Publications
2012
Adameyko I; Lallemend F; Furlan A; Zinin N; Aranda S; Kitambi SS; Blanchart A; Favaro R; Nicolis S; Luebke M; Mueller T; Birchmeier C; Suter U; Zaitoun I; Takahashi Y; Ernfors P
Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest
Development 139 (2): 397-410 (2012-01-15)
John A; Brylka H; Wiegreffe C; Simon R; Liu P; Juettner R; Crenshaw EB; Luyten FP; Jenkins NA; Copeland NG; Birchmeier C; Britsch S
Bcl11a is required for neuronal morphogenesis and sensory circuit formation in dorsal spinal cord development
Development 139 (10): 1831-1841 (2012-05)
Simon R; Brylka H; Schwegler H; Venkataramanappa S; Andratschke J; Wiegreffe C; Liu P; Fuchs E; Jenkins NA; Copeland NG; Birchmeier C; Britsch S
A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis
EMBO Journal : (2012-05-15)
Wende H; Lechner SG; Cheret C; Bourane S; Kolanczyk ME; Pattyn A; Reuter K; Munier FL; Carroll P; Lewin GR; Birchmeier C
The transcription factor c-Maf controls touch receptor development and function
Science 335 (6074): 1373-1376 (2012-03-16)
Gherardi E; Birchmeier W; Birchmeier C; Woude GV
Targeting MET in cancer: rationale and progress
Nature Reviews Cancer 12 (2): 89-103 (2012-01-24)
2011
D'Autreaux F; Coppola E; Hirsch MR; Birchmeier C; Brunet JF
Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways
Proceedings of the National Academy of Sciences of the United States of America 108 (50): 20018-20023 (2011-12-13)
Fricker FR; Lago N; Balarajah S; Tsantoulas C; Tanna S; Zhu N; Fageiry SK; Jenkins M; Garratt AN; Birchmeier C; Bennett DL
Axonally derived neuregulin-1 is required for remyelination and regeneration after nerve injury in adulthood
Journal of Neuroscience 31 (9): 3225-3233 (2011-03-02)
2010
Birchmeier C
Development and more
Seminars in Cell & Developmental Biology 21 (8): 812-813 (2010-10)
Newbern J; Birchmeier C
Nrg1/ErbB signaling networks in Schwann cell development and myelination
Seminars in Cell & Developmental Biology 21 (9): 922-988 (2010-12)
Lai D; Forrai A; Liu X; Wolstein O; Michalicek J; Ahmed I; Garratt AN; Birchmeier C; Zhou M; Hartley L; Robb L; Feneley MP; Fatkin D; Harvey RP
Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardium
Circulation Research 107 (6): 715-727 (2010-09-17)
Grossmann KS; Rosario M; Birchmeier C; Birchmeier W
The tyrosine phosphatase Shp2 in development and cancer
Advances in Cancer Research 106: 53-89 (2010)
2009
Storm R; Cholewa-Waclaw J; Reuter K; Broehl D; Sieber M; Treier M; Mueller T; Birchmeier C
The bHLH transcription factor Olig3 marks the dorsal neuroepithelium of the hindbrain and is essential for the development of brainstem nuclei
Development 136 (2): 295-305 (2009-01)
Birchmeier C
ErbB receptors and the development of the nervous system
Experimental Cell Research 315 (4): 611-618 (2009-02-15)
Giebeler A; Boekschoten MV; Klein C; Borowiak M; Birchmeier C; Gassler N; Wasmuth HE; Mueller M; Trautwein C; Streetz KL
c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile-duct-ligation in mice
Gastroenterology 137 (1): 297-308 (2009-07)
Freese C; Garratt AN; Fahrenholz F; Endres K
The effects of alpha-secretase ADAM10 on the proteolysis of neuregulin-1
FEBS Journal 276 (6): 1568-1580 (2009-03)
Vasyutina E; Martarelli B; Brakebusch C; Wende H; Birchmeier C
The small G-proteins Rac1 and Cdc42 are essential for myoblast fusion in the mouse
Proceedings of the National Academy of Sciences of the United States of America 106 (22): 8935-8940 (2009-06-02)
