Publikationen
2012
Gherardi E; Birchmeier W; Birchmeier C; Woude GV
Targeting MET in cancer: rationale and progress
Nature Reviews Cancer 12 (2): 89-103 (2012-01-24)
Smith ESJ; Purfuerst B; Grigoryan T; Park TJ; Bennett NC; Lewin GR
A specific paucity of unmyelinated C-fibers in cutaneous peripheral nerves of the African naked-mole rat: A comparative analysis using six species of bathyergidae
Journal of Comparative Neurology : (2012-04-24)
Blackburn J; Ohazama A; Kawasaki K; Otsuka-Tanaka Y; Liu B; Honda K; Rountree RB; Hu Y; Kawasaki M; Birchmeier W; Schmidt-Ullrich R; Kinoshita A; Schutte BC; Hammond NL; Dixon MJ; Sharpe PT
The role of Irf6 in tooth epithelial invagination
Developmental Biology 365 (1): 61-70 (2012-05-01)
2011
Brembeck FH; Wiese M; Zatula N; Grigoryan T; Dai Y; Fritzmann J; Birchmeier W
BCL9-2 promotes early stages of intestinal tumor progression
Gastroenterology 141 (4): 1359-1370 (2011-10)
Birchmeier W
Stem cells: Orphan receptors find a home
Nature 476 (7360): 287-288 (2011-08-18)
Redmer T; Diecke S; Grigoryan T; Quiroga-Negreira A; Birchmeier W; Besser D
E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming
EMBO Reports 12 (7): 720-726 (2011-07-01)
Kuerbitz C; Heise D; Redmer T; Goumas F; Arlt A; Lemke J; Rimbach G; Kalthoff H; Trauzold A
Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells
Cancer Science 102 (4): 728-734 (2011-04)
Spagnoli FM; Besser D; Benitah SA
Where do you come from; where do you go? Pluripotency, differentiation and malfunction of stem cells
EMBO Reports 13 (1): 9-11 (2011-12-23)
Willecke R; Heuberger J; Grossmann K; Michos O; Schmidt-Ott K; Walentin K; Costantini F; Birchmeier W
The tyrosine phosphatase Shp2 acts downstream of GDNF/Ret in branching morphogenesis of the developing mouse kidney
Developmental Biology 360 (2): 310-307 (2011-12-15)
2010
Wend P; Holland JD; Ziebold U; Birchmeier W
Wnt signaling in stem and cancer stem cells
Seminars in Cell & Developmental Biology 21 (8): 855-863 (2010-10)
Heuberger J; Birchmeier W
Interplay of cadherin-mediated cell adhesion and canonical wnt signaling
Cold Spring Harbor Perspectives in Biology 2 (2): a002915 (2010-02)
Chirasani SR; Sternjak A; Wend P; Momma S; Campos B; Herrmann IM; Graf D; Mitsiadis T; Herold-Mende C; Besser D; Synowitz M; Kettenmann H; Glass R
Bone morphogenetic protein-7 release from endogenous neural precursor cells suppresses the tumourigenicity of stem-like glioblastoma cells
Brain 133 (Pt 7): 1961-1972 (2010-07)
Talamillo A; Delgado I; Nakamura T; de-Vega S; Yoshitomi Y; Unda F; Birchmeier W; Yamada Y; Ros MA
Role of Epiprofin, a zinc-finger transcription factor, in limb development
Developmental Biology 337 (2): 363-374 (2010-01-15)
Grossmann KS; Rosario M; Birchmeier C; Birchmeier W
The tyrosine phosphatase Shp2 in development and cancer
Advances in Cancer Research 106: 53-89 (2010)
Juerchott K; Kuban RJ; Krech T; Bluethgen N; Stein U; Walther W; Friese C; Kielbasa SM; Ungethuem U; Lund P; Knoesel T; Kemmner W; Morkel M; Fritzmann J; Schlag PM; Birchmeier W; Krueger T; Sperling S; Sers C; Royer HD; Herzel H; Schaefer R
Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells
PLoS Genetics 6 (12): e1001231 (2010-12-02)
Haurie V; Durrieu-Gaillard S; Dumay-Odelot H; Da Silva D; Rey C; Prochazkova M; Roeder RG; Besser D; Teichmann M
Two isoforms of human RNA polymerase III with specific functions in cell growth and transformation
Proceedings of the National Academy of Sciences of the United States of America 107 (9): 4176-4181 (2010-03-02)
2009
Stein U; Walther W; Arlt F; Schwabe H; Smith J; Fichtner I; Birchmeier W; Schlag PM
MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis
Nature Medicine 15 (1): 59-67 (2009-01)
Klaus A; Birchmeier W
Developmental signaling in myocardial progenitor cells: A comprehensive view of Bmp- and Wnt/beta-catenin signaling
Pediatric Cardiology 30 (5): 609-616 (2009-07)
Suzuki K; Yamaguchi Y; Villacorte M; Mihara K; Akiyama M; Shimizu H; Taketo MM; Nakagata N; Tsukiyama T; Yamaguchi TP; Birchmeier W; Kato S; Yamada G
Embryonic hair follicle fate change by augmented {beta}-catenin through Shh and Bmp signaling
Development 136 (3): 367-372 (2009-02)
Zhang Y; Tomann P; Andl T; Gallant NM; Huelsken J; Jerchow B; Birchmeier W; Paus R; Piccolo S; Mikkola ML; Morrisey EE; Overbeek PA; Scheidereit C; Millar SE; Schmidt-Ullrich R
Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction
Developmental Cell 17 (1): 49-61 (2009-07)
Grossmann KS; Wende H; Paul FE; Cheret C; Garratt AN; Zurborg S; Feinberg K; Besser D; Schulz H; Peles E; Selbach M; Birchmeier W; Birchmeier C
The tyrosine phosphatase Shp2 (PTPN11) directs neuregulin-1/ErbB signaling throughout schwann cell development
