Hier finden Sie Publikationen unserer Mitarbeiter.
2012
Keil M; Siegert A; Eckert K; Gerlach J; Haider W; Fichtner I
Transcriptional expression profile of cultured human embryonic stem cells in vitro and in vivo
In Vitro Cellular & Developmental Biology Animal 48 (3): 165-174 (2012-03)
Sokolenko AP; Iyevleva AG; Preobrazhenskaya EV; Mitiushkina NV; Abysheva SN; Suspitsin EN; Kuligina ES; Gorodnova TV; Pfeifer W; Togo AV; Turkevich EA; Ivantsov AO; Voskresenskiy DV; Dolmatov GD; Bit-Sava EM; Matsko DE; Semiglazov VF; Fichtner I; Larionov AA; Kuznetsov SG; Antoniou AC; Imyanitov EN
High prevalence and breast cancer predisposing role of the BLMc.1642 C>T (Q548X) mutation in Russia
International Journal of Cancer 130 (12): 2867-2873 (2012-06-15)
Wulf-Goldenberg A; Keil M; Fichtner I; Eckert K
Intrahepatic transplantation of CD34(+) cord blood stem cells into newborn and adult NOD/SCID mice induce differential organ engraftment
Tissue & Cell 44 (2): 80-86 (2012-04)
Orthmann A; Zeisig R; Suess R; Lorenz D; Lemm M; Fichtner I
Treatment of experimental brain metastasis with MTO-liposomes: impact of fluidity and LRP-targeting on the therapeutic result
Pharmaceutical Research : (2012-03-08)
2011
Orthmann A; Fichtner I; Zeisig R
Improving the transport of chemotherapeutic drugs across the blood-brain barrier
Expert Review of Clinical Pharmacology 4 (4): 477-490 (2011-07)
Sack U; Walther W; Scudiero D; Selby M; Aumann J; Lemos C; Fichtner I; Schlag PM; Shoemaker RH; Stein U
S100A4-induced cell motility and metastasis is restricted by the Wnt/{beta}-catenin pathway inhibitor calcimycin in colon cancer cells
Molecular Biology of the Cell 22 (18): 3344-3354 (2011-09)
Winsel S; Sommer A; Eschenbrenner J; Mittelstaedt K; Klar U; Hammer S; Hoffmann J
Molecular mode of action and role of TP53 in the sensitivity to the novel epothilone sagopilone (ZK-EPO) in A549 non-small cell lung cancer cells
PLoS ONE 6 (4): e19273 (2011-04-29)
Walther W; Petkov S; Kuvardina ON; Aumann J; Kobelt D; Fichtner I; Lemm M; Piontek J; Blasig IE; Stein U; Schlag PM
Novel Clostridium perfringens enterotoxin suicide gene therapy for selective treatment of claudin-3- and -4-overexpressing tumors
Gene Therapy : (2011-10-06)
Calderon M; Welker P; Licha K; Fichtner I; Graeser R; Haag R; Kratz F
Development of efficient acid cleavable multifunctional prodrugs derived from dendritic polyglycerol with a poly (ethylene glycol) shell
Journal of Controlled Release 151 (3): 295-301 (2011-05-10)
Merk J; Rolff J; Dorn C; Leschber G; Fichtner I
Chemoresistance in non-small-cell lung cancer: can multidrug resistance markers predict the response of xenograft lung cancer models to chemotherapy?
European Journal of Cardio-Thoracic Surgery 40 (1): e29-e33 (2011-07)
Abu Ajaj K; El-Abadla N; Welker P; Azab S; Zeisig R; Fichtner I; Kratz F
Comparative evaluation of the biological properties of reducible and acid-sensitive folate prodrugs of a highly potent doxorubicin derivative
European Journal of Cancer : (2011-09-19)
Fichtner I; Behrens D; Claffey J; Deally A; Gleeson B; Patil S; Weber H; Tacke M
The antiangiogenic and antitumoral activity of titanocene Y* in vivo
Letters in Drug Design & Discovery 8 (4): 302-307 (2011-05)
Sack U; Walther W; Scudiero D; Selby M; Kobelt D; Lemm M; Fichtner I; Schlag PM; Shoemaker RH; Stein U
Novel effect of antihelminthic niclosamide on S100A4-mediated metastatic progression in colon cancer
Journal of the National Cancer Institute 103 (13): 1018-1036 (2011-07-06)
Kratz F; Fichtner I; Graeser R
Combination therapy with the albumin-binding prodrug of doxorubicin (INNO-206) and doxorubicin achieves complete remissions and improves tolerability in an ovarian A2780 xenograft model
Investigational New Drugs : (2011-05-18)
Bijnsdorp IV; Schwendener RA; Schott H; Fichtner I; Smid K; Laan AC; Schott S; Losekoot N; Honeywell RJ; Peters GJ
Cellular pharmacology of multi- and duplex drugs consisting of ethynylcytidine and 5-fluoro-2'-deoxyuridine
Investigational New Drugs 29 (2): 248-257 (2011-04)
Tan WL; Bhattacharya B; Loh M; Balasubramanian I; Akram M; Dong D; Wong L; Thakkar B; Salto-Tellez M; Soo RA; Fichtner I; Iacopetta B; Soong R
Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer
Cancer Biology & Therapy 11 (6): 599-608 (2011-03-15)
Bergman AM; Adema AD; Balzarini J; Bruheim S; Fichtner I; Noordhuis P; Fodstad O; Myhren F; Sandvold ML; Hendriks HR; Peters GJ
Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models
Investigational New Drugs 29 (3): 456-466 (2011-06)
Stein U; Arlt F; Smith J; Sack U; Herrmann P; Walther W; Lemm M; Fichtner I; Shoemaker RH; Schlag PM
Intervening in beta-catenin signaling by sulindac inhibits S100A4-dependent colon cancer metastasis
Neoplasia 13 (2): 131-144 (2011-02)
Bachmeier B; Fichtner I; Killian PH; Kronski E; Pfeffer U; Efferth T
Development of resistance towards artesunate in MDA-MB-231 human breast cancer cells
PLoS ONE 6 (5): e20550 (2011-05-26)
Wulf-Goldenberg A; Eckert K; Fichtner I
Intrahepatically transplanted human cord blood cells reduce SW480 tumor growth in the presence of bispecific EpCAM/CD3 antibody
Cytotherapy 13 (1): 108-113 (2011-01)
Abolhassani M; Guais A; Sanders E; Campion F; Fichtner I; Bonte J; Baronzio G; Fiorentini G; Israel M; Schwartz L
Screening of well-established drugs targeting cancer metabolism: reproducibility of the efficacy of a highly effective drug combination in mice
Investigational New Drugs : (2011-06-09)
2010
Brueckner B; Rius M; Rivera Markelova M; Fichtner I; Hals PA; Sandvold ML; Lyko F
Delivery of 5-azacytidine to human cancer cells by elaidic acid esterification increases therapeutic drug efficacy
Molecular Cancer Therapeutics 9 (5): 1256-1264 (2010-05)
Fichtner I; Claffey J; Deally A; Gleeson B; Hogan M; Rivera Markelova M; Mueller-Bunz H; Weber H; Tacke M
Antitumor activity of vanadocene Y and its selenocyanate derivative in xenografted CAKI-1 tumors in mice
Journal of Organometallic Chemistry 695 (8): 1175-1181 (2010-04-15)
Wenzel J; Zeisig R; Haider W; Habedank S; Fichtner I
Inhibition of pulmonary metastasis in a human MT3 breast cancer xenograft model by dual liposomes preventing intravasal fibrin clot formation
Breast Cancer Research and Treatment 121 (1): 13-22 (2010-05)
Hammer S; Sommer A; Fichtner I; Becker M; Rolff J; Merk J; Klar U; Hoffmann J
Comparative profiling of the novel epothilone, sagopilone, in xenografts derived from primary non-small cell lung cancer
Clinical Cancer Research 16 (5): 1452-1465 (2010-03-01)
Orthmann A; Zeisig R; Koklic T; Sentjurc M; Wiesner B; Lemm M; Fichtner I
