Publications
2012
Terwey TH; Vega-Ruiz A; Hemmati PG; Martus P; Dietz E; le Coutre P; Massenkeil G; Doerken B; Arnold R
NIH-defined graft-versus-host disease after reduced intensity or myeloablative conditioning in patients with acute myeloid leukemia
Leukemia 26 (3): 536-542 (2012-03)
Engert A; Haverkamp H; Kobe C; Markova J; Renner C; Ho A; Zijlstra J; Kral Z; Fuchs M; Hallek M; Kanz L; Doehner H; Doerken B; Engel N; Topp M; Klutmann S; Amthauer H; Bockisch A; Kluge R; Kratochwil C; Schober O; Greil R; Andreesen R; Kneba M; Pfreundschuh M; Stein H; Eich HT; Mueller RP; Dietlein M; Borchmann P; Diehl V
Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin's lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trial
Lancet 379 (9828): 1791-1799 (2012-05-12)
Volcic M; Karl S; Baumann B; Salles D; Daniel P; Fulda S; Wiesmueller L
NF-{kappa}B regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes
Nucleic Acids Research 40 (1): 181-195 (2012-01-01)
Nguyen-Hoai T; Baldenhofer G; Sayed Ahmed MS; Pham-Duc M; Vu MD; Lipp M; Doerken B; Pezzutto A; Westermann J
CCL21 (SLC) improves tumor protection by a DNA vaccine in a Her2/neu mouse tumor model
Cancer Gene Therapy 19 (1): 69-76 (2012)
Muer A; Overkamp T; Gillissen B; Richter A; Pretzsch T; Milojkovic A; Doerken B; Daniel PT; Hemmati P
p14ARF-induced apoptosis in p53-deficient cells is mediated by the BH3-only protein independent de-repression of Bak through down-regulation of Mcl-1 and Bcl-xL
Journal of Biological Chemistry : (2012-02-21)
Frick M; Doerken B; Lenz G
New insights into the biology of molecular subtypes of diffuse large B-cell lymphoma and Burkitt lymphoma
Best Practice and Research Clinical Haematology 25 (1): 3-12 (2012-03)
Schwarzer R; Doerken B; Jundt F
Notch is an essential upstream regulator of NF-{kappa}B and is relevant for survival of Hodgkin and Reed-Sternberg cells
Leukemia 26 (4): 806-813 (2012-04)
Ploetz M; Hossini AM; Gillissen B; Daniel PT; Stockfleth E; Eberle J
Mutual regulation of Bcl-2 proteins independent of the BH3 domain as shown by the BH3-lacking protein Bcl-x(AK)
PLoS ONE 7 (4): e34549 (2012-04-10)
Schmetzer O; Moldenhauer G; Nicolaou A; Schlag P; Riesenberg R; Pezzutto A
Detection of circulating tumor-associated antigen depends on the domains recognized by the monoclonal antibodies used: N-terminal trimmed EpCAM-levels are much higher than untrimmed forms
Immunology Letters 143 (2): 184-192 (2012-04-30)
Nguyen-Hoai T; Baldenhofer G; Ahmed MS; Pham-Duc M; Gries M; Lipp M; Doerken B; Pezzutto A; Westermann J
CCL19 (ELC) improves TH1-polarized immune responses and protective immunity in a murine Her2/neu DNA vaccination model
Journal of Gene Medicine 14 (2): 128-137 (2012-02)
Kim TD; le Coutre P; Schwarz M; Grille P; Levitin M; Fateh-Moghadam S; Giles FJ; Doerken B; Haverkamp W; Koehncke C
Clinical cardiac safety profile of nilotinib
Haematologica : (2012-01-22)
Lamprecht B; Kreher S; Moebs M; Sterry W; Doerken B; Janz M; Assaf C; Mathas S
The tumor suppressor p53 is frequently non-functional in Sézary syndrome
British Journal of Dermatology : (2012-03-02)
Hoepken UE; Rehm A
Homeostatic chemokines guide lymphoma cells to tumor growth-promoting niches within secondary lymphoid organs
Journal of Molecular Medicine : (2012-05-11)
2011
Hemmati PG; Terwey TH; le Coutre P; Vuong LG; Massenkeil G; Doerken B; Arnold R
A modified EBMT risk score predicts the outcome of patients with acute myeloid leukemia receiving allogeneic stem cell transplants
European Journal of Haematology 86 (4): 305-316 (2011-04)
Kloo B; Nagel D; Pfeifer M; Grau M; Duewel M; Vincendeau M; Doerken B; Lenz P; Lenz G; Krappmann D
Critical role of PI3K signaling for NF-{kappa}B-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells
Proceedings of the National Academy of Sciences of the United States of America 108 (1): 272-277 (2011-01-04)
Anders K; Buschow C; Herrmann A; Milojkovic A; Loddenkemper C; Kammertoens T; Daniel P; Yu H; Charo J; Blankenstein T
Oncogene-targeting T cells reject large tumors while oncogene inactivation selects escape variants in mouse models of cancer
Cancer Cell 20 (6): 755-767 (2011-12-13)
Hailfinger S; Nogai H; Pelzer C; Jaworski M; Cabalzar K; Charton JE; Guzzardi M; Decaillet C; Grau M; Doerken B; Lenz P; Lenz G; Thome M
Malt1-dependent RelB cleavage promotes canonical NF-{kappa}B activation in lymphocytes and lymphoma cell lines
Proceedings of the National Academy of Sciences of the United States of America 108 (35): 14596-14601 (2011-08-30)
Fagerli UM; Ullrich K; Stuehmer T; Holien T; Koechert K; Holt RU; Bruland O; Chatterjee M; Nogai H; Lenz G; Shaughnessy JD; Mathas S; Sundan A; Bargou RC; Doerken B; Borset M; Janz M
Serum/glucocorticoid-regulated kinase 1 (SGK1) is a prominent target gene of the transcriptional response to cytokines in multiple myeloma and supports the growth of myeloma cells
Oncogene 30 (28): 3198-3206 (2011-07-14)
Winter S; Rehm A; Wichner K; Scheel T; Batra A; Siegmund B; Berek C; Lipp M; Hoepken UE
Manifestation of spontaneous and early autoimmune gastritis in CCR7-deficient mice
American Journal of Pathology 179 (2): 754-765 (2011-08)
Pelzer U; Arnold D; Reitzig P; Herrenberger J; Korsten FW; Kindler M; Stieler J; Doerken B; Riess H; Oettle H
First-line treatment of pancreatic cancer patients with the combination of 5-fluorouracil/folinic acid plus gemcitabine: a multicenter phase II trial by the CONKO-study group
Cancer Chemotherapy and Pharmacology 68 (5): 1173-1178 (2011-11)
von Haefen C; Wendt J; Semini G; Sifringer M; Belka C; Radetzki S; Reutter W; Daniel PT; Danker K
Synthetic glycosidated phospholipids induce apoptosis through activation of FADD, caspase-8 and the mitochondrial death pathway
Apoptosis 16 (6): 636-651 (2011-03-25)
Naylor TL; Tang H; Ratsch BA; Enns A; Loo A; Chen L; Lenz P; Schuler W; Doerken B; Yao YM; Warmuth M; Lenz G; Stegmeier F
Protein kinase C inhibitor Sotrastaurin selectively inhibits the growth of CD79-mutant diffuse large B-cell lymphomas
Cancer Research 71 (7): 2643-2653 (2011-04-01)
Kim TD; Schwarz M; Kreuzer KA; Kaeda J; Movassaghi K; Grille P; Daniel PT; Doerken B; le Coutre P
Long-term follow-up of patients with Philadelphia chromosome-positive chronic myeloid leukemia after stem cell mobilization under imatinib
Leukemia & Lymphoma 52 (3): 517-520 (2011-03)
Mielke N; Schwarzer R; Calkhoven CF; Kaufman R; Doerken B; Leutz A; Jundt F
Eukaryotic initiation factor 2{alpha} phosphorylation is required for B cell maturation and function in mice
Haematologica 96 (9): 1261-1268 (2011-09)
Westermann J; Floercken A; Willimsky G; van Lessen A; Kopp J; Takvorian A; Joehrens K; Lukowsky A; Schoenemann C; Sawitzki B; Pohla H; Frank R; Doerken B; Schendel DJ; Blankenstein T; Pezzutto A
Allogeneic gene-modified tumor cells (RCC-26/IL-7/CD80) as a vaccine in patients with metastatic renal cell cancer: a clinical phase-I study
Gene Therapy 18 (4): 354-363 (2011-04)
Rahnefeld A; Ebstein F; Albrecht N; Opitz E; Kuckelkorn U; Stangl K; Rehm A; Kloetzel PM; Voigt A
Antigen-presentation capacity of dendritic cells is impaired in ongoing enterovirus myocarditis
European Journal of Immunology 41 (9): 2774-2781 (2011-09)
Koechert K; Ullrich K; Kreher S; Aster JC; Kitagawa M; Joehrens K; Anagnostopoulos I; Jundt F; Lamprecht B; Zimber-Strobl U; Stein H; Janz M; Doerken B; Mathas S
High-level expression of Mastermind-like 2 contributes to aberrant activation of the NOTCH signaling pathway in human lymphomas
Oncogene 30 (15): 1831-1840 (2011-04-14)
Pelzer U; Schwaner I; Stieler J; Adler M; Seraphin J; Doerken B; Riess H; Oettle H
Best supportive care (BSC) versus oxaliplatin, folinic acid and 5-fluorouracil (OFF) plus BSC in patients for second-line advanced pancreatic cancer: A phase III-study from the German CONKO-study group
European Journal of Cancer 47 (11): 1676-1681 (2011-07)
Floercken A; Takvorian A; Van Lessen A; Singh A; Hopfenmueller W; Doerken B; Pezzutto A; Westermann J
Sorafenib, but not sunitinib, induces regulatory T cells in the peripheral blood of patients with metastatic renal cell carcinoma
Anti-Cancer Drugs : (2011-12-12)
Ratsch BA; Grau M; Doerken B; Lenz P; Lenz G
The use of microarray technologies in mantle cell lymphoma
Seminars in Hematology 48 (3): 166-171 (2011-07)
Schwarzer R; Jundt F
Notch and NF-kappaB signaling pathways in the biology of classical Hodgkin lymphoma
Current Molecular Medicine 11 (3): 236-245 (2011-04-01)
Ullrich K; Wurster KD; Lamprecht B; Koechert K; Engert A; Doerken B; Janz M; Mathas S
BAY 43-9006/Sorafenib blocks CSF1R activity and induces apoptosis in various classical Hodgkin lymphoma cell lines
British Journal of Haematology 155 (3): 398-402 (2011-11)
Graupner V; Alexander E; Overkamp T; Rothfuss O; De Laurenzi V; Gillissen BF; Daniel PT; Schulze-Osthoff K; Essmann F
Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level
Cell Death and Differentiation 18 (7): 1130-1139 (2011-07)
2010
Ratei R; Hummel M; Anagnostopoulos I; Jaehne D; Arnold R; Doerken B; Mathas S; Thomas B; Dudeck O; Ludwig WD; Stein H
Common clonal origin of an acute B lymphoblastic leukemia and a Langerhans' cell sarcoma: evidence for hematopoietic plasticity
Haematologica 95 (9): 1461-1466 (2010-09)
Yuerek S; Riess H; Kreher S; Doerken B; Salama A
Fatal immune haemolysis due to antibodies to individual metabolites of 5-fluorouracil
Transfusion Medicine 20 (4): 265-268 (2010-08-01)
le Coutre P; Reinke P; Neuhaus R; Trappe R; Ringel F; Lalancette M; Hemmati PG; Doerken B; Daniel PT
BCR-ABL positive cells and chronic myeloid leukemia in immune suppressed organ transplant recipients
European Journal of Haematology 84 (1): 26-33 (2010-01-01)
Kim TD; Tuerkmen S; Schwarz M; Koca G; Nogai H; Bommer C; Doerken B; Daniel P; le Coutre P
Impact of additional chromosomal aberrations and BCR-ABL kinase domain mutations on the response to nilotinib in Philadelphia chromosome-positive chronic myeloid leukemia
Haematologica 95 (4): 582-588 (2010-04)
Kim TD; Schwarz M; Nogai H; Grille P; Westermann J; Ploeckinger U; Braun D; Schweizer U; Arnold R; Doerken B; le Coutre P
Thyroid dysfunction caused by second-generation tyrosine kinase inhibitors in Philadelphia chromosome-positive chronic myeloid leukemia
Thyroid 20 (11): 1209-1214 (2010-11)
Gillissen B; Wendt J; Richter A; Richter A; Mueer A; Overkamp T; Gebhardt N; Preissner R; Belka C; Doerken B; Daniel PT
Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma
Journal of Cell Biology 188 (6): 851-862 (2010-03-22)
Haugstetter AM; Loddenkemper C; Lenze D; Groene J; Standfuss C; Petersen I; Doerken B; Schmitt CA
Cellular senescence predicts treatment outcome in metastasised colorectal cancer
British Journal of Cancer 103 (4): 505-509 (2010-08-10)
Wolf J; Reimer TA; Schuck S; Rueder C; Gerlach K; Mueller EC; Otto A; Doerken B; Rehm A
Role of EBAG9 protein in coat protein complex I-dependent glycoprotein maturation and secretion processes in tumor cells
FASEB Journal 24 (10): 4000-4019 (2010-06-22)
Lamprecht B; Bonifer C; Mathas S
Repeat-element driven activation of proto-oncogenes in human malignancies
Cell Cycle 9 (21): 4276-4281 (2010-11)
Li M; Jung A; Ganswindt U; Marini P; Friedl A; Daniel PT; Lauber K; Jendrossek V; Belka C
Aurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathways
Biochemical Pharmacology 79 (2): 122-129 (2010-01-15)
Reimann M; Lee S; Loddenkemper C; Doerr JR; Tabor V; Aichele P; Stein H; Doerken B; Jenuwein T; Schmitt CA
Tumor stroma-derived TGF-beta limits Myc-driven lymphomagenesis via Suv39h1-dependent senescence
