Publications
2012
Frenzel H; Bohlender J; Pinsker K; Wohlleben B; Tank J; Lechner SG; Schiska D; Jaijo T; Rueschendorf F; Saar K; Jordan J; Millan JM; Gross M; Lewin GR
A genetic basis for mechanosensory traits in humans
PLoS Biology 10 (5): e1001318 (2012-05-01)
Doss MX; Gaspar JA; Winkler J; Hescheler J; Schulz H; Sachinidis A
Specific gene signatures and pathways in mesodermal cells and their derivatives derived from embryonic stem cells
Stem Cell Reviews and Reports 8 (1): 43-54 (2012-03)
Grosse J; Wehland M; Pietsch J; Ma X; Ulbrich C; Schulz H; Saar K; Huebner N; Hauslage J; Hemmersbach R; Braun M; van Loon J; Vagt N; Infanger M; Eilles C; Egli M; Richter P; Baltz T; Einspanier R; Sharbati S; Grimm D
Short-term weightlessness produced by parabolic flight maneuvers altered gene expression patterns in human endothelial cells
FASEB Journal 26 (2): 639-655 (2012-02)
Chakraborty D; Kappei D; Theis M; Nitzsche A; Ding L; Paszkowski-Rogacz M; Surendranath V; Berger N; Schulz H; Saar K; Hubner N; Buchholz F
Combined RNAi and localization for functionally dissecting long noncoding RNAs
Nature Methods 9 (4): 360-362 (2012-02-12)
Guo W; Schafer S; Greaser ML; Radke MH; Liss M; Govindarajan T; Maatz H; Schulz H; Li S; Parrish AM; Dauksaite V; Vakeel P; Klaassen S; Gerull B; Thierfelder L; Regitz-Zagrosek V; Hacker TA; Saupe KW; Dec GW; Ellinor PT; Macrae CA; Spallek B; Fischer R; Perrot A; Ozcelik C; Saar K; Hubner N; Gotthardt M
RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing
Nature Medicine : (2012-04-01)
Jackson M; Axton RA; Taylor AH; Wilson JA; Gordon-Keylock SA; Kokkaliaris K; Brickman JM; Schulz H; Hummel O; Hubner N; Forrester LM
HOXB4 can enhance the differentiation of embryonic stem cells by modulating the haematopoietic niche
Stem Cells 30 (2): 150-160 (2012-02)
Caglayan S; Bauerfeind A; Schmidt V; Carlo AS; Prabakaran T; Huebner N; Willnow TE
Identification of Alzheimer disease risk genotype that predicts efficiency of SORL1 expression in the brain
Archives of Neurology 69 (3): 373-379 (2012-03)
Leu C; de Kovel CG; Zara F; Striano P; Pezzella M; Robbiano A; Bianchi A; Bisulli F; Coppola A; Giallonardo AT; Beccaria F; Trenite DK; Lindhout D; Gaus V; Schmitz B; Janz D; Weber YG; Becker F; Lerche H; Kleefuss-Lie AA; Hallman K; Kunz WS; Elger CE; Muhle H; Stephani U; Moller RS; Hjalgrim H; Mullen S; Scheffer IE; Berkovic SF; Everett KV; Gardiner MR; Marini C; Guerrini R; Lehesjoki AE; Siren A; Nabbout R; Baulac S; Leguern E; Serratosa JM; Rosenow F; Feucht M; Unterberger I; Covanis A; Suls A; Weckhuysen S; Kaneva R; Caglayan H; Turkdogan D; Baykan B; Bebek N; Ozbek U; Hempelmann A; Schulz H; Rueschendorf F; Trucks H; Nuernberg P; Avanzini G; Koeleman BP; Sander T
Genome-wide linkage meta-analysis identifies susceptibility loci at 2q34 and 13q31.3 for genetic generalized epilepsies
Epilepsia 53 (2): 308-318 (2012-02)
Knuppel S; Esparza-Gordillo J; Marenholz I; Holzhutter H; Bauerfeind A; Ruether A; Weidinger S; Lee YA; Rohde K
Multi-locus stepwise regression: a haplotype-based algorithm for finding genetic associations applied to atopic dermatitis
BMC Medical Genetics 13 (1): 8 (2012-01-27)
2011
Marenholz I; Rivera VA; Esparza-Gordillo J; Bauerfeind A; Lee-Kirsch MA; Ciechanowicz A; Kurek M; Piskackova T; Macek M; Lee YA
Association screening in the epidermal differentiation complex (EDC) identifies an SPRR3 repeat number variant as a risk factor for eczema
Journal of Investigative Dermatology 131 (8): 1644-1649 (2011-08)
Stodola TJ; de Resende MM; Sarkis AB; Didier DN; Jacob HJ; Huebner N; Hummel O; Saar K; Moreno C; Greene AS
Characterization of the genomic structure and function of regions influencing renin and angiogenesis in the SS rat
Physiological Genomics 43 (13): 808-817 (2011-07-14)
Nitzsche A; Paszkowski-Rogacz M; Matarese F; Janssen-Megens EM; Hubner NC; Schulz H; de Vries I; Ding L; Huebner N; Mann M; Stunnenberg HG; Buchholz F
RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity
PLoS ONE 6 (5): e19470 (2011-05-12)
Charles RL; Burgoyne JR; Mayr M; Weldon SM; Hubner N; Dong H; Morisseau C; Hammock BD; Landar AL; Eaton P
Redox regulation of soluble epoxide hydrolase by 15-deoxy-{delta}-prostaglandin J2 controls coronary hypoxic vasodilation
Circulation Research 108 (3): 324-334 (2011-02-04)
Marenholz I; Bauerfeind A; Esparza-Gordillo J; Kerscher T; Granell R; Nickel R; Lau S; Henderson J; Lee YA
The eczema risk variant on chromosome 11q13 (rs7927894) in the population-based ALSPAC cohort: a novel susceptibility factor for asthma and hay fever
Human Molecular Genetics 20 (12): 2443-2449 (2011-06-15)
Morrissey C; Grieve IC; Heinig M; Atanur S; Petretto E; Pravenec M; Hubner N; Aitman TJ
Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat
Physiological Genomics 43 (21): 1207-1218 (2011-11-07)
McDermott-Roe C; Ye J; Ahmed R; Sun XM; Serafin A; Ware J; Bottolo L; Muckett P; Canas X; Zhang J; Rowe GC; Buchan R; Lu H; Braithwaite A; Mancini M; Hauton D; Marti R; Garcia-Arumi E; Hubner N; Jacob H; Serikawa T; Zidek V; Papousek F; Kolar F; Cardona M; Ruiz-Meana M; Garcia-Dorado D; Comella JX; Felkin LE; Barton PJ; Arany Z; Pravenec M; Petretto E; Sanchis D; Cook SA
Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function
Nature 478 (7367): 114-118 (2011-10-06)
Ulbrich C; Pietsch J; Grosse J; Wehland M; Schulz H; Saar K; Huebner N; Hauslage J; Hemmersbach R; Braun M; van Loon J; Vagt N; Egli M; Richter P; Einspanier R; Sharbati S; Baltz T; Infanger M; Ma X; Grimm D
Differential gene regulation under altered gravity conditions in follicular thyroid cancer cells: relationship between the extracellular matrix and the cytoskeleton
Cellular Physiology and Biochemistry 28 (2): 185-198 (2011-08-16)
Blaydon DC; Biancheri P; Di WL; Plagnol V; Cabral RM; Brooke MA; van Heel DA; Ruschendorf F; Toynbee M; Walne A; O'Toole EA; Martin JE; Lindley K; Vulliamy T; Abrams DJ; MacDonald TT; Harper JI; Kelsell DP
Inflammatory skin and bowel disease linked to ADAM17 deletion
New England Journal of Medicine 365 (16): 1502-1508 (2011-10-20)
Wenzel K; Rajakumar A; Haase H; Geusens N; Hubner N; Schulz H; Brewer J; Roberts L; Hubel CA; Herse F; Hering L; Qadri F; Lindschau C; Wallukat G; Pijnenborg R; Heidecke H; Riemekasten G; Luft FC; Muller DN; Lamarca B; Dechend R
Angiotensin II type 1 receptor antibodies and increased angiotensin II sensitivity in pregnant rats
Hypertension 58 (1): 77-84 (2011-07)
2010
Stellzig-Eisenhauer A; Decker E; Meyer-Marcotty P; Rau C; Fiebig BS; Kress W; Saar K; Rueschendorf F; Huebner N; Grimm T; Witt E; Weber BH
Primary failure of eruption (PFE) - clinical and molecular genetics analysis
Journal of Orofacial Orthopedics 71 (1): 6-16 (2010-01)
Gong M; Rueschendorf F; Marx P; Schulz H; Kraft HG; Huebner N; Koennecke HC
Clinical and genetic features in a family with CADASIL and high lipoprotein (a) values
Journal of Neurology 257 (8): 1240-1245 (2010-08)