Impact of membrane properties on uptake and transcytosis of colloidal nanocarriers across an epithelial cell barrier model
Journal of Pharmaceutical Sciences 99 (5): 2423-2433 (2010-05)
Wenzel J; Zeisig R; Fichtner I
Inhibition of metastasis in a murine 4T1 breast cancer model by liposomes preventing tumor cell-platelet interactions
Clinical and Experimental Metastasis 27 (1): 25-34 (2010)
Graeser R; Esser N; Unger H; Fichtner I; Zhu A; Unger C; Kratz F
INNO-206, the (6-maleimidocaproyl hydrazone derivative of doxorubicin), shows superior antitumor efficacy compared to doxorubicin in different tumor xenograft models and in an orthotopic pancreas carcinoma model
Investigational New Drugs 28 (1): 14-19 (2010-02)
Kobelt D; Aumann J; Fichtner I; Stein U; Schlag PM; Walther W
Activation of the CMV-IE promoter by hyperthermia in vitro and in vivo: biphasic heat induction of cytosine deaminase suicide gene expression
Molecular Biotechnology 46 (2): 197-205 (2010-10)
Adema AD; Laan AC; Myhren F; Fichtner I; Verheul HM; Sandvold ML; Peters GJ
Cell cycle effects of fatty acid derivatives of cytarabine, CP-4055, and of gemcitabine, CP-4126, as basis for the interaction with oxaliplatin and docetaxel
International Journal of Oncology 36 (1): 285-294 (2010-01)
Gerlach J; Luebberstedt M; Edsbagge J; Ring A; Hout M; Baun M; Rossberg I; Knoespel F; Peters G; Eckert K; Wulf-Goldenberg A; Bjoerquist P; Stachelscheid H; Urbaniak T; Schatten G; Miki T; Schmelzer E; Zeilinger K
Interwoven four-compartment capillary membrane technology for three-dimensional perfusion with decentralized mass exchange to scale up embryonic stem cell culture
Cells Tissues Organs 192 (1): 39-49 (2010-06)
Harnack U; Eckert K; Fichtner I; Pecher G
Comparison of the effect of orally administered soluble {beta}-(1-3),(1-6)-D-glucan and of G-CSF on the recovery of murine hematopoiesis
In Vivo 24 (1): 59-63 (2010-01)
Deak E; Ruester B; Keller L; Eckert K; Fichtner I; Seifried E; Henschler R
Suspension medium influences interaction of mesenchymal stromal cells with endothelium and pulmonary toxicity after transplantation in mice
Cytotherapy 12 (2): 260-264 (2010-04)
2009
Harnack U; Eckert K; Fichtner I; Pecher G
Oral administration of a soluble 1-3, 1-6 beta-glucan during prophylactic survivin peptide vaccination diminishes growth of a B cell lymphoma in mice
International Immunopharmacology 9 (11): 1298-1303 (2009-10)
Wenzel J; Zeisig R; Fichtner I
Inhibition of breast cancer metastasis by dual liposomes to disturb complex formation
International Journal of Pharmaceutics 370 (1-2): 121-128 (2009-03-31)
Yang JX; Fichtner I; Becker M; Lemm M; Wang XM
Anti-proliferative efficacy of icariin on HepG2 hepatoma and its possible mechanism of action
American Journal of Chinese Medicine 37 (6): 1153-1165 (2009)
Walther W; Fichtner I; Schlag PM; Stein US
Nonviral jet-injection technology for intratumoral in vivo gene transfer of naked DNA
Methods in Molecular Biology 542: 195-208 (2009)
Bracker TU; Sommer A; Fichtner I; Faus H; Haendler B; Hess-Stumpp H
Efficacy of MS-275, a selective inhibitor of class I histone deacetylases, in human colon cancer models
International Journal of Oncology 35 (4): 909-920 (2009-10)
Hoffmann J; Fichtner I; Lemm M; Lienau P; Hess-Stumpp H; Rotgeri A; Hofmann B; Klar U
Sagopilone crosses the blood-brain barrier in vivo to inhibit brain tumor growth and metastases
Neuro Oncology 11 (2): 158-166 (2009-04)
Merk J; Rolff J; Becker M; Leschber G; Fichtner I
Patient-derived xenografts of non-small-cell lung cancer: a pre-clinical model to evaluate adjuvant chemotherapy?
European Journal of Cardio-Thoracic Surgery 36 (3): 454-459 (2009-09)
Rolff J; Dorn C; Merk J; Fichtner I
Response of patient-derived non-small cell lung cancer xenografts to classical and targeted therapies is not related to multidrug resistance markers
Journal of Oncology 2009: 814140 (2009)
Stein U; Walther W; Arlt F; Schwabe H; Smith J; Fichtner I; Birchmeier W; Schlag PM
MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis
Nature Medicine 15 (1): 59-67 (2009-01)
Abu Ajaj K; Graeser R; Fichtner I; Kratz F
In vitro and in vivo study of an albumin-binding prodrug of doxorubicin that is cleaved by cathepsin B
Cancer Chemotherapy and Pharmacology 64 (2): 413-418 (2009-07)
Heringer-Walther S; Eckert K; Schumacher SM; Uharek L; Wulf-Goldenberg A; Gembardt F; Fichtner I; Schultheiss HP; Rodgers K; Walther T
Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo
Haematologica 94 (6): 857-860 (2009-06)
Diaz Miqueli A; Rolff J; Lemm M; Fichtner I; Perez R; Montero E
Radiosensitisation of U87MG brain tumours by anti-epidermal growth factor receptor monoclonal antibodies
British Journal of Cancer 100 (6): 950-958 (2009-03-24)
Fritzmann J; Morkel M; Besser D; Budczies J; Kosel F; Brembeck FH; Stein U; Fichtner I; Schlag PM; Birchmeier W
A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential
Gastroenterology 137 (11): 165-175 (2009-07)
2008
Fichtner I; Rolff J; Soong R; Hoffmann J; Hammer S; Sommer A; Becker M; Merk J
Establishment of patient-derived non-small cell lung cancer xenografts as models for the identification of predictive biomarkers
Clinical Cancer Research 14 (20): 6456-6468 (2008-10-15)
Ryppa C; Mann-Steinberg H; Fichtner I; Weber H; Satchi-Fainaro R; Biniossek ML; Kratz F
In vitro and in vivo evaluation of doxorubicin conjugates with the divalent peptide E-[c(RGDfK)2] that targets integrin alphavbeta3
Bioconjugate Chemistry 19 (7): 1414-1422 (2008-07)
Goldin-Lang P; Tran QV; Fichtner I; Eisenreich A; Antoniak S; Schulze K; Coupland SE; Poller W; Schultheiss HP; Rauch U
Tissue factor expression pattern in human non-small cell lung cancer tissues indicate increased blood thrombogenicity and tumor metastasis
Oncology Reports 20 (1): 123-128 (2008-07)
Bijnsdorp I; Schwendener R; Schott H; Schott S; Fichtner I; Honeywell R; Losekoot N; Laan A; Peters GJ
In vitro activity and mechanism of action of a duplex and multidrug of ethynylcytidine and 5-fluorodeoxyuridine
Nucleic Acids Symposium Series 52: 651 (2008-09-08)
Wulf-Goldenberg A; Eckert K; Fichtner I
Cytokine-pretreatment of CD34(+) cord blood stem cells in vitro reduces long-term cell engraftment in NOD/SCID mice
European Journal of Cell Biology 87 (2): 69-80 (2008-02)
Fichtner I
Praeklinische Daten als Grundlage fuer die Konzeption klinischer Studien [Preclinical data as basis for the design of clinical studies]
Onkologie 31 (Suppl. 2): 34-38 (2008-04-18)
Koklic T; Zeisig R; Sentjurc M
Interaction of alkylphospholipid liposomes with MT-3 breast-cancer cells depends critically on cholesterol concentration