Cancer Cell 17 (3): 262-272 (2010-03-16)
Terwey TH; Hemmati PG; Martus P; Dietz E; Vuong LG; Massenkeil G; Doerken B; Arnold R
A modified EBMT risk score and the hematopoietic cell transplantation-specific comorbidity index for pre-transplant risk assessment in adult acute lymphoblastic leukemia
Haematologica 95 (5): 810-818 (2010-05)
Engert A; Pluetschow A; Eich HT; Lohri A; Doerken B; Borchmann P; Berger B; Greil R; Willborn KC; Wilhelm M; Debus J; Eble MJ; Soekler M; Ho A; Rank A; Ganser A; Truemper L; Bokemeyer C; Kirchner H; Schubert J; Kral Z; Fuchs M; Mueller-Hermelink HK; Mueller RP; Diehl V
Reduced treatment intensity in patients with early-stage Hodgkin's lymphoma
New England Journal of Medicine 363 (7): 640-652 (2010-08-12)
Lamprecht B; Walter K; Kreher S; Kumar R; Hummel M; Lenze D; Koechert K; Bouhlel MA; Richter J; Soler E; Stadhouders R; Joehrens K; Wurster KD; Callen DF; Harte MF; Giefing M; Barlow R; Stein H; Anagnostopoulos I; Janz M; Cockerill PN; Siebert R; Doerken B; Bonifer C; Mathas S
Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma
Nature Medicine 16 (5): 571-579, 1p following 579 (2010-05)
Pelzer U; Arnold D; Govercin M; Stieler J; Doerken B; Riess H; Oettle H
Parenteral nutrition support for patients with pancreatic cancer. Results of a phase II study
BMC Cancer 10 (1): 86 (2010-03-09)
Hemmati PG; Mueer A; Gillissen B; Overkamp T; Milojkovic A; Wendt J; Doerken B; Daniel PT
Systematic genetic dissection of p14(ARF)-mediated mitochondrial cell death signaling reveals a key role for p21(CDKN1) and the BH3-only protein Puma/bbc3
Journal of Molecular Medicine 88 (6): 609-622 (2010-06)
2009
Westermann J; Hecker AC; Floercken A; Doerken B; Pezzutto A
Granulocyte macrophage-colony stimulating factor plus interleukin-2 plus alpha-interferon plus 5-fluorouracil in the treatment of metastatic renal cell cancer: induction of CD80/86+ T cells indicates adverse outcome
Journal of Immunotherapy 32 (6): 667-675 (2009-07)
le Coutre P; Meisel H; Hofmann J; Roecken C; Vuong GL; Neuburger S; Hemmati PG; Doerken B; Arnold R
Reactivation of hepatitis E infection in a patient with acute lymphoblastic leukaemia after allogeneic stem cell transplantation
Gut 58 (5): 699-702 (2009-05)
Fuellbeck M; Dunkel M; Hossbach J; Daniel PT; Preissner R
Cellular fingerprints: a novel approach using large-scale cancer cell line data for the identification of potential anticancer agents
Chemical Biology & Drug Design 74 (5): 439-448 (2009-11)
Trappe R; Hinrichs C; Appel U; Babel N; Reinke P; Neumayer HH; Budde K; Dreyling M; Duehrsen U; Kliem V; Schuettrumpf S; Hauser IA; Mergenthaler HG; Schlattmann P; Anagnostopoulos I; Doerken B; Riess H
Treatment of PTLD with rituximab and CHOP reduces the risk of renal graft impairment after reduction of immunosuppression
American Journal of Transplantation 9 (10): 2331-2337 (2009-10)
Mathas S; Kreher S; Meaburn KJ; Joehrens K; Lamprecht B; Assaf C; Sterry W; Kadin ME; Daibata M; Joos S; Hummel M; Stein H; Janz M; Anagnostopoulos I; Schrock E; Misteli T; Doerken B
Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma
Proceedings of the National Academy of Sciences of the United States of America 106 (14): 5831-5836 (2009-04-07)
Rehm A; Anagnostopoulos I; Gerlach K; Broemer M; Scheidereit C; Joehrens K; Huebler M; Hetzer R; Stein H; Lipp M; Doerken B; Hoepken UE
Identification of a chemokine receptor profile characteristic for mediastinal large B-cell lymphoma
International Journal of Cancer 125 (10): 2367-2374 (2009-11-15)
Hossbach J; Michalsky E; Henklein P; Jaeger M; Daniel PT; Preissner R
Inhibiting the inhibitors: retro-inverso Smac peptides
Peptides 30 (12): 2374-2379 (2009-12)
Niyazi M; Marini P; Daniel PT; Humphreys R; Jendrossek V; Belka C
Efficacy of a triple treatment with irradiation, agonistic TRAIL receptor antibodies and EGFR blockade
Strahlentherapie und Onkologie 185 (1): 8-18 (2009-01)
Janssen K; Horn S; Niemann MT; Daniel PT; Schulze-Osthoff K; Fischer U
Inhibition of the ER Ca2+ pump forces multidrug-resistant cells deficient in Bak and Bax into necrosis
Journal of Cell Science 122 (Pt 24): 4481-4491 (2009-12-15)
Schmidt A; Wiesner B; Weisshart K; Schulz K; Furkert J; Lamprecht B; Rosenthal W; Schuelein R
Use of Kaede fusions to visualize recycling of G protein-coupled receptors
Traffic 10 (1): 2-15 (2009-01)
Handrick R; Ganswindt U; Faltin H; Goecke B; Daniel PT; Budach W; Belka C; Jendrossek V
Combined action of celecoxib and ionizing radiation in prostate cancer cells is independent of pro-apoptotic Bax
Radiotherapy and Oncology 90 (3): 413-421 (2009-03)
Mathas S; Misteli T
The dangers of transcription
Cell 139 (6): 1047-1049 (2009-12-11)
2008
Wagner M; Schmelz K; Doerken B; Tamm I
Epigenetic and genetic analysis of the survivin promoter in acute myeloid leukemia
Leukemia Research 32 (7): 1054-1060 (2008-07)
Wagner M; Schmelz K; Doerken B; Tamm I
Transcriptional regulation of human survivin by early growth response (Egr)-1 transcription factor
International Journal of Cancer 122 (6): 1278-1287 (2008-03-15)
Lutz C; Massenkeil G; Nagy M; Neuburger S; Tamm I; Rosen O; Doerken B; Arnold R
A pilot study of prophylactic donor lymphocyte infusions to prevent relapse in adult acute lymphoblastic leukemias after allogeneic hematopoietic stem cell transplantation
Bone Marrow Transplantation 41 (9): 805-812 (2008-05)
Jundt F; Acikgoez O; Kwon SH; Schwarzer R; Anagnostopoulos I; Wiesner B; Mathas S; Hummel M; Stein H; Reichardt HM; Doerken B
Aberrant expression of Notch1 interferes with the B-lymphoid phenotype of neoplastic B cells in classical Hodgkin lymphoma
Leukemia 22 (8): 1587-1594 (2008-08)
Kemmner W; Wan K; Ruttinger S; Ebert B; Macdonald R; Klamm U; Moesta KT
Silencing of human ferrochelatase causes abundant protoporphyrin-IX accumulation in colon cancer
FASEB Journal 22 (2): 500-509 (2008-02)
Jundt F; Schwarzer R; Doerken B
Notch signaling in leukemias and lymphomas
Current Molecular Medicine 8 (1): 51-59 (2008-02)
Hemmati PG; Normand G; Gillissen B; Wendt J; Doerken B; Daniel PT
Cooperative effect of p21Cip1/WAF-1 and 14-3-3sigma on cell cycle arrest and apoptosis induction by p14ARF
Oncogene 27 (53): 6707-6719 (2008-12-04)
Janz M; Mathas S
The pathogenesis of classical Hodgkin's lymphoma: what can we learn from analyses of genomic alterations in Hodgkin and Reed-Sternberg cells?
Haematologica 93 (9): 1292-1295 (2008-09)
Schwarzer R; Kaiser M; Acikgoez O; Heider U; Mathas S; Preissner R; Sezer O; Doerken B; Jundt F
Notch inhibition blocks multiple myeloma cell-induced osteoclast activation
Leukemia 22 (12): 2273-2277 (2008-12)
Ellinghaus U; Rupec RA; Pabst O; Ignatius R; Foerster R; Doerken B; Jundt F
IkappaBalpha is required for marginal zone B cell lineage development
European Journal of Immunology 38 (8): 2096-2105 (2008-08)
Terwey TH; Massenkeil G; Tamm I; Hemmati PG; Neuburger S; Martus P; Doerken B; Hoelzer D; Arnold R
Allogeneic SCT in refractory or relapsed adult ALL is effective without prior reinduction chemotherapy
Bone Marrow Transplantation 42 (12): 791-798 (2008-12)
Riess H; Pelzer U; Hilbig A; Stieler J; Opitz B; Scholten T; Kauschat-Bruning D; Bramlage P; Doerken B; Oettle H
Rationale and design of PROSPECT-CONKO 004: a prospective, randomized trial of simultaneous pancreatic cancer treatment with enoxaparin and chemotherapy
BMC Cancer 8 (1): 361 (2008-12-05)
Neuburger S; Massenkeil G; Seibold M; Lutz C; TammI I; Le Coutre P; Graf B; Doerken B; Arnold R
Successful salvage treatment of disseminated cutaneous fusariosis with liposomal amphotericin B and terbinafine after allogeneic stem cell transplantation
Transplant Infectious Disease 10 (4): 290-293 (2008-07)
2007
Hildebrandt B; Mueller C; Pezzutto A; Daniel PT; Doerken B; Scholz C
Assessment of free light chains in the cerebrospinal fluid of patients with lymphomatous meningitis - a pilot study
BMC Cancer 7: 185 (2007-10-03)
Gillissen B; Essmann F; Hemmati PG; Richter A; Richter A; Oztop I; Chinnadurai G; Doerken B; Daniel PT
Mcl-1 determines the Bax dependency of Nbk/Bik-induced apoptosis
Journal of Cell Biology 179 (4): 701-715 (2007-11-19)
Choquet S; Oertel S; Leblond V; Riess H; Varoqueaux N; Doerken B; Trappe R
Rituximab in the management of post-transplantation lymphoproliferative disorder after solid organ transplantation: proceed with caution
Annals of Hematology 86(8): 599-607 (2007-05-24)
Mistry AC; Mallick R; Froehlich O; Klein JD; Rehm A; Chen G; Sands JM
The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein
Journal of Biological Chemistry 282 (41): 30097-30106 (2007-10-12)
Nickenig C; Dreyling M; Hoster E; Ludwig WD; Doerken B; Freund M; Huber C; Ganser A; Truemper L; Forstpointner R; Unterhalt M; Hiddemann W
Initial chemotherapy with mitoxantrone, chlorambucil, prednisone impairs the collection of stem cells in patients with indolent lymphomas--results of a randomized comparison by the German Low-Grade Lymphoma Study Group
Annals of Oncology 18 (1): 136-142 (2007-01)
Lietz A; Janz M; Sigvardsson M; Jundt F; Doerken B; Mathas S
Loss of bHLH transcription factor E2A activity in primary effusion lymphoma confers resistance to apoptosis
British Journal of Haematology 137 (4): 342-348 (2007-05)
Oettle H; Post S; Neuhaus P; Gellert K; Langrehr J; Ridwelski K; Schramm H; Fahlke J; Zuelke C; Burkart C; Gutberlet K; Kettner E; Schmalenberg H; Weigang-Koehler K; Bechstein WO; Niedergethmann M; Schmidt-Wolf I; Roll L; Doerken B; Riess H
Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial
JAMA: Journal of the American Medical Association 297 (3): 267-77 (2007-01-17)
Westermann J; Nguyen-Hoai T; Baldenhofer G; Hoepken UE; Lipp M; Doerken B; Pezzutto A
CCL19 (ELC) as an adjuvant for DNA vaccination: induction of a TH1-type T-cell response and enhancement of antitumor immunity
Cancer Gene Therapy 14 (6): 523-532 (2007-06)
Hoepken UE; Wengner AM; Loddenkemper C; Stein H; Heimesaat MM; Rehm A; Lipp M
CCR7 deficiency causes ectopic lymphoid neogenesis and disturbed mucosal tissue integrity
Blood 109 (3): 886-895 (2007-02-01)
Hildebrandt B; Pech M; Nicolaou A; Langrehr JM; Kurcz J; Bartels B; Miersch A; Felix R; Neuhaus P; Riess H; Doerken B; Ricke J
Interventionally implanted port catheter systems for hepatic arterial infusion of chemotherapy in patients with colorectal liver metastases: A phase II-study and historical comparison with the surgical approach
BMC Cancer 7: 69 (2007-04-24)
Subklewe M; Sebelin-Wulf K; Beier C; Lietz A; Mathas S; Doerken B; Pezzutto A
Dendritic cell maturation stage determines susceptibility to the proteasome inhibitor bortezomib
Human Immunology 68: 147-155 (2007-03-01)
Janz M; Stuehmer T; Vassilev LT; Bargou RC
Pharmacologic activation of p53-dependent and p53-independent apoptotic pathways in Hodgkin/Reed-Sternberg cells
Leukemia 21 (4): 772-779 (2007-04)
Zantl N; Weirich G; Zall H; Seiffert BM; Fischer SF; Kirschnek S; Hartmann C; Fritsch RM; Gillissen B; Daniel PT; Haecker G
Frequent loss of expression of the pro-apoptotic protein Bim in renal cell carcinoma: evidence for contribution to apoptosis resistance
Oncogene 26(49): 7038-7048 (2007-10-25)
Trappe RU; Choquet S; Reinke P; Dreyling M; Mergenthaler HG; Jaeger U; Kebelmann-Betzing C; Jonas S; Lehmkuhl H; Anagnostopoulos I; Leblond V; Hetzer R; Doerken B; Riess H; Oertel S
Salvage therapy for relapsed posttransplant lymphoproliferative disorders (PTLD) with a second progression of PTLD after upfront chemotherapy: the role of single-agent rituximab.
