Publikationen
2012
Schmidt V; Baum K; Lao A; Rateitschak K; Schmitz Y; Teichmann A; Wiesner B; Petersen CM; Nykjaer A; Wolf J; Wolkenhauer O; Willnow TE
Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease
EMBO Journal 31 (1): 187-200 (2012-01-04)
Fjorback AW; Seaman M; Gustafsen C; Mehmedbasic A; Gokool S; Wu C; Militz D; Schmidt V; Madsen P; Nyengaard JR; Willnow TE; Christensen EI; Mobley WB; Nykjaer A; Andersen OM
Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing
Journal of Neuroscience 32 (4): 1467-1480 (2012-01-25)
2011
Stuiver M; Lainez S; Will C; Terryn S; Guenzel D; Debaix H; Sommer K; Kopplin K; Thumfart J; Kampik NB; Querfeld U; Willnow TE; Nemec V; Wagner CA; Hoenderop JG; Devuyst O; Knoers NV; Bindels RJ; Meij IC; Mueller D
CNNM2, encoding a basolateral protein required for renal Mg(2+) handling, is mutated in dominant hypomagnesemia
American Journal of Human Genetics 88 (3): 333-343 (2011-03-11)
Vaegter CB; Jansen P; Fjorback AW; Glerup S; Skeldal S; Kjolby M; Richner M; Erdmann B; Nyengaard JR; Tessarollo L; Lewin GR; Willnow TE; Chao MV; Nykjaer A
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling
Nature Neuroscience 14 (1): 54-61 (2011-01)
2010
Amsellem S; Gburek J; Hamard G; Nielsen R; Willnow TE; Devuyst O; Nexo E; Verroust PJ; Christensen EI; Kozyraki R
Cubilin is essential for albumin reabsorption in the renal proximal tubule
Journal of the American Society of Nephrology 21 (11): 1859-1867 (2010-11)
Joutel A; Monet-Lepretre M; Gosele C; Baron-Menguy C; Hammes A; Schmidt S; Lemaire-Carrette B; Domenga V; Schedl A; Lacombe P; Huebner N
Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease
Journal of Clinical Investigation 120 (2): 433-445 (2010-02-01)
Kjolby M; Andersen OM; Breiderhoff T; Fjorback AW; Pedersen KM; Madsen P; Jansen P; Heeren J; Willnow TE; Nykjaer A
Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export
Cell Metabolism 12 (3): 213-223 (2010-09-08)
Zhang J; Piontek J; Wolburg H; Piehl C; Liss M; Otten C; Christ A; Willnow TE; Blasig IE; Abdelilah-Seyfried S
Establishment of a neuroepithelial barrier by Claudin5a is essential for zebrafish brain ventricular lumen expansion
Proceedings of the National Academy of Sciences of the United States of America 107 (4): 1425-1430 (2010-01-26)
2009
Ceccarini G; Flavell RR; Butelman ER; Synan M; Willnow TE; Bar-Dagan M; Goldsmith SJ; Kreek MJ; Kothari P; Vallabhajosula S; Muir TW; Friedman JM
PET imaging of leptin biodistribution and metabolism in rodents and primates
Cell Metabolism 10 (2): 148-159 (2009-08)
Rohe M; Synowitz M; Glass R; Paul SM; Nykjaer A; Willnow TE
Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression
Journal of Neuroscience 29 (49): 15472-15478 (2009-12-09)
Zabel C; Mao L; Woodman B; Rohe M; Wacker MA; Klaere Y; Koppelstaetter A; Nebrich G; Klein O; Grams S; Strand A; Luthi-Carter R; Hartl D; Klose J; Bates GP
A large number of protein expression changes occur early in life and precede phenotype onset in a mouse model for huntington disease
Molecular & Cellular Proteomics : MCP 8 (4): 720-734 (2009-04)
2008
Dodson SE; Andersen OM; Karmali V; Fritz JJ; Cheng D; Peng J; Levey AI; Willnow TE; Lah JJ
Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: Evidence for a proximal role in Alzheimer's disease
Journal of Neuroscience 28 (48): 12877-12886 (2008-11-26)
Willnow TE; Petersen CM; Nykjaer A
VPS10P-domain receptors - regulators of neuronal viability and function
Nature Reviews Neuroscience 9 (12): 899-909 (2008-12)
2007
Willnow TE; Hammes A; Eaton S
Lipoproteins and their receptors in embryonic development : more than cholesterol clearance
Development 134 (18): 3239-3249 (2007-09)
Jansen P; Giehl K; Nyengaard JR; Teng K; Lioubinski O; Sjoegaard SS; Breiderhoff T; Gotthardt M; Lin F; Eilers A; Petersen CM; Lewin GR; Hempstead BL; Willnow TE; Nykjaer A
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury
Nature Neuroscience 10 (11): 1449-1457 (2007-11)
Theilig F; Kriz W; Jerichow T; Schrade P; Hahnel B; Willnow TE; Le Hir M; Bachmann S
Abrogation of Protein Uptake through Megalin-Deficient Proximal Tubules Does Not Safeguard against Tubulointerstitial Injury
Journal of the American Society of Nephrology 18 (6): 1824-1834 (2007-06)
Rogaeva E; Meng Y; Lee JH; Gu Y; Kawarai T; Zou F; Katayama T; Baldwin CT; Cheng R; Hasegawa H; Chen F; Shibata N; Lunetta KL; Pardossi-Piquard R; Bohm C; Wakutani Y; Cupples LA; Cuenco KT; Green RC; Pinessi L; Rainero I; Sorbi S; Bruni A; Duara R; Friedland RP; Inzelberg R; Hampe W; Bujo H; Song YQ; Andersen OM; Willnow TE; Graff-Radford N; Petersen RC; Dickson D; Der SD; Fraser PE; Schmitt-Ulms G; Younkin S; Mayeux R; Farrer LA; St George-Hyslop P
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
Nature Genetics 39 (2): 168-177 (2007-02)
Nielsen R; Courtoy PJ; Jacobsen C; Dom G; Lima WR; Jadot M; Willnow TE; Devuyst O; Christensen EI
Endocytosis provides a major alternative pathway for lysosomal biogenesis in kidney proximal tubular cells
Proceedings of the National Academy of Sciences of the United States of America 104 (13): 5407-5412 (2007-03-27)
2006
Spoelgen R; von Arnim CA; Thomas AV; Peltan ID; Koker M; Deng A; Irizarry MC; Andersen OM; Willnow TE; Hyman BT
Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme
Journal of Neuroscience 26 (2): 418-428 (2006-01-11)
Andersen OM; Willnow TE
Lipoprotein receptors in Alzheimer's disease
Trends in Neurosciences 29 (12): 687-694 (2006-12)
Donath S; Li P; Willenbockel C; Al-Saadi N; Gross V; Willnow TE; Bader M; Martin U; Bauersachs J; Wollert KC; Dietz R; von Harsdorf R
Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress
Circulation 113: 1203-1212 (2006-02-27)
2005
Spoelgen R; Hammes A; Anzenberger U; Zechner D; Andersen OM; Jerchow B; Willnow TE
LRP2/megalin is required for patterning of the ventral telencephalon
Development 132: 405-414 (2005-01-01)
Nykjaer A; Willnow TE; Petersen CM
p75NTR - live or let die
Current Opinion in Neurobiology 15: 49-57 (2005-01-01)
Andersen OM; Reiche J; Schmidt V; Gotthardt M; Spoelgen R; Behlke J; von Arnim CAF; Breiderhoff T; Jansen P; Wu X; Bales KR; Cappai R; Masters CL; Gliemann J; Mufson EJ; Hyman BT; Paul SM; Nykjaer A; Willnow TE
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein
Proceedings of the National Academy of Sciences of the United States of America 102: 13461-13466 (2005-09-07)
Hammes A; Andreassen TK; Spoelgen R; Raila J; Huebner N; Schulz H; Metzger J; Schweigert FJ; Luppa PB; Nykjaer A; Willnow TE
Role of endocytosis in cellular uptake of sex steroids
Cell 122: 751-762 (2005-09-09)
2004
Nykjaer A; Lee R; Teng KK; Jansen P; Madsen P; Nielsen MS; Jacobsen C; Kliemannel M; Schwarz E; Willnow TE; Hempstead BL; Petersen CM
Sortilin is essential for proNGF-induced neuronal cell death
Nature 427 (6977): 843-848 (2004-02-26)
2003
Petersen HH; Hilpert J; Militz D; Zandler V; Jacobsen C; Roebroek AJM; Willnow TE
Functional interaction of megalin with the megalin-binding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule
Journal of Cell Science 116: 453-461 (2003-01-01)
Lisi S; Pinchera A; McCluskey RT; Willnow TE; Refetoff S; Marcocci C; Vitti P; Menconi F; Grasso L; Luchetti F; Collins AB; Marino M
Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: A control mechanism for thyroid hormone release
Proceedings of the National Academy of Sciences of the United States of America 100: 14858-14863 (2003-01-01)
Leheste JR; Melsen F; Wellner M; Jansen P; Schlichting U; Renner-Mueller I; Andreassen TT; Wolf E; Bachmann S; Nykjaer A; Willnow TE
Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect
FASEB Journal 17: 247-249 (2003-01-01)
2002
Nykjaer A; Willnow TE
The low-density lipoprotein receptor gene family: a cellular Swiss army knife?