Biochimica et Biophysica Acta - Biomembranes 1778 (12): 2682-2689 (2008-12)
Dowling CM; Claffey J; Cuffe S; Fichtner I; Pampillon C; Sweeney NJ; Strohfeldt K; Watson RW; Tacke M
Antitumor activity of Titanocene Y in xenografted PC3 tumors in mice
Letters in Drug Design & Discovery 5 (2): 141-144 (2008-03)
Fichtner I; Behrens D; Claffey J; Gleeson B; Hogan M; Wallis D; Weber H; Tacke M
Antitumor activity of oxali-titanocene Y in xenografted CAKI-1 tumors in mice
Letters in Drug Design & Discovery 5 (8): 489-493 (2008-12)
Stein U; Walther W; Stege A; Kaszubiak A; Fichtner I; Lage H
Complete in vivo reversal of the multidrug resistance phenotype by jet-injection of anti-MDR1 short hairpin RNA-encoding plasmid DNA
Molecular Therapy 16 (1): 178-186 (2008-01)
2007
Schmid B; Chung DE; Warnecke A; Fichtner I; Kratz F
Albumin-Binding Prodrugs of Camptothecin and Doxorubicin with an Ala-Leu-Ala-Leu-Linker That Are Cleaved by Cathepsin B: Synthesis and Antitumor Efficacy
Bioconjugate Chemistry 18 (3): 702-716 (2007-05)
Behrens D; Gill JH; Fichtner I
Loss of tumourigenicity of stably ERbeta-transfected MCF-7 breast cancer cells
Molecular and Cellular Endocrinology 274 (1-2): 19-29 (2007-08-15)
Behrens D; Lykkesfeldt AE; Fichtner I
The mTOR pathway inhibitor RAD001 (everolimus) is highly efficacious in tamoxifen-sensitive and -resistant breast cancer xenografts
Targeted Oncology 2 (3): 135-144 (2007-07)
Thirunarayanan N; Cifire F; Fichtner I; Posner S; Benga J; Reiterer P; Kremmer E; Koelble K; Lipp M
Enhanced tumorigenicity of fibroblasts transformed with human herpesvirus 8 chemokine receptor vGPCR by successive passage in nude and immunocompetent mice
Oncogene 26 (39): 5702-5712 (2007-08-23)
Yde CW; Frogne T; Lykkesfeldt AE; Fichtner I; Issinger OG; Stenvang J
Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT
Cancer Letters 256 (2): 229-237 (2007-10-28)
Warnecke A; Fichtner I; Sass G; Kratz F
Synthesis, Cleavage Profile, and Antitumor Efficacy of an Albumin-Binding Prodrug of Methotrexate that is Cleaved by Plasmin and Cathepsin B
Archiv der Pharmazie 340 (8): 389-395 (2007-08)
Zeisig R; Koklic T; Wiesner B; Fichtner I; Sentjurc M
Increase in fluidity in the membrane of MT3 breast cancer cells correlates with enhanced cell adhesion in vitro and increased lung metastasis in NOD/SCID mice
Archives of Biochemistry and Biophysics 459 (1): 98-106 (2007-03-01)
Schmid B; Warnecke A; Fichtner I; Jung M; Kratz F
Development of albumin-binding camptothecin prodrugs using a peptide positional scanning library
Bioconjugate Chemistry 18 (6): 1786-1799 (2007-11)
Bannon JH; Fichtner I; O'Neill A; Pampillon C; Sweeney NJ; Strohfeldt K; Watson RW; Tacke M; McGee MM
Substituted titanocenes induce caspase-dependent apoptosis in human epidermoid carcinoma cells in vitro and exhibit antitumour activity in vivo
British Journal of Cancer 97 (9): 1234-1241 (2007-11-05)
Bijnsdorp IV; Schwendener RA; Schott H; Fichtner I; Smid K; Schott S; Laan AC; Peters GJ
In vivo and in vitro activity and mechanism of action of the multidrug cytarabine-L-glycerylyl-fluorodeoxyuridine
Nucleosides Nucleotides & Nucleic Acids 26 (10-12): 1619-24 (2007)
Walther W; Arlt F; Fichtner I; Aumann J; Stein U; Schlag PM
Heat-inducible in vivo gene therapy of colon carcinoma by human mdr1 promoter-regulated tumor necrosis factor-alpha expression
Molecular Cancer Therapeutics 6: 236-243 (2007-01-01)
Kaufner L; Cartier R; Wuestneck R; Fichtner I; Pietschmann S; Bruhn H; Schuett D; Thuenemann AF; Pison U
Poly(ethylene oxide)-block-poly(glutamic acid) coated maghemite nanoparticles: in vitro characterization and in vivo behaviour
Nanotechnology 18 (11): 115710 (2007-03-21)
2006
Walther W; Minow T; Martin R; Fichtner I; Schlag PM; Stein U
Uptake, biodistribution, and time course of naked plasmid DNA trafficking after intratumoral in vivo jet injection
Human Gene Therapy 17 (6): 611-624 (2006-06)
Schanzer JM; Fichtner I; Baeuerle PA; Kufer P
Antitumor activity of a dual cytokine/single-chain antibody fusion protein for simultaneous delivery of GM-CSF and IL-2 to Ep-CAM expressing tumor cells
Journal of Immunotherapy 29: 477-488 (2006-09-01)
Brischwein K; Schlereth B; Guller B; Steiger C; Wolf A; Lutterbuese R; Offner S; Locher M; Urbig T; Raum T; Kleindienst P; Wimberger P; Kimmig R; Fichtner I; Kufer P; Hofmeister R; da Silva AJ; Baeuerle PA
MT110: A novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors
Molecular Immunology 43: 1129-1143 (2006-01-01)
Shalapour S; Zelmer A; Pfau M; Moderegger E; Costa-Blechschmidt C; van Landeghem FK; Taube T; Fichtner I; Buehrer C; Henze G; Seeger K; Wellmann S
The thalidomide analogue, CC-4047, induces apoptosis signaling and growth arrest in childhood acute lymphoblastic leukemia cells in vitro and in vivo
Clinical Cancer Research 12: 5526-5532 (2006-09-15)
Einsiedel HG; Kawan L; Eckert C; Witt O; Fichtner I; Henze G; Seeger K
Histone deacetylase inhibitors have antitumor activity in two NOD/SCID mouse models of B-cell precursor childhood acute lymphoblastic leukemia
Leukemia 20: 1435-1436 (2006-08-01)
Fichtner I; Pampillon C; Sweeney NJ; Strohfeldt K; Tacke M
Anti-tumor activity of Titanocene Y in xenografted Caki-1 tumors in mice
Anti-Cancer Drugs 17 (3): 333-336 (2006-03)
Besada V; Diaz M; Becker M; Ramos Y; Castellanos-Serra L; Fichtner I
Proteomics of xenografted human breast cancer indicates novel targets related to tamoxifen resistance
Proteomics 6 (3): 1038-1048 (2006-02)
Schlereth B; Kleindienst P; Fichtner I; Lorenczewski G; Brischwein K; Lippold S; Silva AD; Locher M; Kischel R; Lutterbuese R; Kufer P; Baeuerle PA
Potent inhibition of local and disseminated tumor growth in immunocompetent mouse models by a bispecific antibody construct specific for Murine CD3
Cancer Immunology Immunotherapy 55: 785-796 (2006-07-01)
Michaelis M; Fichtner I; Behrens D; Haider W; Rothweiler F; Mack A; Cinatl J; Doerr HW; Cinatl J Jr
Anti-cancer effects of bortezomib against chemoresistant neuroblastoma cell lines in vitro and in vivo
International Journal of Oncology 28: 439-446 (2006-02-01)
2005
Carstanjen D; Gross A; Kosova N; Fichtner I; Salama A
The alpha4beta1 and alpha5beta1 integrins mediate engraftment of granulocyte-colony-stimulating factor-mobilized human hematopoietic progenitor cells
Transfusion 45: 1192-1200 (2005-07-01)
Henschler R; Goettig S; Junghahn I; Bug G; Seifried E; Mueller AM; Fichtner I
Transplantation of human acute myeloid leukemia (AML) cells in immunodeficient mice reveals altered cell surface phenotypes and expression of human endothelial markers
Leukemia Research 29: 1191-1199 (2005-01-01)