Transplantation 84 (12): 1708-1712 (2007-12-27)
Hildebrandt B; Machotta A; Riess H; Kerner S; Ahlers O; Haberl H; Doerken B; Kerner T
Intraoperative fresh-frozen plasma versus human albumin in craniofacial surgery - a pilot study comparing coagulation profiles in infants younger than 12 months
Thrombosis and Haemostasis 98 (1): 172-7 (2007-07)
Cayeux S; Bukarica B; Buschow C; Charo J; Bunse M; Doerken B; Blankenstein T
In vivo splenic CD11c cells downregulate CD4 T-cell response thereby decreasing systemic immunity to gene-modified tumour cell vaccine
Gene Therapy 14 (20): 1481-1491 (2007-10)
Westermann J; Kopp J; van Lessen A; Hecker AC; Baskaynak G; le Coutre P; Doehner K; Doehner H; Doerken B; Pezzutto A
Vaccination with autologous non-irradiated dendritic cells in patients with bcr/abl+ chronic myeloid leukaemia
British Journal of Haematology 137 (4): 297-306 (2007-05)
Trappe R; Riess H; Babel N; Hummel M; Lehmkuhl H; Jonas S; Anagnostopoulos I; Papp-Vary M; Reinke P; Hetzer R; Doerken B; Oertel S
Salvage chemotherapy for refractory and relapsed posttransplant lymphoproliferative disorders (PTLD) after treatment with single-agent rituximab
Transplantation 83 (7): 912-918 (2007-04-15)
2006
Oertel S; Trappe RU; Zeidler K; Babel N; Reinke P; Hummel M; Jonas S; Papp-Vary M; Subklewe M; Doerken B; Riess H; Gaertner B
Epstein-Barr viral load in whole blood of adults with posttransplant lymphoproliferative disorder after solid organ transplantation does not correlate with clinical course
Annals of Hematology 85: 478-484 (2006-04-04)
Wardelmann E; Merkelbach-Bruse S; Pauls K; Thomas N; Schildhaus HU; Heinicke T; Speidel N; Pietsch T; Buettner R; Pink D; Reichardt P; Hohenberger P
Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate
Clinical Cancer Research 12: 1743-1749 (2006-03-15)
Bhonde MR; Hanski ML; Notter M; Gillissen BF; Daniel PT; Zeitz M; Hanski C
Equivalent effect of DNA damage-induced apoptotic cell death or long-term cell cycle arrest on colon carcinoma cell proliferation and tumour growth
Oncogene 25: 165-175 (2006-01-01)
Hildebrandt B; Rau B; Loeffel J; Wust P; Nicolaou A; Gellermann J; Le Coutre P; Neuhaus P; Felix R; Wernecke KD; Doerken B; Riess H
Adjuvant chemotherapy with folinic acid and 5-fluorouracil in patients with locally advanced rectal cancer previously treated by preoperative radiochemotherapy and curative tumor resection
International Journal of Colorectal Disease 21: 582-589 (2006-09-01)
Hossini AM; Geilen CC; Fecker LF; Daniel PT; Eberle J
A novel Bcl-x splice product, Bcl-xAK, triggers apoptosis in human melanoma cells without BH3 domain
Oncogene 25: 2160-2169 (2006-04-01)
Pink D; Lindner T; Mrozek A; Kretzschmar A; Thuss-Patience PC; Doerken B; Reichardt P
Harm or benefit of hormonal treatment in metastatic low-grade endometrial stromal sarcoma: Single center experience with 10 cases and review of the literature
Gynecologic Oncology 101: 464-469 (2006-06-01)
Stuehmer T; Bargou RC
Selective pharmacologic activation of the p53-dependent pathway as a therapeutic strategy for hematologic malignancies
Cell Cycle 5: 39-42 (2006-01-01)
Janz M; Doerken B; Mathas S
Reprogramming of B lymphoid cells in human lymphoma pathogenesis
Cell Cycle 5 (10): 1057-1061 (2006-05)
Habermehl D; Kammerer B; Handrick R; Eldh T; Gruber C; Cordes N; Daniel PT; Plasswilm L; Bamberg M; Belka C; Jendrossek V
Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway
BMC Cancer 6: 14 (2006-01-17)
Mathas S; Janz M; Hummel F; Hummel M; Wollert-Wulf B; Lusatis S; Anagnostopoulos I; Lietz A; Sigvardsson M; Jundt F; Joehrens K; Bommert K; Stein H; Doerken B
Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma
Nature Immunology 7 (2): 207-215 (2006-02)
Schlereth B; Quadt C; Dreier T; Kufer P; Lorenczewski G; Prang N; Brandl C; Lippold S; Cobb K; Brasky K; Leo E; Bargou R; Murthy K; Baeuerle PA
T-cell activation and B-cell depletion in chimpanzees treated with a bispecific anti-CD19/anti-CD3 single-chain antibody construct
Cancer Immunology Immunotherapy 55: 503-514 (2006-05-01)
Grabowski P; Sturm I; Schelwies K; Maaser K; Buhr HJ; Doerken B; Zeitz M; Daniel PT; Scheruebl H
Analysis of neuroendocrine differentiation and the p53/BAX pathway in UICC stage III colorectal carcinoma identifies patients with good prognosis
International Journal of Colorectal Disease 21: 221-230 (2006-04-01)
Burek M; Maddika S; Burek CJ; Daniel PT; Schulze-Osthoff K; Los M
Apoptin-induced cell death is modulated by Bcl-2 family members and is Apaf-1 dependent
Oncogene 25: 2213-2222 (2006-04-06)
Wagner M; Schmelz K; Wuchter C; Ludwig WD; Doerken B; Tamm I
In vivo expression of survivin and its splice variant survivin-2B: Impact on clinical outcome in acute myeloid leukemia
International Journal of Cancer 119: 1291-1297 (2006-04-17)
Trappe R; Loew A; Thuss-Patience P; Doerken B; Riess H
Successful treatment of thrombocytopenia in primary antiphospholipid antibody syndrome with the anti-CD20 antibody rituximab-monitoring of antiphospholipid and anti-GP antibodies: a case report
Annals of Hematology 85: 134-135 (2006-01-01)
Wardelmann E; Merkelbach-Bruse S; Pauls K; Thomas N; Schildhaus HU; Heinicke T; Speidel N; Pietsch T; Buettner R; Pink D; Reichardt P; Hohenberger P
Author reply: Polyclonal resistance in gastrointestinal stromal tumor treated with sequential kinase inhibitors
Clinical Cancer Research 12: 6206-6207 (2006-10-15)
Sebelin K; Schulzki A; Kloetzel PM; Doerken B; Pezzutto A; Subklewe M
Impairment of circulating myeloid dendritic cells in immunosuppressed renal/pancreas transplant recipients
Transplantation 82: 779-787 (2006-09-27)
Sturm I; Stephan C; Gillissen B; Siebert R; Janz M; Radetzki S; Jung K; Loening S; Doerken B; Daniel PT
Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma
Cell Death and Differentiation 13: 619-627 (2006-04-01)
Fecker LF; Geilen CC; Tchernev G; Trefzer U; Assaf C; Kurbanov BM; Schwarz C; Daniel PT; Eberle J
Loss of proapoptotic Bcl-2-related multidomain proteins in primary melanomas is associated with poor prognosis
Journal of Investigative Dermatology 126: 1366-1371 (2006-03-09)
Westermann J; Lessen A; Schlimper C; Baskaynak G; Coutre P; Doerken B; Pezzutto A
Simultaneous cytokine analysis by cytometric bead array for the detection of leukaemia-reactive T cells in patients with chronic myeloid leukaemia
British Journal of Haematology 132: 32-35 (2006-01-01)
Marini P; Denzinger S; Schiller D; Kauder S; Welz S; Humphreys R; Daniel PT; Jendrossek V; Budach W; Belka C
Combined treatment of colorectal tumours with agonistic TRAIL receptor antibodies HGS-ETR1 and HGS-ETR2 and radiotherapy: enhanced effects in vitro and dose-dependent growth delay in vivo
Oncogene 25: 5145-5154 (2006-08-24)
Schmitz N; Kloess M; Reiser M; Berdel WE; Metzner B; Doerken B; Kneba M; Trumper L; Loeffler M; Pfreundschuh M; Glass B
Four versus six courses of a dose-escalated cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen plus etoposide (megaCHOEP) and autologous stem cell transplantation
Cancer 106: 136-145 (2006-01-01)
Sturm I; Bosanquet AG; Radetzki S; Hummel M; Doerken B; Daniel PT
Silencing of APAF-1 in B-CLL results in poor prognosis in the case of concomitant p53 mutation
International Journal of Cancer 118: 2329-2336 (2006-05-01)
Sturm I; Rau B; Schlag PM; Wust P; Hildebrandt B; Riess H; Hauptmann S; Doerken B; Daniel PT
Genetic dissection of apoptosis and cell cycle control in response of colorectal cancer treated with preoperative radiochemotherapy
BMC Cancer 6: 124 (2006-05-10)
Hemmati PG; Guener D; Gillissen B; Wendt J; von Haefen C; Chinnadurai G; Doerken B; Daniel PT
Bak functionally complements for loss of Bax during p14(ARF)-induced mitochondrial apoptosis in human cancer cells
Oncogene 25 (50): 6582-6594 (2006-10-26)
Bhonde MR; Hanski ML; Budczies J; Cao M; Gillissen B; Moorthy D; Simonetta F; Scheruebl H; Truss M; Hagemeier C; Mewes HW; Daniel PT; Zeitz M; Hanski C
DNA damage-induced expression of p53 suppresses mitotic checkpoint kinase hMps1: the lack of this suppression in p53MUT cells contributes to apoptosis
Journal of Biological Chemistry 281: 8675-8685 (2006-03-31)
Hu H; Jiang C; Schuster T; Li GX; Daniel PT; Lue J
Inorganic selenium sensitizes prostate cancer cells to TRAIL-induced apoptosis through superoxide/p53/Bax-mediated activation of mitochondrial pathway
Molecular Cancer Therapeutics 5: 1873-1882 (2006-07-01)
Wendt J; Radetzki S; von Haefen C; Hemmati PG; Guener D; Schulze-Osthoff K; Doerken B; Daniel PT
Induction of p21CIP/WAF-1 and G2 arrest by ionizing irradiation impedes caspase-3-mediated apoptosis in human carcinoma cells
Oncogene 25: 972-980 (2006-02-16)
2005
Bhonde MR; Hanski ML; Magrini R; Moorthy D; Mueller A; Sausville EA; Kohno K; Wiegand P; Daniel PT; Zeitz M; Hanski C
The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-xL protein
Oncogene 24: 148-156 (2005-01-06)
Essmann F; Pohlmann S; Gillissen B; Daniel PT; Schulze-Osthoff K; Jaenicke RU
Irradiation-induced translocation of p53 to mitochondria in the absence of apoptosis
Journal of Biological Chemistry 280: 37169-37177 (2005-11-04)
Holdhoff M; Kreuzer KA; Appelt C; Scholz R; Na IK; Hildebrandt B; Riess H; Jordan A; Schmidt CA; Van Etten RA; Doerken B; LeCoutre P
Imatinib mesylate radiosensitizes human glioblastoma cells through inhibition of platelet-derived growth factor receptor
Blood Cells Molecules and Diseases 34: 181-185 (2005-01-01)
Chandra D; Choy G; Daniel PT; Tang DG
Bax-dependent regulation of Bak by voltage-dependent anion channel 2
Journal of Biological Chemistry 280: 19051-19061 (2005-01-01)
Wendt J; von Haefen C; Hemmati P; Belka C; Doerken B; Daniel PT
TRAIL sensitizes for ionizing irradiation-induced apoptosis through an entirely Bax-dependent mitochondrial cell death pathway
Oncogene 24: 4052-4064 (2005-01-01)
Rudner J; Jendrossek V; Lauber K; Daniel PT; Wesselborg S; Belka C
Type I and type II reactions in TRAIL-induced apoptosis - results from dose-response studies
Oncogene 24: 130-140 (2005-01-06)
Rueder C; Reimer T; Delgado-Martinez I; Hermosilla R; Engelsberg A; Nehring R; Doerken B; Rehm A
EBAG9 adds a new layer of control on large dense-core vesicle exocytosis via interaction with Snapin
Molecular Biology of the Cell 16 (3): 1245-1257 (2005-01-05)
Braig M; Lee S; Loddenkemper C; Rudolph C; Peters AH; Schlegelberger B; Stein H; Doerken B; Jenuwein T; Schmitt CA
Oncogene-induced senescence as an initial barrier in lymphoma development
Nature 436 (7051): 660-665 (2005-08-04)
Massenkeil G; Nagy M; Neuburger S; Tamm I; Lutz C; Le Coutre P; Rosen O; Wernecke KD; Doerken B; Arnold R
Survival after reduced-intensity conditioning is not inferior to standard high-dose conditioning before allogeneic haematopoietic cell transplantation in acute leukaemias
Bone Marrow Transplantation 36: 683-689 (2005-08-22)
Staerck L; Scholz C; Blankenstein T; Doerken B; Daniel PT
Necrotic death but not irradiation abolishes costimulation of T-cell effector functions and survival by CD80-expressing tumor cells
International Journal of Cancer 116: 78-86 (2005-01-01)
Reich G; Cornely OA; Sandherr M; Kubin T; Krause S; Einsele H; Thiel E; Bellaire T; Doerken B; Maschmeyer G
Empirical antimicrobial monotherapy in patients after high-dose chemotherapy and autologous stem cell transplantation: a randomised, multicentre trial
British Journal of Haematology 130: 265-270 (2005-07-01)
Josting A; Sieniawski M; Glossmann JP; Staak O; Nogova L; Peters N; Mapara M; Doerken B; Ko Y; Metzner B; Kisro J; Diehl V; Engert A
High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study
Annals of Oncology 16: 1359-1365 (2005-01-01)
Bergmann S; Royer-Pokora B; Fietze E; Juerchott K; Hildebrandt B; Trost D; Leenders F; Claude JC; Theuring F; Bargou R; Dietel M; Royer HD
YB-1 provokes breast cancer through the induction of chromosomal instability that emerges from mitotic failure and centrosome amplification