de Kovel CG; Pinto D; Tauer U; Lorenz S; Muhle H; Leu C; Neubauer BA; Hempelmann A; Callenbach PM; Scheffer IE; Berkovic SF; Rudolf G; Striano P; Siren A; Baykan B; Sander T; Lindhout D; Kasteleijn-Nolst Trenite DG; Stephani U; Koeleman BP
Whole-genome linkage scan for epilepsy-related photosensitivity: a mega-analysis
Epilepsy Research 89 (2-3): 286-294 (2010-05)
Manke T; Heinig M; Vingron M
Quantifying the effect of sequence variation on regulatory interactions
Human Mutation 31 (4): 477-483 (2010-04)
Joutel A; Monet-Lepretre M; Gosele C; Baron-Menguy C; Hammes A; Schmidt S; Lemaire-Carrette B; Domenga V; Schedl A; Lacombe P; Huebner N
Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease
Journal of Clinical Investigation 120 (2): 433-445 (2010-02-01)
Heinig M; Petretto E; Wallace C; Bottolo L; Rotival M; Lu H; Li Y; Sarwar R; Langley SR; Bauerfeind A; Hummel O; Lee YA; Paskas S; Rintisch C; Saar K; Cooper J; Buchan R; Gray EE; Cyster JG; Braund P; Gracey J; Krishnan U; Moore JS; Nelson CP; Pollard H; Attwood T; Crisp-Hihn A; Foad N; Jolley J; Lloyd-Jones H; Muir D; Murray E; O'Leary K; Rankin A; Sambrook J; Godfroy T; Brocheton J; Proust C; Schmitz G; Heimerl S; Lugauer I; Belz S; Gulde S; Linsel-Nitschke P; Sager H; Schroeder L; Lundmark P; Syvannen AC; Neudert J; Scholz M; Deloukas P; Gray E; Gwilliams R; Niblett D; Erdmann J; Hengstenberg C; Maouche S; Ouwehand WH; Rice CM; Samani NJ; Schunkert H; Goodall AH; Schulz H; Roider HG; Vingron M; Blankenberg S; Muenzel T; Zeller T; Szymczak S; Ziegler A; Tiret L; Smyth DJ; Pravenec M; Aitman TJ; Cambien F; Clayton D; Todd JA; Huebner N; Cook SA
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk
Nature 467 (7314): 460-464 (2010-09-23)
Jirout ML; Friese RS; Mahapatra NR; Mahata M; Taupenot L; Mahata SK; Kren V; Zidek V; Fischer J; Maatz H; Ziegler MG; Pravenec M; Huebner N; Aitman TJ; Schork NJ; O'Connor DT
Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat
Human Molecular Genetics 19 (13): 2567-2580 (2010-07-01)
Ratelade J; Arrondel C; Hamard G; Garbay S; Harvey S; Biebuyck N; Schulz H; Hastie N; Pontoglio M; Gubler MC; Antignac C; Heidet L
A murine model of Denys-Drash syndrome reveals novel transcriptional targets of WT1 in podocytes
Human Molecular Genetics 19 (1): 1-15 (2010-01-01)
Doss MX; Wagh V; Schulz H; Kull M; Kolde R; Pfannkuche K; Nolden T; Himmelbauer H; Vilo J; Hescheler J; Sachinidis A
Global transcriptomic analysis of murine embryonic stem cell-derived brachyury+ (T) cells
Genes to Cells 15 (3): 209-228 (2010-03)
Wenzel K; Wallukat G; Qadri F; Huebner N; Schulz H; Hummel O; Herse F; Heuser A; Fischer R; Heidecke H; Luft FC; Mueller DN; Dietz R; Dechend R
alpha(1A)-adrenergic receptor-directed autoimmunity induces left ventricular damage and diastolic dysfunction in rats
PLoS ONE 5 (2): e9409 (2010-02-24)
Reutter H; Rueschendorf F; Mattheisen M; Draaken M; Bartels E; Huebner N; Hoffmann P; Payabvash S; Saar K; Noethen MM; Kajbafzadeh AM; Ludwig M
Evidence for linkage of the bladder exstrophy-epispadias complex on chromosome 4q31.21-22 and 19q13.31-41 from a consanguineous iranian family
Birth Defects Research. Part A, Clinical and Molecular Teratology 88 (9): 757-761 (2010-09)
Popovic M; Paskas S; Zivkovic M; Burysek L; Laumonnier Y
Human cytomegalovirus increases HUVEC sensitivity to thrombin and modulates expression of thrombin receptors
Journal of Thrombosis and Thrombolysis 30 (2): 164-171 (2010-08)
Reese J; Kraschewski A; Anghelescu I; Winterer G; Schmidt LG; Gallinat J; Rueschendorf F; Rommelspacher H; Wernicke C
Haplotypes of dopamine and serotonin transporter genes are associated with antisocial personality disorder in alcoholics
Psychiatric Genetics 20 (4): 140-152 (2010-08)
Atanur SS; Birol I; Guryev V; Hirst M; Hummel O; Morrissey C; Behmoaras J; Fernandez-Suarez XM; Johnson MD; McLaren WM; Patone G; Petretto E; Plessy C; Rockland KS; Rockland C; Saar K; Zhao Y; Carninci P; Flicek P; Kurtz T; Cuppen E; Pravenec M; Huebner N; Jones SJ; Birney E; Aitman TJ
The genome sequence of the spontaneously hypertensive rat: analysis and functional significance
Genome Research 20 (6): 791-803 (2010-06)
Petretto E; Bottolo L; Langley SR; Heinig M; McDermott-Roe C; Sarwar R; Pravenec M; Huebner N; Aitman TJ; Cook SA; Richardson S
New insights into the genetic control of gene expression using a Bayesian multi-tissue approach
PLoS Computational Biology 6 (4): e1000737 (2010-04-08)
Yagil Y; Hessner MJ; Schulz H; Gosele C; Lebdev L; Barkalifa R; Sapojnikov M; Huebner N; Yagil C
Geno-transcriptomic dissection of proteinuria in the uninephrectomized rat uncovers a molecular complexity with sexual dimorphism
Physiological Genomics 42A (4): 301-316 (2010-11-29)
Rolletschek A; Schroeder IS; Schulz H; Hummel O; Huebner N; Wobus AM
Characterization of mouse embryonic stem cell differentiation into the pancreatic lineage in vitro by transcriptional profiling, quantitative RT-PCR and immunocytochemistry
International Journal of Developmental Biology 54 (1): 41-54 (2010)
Zeller T; Wild P; Szymczak S; Rotival M; Schillert A; Castagne R; Maouche S; Germain M; Lackner K; Rossmann H; Eleftheriadis M; Sinning CR; Schnabel RB; Lubos E; Mennerich D; Rust W; Perret C; Proust C; Nicaud V; Loscalzo J; Huebner N; Tregouet D; Muenzel T; Ziegler A; Tiret L; Blankenberg S; Cambien F
Genetics and beyond - the transcriptome of human monocytes and disease susceptibility
PLoS ONE 5 (5): e10693 (2010)
Liska F; Snajdr P; Stricker S; Goesele C; Krenova D; Mundlos S; Huebner N
Impairment of sox9 expression in limb buds of rats homozygous for hypodactyly mutation
Folia Biologica Prague 56 (2): 58-65 (2010)
Christ A; Terryn S; Schmidt V; Christensen EI; Huska MR; Andrade-Navarro MA; Huebner N; Devuyst O; Hammes A; Willnow TE
The soluble intracellular domain of megalin does not affect renal proximal tubular function in vivo
Kidney International 78 (5): 473-477 (2010-09)
Toka O; Maass PG; Aydin A; Toka H; Huebner N; Rueschendorf F; Gong M; Luft FC; Baehring S
Childhood hypertension in autosomal-dominant hypertension with brachydactyly
Hypertension 56 (5): 988-994 (2010-11)
Wang Y; Liska F; Gosele C; Sedova L; Kren V; Krenova D; Ivics Z; Huebner N; Izsvak Z
A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains
Genome Research 20 (1): 19-27 (2010-01)
2009
Tabakoff B; Saba L; Printz M; Flodman P; Hodgkinson C; Goldman D; Koob G; Richardson HN; Kechris K; Bell RL; Huebner N; Heinig M; Pravenec M; Mangion J; Legault L; Dongier M; Conigrave KM; Whitfield JB; Saunders J; Grant B; Hoffman PL
Genetical genomic determinants of alcohol consumption in rats and humans
BMC Biology 7 (1): 70 (2009-10-27)
Potta SP; Liang H; Pfannkuche K; Winkler J; Chen S; Doss MX; Obernier K; Kamisetti N; Schulz H; Huebner N; Hescheler J; Sachinidis A
Functional characterization and transcriptome analysis of embryonic stem cell-derived contractile smooth muscle cells
Hypertension 53 (2): 196-204 (2009-02)
Henneke M; Diekmann S; Ohlenbusch A; Kaiser J; Engelbrecht V; Kohlschuetter A; Kraetzner R; Madruga-Garrido M; Mayer M; Opitz L; Rodriguez D; Rueschendorf F; Schumacher J; Thiele H; Thoms S; Steinfeld R; Nuernberg P; Gaertner J
RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection
Nature Genetics 41 (7): 773-775 (2009-07)
Storm MP; Kumpfmueller B; Thompson B; Kolde R; Vilo J; Hummel O; Schulz H; Welham MJ
Characterization of the phosphoinositide 3-kinase-dependent transcriptome in murine embryonic stem cells: identification of novel regulators of pluripotency
Stem Cells 27 (4): 764-775 (2009-04)
Popovic M; Paskas S; Zivkovic M; Duric-Delic T; Stankovic A; Burysek L
In HCMV-exposed HUVEC, P52/RelB regulatory factors mediate activation of the human PAR1 gene promoter
Archives of Biological Sciences 61 (4): 613-618 (2009)
Bourillot PY; Aksoy I; Schreiber V; Wianny F; Schulz H; Hummel O; Huebner N; Savatier P
Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog
Stem Cells 27 (8): 1760-1771 (2009-08)
Buschmann EE; Utz W; Pagonas N; Schulz-Menger J; Busjahn A; Monti J; Maerz W; Le Noble F; Thierfelder L; Dietz R; Klauss V; Gross M; Buschmann IR
Improvement of fractional flow reserve and collateral flow by treatment with external counterpulsation (Art.Net.-2 Trial)
European Journal of Clinical Investigation 39 (10): 866-875 (2009-10)
Beier KC; Humberdros S; Witt H; Illi S; Rueschendorf F; Nickel R; Lee YA; Lau S; Wahn U; Hamelmann E
ICOS-gene variants are not associated with atopic disease susceptibility in European children
Pediatric Allergy and Immunology 20 (3): 242-245 (2009-05)
Mollet G; Ratelade J; Boyer O; Muda AO; Morisset L; Lavin TA; Kitzis D; Dallman MJ; Bugeon L; Huebner N; Gubler MC; Antignac C; Esquivel EL
Podocin inactivation in mature kidneys causes focal segmental glomerulosclerosis and nephrotic syndrome
Journal of the American Society of Nephrology 20 (10): 2181-2189 (2009-08-27)
Huck K; Feyen O; Niehues T; Rueschendorf F; Huebner N; Laws HJ; Telieps T; Knapp S; Wacker HH; Meindl A; Jumaa H; Borkhardt A
Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation
Journal of Clinical Investigation 119 (5): 1350-1358 (2009-05)
Helbig I; Mefford HC; Sharp AJ; Guipponi M; Fichera M; Franke A; Muhle H; de Kovel C; Baker C; von Spiczak S; Kron KL; Steinich I; Kleefuss-Lie AA; Leu C; Gaus V; Schmitz B; Klein KM; Reif PS; Rosenow F; Weber Y; Lerche H; Zimprich F; Urak L; Fuchs K; Feucht M; Genton P; Thomas P; Visscher F; de Haan GJ; Moller RS; Hjalgrim H; Luciano D; Wittig M; Nothnagel M; Elger CE; Nuernberg P; Romano C; Malafosse A; Koeleman BP; Lindhout D; Stephani U; Schreiber S; Eichler EE; Sander T
15q13.3 microdeletions increase risk of idiopathic generalized epilepsy
Nature Genetics 41 (2): 160-162 (2009-02)
Vogel H; Nestler M; Rueschendorf F; Block MD; Tischer S; Kluge R; Schurmann A; Joost HG; Scherneck S
Characterization of Nob3, a major quantitative trait locus for obesity and hyperglycemia on mouse chromosome 1
Physiological Genomics 38 (2): 226-232 (2009-07-09)
Mariappan D; Winkler J; Chen S; Schulz H; Hescheler J; Sachinidis A
Transcriptional profiling of CD31(+) cells isolated from murine embryonic stem cells
Genes to Cells 14 (2): 243-260 (2009-02)
Mariappan D; Niemann R; Gajewski M; Winkler J; Chen S; Choorapoikayil S; Bitzer M; Schulz H; Hescheler J; Sachinidis A
Somitovasculin, a novel endothelial-specific transcript involved in the vasculature development
Arteriosclerosis Thrombosis and Vascular Biology 29 (11): 1823-1829 (2009-11)
Lebrun AH; Storch S; Rueschendorf F; Schmiedt ML; Kyttaelae A; Mole SE; Kitzmueller C; Saar K; Mewasingh LD; Boda V; Kohlschuetter A; Ullrich K; Braulke T; Schulz A
Retention of lysosomal protein CLN5 in the endoplasmic reticulum causes neuronal ceroid lipofuscinosis in Asian Sibship
Human Mutation 30 (5): E651-E661 (2009-03-23)
Neuhaus AH; Opgen-Rhein C; Urbanek C; Hahn E; Ta TM; Seidelsohn M; Strathmann S; Kley F; Wieseke N; Sander T; Dettling M
COMT Val 158 Met polymorphism is associated with cognitive flexibility in a signal discrimination task in schizophrenia
Pharmacopsychiatry 42 (4): 141-144 (2009-07)
Trouillas M; Saucourt C; Guillotin B; Gauthereau X; Ding L; Buchholz F; Doss MX; Sachinidis A; Hescheler J; Hummel O; Huebner N; Kolde R; Vilo J; Schultz H; Boeuf H
Three LIF-dependent signatures and gene clusters with atypical expression profiles, identified by transcriptome studies in mouse ES cells and early derivatives
BMC Genomics 10 (1): 73 (2009-02-09)
Heinz-Erian P; Mueller T; Krabichler B; Schranz M; Becker C; Rueschendorf F; Nuernberg P; Rossier B; Vujic M; Booth IW; Holmberg C; Wijmenga C; Grigelioniene G; Kneepkens CM; Rosipal S; Mistrik M; Kappler M; Michaud L; Doczy LC; Siu VM; Krantz M; Zoller H; Utermann G; Janecke AR
Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea
American Journal of Human Genetics 84 (2): 188-196 (2009-02)
Schulz H; Kolde R; Adler P; Aksoy I; Anastassiadis K; Bader M; Billon N; Boeuf H; Bourillot PY; Buchholz F; Dani C; Doss MX; Forrester L; Gitton M; Henrique D; Hescheler J; Himmelbauer H; Huebner N; Karantzali E; Kretsovali A; Lubitz S; Pradier L; Rai M; Reimand J; Rolletschek A; Sachinidis A; Savatier P; Stewart F; Storm MP; Trouillas M; Vilo J; Welham MJ; Winkler J; Wobus AM; Hatzopoulos AK
The FunGenES database: a genomics resource for mouse embryonic stem cell differentiation
PLoS ONE 4 (9): e6804 (2009)
Marenholz I; Kerscher T; Bauerfeind A; Esparza-Gordillo J; Nickel R; Keil T; Lau S; Rohde K; Wahn U; Lee YA
An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma
Journal of Allergy and Clinical Immunology 123 (4): 911-916 (2009-04)
Esparza-Gordillo J; Weidinger S; Foelster-Holst R; Bauerfeind A; Rueschendorf F; Patone G; Rohde K; Marenholz I; Schulz F; Kerscher T; Huebner N; Wahn U; Schreiber S; Franke A; Vogler R; Heath S; Baurecht H; Novak N; Rodriguez E; Illig T; Lee-Kirsch MA; Ciechanowicz A; Kurek M; Piskackova T; Macek M; Lee YA; Ruether A
A common variant on chromosome 11q13 is associated with atopic dermatitis
Nature Genetics 41 (5): 596-601 (2009-05)
Kleefuss-Lie A; Friedl W; Cichon S; Haug K; Warnstedt M; Alekov A; Sander T; Ramirez A; Poser B; Maljevic S; Hebeisen S; Kubisch C; Rebstock J; Horvath S; Hallmann K; Dullinger JS; Rau B; Haverkamp F; Beyenburg S; Schulz H; Janz D; Giese B; Muller-Newen G; Propping P; Elger CE; Fahlke C; Lerche H
CLCN2 variants in idiopathic generalized epilepsy
Nature Genetics 41 (9): 954-955 (2009-09)
Hildebrandt F; Heeringa SF; Rueschendorf F; Attanasio M; Nuernberg G; Becker C; Seelow D; Huebner N; Chernin G; Vlangos CN; Zhou W; O'Toole JF; Hoskins BE; Wolf MT; Hinkes BG; Chaib H; Ashraf S; Allen SJ; Vega-Warner V; Wise E; Harville HM; Lyons RH; Washburn J; Macdonald J; Nuernberg P; Otto EA
A systematic approach to mapping recessive disease genes in individuals from outbred populations
PLoS Genetics 5 (1): e1000353 (2009-01)
Hoffmann K; Planitz C; Rueschendorf F; Mueller-Myhsok B; Stassen HH; Lucke B; Mattheisen M; Stumvoll M; Bochmann R; Zschornack M; Wienker TF; Nuernberg P; Reis A; Luft FC; Lindner TH
