Publications
2012
Napp LC; Augustynik M; Paesler F; Krishnasamy K; Woiterski J; Limbourg A; Bauersachs J; Drexler H; Le Noble F; Limbourg FP
Extrinsic notch ligand delta-like 1 regulates tip cell selection and vascular branching morphogenesis
Circulation Research 110 (4): 530-550 (2012-01-26)
2011
Hillmeister P; Gatzke N; Duelsner A; Bader M; Schadock I; Hoefer I; Hamann I; Infante-Duarte C; Jung G; Troidl K; Urban D; Stawowy P; Frentsch M; Li M; Nagorka S; Wang H; Shi Y; Le Noble F; Buschmann I
Arteriogenesis is modulated on bradykinin receptor signaling
Circulation Research 109 (5): 524-533 (2011-08-19)
Klein C; Mikutta J; Krueger J; Scholz K; Brinkmann J; Liu D; Veerkamp J; Siegel D; Abdelilah-Seyfried S; Le Noble F
Neuron navigator 3a regulates liver organogenesis during zebrafish embryogenesis
Development 138 (10): 1935-1945 (2011-05-15)
Krueger J; Liu D; Scholz K; Zimmer A; Shi Y; Klein C; Siekmann A; Schulte-Merker S; Cudmore M; Ahmed A; Le Noble F
Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo
Development 138 (10): 2111-2120 (2011-05)
Liu D; Krueger J; Le Noble F
The role of blood flow and microRNAs in blood vessel development
International Journal of Developmental Biology 55 (4-5): 419-429 (2011)
2010
Pries AR; Hoepfner M; Le Noble F; Dewhirst MW; Secomb TW
The shunt problem: control of functional shunting in normal and tumour vasculature
Nature Reviews Cancer 10 (8): 587-593 (2010-08)
Buschmann I; Pries A; Styp-Rekowska B; Hillmeister P; Loufrani L; Henrion D; Shi Y; Duelsner A; Hoefer I; Gatzke N; Wang H; Lehmann K; Ulm L; Ritter Z; Hauff P; Hlushchuk R; Djonov V; van Veen T; le Noble F
Pulsatile shear and Gja5 modulate arterial identity and remodeling events during flow-driven arteriogenesis
Development 137 (13): 2187-2196 (2010-07)
Fleury V; Al-Kilani A; Boryskina OP; Cornelissen AJM; Nguyen TH; Unbekandt M; Leroy L; Baffet G; Le Noble F; Sire O; Lahaye E; Burgaud V
Introducing the scanning air puff tonometer for biological studies
Physical Review E 81 (2): 021920 (2010-02)
Crispi F; Bijnens B; Figueras F; Bartrons J; Eixarch E; Le Noble F; Ahmed A; Gratacos E
Fetal growth restriction results in remodeled and less efficient hearts in children
Circulation 121 (22): 2427-2436 (2010-06-08)
2009
Verlohren S; Mueller DN; Luft FC; Dechend R
Immunology in hypertension, preeclampsia, and target-organ damage
Hypertension 54 (3): 439-443 (2009-09)
Buschmann EE; Utz W; Pagonas N; Schulz-Menger J; Busjahn A; Monti J; Maerz W; Le Noble F; Thierfelder L; Dietz R; Klauss V; Gross M; Buschmann IR
Improvement of fractional flow reserve and collateral flow by treatment with external counterpulsation (Art.Net.-2 Trial)
European Journal of Clinical Investigation 39 (10): 866-875 (2009-10)
Tintu A; Rouwet E; Verlohren S; Brinkmann J; Ahmad S; Crispi F; van Bilsen M; Carmeliet P; Staff AC; Tjwa M; Cetin I; Gratacos E; Hernandez-Andrade E; Hofstra L; Jacobs M; Lamers WH; Morano I; Safak E; Ahmed A; le Noble F
Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism, intervention, and long-term consequences
PLoS ONE 4 (4): e5155 (2009)
Herse F; Verlohren S; Wenzel K; Pape J; Mueller DN; Modrow S; Wallukat G; Luft FC; Redman CW; Dechend R
Prevalence of agonistic autoantibodies against the angiotensin II type 1 receptor and soluble fms-like tyrosine kinase 1 in a gestational age-matched case study
Hypertension 53 (2): 393-398 (2009-02)
2008
Le Noble F; Klein C; Tintu A; Pries A; Buschmann I
Neural guidance molecules, tip cells and mechanical factors in vascular development
Cardiovascular Research 78 (2): 232-241 (2008-05-01)
Buschmann IR; Lehmann K; Le Noble F
Physics meets molecules: is modulation of shear stress the link to vascular prevention?
