F; Meyer J; Nuernberg G; Jatzke S; Franzek E; Reis A; Lesch KP; Wienker TF; Beckmann H
Splitting schizophrenia: Periodic catatonia-susceptibility locus on chromosome 15q15
American Journal of Human Genetics 67: 1201-1207 (2000-11-01)
Schuster S; Fell DA; Dandekar T
A general definition of metabolic pathways useful for systematic organization and analysis of complex metabolic networks
Nature Biotechnology 18 (3): 326-332 (2000-03-01)
Sunyaev SR; Ramensky V; Bork P
Towards a structural basis of human non-synonymous single nucleotide polymorphisms
Trends in Genetics 16: 198-200 (2000-05-01)
Snel B; Bork P; Huynen M
Genome evolution - gene fusion versus gene fission
Trends in Genetics 16: 9-11 (2000-01-01)
Brett D; Lehmann G; Hanke J; Gross S; Reich J; Bork P
EST analysis online: WWW tools for detection of SNPs and alternative splice forms
Trends in Genetics 16: 416-418 (2000-09-01)
Eisenhaber B; Bork P; Yuan YP; Loeffler G; Eisenhaber F
Automated annotation of GPI anchor sites: case study C-elegans
Trends in Biochemical Sciences 25: 340-341 (2000-07-01)
Bork P; Eisenberg D
Sequences and topology. Genome and proteome informatics - Editorial overview
Current Opinion in Structural Biology 10: 341-342 (2000-06-01)
Hoersch S; Leroy C; Brown NP; Andrade MA; Sander C
The GeneQuiz web server: protein functional analysis through the Web
Trends in Biochemical Sciences 25: 33-35 (2000-01-01)
Knoblauch H; Mueller-Myhsok B; Busjahn A; Avi LB; Baehring S; Baron H; Heath SC; Uhlmann R; Faulhaber HD; Shpitzen S; Aydin A; Reshef A; Rosenthal M; Eliav O; Muhl A; Lowe A; Schurr D; Harats D; Jeschke E; Friedlander Y; Schuster H; Luft FC; Leitersdorf E
A cholesterol-lowering gene maps to chromosome 13q
American Journal of Human Genetics 66: 157-166 (2000-01-01)
Lathe WC; Snel B; Bork P
Gene context conservation of a higher order than operons
Trends in Biochemical Sciences 25: 474-479 (2000-10-01)
Doerks T; Strauss M; Brendel M; Bork P
GRAM, a novel domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins
Trends in Biochemical Sciences 25: 483-485 (2000-10-01)
Huynen MA; Snel B; Lathe W; Bork P
Exploitation of gene context
Current Opinion in Structural Biology 10: 366-370 (2000-06-01)
Lee YA; Rueschendorf F; Windemuth C; Schmitt-Egenolf M; Stadelmann A; Nuernberg G; Staender M; Wienker TF; Reis A; Traupe H
Genomewide scan in German families reveals evidence for a novel psoriasis-susceptibility locus on chromosome 19p13
American Journal of Human Genetics 67 (4): 1020-1024 (2000-10-01)
Doerks T; Bork P; Kamberov E; Makarova O; Muecke S; Margolis B
L27, a novel heterodimerization domain in receptor targeting proteins Lin-2 and Lin-7
Trends in Biochemical Sciences 25: 317-318 (2000-07-01)
1999
van Nimwegen E; Crutchfield JP; Huynen M
Neutral evolution of mutational robustness
Proceedings of the National Academy of Sciences of the United States of America 96: 9716-9720 (1999-08-17)
Reich J
View from the east
Science 286: 1087-1087 (1999-11-05)
Ponting CP; Hofmann K; Bork P
A latrophilin/CL-1-like GPS domain in polycystin-1
Current Biology 9: R585-R588 (1999-08-26)
Morett E; Bork P
A novel transactivation domain in parkin
Trends in Biochemical Sciences 24: 229-231 (1999-06-01)
Bork P; Doerks T; Springer TA; Snel B
Domains in plexins: links to integrins and transcription factors
Trends in Biochemical Sciences 24: 261-263 (1999-07-01)
Hanke J; Brett D; Zastrow I; Aydin A; Delbrueck S; Lehmann G; Luft FC; Reich J; Bork P
Alternative splicing of human genes - more the rule than the exception?