Cancer Research 65: 4078-4087 (2005-01-01)
Helmrich A; Lee S; O'Brien P; Doerken B; Lowe SW; Schroeck E; Schmitt CA
Recurrent chromosomal aberrations in INK4a/ARF defective primary lymphomas predict drug responses in vivo
Oncogene 24: 4174-4182 (2005-01-01)
Normand G; Hemmati PG; Verdoodt B; von Haefen C; Wendt J; Guener D; May E; Doerken B; Daniel PT
p14ARF induces G2 cell cycle arrest in p53- and p21-deficient cells by down-regulating p34cdc2 kinase activity
Journal of Biological Chemistry 280: 7118-7130 (2005-01-01)
Josting A; Rudolph C; Mapara M; Glossmann JP; Sienawski M; Sieber M; Kirchner HH; Doerken B; Hossfeld DK; Kisro J; Metzner B; Berdel WE; Diehl V; Engert A
Cologne high-dose sequential chemotherapy in relapsed and refractory Hodgkin lymphoma: results of a large multicenter study of the German Hodgkin Lymphoma Study Group (GHSG)
Annals of Oncology 16: 116-123 (2005-01-01)
Staerck L; Scholz C; Doerken B; Daniel PT
Costimulation by CD137/4-1BB inhibits T cell apoptosis and induces Bcl-xL and c-FLIPshort via phosphatidylinositol 3-kinase and AKT/protein kinase B
European Journal of Immunology 35: 1257-1266 (2005-01-01)
Hemmati PG; Normand G; Verdoodt B; von Haefen C; Hasenjaeger A; Guener D; Wendt J; Doerken B; Daniel PT
Loss of p21 disrupts p14ARF-induced G1 cell cycle arrest but augments p14ARF-induced apoptosis in human carcinoma cells
Oncogene 24: 4114-4128 (2005-01-01)
Hoffmann P; Hofmeister R; Brischwein K; Brandl C; Crommer S; Bargou R; Itin C; Prang N; Baeuerle PA
Serial killing of tumor cells by cytotoxic T cells redirected with a CD19-/CD3-bispecific single-chain antibody construct
International Journal of Cancer 115: 98-104 (2005-01-01)
Scholz C; Richter A; Lehmann M; Schulze-Osthoff K; Doerken B; Daniel PT
Arsenic trioxide induces regulated, death receptor-independent cell death through a Bcl-2-controlled pathway
Oncogene 24: 7031-7042 (2005-10-27)
Na IK; Kreuzer KA; Lupberger J; Doerken B; Coutre P
Quantitative RT-PCR of Wilms tumor gene transcripts (WT1) for the molecular monitoring of patients with accelerated phase bcr/abl + CML
Leukemia Research 29: 343-345 (2005-01-01)
Scholz C; Nimmrich I; Burger M; Becker E; Doerken B; Ludwig WD; Maier S
Distinction of acute lymphoblastic leukemia from acute myeloid leukemia through microarray-based DNA methylation analysis
Annals of Hematology 84: 236-244 (2005-01-01)
Schmelz K; Wagner M; Doerken B; Tamm I
5-Aza-2'-deoxycytidine induces p21WAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia
International Journal of Cancer 114: 683-695 (2005-05-01)
Scholz C; Wieder T; Staerck L; Essmann F; Schulze-Osthoff K; Doerken B; Daniel PT
Arsenic trioxide triggers a regulated form of caspase-independent necrotic cell death via the mitochondrial death pathway
Oncogene 24: 1904-1913 (2005-01-01)
Hoepken UE; Lehmann I; Droese J; Lipp M; Schueler T; Rehm A
The ratio between dendritic cells and T cells determines the outcome of their encounter: Proliferation versus deletion
European Journal of Immunology 35: 2851-2863 (2005-09-23)
Oppermann M; Geilen CC; Fecker LF; Gillissen B; Daniel PT; Eberle J
Caspase-independent induction of apoptosis in human melanoma cells by the proapoptotic Bcl-2-related protein Nbk/Bik
Oncogene 24: 7369-7380 (2005-07-04)
Schmelz K; Sattler N; Wagner M; Luebbert M; Doerken B; Tamm I
Induction of gene expression by 5-Aza-2'-deoxycytidine in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) but not epithelial cells by DNA-methylation-dependent and -independent mechanisms
Leukemia 19: 103-111 (2005-01-01)
Oertel SH; Verschuuren E; Reinke P; Zeidler K; Papp-Vary M; Babel N; Trappe RU; Jonas S; Hummel M; Anagnostopoulos I; Doerken B; Riess HB
Effect of anti-CD 20 antibody rituximab in patients with post-transplant lymphoproliferative disorder (PTLD)
American Journal of Transplantation 5: 2901-2906 (2005-12-01)
2004
Hoenemann D; Kufer P; Rimpler MM; Chatterjee M; Friedl S; Riecher F; Bommert K; Doerken B; Bargou RC
A novel recombinant bispecific single-chain antibody, bscWue-1 x CD3, induces T-cell-mediated cytotoxicity towards human multiple myeloma cells
Leukemia 18: 636-644 (2004-01-01)
Loddenkemper C; Anagnostopoulos L; Hummel M; Joehrens-Leder K; Foss HD; Jundt F; Wirth T; Doerken B; Stein H
Differential Emu enhancer activity and expression of BOB.1/OBF.1, Oct2, PU.1, and immunoglobulin in reactive B-cell populations, B-cell non-Hodgkin lymphomas, and Hodgkin lymphomas
Journal of Pathology 202: 60-69 (2004-01-01)
Westermann J; Schlimper C; Richter G; Mohm J; Doerken B; Pezzutto A
T cell recognition of bcr/abl in healthy donors and in patients with chronic myeloid leukaemia
British Journal of Haematology 125: 213-216 (2004-04-01)
Arce S; Luger E; Muehlinghaus G; Cassese G; Hauser A; Horst A; Lehnert K; Odendahl M; Hoenemann D; Heller KD; Kleinschmidt H; Berek C; Doerner T; Krenn V; Hiepe F; Bargou R; Radbruch A; Manz RA
CD38 low IgG-secreting cells are precursors of various CD38 high-expressing plasma cell populations
Journal of Leukocyte Biology 75: 1022-1028 (2004-01-01)
Chandra D; Choy G; Deng X; Bhatia B; Daniel P; Tang DG
Association of active caspase 8 with the mitochondrial membrane during apoptosis: potential roles in cleaving BAP31 and caspase 3 and mediating mitochondrion-endoplasmic reticulum cross talk in etoposide-induced cell death
Molecular and Cellular Biology 24: 6592-6607 (2004-01-01)
Kreuzer KA; Kluehs C; Baskaynak G; Movassaghi K; Doerken B; Le Coutre P
Filgrastim-induced stem cell mobilization in chronic myeloid leukaemia patients during imatinib therapy: safety, feasibility and evidence for an efficient in vivo purging
British Journal of Haematology 124: 195-199 (2004-01-01)
Schories B; Engel K; Doerken B; Gossen M; Bommert K
Characterization of apoptosis-induced Mcm3 and Cdc6 cleavage reveals a proapoptotic effect for one Mcm3 fragment
Cell Death and Differentiation 11: 940-942 (2004-08-01)
Le Coutre P; Kreuzer KA; Pursche S; Bonin M; Leopold T; Baskaynak G; Doerken B; Ehninger G; Ottmann O; Jenke A; Bornhaeuser M; Schleyer E
Pharmacokinetics and cellular uptake of imatinib and its main metabolite CGP74588
Cancer Chemotherapy and Pharmacology 53: 313-323 (2004-04-01)
Massenkeil G; Roigas J; Nagy M; Wille A; Stroszczynski C; Mapara MY; Loening S; Doerken B; Arnold R
Nonmyeloablative stem cell transplantation in metastatic renal cell carcinoma: delayed graft-versus-tumor effect is associated with chimerism conversion but transplantation has high toxicity
Bone Marrow Transplantation 34: 309-316 (2004-08-01)
Schories B; Janz M; Doerken B; Bommert K
Downregulation of genes involved in DNA repair and differential expression of transcription regulators and phosphatases precede IgM-induced apoptosis in the Burkitt's lymphoma cell line BL60-2
Biochimica et Biophysica Acta - Gene Structure and Expression 1676: 83-95 (2004-01-01)
Kloepfer A; Hasenjaeger A; Belka C; Schulze-Osthoff K; Doerken B; Daniel PT
Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathway
Oncogene 23: 9408-9418 (2004-01-01)
Lee S; Doerken B; Schmitt CA
Extracorporeal photopheresis in graft-versus-host disease: ultraviolet radiation mediates T cell senescence in vivo
Transplantation 78: 484-485 (2004-01-01)
Schmelz K; Wieder T; Tamm I; Mueller A; Essmann F; Geilen CC; Schulze-Osthoff K; Doerken B; Daniel PT
Tumor necrosis factor alpha sensitizes malignant cells to chemotherapeutic drugs via the mitochondrial apoptosis pathway independently of caspase-8 and NF-kappaB
Oncogene 23: 6743-6759 (2004-09-02)
Westermann J; Nguyen-Hoai T; Mollweide A; Richter G; Schmetzer O; Kim HJ; Blankenstein T; Doerken B; Pezzutto A
Flt-3 ligand as adjuvant for DNA vaccination augments immune responses but does not skew TH1/TH2 polarization
Gene Therapy 11: 1048-1056 (2004-01-01)
von Haefen C; Gillissen B; Hemmati PG; Wendt J; Guener D; Mrozek A; Belka C; Doerken B; Daniel PT
Multidomain Bcl-2 homolog Bax but not Bak mediates synergistic induction of apoptosis by TRAIL and 5-FU through the mitochondrial apoptosis pathway
Oncogene 23: 8320-8332 (2004-09-27)
Subklewe M; Nagy M; Schoch C; Jenisch S; Siebert R; Gesk S; Neuhaus P; Doerken B; Schmidt CA
Extramedullary manifestation of a donor-derived acute myeloid leukemia in a liver transplant patient
Leukemia 18: 2050-2053 (2004-10-07)
Droese J; Mokros T; Hermosilla R; Schuelein R; Lipp M; Hoepken UE; Rehm A
HCMV-encoded chemokine receptor US28 employs multiple routes for internalization
Biochemical and Biophysical Research Communications 322: 42-49 (2004-09-10)
Jundt F; Schulze Proebsting K; Anagnostopoulos I; Muehlinghaus G; Chatterjee M; Mathas S; Bargou RC; Manz R; Stein H; Doerken B
Jagged1-induced notch signaling drives proliferation of multiple myeloma cells
Blood 103: 3511-3515 (2004-01-01)
Gruen M; Bommert K; Bargou RC
T-cell-mediated lysis of B cells induced by a CD19xCD3 bispecific single-chain antibody is perforin dependent and death receptor independent
Cancer Immunology Immunotherapy 53: 625-632 (2004-01-01)
Chatterjee M; Stuehmer T; Herrmann P; Bommert K; Doerken B; Bargou RC
Combined disruption of both the MEK/ERK and the IL-6R/STAT3 pathways is required to induce apoptosis of multiple myeloma cells in the presence of bone marrow stromal cells
Blood 104: 3712-3721 (2004-01-01)
Lentzsch S; Chatterjee M; Gries M; Bommert K; Gollasch H; Doerken B; Bargou RC
PI3-K/AKT/FKHR and MAPK signaling cascades are redundantly stimulated by a variety of cytokines and contribute independently to proliferation and survival of multiple myeloma cells
Leukemia 18: 1883-1890 (2004-01-01)
Hasenjaeger A; Gillissen B; Mueller A; Normand G; Hemmati PG; Schuler M; Doerken B; Daniel PT
Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-xL in a strictly caspase-3-dependent manner in human carcinoma cells
Oncogene 23: 4523-4535 (2004-06-03)
2003
Mrozek A; Petrowsky H; Sturm I; Kraus J; Hermann S; Hauptmann S; Lorenz M; Doerken B; Daniel PT
Combined p53/Bax mutation results in extremely poor prognosis in gastric carcinoma with low microsatellite instability
Cell Death and Differentiation 10: 461-467 (2003-04-01)
Reichardt P; Oechsle K; Pink D; Bokemeyer C; Schneller F; Issels R; Kanz L; Hartmann JT
An open label, non-comparative phase II study of topotecan as salvage treatment for patients with soft tissue sarcoma
Investigational New Drugs 21: 481-486 (2003-11-01)
Maier M; Maier-Bosse T; Schulz CU; Steinborn M; Schmitt CA; Kleen M; Staebler A
Inter and intraobserver variability in DePalma's classification of shoulder calcific tendinitis
Journal of Rheumatology 30: 1029-1031 (2003-01-01)
Emmerich F; Theurich S; Hummel M; Haeffker A; Vry MS; Doehner K; Bommert K; Stein H; Doerken B
Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells
Journal of Pathology 201: 413-420 (2003-01-01)
Wolff G; Schumacher A; Nuessler AK; Ruppert V; Karawajew L; Wehnes E; Neuhaus P; Doerken B
Coexpression of p21WAF1/CIP1 in adenovirus vector transfected human primary hepatocytes prevents apoptosis resulting in improved transgene expression
Gene Therapy 10 (8): 668-677 (2003-01-01)
Diehl V; Franklin J; Pfreundschuh M; Lathan B; Paulus U; Hasenclever D; Tesch H; Herrmann R; Doerken B; Mueller-Hermelink HK; Duehmke E; Loeffler M
Standard and increased-dose BEACOPP chemotherapy compared with COPP-ABVD for advanced Hodgkins disease
New England Journal of Medicine 348 (24): 2386-2395 (2003-06-12)
von Haefen C; Wieder T; Essmann F; Schulze-Osthoff K; Doerken B; Daniel PT
Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop
Oncogene 22: 2236-2247 (2003-04-01)
Reichardt P; Lindner T; Pink D; Thuss-Patience PC; Kretzschmar A; Doerken B
Chemotherapy in alveolar soft part sarcomas: What do we know?
European Journal of Cancer 39: 1511-1516 (2003-07-01)
Sturm I; Bosanquet AG; Hermann S; Guener D; Doerken B; Daniel PT
Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy
Cell Death and Differentiation 10: 477-484 (2003-04-01)
Schlenk RF; Benner A; Hartmann F; del Valle F; Weber C; Pralle H; Fischer JT; Gunzer U; Pezzutto A; Weber W; Grimminger W; Preiss J; Hensel M; Froehling S; Doehner K; Haas R; Doehner H
Risk-adapted postremission therapy in acute myeloid leukemia: results of the German multicenter AML HD93 treatment trial
Leukemia 17: 1521-1528 (2003-08-01)
Benter T; Kluhs L; Teichgraber UK; Riechert F; Ludwig WD; Doerken B
Need for safety goggles for endoscopy
Endoscopy 35: 803 (2003-09-01)
Prokop A; Wrasidlo W; Lode H; Herold R; Lang F; Henze G; Doerken B; Wieder T; Daniel PT
Induction of apoptosis by enediyne antibiotic calicheamicin gammaII proceeds through a caspase-mediated mitochondrial amplification loop in an entirely Bax-dependent manner
Oncogene 22: 9107-9120 (2003-12-11)
Guener D; Sturm I; Hemmati P; Hermann S; Hauptmann S; Wurm R; Budach V; Doerken B; Lorenz M; Daniel PT
Multigene analysis of Rb pathway and apoptosis control in esophageal squamous cell carcinoma identifies patients with good prognosis
International Journal of Cancer 103: 445-454 (2003-02-10)
Loeffler A; Gruen M; Wuchter C; Schriever F; Kufer P; Dreier T; Hanakam F; Baeuerle PA; Bommert K; Karawajew L; Doerken B; Bargou RC
Efficient elimination of chronic lymphocytic leukaemia B cells by autologous T cells with a bispecific anti-CD19/anti-CD3 single-chain antibody construct
Leukemia 17: 900-909 (2003-01-01)
Engelsberg A; Hermosilla R; Karsten U; Schuelein R; Doerken B; Rehm A
The Golgi protein RCAS1 controls cell surface expression of tumor-associated O-linked glycan antigens
Journal of Biological Chemistry 278: 22998-23007 (2003-01-01)
Naumann U; Schmidt F; Wick W; Frank B; Weit S; Gillissen B; Daniel P; Weller M
Adenoviral natural born killer gene therapy for malignant glioma
Human Gene Therapy 14: 1235-1246 (2003-01-01)
Schmitt CA
Senescence apoptosis and therapy - cutting the lifelines of cancer
Nature Reviews Cancer 3 (4): 286-295 (2003-01-01)
Mapara MY; Kim YM; Marx J; Sykes M
Donor lymphocyte infusion-mediated graft-versus-leukemia effects in mixed chimeras established with a nonmyeloablative conditioning regimen: extinction of graft-versus-leukemia effects after conversion to full donor chimerism
Transplantation 76: 297-305 (2003-07-27)
Daniel PT; Schulze-Osthoff K; Belka C; Guener D
Guardians of cell death: the Bcl-2 family proteins
Essays in Biochemistry 39: 73-88 (2003-01-01)
Kern W; Danhauser-Riedl S; Ratei R; Schnittger S; Schoch C; Kolb HJ; Ludwig WD; Hiddemann W; Haferlach T
Detection of minimal residual disease in unselected patients with acute myeloid leukemia using multiparameter flow cytometry for definition of leukemia-associated immunophenotypes and determination of their frequencies in normal bone marrow
Haematologica 88: 646-653 (2003-06-01)
Lentzsch S; LeBlanc R; Podar K; Davies F; Lin B; Hideshima T; Catley L; Stirling DI; Anderson KC
Immunomodulatory analogs of thalidomide inhibit growth of Hs Sultan cells and angiogenesis in vivo
Leukemia 17: 41-44 (2003-01-01)
Denkert C; Fuerstenberg A; Daniel PT; Koch I; Koebel M; Weichert W; Siegert A; Hauptmann S
Induction of G0/G1 cell cycle arrest in ovarian carcinoma cells by the anti-inflammatory drug NS-398, but not by COX-2-specific RNA interference
Oncogene 22: 8653-8661 (2003-11-27)
Dreier T; Baeuerle PA; Fichtner I; Gruen M; Schlereth B; Lorenczewski G; Kufer P; Lutterbuese R; Riethmueller G; Gjorstrup P; Bargou RC
T cell costimulus-independent and very efficacious inhibition of tumor growth in mice bearing subcutaneous or leukemic human B cell lymphoma xenografts by a CD19-/CD3-bispecific single-chain antibody construct1
Journal of Immunology 170 (8): 4397-4402 (2003-01-01)
Westermann J; Koerner IJ; Kopp J; Kurz S; Zenke M; Doerken B; Pezzutto A
Cryopreservation of mature monocyte-derived human dendritic cells for vaccination: influence on phenotype and functional properties
Cancer Immunology Immunotherapy 52 (3): 194-198 (2003-01-01)
Eberle J; Fecker LF; Hossini AM; Wieder T; Daniel PT; Orfanos CE; Geilen CC
CD95/Fas signaling in human melanoma cells: conditional expression of CD95L/FasL overcomes the intrinsic apoptosis resistance of malignant melanoma and inhibits growth and progression of human melanoma xenotransplants
Oncogene 22: 9131-9141 (2003-12-11)
2002
Borkhardt A; Wuchter C; Viehmann S; Pils S; Teigler-Schlegel A; Stanulla M; Zimmermann M; Ludwig WD; Janka-Schaub G; Schrappe M; Harbott J
Infant acute lymphoblastic leukemia - combined cytogenetic, immunophenotypical and molecular analysis of 77 cases
Leukemia 16, 9: 1685-1690 (2002-09-01)
Jundt F; Kley K; Anagnostopoulos I; Schulze-Probsting K; Greiner A; Mathas S; Scheidereit C; Wirth T; Stein H; Doerken B
Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease
Blood 99: 3060-3062 (2002-04-15)
Wuchter C; Ruppert V; Schrappe M; Doerken B; Ludwig WD; Karawajew L
In vitro susceptibility to dexamethasone- and doxorubicin-induced apoptotic cell death in context of maturation stage, responsiveness to interleukin 7, and early cytoreduction in vivo in childhood T-cell acute lymphoblastic leukemia
Blood 99: 4109-4115 (2002-06-01)
Josting A; Rudolph C; Reiser M; Mapara M; Sieber M; Kirchner HH; Doerken B; Hossfeld DK; Diehl V; Engert A; Participating Ctr
Time-intensified dexamethasone/cisplatin/cytarabine: an effective salvage therapy with low toxicity in patients with relapsed and refractory Hodgkin's disease
Annals of Oncology 13: 1628-1635 (2002-01-01)
Radetzki S; Koehne CH; von Haefen C; Gillissen B; Sturm I; Doerken B; Daniel PT
The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr-1-negative and Mdr-1-overexpressing breast cancer cell lines
Oncogene 21: 227-238 (2002-01-10)
Mokros T; Rehm A; Droese J; Oppermann M; Lipp M; Hoepken UE
Surface expression and endocytosis of the human cytomegalovirus-encoded chemokine receptor US28 is regulated by agonist-independent phosphorylation
Journal of Biological Chemistry 277: 45122-45128 (2002-01-01)
Dreier T; Lorenczewski G; Brandl C; Hoffmann P; Syring U; Hanakam F; Kufer P; Riethmuller G; Bargou R; Baeuerle PA
Extremely potent, rapid and costimulation-independent cytotoxic T-cell response against lymphoma cells catalyzed by a single-chain bispecific antibody
International Journal of Cancer 100: 690-697 (2002-01-01)
Chatterjee M; Hoenemann D; Lentzsch S; Bommert K; Sers C; Herrmann P; Mathas S; Doerken B; Bargou RC
In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6/gp 130/STAT3 pathway
Blood 100: 3311-3318 (2002-01-01)
Hemmati PG; Gillissen B; von Haefen C; Wendt J; Staerck L; Guener D; Doerken B; Daniel PT
Adenovirus-mediated overexpression of p14ARF induces p53 and Bax-independent apoptosis
Oncogene 21: 3149-3161 (2002-05-09)
Papadopoulos S; Benter T; Anastassiou G; Pape M; Gerhard S; Bornfeld N; Ludwig WD; Doerken B
Assessment of genomic instability in breast cancer and uveal melanoma by random amplified polymorphic DNA analysis
International Journal of Cancer 99: 193-200 (2002-05-10)
Grinstein E; Jundt F; Weinert I; Wernet P; Royer HD
Sp1 as G1 cell cycle phase specific transcription factor in epithelial cells
Oncogene 21: 1485-1492 (2002-01-01)
Maywald O; Metzgeroth G; Schoch C; Ludwig WD; Neff W; Hehlmann R; Hastka J
Alveolar rhabdomyosarcoma with bone marrow infiltration mimicking haematological neoplasia
British Journal of Haematology 119: 583 (2002-12-01)
Tamm I; Schumacher A; Karawajew L; Ruppert V; Arnold W; Nuessler AK; Neuhaus P; Doerken B; Wolff G
Adenovirus-mediated gene transfer of P161NK4/CDKN2 into bax-negative colon cancer cells induces apoptosis and tumor regression in vivo
Cancer Gene Therapy 9: 641-650 (2002-01-01)
Bosanquet AG; Sturm I; Wieder T; Essmann F; Bosanquet MI; Head FJ; Doerken B; Daniel PT
Bax expression correlates with cellular drug sensitivity to doxorubicin, cyclophosphamide and chlorambucil but not fludarabine, cladribine or corticosteroids in B cell chronic lymphocytic leukemia
Leukemia 16 (6): 1035-1044 (2002-01-01)
von Haefen C; Wieder T; Gillissen B; Starck L; Graupner V; Doerken B; Daniel PT
Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells
Oncogene 21: 4009-4019 (2002-06-06)
LeBlanc R; Catley LP; Hideshima T; Lentzsch S; Mitsiades CS; Mitsiades N; Neuberg D; Goloubeva O; Pien CS; Adams J; Gupta D; Richardson PG; Munshi NC; Anderson KC
Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model
Cancer Research 62 (17): 4996-5000 (2002-09-01)
Kern W; Haferlach T; Schnittger S; Ludwig WD; Hiddemann W; Schoch C
Karyotype instability between diagnosis and relapse in 117 patients with acute myeloid leukemia: implications for resistance against therapy
Leukemia 16, 10: 2084-2091 (2002-10-01)
Schmitt CA; Fridman JS; Yang M; Lee S; Baranov E; Hoffman RM; Lowe SW
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
Cell 109: 335-346 (2002-05-03)
Schelwies K; Sturm I; Grabowski P; Scherubl H; Schindler I; Hermann S; Stein H; Buhr HJ; Riecken EO; Zeitz M; Doerken B; Daniel PT
Analysis of p53/BAX in primary colorectal carcinoma: low BAX protein expression is a negative prognostic factor in UICC stage III tumors
International Journal of Cancer 99: 589-596 (2002-06-01)
Lentzsch S; Rogers MS; LeBlanc R; Birsner AE; Shah JH; Treston AM; Anderson KC; D'Amato RJ
S-3-Amino-phthalimido-glutarimide inhibits angiogenesis and growth of B-cell neoplasias in mice
Cancer Research 62: 2300-2305 (2002-04-15)
Oertel J; Kingreen D; Busemann C; Stein H; Doerken B
Morphologic diagnosis of leukaemic B-lymphoproliferative disorders and the role of cyclin D1 expression
Journal of Cancer Research and Clinical Oncology 128: 182-188 (2002-04-01)
Scholz C; Staerck L; Willimsky G; Blankenstein T; Doerken B; Daniel PT
Adenoviral transduction of tumor cells induces apoptosis in co-cultured T lymphocytes
Gene Therapy 9: 1438-1446 (2002-01-01)
Schmitt CA; Lowe SW
Apoptosis and chemoresistance in transgenic cancer models
Journal of Molecular Medicine 80 (3): 137-146 (2002-01-01)
Mapara MY; Kim YM; Wang SP; Bronson R; Sachs DH; Sykes M
Donor lymphocyte infusions mediate superior graft-versus-leukemia effects in mixed compared to fully allogeneic chimeras: a critical role for host antigen-presenting cells
Blood 100: 1903-1909 (2002-09-01)
Janz M; Harbeck N; Dettmar P; Berger U; Schmidt A; Juerchott K; Schmitt M; Royer HD
Y-box factor YB-1 predicts drug resistance and patient outcome in breast cancer independent of clinically relevant tumor biologic factors HER2, uPA and PAI-1
International Journal of Cancer 97: 278-282 (2002-01-01)
Jundt F; Anagnostopoulos I; Foerster R; Mathas S; Stein H; Doerken B
Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma
Blood 99 (9): 3398-3403 (2002-01-01)
Lin B; Podar K; Gupta D; Tai YT; Li S; Weller E; Hideshima T; Lentzsch S; Davies F; Li C; Weisberg E; Schlossman RL; Richardson PG; Griffin JD; Wood J; Munshi NC; Anderson KC
The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment
Cancer Research 62: 5019-5026 (2002-09-01)
2001
Podar K; Tai YT; Davies FE; Lentzsch S; Sattler M; Hideshima T; Lin BK; Gupta D; Shima Y; Chauhan D; Mitsiades C; Raje N; Richardson P; Anderson KC
Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration
Blood 98 (2): 428-435 (2001-07-15)
Westermann J; Reich G; Kopp J; Haus U; Doerken D; Pezzutto A
Granulocyte/macrophage-colony-stimulating-factor plus interleukin-2 plus interferon alpha in the treatment of metastatic renal cell carcinoma: a pilot study
Cancer Immunology Immunotherapy 49: 613-620 (2001-01-01)
Buechner T; Hiddemann W; Berdel W; Woermann B; Loeffler H; Schoch C; Haferlach T; Ludwig WD; Maschmeyer G; Staib P; Andreesen R; Balleisen L; Haase D; Eimermacher H; Aul C; Rasche H; Uhlig J; Grueneisen A; Reis HE; Hartlapp J; Hirschmann WD; Weh HJ; Pielken HJ; Gassmann W; Sauerland MC; Heinecke A
Remission induction therapy: the more intensive the better?