Dubreuil V; Thoby-Brisson M; Rallu M; Persson K; Pattyn A; Birchmeier C; Brunet JF; Fortin G; Goridis C
Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons
Journal of Neuroscience 29 (47): 14836-14846 (2009-11-25)
Jacob J; Storm R; Castro DS; Milton C; Pla P; Guillemot F; Birchmeier C; Briscoe J
Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain
Development 136 (14): 2477-2485 (2009-07)
Fricker FR; Zhu N; Tsantoulas C; Abrahamsen B; Nassar MA; Thakur M; Garratt AN; Birchmeier C; McMahon SB; Wood JN; Bennett DL
Sensory axon-derived neuregulin-1 is required for axoglial signaling and normal sensory function but not for long-term axon maintenance
Journal of Neuroscience 29 (24): 7667-7678 (2009-06-17)
Birchmeier C
A fresh breeze from the ivory tower
Current Opinion in Cell Biology 21 (6): 725-726 (2009-12)
Trimbuch T; Beed P; Vogt J; Schuchmann S; Maier N; Kintscher M; Breustedt J; Schuelke M; Streu N; Kieselmann O; Brunk I; Laube G; Strauss U; Battefeld A; Wende H; Birchmeier C; Wiese S; Sendtner M; Kawabe H; Kishimoto-Suga M; Brose N; Baumgart J; Geist B; Aoki J; Savaskan NE; Braeuer AU; Chun J; Ninnemann O; Schmitz D; Nitsch R
Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling
Cell 138 (6): 1222-12235 (2009-09-18)
Grossmann KS; Wende H; Paul FE; Cheret C; Garratt AN; Zurborg S; Feinberg K; Besser D; Schulz H; Peles E; Selbach M; Birchmeier W; Birchmeier C
The tyrosine phosphatase Shp2 (PTPN11) directs neuregulin-1/ErbB signaling throughout schwann cell development
Proceedings of the National Academy of Sciences of the United States of America 106 (39): 16704-16709 (2009-09-29)
Adameyko I; Lallemend F; Aquino JB; Pereira JA; Topilko P; Mueller T; Fritz N; Beljajeva A; Mochii M; Liste I; Usoskin D; Suter U; Birchmeier C; Ernfors P
Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin
Cell 139 (2): 366-379 (2009-10-16)
2008
Marx-Stoelting P; Borowiak M; Knorpp T; Birchmeier C; Buchmann A; Schwarz M
Hepatocarcinogenesis in mice with a conditional knockout of the hepatocyte growth factor receptor c-Met
International Journal of Cancer 124 (8): 1767-1772 (2008-04-15)
Wildner H; Gierl MS; Strehle M; Pla P; Birchmeier C
Insm1 (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympatho-adrenal lineage
Development 135 (3): 473-81 (2008-02)
Farkas LM; Haffner C; Giger T; Khaitovich P; Nowick K; Birchmeier C; Paeaebo S; Huttner WB
Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of Basal progenitors in the developing mouse neocortex
Neuron 60 (1): 40-55 (2008-10-09)
Caubit X; Lye CM; Martin E; Core N; Long DA; Vola C; Jenkins D; Garratt AN; Skaer H; Woolf AS; Fasano L
Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4
Development 135 (19): 3301-3310 (2008-10)
Birchmeier C; Nave KA
Neuregulin-1, a key axonal signal that drives Schwann cell growth and differentiation
Glia 56 (14): 1491-1497 (2008-11-01)
Hori K; Cholewa-Waclaw J; Nakada Y; Glasgow SM; Masui T; Henke RM; Wildner H; Martarelli B; Beres TM; Epstein JA; Magnuson MA; Macdonald RJ; Birchmeier C; Johnson JE
A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling
Genes & Development 22 (2): 166-178 (2008-01-15)
Broehl D; Strehle M; Wende H; Hori K; Bormuth I; Nave KA; Mueller T; Birchmeier C
A transcriptional network coordinately determines transmitter and peptidergic fate in the dorsal spinal cord
Developmental Biology 322 (2): 381-393 (2008-10-15)
Brinkmann BG; Agarwal A; Sereda MW; Garratt AN; Mueller T; Wende H; Stassart RM; Nawaz S; Humml C; Velanac V; Radyushkin K; Goebbels S; Fischer TM; Franklin RJ; Lai C; Ehrenreich H; Birchmeier C; Schwab MH; Nave KA
Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system
Neuron 59 (4): 581-595 (2008-08-28)
2007
Sieber MA; Storm R; Martinez-de-la-Torre M; Mueller T; Wende H; Reuter K; Vasyutina E; Birchmeier C
Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons in the hindbrain
Journal of Neuroscience 27 (18): 4902-4909 (2007-05-02)
Chmielowiec J; Borowiak M; Morkel M; Stradal T; Munz B; Werner S; Wehland J; Birchmeier C; Birchmeier W
c-Met is essential for wound healing in the skin
Journal of Cell Biology 177 (1): 151-162 (2007-04-09)
Vasyutina E; Lenhard DC; Birchmeier C
Notch function in myogenesis
Cell Cycle 6 (12): 1451-1454 (2007-06-15)
Grego-Bessa J; Luna-Zurita L; Del Monte G; Bolos V; Melgar P; Arandilla A; Garratt AN; Zang H; Mukouyama YS; Chen H; Shou W; Ballestar E; Esteller M; Rojas A; Perez-Pomares JM; de la Pompa JL
Notch signaling is essential for ventricular chamber development
Developmental Cell 12: 415-429 (2007-03-01)
Vasyutina E; Lenhard DC; Wende H; Erdmann B; Epstein JA; Birchmeier C
RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells
Proceedings of the National Academy of Sciences of the United States of America 104 (11): 4443-4448 (2007-03-13)
Potzner MR; Griffel C; Lutjen-Drecoll E; Boesl MR; Wegner M; Sock E
Prolonged Sox4 expression in oligodendrocytes interferes with normal myelination in the central nervous system
Molecular and Cellular Biology 27 (15): 5316-5326 (2007-08)
Wulczyn FG; Smirnova L; Rybak A; Brandt C; Kwidzinski E; Ninnemann O; Strehle M; Seiler A; Schumacher S; Nitsch R
Post-transcriptional regulation of the let-7 microRNA during neural cell specification
FASEB Journal 21: 415-426 (2007-02-01)
Milenkovic N; Frahm C; Gassmann M; Griffel C; Erdmann B; Birchmeier C; Lewin GR; Garratt AN
Nociceptive tuning by stem cell factor/c-Kit signaling
Neuron 56 (5): 893-906 (2007-12-06)
Zechner D; Mueller T; Wende H; Walther I; Taketo MM; Crenshaw EB; Treier M; Birchmeier W; Birchmeier C
Bmp and Wnt/beta-catenin signals control expression of the transcription factor Olig3 and the specification of spinal cord neurons
Developmental Biology 303 (1): 181-190 (2007-03-01)
2006
Vasyutina E; Birchmeier C
The development of migrating muscle precursor cells
Anatomy and Embryology 211 (Suppl.): S37-S41 (2006-12)
Willem M; Garratt AN; Novak B; Citron M; Kaufmann S; Rittger A; Destrooper B; Saftig P; Birchmeier C; Haass C
Control of peripheral nerve myelination by the {beta}-secretase BACE1
Science 314: 664-666 (2006-10-27)
Wildner H; Mueller T; Cho SH; Broehl D; Cepko CL; Guillemot F; Birchmeier C
dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development
Development 133 (11): 2105-2113 (2006-06)
Gierl MS; Karoulias N; Wende H; Strehle M; Birchmeier C
The Zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells
Genes & Development 20 (17): 2465-2478 (2006-09-01)
Mueller T
Neural development
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2 : 1258-1266 (2006-07-05)
Garratt AN
"To erb-B or not to erb-B..." Neuregulin-1/ErbB signaling in heart development and function
Journal of Molecular and Cellular Cardiology 41 (2): 215-218 (2006-08)
Atanasoski S; Scherer SS; Sirkowski E; Leone D; Garratt AN; Birchmeier C; Suter U
ErbB2 signaling in Schwann cells is mostly dispensable for maintenance of myelinated peripheral nerves and proliferation of adult Schwann cells after injury
Journal of Neuroscience 26 (7): 2124-2131 (2006-02-15)