Trends in Genetics 15: 389-390 (1999-10-01)
Huynen MA; Snel B; Bork P
Lateral gene transfer, genome surveys, and the phylogeny of prokaryotes
Science 286: 1443a-1443 (1999-01-01)
Snel B; Bork P; Huynen MA
Genome phylogeny based on gene content
Nature Genetics 21: 108-110 (1999-01-01)
Nagle DL; McGrail SH; Vitale J; Wolf EA; Dussault BJ; DiRocco L; Holmgren L; Montagno J; Bork P; Huszar D; Fairchild-Huntress V; Ge P; Keilty J; Ebeling C; Baldini L; Gilchrist J; Burn P; Carlson GA; Moore KJ
The mahogany protein is a receptor involved in suppression of obesity
Nature 398: 148-152 (1999-03-11)
1998
Zheng ZM; Huynen M; Baker CC
A pyrimidine-rich exonic splicing suppressor binds multiple RNA splicing factors and inhibits spliceosome assembly
Proceedings of the National Academy of Sciences of the United States of America 95 (24): 14088-14093 (1998-11-24)
Huynen MA; Bork P
Measuring genome evolution
Proceedings of the National Academy of Sciences of the United States of America 95 (11): 5849-5856 (1998-05-26)
Dandekar T; Snel B; Huynen M; Bork P
Conservation of gene order: a fingerprint of proteins that physically interact
Trends in Biochemical Sciences 23 (9): 324-328 (1998-09-01)
Petfalski E; Dandekar T; Henry Y; Tollervey D
Processing of the precursors to small nucleolar RNAs and rRNAs requires common components
Molecular and Cellular Biology 18 (3): 1181-1189 (1998-03)
Schultz J; Milpetz F; Bork P; Ponting CP
SMART, a simple modular architecture research tool: Identification of signaling domains
Proceedings of the National Academy of Sciences of the United States of America 95 (11): 5857-5864 (1998-05-26)
Doerks T; Bairoch A; Bork P
Protein annotation: detective work for function prediction
Trends in Genetics 14: 248-250 (1998-01-01)
Varon R; Vissinga C; Platzer M; Cerosaletti KM; Chrzanowska KH; Saar K; Beckmann G; Seemanova E; Cooper PR; Nowak NJ; Stumm M; Weemaes CMR; Gatti RA; Wilson RK; Digweed M; Rosenthal A; Sperling K; Concannon P; Reis A
Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome
Cell 93 (3): 467-476 (1998-05-01)
Eisenhaber F; Bork P
Wanted: subcellular localization of proteins based on sequence
Trends in Cell Biology 8: 169-170 (1998-01-01)
Eisenhaber F
Stops genejockeys being taken for a ride
Trends in Cell Biology 8 (9): 377-378 (1998-09-01)
Bork P; Koonin EV
Predicting functions from protein sequences - where are the bottlenecks?