Cancer Chemotherapy and Pharmacology 48 Suppl 1: S41-S44 (2001-08-01)
Badock V; Steinhusen U; Bommert K; Wittmann-Liebold B; Otto A
Apoptosis-induced cleavage of keratin 15 and keratin 17 in a human breast epithelial cell line
Cell Death and Differentiation 8: 308-315 (2001-03-01)
Daniel PT; Wieder T; Sturm I; Schulze-Osthoff K
The kiss of death: promises and failures of death receptors and ligands in cancer therapy
Leukemia 15: 1022-1032 (2001-07-01)
Gupta D; Treon SP; Shima Y; Hideshima T; Podar K; Tai YT; Lin B; Lentzsch S; Davies FE; Chauhan D; Schlossman RL; Richardson P; Ralph P; Wu L; Payvandi F; Muller G; Stirling DI; Anderson KC
Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications
Leukemia 15: 1950-1961 (2001-12-01)
Cai Z; Lin M; Wuchter C; Ruppert V; Doerken B; Ludwig WD; Karawajew L
Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation
Leukemia 15: 567-574 (2001-01-01)
Hinz M; Loeser P; Mathas S; Krappmann D; Doerken B; Scheidereit C
Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells
Blood 97: 2798-2807 (2001-01-01)
Hilgenfeld E; Padilla-Nash H; McNeil N; Knutsen T; Montagna C; Tchinda J; Horst J; Ludwig WD; Serve H; Buechner T; Berdel WE; Schroeck E; Ried T
Spectral karyotyping and fluorescence in situ hybridization detect novel chromosomal aberrations, a recurring involvement of chromosome 21 and amplification of the MYC oncogene in acute myeloid leukaemia M2
British Journal of Haematology 113: 305-317 (2001-05-01)
Davies FE; Raje N; Hideshima T; Lentzsch S; Young G; Tai YT; Lin B; Podar K; Gupta D; Chauhan D; Treon SP; Richardson PG; Schlossman RL; Morgan GJ; Muller GW; Stirling DI; Anderson KC
Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma
Blood 98 (1): 210-216 (2001-07-01)
Reich G; Held T; Siegert W; Kampf D; Doerken B; Maschmeyer G
Four patients with AL amyloidosis treated with high-dose chemotherapy and autologous stem cell transplantation
Bone Marrow Transplantation 27: 341-343 (2001-02-01)
Friedrich K; Wieder T; von Haefen C; Radetzki S; Jaenicke R; Schulze-Osthoff K; Doerken B; Daniel PT
Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance
Oncogene 20: 2749-2760 (2001-05-17)
Cayeux S; Qin ZH; Doerken B; Blankenstein T
Decreased generation of anti-tumor immunity after intrasplenic immunization
European Journal of Immunology 31: 1392-1399 (2001-01-01)
Badock V; Steinhusen U; Bommert K; Otto A
Prefractionation of protein samples for proteome analysis using reversed-phase high-performance liquid chromatography
Electrophoresis 22: 2856-2864 (2001-01-01)
Wuchter C; Ratei R; Spahn G; Schoch C; Harbott J; Schnittger S; Haferlach T; Creutzig U; Sperling C; Karawajew L; Ludwig WD
Impact of CD133 (AC133) and CD90 expression analysis for acute leukemia immunophenotyping
Haematologica 86: 154-161 (2001-01-01)
Monga SP; Tang Y; Candotti F; Rashid A; Wildner O; Mishra B; Iqbal S; Mishra L
Expansion of hepatic and hematopoietic stem cells utilizing mouse embryonic liver explants
Cell Transplantation 10: 81-89 (2001-01-01)
Steinhusen U; Weiske J; Badock V; Tauber R; Bommert K; Huber O
Cleavage and shedding of E-cadherin after induction of apoptosis
Journal of Biological Chemistry 276: 4972-4980 (2001-01-01)
Wieder T; Essmann F; Prokop A; Schmelz K; Schulze-Osthoff K; Beyaert R; Doerken B; Daniel PT
Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3
Blood 97: 1378-1387 (2001-03-01)
Wassmuth R; Lentzsch S; Erdbruegger U; Schulz-Menger J; Doerken B; Dietz R; Friedrich MG
Subclinical cardiotoxic effects of anthracyclines as assessed by magnetic resonance imaging - A pilot study
American Heart Journal 141: 1007-1013 (2001-01-01)
Wuchter C; Krappmann D; Cai Z; Ruppert V; Scheidereit C; Doerken B; Ludwig WD; Karawajew L
In vitro susceptibility to TRAIL-induced apoptosis of acute leukemia cells in the context of TRAIL receptor gene expression and constitutive NF-kappaB activity
Leukemia 15: 921-928 (2001-01-01)
Sturm I; Petrowsky H; Volz R; Lorenz M; Radetzki S; Hillebrand T; Wolff G; Hauptmann S; Doerken B; Daniel PT
Analysis of p53/BAX/p16(ink4a/CDKN2) in esophageal squamous cell carcinoma: High BAX and p16(nk4a/CDKN2) identifies patients with good prognosis
Journal of Clinical Oncology 19: 2272-2281 (2001-01-01)
Wieder T; Prokop A; Bagci B; Essmann F; Bernicke D; Schulze-Osthoff K; Doerken B; Schmalz HG; Daniel PT; Henze G
Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts
Leukemia 15 (11): 1735-1742 (2001-11-01)
Reich G; Mapara MY; Reichardt P; Doerken B; Maschmeyer G
Infectious complications after high-dose chemotherapy and autologous stem cell transplantation: comparison between patients with lymphoma or multiple myeloma and patients with solid tumors
Bone Marrow Transplantation 27: 525-529 (2001-03-01)
Hoenemann D; Chatterjee M; Savino R; Bommert K; Burger R; Gramatzki M; Doerken B; Bargou RC
The IL-6 receptor antagonist SANT-7 overcomes bone marrow stromal cell-mediated drug resistance of multiple myeloma cells
International Journal of Cancer 93: 674-680 (2001-01-01)
Raisova M; Hossini AM; Eberle J; Riebeling C; Wieder T; Sturm I; Daniel PT; Orfanos CE; Geilen CC
The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis
Journal of Investigative Dermatology 117: 333-340 (2001-08-01)
Wildner O
Oncolytic viruses as therapeutic agents
Annals of Medicine 33: 291-304 (2001-07-01)
D'Amato RJ; Lentzsch S; Anderson KC; Rogers MS
Mechanism of action of thalidomide and 3-aminothalidomide in multiple myeloma
Seminars in Oncology 28, 6: 597-601 (2001-12-01)
Hermann S; Sturm I; Mrozek A; Klosterhalfen B; Hauptmann S; Doerken B; Daniel PT
Bax expression in benign and malignant thyroid tumours: dysregulation of wild-type p53 is associated with a high bax and p21 expression in thyroid carcinoma
International Journal of Cancer 92: 805-811 (2001-01-01)
Bene MC; Bernier M; Casasnovas RO; Castoldi G; Doekharan D; van der Holt B; Knapp W; Lemez P; Ludwig WD; Matutes E; Orfao A; Schoch C; Sperling C; van't Veer MB
Acute myeloid leukaemia MO: haematological, immunophenotypic and cytogenetic characteristics and their prognostic significance: an analysis in 241 patients
British Journal of Haematology 113: 737-745 (2001-01-01)
2000
Tamm I; Kornblau SM; Segall H; Krajewski S; Welsh K; Kitada S; Scudiero DA; Tudor G; Qui YH; Monks A; Andreeff M; Reed JC
Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias
Clinical Cancer Research 6 (5): 1796-1803 (2000-05-01)
Loeffler A; Kufer P; Lutterbuese R; Zettl F; Daniel PT; Schwenkenbecher JM; Riethmueller G; Doerken B; Bargou RC
A recombinant bispecific single-chain antibody, CD19 X CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes
Blood 95: 2098-2103 (2000-01-01)
Stanulla M; Kasper B; Schrappe M; Viehmann S; Harbott J; Ludwig WD; Welte K
Granulocyte colony-stimulating factor receptor expression and 11q23/MLL genotype in childhood acute lymphoblastic leukemia developing during the first 18 months of life
Leukemia 14: 337-338 (2000-02-01)
Schendel DJ; Frankenberger B; Jantzer P; Cayeux S; Noessner E; Willimsky G; Maget B; Pohla H; Blankenstein T
Expression of B7.1 (CD80) in a renal cell carcinoma line allows expansion of tumor-associated cytotoxic T lymphocytes in the presence of an alloresponse
Gene Therapy 7: 2007-2014 (2000-12-01)
Wildner O; Morris JC
Therapy of peritoneal carcinomatosis from colon cancer with oncolytic adenoviruses
Journal of Gene Medicine 2: 353-360 (2000-09-01)
Mathas S; Rickers A; Bommert K; Doerken B; Mapara MY
Anti-CD20-and B-cell receptor-mediated apoptosis: Evidence for shared intracellular signaling pathways
Cancer Research 60: 7170-7176 (2000-01-01)
Bohlander SK; Muschinsky V; Schrader K; Siebert R; Schlegelberger B; Harder L; Schemmel V; Fonatsch C; Ludwig WD; Hiddemann W; Dreyling MH
Molecular analysis of the CALM/AF10 fusion: identical rearrangements in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma patients
Leukemia 14: 93-99 (2000-01-01)
Lengfelder E; Reichert A; Schoch C; Haase D; Haferlach T; Loeffler H; Staib P; Heyll A; Seifarth W; Saussele S; Fonatsch C; Gassmann W; Ludwig WD; Hochhaus A; Beelen D; Aul C; Sauerland MC; Heinecke A; Hehlmann R; Woermann B; Hiddemann W; Buechner T
Double induction strategy including high dose cytarabine in combination with all-trans retinoic acid: effects in patients with newly diagnosed acute promyelocytic leukemia. German AML Cooperative Group
Leukemia 14: 1362-1370 (2000-08-01)
Prokop A; Wieder T; Sturm I; Essmann F; Seeger K; Wuchter C; Ludwig WD; Henze G; Doerken B; Daniel PT
Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2 ratio and loss of spontaneous caspase-3 processing in vivo
Leukemia 14: 1606-1613 (2000-09-01)
Schrappe M; Reiter A; Zimmermann M; Harbott J; Ludwig WD; Henze G; Gadner H; Odenwald E; Riehm H
Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995. Berlin-Frankfurt-Munster
Leukemia 14 (12): 2205-2222 (2000-12-01)
Karawajew L; Ruppert V; Wuchter C; Koesser A; Schrappe M; Doerken B; Ludwig WD
Inhibition of in vitro spontaneous apoptosis by IL-7 correlates with Bcl-2 up-regulation, cortical/mature immunophenotype, and better early cytoreduction of childhood T-cell acute lymphoblastic leukemia
Blood 96: 297-306 (2000-07-01)
Schrappe M; Reiter A; Ludwig WD; Harbott J; Zimmermann M; Hiddemann W; Niemeyer C; Henze G; Feldges A; Zintl F; Kornhuber B; Ritter J; Welte K; Gadner H; Riehm H
Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL-BFM 90. German-Austrian-Swiss ALL-BFM Study Group
Blood 95 (11): 3310-3322 (2000-06-01)
Steinhusen U; Badock V; Bauer A; Behrens J; Wittmann-Liebold B; Doerken B; Bommert K
Apoptosis-induced cleavage of beta-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential
Journal of Biological Chemistry 275: 16345-16353 (2000-01-01)
Wiese A; Wieder T; Mickeleit M; Reinoehl S; Geilen CC; Seydel U; Reutter W
Structure-dependent effects of glucose-containing analogs of platelet activating factor (PAF) on membrane integrity
Biological Chemistry 381: 135-144 (2000-02-01)
Aicher A; Hayden-Ledbetter M; Brady WA; Pezzutto A; Richter G; Magaletti D; Buckwalter S; Ledbetter JA; Clark EA
Characterization of human inducible costimulator ligand expression and function
Journal of Immunology 164: 4689-4696 (2000-05-01)
Pohla H; Frankenberger B; Stadlbauer B; Oberneder R; Hofstetter A; Willimsky G; Pezzutto A; Doerken B; Blankenstein T; Schendel DJ
Allogeneic vaccination for renal cell carcinoma: development and monitoring
Bone Marrow Transplantation 25 Suppl. 2: S83-S87 (2000-05-01)
Schmitt CA; Rosenthal CT; Lowe SW
Genetic analysis of chemoresistance in primary murine lymphomas
Nature Medicine 6: 1029-1035 (2000-09-01)
Wildner O; Morris JC
The role of the E1B 55 kDa gene product in oncolytic adenoviral vectors expressing herpes simplex virus-tk: Assessment of antitumor efficacy and toxicity
Cancer Research 60: 4167-4174 (2000-08-01)
Westermann J; Kopp J; Koerner I; Richter G; Qin Z; Blankenstein T; Doerken B; Pezzutto A
Bcr/abl+ autologous dendritic cells for vaccination in chronic myeloid leukemia
Bone Marrow Transplantation 25 Suppl. 2: S46-S49 (2000-05-01)
Wuchter C; Harbott J; Schoch C; Schnittger S; Borkhardt A; Karawajew L; Ratei R; Ruppert V; Haferlach T; Creutzig U; Doerken B; Ludwig WD
Detection of acute leukemia cells with mixed lineage leukemia (MLL) gene rearrangements by flow cytometry using monoclonal antibody 7.1
Leukemia 14: 1232-1238 (2000-07-01)
Sturm I; Papadopoulos S; Hillebrand T; Benter T; Luck HJ; Wolff G; Doerken B; Daniel PT
Impaired bax protein expression in breast cancer: mutational analysis of the bax and the p53 gene
International Journal of Cancer 87: 517-521 (2000-08-15)
Wuchter C; Karawajew L; Ruppert V; Schrappe M; Harbott J; Ratei R; Doerken B; Ludwig WD
Constitutive expression levels of CD95 and Bcl-2 as well as CD95 function and spontaneous apoptosis in vitro do not predict the response to induction chemotherapy and relapse rate in childhood acute lymphoblastic leukaemia
British Journal of Haematology 110: 154-160 (2000-07-01)
Wuchter C; Karawajew L; Ruppert V; Schrappe M; Buechner T; Schoch C; Haferlach T; Harbott JN; Ratei R; Doerken B; Ludwig WD
Clinical significance of P-glycoprotein expression and function for response to induction chemotherapy, relapse rate and overall survival in acute leukemia
Haematologica 85: 711-721 (2000-07-01)
Reiter A; Schrappe M; Ludwig WD; Tiemann M; Parwaresch R; Zimmermann M; Schirg E; Henze G; Schellong G; Gadner H; Riehm H
Intensive ALL-type therapy without local radiotherapy provides a 90% event-free survival for children with T-cell lymphoblastic lymphoma: a BFM group report
Blood 95: 416-421 (2000-01-15)
Essmann F; Wieder T; Otto A; Mueller EC; Doerken B; Daniel PT
GDP dissociation inhibitor D4-GDI (Rho-GDI 2), but not the homologous Rho-GDI 1, is cleaved by caspase-3 during drug-induced apoptosis
Biochemical Journal 346 Part 3: 777-783 (2000-03-15)
Raisova M; Bektas M; Wieder T; Daniel P; Eberle J; Orfanos CE; Geilen CC
Resistance to CD95/Fas-induced and ceramide-mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release
FEBS Letters 473: 27-32 (2000-05-04)
Schmitt CA; Wallace-Brodeur RR; Rosenthal CT; McCurrach ME; Lowe SW
DNA damage responses and chemosensitivity in the E mu-myc mouse lymphoma model
Cold Spring Harbor Symposia on Quantitative Biology 65: 499-510 (2000-01-01)
Morris JC; Ramsey WJ; Wildner O; Muslow HA; Aguilar-Cordova E; Blaese RM
A phase I study of intralesional administration of an adenovirus vector expressing the HSV-1 thymidine kinase gene (AdV.RSV-TK) in combination with escalating doses of ganciclovir in patients with cutaneous metastatic malignant melanoma
Human Gene Therapy 11: 487-503 (2000-02-10)
Kordes U; Krappmann D; Heissmeyer V; Ludwig WD; Scheidereit C
Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells
Leukemia 14 (3): 399-402 (2000-03)
1999
Jundt F; Anagnostopoulos I; Bommert K; Emmerich F; Mueller G; Foss HD; Royer HD; Stein H; Doerken B
Hodgkin/Reed-Sternberg cells induce fibroblasts to secrete eotaxin, a potent chemoattractant for T cells and eosinophils
Blood 94: 2065-2071 (1999-09-15)
Wuchter C; Karawajew L; Ruppert V; Buechner T; Schoch C; Hafelach T; Ratei R; Doerken B; Ludwig WD
Clinical significance of CD95, Bcl-2 and Bax expression and CD95 function in adult de novo acute myeloid leukemia in context of P-glycoprotein function, maturation stage, and cytogenetics
Leukemia 13: 1943-1953 (1999-12-01)
Emmerich F; Meiser M; Hummel M; Demel G; Foss HD; Jundt F; Mathas S; Krappmann D; Scheidereit C; Stein H; Doerken B
Overexpression of IkappaBalpha without inhibition of NF-kappaB activity and mutations in the IkappaBalpha gene in Reed-Sternberg cells
Blood 94: 3129-3134 (1999-11-01)
Daniel PT; Scholz C; Essmann F; Westermann J; Pezzutto A; Doerken B
CD95/Fas-triggered apoptosis of activated T lymphocytes is prevented by dendritic cells through a CD58-dependent mechanism
Experimental Hematology 27: 1402-1408 (1999-09-01)
Benter T; Teichgraeber UKM; Kluehs L; Doerken B
Percutaneous central venous catheterization with a lethal complication
Intensive Care Medicine 25: 1180-1182 (1999-10-01)
Aicher A; Shu GL; Magaletti D; Mulvania T; Pezzutto A; Craxton A; Clark EA
Differential role for p38 mitogen-activated protein kinase in regulating CD40-induced gene expression in dendritic cells and B cells
Journal of Immunology 163: 5786-5795 (1999-12-01)
Mueller EC; Schuemann M; Rickers A; Bommert K; Wittmann-Liebold B; Otto A
Study of Burkitt lymphoma cell line proteins by high resolution two-dimensional gel electrophoresis and nanoelectrospray mass spectrometry
Electrophoresis 20: 320-330 (1999-02-01)
Fan W; Richter G; Cereseto A; Beadling C; Smith KA
Cytokine response gene 6 induces p21 and regulates both cell growth and arrest
Oncogene 18: 6573-6582 (1999-11-11)
Bene MC; Bernier M; Castoldi G; Faure GC; Knapp W; Ludwig WD; Matutes E; Orfao A; van't Veer M
Impact of immunophenotyping on management of acute leukemias
Haematologica 84: 1024-1034 (1999-11-01)
Krappmann D; Emmerich F; Kordes U; Scharschmidt E; Doerken B; Scheidereit C
Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells
Oncogene 18: 943-953 (1999-01-28)
Doerdelmann M; Reiter A; Borkhardt A; Ludwig WD; Goetz N; Viehmann S; Gadner H; Riehm H; Schrappe M
Prednisone response is the strongest predictor of treatment outcome in infant acute lymphoblastic leukemia
Blood 94: 1209-1217 (1999-08-15)
Buechner T; Hiddemann W; Woermann B; Loeffler H; Gassmann W; Haferlach T; Fonatsch C; Haase D; Schoch C; Hossfeld D; Lengfelder E; Aul C; Heyll A; Maschmeyer G; Ludwig WD; Sauerland MC; Heinecke A
Double induction strategy for acute myeloid leukemia: the effect of high-dose cytarabine with mitoxantrone instead of standard-dose cytarabine with daunorubicin and 6-thioguanine: a randomized trial by the german AML cooperative group
Blood 93: 4116-4124 (1999-06-15)
Beadling C; Druey KM; Richter G; Kehrl JH; Smith KA
Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes
Journal of Immunology 162: 2677-2682 (1999-03-01)
Rickers A; Peters N; Badock V; Beyaert R; Vandenabeele P; Doerken B; Bommert K
Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis
European Journal of Biochemistry 261: 269-274 (1999-01-01)
Lentzsch S; Reichardt P; Weber F; Budach V; Doerken B
Brain metastases in breast cancer: prognostic factors and management
European Journal of Cancer 35: 580-585 (1999-04-01)
Mapara MY; Koerner IJ; Lentzsch S; Krahl D; Reichardt P; Doerken B
Combined positive/negative purging and transplantation of peripheral blood progenitor cell autografts in breast cancer patients: a pilot study
Experimental Hematology 27: 169-175 (1999-01-01)
Reiter A; Schrappe M; Tiemann M; Ludwig WD; Yakisan E; Zimmermann M; Mann G; Chott A; Ebell W; Klingebiel T; Graf N; Kremens B; Mueller-Weihrich S; Pluess HJ; Zintl F; Henze G; Riehm H
Improved treatment results in childhood B-cell neoplasms with tailored intensification of therapy: a report of the Berlin-Frankfurt-Muenster group trial NHL-BFM 90
Blood 94: 3294-3306 (1999-11-15)
Maschmeyer G
Interventional antimicrobial therapy in febrile neutropenic patients
Diagnostic Microbiology and Infectous Disease 34: 205-212 (1999-07-01)
Cayeux S; Richter G; Becker C; Pezzutto A; Doerken B; Blankenstein T
Direct and indirect T cell priming by dendritic cell vaccines
European Journal of Immunology 29: 225-234 (1999-01-01)
Stroszczynski C; Oellinger J; Hosten N; Spahn G; Amthauer H; Ricke J; Hoffmann KT; Eichstaedt H; Ludwig WD; Felix R
Staging and monitoring of malignant lymphoma of the bone: comparison of 67Ga scintigraphy and MRI
Journal of Nuclear Medicine 40: 387-393 (1999-03-01)
Sturm I; Koehne CH; Wolff G; Petrowsky H; Hillebrand T; Hauptmann S; Lorenz M; Doerken B; Daniel PT
Analysis of the p53/BAX pathway in colorectal cancer: low BAX is a negative prognostic factor in patients with resected liver metastases
Journal of Clinical Oncology 17: 1364-1374 (1999-05-01)
Schwartz S; Behre G; Heinemann V; Wandt H; Schilling E; Arning M; Trittin A; Kern WV; Boenisch O; Bosse D; Lenz K; Ludwig WD; Hiddemann W; Siegert W; Beyer J
Aerosolized amphotericin B inhalations as prophylaxis of invasive aspergillus infections during prolonged neutropenia: results of a prospective randomized multicenter trial
Blood 93: 3654-3661 (1999-06-01)
Daniel PT; Sturm I; Ritschel S; Friedrich K; Doerken B; Bendzko P; Hillebrand T
Detection of genomic DNA fragmentation during apoptosis (DNA ladder) and the simultaneous isolation of RNA from low cell numbers
Analytical Biochemistry 266: 110-115 (1999-01-01)
Langerak AW; Wolvers-Tettero IL; van den Beemd MWM; van Wering ER; Ludwig WD; Haehlen K; Necker A; van Dongen JJM
Immunophenotypic and immunogenotypic characteristics of TCR gammadelta+ T cell acute lymphoblastic leukemia
Leukemia 13: 206-214 (1999-02-01)
Schmitt CA; Schwaeble W; Wittig BM; Meyer Zum Bueschenfelde KH; Dippold WG
Expression and regulation by interferon-gamma of the membrane-bound complement regulators CD46 (MCP), CD55 (DAF) and CD59 in gastrointestinal tumours
European Journal of Cancer 35: 117-124 (1999-01-01)
Cayeux S; Qin Z; Doerken B; Blankenstein T
Vaccines using gene-modified tumor cells
Gene therapy :Principles and Applications : 283-298 (1999-01-01)
Schmitt CA; Lowe SW
Apoptosis and therapy
Journal of Pathology 187: 127-137 (1999-01-01)
Daniel PT; Pun KT; Ritschel S; Sturm I; Holler J; Doerken B; Brown R
Expression of the death gene Bik/Nbk promotes sensitivity to drug-induced apoptosis in corticosteroid-resistant T-cell lymphoma and prevents tumor growth in severe combined immunodeficient mice
Blood 94: 1100-1107 (1999-08-01)
1998
Rickers A; Brockstedt E; Mapara MY; Otto A; Doerken B; Bommert K
Inhibition of CPP32 blocks surface IgM-mediated apoptosis and D4-GDI cleavage in human BL 60 Burkitt lymphoma cells
European Journal of Immunology 28: 296-304 (1998-01-01)
Koehne CH; Thuss-Patience P; Friedrich M; Daniel PT; Kretzschmar A; Benter T; Bauer B; Dietz R; Doerken B
Raltitrexed (Tomudex): an alternative drug for patients with colorectal cancer and 5-fluorouracil associated cardiotoxicity
British Journal of Cancer 77: 973-977 (1998-01-01)
Ellerbrok H; Fleischer C; Salemi M; Reinhardt P; Ludwig WD; Vandamme AM; Pauli G
Sequence analysis of the first HTLV-I infection in Germany without relations to endemic areas-short communication
AIDS Research and Human Retroviruses 14: 1199-1203 (1998-09-01)
Dordelmann M; Schrappe M; Reiter A; Zimmermann M; Graf N; Schott G; Lampert F; Harbott J; Niemeyer C; Ritter J; Dorffel W; Nessler G; Kuhl J; Riehm H
Down's syndrome in childhood acute lymphoblastic leukemia: clinical characteristics and treatment outcome in four consecutive BFM trials.