Lopez-Bendito G; Cautinat A; Sanchez JA; Bielle F; Flames N; Garratt AN; Talmage DA; Role LW; Charnay P; Marin O; Garel S
Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation
Cell 125: 127-142 (2006-04-07)
Britsch S
Transgenic and knock-out animals
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2 : 1900-1903 (2006-07-05)
2005
Vasyutina E; Stebler J; Brand-Saberi B; Schulz S; Raz E; Birchmeier C
CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells
Genes & Development 19 (18): 2187-2198 (2005-09-15)
John A; Wildner H; Britsch S
The homeodomain transcription factor Gbx1 identifies a subpopulation of late-born GABAergic interneurons in the developing dorsal spinal cord
Developmental Dynamics 234: 767-771 (2005-09-28)
Pohlers M; Truss M; Frede U; Scholz A; Strehle M; Kuban RJ; Hoffmann B; Morkel M; Birchmeier C; Hagemeier C
A role for E2F6 in the restriction of male-germ-cell-specific gene expression
Current Biology 15: 1051-1057 (2005-01-01)
Humphries JD; Schofield NR; Mostafavi-Pour Z; Green LJ; Garratt AN; Mould AP; Humphries MJ
Dual functionality of the anti-beta1 integrin antibody, 12G10, exemplifies agonistic signalling from the ligand binding pocket of integrin adhesion receptors
Journal of Biological Chemistry 280: 10234-10243 (2005-03-18)
Mueller T; Anlag K; Wildner H; Britsch S; Treier M; Birchmeier C
The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord
Genes & Development 19: 733-743 (2005-01-01)
2004
Michailov GV; Sereda MW; Brinkmann BG; Fischer TM; Haug B; Birchmeier C; Role L; Lai C; Schwab MH; Nave KA
Axonal neuregulin-1 regulates myelin sheath thickness
Science 304 (5671): 700-703 (2004-04-30)
Graveel C; Su Y; Koeman J; Wang LM; Tessarollo L; Fiscella M; Birchmeier C; Swiatek P; Bronson R; Vande Woude GF
Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele
Proceedings of the National Academy of Sciences of the United States of America 101: 17198-17203 (2004-12-07)
Flames N; Long JE; Garratt AN; Fischer TM; Gassmann M; Birchmeier C; Lai C; Rubenstein JL; Marin O
Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1
Neuron 44: 251-261 (2004-10-14)
Borowiak M; Garratt AN; Wuestefeld T; Strehle M; Trautwein C; Birchmeier C
Met provides essential signals for liver regeneration
Proceedings of the National Academy of Sciences of the United States of America 101: 10608-10613 (2004-01-01)
2003
Zechner D; Fujita Y; Huelsken J; Mueller T; Walther I; Taketo MM; Crenshaw EB; Birchmeier W; Birchmeier C
beta-catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system
Developmental Biology 258: 406-418 (2003-01-01)
Britsch S; Strehle M; Birchmeier C
Tiermodelle in der biomedizinischen Forschung
Grundlagen der Molekularen Medizin : 299-339 (2003-01-01)
Birchmeier C; Birchmeier W; Gherardi E; Vande Woude GF
Met, metastasis, motility and more
Nature Reviews Molecular Cell Biology 4 (12): 915-925 (2003-12)
Garratt AN; Ozcelik C; Birchmeier C
ErbB2 pathways in heart and neural diseases
Trends in Cardiovascular Medicine 13: 80-86 (2003-01-01)
Young HM; Bergner AJ; Mueller T
Acquisition of neuronal and glial markers by neural crest-derived cells in the mouse intestine
Journal of Comparative Neurology 456: 1-11 (2003-01-01)
2002
Mueller T; Brohmann H; Pierani A; Heppenstall PA; Lewin GR; Jessell TM; Birchmeier C
The homeodomain factor Lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord
Neuron 34 (4): 551-562 (2002-01-01)
Li L; Cleary S; Mandarano MA; Long WW; Birchmeier C; Jones FE