Proceedings of the National Academy of Sciences of the United States of America 106 (39): 16704-16709 (2009-09-29)
Fritzmann J; Morkel M; Besser D; Budczies J; Kosel F; Brembeck FH; Stein U; Fichtner I; Schlag PM; Birchmeier W
A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential
Gastroenterology 137 (11): 165-175 (2009-07)
Wijk NV; Witte F; Feike AC; Schambony A; Birchmeier W; Mundlos S; Stricker S
The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling
Biochemical and Biophysical Research Communications 390 (2): 211-216 (2009-12-11)
2008
Kaufman WL; Kocman I; Agrawal V; Rahn HP; Besser D; Gossen M
Homogeneity and persistence of transgene expression by omitting antibiotic selection in cell line isolation
Nucleic Acids Research 36 (17): e111 (2008-10)
Naerhi K; Jaervinen E; Birchmeier W; Taketo MM; Mikkola ML; Thesleff I
Sustained epithelial beta-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation
Development 135 (6): 1019-1028 (2008-03)
Grigoryan T; Wend P; Klaus A; Birchmeier W
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice
Genes & Development 22 (17): 2308-2341 (2008-09-01)
Hellmuth K; Grosskopf S; Lum CT; Wuertele M; Roeder N; von Kries JP; Rosario M; Rademann J; Birchmeier W
Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking
Proceedings of the National Academy of Sciences of the United States of America 105 (20): 7275-7280 (2008-05-20)
Diecke S; Quiroga-Negreira A; Redmer T; Besser D
FGF2 signaling in mouse embryonic fibroblasts is crucial for self-renewal of embryonic stem cells
Cells Tissues Organs 188 (1-2): 52-61 (2008)
Klaus A; Birchmeier W
Wnt signalling and its impact on development and cancer
Nature Reviews Cancer 8 (5): 387-398 (2008-05)
Malanchi I; Peinado H; Kassen D; Hussenet T; Metzger D; Chambon P; Huber M; Hohl D; Cano A; Birchmeier W; Huelsken J
Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling
Nature 452 (7187): 650-653 (2008-04-03)
Jeannet G; Scheller M; Scarpellino L; Duboux S; Gardiol N; Back J; Kuttler F; Malanchi I; Birchmeier W; Leutz A; Huelsken J; Held W
Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin
Blood 111 (1): 142-149 (2008-01-01)
2007
Schaeper U; Vogel R; Chmielowiec J; Huelsken J; Rosario M; Birchmeier W
Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo
Proceedings of the National Academy of Sciences of the United States of America 104 (39): 15376-15381 (2007-09-25)
Klaus A; Saga Y; Taketo MM; Tzahor E; Birchmeier W
Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis
Proceedings of the National Academy of Sciences of the United States of America 104 (47): 18531-18536 (2007-11-20)
Rosario M; Franke R; Bednarski C; Birchmeier W
The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42
Journal of Cell Biology 178 (3): 503-516 (2007-07-30)
Baurand A; Zelarayan L; Betney R; Gehrke C; Dunger S; Noack C; Busjahn A; Huelsken J; Taketo MM; Birchmeier W; Dietz R; Bergmann MW
Beta-catenin downregulation is required for adaptive cardiac remodeling
Circulation Research 100 (9): 1353-1362 (2007-05-11)
Zechner D; Mueller T; Wende H; Walther I; Taketo MM; Crenshaw EB; Treier M; Birchmeier W; Birchmeier C
Bmp and Wnt/beta-catenin signals control expression of the transcription factor Olig3 and the specification of spinal cord neurons
Developmental Biology 303 (1): 181-190 (2007-03-01)
Koch A; Hrychyk A; Hartmann W; Waha A; Mikeska T; Waha A; Schuller U; Sorensen N; Berthold F; Goodyer CG; Wiestler OD; Birchmeier W; Behrens J; Pietsch T
Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas
International Journal of Cancer 121 (2): 284-291 (2007-07-15)
Chmielowiec J; Borowiak M; Morkel M; Stradal T; Munz B; Werner S; Wehland J; Birchmeier C; Birchmeier W
c-Met is essential for wound healing in the skin
Journal of Cell Biology 177 (1): 151-162 (2007-04-09)
Faraldo MM; Teuliere J; Deugnier MA; Birchmeier W; Huelsken J; Thiery JP; Cano A; Glukhova MA
Beta-catenin regulates P-cadherin expression in mammary basal epithelial cells
FEBS Letters 581 (5): 831-836 (2007-03-06)
Hosking CR; Ulloa F; Hogan C; Ferber E; Figueroa A; Gevaert K; Birchmeier W; Briscoe J; Fujita Y
The transcriptional repressor Glis2 is a novel binding partner for p120 catenin
Molecular Biology of the Cell 18 (5): 1918-1927 (2007-05)
2006
Stein U; Arlt F; Walther W; Smith J; Waldman T; Harris ED; Mertins SD; Heizmann CW; Allard D; Birchmeier W; Schlag PM; Shoemaker RH
The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor (TCF) signaling in colon cancer
Gastroenterology 131 (5): 1486-1500 (2006-11)
Scheller M; Huelsken J; Rosenbauer F; Taketo MM; Birchmeier W; Tenen DG; Leutz A
Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation
Nature Immunology 7 (10): 1037-1047 (2006-10)
Hill TP; Taketo MM; Birchmeier W; Hartmann C