A novel locus for arterial hypertension on chromosome 1p36 maps to a metabolic syndrome trait cluster in the Sorbs, a Slavic population isolate in Germany*
Journal of Hypertension 27 (5): 983-990 (2009-05)
Zitnik SE; Rueschendorf F; Mueller S; Sengler C; Lee YA; Griffioen RW; Meglio P; Wahn U; Witt H; Nickel R
IL13 variants are associated with total serum IgE and early sensitization to food allergens in children with atopic dermatitis
Pediatric Allergy and Immunology 20 (6): 551-555 (2009-09)
Ding L; Paszkowski-Rogacz M; Nitzsche A; Slabicki MM; Heninger AK; Vries ID; Kittler R; Junqueira M; Shevchenko A; Schulz H; Huebner N; Doss MX; Sachinidis A; Hescheler J; Iacone R; Anastassiadis K; Stewart AF; Pisabarro MT; Caldarelli A; Poser I; Theis M; Buchholz F
A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity
Cell Stem Cell 4 (5): 403-415 (2009-05-08)
Fisher E; Stefan N; Saar K; Drogan D; Schulze MB; Fritsche A; Joost HG; Haering HU; Huebner N; Boeing H; Weikert C
Association of AHSG gene polymorphisms with fetuin-A plasma levels and cardiovascular diseases in the EPIC-Potsdam study
Circulation Cardiovascular Genetics 2 (6): 607-613 (2009-12)
Ludwig M; Rueschendorf F; Saar K; Huebner N; Siekmann L; Boyadjiev SA; Reutter H
Genome-wide linkage scan for bladder exstrophy-epispadias complex
Birth Defects Research A 85 (2): 174-8 (2009-02)
Liska F; Goesele C; Rivkin E; Tres L; Cardoso MC; Domaing P; Krejci E; Snajdr P; Lee-Kirsch MA; de Rooij DG; Kren V; Krenova D; Kierszenbaum AL; Huebner N
Rat hd mutation reveals an essential role of centrobin in spermatid head shaping and assembly of the head-tail coupling apparatus
Biology of Reproduction 81 (6): 1196-1205 (2009-12)
2008
Gilibert S; Kwitek AE; Huebner N; Tschannen M; Jacob HJ; Sassard J; Bataillard AP
The effects of chromosome 17 on features of the metabolic syndrome in the Lyon Hypertensive (LH) rat
Physiological Genomics 33 (2): 212-217 (2008-04-22)
Schmack K; Schlagenhauf F; Sterzer P; Wrase J; Beck A; Dembler T; Kalus P; Puls I; Sander T; Heinz A; Gallinat J
Catechol-O-methyltransferase val158met genotype influences neural processing of reward anticipation
NeuroImage 42 (4): 1631-1638 (2008-10-01)
Decker E; Stellzig-Eisenhauer A; Fiebig BS; Rau C; Kress W; Saar K; Rueschendorf F; Huebner N; Grimm T; Weber BH
PTHR1 loss-of-function mutations in familial, nonsyndromic primary failure of tooth eruption
American Journal of Human Genetics 83 (6): 781-786 (2008-12)
Wenzel K; Haase H; Wallukat G; Derer W; Bartel S; Homuth V; Herse F; Huebner N; Schulz H; Janczikowski M; Lindschau C; Schroeder C; Verlohren S; Morano I; Mueller DN; Luft FC; Dietz R; Dechend R; Karczewski P
Potential relevance of alpha(1)-adrenergic receptor autoantibodies in refractory hypertension
PLoS ONE 3 (11): e3742 (2008)
Opgen-Rhein C; Neuhaus AH; Urbanek C; Hahn E; Sander T; Dettling M
Executive attention in schizophrenic males and the impact of COMT Val108/158Met genotype on performance on the Attention Network Test
Schizophrenia Bulletin 34 (6): 1231-1239 (2008-11)
Petretto E; Sarwar R; Grieve I; Lu H; Kumaran MK; Muckett PJ; Mangion J; Schroen B; Benson M; Punjabi PP; Prasad SK; Pennell DJ; Kiesewetter C; Tasheva ES; Corpuz LM; Webb MD; Conrad GW; Kurtz TW; Kren V; Fischer J; Huebner N; Pinto YM; Pravenec M; Aitman TJ; Cook SA
Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass
Nature Genetics 40 (5): 546-552 (2008-04-28)
Guryev V; Saar K; Adamovic T; Verheul M; van Heesch SA; Cook S; Pravenec M; Aitman T; Jacob H; Shull JD; Huebner N; Cuppen E
Distribution and functional impact of DNA copy number variation in the rat
Nature Genetics 40 (5): 538-545 (2008-04-28)
Puk O; Loester J; Dalke C; Soewarto D; Fuchs H; Budde B; Nuernberg P; Wolf E; de Angelis MH; Graw J
Mutation in a novel connexin-like gene (Gjf1) in the mouse affects early lens development and causes a variable small-eye phenotype
Investigative Ophthalmology & Visual Science 49 (4): 1525-1532 (2008-04)
Monti J; Fischer J; Paskas S; Heinig M; Schulz H; Goesele C; Heuser A; Fischer R; Schmidt C; Schirdewan A; Gross V; Hummel O; Maatz H; Patone G; Saar K; Vingron M; Weldon SM; Lindpaintner K; Hammock BD; Rohde K; Dietz R; Cook SA; Schunck WH; Luft FC; Huebner N
Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease
Nature Genetics 40 (5): 529-537 (2008-05)
Grieve IC; Dickens NJ; Pravenec M; Kren V; Huebner N; Cook SA; Aitman TJ; Petretto E; Mangion J
Genome-wide co-expression analysis in multiple tissues
PLoS ONE 3 (12): e4033 (2008)
Karantzali E; Schulz H; Hummel O; Huebner N; Hatzopoulos A; Kretsovali A
Histone deacetylase inhibition accelerates the early events of stem cell differentiation: transcriptomic and epigenetic analysis
Genome Biology 9 (4): R65 (2008-04-04)
Ratelade J; Lavin TA; Muda AO; Morisset L; Mollet G; Boyer O; Chen DS; Henger A; Kretzler M; Huebner N; Thery C; Gubler MC; Montagutelli X; Antignac C; Esquivel EL
Maternal environment interacts with modifier genes to influence progression of nephrotic syndrome
Journal of the American Society of Nephrology 19 (8): 1491-1499 (2008-08)
Lohoff FW; Lautenschlager M; Mohr J; Ferraro TN; Sander T; Gallinat J
Association between variation in the vesicular monoamine transporter 1 gene on chromosome 8p and anxiety-related personality traits
Neuroscience Letters 434 (1): 41-45 (2008-03-21)
Pasternack SM; von Kuegelgen I; Aboud KA; Lee YA; Rueschendorf F; Voss K; Hillmer AM; Molderings GJ; Franz T; Ramirez A; Nuernberg P; Noethen MM; Betz RC
G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth
Nature Genetics 40 (3): 329-334 (2008-02-24)
Aitman TJ; Critser JK; Cuppen E; Dominiczak A; Fernandez-Suarez XM; Flint J; Gauguier D; Geurts AM; Gould M; Harris PC; Holmdahl R; Huebner N; Izsvak Z; Jacob HJ; Kuramoto T; Kwitek AE; Marrone A; Mashimo T; Moreno C; Mullins J; Mullins L; Olsson T; Pravenec M; Riley L; Saar K; Serikawa T; Shull JD; Szpirer C; Twigger SN; Voigt B; Worley K
Progress and prospects in rat genetics: a community view
Nature Genetics 40 (5): 516-22 (2008-04-28)
Saar K; Beck A; Bihoreau MT; Birney E; Brocklebank D; Chen Y; Cuppen E; Demonchy S; Dopazo J; Flicek P; Foglio M; Fujiyama A; Gut IG; Gauguier D; Guigo R; Guryev V; Heinig M; Hummel O; Jahn N; Klages S; Kren V; Kube M; Kuhl H; Kuramoto T; Kuroki Y; Lechner D; Lee YA; Lopez-Bigas N; Lathrop GM; Mashimo T; Medina I; Mott R; Patone G; Perrier-Cornet JA; Platzer M; Pravenec M; Reinhardt R; Sakaki Y; Schilhabel M; Schulz H; Serikawa T; Shikhagaie M; Tatsumoto S; Taudien S; Toyoda A; Voigt B; Zelenika D; Zimdahl H; Huebner N
SNP and haplotype mapping for genetic analysis in the rat
Nature Genetics 40 (5): 560-566 (2008-04-28)
Ackermann GE; Domenighetti AA; Deten A; Bonath I; Marenholz I; Pedrazzini T; Erne P; Heizmann CW
S100A1 deficiency results in prolonged ventricular repolarization in response to sympathetic activation
General Physiology and Biophysics 27 (2): 127-142 (2008-06)
Tang B; Sander T; Craven KB; Hempelmann A; Escayg A
Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy
Neurobiology of Diseases 29 (1): 59-70 (2008-01)
Kota LT; Schulz H; Falak S; Huebner N; Osborne-Pellegrin M
Localization of genetic loci controlling hydronephrosis in the Brown Norway rat and its association with hematuria
Physiological Genomics 34 (2): 215-224 (2008-07-15)
Pravenec M; Churchill PC; Churchill MC; Viklicky O; Kazdova L; Aitman TJ; Petretto E; Huebner N; Wallace CA; Zimdahl H; Zidek V; Landa V; Dunbar J; Bidani A; Griffin K; Qi N; Maxova M; Kren V; Mlejnek P; Wang J; Kurtz TW
Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension
Nature Genetics 40 (8): 952-954 (2008-08)
Maerschenz S; Brinckmann A; Nuernberg P; Krueger DH; Guenther S; Meisel H
Co-replication analyses of naturally occurring defective hepatitis B virus variants with wild-type
Virology 372 (2): 247-259 (2008-03-15)
Kayser M; Lao O; Saar K; Brauer S; Wang X; Nuernberg P; Trent RJ; Stoneking M
Genome-wide analysis indicates more Asian than Melanesian ancestry of Polynesians
American Journal of Human Genetics 82 (1): 194-198 (2008-01)
Gotthardt D; Runz H; Keitel V; Fischer C; Flechtenmacher C; Wirtenberger M; Weiss KH; Imparato S; Braun A; Hemminki K; Stremmel W; Rueschendorf F; Stiehl A; Kubitz R; Burwinkel B; Schirmacher P; Knisely AS; Zschocke J; Sauer P
A mutation in the canalicular phospholipid transporter gene, ABCB4, is associated with cholestasis, ductopenia, and cirrhosis in adults
Hepatology 48 (4): 1157-1166 (2008-10)
Leistner S; Huebner N; Faulstich A; Ludwig D; Rees M; Marx P; Langer B; Nikolova A; Hartmann A; Koennecke HC
Increased prevalence of microangiopathic brain lesions among siblings of patients with lacunar stroke. A prospective multicenter study
European Neurology 59 (3-4): 143-147 (2008-04)
2007
Wenzel K; Daskalow K; Herse F; Seitz S; Zacharias U; Schenk JA; Schulz H; Huebner N; Micheel B; Schlag PM; Osterziel KJ; Ozcelik C; Scherneck S; Jandrig B
Expression of the protein phosphatase 1 inhibitor KEPI is downregulated in breast cancer cell lines and tissues and involved in the regulation of the tumor suppressor EGR1 via the MEK-ERK pathway
Biological Chemistry 388 (5): 489-495 (2007-05)
Lang UE; Bajbouj M; Sander T; Gallinat J
Gender-dependent association of the functional catechol-O-methyltransferase Val158Met genotype with sensation seeking personality trait
Neuropsychopharmacology 32: 1950-1955 (2007-02-14)
Wenzel K; Geier C; Qadri F; Huebner N; Schulz H; Erdmann B; Gross V; Bauer D; Dechend R; Dietz R; Osterziel KJ; Spuler S; Oezcelik C
Dysfunction of dysferlin-deficient hearts
Journal of Molecular Medicine 85 (11): 1203-1214 (2007-11)
Kota L; Osborne-Pellegrin M; Schulz H; Behmoaras J; Coutard M; Gong M; Huebner N
Quantitative genetic basis of arterial phenotypes in the Brown Norway rat
Physiological Genomics 30 (1): 17-25 (2007-06-19)
Everett KV; Chioza B; Aicardi J; Aschauer H; Brouwer O; Callenbach P; Covanis A; Dulac O; Eeg-Olofsson O; Feucht M; Friis M; Goutieres F; Guerrini R; Heils A; Kjeldsen M; Lehesjoki AE; Makoff A; Nabbout R; Olsson I; Sander T; Siren A; McKeigue P; Robinson R; Taske N; Rees M; Gardiner M
Linkage and association analysis of CACNG3 in childhood absence epilepsy
European Journal of Human Genetics 15(4): 463-472 (2007-04-01)
Gallinat J; Goetz T; Kalus P; Bajbouj M; Sander T; Winterer G
Genetic variations of the NR3A subunit of the NMDA receptor modulate prefrontal cerebral activity in humans
Journal of Cognitive Neuroscience 19 (1): 59-68 (2007-01)
Hoyer J; Dreweke A; Becker C; Gohring I; Thiel CT; Peippo MM; Rauch R; Hofbeck M; Trautmann U; Zweier C; Zenker M; Huffmeier U; Kraus C; Ekici AB; Ruschendorf F; Nurnberg P; Reis A; Rauch A
Molecular karyotyping in patients with mental retardation using 100 K SNP arrays
Journal of Medical Genetics 44 (10): 629-636 (2007-10)
Gregory-Evans CY; Moosajee M; Hodges MD; Mackay DS; Game L; Vargesson N; Bloch-Zupan A; Rueschendorf F; Santos-Pinto L; Wackens G; Gregory-Evans K
SNP genome scanning localises oto-dental syndrome to chromosome 11q13 and microdeletions at this locus implicate FGF3 in dental and inner ear disease and FADD in ocular coloboma
Human Molecular Genetics 16 (20): 3482-3493 (2007-10-15)
Lee-Kirsch MA; Chowdhury D; Harvey S; Gong M; Senenko L; Engel K; Pfeiffer C; Hollis T; Gahr M; Perrino FW; Lieberman J; Huebner N
A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus
Journal of Molecular Medicine 85 (5): 531-537 (2007-05)
Doss MX; Winkler J; Chen S; Hippler-Altenburg R; Sotiriadou I; Halbach M; Pfannkuche K; Liang H; Schulz H; Hummel O; Huebner N; Rottscheidt R; Hescheler J; Sachinidis A
Global transcriptome analysis of murine embryonic stem cell-derived cardiomyocytes
Genome Biology 8 (4): R56 (2007)
Friedel S; Saar K; Sauer S; Dempfle A; Walitza S; Renner T; Romanos M; Freitag C; Seitz C; Palmason H; Scherag A; Windemuth-Kieselbach C; Schimmelmann BG; Wewetzer C; Meyer J; Warnke A; Lesch KP; Reinhardt R; Herpertz-Dahlmann B; Linder M; Hinney A; Remschmidt H; Schafer H; Konrad K; Huebner N; Hebebrand J
Association and linkage of allelic variants of the dopamine transporter gene in ADHD
Molecular Psychiatry 12 (10): 923-933 (2007-10)
Doss MX; Chen S; Winkler J; Hippler-Altenburg R; Odenthal M; Wickenhauser C; Balaraman S; Schulz H; Hummel O; Huebner N; Ghosh-Choudhury N; Sotiriadou I; Hescheler J; Sachinidis A
Transcriptomic and phenotypic analysis of murine embryonic stem cell derived BMP2+ lineage cells : an insight into mesodermal patterning
Genome Biology 8 (9): R184 (2007)
Lorenz S; Heils A; Kasper JM; Sander T
Allelic association of a truncation mutation of the KCNMB3 gene with idiopathic generalized epilepsy
American Journal of Medical Genetics B 144B (1): 10-13 (2007-01-05)
Hempelmann A; Cobilanschi J; Heils A; Muhle H; Stephani U; Weber Y; Lerche H; Sander T
Lack of evidence of an allelic association of a functional GABRB3 exon 1a promoter polymorphism with idiopathic generalized epilepsy
Epilepsy Research 74 (1): 28-32 (2007-04)
Lee-Kirsch MA; Gong M; Chowdhury D; Senenko L; Engel K; Lee YA; de Silva U; Bailey SL; Witte T; Vyse TJ; Kere J; Pfeiffer C; Harvey S; Wong A; Koskenmies S; Hummel O; Rohde K; Schmidt RE; Dominiczak AF; Gahr M; Hollis T; Perrino FW; Lieberman J; Huebner N
Mutations in the gene encoding the 3-5 DNA exonuclease TREX1 are associated with systemic lupus erythematosus
Nature Genetics 39 (9): 1065-1067 (2007-09)
Heiser P; Dempfle A; Friedel S; Konrad K; Hinney A; Kiefl H; Walitza S; Bettecken T; Saar K; Linder M; Warnke A; Herpertz-Dahlmann B; Schaefer H; Remschmidt H; Hebebrand J
Family-based association study of serotonergic candidate genes and attention-deficit/hyperactivity disorder in a German sample
Journal of Neural Transmission 114 (4): 513-21 (2007)
Dietter J; Mattheisen M; Fuerst R; Rueschendorf F; Wienker TF; Strauch K
Linkage analysis using sex-specific recombination fractions with GENEHUNTER-MODSCORE
Bioinformatics 23: 64-70 (2007-01-01)