The breast proto-oncogene, HRGalpha regulates epithelial proliferation and lobuloalveolar development in the mouse mammary gland
Oncogene 21: 4900-4907 (2002-01-01)
Hippenmeyer S; Shneider NA; Birchmeier C; Burden SJ; Jessell TM; Arber S
A role for Neuregulin1 signaling in muscle spindle differentiation
Neuron 36: 1035-1049 (2002-01-01)
Schneider JW; Chang AY; Garratt A
Trastuzumab cardiotoxicity: Speculations regarding pathophysiology and targets for further study
Seminars in Oncology 29: 22-28 (2002-01-01)
Oezcelik C; Erdmann B; Pilz B; Wettschureck N; Britsch S; Huebner N; Chien KR; Birchmeier C; Garratt AN
Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy
Proceedings of the National Academy of Sciences of the United States of America 99: 8880-8885 (2002-01-01)
Mukouyama Y; Shin D; Britsch S; Taniguchi M; Anderson DJ
Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin
Cell 109 (6): 693-705 (2002-01-01)
2001
Birchmeier C; Treier M
Genomics boosts mouse molecular genetics
Trends in Genetics 17: 691-692 (2001-12-01)
Keilhack H; Mueller M; Boehmer SA; Frank C; Weidner KM; Birchmeier W; Ligensa T; Berndt A; Kosmehl H; Gunther B; Mueller T; Birchmeier C; Boehmer FD
Negative regulation of Ros receptor tyrosine kinase signaling: An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1
Journal of Cell Biology 152 (2): 325-334 (2001-01-22)
Britsch S; Goerich DE; Riethmacher D; Peirano RI; Rossner M; Nave KA; Birchmeier C; Wegner M
The transcription factor Sox10 is a key regulator of peripheral glial development
Genes & Development 15 (1): 66-78 (2001-01-01)
Yang X; Arber S; William C; Li L; Tanabe Y; Jessell TM; Birchmeier C; Burden SJ
Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation
Neuron 30: 399-410 (2001-01-01)
2000
Garratt AN; Voiculescu O; Topilko P; Charnay P; Birchmeier C
A dual role of erbB2 in myelination and in expansion of the Schwann cell precursor pool
Journal of Cell Biology 148 (5): 1035-1046 (2000-03-06)
Caton A; Hacker A; Naeem A; Livet J; Maina F; Bladt F; Klein R; Birchmeier C; Guthrie S
The branchial arches and HGF are growth-promoting and chemoattractant for cranial motor axons
Development 127: 1751-1766 (2000-04-01)
Rosenthal N; Birchmeier C
Cell differentiation
Current Opinion in Cell Biology 12: 717-718 (2000-12-01)
Brohmann H; Jagla K; Birchmeier C
The role of Lbx1 in migration of muscle precursor cells
Development 127: 437-445 (2000-01-01)
Garratt AN; Britsch S; Birchmeier C
Neuregulin, a factor with many functions in the life of schwann cell
BioEssays 22 (11): 987-996 (2000-11)
Sachs M; Brohmann H; Zechner D; Mueller T; Huelsken J; Walther I; Schaeper U; Birchmeier C; Birchmeier W
Essential role of Gab1 for signaling by the c-Met receptor in vivo
Journal of Cell Biology 150 (6): 1375-1384 (2000-09-18)
Smits R; Ruiz P; Diaz-Cano S; Luz A; Jagmohan-Changur S; Breukel C; Birchmeier C; Birchmeier W; Fodde R
E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice
Gastroenterology 119 (4): 1045-1053 (2000-10-01)
Birchmeier C; Brohmann H
Genes that control the development of migrating muscle precursor cells
Current Opinion in Cell Biology 12: 725-730 (2000-12-01)
Huelsken J; Vogel R; Brinkmann V; Erdmann B; Birchmeier C; Birchmeier W
Requirement for beta-catenin in anterior-posterior axis formation in mice
Journal of Cell Biology 148 (3): 567-578 (2000-02-07)
1999
Woldeyesus MT; Britsch S; Riethmacher D; Xu L; Sonnenberg-Riethmacher E; Abou-Rebyeh F; Harvey R; Caroni P; Birchmeier C
Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development