Schlereth B; Fichtner I; Lorenczewski G; Kleindienst P; Brischwein K; da Silva A; Kufer P; Lutterbuese R; Junghahn I; Kasimir-Bauer S; Wimberger P; Kimmig R; Baeuerle PA
Eradication of tumors from a human colon cancer cell line and from ovarian cancer metastases in immunodeficient mice by a single-chain Ep-CAM-/CD3-bispecific antibody construct
Cancer Research 65: 2882-2889 (2005-01-01)
Mravljak J; Zeisig R; Pecar S
Synthesis and biological evaluation of spin-labeled alkylphospholipid analogs
Journal of Medicinal Chemistry 48: 6393-6399 (2005-10-06)
Keil C; Zeisig R; Fichtner I
Effect of surface modified liposomes on the aggregation of platelets and tumor cells
Thrombosis and Haemostasis 94 (2): 404-411 (2005-08)
Sharma AD; Cantz T; Richter R; Eckert K; Henschler R; Wilkens L; Jochheim-Richter A; Arseniev L; Ott M
Human cord blood stem cells generate human cytokeratin 18-negative hepatocyte-like cells in injured mouse liver
American Journal of Pathology 167: 555-564 (2005-08-01)
Walther W; Stein U; Fichtner I; Kobelt D; Aumann J; Arlt F; Schlag PM
Nonviral jet-injection gene transfer for efficient in vivo cytosine deaminase suicide gene therapy of colon carcinoma
Molecular Therapy 12: 1176-1184 (2005-09-29)
Berry JM; Bradshaw TD; Fichtner I; Ren R; Schwalbe CH; Wells G; Chew EH; Stevens MF; Westwell AD
Quinols as novel therapeutic agents. 2.(1) 4-(1-arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents
Journal of Medicinal Chemistry 48: 639-644 (2005-01-27)
Koklic T; Pirs M; Zeisig R; Abramovic Z; Sentjurc M
Membrane switch hypothesis. 1. Cell density influences lateral domain structure of tumor cell membranes
Journal of Chemical Information and Modeling 45: 1701-1707 (2005-11-28)
Kratz F; Mansour A; Soltau J; Warnecke A; Fichtner I; Unger C; Drevs J
Development of albumin-binding doxorubicin prodrugs that are cleaved by prostate-specific antigen
Archiv der Pharmazie 338: 462-472 (2005-10-07)
Becker M; Sommer A; Kraetzschmar JR; Seidel H; Pohlenz HD; Fichtner I
Distinct gene expression patterns in a tamoxifen-sensitive human mammary carcinoma xenograft and its tamoxifen-resistant subline MaCa 3366/TAM
Molecular Cancer Therapeutics 4: 151-170 (2005-01-01)
Walther W; Stein U; Siegel R; Fichtner I; Schlag PM
Use of the nuclease inhibitor aurintricarboxylic acid (ATA) for improved non-viral intratumoral in vivo gene transfer by jet-injection
Journal of Gene Medicine 7: 477-485 (2005-01-01)
2004
Fichtner I; Becker M; Besada V; Castellanos-Serra L
Differential protein expression pattern in tamoxifen-sensitive and -resistant breast cancer xenografts
International Journal of Clinical Pharmacology and Therapeutics 42 (11): 632-634 (2004-11)
Warnecke A; Fichtner I; Garmann D; Jaehde U; Kratz F
Synthesis and biological activity of water-soluble maleimide derivatives of the anticancer drug Carboplatin designed as albumin-binding prodrugs
Bioconjugate Chemistry 15: 1349-1359 (2004-11-01)
Fichtner I; Becker M; Zeisig R; Sommer A
In vivo models for endocrine-dependent breast carcinomas: special considerations of clinical relevance
European Journal of Cancer 40: 845-851 (2004-01-01)
Walther W; Stein U; Fichtner I; Schlag PM
Low-volume jet injection for efficient nonviral in vivo gene transfer
Molecular Biotechnology 28: 121-128 (2004-01-01)
Zeisig R; Teppke AD; Behrens D; Fichtner I
Liposomal 4-hydroxy-tamoxifen: effect on cellular uptake and resulting cytotoxicity in drug resistant breast cancer cells in vitro
Breast Cancer Research and Treatment 87: 245-254 (2004-01-01)
Fichtner I; Monks A; Hose C; Stevens MF; Bradshaw TD
The experimental antitumor agents phortress and doxorubicin are equiactive against human-derived breast carcinoma xenograft models
Breast Cancer Research and Treatment 87: 97-107 (2004-09-01)
Varvaresou A; Iakovou K; Gikas E; Fichtner I; Fiebig HH; Kelland LR; Double JA; Bibby MC; Hendriks HR
Antitumor activity of imidazothioxanthones in murine and human tumor models in vitro and in vivo
Anticancer Research 24: 907-919 (2004-01-01)
Zeisig R; Stahn R; Wenzel K; Behrens D; Fichtner I
Effect of sialyl Lewis X-glycoliposomes on the inhibition of E-selectin-mediated tumour cell adhesion in vitro
Biochimica et Biophysica Acta - Biomembranes 1660: 31-40 (2004-01-01)
Zeisig R; Rueckerl D; Fichtner I
Reduction of tamoxifen resistance in human breast carcinomas by tamoxifen-containing liposomes in vivo
Anti-Cancer Drugs 15: 707-714 (2004-08-01)
Fichtner I; Slisow W; Gill J; Becker M; Elbe B; Hillebrand T; Bibby M
Anticancer drug response and expression of molecular markers in early-passage xenotransplanted colon carcinomas
European Journal of Cancer 40: 298-307 (2004-01-01)
2003
Mansour AM; Drevs J; Esser N; Hamada FM; Badary OA; Unger C; Fichtner I; Kratz F
A new approach for the treatment of malignant melanoma: Enhanced antitumor efficacy of an albumin-binding doxorubicin prodrug that is cleaved by matrix metalloproteinase 2
Cancer Research 63: 4062-4066 (2003-01-01)
Dreier T; Baeuerle PA; Fichtner I; Gruen M; Schlereth B; Lorenczewski G; Kufer P; Lutterbuese R; Riethmueller G; Gjorstrup P; Bargou RC
T cell costimulus-independent and very efficacious inhibition of tumor growth in mice bearing subcutaneous or leukemic human B cell lymphoma xenografts by a CD19-/CD3-bispecific single-chain antibody construct1
Journal of Immunology 170 (8): 4397-4402 (2003-01-01)
Fichtner I; Paal K; Borgmann A; Badiali L; Wurm R; Henze G
Chemo- and radiation sensitivity of xenografted acute lymphoblastic leukemias-correlation to the expression of multidrug resistance proteins
Anticancer Research 23: 2657-2664 (2003-01-01)
Fichtner I; Reszka R; Arndt D; Zeisig R
Animal experiments - An essential component for the development of liposomal anticancer agents
Journal of Liposome Research 13: 9-15 (2003-01-01)
Erben U; Thiel E; Bittroff-Leben A; Schoch C; Fichtner I; Durkop H; Notter M
CS-1, a novel c-kithi+ acute myeloid leukemia cell line with dendritic cell differentiation capacity and absent immunogenicity
International Journal of Cancer 105 (2): 232-240 (2003-01-01)
Fichtner I; Becker M; Baumgart J
Antileukaemic activity of treosulfan in xenografted human acute lymphoblastic leukaemias (ALL)
European Journal of Cancer 39: 801-807 (2003-01-01)
Nitsche A; Junghahn I; Thulke S; Aumann J; Radonic A; Fichtner I; Siegert W
Interleukin-3 promotes proliferation and differentiation of human hematopoietic stem cells but reduces their repopulation potential in NOD/SCID mice
Stem Cells 21: 236-244 (2003-01-01)
Zeisig R; Ress A; Fichtner I; Walther W
