Publications
2012
Orthmann A; Zeisig R; Suess R; Lorenz D; Lemm M; Fichtner I
Treatment of experimental brain metastasis with MTO-liposomes: impact of fluidity and LRP-targeting on the therapeutic result
Pharmaceutical Research : (2012-03-08)
Sokolenko AP; Iyevleva AG; Preobrazhenskaya EV; Mitiushkina NV; Abysheva SN; Suspitsin EN; Kuligina ES; Gorodnova TV; Pfeifer W; Togo AV; Turkevich EA; Ivantsov AO; Voskresenskiy DV; Dolmatov GD; Bit-Sava EM; Matsko DE; Semiglazov VF; Fichtner I; Larionov AA; Kuznetsov SG; Antoniou AC; Imyanitov EN
High prevalence and breast cancer predisposing role of the BLMc.1642 C>T (Q548X) mutation in Russia
International Journal of Cancer 130 (12): 2867-2873 (2012-06-15)
2011
Abolhassani M; Guais A; Sanders E; Campion F; Fichtner I; Bonte J; Baronzio G; Fiorentini G; Israel M; Schwartz L
Screening of well-established drugs targeting cancer metabolism: reproducibility of the efficacy of a highly effective drug combination in mice
Investigational New Drugs : (2011-06-09)
Sack U; Walther W; Scudiero D; Selby M; Kobelt D; Lemm M; Fichtner I; Schlag PM; Shoemaker RH; Stein U
Novel effect of antihelminthic niclosamide on S100A4-mediated metastatic progression in colon cancer
Journal of the National Cancer Institute 103 (13): 1018-1036 (2011-07-06)
Sack U; Walther W; Scudiero D; Selby M; Aumann J; Lemos C; Fichtner I; Schlag PM; Shoemaker RH; Stein U
S100A4-induced cell motility and metastasis is restricted by the Wnt/{beta}-catenin pathway inhibitor calcimycin in colon cancer cells
Molecular Biology of the Cell 22 (18): 3344-3354 (2011-09)
Bachmeier B; Fichtner I; Killian PH; Kronski E; Pfeffer U; Efferth T
Development of resistance towards artesunate in MDA-MB-231 human breast cancer cells
PLoS ONE 6 (5): e20550 (2011-05-26)
Winsel S; Sommer A; Eschenbrenner J; Mittelstaedt K; Klar U; Hammer S; Hoffmann J
Molecular mode of action and role of TP53 in the sensitivity to the novel epothilone sagopilone (ZK-EPO) in A549 non-small cell lung cancer cells
PLoS ONE 6 (4): e19273 (2011-04-29)
Bergman AM; Adema AD; Balzarini J; Bruheim S; Fichtner I; Noordhuis P; Fodstad O; Myhren F; Sandvold ML; Hendriks HR; Peters GJ
Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models
Investigational New Drugs 29 (3): 456-466 (2011-06)
Abu Ajaj K; El-Abadla N; Welker P; Azab S; Zeisig R; Fichtner I; Kratz F
Comparative evaluation of the biological properties of reducible and acid-sensitive folate prodrugs of a highly potent doxorubicin derivative
European Journal of Cancer : (2011-09-19)
Walther W; Petkov S; Kuvardina ON; Aumann J; Kobelt D; Fichtner I; Lemm M; Piontek J; Blasig IE; Stein U; Schlag PM
Novel Clostridium perfringens enterotoxin suicide gene therapy for selective treatment of claudin-3- and -4-overexpressing tumors
Gene Therapy : (2011-10-06)
Bijnsdorp IV; Schwendener RA; Schott H; Fichtner I; Smid K; Laan AC; Schott S; Losekoot N; Honeywell RJ; Peters GJ
Cellular pharmacology of multi- and duplex drugs consisting of ethynylcytidine and 5-fluoro-2'-deoxyuridine
Investigational New Drugs 29 (2): 248-257 (2011-04)
Calderon M; Welker P; Licha K; Fichtner I; Graeser R; Haag R; Kratz F
Development of efficient acid cleavable multifunctional prodrugs derived from dendritic polyglycerol with a poly (ethylene glycol) shell
Journal of Controlled Release 151 (3): 295-301 (2011-05-10)