Nature Genetics 18: 313-318 (1998-01-01)
1997
Henikoff S; Greene EA; Pietrokovski S; Bork P; Attwood TK; Hood L
Gene families: the taxonomy of protein paralogs and chimeras
Science 278 (5338): 609-614 (1997-10-24)
Ponting C; Schultz J; Bork P
SPRY domains in ryanodine receptors (Ca2+ release channels)
Trends in Biochemical Sciences 22: 193-194 (1997-01-01)
Huynen MA; Diaz-Lazcoz Y; Bork P
Differential genome display
Trends in Genetics 13: 389-390 (1997-01-01)
Yuan YP; Schultz J; Mlodzik M; Bork P
Secreted fringe like signaling molecules may be glycosyltransferases
Cell 88: 9-11 (1997-01-01)
Saar K; Chrzanowska KH; Stumm M; Jung M; Nuernberg G; Wienker TF; Seemanova E; Wegner RD; Reis A; Sperling K
The gene for the ataxia telangiectasia variant, nijmegen breakage syndrome, maps to a 1 cm interval on chromosome 8q21
American Journal of Human Genetics 60 (3): 605-610 (1997-03)
Bork P; Hofmann K; Bucher P; Neuwald A; Altschul SF; Koonin EV
A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins
FASEB Journal 11 (1): 68-76 (1997-01-01)
Mushegian AR; Bassett DE; Boguski MS; Bork P; Koonin EV
Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs
Proceedings of the National Academy of Sciences of the United States of America 94: 5831-5836 (1997-01-01)
Rohde K; Teare MD; Koref MS
Analysis of genetic linkage and somatic loss of heterozygosity in affected pairs of first-degree relatives
American Journal of Human Genetics 61: 418-422 (1997-01-01)
Starfield M; Hennies HC; Jung M; Jenkins T; Wienker TF; Hull P; Spurdle A; Kuester W; Ramsay M; Reis A
Localization of the gene causing keratolytic winter erythema to chromosome 8p22-p23, and evidence for a founder effect in south african afrikaans-speakers
American Journal of Human Genetics 61 (2): 370-378 (1997-08)
Greene EA; Pietrokovski S; Henikoff S; Bork P; Attwood TK; Hood L; Bairoch A
Genome maps 8. Building gene families. Wall chart
Science 278: 615-626 (1997-01-01)
Goerlich D; Dabrowski M; Bischoff FR; Kutay U; Bork P; Hartmann E; Prehn S; Izaurralde E
A novel class of RanGTP binding proteins
Journal of Cell Biology 138 (1): 65-80 (1997-07-14)
Robinson RI; Monnier N; Wolz W; Jung M; Reis A; Nuernberg G; Curran JL; Monsieurs K; Stieglitz P; Heytens L; Fricker R; Vanbroeckhoven C; Deufel T; Hopkins PM; Lunardi J; Mueller CR
A genome wide search for susceptibility loci in three european malignant hyperthermia pedigrees
Human Molecular Genetics 6 (6): 953-961 (1997-06)
Bork P; Schultz J; Ponting CP
Cytoplasmic signalling domains: the next generation
Trends in Biochemical Sciences 22: 296-298 (1997-01-01)
Morozov V; Mushegian AR; Koonin EV; Bork P
A putative nucleic acid-binding domain in Werner's and Bloom's syndrome helicases
Trends in Biochemical Sciences 22: 417-418 (1997-01-01)
Baehring S; Nagai T; Toka HR; Nitz I; Toka O; Aydin A; Muhl A; Wienker TF; Schuster H; Luft FC
Deletion at 12p in a japanese child with brachydactyly overlaps the assigned locus of brachydactyly with hypertension in a turkish family
American Journal of Human Genetics 60: 732-735 (1997-01-01)
1996
Koonin EV; Altschul SF; Bork P
BRCA1 protein products ... Functional motifs...
Nature Genetics 13 (3): 266-268 (1996-07-01)
Bork P
Sperm-egg binding protein or proto-oncogene?