Lipoplexes with alkylphospholipid as new helper lipid for efficient in vitro and in vivo gene transfer in tumor therapy
Cancer Gene Therapy 10: 302-311 (2003-01-01)
2002
Harder F; Henschler R; Junghahn I; Lamers MC; Mueller AM
Human hematopoiesis in murine embryos after injecting human cord blood-derived hematopoietic stem cells into murine blastocysts
Blood 99: 719-721 (2002-01-15)
Naundorf S; Preithner S; Mayer P; Lippold S; Wolf A; Hanakam F; Fichtner I; Kufer P; Raum T; Riethmueller G; Baeuerle PA; Dreier T
In vitro and in vivo activity of MT201, a fully human monoclonal antibody for pancarcinoma treatment
International Journal of Cancer 100: 101-110 (2002-07-01)
Brunner N; Double J; Fichtner I; Gescher A; Newell D; Oosterhuis W; Price P
The EORTC Laboratory Research Division
European Journal of Cancer 38: S14-S18 (2002-01-01)
Zeisig R; Stahn R; Fichtner I
Inhibition of carbohydrate mediated cell adhesion by liposomes as a possible way to prevent tumour metastasis
Cellular and Molecular Biology Letters 7: 270-271 (2002-01-01)
Koklic T; Sentjurc M; Zeisig R
The influence of cholesterol and charge on the membrane domains of alkylphospholipid liposomes as studied by EPR
Journal of Liposome Research 12: 335-352 (2002-01-01)
Bradshaw TD; Bibby MC; Double JA; Fichtner I; Cooper PA; Alley MC; Donohue S; Stinson SF; Tomaszewjski JE; Sausville EA; Stevens MFG
Preclinical evaluation of amino acid prodrugs of novel antitumor 2-(4-amino-3-methylphenyl)benzothiazoles
Molecular Cancer Therapeutics 1: 239-246 (2002-01-01)
Walther W; Stein U; Fichtner I; Voss C; Schmidt T; Schleef M; Nellessen T; Schlag PM
Intratumoral low-volume jet-injection for efficient nonviral gene transfer
Molecular Biotechnology 21: 105-115 (2002-06-01)
Kratz F; Warnecke A; Scheuermann K; Stockmar C; Schwab J; Lazar P; Drueckes P; Esser N; Drevs J; Rognan D; Bissantz C; Hinderling C; Folkers G; Fichtner I; Unger C
Probing the cysteine-34 position of endogenous serum albumin with thiol-binding doxorubicin derivatives. Improved efficacy of an acid-sensitive doxorubicin derivative with specific albumin-binding properties compared to that of the parent compound
Journal of Medicinal Chemistry 45: 5523-5533 (2002-01-01)
Becker M; Nitsche A; Neumann C; Aumann J; Junghahn I; Fichtner I
Sensitive PCR method for the detection and real-time quantification of human cells in xenotransplantation systems
British Journal of Cancer 87: 1328-1335 (2002-01-01)
2001
Zeisig R; Caemmerer B
Liposomes in the food industry
Mircoencapsulation of Food Ingredients : 101-119 (2001-01-01)
Fulda S; Fichtner I; Hero B; Berthold F
Preclinical and clinical aspects on the use of amifostine as chemoprotectorin neuroblastoma patients
Medical and Pediatric Oncology 36: 199-202 (2001-01-01)
Arndt D; Zeisig R; Bechtel D; Fichtner I
Liposomal bleomycin: increased therapeutic activity and decreased pulmonary toxicity in mice
Drug Delivery 8: 1-7 (2001-01-01)
Pecher G; Harnack U; Guenther M; Hummel M; Fichtner I; Schenk JA
Generation of an immortalized human CD4+ T cell clone inhibiting tumor growth in mice
Biochemical and Biophysical Research Communications 283: 738-742 (2001-01-01)
Kisseleva E; Becker M; Lemm M; Fichtner I
Early macrophage and cytokine response during the growth of immunogenic and non-immunogenic murine tumors
Anticancer Research 21: 3477-3484 (2001-01-01)
Lode J; Fichtner I; Kreuter J; Berndt A; Diederichs JE; Reszka R
Influence of surface-modifying surfactants on the pharmacokinetic behavior of 14C-poly (methylmethacrylate) nanoparticles in experimental tumor models
Pharmaceutical Research 18: 1613-1619 (2001-01-01)
Stahn R; Grittner C; Zeisig R; Karsten U; Felix SB; Wenzel K
Sialyl Lewisx-liposomes as vehicles for site-directed, E-selectin-mediated drug transfer into activated endothelial cells
Cellular and Molecular Life Sciences 58: 141-147 (2001-01-01)
Zeisig R; Mueller K; Maurer N; Arndt D; Fahr A
The composition-dependent presence of free (micellar) alkylphospholipid in liposomal formulations of octadecyl-1,1-dimethyl-piperidino-4-yl-phosphate affects its cytotoxic activity in vitro
Journal of Membrane Biology 182: 61-69 (2001-01-01)
Zeisig R; Stahn R; Teppke AD; Arndt D
Cancerostatic octadecylpiperidinoylphosphate liposomes: effect of composition on uptake by and toxicity to J774 mouse macrophage cells and MT1 breast cancer cells in vitro
Anti-Cancer Drug Design 16: 19-26 (2001-01-01)
Walther W; Stein U; Fichtner I; Malcherek L; Lemm M; Schlag PM
Nonviral in vivo gene delivery into tumors using a novel low volume jet-injection technology
Gene Therapy 8: 173-180 (2001-01-01)
Araujo RC; Kettritz R; Fichtner I; Paiva ACM; Pesquero JB; Bader M
Altered neutrophil homeostasis in kinin B1 receptor deficient mice
Biological Chemistry 382: 91-95 (2001-01-01)
Walther W; Stein U; Fichtner I; Schlag PM
In vivo Gentransfer nackter DNA in xenotransplantierte Kolonkarzinome in der Nude Maus mit Hilfe der Jet-Injektion [In vivo gene transfer of naked DNA into xenotransplanted colon carcinoma by jet-injection]
Chirurgisches Forum 30: 69-72 (2001-01-01)
Roemer I; Vogel T; Otto A; Fichtner I; Klose J
Analysis of mouse beta-haptoglobin chain by lectin affinoblotting detection
Electrophoresis 22: 3038-3042 (2001-01-01)
Nitsche A; Becker M; Junghahn I; Aumann J; Landt O; Fichtner I; Wittig B; Siegert W
Quantification of human cells in NOD/SCID mice by duplex real-time polymerase reaction
Haematologica 86: 693-699 (2001-01-01)
2000
Warda M; Zeisig R
Phospholipid- and fatty acid-composition in the erythrocyte membrane of the one-humped camel [Camelus dromedarius] and its influence on vesicle properties prepared from these lipids
Deutsche Tieraerztliche Wochenschrift 107 (9): 368-373 (2000-09-01)
Kratz F; Roth T; Fichtner I; Schumacher P; Fiebig HH; Unger C
In vitro and in vivo efficacy of acid-sensitive transferrin and albumin doxorubicin conjugates in a human xenograft panel and in the MDA-MB-435 mamma carcinoma model
Journal of Drug Targeting 8: 305-318 (2000-01-01)
Horber DH; Cattaneo-Pangrazzi RMC; von Ballmoos P; Schott H; Ludwig PS; Eriksson S; Fichtner I; Schwendener RA
Cytotoxicity, cell-cycle perturbations and apoptosis in human tumor cells by lipophilic N4-alkyl-1-beta-D-arabinofuranosylcytosine derivatives and the new heteronucleoside phosphate dimer arabinocytidylyl-(5' -> 5')-N4-octadecyl-1-beta-d-arabinofuranosylcytosine
Journal of Cancer Research and Clinical Oncology 126: 311-319 (2000-01-01)
Goan SR; Junghahn I; Wissler M; Becker M; Aumann J; Just U; Martiny-Baron G; Fichtner I; Henschler R
Donor stromal cells from human blood engraft in NOD/SCID mice
Blood 96: 3971-3978 (2000-12-01)