Stein U; Arlt F; Smith J; Sack U; Herrmann P; Walther W; Lemm M; Fichtner I; Shoemaker RH; Schlag PM
Intervening in beta-catenin signaling by sulindac inhibits S100A4-dependent colon cancer metastasis
Neoplasia 13 (2): 131-144 (2011-02)
Kratz F; Fichtner I; Graeser R
Combination therapy with the albumin-binding prodrug of doxorubicin (INNO-206) and doxorubicin achieves complete remissions and improves tolerability in an ovarian A2780 xenograft model
Investigational New Drugs : (2011-05-18)
2010
Harnack U; Eckert K; Fichtner I; Pecher G
Comparison of the effect of orally administered soluble {beta}-(1-3),(1-6)-D-glucan and of G-CSF on the recovery of murine hematopoiesis
In Vivo 24 (1): 59-63 (2010-01)
Orthmann A; Zeisig R; Koklic T; Sentjurc M; Wiesner B; Lemm M; Fichtner I
Impact of membrane properties on uptake and transcytosis of colloidal nanocarriers across an epithelial cell barrier model
Journal of Pharmaceutical Sciences 99 (5): 2423-2433 (2010-05)
Brueckner B; Rius M; Rivera Markelova M; Fichtner I; Hals PA; Sandvold ML; Lyko F
Delivery of 5-azacytidine to human cancer cells by elaidic acid esterification increases therapeutic drug efficacy
Molecular Cancer Therapeutics 9 (5): 1256-1264 (2010-05)
Graeser R; Esser N; Unger H; Fichtner I; Zhu A; Unger C; Kratz F
INNO-206, the (6-maleimidocaproyl hydrazone derivative of doxorubicin), shows superior antitumor efficacy compared to doxorubicin in different tumor xenograft models and in an orthotopic pancreas carcinoma model
Investigational New Drugs 28 (1): 14-19 (2010-02)
Fichtner I; Claffey J; Deally A; Gleeson B; Hogan M; Rivera Markelova M; Mueller-Bunz H; Weber H; Tacke M
Antitumor activity of vanadocene Y and its selenocyanate derivative in xenografted CAKI-1 tumors in mice
Journal of Organometallic Chemistry 695 (8): 1175-1181 (2010-04-15)
Adema AD; Laan AC; Myhren F; Fichtner I; Verheul HM; Sandvold ML; Peters GJ
Cell cycle effects of fatty acid derivatives of cytarabine, CP-4055, and of gemcitabine, CP-4126, as basis for the interaction with oxaliplatin and docetaxel
International Journal of Oncology 36 (1): 285-294 (2010-01)
Wenzel J; Zeisig R; Fichtner I
Inhibition of metastasis in a murine 4T1 breast cancer model by liposomes preventing tumor cell-platelet interactions
Clinical and Experimental Metastasis 27 (1): 25-34 (2010)
Wenzel J; Zeisig R; Haider W; Habedank S; Fichtner I
Inhibition of pulmonary metastasis in a human MT3 breast cancer xenograft model by dual liposomes preventing intravasal fibrin clot formation
Breast Cancer Research and Treatment 121 (1): 13-22 (2010-05)
Hammer S; Sommer A; Fichtner I; Becker M; Rolff J; Merk J; Klar U; Hoffmann J
Comparative profiling of the novel epothilone, sagopilone, in xenografts derived from primary non-small cell lung cancer
Clinical Cancer Research 16 (5): 1452-1465 (2010-03-01)
2009
Fritzmann J; Morkel M; Besser D; Budczies J; Kosel F; Brembeck FH; Stein U; Fichtner I; Schlag PM; Birchmeier W
A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential
Gastroenterology 137 (11): 165-175 (2009-07)
Diaz Miqueli A; Rolff J; Lemm M; Fichtner I; Perez R; Montero E
Radiosensitisation of U87MG brain tumours by anti-epidermal growth factor receptor monoclonal antibodies
British Journal of Cancer 100 (6): 950-958 (2009-03-24)