Leukemia 12: 645-651 (1998-05-01)
Kern W; Aul C; Maschmeyer G; Schoenrock-Nabulsi R; Ludwig WD; Bartholomaeus A; Bettelheim P; Woermann B; Buechner T; Hiddemann W
Superiority of high-dose over intermediate-dose cytosine arabinoside in the treatment of patients with high-risk acute myeloid leukemia: results of an age-adjusted prospective randomized comparison
Leukemia 12: 1049-1055 (1998-07-01)
Wieder T; Orfanos CE; Geilen CC
Induction of ceramide-mediated apoptosis by the anticancer pPhospholipid analog, hexadecylphosphocholine
Journal of Biological Chemistry 273 (18): 11025-11031 (1998-05-01)
Gramatzki M; Ludwig WD; Burger R; Moos P; Rohwer P; Grunert C; Sendler A; Kalden JR; Andreesen R; Henschke F; Moldenhauer G
Antibodies TC-12 ("unique") and TH-111 (CD96) characterize T-cell acute lymphoblastic leukemia and a subgroup of acute myeloid leukemia
Experimental Hematology 26: 1209-1214 (1998-12-01)
Mickeleit M; Wieder T; Arnold M; Geilen CC; Mulzer J; Reutter W
A glucose-containing ether lipid (Glc-PAF) as an antiproliferative analogue of the platelet-activating factor
Angewandte Chemie International Edition 37 (3): 351-353 (1998-02-16)
Brockstedt E; Rickers A; Kostka S; Laubersheimer A; Doerken B; Wittmann-Liebold B; Bommert K; Otto A
Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line - cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3
Journal of Biological Chemistry 273 (43): 28057-28064 (1998-10-23)
Bene MC; Bernier M; Casasnovas RO; Castoldi G; Knapp W; Lanza F; Ludwig WD; Matutes E; Orfao A; Sperling C; van't Veer MB
The reliability and specificity of c-kit for the diagnosis of acute myeloid leukemias and undifferentiated leukemias
Blood 92 (2): 596-599 (1998-07-15)
Daniel PT; Kroidl A; Kopp J; Sturm I; Moldenhauer G; Doerken B; Pezzutto A
Immunotherapy of B-cell lymphoma with CD3x19 bispecific antibodies: costimulation via CD28 prevents "Veto" apoptosis of antibody-targeted cytotoxic T cells
Blood 92 (12): 4750-4757 (1998-12-15)
Daniel PT; Kroidl A; Cayeux S; Scholz C; Sturm I; Blankenstein T; Pezzutto A; Doerken B
Retroviral B7.1 gene transfer in cancer cells protects cytotoxic T cells from deletion by "veto" apoptosis
Advances in Experimental Medicine and Biology 451: 265-276 (1998-01-01)
Panzenboeck B; Bartunek P; Mapara MY; Zenke M
Growth and differentiation of human stem cell factor/erythropoietin-dependent erythroid progenitor cells in vitro
Blood 92 (10): 3658-3668 (1998-11-15)
Koehne CH; Schoeffski P; Wilke H; Kaeufer C; Andreesen R; Ohl U; Klaasen U; Westerhausen M; Hiddemann W; Schott G; Harstick A; Bade J; Horster A; Schubert U; Hecker H; Doerken B; Schmoll HJ
Effective biomodulation by leucovorin of high-dose infusion fluorouracil given as a weekly 24-hour infusion: results of a randomized trial in patients with advanced colorectal cancer
Journal of Clinical Oncology 16 (2): 418-426 (1998-02)
Dreyling MH; Schrader K; Fonatsch C; Schlegelberger B; Haase D; Schoch C; Ludwig WD; Loeffler H; Buechner T; Wormann B; Hiddemann W; Bohlander SK
MLL and CALM are fused to AF10 in morphologically distinct subsets of acute leukemia with translocation t(10;11): both rearrangements are associated with a poor prognosis
Blood 91 (12): 4662-4667 (1998-06-15)
Beltinger C; Kurz E; Boehler T; Schrappe M; Ludwig WD; Debatin KM
CD95 (APO-1/Fas) mutations in childhood T-lineage acute lymphoblastic leukemia
Blood 91 (10): 3943-3951 (1998-05-15)
Streubel B; Sauerland C; Heil G; Freund M; Bartels H; Lengfelder E; Wandt H; Ludwig WD; Nowotny H; Baldus M; Grothaus-Pinke B; Buechner T; Fonatsch C
Correlation of cytogenetic, molecular cytogenetic, and clinical findings in 59 patients with ANLL or MDS and abnormalities of the short arm of chromosome 12
British Journal of Haematology 100: 521-533 (1998-03-01)
Rinaldi N; Barth TF; Weis D; Schwarz-Eywill M; Pezzutto A; Lukoschek M; Brocai D; Brado B
Loss of laminin and of the laminin receptor integrin subunit � in situ correlates with cytokine induced down regulation of alpha 6 on fibroblast-like synoviocytes from rheumatoid arthritis
Annals of the Rheumatic Diseases 57: 559-565 (1998-09-01)
Hildebrandt M; Blaser F; Beyer J; Siegert W; Mapara MY; Huhn D; Salama A
Detection of tumor cells in peripheral blood samples from patients with germ cell tumors using immunocytochemical and reverse transcriptase-polymerase chain reaction techniques
Bone Marrow Transplantation 22: 771-775 (1998-10-01)
Beltinger C; Boehler T; Karawajew L; Ludwig WD; Schrappe M; Debatin KM
Mutation analysis of CD95 (APO-1/Fas) in childhood B-lineage acute lymphoblastic leukaemia
British Journal of Haematology 102: 722-728 (1998-08-01)
Westermann J; Aicher A; Qin Z; Cayeux S; Daemen K; Blankenstein T; Doerken B; Pezzutto A
Retroviral interleukin-7 gene transfer into human dendritic cells enhances T cell activation
Gene Therapy 5: 264-271 (1998-01-01)
Schmitt CA; Thaler KR; Wittig BM; Kaulen H; Meyer Zum Bueschenfelde KH; Dippold WG
Detection of the DCC gene product in normal and malignant colorectal tissues and its relation to a codon 201 mutation
British Journal of Cancer 77: 588-594 (1998-02-01)
Schott G; Sperling C; Schrappe M; Ratei R; Martin M; Meyer U; Riehm H; Ludwig WD
Immunophenotypic and clinical features of T-cell receptor gammadelta+ T-lineage acute lymphoblastic leukaemia
British Journal of Haematology 101: 753-755 (1998-01-01)
Wolff G; Koerner I; Schumacher A; Arnold W; Doerken B; Mapara MY
Ex vivo breast cancer cell purging by adenovirus- mediated cytosine deaminase gene transfer and short-term incubation with 5-Fluorocytosine completely prevents tumor growth after transplantation
Human Gene Therapy 9: 2277-2284 (1998-01-01)
Mueller-Wieprecht V; Riebeling C; Alexander C; Scholz FR; Hoeer A; Wieder T; Orfanos CE; Geilen CC
Expression and regulation of phospholipase D in the human keratinocyte cell line HaCaT
FEBS Letters 425: 199-203 (1998-03-27)
Reichardt P; Tilgner J; Hohenberger P; Doerken B
Dose-intensive chemotherapy with ifosfamide, epirubicin, and filgrastim for adult patients with metastatic or locally advanced soft tissue sarcoma: A phase II study
Journal of Clinical Oncology 16 (4): 1438-1443 (1998-04)
Ritterbach J; Hiddemann W; Beck JD; Schrappe M; Janka-Schaub G; Ludwig WD; Harbott J; Lampert F
Detection of hyperdiploid karyotypes (>50 chromosomes) in childhood acute lymphoblastic leukemia (ALL) using fluorescence in situ hybridization (FISH)
Leukemia 12: 427-433 (1998-03-01)
Scholz C; Patton KT; Anderson DE; Freeman GJ; Hafler DA
Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation
Journal of Immunology 160 (3): 1532-1538 (1998-02-01)
Rieder H; Bonwetsch C; Janssen LAJ; Maurer J; Janssen JWG; Schwartz S; Ludwig WD; Gassmann W; Bartram CR; Thiel E; Loeffler H; Gokbuget N; Hoelzer D; Fonatsch C
High rate of chromosome abnormalities detected by fluorescence in situ hybridization using BCR and ABL probes in adult acute lymphoblastic leukemia
Leukemia 12: 1473-1481 (1998-09-01)
Ludwig WD; Rieder H; Bartram CR; Heinze B; Schwartz S; Gassmann W; Loeffler H; Hossfeld D; Heil G; Handt S; Heyll A; Diedrich H; Fischer K; Weiss A; Voelkers B; Aydemir U; Fonatsch C; Goekbuget N; Thiel E; Hoelzer D
Immunophenotypic and genotypic features, clinical characteristics, and treatment outcome of adult pro-B acute lymphoblastic leukemia: Results of the German multicenter trials GMALL 03/87 and 04/89
Blood 92 (6): 1898-1909 (1998-09-15)
Tomeczkowski J; Frick D; Schwinzer B; Wittner N; Ludwig WD; Reiter A; Welte K; Sykora KW
Expression and regulation of c-kit receptor and response to stem cell factor in childhood malignant T-lymphoblastic cells
Leukemia 12: 1221-1229 (1998-08-01)
Jung D; Jaeger E; Cayeux S; Blankenstein T; Hilmes C; Karbach J; Moebius U; Knuth A; Huber C; Seliger B
Strong immunogenic potential of a B7 retroviral expression vector: Generation of HLA-B7-restricted CTL response against selectable marker genes
Human Gene Therapy 9: 53-62 (1998-01-01)
1997
Gassmann W; Loeffler H; Thiel E; Ludwig WD; Schwartz S; Haferlach T; Maurer J; Rieder H; Fonatsch C; Goekbuget N; Hoelzer D
Morphological and cytochemical findings in 150 cases of T-lineage acute lymphoblastic leukemia in adults
British Journal of Haematology 97: 372-382 (1997-01-01)
Cayeux S; Richter G; Noffz G; Doerken B; Blankenstein T
Influence of gene modified (IL 7, IL 4, and B7) tumor cell vaccines on tumor antigen presentation
Journal of Immunology 158: 2834-2841 (1997-01-01)
Borkhardt A; Cazzaniga G; Viehmann S; Valsecchi MG; Ludwig WD; Burci L; Mangioni S; Schrappe M; Riehm H; Lampert F; Basso G; Masera G; Harbott J; Biondi A
Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the german and italian multicenter therapy trials
Blood 90: 571-577 (1997-01-01)
Mielcarek M; Sperling C; Schrappe M; Meyer U; Riehm H; Ludwig WD
Expression of intercellular adhesion molecule 1 (ICAM-1) in childhood acute lymphoblastic leukemia: correlation with clinical features and outcome.
British Journal of Haematology 96: 301-307 (1997-01-01)
Daniel PT; Kroidl A; Cayeux S; Bargou RC; Blankenstein T; Doerken B
Costimulatory signals through B7.1/CD28 prevent T cell apoptosis during target cell lysis
Journal of Immunology 159 (8): 3808-3815 (1997-10-15)
Conter V; Schrappe M; Arico M; Reiter A; Rizzari C; Doerdelmann M; Valsecchi MG; Zimmermann M; Ludwig WD; Basso G; Masera G; Riehm H
Role of cranial radiotherapy for childhood T-cell acute lymphobalstic leukemia with high WBC count and good response to prednisone
Journal of Clinical Oncology 15 (8): 2786-2791 (1997-08)
Brand K; Arnold W; Bartels T; Lieber A; Kay MA; Strauss M; Doerken B
Liver associated toxicity of the hsv tk/gcv approach and adenoviral vectors
Cancer Gene Therapy 4 (1): 9-16 (1997-01-01)
Bokemeyer C; Nowak P; Haupt A; Metzner B; Koehne H; Hartmann JT; Kanz L; Schmoll HJ
Treatment of brain metastases in patients with testicular cancer
Journal of Clinical Oncology 15 (4): 1449-1454 (1997-04)
Worgall S; Wolff G; Falck-Pedersen E; Crystal RG
Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration
Human Gene Therapy 8: 37-44 (1997-01-01)
Rieder H; Ludwig WD; Gassmann W; Maurer J; Janssen JW; Gokbuget N; Schwartz S; Thiel E; Loeffler H; Bartram CR; Hoelzer D; Fonatsch C
Prognostic significance of additional chromosome abnormalities in adult patients with philadelphia chromosome positive acute lymphoblastic leukaemia
British Journal of Haematology 95: 678-691 (1997-01-01)
Cayeux S; Doerken B; Blankenstein T
Tumor cell vaccines using genetically modified cells coexpressing cytokines and the T cell costimulatory molecule B7
Concepts in Gene Therapy : 487-503 (1997-01-01)
Sperling C; Schwartz S; Buechner T; Thiel E; Ludwig WD
Expression of the stem cell factor receptor c-kit (CD117) in acute leukemias
Haematologica 82: 617-621 (1997-01-01)
Aicher A; Westermann J; Cayeux S; Willimsky G; Daemen K; Blankenstein T; Uckert W; Doerken B; Pezzutto A
Successful retroviral mediated transduction of a receptor gene in human dendritic cells: feasibility of therapy with gene-modified antigen presenting cells
Experimental Hematology 25: 39-44 (1997-01-01)
Wolff G; Worgall S; van Rooijen N; Song WR; Harvey BG; Crystal RG
Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ
Journal of Virology 71 (1): 624-629 (1997-01-01)
Harstrick A; Kohne CH; Hiddemann W; Preusser P; Strumberg D; Berns T; Seeber S; Wilke H; Schmoll HJ
Modulation of 5-fluorouracil with methotrexate and low-dose N-(phosphonacetyl)-L-aspartate (PALA) is inactive in advanced pancreatic carcinoma
Annals of Oncology 8: 917-918 (1997-09-01)
Hildebrandt M; Mapara MY; Koerner IJ; Bargou RC; Moldenhauer G; Doerken B
Reverse transcriptase-polymerase chain reaction (RT-PCR)-controlled immunomagnetic purging of breast cancer cells using the magnetic cell separation (MACS) system: a sensitive method for monitoring purging efficiency
Experimental Hematology 25: 57-65 (1997-01-01)
Worgall S; Leopold PL; Wolff G; Ferris B; Van Roijen N; Crystal RG
Role of alveolar macrophages in rapid elimination of adenovirus vectors administered to the epithelial surface of the respiratory tract
Human Gene Therapy 8 (14): 1675-1684 (1997-09-20)
Haferlach T; Winkemann M; Ramm-Petersen L; Meeder M; Schoch R; Weber-Matthiesen K; Schlegelberger B; Schoch C; Ludwig WD; Hiddemann W; Loffler H
New insights into the biology of Philadelphia-chromosome-positive acute lymphoblastic leukaemia using a combination of May-Grunwald-Giemsa staining and fluorescence in situ hybridization techniques at the single cell level
British Journal of Haematology 99: 452-459 (1997-11-01)
Cayeux S; Richter G; Becker C; Beck C; Aicher A; Pezzutto A; Doerken B; Blankenstein T
Lack of correlation between rejection of tumor cells co-expressing interleukin 2 and B7.1 and vaccine efficiency
European Journal of Immunology 27: 1657-1662 (1997-01-01)
Bargou RC; Juerchott K; Wagener C; Bergmann S; Metzner S; Bommert K; Mapara MY; Winzer KJ; Dietel M; Doerken B; Royer HD
Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression
Nature Medicine 3: 447-450 (1997-01-01)
Karawajew L; Wuchter C; Ruppert V; Drexler H; Gruss HJ; Doerken B; Ludwig WD
Differential CD95 expression and function in T and B lineage acute lymphoblastic leukemia cells
Leukemia 11: 1245-1252 (1997-01-01)
Weinmann P; Bommert K; Mapara MY; Doerken B; Bargou RC
Overexpression of the death-promoting gene bax-alpha sensitizes human BL-41 Burkitt lymphoma cells for surface IgM-mediated apoptosis
European Journal of Immunology 27: 2466-2468 (1997-01-01)
Bargou RC; Emmerich F; Krappmann D; Bommert K; Mapara MY; Arnold W; Royer HD; Grinstein E; Greiner A; Scheidereit C; Doerken B
Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells
Journal of Clinical Investigation 100 (12): 2961-2969 (1997-12-15)
Hoellsberg P; Scholz C; Anderson DE; Greenfield EA; Kuchroo VK; Freeman GJ; Hafler DA
Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4
Journal of Immunology 159 (10): 4799-4805 (1997-11-15)
Daniel PT; Oettinger U; Mapara MY; Bommert K; Bargou RC; Doerken B
Activation and activation induced death of human tonsillar b cells and burkitt lymphoma cells: lack of cd95 (fas/apo 1) ligand expression and function
European Journal of Immunology 27: 1029-1034 (1997-01-01)
Koehne CH; Harstrick A; Hiddemann W; Schoeffski P; Wilke H; Bokemeyer C; Doerken B; Schmoll HJ
Modulation of 5-fluorouracil with methotrexate and low-dose N- (phosphonacetyl)-L-aspartate in patients with advanced colorectal cancer. results of a phase II study
European Journal of Cancer 33: 1896-1899 (1997-01-01)
Mapara MY; Koerner IJ; Hildebrandt M; Bargou RC; Krahl D; Reichardt P; Doerken B
Monitoring of tumor cell purging after highly efficient immunomagnetic selection of CD34 cells from leukapheresis products in breast cancer patients: comparision of immunocytochemical tumor cells staining and RT-PCR
Blood 89 (1): 337-344 (1997-01-01)
1996
Creutzig U; Ritter J; Vormoor J; Ludwig WD; Niemeyer C; Reinisch I; Stollmann-Gibbels B; Zimmermann M; Harbott J
Myelodysplasia and acute myelogenous leukemia in Down's syndrome. A report of 40 children of the AML-BFM Study Group
Leukemia 10 (11): 1677-1686 (1996-11-01)
Cayeux S; Beck C; Doerken B; Blankenstein T
Coexpression of interleukin-4 and B7.1 in murine tumor cells leads to improved tumor rejection and vaccine effect compared to single gene transfectants and a classical adjuvant
Human Gene Therapy 7 (4): 525-529 (1996-01-01)
Lubbe AS; Bergemann C; Riess H; Schriever F; Reichardt P; Possinger K; Matthias M; Doerken B; Herrmann F; Gurtler R; Hohenberger P; Haas N; Sohr R; Sander B; Lemke AJ; Ohlendorf D; Huhnt W; Huhn D
Clinical experiences with magnetic drug targeting: a phase I study with 4'-epidoxorubicin in 14 patients with advanced solid tumors
Cancer Research 56: 4686-4693 (1996-10-15)
Beyermann B; Agthe AG; Adams HP; Seeger K; Linderkamp C; Goetze G; Ludwig WD; Henze G
Clinical features and outcome of children with first marrow relapse of acute lymphoblastic leukemia expressing BCR-ABL fusion transcripts
Blood 87 (4): 1532-1538 (1996-02-15)
Scholz C; Freeman GJ; Greenfield EA; Hafler DA; Hollsberg P
Activation of human T cell lymphotropic virus type I-infected T cells is independent of B7 costimulation
Journal of Immunology 157 (7): 2932-2938 (1996-10-01)
Hoelzer D; Ludwig WD; Thiel E; Gassmann W; Loeffler H; Fonatsch C; Rieder H; Heil G; Heinze B; Arnold R; Hossfeld D; Buechner T; Koch P; Freund M; Hiddemann W; Maschmeyer G; Heyll A; Aul C; Faak T; Kuse R; Ittel TH; Gramatzki M; Diedrich H; Kolbe K; Fuhr HG; Fischer K; Schadeck-Gressel C; Weiss A; Strohscheer I; Metzner B; Fabry U; Gokbuget N; Volkers B; Messerer D; Ueberla K
Improved outcome in adult b cell acute lymphoblastic leukemia
Blood 87 (2): 495-508 (1996-01-01)
Zhao YM; Poetsch M; Weber-Matthiesen K; Rohde G; Winkemann M; Haferlach T; Gassmann W; Ludwig WD; Grote W; Loeffler H; Schlegelberger B
Secondary acute leukaemias with 11q23 rearrangement: clinical, cytogenetic, fish and fiction studies
British Journal of Haematology 92 (3): 673-680 (1996-01-01)
Dehmel U; Zaborski M; Meierhoff G; Rosnet O; Birnbaum D; Ludwig WD; Quentmeier H; Drexler HG
Effects of FLT3 ligand on human leukemia cells. I. proliferative response of myeloid leukemia cells
Leukemia 10 (2): 261-270 (1996-01-01)
Schumann RR; Pfeil D; Lamping N; Kirschning C; Scherzinger G; Schlag PM; Karawajew L; Herrmann F
Lipopolysaccharide induces the rapid tyrosine phosphorylation of the mitogen-activated protein kinases erk-1 and p38 in cultured human vascular endothelial cells requiring the presence of soluble CD14
Blood 87 (7): 2805-2814 (1996-04-01)
Schmidt CA; Przybylski G; Tietze A; Oettle H; Siegert W; Ludwig WD
Acute myeloid and T-cell acute lymphoblastic leukaemia with aberrant antigen expression exhibit similar TCRdelta gene rearrangements
British Journal of Haematology 92 (4): 929-936 (1996-01-01)
Weber-Nordt RM; Egen C; Wehinger J; Ludwig WD; Gouilleuxgruart V; Mertelsmann R; Finke J
Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in epstein-barr virus (EBV)-related lymphoma cell lines
Blood 88 (3): 809-816 (1996-08-01)
Davies DB; Karawajew L; Veselkov AN
1H-NMR structural analysis of ethidium bromide complexation with self-complementary deoxytetranucleotides 5'-d(ApCpGpT), 5'-d(ApGpCpT), and 5'-d(TpGpCpA) in aqueous solution.