Najmabadi H; Motazacker MM; Garshasbi M; Kahrizi K; Tzschach A; Chen W; Behjati F; Hadavi V; Nieh SE; Abedini SS; Vazifehmand R; Firouzabadi SG; Jamali P; Falah M; Seifati SM; Grueters A; Lenzner S; Jensen LR; Rueschendorf F; Kuss AW; Ropers HH
Homozygosity mapping in consanguineous families reveals extreme heterogeneity of non-syndromic autosomal recessive mental retardation and identifies 8 novel gene loci
Human Genetics 121: 43-48 (2007-03-01)
Soederhaell C; Marenholz I; Kerscher T; Rueschendorf F; Esparza-Gordillo J; Worm M; Gruber C; Mayr G; Albrecht M; Rohde K; Schulz H; Wahn U; Huebner N; Lee YA
Variants in a novel epidermal collagen gene (COL29A1) are associated with atopic dermatitis
PLoS Biology 5 (9): 1952-1961 (2007-09)
Schulz F; Marenholz I; Foelster-Holst R; Chen C; Sternjak A; Baumgrass R; Esparza-Gordillo J; Grueber C; Nickel R; Schreiber S; Stoll M; Kurek M; Rueschendorf F; Huebner N; Wahn U; Lee YA
A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczema
Journal of Allergy and Clinical Immunology 120 (5): 1097-1102 (2007-11)
2006
Gedicke MM; Traupe H; Fischer B; Tinschert S; Hennies HC
Towards characterization of palmoplantar keratoderma caused by gain-of-function mutation in loricrin: analysis of a family and review of the literature
British Journal of Dermatology 154: 167-171 (2006-01-01)
Zimdahl H; Huebner N
Gene chip technology and its application to molecular medicine
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 1 : 650-655 (2006-07-05)
Petretto E; Mangion J; Pravanec M; Huebner N; Aitman TJ
Integrated gene expression profiling and linkage analysis in the rat
Mammalian Genome 17: 480-489 (2006-06-12)
Lorenz S; Heils A; Taylor KP; Gehrmann A; Muhle H; Gresch M; Becker T; Tauer U; Stephani U; Sander T
Candidate gene analysis of the succinic semialdehyde dehydrogenase gene (ALDH5A1) in patients with idiopathic generalized epilepsy and photosensitivity
Neuroscience Letters 397 (3): 234-239 (2006-04-24)
Schirmer M; Toliat MR; Haberl M; Suk A; Kamdem LK; Klein K; Brockmoeller J; Nuernberg P; Zanger UM; Wojnowski L
Genetic signature consistent with selection against the CYP3A4*1B allele in non-African populations
Pharmacogenetics and Genomics 16: 59-71 (2006-01-01)
Petretto E; Mangion J; Cook SA; Aitman TJ; Pravenec M; Schulz H; Fischer J; Huebner N
Reply to "Normalization procedures and detection of linkage signal in genetical-genomics experiments"
Nature Genetics 38: 858-859 (2006-08-01)
Blueher M; Engeli S; Kloeting N; Berndt J; Fasshauer M; Batkai S; Pacher P; Schoen MR; Jordan J; Stumvoll M
Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity
Diabetes 55: 3053-3060 (2006-11-01)
Hempelmann A; Kumar S; Muralitharan S; Sander T
Myofibrillogenesis regulator 1 gene (MR-1) mutation in an Omani family with paroxysmal nonkinesigenic dyskinesia
Neuroscience Letters 402 (1-2): 118-120 (2006-07-10)
Mathas S; Janz M; Hummel F; Hummel M; Wollert-Wulf B; Lusatis S; Anagnostopoulos I; Lietz A; Sigvardsson M; Jundt F; Joehrens K; Bommert K; Stein H; Doerken B
Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma
Nature Immunology 7 (2): 207-215 (2006-02)
Todt I; Hennies HC; Kuester W; Smolle J; Rademacher G; Mutze S; Basta D; Eisenschenk A; Ernst A
Neurotological and neuroanatomical changes in the connexin-26-related HID/KID syndrome
Audiology & Neurootology 11: 242-248 (2006-05-04)
Chioza B; Everett K; Aschauer H; Brouwer O; Callenbach P; Covanis A; Dulac O; Durner M; Eeg-Olofsson O; Feucht M; Friis M; Heils A; Kjeldsen M; Larsson K; Lehesjoki AE; Nabbout R; Olsson I; Sander T; Siren A; Robinson R; Rees M; Gardiner RM
Evaluation of CACNA1H in European patients with childhood absence epilepsy
Epilepsy Research 69: 177-181 (2006-05-01)
von Brevern M; Ta N; Shankar A; Wiste A; Siegel A; Radtke A; Sander T; Escayg A
Migrainous vertigo: mutation analysis of the candidate genes CACNA1A, ATP1A2, SCN1A, and CACNB4
Headache 46: 1136-1141 (2006-07-01)
Vanita V; Singh JR; Hejtmancik JF; Nuernberg P; Hennies HC; Singh D; Sperling K
A novel fan-shaped cataract-microcornea syndrome caused by a mutation of CRYAA in an Indian family
Molecular Vision 12: 518-522 (2006-05-22)
Kirchheiner J; Lang U; Stamm T; Sander T; Gallinat J
Association of CYP2D6 genotypes and personality traits in healthy individuals
Journal of Clinical Psychopharmacology 26: 440-442 (2006-08-01)
Garshasbi M; Motazacker MM; Kahrizi K; Behjati F; Abedini SS; Nieh SE; Firouzabadi SG; Becker C; Rueschendorf F; Nuernberg P; Tzschach A; Vazifehmand R; Erdogan F; Ullmann R; Lenzner S; Kuss AW; Ropers HH; Najmabadi H
SNP array-based homozygosity mapping reveals MCPH1 deletion in family with autosomal recessive mental retardation and mild microcephaly
Human Genetics 118: 708-715 (2006-02-01)
Vanita V; Hejtmancik JF; Hennies HC; Guleria K; Nuernberg P; Singh D; Sperling K; Singh JR
Sutural cataract associated with a mutation in the ferritin light chain gene (FTL) in a family of Indian origin
Molecular Vision 12: 93-99 (2006-01-01)
Hempelmann A; Heils A; Sander T
Confirmatory evidence for an association of the connexin-36 gene with juvenile myoclonic epilepsy
Epilepsy Research 71 (2-3): 223-228 (2006-10)
Wolf MT; Mucha BE; Hennies HC; Attanasio M; Panther F; Zalewski I; Karle SM; Otto EA; Deltas CC; Fuchshuber A; Hildebrandt F
Medullary cystic kidney disease type 1: mutational analysis in 37 genes based on haplotype sharing
Human Genetics 119: 649-658 (2006-04-26)
Rubattu S; Huebner N; Ganten U; Evangelista A; Stanzione R; Angelantonio ED; Plehm R; Langanki R; Gianazza E; Sironi L; D'Amati G; Volpe M
Reciprocal congenic lines for a major stroke-QTL on rat chromosome 1
Physiological Genomics 27: 108-113 (2006-10-11)
Guryev V; Smits BM; van de Belt J; Verheul M; Huebner N; Cuppen E
Haplotype block structure is conserved across mammals
PLoS Genetics 2 (7): 1111-1118 (2006-07)
Lorenz S; Taylor KP; Gehrmann A; Becker T; Muhle H; Gresch M; Tauer U; Sander T; Stephani U
Association of BRD2 polymorphisms with photoparoxysmal response
Neuroscience Letters 400 (1-2): 135-139 (2006-05-29)
Huebner N; Yagil C; Yagil Y
Novel integrative approaches to the identification of candidate genes in hypertension
Hypertension 47 (1): 1-5 (2006-01)
Maerschenz S; Endres AS; Brinckmann A; Heise T; Kristiansen G; Nuernberg P; Krueger DH; Guenther S; Meisel H
Functional analysis of complex hepatitis B virus variants associated with development of liver cirrhosis
Gastroenterology 131: 765-780 (2006-09-01)
Fehr C; Sander T; Tadic A; Lenzen KP; Anghelescu I; Klawe C; Dahmen N; Schmidt LG; Szegedi A
Confirmation of association of the GABRA2 gene with alcohol dependence by subtype-specific analysis
Psychiatric Genetics 16: 9-17 (2006-02-01)
Blaydon DC; Ishii Y; O'Toole EA; Unsworth HC; Teh MT; Rueschendorf F; Sinclair C; Hopsu-Havu VK; Tidman N; Moss C; Watson R; de Berker D; Wajid M; Christiano AM; Kelsell DP
The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia
Nature Genetics 38: 1245-1247 (2006-10-15)
Ciana G; Trappan A; Bembi B; Benettoni A; Maso G; Zennaro F; Ruf N; Schnabel D; Rutsch F