Multiple roles of mesenchymal beta-catenin during murine limb patterning
Development 133: 1219-1229 (2006-02-22)
Schaeper U; Grossmann KS
Tyrosine kinases
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2 : 1951-1959 (2006-07-05)
Soshnikova N; Birchmeier W
Limb development
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 1 : 976-981 (2006-07-05)
MacRae CA; Birchmeier W; Thierfelder L
Arrhythmogenic right ventricular cardiomyopathy: moving toward mechanism
Journal of Clinical Investigation 116 (7): 1825-1828 (2006-07)
Hadjihannas MV; Brueckner M; Jerchow B; Birchmeier W; Dietmaier W; Behrens J
Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer
Proceedings of the National Academy of Sciences of the United States of America 103: 10747-10752 (2006-07-11)
Jaervinen E; Salazar-Ciudad I; Birchmeier W; Taketo MM; Jernvall J; Thesleff I
Continuous tooth generation in mouse is induced by activated epithelial Wnt/{beta}-catenin signaling
Proceedings of the National Academy of Sciences of the United States of America 103: 18627-18632 (2006-12-05)
Moeller H; Jenny A; Schaeffer HJ; Schwarz-Romond T; Mlodzik M; Hammerschmidt M; Birchmeier W
Diversin regulates heart formation and gastrulation movements in development
Proceedings of the National Academy of Sciences of the United States of America 103 (43): 15900-15905 (2006-10-24)
Brembeck FH; Rosario M; Birchmeier W
Balancing cell adhesion and Wnt signaling, the key role of beta-catenin
Current Opinion in Genetics & Development 16 (1): 51-59 (2006-02)
2005
Pullikuth A; McKinnon E; Schaeffer HJ; Catling AD
The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals
Molecular and Cellular Biology 25: 5119-5133 (2005-06-01)
Hirrlinger J; Moeller H; Kirchhoff F; Dringen R
Expression of multidrug resistance proteins (Mrps) in astrocytes of the mouse brain: a single cell rt-PCR study
Neurochemical Research 30: 1237-1244 (2005-10-01)
Stelzl U; Worm U; Lalowski M; Haenig C; Brembeck FH; Goehler H; Stroedicke M; Zenkner M; Schoenherr A; Koeppen S; Timm J; Mintzlaff S; Abraham C; Bock N; Kietzmann S; Goedde A; Toksoez E; Droege A; Krobitsch S; Korn B; Birchmeier W; Lehrach H; Wanker EE
A human protein-protein interaction network: a resource for annotating the proteome
Cell 122 (6): 957-968 (2005-09-23)
Shu W; Guttentag S; Wang Z; Andl T; Ballard P; Lu MM; Piccolo S; Birchmeier W; Whitsett JA; Millar SE; Morrisey EE
Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung
Developmental Biology 283: 226-239 (2005-01-01)
Hill TP; Spaeter D; Taketo MM; Birchmeier W; Hartmann C
Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes
Developmental Cell 8 (5): 727-738 (2005-05-01)
Sharma C; Vomastek T; Tarcsafalvi A; Catling AD; Schaeffer HJ; Eblen ST; Weber MJ
MEK Partner 1 (MP1): Regulation of oligomerization in MAP kinase signaling
Journal of Cellular Biochemistry 94: 708-719 (2005-01-01)
Yu HM; Jerchow B; Sheu TJ; Liu B; Costantini F; Puzas JE; Birchmeier W; Hsu W
The role of Axin2 in calvarial morphogenesis and craniosynostosis
Development 132: 1995-2005 (2005-01-01)
Schaeper U; Birchmeier W
HGF/SF c-Met signaling in the epithelial-mesenchymal transition and migration of muscle progenitor cells
Cell Migration in Development and Disease : 191-204 (2005-01-01)
Birchmeier W
Cell adhesion and signal transduction in cancer
EMBO Reports 6: 413-417 (2005-01-01)
2004
Hogan C; Serpente N; Cogram P; Hosking CR; Bialucha CU; Feller SM; Braga VMM; Birchmeier W; Fujita Y
Rap1 regulates the formation of E-cadherin-based cell-cell contacts
Molecular and Cellular Biology 24: 6690-6700 (2004-01-01)
Zechner D; Soshnikova N; Birchmeier W
Deciphering the function of signaling pathways by tissue specific gene modification in mice
Zellbiologie Aktuell 30 (1): 6-8 (2004-01)
Teuliere J; Faraldo MM; Shtutman M; Birchmeier W; Huelsken J; Thiery JP; Glukhova MA
beta-catenin-dependent and -independent effects of deltaN-plakoglobin on epidermal growth and differentiation
Molecular and Cellular Biology 24: 8649-8661 (2004-10-01)
van den Akker E; van Dijk T; Parren-van Amelsvoort M; Grossmann KS; Schaeper U; Toney-Earley K; Waltz SE; Loewenberg B; von Lindern M
Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors
Blood 103: 4457-4465 (2004-01-01)
Grossmann KS; Grund C; Huelsken J; Behrend M; Erdmann B; Franke WW; Birchmeier W
Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation
Journal of Cell Biology 167 (1): 149-160 (2004-10-11)
Brembeck FH; Schwarz-Romond T; Bakkers J; Wilhelm S; Hammerschmidt M; Birchmeier W
Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions
Genes & Development 18: 2225-2230 (2004-09-15)
Schuetz G; Rosario M; Grimm J; Boeckers TM; Gundelfinger ED; Birchmeier W
The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells
Journal of Cell Biology 167 (5): 945-952 (2004-12-06)
Besser D
Expression of nodal, lefty-A, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3
Journal of Biological Chemistry 279: 45076-45084 (2004-01-01)
Gerull B; Heuser A; Wichter T; Paul M; Basson CT; McDermott DA; Lerman BB; Markowitz SM; Ellinor PT; MacRae CA; Peters S; Grossmann KS; Drenckhahn J; Michely B; Sasse-Klaassen S; Birchmeier W; Dietz R; Breithardt G; Schulze-Bahr E; Thierfelder L
Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy [Corrigendum in: Nat Genet. 2005 Jan;37(1):106]
Nature Genetics 36: 1162-1164 (2004-10-17)
Rosario M; Birchmeier W
Making tubes: Step by step
Developmental Cell 7: 3-5 (2004-07-01)
Lamothe B; Yamada M; Schaeper U; Birchmeier W; Lax I; Schlessinger J
The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathway
Molecular and Cellular Biology 24: 5657-5666 (2004-01-01)
Koch A; Weber N; Waha A; Hartmann W; Denkhaus D; Behrens J; Birchmeier W; von Schweinitz D; Pietsch T
Mutations and elevated transcriptional activity of conductin (AXIN2) in hepatoblastomas
Journal of Pathology 204: 546-554 (2004-01-01)
2003
Zechner D; Fujita Y; Huelsken J; Mueller T; Walther I; Taketo MM; Crenshaw EB; Birchmeier W; Birchmeier C
beta-catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system
Developmental Biology 258: 406-418 (2003-01-01)
Churin Y; Al Ghoul L; Kepp O; Meyer TE; Birchmeier W; Naumann M
Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response
Journal of Cell Biology 161 (2): 249-255 (2003-04-28)
Birchmeier C; Birchmeier W; Gherardi E; Vande Woude GF
Met, metastasis, motility and more
Nature Reviews Molecular Cell Biology 4 (12): 915-925 (2003-12)
Morkel M; Huelsken J; Wakamiya M; Ding JX; van de Wetering M; Clevers H; Taketo MM; Behringer RR; Shen MM; Birchmeier W
beta-Catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation
Development 130: 6283-6294 (2003-01-01)
Bamji SX; Shimazu K; Kimes N; Huelsken J; Birchmeier W; Lu B; Reichardt LF
Role of beta-catenin in synaptic vesicle localization and presynaptic assembly
Neuron 40: 719-731 (2003-01-01)
Xu YY; Banerjee D; Huelsken J; Birchmeier W; Sen JM
Deletion of beta-catenin impairs T cell development
Nature Immunology 4: 1177-1182 (2003-01-01)
Soshnikova N; Zechner D; Huelsken J; Mishina Y; Behringer RR; Taketo MM; Crenshaw EB; Birchmeier W
Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb
Genes & Development 17: 1963-1968 (2003-01-01)
Rosario M; Birchmeier W
How to make tubes: signaling by the Met receptor tyrosine kinase
Trends in Cell Biology 13: 328-335 (2003-01-01)
Mucenski ML; Wert SE; Nation JM; Loudy DE; Huelsken J; Birchmeier W; Morrisey EE; Whitsett JA
beta-catenin is required for specification of proximal/distal cell fate during lung morphogenesis
Journal of Biological Chemistry 278: 40231-40238 (2003-01-01)
2002
Lustig B; Jerchow B; Sachs M; Weiler S; Pietsch T; Karsten U; van de Wetering M; Clevers H; Schlag PM; Birchmeier W; Behrens J
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors
Molecular and Cellular Biology 22 (4): 1184-1193 (2002-02-01)
Fujita Y; Krause G; Scheffner M; Zechner D; Leddy HEM; Behrens J; Sommer T; Birchmeier W
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex
Nature Cell Biology 4 (3): 222-231 (2002-03-01)
Wong MH; Huelsken J; Birchmeier W; Gordon JI
Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkuehn is perturbed by stimulation of Lef-1/beta-catenin signaling
Journal of Biological Chemistry 277 (18): 15843-15850 (2002-01-01)
Niemann C; Owens DM; Huelsken J; Birchmeier W; Watt FM
Expression of deltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours
Development 129: 95-109 (2002-01-01)
Kurz SM; Diebold SS; Hieronymus T; Gust TC; Bartunek P; Sachs M; Birchmeier W; Zenke M
The impact of c-met/scatter factor receptor on dendritic cell migration
European Journal of Immunology 32: 1832-1838 (2002-01-01)
Schwarz-Romond T; Asbrand C; Bakkers J; Kuhl M; Schaeffer HJ; Huelsken J; Behrens J; Hammerschmidt M; Birchmeier W
The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling
Genes & Development 16: 2073-2084 (2002-01-01)
2001
Schmidt-Ullrich R; Aebischer T; Huelsken J; Birchmeier W; Klemm U; Scheidereit C
Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices
Development 128: 3843-3853 (2001-01-01)
Grimm J; Sachs M; Britsch S; Di Cesare S; Schwarz-Romond T; Birchmeier W
Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation
Journal of Cell Biology 154 (2): 345-354 (2001-07-23)
Lewitzky M; Kardinal C; Gehring NH; Schmidt EK; Konkol B; Eulitz M; Birchmeier W; Schaeper U; Feller SM
The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif
Oncogene 20: 1052-1062 (2001-01-01)
Huelsken J; Vogel R; Erdmann B; Cotsarelis G; Birchmeier W
beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin
Cell 105 (4): 533-545 (2001-05-18)
Huelsken J; Birchmeier W
New aspects of Wnt signaling pathways in higher vertebrates
Current Opinion in Genetics & Development 11 (5): 547-553 (2001-10-01)
Keilhack H; Mueller M; Boehmer SA; Frank C; Weidner KM; Birchmeier W; Ligensa T; Berndt A; Kosmehl H; Gunther B; Mueller T; Birchmeier C; Boehmer FD
Negative regulation of Ros receptor tyrosine kinase signaling: An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1
Journal of Cell Biology 152 (2): 325-334 (2001-01-22)
Dahmen RP; Koch A; Denkhaus D; Tonn JC; Soerensen N; Berthold F; Behrens J; Birchmeier W; Wiestler OD; Pietsch T
Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas
Cancer Research 61: 7039-7043 (2001-01-01)
2000
Sakkab D; Lewitzky M; Posern G; Schaeper U; Sachs M; Birchmeier W; Feller SM
Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL
Journal of Biological Chemistry 275: 10772-10778 (2000-04-14)
Schaeper U; Gehring NH; Fuchs KP; Sachs M; Kempkes B; Birchmeier W
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
Journal of Cell Biology 149 (7): 1419-1432 (2000-06-26)
von Kries JP; Winbeck G; Asbrand C; Schwarz-Romond T; Sochnikova N; Dell'Oro A; Behrens J; Birchmeier W
Hot spots in beta-catenin for interactions with LEF-1, conductin and APC
Nature Structural Biology 7: 800-807 (2000-01-01)
Huelsken J; Vogel R; Brinkmann V; Erdmann B; Birchmeier C; Birchmeier W
Requirement for beta-catenin in anterior-posterior axis formation in mice
Journal of Cell Biology 148 (3): 567-578 (2000-02-07)
Sachs M; Brohmann H; Zechner D; Mueller T; Huelsken J; Walther I; Schaeper U; Birchmeier C; Birchmeier W
Essential role of Gab1 for signaling by the c-Met receptor in vivo
Journal of Cell Biology 150 (6): 1375-1384 (2000-09-18)
Behrens J
Control of beta-catenin signaling in tumor development
Annals of the New York Academy of Sciences 910: 21-35 (2000-06)
Smits R; Ruiz P; Diaz-Cano S; Luz A; Jagmohan-Changur S; Breukel C; Birchmeier C; Birchmeier W; Fodde R
E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice
Gastroenterology 119 (4): 1045-1053 (2000-10-01)
Honeck H; Gross V; Erdmann B; Kaergel E; Neunaber R; Milia AF; Schneider W; Luft FC; Schunck WH
Cytochrome P450-dependent renal arachidonic acid metabolism in desoxycorticosterone acetate-salt hypertensive mice
Hypertension 36: 610-616 (2000-10-01)
Niemann C; Brinkmann V; Birchmeier W
Hepatocyte growth factor and neuregulin in mammary gland cell morphogenesis
Advances in Experimental Medicine and Biology 480: 9-18 (2000-01-01)
1999
Ghadimi BM; Behrens J; Hoffmann I; Haensch W; Birchmeier W; Schlag PM
Immunohistological analysis of E-cadherin, alpha-, beta- and gamma-catenin expression in colorectal cancer: Implications for cell adhesion and signaling
European Journal of Cancer 35 (1): 60-65 (1999-01)
Handschuh G; Candidus S; Luber B; Reich U; Schott C; Oswald S; Becke H; Hutzler P; Birchmeier W; Hoefler H; Becker KF
Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility
Oncogene 18: 4301-4312 (1999-07-29)
Isac CM; Ruiz P; Pfitzmaier B; Haase H; Birchmeier W; Morano I
Plakoglobin is essential for myocardial compliance but dispensable for myofibril insertion into adherens junctions
Journal of Cellular Biochemistry 72 (1): 8-15 (1999-01-01)
Birchmeier W; Birchmeier C
Epithelial Morphogenesis in Development and Disease
: (1999-01-01)
Lichtner RB; Parczyk K; Birchmeier W; Schneider MR
Differential cross-talk of estrogen and growth factor receptors in two human mammary tumor cell lines
Journal of Steroid Biochemistry and Molecular Biology 71: 181-189 (1999-12-31)
Birchmeier W
Introduction
Guidebook to the Extracellular Matrix, Anchor, and Adhesion Proteins : 121-125 (1999-01-01)
Birchmeier W; Birchmeier C; Brinkmann V; Niemann C
10. Tyrosine kinase receptors as driving forces for growth, motility and differentiation of epithelial cells
Epithelial Morphogenesis in Development and Disease : 217-231 (1999-01-01)
Birchmeier W
Hot papers in cell biology - J. Behrens, J.P. von Kries, M. Kuehl, L. Bruhn, D. Wedlich, R. Grosschedl, W. Birchmeier: "Functional interaction of beta-catenin with the transcription factor LEF-1" - Comments by Walter Birchmeier
Scientist 13(8): 15 (1999-04-12)
1998
Schwechheimer K; Zhou L; Birchmeier W
E-Cadherin in human brain tumours: loss of immunoreactivity in malignant meningiomas
Virchows Archiv 432: 163-167 (1998-01-01)
Lin S; Rusciano D; Lorenzoni P; Hartmann G; Birchmeier W; Giordano S; Comoglio P; Burger MM
C-met activation is necessary but not sufficient for liver colonization by B16 murine melanoma cells
Clinical and Experimental Metastasis 16: 253-265 (1998-01-01)
Meiners S; Brinkmann V; Naundorf H; Birchmeier W