Circulation Research 102 (5): 510-512 (2008-03-14)
Verlohren S; Niehoff M; Hering L; Geusens N; Herse F; Tintu AN; Plagemann A; Le Noble F; Pijnenborg R; Mueller DN; Luft FC; Dudenhausen JW; Gollasch M; Dechend R
Uterine vascular function in a transgenic preeclampsia rat model
Hypertension 51 (2): 547-553 (2008-02)
Geusens N; Verlohren S; Luyten C; Taube M; Hering L; Vercruysse L; Hanssens M; Dudenhausen JW; Dechend R; Pijnenborg R
Endovascular trophoblast invasion, spiral artery remodelling and uteroplacental haemodynamics in a transgenic rat model of pre-eclampsia
Placenta 29 (7): 614-623 (2008-07)
Al-Kilani A; Lorthois S; Nguyen TH; Le Noble F; Cornelissen A; Unbekandt M; Boryskina O; Leroy L; Fleury V
During vertebrate development, arteries exert a morphological control over the venous pattern through physical factors
Physical Review E 77 (5 Pt 1): 051912 (2008-05)
Crispi F; Hernandez-Andrade E; Pelsers MM; Plasencia W; Benavides-Serralde JA; Eixarch E; Le Noble F; Ahmed A; Glatz JF; Nicolaides KH; Gratacos E
Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses
American Journal of Obstetrics and Gynecology 199 (3): 254.e1-254.e8 (2008-09)
Hering L; Herse F; Verlohren S; Park JK; Wellner M; Qadri F; Pijnenborg R; Staff AC; Huppertz B; Mueller DN; Luft FC; Dechend R
Trophoblasts reduce the vascular smooth muscle cell proatherogenic response
Hypertension 51 (2): 554-559 (2008-02)
2007
Suchting S; Freitas C; le Noble F; Benedito R; Breant C; Duarte A; Eichmann A
The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching
Proceedings of the National Academy of Sciences of the United States of America 104: 3225-3230 (2007-02-27)
Verlohren S; Geusens N; Luyten C; Taube M; Hering L; Vercruysse L; Hanssens M; Dudenhausen JW; Dechend R; Pijnenborg R; Henrich W
OC247: Uteroplacental hemodynamics and trophoblast invasion in a transgenic rat model of pre-eclampsia
Ultrasound in Obstetrics and Gynecology 30: 443 (2007-10-11)
Tintu AN; Le Noble FA; Rouwet EV
Hypoxia disturbs fetal hemodynamics and growth
Endothelium 14 (6): 353-60 (2007-11)
Suchting S; Freitas C; Le Noble F; Benedito R; Breant C; Duarte A; Eichmann A
Negative regulators of vessel patterning
Novartis Foundation Symposium 283 - Vascular Development 283 (283): 77-80 (2007-09-11)
2006
Jones EA; le Noble F; Eichmann A
What determines blood vessel structure? Genetic prespecification vs. hemodynamics
Physiology 21: 388-395 (2006-12-01)
Ahmad S; Hewett PW; Wang P; Al-Ani B; Cudmore M; Fujisawa T; Haigh JJ; le Noble F; Wang L; Mukhopadhyay D; Ahmed A
Direct evidence for endothelial vascular endothelial growth factor receptor-1 function in nitric oxide-mediated angiogenesis
Circulation Research 99: 715-722 (2006-09-29)
Nguyen TH; Eichmann A; Le Noble F; Fleury V
Dynamics of vascular branching morphogenesis: the effect of blood and tissue flow
Physical Review E 73 (6 Pt 1): 061907 (2006-06)
2005
Eichmann A; Le Noble F; Autiero M; Carmeliet P
Guidance of vascular and neural network formation
Current Opinion in Neurobiology 15 (1): 108-115 (2005-02)
Le Noble F; Fleury V; Pries A; Corvol P; Eichmann A; Reneman RS
Control of arterial branching morphogenesis in embryogenesis: go with the flow
Cardiovascular Research 65 (3): 619-628 (2005-02-15)