Stein U; Walther W; Arlt F; Schwabe H; Smith J; Fichtner I; Birchmeier W; Schlag PM
MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis
Nature Medicine 15 (1): 59-67 (2009-01)
Heringer-Walther S; Eckert K; Schumacher SM; Uharek L; Wulf-Goldenberg A; Gembardt F; Fichtner I; Schultheiss HP; Rodgers K; Walther T
Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo
Haematologica 94 (6): 857-860 (2009-06)
Hoffmann J; Fichtner I; Lemm M; Lienau P; Hess-Stumpp H; Rotgeri A; Hofmann B; Klar U
Sagopilone crosses the blood-brain barrier in vivo to inhibit brain tumor growth and metastases
Neuro Oncology 11 (2): 158-166 (2009-04)
2008
Fichtner I; Rolff J; Soong R; Hoffmann J; Hammer S; Sommer A; Becker M; Merk J
Establishment of patient-derived non-small cell lung cancer xenografts as models for the identification of predictive biomarkers
Clinical Cancer Research 14 (20): 6456-6468 (2008-10-15)
Ryppa C; Mann-Steinberg H; Fichtner I; Weber H; Satchi-Fainaro R; Biniossek ML; Kratz F
In vitro and in vivo evaluation of doxorubicin conjugates with the divalent peptide E-[c(RGDfK)2] that targets integrin alphavbeta3
Bioconjugate Chemistry 19 (7): 1414-1422 (2008-07)
Stein U; Walther W; Stege A; Kaszubiak A; Fichtner I; Lage H
Complete in vivo reversal of the multidrug resistance phenotype by jet-injection of anti-MDR1 short hairpin RNA-encoding plasmid DNA
Molecular Therapy 16 (1): 178-186 (2008-01)
Koklic T; Zeisig R; Sentjurc M
Interaction of alkylphospholipid liposomes with MT-3 breast-cancer cells depends critically on cholesterol concentration
Biochimica et Biophysica Acta - Biomembranes 1778 (12): 2682-2689 (2008-12)
Wulf-Goldenberg A; Eckert K; Fichtner I
Cytokine-pretreatment of CD34(+) cord blood stem cells in vitro reduces long-term cell engraftment in NOD/SCID mice
European Journal of Cell Biology 87 (2): 69-80 (2008-02)
2007
Thirunarayanan N; Cifire F; Fichtner I; Posner S; Benga J; Reiterer P; Kremmer E; Koelble K; Lipp M
Enhanced tumorigenicity of fibroblasts transformed with human herpesvirus 8 chemokine receptor vGPCR by successive passage in nude and immunocompetent mice
Oncogene 26 (39): 5702-5712 (2007-08-23)
Yde CW; Frogne T; Lykkesfeldt AE; Fichtner I; Issinger OG; Stenvang J
Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT
Cancer Letters 256 (2): 229-237 (2007-10-28)
Schmid B; Chung DE; Warnecke A; Fichtner I; Kratz F
Albumin-Binding Prodrugs of Camptothecin and Doxorubicin with an Ala-Leu-Ala-Leu-Linker That Are Cleaved by Cathepsin B: Synthesis and Antitumor Efficacy
Bioconjugate Chemistry 18 (3): 702-716 (2007-05)
Kaufner L; Cartier R; Wuestneck R; Fichtner I; Pietschmann S; Bruhn H; Schuett D; Thuenemann AF; Pison U
Poly(ethylene oxide)-block-poly(glutamic acid) coated maghemite nanoparticles: in vitro characterization and in vivo behaviour
Nanotechnology 18 (11): 115710 (2007-03-21)
Walther W; Arlt F; Fichtner I; Aumann J; Stein U; Schlag PM
Heat-inducible in vivo gene therapy of colon carcinoma by human mdr1 promoter-regulated tumor necrosis factor-alpha expression
Molecular Cancer Therapeutics 6: 236-243 (2007-01-01)
Schmid B; Warnecke A; Fichtner I; Jung M; Kratz F
Development of albumin-binding camptothecin prodrugs using a peptide positional scanning library
Bioconjugate Chemistry 18 (6): 1786-1799 (2007-11)