Role of morphogenetic factors in metastasis of mammary carcinoma cells
Oncogene 16: 9-20 (1998-01-01)
Ruiz P; Birchmeier W
The plakoglobin knock-out mouse: A paradigm for the molecular analysis of cardiac cell junction formation
Trends in Cardiovascular Medicine 8 (3): 97-101 (1998-04)
Behrens J; Jerchow BA; Wuertele M; Grimm J; Asbrand C; Wirtz R; Kuehl M; Wedlich D; Birchmeier W
Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
Science 280 (5363): 596-599 (1998-04-24)
Hartmann G; Prospero T; Brinkmann V; Ozcelik O; Winter G; Hepple J; Batley S; Bladt F; Sachs M; Birchmeier C; Birchmeier W; Gherardi E
Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo
Current Biology 8 (3): 125-134 (1998-01-29)
Sommer W; Cui X; Erdmann B; Wiklund L; Bricca G; Heilig M; Fuxe K
The spread and uptake pattern of intracerebrally administered oligonucleotides in nerve and glial cell populations of the rat brain
Antisense and Nucleic Acid Drug Development 8: 75-85 (1998-01-01)
Niemann C; Brinkmann V; Spitzer E; Hartmann G; Sachs M; Naundorf H; Birchmeier W
Reconstitution of mammary gland development in vitro: Requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesis
Journal of Cell Biology 143 (2): 533-545 (1998-10-19)
1997
Schoenborn I; Zschiesche W; Behrens J; Herrenknecht K; Birchmeier W
Expression of E-cadherin/catenin complexes in breast cancer: correlation with favourable prognostic factors and survival
International Journal of Oncology 11: 1327-1334 (1997-01-01)
Faraldo MLM; Rodrigo I; Behrens J; Birchmeier W; Cano A
Analysis of the E-cadherin and P-cadherin promoters in murine keratinocyte cell lines from different stages of mouse skin carcinogenesis
Molecular Carcinogenesis 20: 33-47 (1997-01-01)
Schaper F; Siewert E; Gomez-Lechon MJ; Gatsios P; Sachs M; Birchmeier W; Heinrich PC; Castell J
Hepatocyte growth factor/ scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes
FEBS Letters 405: 99-103 (1997-01-01)
Zschiesche W; Schoenborn I; Behrens J; Herrenknecht K; Hartveit F; Lilleng P; Birchmeier W
Expression of E-cadherin and catenins in invasive mammary carcinomas
Anticancer Research 17: 561-567 (1997-01-01)
Birchmeier W; Brinkmann V; Niemann C; Meiners S; Dicesare S; Naundorf H; Sachs M
Role of HGF/SF and c-Met in morphogenesis and metastasis of epithelial cells
Ciba Foundation Symposia 212: 230-240 (1997-01-01)
Drab M; Haller H; Bychkov R; Erdmann B; Lindschau C; Haase H; Morano I; Luft FC; Wobus AM
From totipotent embryonic stem cells to spontaneously contracting smooth muscle cells: a retinoic acid and db-cAMP in vitro differentiation model
FASEB Journal 11 (11): 905-915 (1997-09)
1996
Guenthert U; Birchmeier W
Attempts to Understand Metastasis Formation I - III. Part 2: Regulatory Factors
: (1996-01-01)
Hennig G; Loewrick O; Birchmeier W; Behrens J
Mechanisms identified in the transcriptional control of epithelial gene expression
Journal of Biological Chemistry 271: 595-602 (1996-01-01)
Sachs M; Weidner KM; Brinkmann V; Walther I; Obermeier A; Ullrich A; Birchmeier W
Motogenic and morphogenic activity of epithelial receptor tyrosine kinases
Journal of Cell Biology 133 (5): 1095-1107 (1996-06-03)
Weidner KM; Dicesare S; Sachs M; Brinkmann V; Behrens J; Birchmeier W
Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis
Nature 384 (6605): 173-176 (1996-11-14)
Haller H; Lindschau C; Erdmann B; Quass P; Luft FC
Effects of intracellular angiotensin II in vascular smooth muscle cells
Circulation Research 79: 765-772 (1996-10-01)
Guenthert U; Birchmeier W
Attempts to Understand Metastasis Formation I - III. Part 1: Metastasis-Related Molecules
: (1996-01-01)
Guenthert U; Schlag PM; Birchmeier W
Attempts to Understand Metastasis Formation I - III. Part 3: Therapeutic Approaches to Metastasis Treatment
: (1996-01-01)
Gabbert HE; Mueller W; Schneiders A; Meier S; Moll R; Birchmeier W; Hommel G
Prognostic value of a cadherin expression in 413 gastric carcinomas
International Journal of Cancer 69: 184-189 (1996-01-01)
Ruiz P; Brinkmann V; Ledermann B; Behrend M; Grund C; Thalhammer C; Vogel F; Birchmeier C; Guenthert U; Franke WW; Birchmeier W
Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart
Journal of Cell Biology 135 (1): 215-225 (1996-10)
Erdmann B; Gerst H; Lippoldt A; Buelow H; Ganten D; Fuxe K; Bernhardt R
Expression of cytochrome P45011B1 mRNA in the brain of normal and hypertensive transgenic rats
Brain Research 733: 73-82 (1996-01-01)
Behrens J; von Kries JP; Kuehl M; Bruhn L; Wedlich D; Grosschedl R; Birchmeier W
Functional interaction of beta-catenin with the transcription factor LEF-1
Nature 382 (6592): 638-642 (1996-08-15)
Birchmeier W; Behrens J; Weidner KM; Huelsken J; Birchmeier C
Epithelial differentiation and the control of metastasis in carcinomas