Borgmann A; Baldy C; von Stackelberg A; Beyermann B; Fichtner I; Nuernberg P; Henze G
Childhood all blasts retain phenotypic and genotypic characteristics upon long-term serial passage in NOD/SCID mice
Pediatric Hematology and Oncology 17: 635-650 (2000-12-01)
Naundorf H; Becker M; Lykkesfeldt AE; Elbe B; Neumann C; Buttner B; Fichtner I
Development and characterization of a tamoxifen resistant breast carcinoma xenograft
British Journal of Cancer 82: 1844-1850 (2000-06-01)
Naundorf H; Jost-Reuhl B; Becker M; Reuhl T; Neumann C; Fichtner I
Differences in immunoreactivity of estrogen receptor (ER) in tamoxifen-sensitive and -resistant breast carcinomas: preclinical and first clinical investigations
Breast Cancer Research and Treatment 60: 81-92 (2000-03-01)
Walther W; Stein U; Fichtner I; Alexander M; Shoemaker RH; Schlag PM
mdr1 promoter-driven tumor necrosis factor-alpha expression for a chemotherapy-controllable combined in vivo gene therapy and chemotherapy of tumors
Cancer Gene Therapy 7: 893-900 (2000-06-01)
Stahn R; Zeisig R
Cell adhesion inhibition by glycoliposomes: Effects of vesicle diameter and ligand density
Tumor Biology 21: 176-186 (2000-05-01)
1999
Dehmel A; Becker M; Lemm M; Fichtner I
Expression of CD44 isoforms in human breast carcinoma xenografts is not influenced by the treatment of mice with cytostatics or (anti-) hormones
Anticancer Research 19: 1977-1987 (1999-05-01)
Hoffmann J; Schmidt-Peter P; Haensch W; Naundorf H; Bunge A; Becker M; Fichtner I
Anticancer drug sensitivity and expression of multidrug resistance markers in early passage human sarcomas
Clinical Cancer Research 5: 2198-2204 (1999-08-01)
Mrowietz U; Schwenk U; Maune S; Bartels J; Kuepper M; Fichtner I; Schroeder J-M; Schadendorf D
The chemokine RANTES is secreted by human melanoma cells and is associated with enhanced tumour formation in nude mice
British Journal of Cancer 79: 1025-1031 (1999-01-01)
Fichtner I; Goan SR; Becker M; Baldy C; Borgmann A; von Stackelberg A; Henze H
Transplantation of human haematopoietic or leukaemic cells into SCID and NOD/SCID mice
Relevance of Tumor Models for Anticancer Drug Development : 207-217 (1999-01-01)
Goan SR; Junghahn I; Fichtner I; Becker M; Just U; Moebest D; Henschler R
Ex vivo expanded CD34+ blood progenitor cells display lymphomyeloid plus stromal cell differentiation potential after transplantation into NOD/SCID mice
Relevance of Tumor Models for Anticancer Drug Development : 219-232 (1999-01-01)
Arndt D; Zeisig R; Fichtner I; Teppke AD; Fahr A
Pharmacokinetics of sterically stabilized hexadecylphosphocholine liposomes versus conventional liposomes and free hexadecylphosphocholine in tumor-free and human breast carcinoma bearing mice
Breast Cancer Research and Treatment 58: 71-80 (1999-11-01)
Mobest D; Goan SR; Junghahn I; Winkler J; Fichtner I; Hermann V; Becker M; de Lima-Hahn E; Henschler R
Differential kinetics of primitive hematopoietic cells assayed in vitro and in vivo during serum-free suspension culture of CD34+ blood progenitor cells
Stem Cells 17: 152-161 (1999-01-01)
1998
Walther W; Stein U; Fichtner I; Shoemaker RH; Alexander M; Schlag PM
In vivo evaluation of a cytostatic drug-inducible vector for the expression of TNF-alpha
Proceedings of the American Association of Cancer Research 39: 520 (1998-01-01)
Walther W; Stein U; Fichtner I; Naundorf H; Alexander M; Shoemaker RH; Schlag PM
In vivo evaluation of a drug-inducible vector system for the combined gene and chemotherapy of cancer
Cancer Gene Therapy : 139-144 (1998-01-01)
Arndt D; Zeisig R; Fichtner I
Alkylphospholipid liposomes: Preparation, properties and use in cancer research
Drugs of Today 34 Suppl. F: 83-96 (1998-12-01)
Brachwitz H; Bergmann J; Fichtner I; Thomas Y; Vollgraf C; Langen P; Berdel WE
1-beta-D-Arabinofuranosylcytosine-5'-alkylphosphonophosphates and diphosphates: new orally active derivatives of ara-C
Journal of Lipid Research 39: 162-172 (1998-01-01)
Zeisig R; Arndt D; Stahn R; Fichtner I
Physical properties and pharmacological activity in vitro and in vivo of optimised liposomes prepared from a new cancerostatic alkylphospholipid
Biochimica et Biophysica Acta - Biomembranes 1414 (1-2): 238-248 (1998-11-11)
Fabian H; Wessel R; Jackson M; Schwartz A; Lasch P; Fichtner I; Mantsch HH; Naumann D
IR-spectroscopy and IR-microscopy of human breast tumors, xenografted breast tumors, and breast tumor cell lines
Infrared Spectroscopy: New Tool in Medicine. Proceedings of Infrared Spectroscopy: New Tool in Medicine : 28-30 January 1998, San Jose, California : [s.p.] (1998-01-01)
1997
Stein U; Walther W; Lemm M; Naundorf H; Fichtner I
Development and characterization of novel human multidrug resistant mammary carcinoma lines in vitro and in vivo
International Journal of Cancer 72: 885-891 (1997-01-01)
Reszka R; Beck P; Fichtner I; Hentschel M; Richter J; Kreuter J
Body distribution of free, liposomal and nanoparticle-associated mitoxantrone in B16-melanoma-bearing mice
Journal of Pharmacology and Experimental Therapeutics 280: 232-237 (1997-01-01)
Arndt D; Zeisig R; Eue I; Sternberg B; Fichtner I
Antineoplastic activity of sterically stabilized alkylphosphocholine liposomes in human breast carcinomas
Breast Cancer Research and Treatment 43: 237-246 (1997-01-01)
Reszka R; Fichtner I; Goan SR; Rudolph M; Winter R
Encapsulation of the transition metal compounds Carboplatin (CP) and Lobaplatin (LP) in different types ofliposomes and their physico-chemical, biochemical and biological characterization
Bioinorganic Chemistry - Transition Metals in Biology and their Coordination in Chemistry : 145-166 (1997-01-01)
Fichtner I; Lemm M; Becker M; Berthold F
Effects of amifostine (WR-2721, ethyol) on tumor growth and pharmacology of cytotoxic drugs in human xenotransplanted neuroblastomas
Anti-Cancer Drugs 8: 174-181 (1997-01-01)
Fichtner I; Dehmel A; Naundorf H; Finke LH
Expression of CD44 standard and isoforms in human breast cancer xenografts and shedding of soluble forms into serum of nude mice
Anticancer Research 17: 3633-3646 (1997-01-01)
Walther W; Stein U; Lemm M; Naundorf H; Fichtner I
Development and characterization of novel multidrug resistant breast cancer lines
Proceedings of the American Association of Cancer Research 38: 484 (1997-01-01)
Grabowska E; Eckert K; Fichtner I; Schulze-Forster K; Maurer HR
Bromelain proteases suppress growth, invasion and lung metastasis of B16F10 mouse melanoma cells
International Journal of Oncology 11: 243-248 (1997-01-01)
1996
Walther W; Stein U
Cell type specific and inducible promoters for vectors in gene therapy as an approach for cell targeting
