Publikationen
2012
Courtial N; Smink JJ; Kuvardina ON; Leutz A; Goethert JR; Lausen J
Tal1 regulates osteoclast differentiation through suppression of the master regulator of cell fusion DC-STAMP
FASEB Journal 26 (2): 523-532 (2012-02)
Smink JJ; Tunn PU; Leutz A
Rapamycin inhibits osteoclast formation in giant cell tumor of bone through the C/EBP{beta} - MafB axis
Journal of Molecular Medicine 90 (1): 25-30 (2012-01)
2011
Pless O; Kowenz-Leutz E; Dittmar G; Leutz A
A differential proteome screening system for post-translational modification-dependent transcription factor interactions
Nature Protocols 6 (3): 359-364 (2011-02)
Mielke N; Schwarzer R; Calkhoven CF; Kaufman R; Doerken B; Leutz A; Jundt F
Eukaryotic initiation factor 2{alpha} phosphorylation is required for B cell maturation and function in mice
Haematologica 96 (9): 1261-1268 (2011-09)
Thomae AW; Baltin J; Pich D; Deutsch MJ; Ravasz M; Zeller K; Gossen M; Hammerschmidt W; Schepers A
Different roles of the human Orc6 protein in the replication initiation process
Cellular and Molecular Life Sciences 68 (22): 3741-3756 (2011-11)
2010
Kowenz-Leutz E; Pless O; Dittmar G; Knoblich M; Leutz A
Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code
EMBO Journal 29 (6): 1105-1115 (2010-03-17)
Zaragoza K; Begay V; Schuetz A; Heinemann U; Leutz A
Repression of transcriptional activity of C/EBP{alpha} by E2F-DP complexes
Molecular and Cellular Biology 30 (9): 2293-2304 (2010-05)
Wethmar K; Begay V; Smink JJ; Zaragoza K; Wiesenthal V; Doerken B; Calkhoven CF; Leutz A
C/EBPbetaDeltauORF mice--a genetic model for uORF-mediated translational control in mammals
Genes & Development 24 (1): 15-20 (2010-01-01)
Smink JJ; Leutz A
Rapamycin and the transcription factor C/EBPbeta as a switch in osteoclast differentiation: implications for lytic bone diseases
Journal of Molecular Medicine 88 (3): 227-233 (2010-03)
Orinska Z; Foeger N; Huber M; Marschall J; Mirghomizadeh F; Du X; Scheller M; Rosenstiel P; Goldmann T; Bollinger A; Beutler BA; Bulfone-Paus S
I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development
Blood 116 (15): 2665-2675 (2010-10-14)
Lausen J; Pless O; Leonard F; Kuvardina-Bolling ON; Koch B; Leutz A
Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1
Journal of Biological Chemistry 285 (8): 5338-5346 (2010-02-19)
2009
Broeske AM; Vockentanz L; Kharazi S; Huska MR; Mancini E; Scheller M; Kuhl C; Enns A; Prinz M; Jaenisch R; Nerlov C; Leutz A; Andrade-Navarro MA; Jacobsen SE; Rosenbauer F
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction
Nature Genetics 41 (11): 1207-1215 (2009-11)
Smink JJ; Begay V; Schoenmaker T; Sterneck E; de Vries TJ; Leutz A
Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB
EMBO Journal 28 (12): 1769-1781 (2009-06-17)
2008
Pless O; Kowenz-Leutz E; Knoblich M; Lausen J; Beyerman M; Walsh MJ; Leutz A
G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta
Journal of Biological Chemistry 283 (39): 26357-26363 (2008-09-26)
Simmons DG; Natale DR; Begay V; Hughes M; Leutz A; Cross JC
Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth
Development 135 (12): 2083-2091 (2008-06)
Jeannet G; Scheller M; Scarpellino L; Duboux S; Gardiol N; Back J; Kuttler F; Malanchi I; Birchmeier W; Leutz A; Huelsken J; Held W
Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin
Blood 111 (1): 142-149 (2008-01-01)
2006
Wiesenthal V; Leutz A; Calkhoven CF
Analysis of translation initiation using a translation control reporter system
Nature Protocols 1 (3): 1531-1537 (2006-11-09)
Wiesenthal V; Leutz A; Calkhoven CF
A translation control reporter system (TCRS) for the analysis of translationally controlled processes in the vertebrate cell
Nucleic Acids Research 34 (3): e23 (2006-02-10)
Rosenbauer F; Owens BM; Yu L; Tumang JR; Steidl U; Kutok JL; Clayton LK; Wagner K; Scheller M; Iwasaki H; Liu C; Hackanson B; Akashi K; Leutz A; Rothstein TL; Plass C; Tenen DG
Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1
Nature Genetics 38 (1): 27-37 (2006-01)
Scheller M; Huelsken J; Rosenbauer F; Taketo MM; Birchmeier W; Tenen DG; Leutz A
Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation
Nature Immunology 7 (10): 1037-1047 (2006-10)
Lausen J; Liu S; Fliegauf M; Luebbert M; Werner MH
ELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO
Oncogene 25: 1349-1357 (2006-03-02)
2005
Jundt F; Raetzel N; Mueller C; Calkhoven CF; Kley K; Mathas S; Lietz A; Leutz A; Doerken B
A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein beta and NF-kappaB activity in Hodgkin and anaplastic large cell lymphomas
Blood 106: 1801-1807 (2005-01-01)
Lucas B; Grigo K; Erdmann S; Lausen J; Klein-Hitpass L; Ryffel GU
HNF4alpha reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma
Oncogene 24: 6418-6431 (2005-09-22)
Mo X; Kowenz-Leutz E; Laumonnier Y; Xu H; Leutz A
Histone H3 tail positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domain
Genes & Development 19: 2447-2457 (2005-09-29)
2004
Begay V; Smink J; Leutz A
Essential requirement of CCAAT/enhancer binding proteins in embryogenesis
Molecular and Cellular Biology 24: 9744-9751 (2004-11-01)
Bourbon HM; Aguilera A; Ansari AZ; Asturias FJ; Berk AJ; Bjorklund S; Blackwell TK; Borggrefe T; Carey M; Carlson M; Conaway JW; Conaway RC; Emmons SW; Fondell JD; Freedman LP; Fukasawa T; Gustafsson CM; Han M; He X; Herman PK; Hinnebusch AG; Holmberg S; Holstege FC; Jaehning JA; Kim YJ; Kuras L; Leutz A; Lis JT; Meisterernest M; Naar AM; Nasmyth K; Parvin JD; Ptashne M; Reinberg D; Ronne H; Sadowski I; Sakurai H; Sipiczki M; Sternberg PW; Stillman DJ; Strich R; Struhl K; Svejstrup JQ; Tuck S; Winston F; Roeder RG; Kornberg RD
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II
Molecular Cell 14: 553-557 (2004-01-01)
Hu WH; Mo XM; Walters WM; Brambilla R; Bethea JR
TNAP, a novel repressor of NF-kappaB-inducing kinase, suppresses NF-kappaB activation
Journal of Biological Chemistry 279: 35975-35983 (2004-01-01)
Mueller C; Calkhoven CF; Sha XJ; Leutz A
The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest
Journal of Biological Chemistry 279: 7353-7358 (2004-01-01)
Mo XM; Kowenz-Leutz E; Xu H; Leutz A
Ras induces mediator complex exchange on C/EBPbeta
Molecular Cell 13: 241-250 (2004-01-01)
2003
Andersson KB; Kowenz-Leutz E; Brendeford EM; Tygsett AHH; Leutz A; Gabrielsen OS
Phosphorylation-dependent down-regulation of c-Myb DNA binding is abrogated by a point mutation in the v-myb oncogene
Journal of Biological Chemistry 278: 3816-3824 (2003-01-01)
Calkhoven CF; Mueller C; Martin R; Krosl G; Hoang T; Leutz A
Translational control of SCL-isoform expression in hematopoietic lineage choice
Genes & Development 17 (8): 959-964 (2003-01-01)
Rushton JJ; Davis LM; Lei WL; Mo XM; Leutz A; Ness SA
Distinct changes in gene expression induced by A-Myb, B-Myb and c-Myb proteins
Oncogene 22: 308-313 (2003-01-01)
2002
Calkhoven CF; Mueller C; Leutz A
Translational control of gene expression and disease
Trends in Molecular Medicine 8: 577-583 (2002-01-01)
Ansieau S; Leutz A
The conserved Mynd domain of BS69 binds cellular and oncoviral proteins through a common PXLXP motif
Journal of Biological Chemistry 277: 4906-4910 (2002-01-01)
2001
Pedersen TA; Kowenz-Leutz E; Leutz A; Nerlov C
Cooperation between C/EBP alphaTBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation
Genes & Development 15: 3208-3216 (2001-01-01)
Oelgeschlager M; Kowenz-Leutz E; Schreek S; Leutz A; Luescher B
Tumorigenic N-terminal deletions of c-Myb modulate DNA binding, transactivation, and cooperativity with C/EBP
Oncogene 20: 7420-7424 (2001-01-01)
Mueller C; Leutz A
Chromatin remodeling in development and differentiation
Current Opinion in Genetics & Development 11: 167-174 (2001-01-01)
Ansieau S; Strobl LJ; Leutz A
Activation of the Notch-regulated transcription factor CBF1/RBP-J kappa through the 13SE1A oncoprotein