2004
Lu X; Le Noble F; Yuan L; Jiang Q; De Lafarge B; Sugiyama D; Breant C; Claes F; De Smet F; Thomas JL; Autiero M; Carmeliet P; Tessier-Lavigne M; Eichmann A
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
Nature 432 (7014): 179-186 (2004-11-11)
Tournaire R; Simon MP; Le Noble FA; Eichmann A; England P; Pouyssegur J
A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by Tie2 receptor
EMBO Reports 5 (3): 262-267 (2004-03)
Le Noble F; Moyon D; Pardanaud L; Yuan L; Djonov V; Matthijsen R; Breant C; Fleury V; Eichmann A
Flow regulates arterial-venous differentiation in the chick embryo yolk sac
Development 131 (2): 361-375 (2004-01)
2002
Rouwet EV; Tintu AN; Schellings MW; van Bilsen M; Lutgens E; Hofstra L; Slaaf DW; Ramsay G; Le Noble FA
Hypoxia induces aortic hypertrophic growth, left ventricular dysfunction, and sympathetic hyperinnervation of peripheral arteries in the chick embryo
Circulation 105 (23): 2791-2796 (2002-06-11)
2000
Rouwet EV; De Mey JG; Slaaf DW; Heineman E; Ramsay G; Le Noble FA
Development of vasomotor responses in fetal mesenteric arteries
American Journal of Physiology Heart and Circulatory Physiology 279 (3): H1097-H1105 (2000-09)
Le Noble FA; Ruijtenbeek K; Gommers S; De Mey JG; Blanco CE
Contractile and relaxing reactivity in carotid and femoral arteries of chicken embryos
American Journal of Physiology Heart and Circulatory Physiology 278 (4): H1261-H1268 (2000-04)
Ruijtenbeek K; Le Noble FA; Janssen GM; Kessels CG; Fazzi GE; Blanco CE; De Mey JG
Chronic hypoxia stimulates periarterial sympathetic nerve development in chicken embryo
Circulation 102 (23): 2892-2897 (2000-12-05)
1999
Maas JW; Le Noble FA; Dunselman GA; de Goeij AF; Struyker-Boudier HA; Evers JL
The chick embryo chorioallantoic membrane as a model to investigate the angiogenic properties of human endometrium
Gynecologic and Obstetric Investigation 48 (2): 108-112 (1999)
1998
Le Noble FA; Stassen FR; Hacking WJ; Struijker-Boudier HA
Angiogenesis and hypertension
Journal of Hypertension 16 (11): 1563-1572 (1998-11)
1996
Le Noble FA; Kessels-van Wylick LC; Hacking WJ; Slaaf DW; Oude Egbrink MG; Struijker-Boudier HA
The role of angiotensin II and prostaglandins in arcade formation in a developing microvascular network
Journal of Vascular Research 33 (6): 480-8 (1996-11)
1993
Le Noble FA; Schreurs NH; van Straaten HW; Slaaf DW; Smits JF; Rogg H; Struijker-Boudier HA
Evidence for a novel angiotensin II receptor involved in angiogenesis in chick embryo chorioallantoic membrane
American Journal of Physiology 264 (2 Pt 2): R460-R465 (1993-02)
1992
Struijker Boudier HA; Le Noble JL; Messing MW; Huijberts MS; Le Noble FA; van Essen H
The microcirculation and hypertension
Journal of Hypertension 10 (Suppl 7): S147-S156 (1992-12)
1991
Le Noble FA; Hekking JW; Van Straaten HW; Slaaf DW; Struyker Boudier HA
Angiotensin II stimulates angiogenesis in the chorio-allantoic membrane of the chick embryo
European Journal of Pharmacology - Molecular Pharmacology Section 195 (2): 305-306 (1991-03-26)
1990
Struyker-Boudier HA; Le Noble JL; Le Noble FA; Messing MW; van Essen H
Hypertension, the microcirculation and serotonin
Clinical Physiology and Biochemistry 8 (Suppl 3): 28-39 (1990)