Trends in Cell Biology 12 (6): 273-280 (2002-01-01)
Vetter R; Rehfeld U; Reissfelder C; Weiss W; Wagner KD; Gunther J; Hammes A; Tschoepe C; Dillmann W; Paul M
Transgenic overexpression of the sarcoplasmic reticulum Ca2+ ATPase improves reticular Ca2+ handling in normal and diabetic rat hearts
FASEB Journal 16: 1657-1659 (2002-01-01)
2001
Nykjaer A; Fyfe JC; Kozyraki R; Leheste JR; Jacobsen C; Nielsen MS; Verroust PJ; Aminoff M; de la Chapelle A; Moestrup SK; Ray R; Gliemann J; Willnow TE; Christensen EI
Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D-3
Proceedings of the National Academy of Sciences of the United States of America 98: 13895-13900 (2001-01-01)
Burmeister R; Boe IM; Nykjaer A; Jacobsen C; Moestrup SK; Verroust P; Christensen EI; Lund J; Willnow TE
A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney
Journal of Biological Chemistry 276: 13295-13301 (2001-01-01)
Kozyraki R; Fyfe J; Verroust PJ; Jacobsen C; Dautry-Varsat A; Gburek J; Willnow TE; Christensen EI; Moestrup SK
Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia
Proceedings of the National Academy of Sciences of the United States of America 98: 12491-12496 (2001-01-01)
2000
Sousa MM; Norden AGW; Jacobsen C; Willnow TE; Christensen EI; Thakker RV; Verroust PJ; Moestrup SK; Saraiva MJ
Evidence for the role of megalin in renal uptake of transthyretin
Journal of Biological Chemistry 275: 38176-38181 (2000-12-08)
Schmitz C; Gotthardt M; Hinderlich S; Leheste JR; Gross V; Vorum H; Christensen EI; Luft FC; Takahashi S; Willnow TE
Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor
Journal of Biological Chemistry 275: 15357-15362 (2000-05-19)
Birn H; Fyfe JC; Jacobsen C; Mounier F; Verroust PJ; Orskov H; Willnow TE; Moestrup SK; Christensen EI
Cubilin is an albumin binding protein important for renal tubular albumin reabsorption
Journal of Clinical Investigation 105 (10): 1353-1361 (2000-05)
1999
Hilpert J; Nykjaer A; Jacobsen C; Wallukat G; Nielsen R; Moestrup SK; Haller H; Luft FC; Christensen EI; Willnow TE
Megalin antagonizes activation of the parathyroid hormone receptor
Journal of Biological Chemistry 274 (9): 5620-5625 (1999-02-26)
Nykjaer A; Dragun D; Walther D; Vorum H; Jacobsen C; Herz J; Melsen F; Christensen EI; Willnow TE
An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D-3
Cell 96 (4): 507-515 (1999-02-19)
1998
Moestrup SK; Schousboe I; Jacobsen C; Leheste JR; Christensen EI; Willnow TE
beta(2)-glycoprotein-1 (apolipoprotein H) and beta(2)-glycoprotein-1-phospholipid complex harbor a recognition site for the endocytic receptor megalin
Journal of Clinical Investigation 102 (5): 902-909 (1998-09-01)
1997
Herz J; Willnow TE; Farese RV
Cholesterol, hedgehog and embryogenesis
Nature Genetics 15 (2): 123-124 (1997-02)
1996
Willnow TE; Hilpert J; Armstrong SA; Rohlmann A; Hammer RE; Burns DK; Herz J
Defective forebrain development in mice lacking gp330/megalin
Proceedings of the National Academy of Sciences of the United States of America 93 (16): 8460-8464 (1996-08-06)
Sinnis P; Willnow TE; Briones MR; Herz J; Nussenzweig V
Remnant lipoproteins inhibit malaria sporozoite invasion of hepatocytes
Journal of Experimental Medicine 184 (3): 945-954 (1996-09-01)
Willnow TE; Rohlmann A; Horton J; Otani H; Braun JR; Hammer RE; Herz J
RAP, a specialized chaperone, prevents ligand-induced er retention and degradation of LDL receptor-related endocytic receptors
EMBO Journal 15 (11): 2632-2639 (1996-01-01)
Braun JR; Willnow TE; Ishibashi S; Ashwell G; Herz J
The major subunit of the asialoglycoprotein receptor is expressed on the hepatocellular surface in mice lacking the minor receptor subunit
Journal of Biological Chemistry 271 (35): 21160-21166 (1996-08-30)
1995
Poller W; Willnow TE; Hilpert J; Herz J
Differential recognition of alpha1-antitrypsin-elastase and alpha1-antichymotrypsin-cathepsin G complexes by the low density lipoprotein receptor-related protein
Journal of Biological Chemistry 270 (6): 2841-2845 (1995-02-10)
Willnow TE; Armstrong SA; Hammer RE; Herz J
Functional expression of low density lipoprotein receptor- related protein is controlled by receptor-associated protein in vivo
Proceedings of the National Academy of Sciences of the United States of America 92 (10): 4537-4541 (1995-05-09)
1994
Willnow TE; Sheng Z; Ishibashi S; Herz J
Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist
Science 264 (5164): 1471-1474 (1994-06-03)
Willnow TE; Orth K; Herz J
Molecular dissection of ligand binding sites on the low density lipoprotein receptor-related protein
Journal of Biological Chemistry 269 (22): 15827-15832 (1994-06-03)
Orth K; Willnow TE; Herz J; Gething MJ; Sambrook J
Low density lipoprotein receptor-related protein is necessary for the internalization of both tissue-type plasminogen activator- inhibitor complexes and free tissue-type plasminogen activator
Journal of Biological Chemistry 269 (33): 21117-21122 (1994-08-19)