Attempts to Understand Metastasis Formation II : 117-135 (1996-01-01)
Birchmeier C; Birchmeier W; Brand-Saberi B
Epithelial-mesenchymal transitions in cancer progression
Acta Anatomica 156: 217-226 (1996-01-01)
Erdmann B; Fuxe K; Ganten D
Subcellular localization of angiotensin II immunoreactivity in the rat cerebellar cortex
Hypertension 28: 818-824 (1996-01-01)
1995
Spitzer E; Zschiesche W; Binas B; Grosse R; Erdmann B
EGF and TGFalpha modulate structural and functional differentiation of the mammary gland from pregnant mice in vitro: Possible role of the arachidomic pathway
Journal of Cellular Biochemistry 57: 495-508 (1995-01-01)
Schlag PM; Huenerbein M; Hohenberger P
Surgical and multimodal approaches to liver metastases
Attempts to Understand Metastasis Formation : 241-256 (1995-01-01)
Erdmann B; Gerst H; Buelow H; Lenz D; Baehr V; Bernhardt R
Zone-specific localization of cytochrome P45011B1 in human adrenal tissue by PCR-derived riboprobes
Histochemistry and Cell Biology 104: 301-307 (1995-01-01)
Birchmeier W
E-cadherin as a tumor (invasion) suppressor gene
BioEssays 17: 97-99 (1995-01-01)
Takeda H; Nagafuchi A; Yonemura S; Tsukita S; Behrens J; Birchmeier W; Tsukita S
V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta-catenin is not required for the shift
Journal of Cell Biology 131 (6 Pt. 2): 1839-1847 (1995-12)
Plaschke-Schluetter A; Behrens J; Gherardi E; Birchmeier W
Characterization of the scatter factor/hepatocyte growth factor gene promoter - positive and negative regulatory elements direct gene expression to mesenchymal cells
Journal of Biological Chemistry 270: 830-836 (1995-01-01)
Erdmann B; Denner K; Gerst H; Lenz D; Bernhardt R
Human adrenal CYP11B1: localization by in situ-hybridization and functional expression in cell cultures
Endocrine Research 21: 425-435 (1995-01-01)
Brinkmann V; Foroutan H; Sachs M; Weidner KM; Birchmeier W
Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells
Journal of Cell Biology 131 (6 Pt. 1): 1573-1586 (1995-12)
Birchmeier W; Huelsken J; Behrens J
Adherens junction proteins in tumour progression
Cancer Surveys 24: 129-140 (1995-01-01)
Birchmeier W; Huelsken J; Behrens J
E-cadherin as an invasion suppressor
Ciba Foundation Symposia 189: 124-136, discussion 136-41, 174-6 (1995-01-01)
Weidner KM; Sachs M; Riethmacher D; Birchmeier W
Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells
Proceedings of the National Academy of Sciences of the United States of America 92: 2597-2601 (1995-01-01)
Birchmeier W; Birchmeier C
Epithelial-mesenchymal transitions in development and tumor progression
Epithelial-Mesenchymal Interactions in Cancer : 1-16 (1995-01-01)
Yang Y; Spitzer E; Meyer D; Sachs M; Niemann C; Hartmann G; Weidner KM; Birchmeier C; Birchmeier W
Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland
Journal of Cell Biology 131 (1): 215-226 (1995-10)
Hennig G; Behrens J; Truss M; Frisch S; Reichmann E; Birchmeier W
Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo
Oncogene 11: 475-484 (1995-01-01)
Scheumman GFW; Hoangvu C; Cetin Y; Gimm O; Behrens J; von Wasielewski R; Georgii A; Birchmeier W; von zur Muehlen A; Dralle H; Brabant G
Clinical significance of e-cadherin as a prognostic marker in thyroid carcinomas
Journal of Clinical Endocrinology and Metabolism 80 (7): 2168-2172 (1995-01-01)
1994
Birchmeier W
Molecular aspects of the loss of cell adhesion and gain of invasiveness in carcinomas
Proceedings of the international symposium of the Princess Takamatsu Cancer Research Fund : 214-232 (1994-01-01)
Kraus C; Liehr T; Huelsken J; Behrens J; Birchmeier W; Grzeschik KH; Ballhausen WG
Localization of the human beta-catenin gene (CTNNB1) to 3p21: A region implicated in tumor development
Genomics 23: 272-274 (1994-01-01)
Huelsken J; Behrens J; Birchmeier W
Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection
Current Opinion in Cell Biology 6: 711-716 (1994-01-01)
Behrens J; Birchmeier W
Cell-cell adhesion in invasion and metastasis of carcinomas
Mammary Tumorigenesis and Malignant Progression : 251-266 (1994-01-01)
Breter H; Erdmann B
Localization of mammary-derived growth inhibitor in capillary endothelial cells of the bovine mammary gland
Cell and Tissue Research 277: 457-464 (1994-01-01)
Huelsken J; Birchmeier W; Behrens J
E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
Journal of Cell Biology 127 (6 Pt. 2): 2061-2069 (1994-12)
Birchmeier W; Behrens J
Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness
Biochimica et Biophysica Acta 1198 (1): 11-26 (1994-05-27)
Oda T; Kanai Y; Oyama T; Yoshiura K; Shimoyama Y; Birchmeier W; Sugimura T; Hirohashi S
E-cadherin gene mutations in human gastric carcinoma cell lines