Journal of Molecular Medicine 74: 379-392 (1996-01-01)
Arndt D; Eue I; Fichtner I; Zeisig R
Antineoplastic activity of alkylphosphocholines and alkylphosphochiline liposomes: A review of recent knowledge
: 141-144 (1996-01-01)
Naundorf H; Parczyk K; Zschiesche W; Reinecke S; Buettner B; Saul GJ; Sinn B; Fichtner I
Relation of oestradiol-mediated growth stimulation with the expression of c-erbB-2 protein in xenotransplanted oestradiol-receptor-positive and -negative breast carcinomas
Journal of Cancer Research and Clinical Oncology 122: 14-20 (1996-01-01)
Goan SR; Schwarz K; von Harsdorf S; von Schilling C; Fichtner I; Junghahn I; Just U; Herrmann F
Fibroblasts retrovirally transfected with the human IL-3 gene initiate and sustain multilineage human hematopoiesis in SCID mice: comparison of CD34-enriched vs CD34-enriched and in vitro expanded grafts
Bone Marrow Transplantation 18: 513-519 (1996-09-01)
Stein U; Walther W; Shoemaker RH
Vincristine induction of mutant and wild-type human multidrug-resitance promoters is cell- type-specific and dose-dependent
Journal of Cancer Research and Clinical Oncology 122: 275-282 (1996-01-01)
Shi DF; Bradshaw TD; Wrigley S; Mc Call CJ; Lelieveld P; Fichtner I; Stevens MFG
Antitumor benzothiazoles. 3.1Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo
Journal of Medicinal Chemistry 39: 3375-3384 (1996-01-01)
Walther W; Stein U; Wendt J; Shoemaker RH
Drug-inducible vector for the conditional expression of the human TNFalpha gene
Proceedings of the American Association of Cancer Research 37: 350 (1996-01-01)
Naundorf H; Zschiesche W; Reineke S; Saul GJ; Frege J; Buettner B; Fichtner I
Influence of estradiol and tamoxifen on the growth and regulation of C-erbB-2, estradiol and progesterone receptors of mammary carcinoma 3366 transplanted into nude mice
Immunodeficient Animals: Models for Cancer Research 51: 134-137 (1996-01-01)
Hoffmann J; Stein U; Schmidt-Peter P; Haensch W; Naundorf H; Scheper RJ; Fichtner I
Establishment and characterization of human sarcoma lines transplanted into nude mice
Immunodeficient Animals: Models for Cancer Research : 57-60 (1996-01-01)
Stein U; Shoemaker RH; Schlag PM
MDR1 gene expression: evaluation of its use asa molecular marker for prognosis and chemotherapy of bone and soft tissue sarcomas
European Journal of Cancer 32 A: 86-92 (1996-01-01)
Stein U; Walther W; Shoemaker RH
Reversal of multidrug resistance by transduction of cytokine genes into human colon carcinoma cells
Journal of the National Cancer Institute 88: 1383-1392 (1996-01-01)
Walther W; Stein U
Targeted vectors for gene therapy of cancer and retroviral infections
Molecular Biotechnology 6: 267-286 (1996-01-01)
Schadendorf D; Kern MA; Artuc M; Pahl HL; Rosenbach T; Fichtner I; Nuernberg W; Stueting S; von Stebut E; Worm M; Makki A; Jurgovsky K; Kolde G; Henz BM
Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro, and causes growth inhibition in xenografts in vivo
Journal of Cell Biology 135 (6 Pt 2): 1889-1898 (1996-12)
Goan SR; Fichtner I; Just J; Krause KP; Karawajew L; Schwarz K; von Harsdorf R; von Schilling C; Herrmann F
Peripheral blood stem cell-initiated human hematopoiesis in severe combined immunodeficient (SCID) mice is accelerated by a rat fibroblast cell line retrovirally transfected with the human IL-3 gene
Immunodeficient Animals: Models of Cancer Research : 171-175 (1996-01-01)
Vogel T; Dehmel A; Otto A; Fichtner I; Kaisers H; Schlag PM
Detektion Mamma-Karzinom-spezifischer Proteine aus dem Serum xenotransplantierter Nacktmaeuse mittels differentieller zweidimensionaler Elektrophorese
Langenbecks Archiv fuer Chirurgie Suppl.I: 537-542 (1996-01-01)
Fichtner I; Naundorf H; Saul GJ; Zschiesche W; Zeisig R
Establishment and characterization of human xenotransplanted breast carcinoma lines: use for the screening of alkylphosphocholines (APC)
Immunodeficient Animals: Models for Cancer Research 51: 129-133 (1996-01-01)
Zeisig R; Fichtner I; Arndt D
Preparation and properties of alkylphospholipid liposomes: a review
Cellular and Molecular Biology Letters 1: 447-457 (1996-01-01)
Bargou RC; Mapara MY; Arnold W; Daniel PT; Doerken B
Xenotransplantation of a novel hodgkin cell line HD-MyZ into SCID mice
Immunodeficient Animals: Models in Cancer Research : 187-192 (1996-01-01)
Zschiesche W; Naundorf H; Reszka R; Saul GJ; Fichtner I
Effects of liposomes with defined fatty acid composition on xenotransplanted human mammary carcinomas
Immunodeficient Animals: Models for Cancer Research 51: 138-141 (1996-01-01)
Stein U; Walther W; Shoemaker H
Modulation of mdr1 expression by cytokines in human colon carcinoma cells: an approach for reversal of multidrug resistance
British Journal of Cancer 74: 1384-1391 (1996-01-01)
Schadendorf D; Fichtner I; Makki A; Alijagic S; Kuepper M; Mrowietz U; Henz BM
Metastatic potential of human melanoma cells in nude mice - characterization of phenotype, cytokine secretion and tumour-associated antigens
British Journal of Cancer 74: 194-199 (1996-01-01)
Kisseleva E; Becker M; Lemm M; Fichtner I
Involvement of macrophages and cytokines into rejection mechanism of the drug-resistant and immunogenic murine lymphoma P388/adria
Anticancer Research 16: 1971-1978 (1996-01-01)
Zeisig R; Eue I; Kosch M; Fichtner I; Arndt D
Preparation and properties of sterically stabilized hexadecylphosphochiline (miltefosine)-liposomes and influence of this modification on macrophage activation
Biochimica et Biophysica Acta 1283: 177-184 (1996-01-01)
Arnold W; Koepf-Maier P; Micheel B
Immunodeficient Animals: Models for Cancer Research
: (1996-01-01)
1995
Fabian H; Jackson M; Murphy L; Watson PH; Fichtner I; Mantsch HH
A comparative infrared spectroscopic study of human breast tumors and breast tumor cell xenografts
Biospectroscopy 1: 37-45 (1995-01-01)
Goan SR; Fichtner I; Just U; Karawajew L; Schultze W; Krause KP; von Harsdorf S; von Schilling C; Herrmann F
The severe combined immunodeficient-human peripheral blood stem cell (SCID-huPBSC) mouse: a xenotransplant model for huPBSC-initiated hematopoiesis
Blood 86 (1): 89-100 (1995-07-01)
Naundorf H; Zschiesche W; Reszka R; Fichtner I
Influence of liposomes rich in unsaturated or saturated fatty acids on the growth of human xenotransplanted mammary carcinomas and on the levels of heart type fatty acid binding protein
In Vivo 9: 247-252 (1995-01-01)
Fichtner I; Reszka R; Goan SR; Naundorf H
Carboplatin-liposomes (CPL) in immunodeficient mice: improved antitumor activity for breast carcinomas and stimulationof hematopoiesis
Medical Oncology 11: 111-119 (1995-01-01)