Bannon JH; Fichtner I; O'Neill A; Pampillon C; Sweeney NJ; Strohfeldt K; Watson RW; Tacke M; McGee MM
Substituted titanocenes induce caspase-dependent apoptosis in human epidermoid carcinoma cells in vitro and exhibit antitumour activity in vivo
British Journal of Cancer 97 (9): 1234-1241 (2007-11-05)
2006
Walther W; Minow T; Martin R; Fichtner I; Schlag PM; Stein U
Uptake, biodistribution, and time course of naked plasmid DNA trafficking after intratumoral in vivo jet injection
Human Gene Therapy 17 (6): 611-624 (2006-06)
Shalapour S; Zelmer A; Pfau M; Moderegger E; Costa-Blechschmidt C; van Landeghem FK; Taube T; Fichtner I; Buehrer C; Henze G; Seeger K; Wellmann S
The thalidomide analogue, CC-4047, induces apoptosis signaling and growth arrest in childhood acute lymphoblastic leukemia cells in vitro and in vivo
Clinical Cancer Research 12: 5526-5532 (2006-09-15)
Einsiedel HG; Kawan L; Eckert C; Witt O; Fichtner I; Henze G; Seeger K
Histone deacetylase inhibitors have antitumor activity in two NOD/SCID mouse models of B-cell precursor childhood acute lymphoblastic leukemia
Leukemia 20: 1435-1436 (2006-08-01)
Schanzer JM; Fichtner I; Baeuerle PA; Kufer P
Antitumor activity of a dual cytokine/single-chain antibody fusion protein for simultaneous delivery of GM-CSF and IL-2 to Ep-CAM expressing tumor cells
Journal of Immunotherapy 29: 477-488 (2006-09-01)
Brischwein K; Schlereth B; Guller B; Steiger C; Wolf A; Lutterbuese R; Offner S; Locher M; Urbig T; Raum T; Kleindienst P; Wimberger P; Kimmig R; Fichtner I; Kufer P; Hofmeister R; da Silva AJ; Baeuerle PA
MT110: A novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors
Molecular Immunology 43: 1129-1143 (2006-01-01)
Besada V; Diaz M; Becker M; Ramos Y; Castellanos-Serra L; Fichtner I
Proteomics of xenografted human breast cancer indicates novel targets related to tamoxifen resistance
Proteomics 6 (3): 1038-1048 (2006-02)
Schlereth B; Kleindienst P; Fichtner I; Lorenczewski G; Brischwein K; Lippold S; Silva AD; Locher M; Kischel R; Lutterbuese R; Kufer P; Baeuerle PA
Potent inhibition of local and disseminated tumor growth in immunocompetent mouse models by a bispecific antibody construct specific for Murine CD3
Cancer Immunology Immunotherapy 55: 785-796 (2006-07-01)
2005
Schlereth B; Fichtner I; Lorenczewski G; Kleindienst P; Brischwein K; da Silva A; Kufer P; Lutterbuese R; Junghahn I; Kasimir-Bauer S; Wimberger P; Kimmig R; Baeuerle PA
Eradication of tumors from a human colon cancer cell line and from ovarian cancer metastases in immunodeficient mice by a single-chain Ep-CAM-/CD3-bispecific antibody construct
Cancer Research 65: 2882-2889 (2005-01-01)
Carstanjen D; Gross A; Kosova N; Fichtner I; Salama A
The alpha4beta1 and alpha5beta1 integrins mediate engraftment of granulocyte-colony-stimulating factor-mobilized human hematopoietic progenitor cells
Transfusion 45: 1192-1200 (2005-07-01)
Sharma AD; Cantz T; Richter R; Eckert K; Henschler R; Wilkens L; Jochheim-Richter A; Arseniev L; Ott M
Human cord blood stem cells generate human cytokeratin 18-negative hepatocyte-like cells in injured mouse liver
American Journal of Pathology 167: 555-564 (2005-08-01)
Berry JM; Bradshaw TD; Fichtner I; Ren R; Schwalbe CH; Wells G; Chew EH; Stevens MF; Westwell AD
Quinols as novel therapeutic agents. 2.(1) 4-(1-arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents
Journal of Medicinal Chemistry 48: 639-644 (2005-01-27)
Walther W; Stein U; Fichtner I; Kobelt D; Aumann J; Arlt F; Schlag PM
Nonviral jet-injection gene transfer for efficient in vivo cytosine deaminase suicide gene therapy of colon carcinoma
Molecular Therapy 12: 1176-1184 (2005-09-29)
Keil C; Zeisig R; Fichtner I
Effect of surface modified liposomes on the aggregation of platelets and tumor cells
Thrombosis and Haemostasis 94 (2): 404-411 (2005-08)
Mravljak J; Zeisig R; Pecar S
Synthesis and biological evaluation of spin-labeled alkylphospholipid analogs
Journal of Medicinal Chemistry 48: 6393-6399 (2005-10-06)
Walther W; Stein U; Siegel R; Fichtner I; Schlag PM
Use of the nuclease inhibitor aurintricarboxylic acid (ATA) for improved non-viral intratumoral in vivo gene transfer by jet-injection
Journal of Gene Medicine 7: 477-485 (2005-01-01)
Becker M; Sommer A; Kraetzschmar JR; Seidel H; Pohlenz HD; Fichtner I
Distinct gene expression patterns in a tamoxifen-sensitive human mammary carcinoma xenograft and its tamoxifen-resistant subline MaCa 3366/TAM
Molecular Cancer Therapeutics 4: 151-170 (2005-01-01)
2004
Fichtner I; Becker M; Zeisig R; Sommer A
In vivo models for endocrine-dependent breast carcinomas: special considerations of clinical relevance
European Journal of Cancer 40: 845-851 (2004-01-01)
Zeisig R; Teppke AD; Behrens D; Fichtner I
Liposomal 4-hydroxy-tamoxifen: effect on cellular uptake and resulting cytotoxicity in drug resistant breast cancer cells in vitro
Breast Cancer Research and Treatment 87: 245-254 (2004-01-01)
Zeisig R; Stahn R; Wenzel K; Behrens D; Fichtner I
Effect of sialyl Lewis X-glycoliposomes on the inhibition of E-selectin-mediated tumour cell adhesion in vitro
Biochimica et Biophysica Acta - Biomembranes 1660: 31-40 (2004-01-01)
Fichtner I; Monks A; Hose C; Stevens MF; Bradshaw TD
The experimental antitumor agents phortress and doxorubicin are equiactive against human-derived breast carcinoma xenograft models
Breast Cancer Research and Treatment 87: 97-107 (2004-09-01)
Fichtner I; Slisow W; Gill J; Becker M; Elbe B; Hillebrand T; Bibby M
Anticancer drug response and expression of molecular markers in early-passage xenotransplanted colon carcinomas
European Journal of Cancer 40: 298-307 (2004-01-01)
2003
Fichtner I; Becker M; Baumgart J
Antileukaemic activity of treosulfan in xenografted human acute lymphoblastic leukaemias (ALL)
European Journal of Cancer 39: 801-807 (2003-01-01)
Erben U; Thiel E; Bittroff-Leben A; Schoch C; Fichtner I; Durkop H; Notter M
CS-1, a novel c-kithi+ acute myeloid leukemia cell line with dendritic cell differentiation capacity and absent immunogenicity
International Journal of Cancer 105 (2): 232-240 (2003-01-01)
Zeisig R; Ress A; Fichtner I; Walther W
Lipoplexes with alkylphospholipid as new helper lipid for efficient in vitro and in vivo gene transfer in tumor therapy
Cancer Gene Therapy 10: 302-311 (2003-01-01)
Nitsche A; Junghahn I; Thulke S; Aumann J; Radonic A; Fichtner I; Siegert W
Interleukin-3 promotes proliferation and differentiation of human hematopoietic stem cells but reduces their repopulation potential in NOD/SCID mice
Stem Cells 21: 236-244 (2003-01-01)
Dreier T; Baeuerle PA; Fichtner I; Gruen M; Schlereth B; Lorenczewski G; Kufer P; Lutterbuese R; Riethmueller G; Gjorstrup P; Bargou RC