Proceedings of the National Academy of Sciences of the United States of America 91 (5): 1858-1862 (1994-03-01)
Hartmann G; Weidner KM; Schwarz H; Birchmeier W
The motility signal of scatter factor /hepatocyte growth factor mediated through the receptor tyrosine kinase Met requires intracellular action of Ras
Journal of Biological Chemistry 269: 21936-21939 (1994-01-01)
Birchmeier W; Birchmeier C
Mesenchymal-epithelial transitions
BioEssays 16: 305-307 (1994-01-01)
Boehm M; Totzeck B; Birchmeier W; Wieland I
Differences of E-cadherin expression levels and patterns in primary and metastatic human lung cancer
Clinical and Experimental Metastasis 12: 55-62 (1994-01-01)
Erdmann B; Henning M; Uhlmann H; Beckert V; Grunau C; Bernhardt R
Immunocytochemical localization of heterologously expressed adrenodoxin and its electron acceptor cytochrome P45011B1 in Escherichia coli
European Journal of Cell Biology 65: 220-228 (1994-01-01)
Otto T; Birchmeier W; Schmidt U; Hinke A; Schipper J; Ruebben H; Raz A
Inverse relation of E-cadherin and autocrine motility factor receptor expression as a prognostic factor in patients with bladder carcinomas
Cancer Research 54 (12): 3120-3123 (1994-06-15)
1993
Birchmeier W; Weidner KM; Huelsken J; Behrens J
Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas
Seminars in Cancer Biology 4 (4): 231-239 (1993-08-01)
Birchmeier C; Birchmeier W
Molecular aspects of mesenchymal-epithelial interactions
Annual Review of Cell Biology 9: 511-540 (1993)
Erdmann B; Breter H
Irregular distribution of mammary-derived growth inhibitor in the bovine mammary epithelium
Cell and Tissue Research 272: 383-389 (1993-01-01)
Weidner KM; Sachs M; Birchmeier W
The Met receptor tyrosine kinase transduces motility, proliferation, andmorphogenic signals of scatter factor/ hepatocyte growth factor in epithelial cells
Journal of Cell Biology 121 (1): 145-154 (1993-04)
Moll R; Mitze M; Frixen UH; Birchmeier W
Differential loss of E-Cadherin expression in infiltrating ductal and lobular breast carcinomas
American Journal of Pathology 143 (6): 1731-1742 (1993-12-01)
Slagle BL; Zhou YZ; Birchmeier W; Scorsone KA
Deletion of the e-Cadherin gene in hepatitis-B virus-positive chinese hepatocellular carcinomas
Hepatology 18 (4): 757-762 (1993-10-01)
Birchmeier W; Weidner KM; Behrens J
Molecular mechanisms leading to loss of differentiation and gain of invasiveness in epithelial cells
Journal of Cell Science Suppl. 17: 159-164 (1993-01-01)
Birchmeier W
Undercoat-constitutive proteins of cell-cell adherens junctions
Japanese Journal of Cancer Research 84: 1332-1333 (1993-01-01)
Breter H; Erdmann B
Suitability of different protein a-gold markers for immunogold- silver staining in paraffin sections
Biotechnic and Histochemistry 68: 206-210 (1993-01-01)
Mayer B; Johnson JP; Leitl F; Jauch KW; Heiss MM; Schildberg FW; Birchmeier W; Funke I
E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration
Cancer Research 53 (7): 1690-1695 (1993-04-01)
Weidner KM; Hartmann G; Sachs M; Birchmeier W
Properties and functions of scatter factor/hepatocyte growth factor and its receptor c-Met
American Journal of Respiratory Cell and Molecular Biology 8: 229-237 (1993-01-01)
Behrens J; Vakaet L; Friis R; Winterhager E; van Roy F; Mareel MM; Birchmeier W
Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/?catenin complex in cells transformed with a temperature-sensitive v-SRC gene
Journal of Cell Biology 120 (3): 757-766 (1993-02)
Weidner KM; Hartmann G; Naldini L; Comoglio PM; Sachs M; Fonatsch C; Rieder H; Birchmeier W
Molecular characteristics of HGF-SF and its role in cell motility and invasion
Hepatocyte Growth Factor (HGF-SF) and the C-Met Receptor : 311-328 (1993-01-01)
1992
Behrens J; Frixen U; Schipper J; Weidner KM; Birchmeier W
Cell adhesion in invasion and metastasis
Seminars in Cell Biology 3: 169-178 (1992-01-01)
Birchmeier W; Weidner KM; Behrens J
Molecular aspects of the invasion of carcinoma cells
Metastasis : Basic Research and its Clinical Application : 95-107 (1992-01-01)
Naldini L; Tamagnone L; Vigna E; Sachs M; Hartmann G; Birchmeier W; Daikuhara Y; Tsubouchi H; Blasi F; Comoglio PM
Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor
EMBO Journal 11 (13): 4825-4833 (1992-12-01)
Hartmann G; Naldini L; Weidner KM; Sachs M; Vigna E; Comoglio PM; Birchmeier W
A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis
Proceedings of the National Academy of Sciences of the United States of America 89: 11574-11578 (1992-01-01)
Binas B; Spitzer E; Zschiesche W; Erdmann B; Kurtz A; Mueller T; Niemann C; Blenau W; Grosse R
Hormonal induction of functional differentiation and mammary-derived growth inhibitor expression in cultured mouse mammary gland explants
In Vitro Cellular & Developmental Biology 28A (9-10): 625-634 (1992-09)