Zeisig R; Jungmann S; Eue I; Daemen T; Fichtner I; Nissen E; Arndt D
Macrophage mediated tumor toxicity of alkylphosphocholine liposomes
Phospholipids: Characterization, Metabolism, and Novel Biological Applications : Proceedings of the 6th International Colloquium : 126-133 (1995-01-01)
Fichtner I; Reszka R; Goan SR; Naundorf H; Hentschel M
Pharmacological effects of carboplatin-liposomes (CPL) in mice: a review of present knowledge
Journal of Liposome Research 5: 75-89 (1995-01-01)
Walther W; Stein U; Pfeil D
Gene transfer of human TNFalpha into glioblastoma cells permits modulation of mdr1 expression and potentiation of chemosensitivity
International Journal of Cancer 61 (6): 832-839 (1995-01-01)
Arndt D; Zeisig R; Eue I; Fichtner I
Alkylphosphocholines and alkylphosphocholine liposomes
Journal of Liposome Research 5: 91-98 (1995-01-01)
1994
Fichtner I; Zeisig R; Naundorf H; Jungmann S; Arndt D; Asongwe G; Double JA; Bibby MC
Antineoplastic activity of alkylphosphocholines (APC) in human breast carcinomas in vivo and in vitro: use of liposomes
Breast Cancer Research and Treatment 32: 269-279 (1994-01-01)
Eue I; Zeisig R; Jungmann S; Fichtner I; Arndt D
Immunmodyfying properties of free and liposomal alkylphosphocholines
European Journal of Cell Biology 63: 16-16 (1994-01-01)
Naundorf H; Fichtner I; Elbe B; Saul GJ; Haensch W; Zschiesche W; Reinecke S
Establishment and characteristics of two new human mammary carcinoma lines in nude mice with special reference to the estradiol receptor status and the importance of stroma for in vivo and in vitro-growth
Breast Cancer Research and Treatment 32: 187-196 (1994-01-01)
Hoffmann J; Stein U; Schmidt-Peter P; Haensch W; Naundorf H; Fichtner I
Development and characterization of in vivo and in vitro tumor lines for investigation of the phenomenon of multidrug resistance in human sarcomas
Recent Advances in Chemotherapy. Proceedings of the 18th International Congress of Chemotherapy, Stockholm. : 885-887 (1994-01-01)
Uckert W; Asche O; Mahanty B; Fichtner I
Influence of different promoters on the expression of tumor necrosis factor alpha in LS174T human colon carcinoma cells
International Journal of Oncology 5: 865-871 (1994-01-01)
Pfeil D; Bergmann J; Fichtner I; Stein U; Hentschel M; Rothe I; Goan SR
Multidrug resistance of murine leukemia cells characterization and correlation with cytochrome P-450 dependent activities, cytosolic calcium and cell cycle state
Anticancer Research 14: 571-576 (1994-01-01)
Zeisig R; Jungmann S; Fichtner I; Daemen T; Arndt D
Cytotoxic effects of alkylphosphocholines or alkylphosphocholine-liposomes and macrophages on tumor cells
Anticancer Research 14: 1785-1790 (1994-01-01)
Fichtner I; Stein U; Hoffmann J; Winterfeld G; Pfeil D; Hentschel M
Characterization of four drug resistant P388 sublines: resistance/sensitivity in vivo, resistance- and proliferation-markers, immunogenicity
Anticancer Research 14: 1995-2004 (1994-01-01)
Fichtner I; Reszka R; Becker M; Lemm M; Richter J; Rudolph M
Stimulation of hematopoiesis by carboplatin-liposomes
Journal of Liposome Research 4 (1): 43-69 (1994-03)
1993
Walther W; Fichtner I; Uckert W
Retrovirus-mediated gene transfer of tumor necrosis factor alpha into colon carcinoma cells generates a growth inhibition
Anticancer Research 13: 1565-1574 (1993-01-01)
Beck P; Kreuter J; Reszka R; Fichtner I
Influence of polybutylcyanoacrylate nanoparticles and liposomes on the efficacy and toxicity of the anticancer drug mitoxantrone in murine tumour models
Journal of Microencapsulation 10: 101-114 (1993-01-01)
Naundorf H; Fichtner I; Saul GJ; Haensch W; Buettner B
Establishment and characteristics of two human mammary carcinoma lines serially transplantable in nude mice
Journal of Cancer Research and Clinical Oncology 119: 652-656 (1993-01-01)
Fichtner I; Reszka R; Schuett M; Rudolph M; Becker M; Lemm M; Richter J; Berger I
Carboplatin - liposomes as activators of hematopoiesis
Oncology Research 5: 65-74 (1993-01-01)
Fichtner I; Reipert B; Becker M; Lemm M
In vivo characterization of immunogenicity of a mitoxantrone-resistant murine P388 leukemia
In Vivo 7 (1): 73-80 (1993-01)
1992
Naundorf H; Fichtner I; Buettner B; Frege J
Establishment and characterization of a new human oestradiol- and progesteron-receptor-positive mammary carcinoma serially transplantable in nude mice
Journal of Cancer Research and Clinical Oncology 119: 35-40 (1992-01-01)
van Borssum Waalkes M; Fichtner I; Dontjes B; Lemm M; Becker M; Arndt D; Scherphof GL
In vivo distribution and antitumor activity of liposomal 3',5'-0-dipalmitoyl-5-fluoro-2'-deoxyuridine
Journal of Microencapsulation 9: 335-346 (1992-01-01)
Winterfeld G; Hauff P; Goerlich M; Arnold W; Fichtner I; Staab HJ
Investigations of droloxifene and other hormone manipulations on N-nitrosomethylurea-induced rat mammary tumors. 1. Influence on tumor growth
Journal of Cancer Research and Clinical Oncology 119: 91-96 (1992-01-01)
Fichtner I; Kniest A; Arndt D
Measurements of carbon clearance in mice as toxicity parameter for liposomal preparations
In Vivo 6: 113-118 (1992-01-01)
Goerlich M; Winterfeld G; Hauff P; Arnold W; Fichtner I; Staab HJ
Investigations of droloxifene and other hormonal manipulations on N-nitrosomethylurea- induced rat mammary tumors. 2. Influence on estrogen receptor
Journal of Cancer Research and Clinical Oncology 119: 97-100 (1992-01-01)
Naundorf H; Rewasowa EC; Fichtner I; Buettner B; Becker M; Goerlich M
Characterization of two human mammary carcinomas, MT-1 and MT-3, suitable for in vivo-testing of ether lipids and their derivatives
Breast Cancer Research and Treatment 23: 87-95 (1992-01-01)
1991
Hoffmann J; Fichtner I; Becker M; Lemm M
Messung der Bromsulfaleinretention der Maus als moeglicher Parameter zur Einschaetzung der Leberfunktion nach Gabe liposomaler Praeparationen
Pharmazie 46: 222-223 (1991-01-01)
Fichtner I; Arndt D; Reszka R; Gens J
Pharmacokinetic behavior of 57CO-Bleomycin liposomes in mice: comparison with the unencapsulated substance
Anti-Cancer Drugs 2: 555-563 (1991-01-01)
Ebert A; Fichtner I; Brandt R; Buettner B
Tierexperimentelle Untersuchungen mit dem Immunsuppressivum Cyclosporin A (CSA) an syngenen Tumormodellen
Archiv fuer Geschwulstforschung 61: 111-122 (1991-01-01)
Fichtner I
Stellenwert von Tierversuchen in der Onkologie. Moegliche Alternativen?
Archiv fuer Geschwulstforschung 61: 153-161 (1991-01-01)
Zeisig R; Fichtner I; Arndt D; Jungmann S
Antitumor effects of alkylphosphocholines in different murine tumor models, use of liposomal preparations
Anti-Cancer Drugs 2: 411-417 (1991-01-01)