Science 271 (5254): 1431-1432 (1996-01-01)
Gibson T; Koonin EV; Musco G; Pastore A; Bork P
Friedreich's atataxia protein: phylogenetic evidence for mitochondrial disfunction
Trends in Neurosciences 19: 465-468 (1996-01-01)
Koonin EV; Mushegian AR; Bork P
Non-orthologous gene displacement
Trends in Genetics 12: 334-336 (1996-01-01)
Koonin EV; Bork P
Ancient duplication of dna polymerase inferred from analysis of complete bacterial genomes
Trends in Biochemical Sciences 21 (4): 128-129 (1996-01-01)
Bork P; Bairoch A
Go huntig in sequence databases but watch out for the traps
Trends in Genetics 12: 425-427 (1996-01-01)
Bork P; Blomberg N; Nilges M
Internal repeats in the BRCA2 protein sequence
Nature Genetics 13: 22-23 (1996-01-01)
Nagle DL; Karim M; Woolf EA; Holmgren L; Bork P; Misumi D; McGrail D; Dussault JR; Duyk G; Spritz RA; Moore KJ
Identification and mutation analysis of the complete gene for the Chediak-Higashi syndrome
Nature Genetics 14: 307-312 (1996-01-01)
Bork P; Downing AK; Kieffer B; Campbell ID
Structure and distribution of modules in extracellular proteins
Quaterly Reviews of Biophysics 29 (2): 119-167 (1996-05-01)
Ponting CP; Bork P
Pleckstrin's repeat performance: a novel domain in g protein signaling
Trends in Biochemical Sciences 21: 245-246 (1996-01-01)
Schuster H; Wienker TF; Baehring S; Bilginturan N; Toka HR; Neitzel H; Jeschke E; Toka O; Gilbert D; Lowe A; Ott J; Haller H; Luft FC
Severe autosomal dominant hypertension and brachydactyly in a unique turkish kindred maps to human chromosome 12
Nature Genetics 13 (1): 98-100 (1996-01-01)
1995
Gluecksmann-Kuis MA; Tayber O; Woolf EA; Bougueleret L; Deng NH; Alperin GD; Iris F; Hawkins F; Munro C; Lakey N; Duyk G; Schneider MC; Geng L; Zhang F; Zhao ZH; Torosian S; Zhou J; Reeders ST; Bork P; Pohlschmidt M; Lohning C; Kraus B; Nowicka U; Leung ALS; Frischauf AM
Polycystic kidney disease: the complete structure of the PKD1 gene and its protein
Cell 81 (2): 289-298 (1995-04-21)
Bork P; Margolis B
A phosphotyrosine interaction domain
Cell 80 (5): 693-694 (1995-01-01)
Casari G; Andrade MA; Bork P; Daruvar A; Ouzounis C; Schneider R; Tamames J; Valencia A; Sander C
Challenging times for bioinformatics
Nature 376: 647-648 (1995-01-01)
Andrade MA; Bork P
Heat repeats in Huntington's disease protein
Nature Genetics 11 (2): 115-116 (1995-10-01)
1994
Thein SL; Sampietro M; Rohde K; Rochette J; Weatherall DJ; Lathrop GM; Demenais F
Detection of a major gene for heterocellular hereditary persistence of fetal hemoglobin after accounting for genetic modifiers
American Journal of Human Genetics 54 (2): 214-228 (1994-02)
Bork P; Sudol M
The WW domain: a signalling site in dystrophin
Trends in Biochemical Sciences 19 (12): 531-533 (1994-12-01)
Koonin E; Bork P; Sander C
Yeast chromosome III: new gene functions
EMBO Journal 13: 493-503 (1994-01-01)
1993
Beckmann G; Bork P
An adhesive domain detected in functionally diverse receptors
Trends in Biochemical Sciences 18: 40-41 (1993-01-01)
Meitinger T; Meindl A; Bork P; Rost B; Sander C; Haasemann M; Murken J
Molecular modelling of the norrie disease protein predicts a cystine knot growth factor tertiary structure
Nature Genetics 5: 376-380 (1993-01-01)
Zimmermann W; Bender E; Rohde K; Reis A; Wiseman R; Futreal A; Krause H; Prokoph H; Werner S; Scherneck S
Linkage analysis in German breast cancer families with early onset of the disease, using highly polymorphic markers from the chromosome 17q11-q24 region
American Journal of Human Genetics 52 (4): 789-791 (1993-04)
1992
Bork P; Doolittle RF
Proposed acquisition of an animal protein domain by bacteria
Proceedings of the National Academy of Sciences of the United States of America 89: 8990-8994 (1992-01-01)