ARTERIOGENESIS: THE BIOLOGICAL BYPASS
The Experimental and Clinical Research Center (ECRC, Director: Prof. Dr. F. Luft), is a collaborate effort of the University Hospital Charité and the Max Delbrück Center for Molecular Medicine (MDC) at the campus Berlin-Buch. Its goal is to translate basic science concepts into novel therapeutic strategies useful in the clinic. Within the context of the ECRC, the clinical and experimental arteriogenesis platform, is offering several PhD positions for 3 years.
Project description:
Arteriogenesis, the formation of collateral artery networks to bypass a vessel occlusion, is physiologically the most relevant vis-à-vis restoration of perfusion to ischemic beds. While the functional significance of this process is beginning to be appreciated, its biology is poorly understood. Our research aims at understanding the molecular mechanisms regulation arteriogenesis and angiogenesis, both during normal development and in ischemic cardiovascular diseases including heart-infarct, and stroke. In particular we focus on the contribution of mechanical factors (blood flow) and neural guidance genes in vascular development. Some keywords characterizing our research: arterio-venous differentiation, tip cells, vessel guidance, hemodynamics, mechanosensing, notch signalling, microRNA. Our experimental models include zebrafish, tadpole, chick embryo, ischemia-arteriogenesis models in mice.
Competencies:
University or master degree in (bio)medical sciences, molecular life sciences, pharmacology, embryology, or cardiovascular research. Experience with state of the art molecular biology techniques. Knowledge of animal models used in cardiovascular research Candidates are expected to demonstrate outstanding academic achievement and excellence in life science.
Choosing for the ECRC means choosing for a scientifically outstanding, innovative and internationally oriented environment in which personal contributions to the work and way of working are encouraged, and in which ample attention is given to personal development.
Send your application to:
Prof. Dr. F. le Noble Priv. Doz. Dr. med. I. Buschmann
Max Delbrueck Center for Molecular Medicine (MDC) Center for Cardiovascular Research (CCR)
AG Angiogenesis and Cardiovascular Research Dept. of Cardiology
Robert-Roessle-Strasse 10 Hessische Strasse 3-4
13125 Berlin, Germany Charite - Berlin
email: lenoble@mdc-berlin.de email: ivo.buschmann@charite.de