Genes & Development 13: 2538-2548 (1999-10-01)
Gaio U; Schweickert A; Fischer A; Garratt AN; Mueller T; Oezcelik C; Lankes W; Strehle M; Britsch S; Blum M; Birchmeier C
A role of the cryptic gene in the correct establishment of the left-right axis
Current Biology 9: 1339-1342 (1999-11-18)
Kotlyarov A; Neininger A; Schubert C; Eckert R; Birchmeier C; Volk HD; Gaestel M
MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis
Nature Cell Biology 1: 94-97 (1999-06-01)
Birchmeier W; Birchmeier C
Epithelial Morphogenesis in Development and Disease
: (1999-01-01)
Birchmeier W; Birchmeier C; Brinkmann V; Niemann C
10. Tyrosine kinase receptors as driving forces for growth, motility and differentiation of epithelial cells
Epithelial Morphogenesis in Development and Disease : 217-231 (1999-01-01)
Dietrich S; Abou-Rebyeh F; Brohmann H; Bladt F; Yamaai T; Lumsden A; Brand-Saberi B; Birchmeier C
The role of SF/HGF and c-Met in the development of skeletal muscle
Development 126: 1621-1629 (1999-04-01)
1998
Hartmann G; Prospero T; Brinkmann V; Ozcelik O; Winter G; Hepple J; Batley S; Bladt F; Sachs M; Birchmeier C; Birchmeier W; Gherardi E
Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo
Current Biology 8 (3): 125-134 (1998-01-29)
Walther T; Balschun D; Voigt JP; Fink H; Zuschratter W; Birchmeier C; Ganten D; Bader M
Sustained long-term potentiation and anxiety in mice lacking the Mas protooncogene
Journal of Biological Chemistry 273: 11867-11873 (1998-01-01)
Britsch S; Li L; Kirchhoff S; Theuring F; Brinkmann V; Birchmeier C; Riethmacher D
The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system
Genes & Development 12: 1825-1836 (1998-01-01)
Birchmeier C; Gherardi E
Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase
Trends in Cell Biology 8 (10): 404-410 (1998-10-01)
1997
Riethmacher D; Sonnenberg-Riethmacher E; Brinkmann V; Yamaai T; Lewin GR; Birchmeier C
Severe neuropathies in mice with targeted mutations in the ErbB3 receptor
Nature 389 (6652): 725-730 (1997-10-16)
Birchmeier C; Bladt F; Yamaai T
The functions of HGF/SF and its receptor, the c-Met tyrosine kinase, in mammalian development
Ciba Foundation Symposia 212: 169-177, discussion 177-82. (1997-01-01)
Birchmeier C; Bladt F; Britsch S
Tiermodelle in der biomedizinischen Forschung
Molekular- und Zellbiologische Grundlagen : 338-358 (1997-01-01)
Meyer D; Yamaai T; Garratt A; Riethmacher-Sonnenberg E; Kane D; Theill LE; Birchmeier C
Isoform specific expression and function of neuregulin
Development 124 (18): 3575-3586 (1997-09)
Birchmeier C; Riethmacher D; Brinkmann V
Morphogenesis of epithelial cells
Adhesion Molecules in Health and Disease : 205-222 (1997-01-01)
Ebens A; Brose K; Leonardo ED; Hanson MG; Bladt F; Birchmeier C; Barres BA; Tessierlavigne M
Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons
Neuron 17 (6): 1157-1172 (1997-12-01)
Kjelsberg C; Sakurai H; Spokes K; Birchmeier C; Drummond I; Nigam S; Cantley LG
Met -/- kidneys express epithelial cells that chemotax and form tubules in response to EGF receptor ligands
American Journal of Physiology Renal Physiology 272: F222-F228 (1997-01-01)
1996
Birchmeier W; Behrens J; Weidner KM; Huelsken J; Birchmeier C
Epithelial differentiation and the control of metastasis in carcinomas
Attempts to Understand Metastasis Formation II : 117-135 (1996-01-01)
Ruiz P; Brinkmann V; Ledermann B; Behrend M; Grund C; Thalhammer C; Vogel F; Birchmeier C; Guenthert U; Franke WW; Birchmeier W
Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart
Journal of Cell Biology 135 (1): 215-225 (1996-10)
Sonnenberg-Riethmacher E; Walter B; Riethmacher D; Goedecke S; Birchmeier C
The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis
Genes & Development 10 (10): 1184-1193 (1996-01-01)
Birchmeier C; Birchmeier W; Brand-Saberi B
Epithelial-mesenchymal transitions in cancer progression
Acta Anatomica 156: 217-226 (1996-01-01)
Brand-Saberi B; Mueller TS; Wilting J; Christ B; Birchmeier C
Scatter factor hepatocyte growth factor (sf/hgf) induces emigration of myogenic cells at interlimb level in vivo
Developmental Biology 179: 303-308 (1996-01-01)
1995
Meyer D; Birchmeier C
Multiple essential functions of neuregulin in development
Nature 378 (6555): 386-390 (1995-11-23)
Bladt F; Riethmacher D; Isenmann S; Aguzzi A; Birchmeier C
Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
Nature 376 (6543): 768-771 (1995-08-31)
Birchmeier W; Birchmeier C
Epithelial-mesenchymal transitions in development and tumor progression
Epithelial-Mesenchymal Interactions in Cancer : 1-16 (1995-01-01)
Yang Y; Spitzer E; Meyer D; Sachs M; Niemann C; Hartmann G; Weidner KM; Birchmeier C; Birchmeier W
Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland
Journal of Cell Biology 131 (1): 215-226 (1995-10)
Birchmeier C; Meyer D; Riethmacher D
Factors controlling growth, motility, and morphogenesis of normal and malignant epithelial cells
International Review of Cytology 160: 221-266 (1995-01-01)
Schmidt C; Bladt F; Goedecke S; Brinkmann V; Zschiesche W; Sharpe M; Gherardi E; Birchmeier C
Scatter factor/hepatocyte growth factor is essential for liver development
Nature 373 (6515): 699-702 (1995-02-23)
Riethmacher D; Brinkmann V; Birchmeier C
A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development
Proceedings of the National Academy of Sciences of the United States of America 92 (3): 855-859 (1995-01-31)
1994
Riethmacher D; Langholz O; Goedecke S; Sachs M; Birchmeier C
Biochemical and functional characterization of the murine ros protooncogene
Oncogene 9 (12): 3617-3626 (1994-12)
Birchmeier W; Birchmeier C
Mesenchymal-epithelial transitions
BioEssays 16: 305-307 (1994-01-01)
Meyer D; Birchmeier C
Distinct isoforms of neuregulin are expressed in mesenchymal and neuronal cells during mouse development
Proceedings of the National Academy of Sciences of the United States of America 91: 1064-1068 (1994-01-01)
1993
Bladt F; Birchmeier C
Characterization and expression analysis of the murine rck gene - a protein-kinase with a potential function in sensory cells
Differentiation 53: 115-122 (1993-01-01)
Birchmeier C; Sonnenberg E; Weidner KM; Walter B
Tyrosine kinase receptors in the control of epithelial growth and morphogenesis during development
BioEssays 15: 185-190 (1993-01-01)
Birchmeier C; Birchmeier W
Molecular aspects of mesenchymal-epithelial interactions
Annual Review of Cell Biology 9: 511-540 (1993)
Durbeej M; Soederstroem S; Ebendal T; Birchmeier C; Ekblom P
Differential expression of neurotrophin receptors during renal development
Development 119 (4): 977-989 (1993-12)
Sonnenberg E; Meyer D; Weidner KM; Birchmeier C
Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development
Journal of Cell Biology 123 (1): 223-235 (1993-10-01)
Sonnenberg E; Weidner KM; Birchmeier C
Expression of the met-receptor and its ligand, HGF-SF during mouse embryogenesis
Hepatocyte Growth Factor-Scatter Factor (HGF-SF) and the C-Met-Receptor : 381-394 (1993-01-01)