Genes & Development 15: 380-385 (2001-01-01)
2000
Calkhoven CF; Mueller C; Leutz A
Translational control of C/EBP alpha and C/EBP beta isoform expression
Genes & Development 14: 1920-1932 (2000-08-01)
1999
Mueller C; Alunni-Fabroni M; Kowenz-Leutz E; Mo XM; Tommasino M
Separation of C/EBP alpha-mediated proliferation arrest and differentiation pathways
Proceedings of the National Academy of Sciences of the United States of America 96: 7276-7281 (1999-06-22)
Kowenz-Leutz E; Leutz A
A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes
Molecular Cell 4: 735-743 (1999-11-01)
Dechend R; Hirano F; Lehmann K; Heissmeyer V; Ansieau S; Wulczyn FG; Scheidereit C; Leutz A
The Bcl-3 oncoprotein acts as a bridging factor between NF-kappa B/Rel and nuclear co-regulators
Oncogene 18: 3316-3323 (1999-06-03)
Dechend R; Maass M; Gieffers J; Dietz R; Scheidereit C; Leutz A; Gulba DC
Chlamydia pneumoniae infection of vascular smooth muscle and endothelial cells activates NF-kappaB and induces tissue factor and PAI-1 expression - A potential link to accelerated arteriosclerosis
Circulation 100: 1369-1373 (1999-09-28)
1998
Nerlov C; McNagny KM; Doederlein G; Kowenz-Leutz E; Graf T
Distinct C/EBP functions are required for eosinophil lineage commitment and maturation
Genes & Development 12 (15): 2413-2423 (1998-08-01)
1997
Dhordain P; Albagli O; Lin RJ; Ansieau S; Quief S; Leutz A; Kerckaert J-P; Evans RM; Leprince D
Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein
Proceedings of the National Academy of Sciences of the United States of America 94 (20): 10762-10767 (1997-09-30)
Kowenz-Leutz E; Herr P; Niss K; Leutz A
The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation
Cell 91: 185-195 (1997-01-01)
1996
Twamley-Stein G; Kowenz-Leutz E; Ansieau S; Leutz A
Regulation of C/EBPbeta /NF-M activity by kinase oncogenes
Current Topics in Microbiology and Immunology 211: 129-136 (1996-01-01)
1995
Dhordain P; Albagli O; Ansieau S; Koken M; Deweindt C; Quief S; Lantoine D; Leutz A; Kerckaert J-P; Leprince D
The BTB/POZ domain targets the LAZ3/BCL6 oncoprotein to nuclear dots and mediates homodimerization in vitro
Oncogene 11 (12): 2689-2697 (1995-12-21)
Mueller C; Kowenz-Leutz E; Grieser-Ade S; Graf T; Leutz A
NF-M (C/EBPbeta) induces eosinophilic differentiation and apoptosis in a hematopoietic progenitor cell line
EMBO Journal 14 (24): 6127-6135 (1995-01-01)
1994
Kowenz-Leutz E; Twamley G; Ansieau S; Leutz A
Novel mechanism of C/EBPbeta (NF-M) transcriptional control: activation through derepression
Genes & Development 8 (22): 2781-2791 (1994-11-15)
Pope RM; Leutz A; Ness SA
C/EBP beta regulation of the tumor necrosis factor alpha gene
Journal of Clinical Investigation 94 (4): 1449-1455 (1994-10)
1993
Katz S; Kowenz-Leutz E; Mueller C; Meese K; Ness SA; Leutz A
The NF-M transcription factor is related to C/EBP beta and plays a role in signal transduction, differentiation and leukemogenesis of avian myelomonocytic cells
EMBO Journal 12 (4): 1321-1332 (1993-04)
Ness SA; Kowenz-Leutz E; Casini T; Graf T; Leutz A
Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types
Genes & Development 7 (5): 749-759 (1993-05)
1992
Sterneck E; Mueller C; Katz S; Leutz A
Autocrine growth induced by kinase type oncogenes in myeloid cells requires AP-1 and NF-M, a myeloid specific, C/EBP-like factor
EMBO Journal 11 (1): 115-126 (1992-01)
Haas JG; Stroebel M; Leutz A; Wendelgass P; Mueller C; Sterneck E; Riethmueller G; Ziegler Heitbrock HW
Constitutive monocyte-restricted activity of NF-M, a nuclear factor that binds to a C/EBP motif
Journal of Immunology 149 (1): 237-243 (1992-07-01)
Sterneck E; Blattner C; Graf T; Leutz A
Structure of the chicken myelomonocytic growth factor gene and specific activation of its promoter in avian myelomonocytic cells by protein kinases
Molecular and Cellular Biology 12 (4): 1728-1735 (1992-04)