Generalized arterial calcification of infancy: two siblings with prolonged survival
European Journal of Pediatrics 165: 258-263 (2006-04-01)
Rauch A; Hoyer J; Guth S; Zweier C; Kraus C; Becker C; Zenker M; Hueffmeier U; Thiel C; Rueschendorf F; Nuernberg P; Reis A; Trautmann U
Diagnostic yield of various genetic approaches in patients with unexplained developmental delay or mental retardation
American Journal of Medical Genetics A 140A: 2063-2074 (2006-08-17)
Lee-Kirsch MA; Gong M; Schulz H; Rueschendorf F; Stein A; Pfeiffer C; Ballarini A; Gahr M; Huebner N; Linne M
Familial chilblain lupus, a monogenic form of cutaneous lupus erythematosus, maps to chromosome 3p
American Journal of Human Genetics 79: 731-737 (2006-10-01)
Dempfle A; Wudy SA; Saar K; Hagemann S; Friedel S; Scherag A; Berthold LD; Alzen G; Gortner L; Blum WF; Hinney A; Nuernberg P; Schaefer H; Hebebrand J
Evidence for involvement of the vitamin D receptor gene in idiopathic short stature via a genome-wide linkage study and subsequent association studies
Human Molecular Genetics 15 (18): 2772-2783 (2006-09-15)
Petretto E; Mangion J; Dickens NJ; Cook SA; Kumaran MK; Lu H; Fischer J; Maatz H; Kren V; Pravenec M; Huebner N; Aitman TJ
Heritability and tissue specificity of expression quantitative trait loci
PLoS Genetics 2 (10): 1625-1633 (2006-10-20)
Entz P; Blaumeiser B; Betz RC; Lambert J; Seymons K; Eigelshoven S; Hanneken S; Kruse R; Nuernberg P; Nagy M; Noethen MM
Investigation of the HLA-DRB1 locus in alopecia areata
European Journal of Dermatology 16: 363-367 (2006-07-01)
Lohoff FW; Dahl JP; Ferraro TN; Arnold SE; Gallinat J; Sander T; Berrettini WH
Variations in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) are associated with bipolar I disorder
Neuropsychopharmacology 31 (12): 2739-2747 (2006-12)
Stadt UZ; Beutel K; Kolberg S; Schneppenheim R; Kabisch H; Janka G; Hennies HC
Mutation spectrum in children with primary hemophagocytic lymphohistiocytosis: molecular and functional analyses of PRF1, UNC13D, STX11, and RAB27A
Human Mutation 27: 62-68 (2006-01-01)
Hebebrand J; Dempfle A; Saar K; Thiele H; Herpertz-Dahlmann B; Linder M; Kiefl H; Remschmidt H; Hemminger U; Warnke A; Knoelker U; Heiser P; Friedel S; Hinney A; Schaefer H; Nuernberg P; Konrad K
A genome-wide scan for attention-deficit/hyperactivity disorder in 155 german sib-pairs
Molecular Psychiatry 11: 196-205 (2006-02-01)
Gong M; Huebner N
Molecular genetics of human hypertension
Clinical Science 110 (3): 315-326 (2006-03)
Hempelmann A; Taylor KP; Heils A; Lorenz S; Prud'Homme JF; Nabbout R; Dulac O; Rudolf G; Zara F; Bianchi A; Robinson R; Gardiner RM; Covanis A; Lindhout D; Stephani U; Elger CE; Weber YG; Lerche H; Nuernberg P; Kron KL; Scheffer IE; Mulley JC; Berkovic SF; Sander T
Exploration of the genetic architecture of idiopathic generalized epilepsies
Epilepsia 47 (10): 1682-1690 (2006-10)
Steffens M; Lamina C; Illig T; Bettecken T; Vogler R; Entz P; Suk EK; Toliat MR; Klopp N; Caliebe A; Koenig IR; Koehler K; Luedemann J; Lacava AD; Fimmers R; Lichtner P; Ziegler A; Wolf A; Krawczak M; Nuernberg P; Hampe J; Schreiber S; Meitinger T; Wichmann HE; Roeder K; Wienker TF; Baur MP
SNP-Based analysis of genetic substructure in the German population
Human Heredity 62: 20-29 (2006-09-21)
Huebner N
Expressing physiology
Nature Genetics 38 (2): 140-141 (2006-02)
Marenholz I; Nickel R; Rueschendorf F; Schulz F; Esparza-Gordillo J; Kerscher T; Grueber C; Lau S; Worm M; Keil T; Kurek M; Zaluga E; Wahn U; Lee YA
Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march
Journal of Allergy and Clinical Immunology 118 (4): 866-871 (2006-10)
Zheng W; Rosenstiel P; Huse K; Sina C; Valentonyte R; Mah N; Zeitlmann L; Grosse J; Ruf N; Nuernberg P; Costello CM; Onnie C; Mathew C; Platzer M; Schreiber S; Hampe J
Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease
Genes and Immunity 7: 11-18 (2006-01-01)
2005
Metherell LA; Chapple JP; Cooray S; David A; Becker C; Rueschendorf F; Naville D; Begeot M; Khoo B; Nuernberg P; Huebner A; Cheetham ME; Clark AJL
Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2
Nature Genetics 37: 166-170 (2005-01-01)
Lang UE; Hellweg R; Kalus P; Bajbouj M; Lenzen KP; Sander T; Kunz D; Gallinat J
Association of a functional BDNF polymorphism and anxiety-related personality traits
Psychopharmacology 180: 95-99 (2005-01-01)
Lenzen KP; Heils A; Lorenz S; Hempelmann A; Hoefels S; Lohoff FW; Schmitz B; Sander T
Supportive evidence for an allelic association of the human KCNJ10 potassium channel gene with idiopathic generalized epilepsy
Epilepsy Research 63: 113-118 (2005-01-01)
Yagil C; Huebner N; Monti J; Schulz H; Sapojnikov M; Luft FC; Ganten D; Yagil Y
Identification of hypertension-related genes through an integrated genomic-transcriptomic approach
Circulation Research 96: 617-625 (2005-01-01)
Kurz T; Altmueller J; Strauch K; Rueschendorf F; Heinzmann A; Moffatt MF; Cookson WOCM; Inacio F; Nuernberg P; Stassen HH; Deichmann KA
A genome-wide screen on the genetics of atopy in a multiethnic European population reveals a major atopy locus on chromosome 3q21.3
Allergy 60: 192-199 (2005-01-01)
Tauer U; Lorenz S; Lenzen KP; Heils A; Muhle H; Gresch M; Neubauer BA; Waltz S; Rudolf G; Mattheisen M; Strauch K; Schmitz B; Stephani U; Sander T
Genetic dissection of photosensitivity and its relation to idiopathic generalized epilepsy
Annals of Neurology 57: 866-873 (2005-01-01)
Schmitt B; Wohlrab G; Sander T; Steinlein OK; Hajnal BL
Neonatal seizures with tonic clonic sequences and poor developmental outcome
Epilepsy Research 65: 161-168 (2005-07-01)
Reinhard C; Meyer B; Fuchs H; Stoeger T; Eder G; Rueschendorf F; Heyder J; Nuernberg P; Hrabe de Angelis M; Schulz H
Genomewide linkage analysis identifies novel genetic loci for lung function in mice
American Journal of Respiratory and Critical Care Medicine 171: 880-888 (2005-01-07)
Rueschendorf F; Nuernberg P
ALOHOMORA: a tool for linkage analysis using 10K SNP array data
Bioinformatics 21: 2123-2125 (2005-01-01)
Strauch K; Fuerst R; Rueschendorf F; Windemuth C; Dietter J; Flaquer A; Baur MP; Wienker TF
Linkage analysis of alcohol dependence using MOD scores
BMC Genetics 6 (Suppl 1): S162 (2005-12-30)
Huebner N; Wallace CA; Zimdahl H; Petretto E; Schulz H; Maciver F; Mueller M; Hummel O; Monti J; Zidek V; Musilova A; Kren V; Causton H; Game L; Born G; Schmidt S; Mueller A; Cook SA; Kurtz TW; Whittaker J; Pravenec M; Aitman TJ
Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease
Nature Genetics 37 (3): 243-253 (2005-03-01)
Lenzen KP; Heils A; Lorenz S; Hempelmann A; Sander T
Association analysis of the Arg220His variation of the human gene encoding the GABA delta subunit with idiopathic generalized epilepsy
Epilepsy Research 65 (1-2): 53-57 (2005-06)
Thiel CT; Horn D; Zabel B; Ekici AB; Salinas K; Gebhart E; Rueschendorf F; Sticht H; Spranger J; Mueller D; Zweier C; Schmitt ME; Reis A; Rauch A
Severely incapacitating mutations in patients with extreme short stature identify RNA-processing endoribonuclease RMRP as an essential cell growth regulator