T cell costimulus-independent and very efficacious inhibition of tumor growth in mice bearing subcutaneous or leukemic human B cell lymphoma xenografts by a CD19-/CD3-bispecific single-chain antibody construct1
Journal of Immunology 170 (8): 4397-4402 (2003-01-01)
Mansour AM; Drevs J; Esser N; Hamada FM; Badary OA; Unger C; Fichtner I; Kratz F
A new approach for the treatment of malignant melanoma: Enhanced antitumor efficacy of an albumin-binding doxorubicin prodrug that is cleaved by matrix metalloproteinase 2
Cancer Research 63: 4062-4066 (2003-01-01)
2002
Harder F; Henschler R; Junghahn I; Lamers MC; Mueller AM
Human hematopoiesis in murine embryos after injecting human cord blood-derived hematopoietic stem cells into murine blastocysts
Blood 99: 719-721 (2002-01-15)
Kratz F; Warnecke A; Scheuermann K; Stockmar C; Schwab J; Lazar P; Drueckes P; Esser N; Drevs J; Rognan D; Bissantz C; Hinderling C; Folkers G; Fichtner I; Unger C
Probing the cysteine-34 position of endogenous serum albumin with thiol-binding doxorubicin derivatives. Improved efficacy of an acid-sensitive doxorubicin derivative with specific albumin-binding properties compared to that of the parent compound
Journal of Medicinal Chemistry 45: 5523-5533 (2002-01-01)
Naundorf S; Preithner S; Mayer P; Lippold S; Wolf A; Hanakam F; Fichtner I; Kufer P; Raum T; Riethmueller G; Baeuerle PA; Dreier T
In vitro and in vivo activity of MT201, a fully human monoclonal antibody for pancarcinoma treatment
International Journal of Cancer 100: 101-110 (2002-07-01)
Becker M; Nitsche A; Neumann C; Aumann J; Junghahn I; Fichtner I
Sensitive PCR method for the detection and real-time quantification of human cells in xenotransplantation systems
British Journal of Cancer 87: 1328-1335 (2002-01-01)
Brunner N; Double J; Fichtner I; Gescher A; Newell D; Oosterhuis W; Price P
The EORTC Laboratory Research Division
European Journal of Cancer 38: S14-S18 (2002-01-01)
2001
Roemer I; Vogel T; Otto A; Fichtner I; Klose J
Analysis of mouse beta-haptoglobin chain by lectin affinoblotting detection
Electrophoresis 22: 3038-3042 (2001-01-01)
Walther W; Stein U; Fichtner I; Malcherek L; Lemm M; Schlag PM
Nonviral in vivo gene delivery into tumors using a novel low volume jet-injection technology
Gene Therapy 8: 173-180 (2001-01-01)
Nitsche A; Becker M; Junghahn I; Aumann J; Landt O; Fichtner I; Wittig B; Siegert W
Quantification of human cells in NOD/SCID mice by duplex real-time polymerase reaction
Haematologica 86: 693-699 (2001-01-01)
Stahn R; Grittner C; Zeisig R; Karsten U; Felix SB; Wenzel K
Sialyl Lewisx-liposomes as vehicles for site-directed, E-selectin-mediated drug transfer into activated endothelial cells
Cellular and Molecular Life Sciences 58: 141-147 (2001-01-01)
2000
Goan SR; Junghahn I; Wissler M; Becker M; Aumann J; Just U; Martiny-Baron G; Fichtner I; Henschler R
Donor stromal cells from human blood engraft in NOD/SCID mice
Blood 96: 3971-3978 (2000-12-01)
Walther W; Stein U; Fichtner I; Alexander M; Shoemaker RH; Schlag PM
mdr1 promoter-driven tumor necrosis factor-alpha expression for a chemotherapy-controllable combined in vivo gene therapy and chemotherapy of tumors
Cancer Gene Therapy 7: 893-900 (2000-06-01)
Naundorf H; Becker M; Lykkesfeldt AE; Elbe B; Neumann C; Buttner B; Fichtner I
Development and characterization of a tamoxifen resistant breast carcinoma xenograft
British Journal of Cancer 82: 1844-1850 (2000-06-01)
1999
Mrowietz U; Schwenk U; Maune S; Bartels J; Kuepper M; Fichtner I; Schroeder J-M; Schadendorf D
The chemokine RANTES is secreted by human melanoma cells and is associated with enhanced tumour formation in nude mice
British Journal of Cancer 79: 1025-1031 (1999-01-01)
Hoffmann J; Schmidt-Peter P; Haensch W; Naundorf H; Bunge A; Becker M; Fichtner I
Anticancer drug sensitivity and expression of multidrug resistance markers in early passage human sarcomas
Clinical Cancer Research 5: 2198-2204 (1999-08-01)
1998
Brachwitz H; Bergmann J; Fichtner I; Thomas Y; Vollgraf C; Langen P; Berdel WE
1-beta-D-Arabinofuranosylcytosine-5'-alkylphosphonophosphates and diphosphates: new orally active derivatives of ara-C
Journal of Lipid Research 39: 162-172 (1998-01-01)
Walther W; Stein U; Fichtner I; Naundorf H; Alexander M; Shoemaker RH; Schlag PM
In vivo evaluation of a drug-inducible vector system for the combined gene and chemotherapy of cancer
Cancer Gene Therapy : 139-144 (1998-01-01)
1997
Reszka R; Beck P; Fichtner I; Hentschel M; Richter J; Kreuter J
Body distribution of free, liposomal and nanoparticle-associated mitoxantrone in B16-melanoma-bearing mice
Journal of Pharmacology and Experimental Therapeutics 280: 232-237 (1997-01-01)
Stein U; Walther W; Lemm M; Naundorf H; Fichtner I
Development and characterization of novel human multidrug resistant mammary carcinoma lines in vitro and in vivo
International Journal of Cancer 72: 885-891 (1997-01-01)
1996
Shi DF; Bradshaw TD; Wrigley S; Mc Call CJ; Lelieveld P; Fichtner I; Stevens MFG
Antitumor benzothiazoles. 3.1Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo
Journal of Medicinal Chemistry 39: 3375-3384 (1996-01-01)
Stein U; Walther W; Shoemaker RH
Reversal of multidrug resistance by transduction of cytokine genes into human colon carcinoma cells
Journal of the National Cancer Institute 88: 1383-1392 (1996-01-01)
Schadendorf D; Kern MA; Artuc M; Pahl HL; Rosenbach T; Fichtner I; Nuernberg W; Stueting S; von Stebut E; Worm M; Makki A; Jurgovsky K; Kolde G; Henz BM
Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro, and causes growth inhibition in xenografts in vivo
Journal of Cell Biology 135 (6 Pt 2): 1889-1898 (1996-12)
Schadendorf D; Fichtner I; Makki A; Alijagic S; Kuepper M; Mrowietz U; Henz BM
Metastatic potential of human melanoma cells in nude mice - characterization of phenotype, cytokine secretion and tumour-associated antigens
British Journal of Cancer 74: 194-199 (1996-01-01)
Stein U; Walther W; Shoemaker H
Modulation of mdr1 expression by cytokines in human colon carcinoma cells: an approach for reversal of multidrug resistance
British Journal of Cancer 74: 1384-1391 (1996-01-01)
1995
Goan SR; Fichtner I; Just U; Karawajew L; Schultze W; Krause KP; von Harsdorf S; von Schilling C; Herrmann F
The severe combined immunodeficient-human peripheral blood stem cell (SCID-huPBSC) mouse: a xenotransplant model for huPBSC-initiated hematopoiesis
Blood 86 (1): 89-100 (1995-07-01)
Walther W; Stein U; Pfeil D
Gene transfer of human TNFalpha into glioblastoma cells permits modulation of mdr1 expression and potentiation of chemosensitivity
International Journal of Cancer 61 (6): 832-839 (1995-01-01)