American Journal of Human Genetics 77 (5): 795-806 (2005-11-01)
Gu W; Sander T; Heils A; Lenzen KP; Steinlein OK
A new EF-hand containing gene EFHC2 on Xp11.4: Tentative evidence for association with juvenile myoclonic epilepsy
Epilepsy Research 66: 91-98 (2005-08-18)
Lohoff FW; Sander T; Ferraro TN; Dahl JP; Gallinat J; Berrettini WH
Confirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder
American Journal of Medical Genetics B 139: 51-53 (2005-11-05)
Hammes A; Andreassen TK; Spoelgen R; Raila J; Huebner N; Schulz H; Metzger J; Schweigert FJ; Luppa PB; Nykjaer A; Willnow TE
Role of endocytosis in cellular uptake of sex steroids
Cell 122: 751-762 (2005-09-09)
Altmueller J; Seidel C; Lee YA; Loesgen S; Bulle D; Friedrichs F; Jellouschek H; Kelber J; Keller A; Schuster A; Silbermann M; Wahlen W; Wolff P; Rueschendorf F; Schlenvoigt G; Nuernberg P; Wjst M
Phenotypic and genetic heterogeneity in a genome-wide linkage study of asthma families
BMC Pulmonary Medicine 5: 1 (2005-01-05)
Wenzel K; Zabojszcza J; Carl M; Taubert S; Lass A; Harris CL; Ho M; Schulz H; Hummel O; Huebner N; Osterziel KJ; Spuler S
Increased susceptibility to complement attack due to down-regulation of decay-accelerating factor/CD55 in dysferlin-deficient muscular dystrophy
Journal of Immunology 175: 6219-6225 (2005-11-01)
Lenzen KP; Heils A; Lorenz S; Hempelmann A; Sander T
Association analysis of malic enzyme 2 gene polymorphisms with idiopathic generalized epilepsy
Epilepsia 46: 1637-1641 (2005-10-01)
2004
Metherell LA; Cooray S; Huebner A; Rueschendorf F; Naville D; Begeot M; Clark AJL
Mutations in a novel gene, encoding a single transmembrane domain protein are associated with familial glucocorticoid deficiency type 2
Endocrine Research 30: 889-890 (2004-01-01)
Bayer Y; Neumann S; Meyer B; Rueschendorf F; Reske A; Brix T; Hegedues L; Langer P; Nuernberg P; Paschke R
Genome-wide linkage analysis reveals evidence for four new susceptibility loci for familial euthyroid goiter
Journal of Clinical Endocrinology and Metabolism 89: 4044-4052 (2004-01-01)
Kaindl AM; Rueschendorf F; Krause S; Goebel HH; Koehler K; Becker C; Pongratz D; Mueller-Hoecker J; Nuernberg P; Stoltenburg-Didinger G; Lochmueller H; Huebner A
Missense mutations of ACTA1 cause dominant congenital myopathy with cores
Journal of Medical Genetics 41: 842-848 (2004-01-01)
Rauch A; Rueschendorf F; Huang J; Trautmann U; Becker C; Thiel C; Jones KW; Reis A; Nuernberg P
Molecular karyotyping using an SNP array for genomewide genotyping
Journal of Medical Genetics 41: 916-922 (2004-01-01)
Janecke AR; Thompson DA; Utermann G; Becker C; Huebner CA; Schmid E; McHenry CL; Nair AR; Rueschendorf F; Heckenlively J; Wissinger B; Nuernberg P; Gal A
Mutations in RDH12 encoding a photoreceptor cell retinol dehydrogenase cause childhood-onset severe retinal dystrophy
Nature Genetics 36: 850-854 (2004-01-01)
Zimdahl H; Nyakatura G; Brandt P; Schulz H; Hummel O; Fartmann B; Brett D; Droege M; Monti J; Lee YA; Sun YY; Zhao SY; Winter EE; Ponting CP; Chen Y; Kasprzyk A; Birney E; Ganten D; Huebner N
A SNP map of the rat genome generated from cDNA sequences
Science 303: 807-807 (2004-01-01)
Zechner U; Shi W; Hemberger M; Himmelbauer H; Otto S; Orth A; Kalscheuer V; Fischer U; Elango R; Reis A; Vogel W; Ropers H; Rueschendorf F; Fundele R
Divergent genetic and epigenetic post-zygotic isolation mechanisms in Mus and Peromyscus
Journal of Evolutionary Biology 17: 453-460 (2004-01-01)
Krzywinski M; Wallis J; Goesele C; Bosdet I; Chiu R; Graves T; Hummel O; Layman D; Mathewson C; Wye N; Zhu B; Albracht D; Asano J; Barber S; Brown-John M; Chan S; Chand S; Cloutier A; Davito J; Fjell C; Gaige T; Ganten D; Girn N; Guggenheimer K; Himmelbauer H; Kreitler T; Leach S; Lee D; Lehrach H; Mayo M; Mead K; Olson T; Pandoh P; Prabhu AL; Shin H; Taenzer S; Thompson J; Tsai M; Walker J; Yang G; Sekhon M; Hillier L; Zimdahl H; Marziali A; Osoegawa K; Zhao S; Siddiqui A; de Jong PJ; Warren W; Mardis E; McPherson JD; Wilson R; Huebner N; Jones S; Marra M; Schein J
Integrated and sequence-ordered BAC- and YAC-based physical maps for the rat genome
Genome Research 14: 766-779 (2004-01-01)
Uhlenberg B; Schuelke M; Rueschendorf F; Ruf N; Kaindl AM; Henneke M; Thiele H; Stoltenburg-Didinger G; Aksu F; Topaloglu H; Nuernberg P; Huebner C; Weschke B; Gaertner J
Mutations in the gene encoding gap junction protein alpha 12 (connexin 46.6) cause Pelizaeus-Merzbacher-like disease
American Journal of Human Genetics 75 (2): 251-260 (2004-08)
Liska F; Goesele C; Kren V; Huebner N; Krenova D
Molecular analysis of the sex hormone-binding globulin gene in the rat hypodactylous mutation (Hd)
Folia Biologica Prague 50: 63-68 (2004-01-01)
2003
Gong M; Zhang HY; Schulz H; Lee YA; Sun K; Baehring S; Luft FC; Nuernberg P; Reis A; Rohde K; Ganten D; Hui RT; Huebner N
Genome-wide linkage reveals a locus for human essential (primary) hypertension on chromosome 12p
Human Molecular Genetics 12: 1273-1277 (2003-01-01)
Yagil C; Huebner N; Kreutz R; Ganten D; Yagil Y
Congenic strains confirm the presence of salt-sensitivity QTLs on chromosome 1 in the Sabra rat model of hypertension
Physiological Genomics 12: 85-95 (2003-01-01)
Monti J; Zimdahl H; Schulz H; Plehm R; Ganten D; Huebner N
The role of Wnk4 in polygenic hypertension - A candidate gene analysis on rat chromosome 10
Hypertension 41: 938-942 (2003-01-01)
Monti J; Plehm R; Schulz H; Ganten D; Kreutz R; Huebner N
Interaction between blood pressure quantitative trait loci in rats in which trait variation at chromosome 1 is conditional upon a specific allele at chromosome 10
Human Molecular Genetics 12: 435-439 (2003-01-01)
Gotthardt M; Hammer RE; Huebner N; Monti J; Witt CC; McNabb M; Richardson JA; Granzier H; Labeit S; Herz J
Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure
Journal of Biological Chemistry 278: 6059-6065 (2003-01-01)
2002
Barta P; Monti J; Maass PG; Gorzelniak K; Mueller DN; Dechend R; Luft FC; Huebner N; Sharma AM
A gene expression analysis in rat kidney following high and low salt intake
Journal of Hypertension 20: 1115-1120 (2002-01-01)
Oezcelik C; Erdmann B; Pilz B; Wettschureck N; Britsch S; Huebner N; Chien KR; Birchmeier C; Garratt AN
Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy
Proceedings of the National Academy of Sciences of the United States of America 99: 8880-8885 (2002-01-01)
Zimdahl H; Kreitler T; Goesele C; Ganten D; Huebner N
Conserved synteny in rat and mouse for a blood pressure QTL on human chromosome 17
Hypertension 39: 1050-1052 (2002-01-01)
Kreutz R; Huebner N
Congenic rat strains are important tools for the genetic dissection of essential hypertension
Seminars in Nephrology 22: 135-147 (2002-01-01)
1997
Lee MA; Cai L; Huebner N; Lee YA; Lindpaintner K
Tissue and development specific expression of multiple alternatively spliced transcripts of rat neuronal nitric oxide synthase
Journal of Clinical Investigation 100 (6): 1507-1512 (1997-09-15)