Biopolymers 38 (6): 745-757 (1996-01-01)
Bargou RC; Leng C; Krappmann D; Emmerich F; Mapara MY; Bommert K; Royer HD; Scheidereit C; Doerken B
High level nuclear NF-kB and Oct-2 is a common feature of cultured Hodgkin/Sternberg cells
Blood 87 (10): 4340-4347 (1996-01-01)
Wagener C; Bargou RC; Daniel PT; Bommert K; Mapara MY; Royer HD; Doerken B
Induction of the death-promoting gene bax-alpha sensitizes cultured breast-cancer cells to drug-induced apoptosis
International Journal of Cancer 67 (1): 138-141 (1996-07-03)
Scholz C; Hafler DA; Hoellsberg P
Downegulation of IL-10 secretion and enhanced antigen presenting abilities following HTLV-I infection of T-cells
Journal of Neuroscience Research 45: 786-794 (1996-01-01)
Quentmeier H; Zaborski M; Graf G; Ludwig WD; Drexler HG
Expression of the receptor MPL and proliferative effects of its ligand thrombopoietin on human leukemia cells
Leukemia 10: 297-310 (1996-01-01)
Blankenstein T; Cayeux S; Qin Z
Genetic approaches to cancer immunotherapy
Reviews of Physiology Biochemistry and Pharmacology 129: 1-49 (1996-01-01)
Mastrangeli A; Harvey BG; Yao J; Wolff G; Kovesdi I; Crystal RG; Falck Pedersen E
"Sero-switch" adenovirus-mediated in vivo gene transfer: circumvention of anti-adenovirus humoral immune defenses against repeat adenovirus vector administration by changing the adenovirus serotype
Human Gene Therapy 7 (1): 79-87 (1996-01)
Bargou RC; Wagener C; Bommert K; Mapara MY; Daniel PT; Arnold W; Dietel M; Guski H; Feller A; Royer HD; Doerken B
Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice
Journal of Clinical Investigation 97 (11): 2651-2659 (1996-06-01)
1995
Beck C; Cayeux S; Lupton S; Doerken B; Blankenstein T
The thymidine kinase/ganciclovir-mediated "suicide" effect is highly variable in different tumor cells
Human Gene Therapy 6 (12): 1525-1530 (1995-01-01)
Cayeux S; Beck C; Aicher A; Doerken B; Blankenstein T
Tumor cells cotransfected with interleukin-7 and B7.1 genes induce CD25 and CD28 on tumor-infiltrating T lymphocytes and are strong vaccines
European Journal of Immunology 25 (8): 2325-2331 (1995-01-01)
Lagresle C; Bella C; Daniel PT; Krammer PH; Defrance T
Regulation of germinal center B cell differentiation. Role of the human APO-1/Fas (CD95) molecule
Journal of Immunology 154 (11): 5746-5756 (1995-06-01)
Koehne CH; Hiddemann W; Schueller J; Weiss J; Lohrmann HP; Schmitz-Huebner U; Bodenstein H; Schoeber C; Wilke H; Grem J; Schmoll HJ
Failure of orally administered dipyridamole to enhance the antineoplastic activity of fluorouracil in combination with leucovorin in patients with advanced colorectal cancer: a prospective randomized trial
Journal of Clinical Oncology 13: 1201-1208 (1995-01-01)
Mapara MY; Weinmann P; Bommert K; Daniel PT; Bargou RC; Doerken B
Involvement of NAK-1, the human nur77 homologue, in surface IgM-mediated apoptosis in Burkitt lymphoma cell line BL41
European Journal of Immunology 25 (9): 2506-2510 (1995-09)
Koehne CH; Wilke H; Hecker H; Schoeffski P; Kaeufer C; Rauschecker H; Andreesen R; Ohl U; Lange HJ; Klaassen U; Westerhausen M; Hiddemann W; Hennemann B; Schott G; Bade J; Strohmeyer G; Harstrick A; Schubert U; Bokemeyer C; Schmoll HJ
Interferon-alpha does not improve the antineoplastic efficacy of highdose infusional 5-fluorouracil plus folinic acid in advanced colorectal cancer: First results of a randomized multicenter study by the Association of Medical Oncology of the German Cancer Society (AIO)
Annals of Oncology 6: 461-466 (1995-01-01)
Bargou RC; Bommert K; Weinmann P; Daniel PT; Wagener C; Mapara MY; Doerken B
Induction ofBax-alphaprecedes apoptosis in a human B lymphoma cell line: potential role of the bcl-2 gene family in surface lgM-mediated apoptosis
European Journal of Immunology 25: 770-775 (1995-01-01)
Blase L; Daniel PT; Koretz K; Schwartz-Albiez R; Moeller P
The capacity of human malignant B-lymphocytes to disseminate in SCID-mice is correlated with functional expression of the fibronectin receptor alpha5beta1 (CD49e/CD29)
International Journal of Cancer 60: 860-866 (1995-01-01)
Chlichlia K; Moldenhauer G; Daniel PT; Busslinger M; Gazzalo L; Schirrmacher V; Khazaie K
Immediate effects of reversible HTLV-I tax function: T-cell activation and apoptosis
Oncogene 10 (2): 269-277 (1995-01-19)
Creutzig U; Harbott J; Sperling C; Ritter J; Zimmermann M; Loeffler H; Riehm H; Schellong G; Ludwig WD
Clinical significance of surface antigen expression in children with acute myeloid leukemia: results of study AML-BFM-87
Blood 86 (8): 3097-3108 (1995-10-01)
Takeuchi S; Bartram CR; Seriu T; Miller CW; Tobler A; Janssen JW; Reiter A; Ludwig WD; Zimmermann M; Schwaller J; Lee E; Miyoshi I; Koeffler HP
Analysis of a family of cyclin-dependent kinase inhibitors: p15/mts2/ink4b, p16/mts1/ink4a, and p18 genes in acute lymphoblastic leukemia of childhood
Blood 86 (2): 755-760 (1995-01-01)
Mapara MY; Bommert K; Bargou RC; Leng C; Beck C; Ludwig WD; Gierschik P; Doerken B
G protein subunit G alpha16 expression is restricted to progenitor B-cells during human B-cell differentiation
Blood 85 (7): 1836-1842 (1995-04-01)
Janssen JW; Ridge SA; Papadopoulos P; Cotter F; Ludwig WD; Fonatsch C; Rieder H; Ostertag W; Bartram CR; Wiedemann LM
The fusion of TEL and ABL in human acute lymphoblastic leukaemia is a rare event
British Journal of Haematology 90 (1): 222-224 (1995-01-01)
Buehring HJ; Sures I; Jallal B; Weiss FU; Busch FW; Ludwig WD; Handgretinger R; Waller HD; Ullrich A
The receptor tyrosine kinase p185HER2 is expressed on a subset of B-lymphoid blasts from patients with acute lymphoblastic leukemia and chronic myelogenous leukemia
Blood 86 (5): 1916-1923 (1995-09-01)
Reiter A; Schrappe M; Parwaresch R; Henze G; Mueller-Weihrich S; Sauter S; Sykora KW; Ludwig WD; Gadner H; Riehm H
Non-Hodgkin's lymphomas of childhood and adolescence: results of a treatment stratified for biologic subtypes and stage--a report of the Berlin-Frankfurt-Muenster Group
Journal of Clinical Oncology 13: 359-372 (1995-01-01)
Meckenstock G; Heyll A; Schneider EM; Hildebrandt B; Runde V; Aul C; Bartram CR; Ludwig WD; Schneider W
Acute leukemia coexpressing myeloid, B- and T-lineage associated markers: multiparameter analysis of criteria defining lineage commitment and maturational stage in a case of undifferentiated leukemia
Leukemia 9: 260-264 (1995-01-01)
Finn OJ; Jerome KR; Henderson RA; Pecher G; Domenech N; Magarian-Blander J; Barratt-Boyes SM
Muc-1 epithelial tumor mucin-based immunity and cancer vaccines [review]
Immunological Reviews 145: 61-89 (1995-01-01)
Bargou RC; Daniel PT; Mapara MY; Bommert K; Wagener C; Kallinich B; Royer HD; Doerken B
Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax-alpha expresssion in tumor cells correlates with resistance to apoptosis
International Journal of Cancer 60: 854-859 (1995-01-01)
Rieder H; Schnittger S; Bodenstein H; Schwonzen M; Woermann B; Berkovic D; Ludwig WD; Hoelzer D; Fonatsch C
dic(9;20): a new recurrent chromosome abnormality in adult acute lymphoblastic leukemia
Genes Chromosomes & Cancer 13: 54-61 (1995-01-01)
1994
Mapara MY; Bargou RC; Beck C; Heilig B; Doerken B; Moldenhauer G
Lmphotoxin-alpha/beta heterodimer is expressed on leukemic hairy cells and activated human B lymphocytes
International Journal of Cancer 58: 248-253 (1994-01-01)
Przybylski G; Oettle H; Ludwig WD; Siegert W; Schmidt CA
Molecular characterization of illegitimate TCRdelta gene rearrangements in acute myeloid leukaemia
British Journal of Haematology 87: 301-307 (1994-01-01)
Reiter A; Schrappe M; Ludwig WD; Hiddemann W; Sauter S; Henze G; Zimmermann M; Lampert F; Havers W; Niethammer D; Odenwald E; Ritter J; Mann G; Welte K; Gadner H; Riehm H
Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86
Blood 84 (9): 3122-3133 (1994-11-01)
Dhein J; Behrmann I; Daniel PT; Debatin KM; Klas C; Moller P; Oehm A; Trauth BC; Walczak H; Krammer PH
APO-1-mediated apoptosis in normal and malignant lymphocytes
Biochemical Society Transactions 22: 598-600 (1994-01-01)
Maschmeyer G; Link H; Hiddemann W; Meyer P; Helmerking M; Eisenmann E; Schmitt J; Adam D
Pulmonary infiltrations in febrile patients with neutropenia. Risk factors and outcome under empirical antimicrobial therapy in a randomized multicenter study
Cancer 73 (9): 2296-2304 (1994-05-01)
Karawajew L; Jung G; Wolf H; Micheel B; Ganzel K
A flow cytometric long-term cytotoxicity assay
Journal of Immunological Methods 177: 119-130 (1994-01-01)
Karawajew L; Micheel B; Jung GR; Wolf H; Behrsing O
A simple and sensitive method to study effects mediated by soluble lymphokines as demonstrated by the interaction of CD4+ and CD8+ cell subsets during T cell activation
Journal of Immunological Methods 173: 27-31 (1994-01-01)
Coney LR; Daniel PT; Sanborn D; Dhein J; Debatin KM; Krammer PH; Zurawski VR
Apoptotic cell death induced by a mouse-human anti-APO-1 chimeric antibody leads to tumor regression
International Journal of Cancer 58: 562-567 (1994-01-01)
Krammer PH; Behrmann I; Daniel PT; Dhein J; Debatin KM
Regulation of Apoptosis in the Immune System
Current Opinion in Immunology 6 (2): 279-289 (1994-04-01)
Augustine GJ; Betz H; Bommert K; Charlton MP; DeBello WM; Hans M; Swandulla D
Molecular pathway for presynaptic calcium signaling
Advances in Second Messenger and Phosphoprotein Research 29: 139-154 (1994-01-01)
Kotera Y; Fontenot JD; Pecher G; Metzgar RS; Finn OJ
Humoral immunity against a tandem repeat epitope of human mucin MUC-1 in sera from breast, pancreatic, and colon cancer patients
Cancer Research 54 (11): 2856-2860 (1994-06-01)
Daniel PT; Krammer PH
Activation induces sensitivity toward APO-1 (CD95)- mediated apoptosis in human B cells
Journal of Immunology 152: 5624-5632 (1994-01-01)
Janssen JW; Ludwig WD; Borkhardt A; Spadinger U; Rieder H; Fonatsch C; Hossfeld DK; Harbott J; Schulz AS; Repp R; Sykora KW; Hoelzer D; Bartram CR
Pre-pre-B acute lymphoblastic leukemia: high frequency of alternatively spliced ALL1-AF4 transcripts and absence of minimal residual disease during complete remission
Blood 84 (11): 3835-3842 (1994-12-01)
Krammer PH; Dhein J; Walczak H; Behrmann I; Mariani S; Matiba B; Fath M; Daniel PT; Knipping E; Westendorp MO; Debatin KM
The role of APO-1-mediated apoptosis in the immune system
Immunological Reviews 142: 175-191 (1994-12-01)
1993
Notter M; Ludwig WD; Bremer S; Thiel E
Selective targeting of human lymphokine-activated killer cells by CD3 monoclonal antibody against the interferon-inducible high-affinity Fcgamma RI receptor (CD64) on autologous acute myeloid leukemic blast cells
Blood 82 (10): 3113-3124 (1993-11-15)
Mapara MY; Bargou RC; Zugck C ; Doehner H; Ustaoglu F; Jonker RR; Krammer PH; Doerken B
APO-1 mediated apoptosis or proliferation in human chronic B lymphocytic leukemia: correlation with bcl-2 oncogene expression
European Journal of Immunology 23 (3): 702-708 (1993-03)
Jantscheff P; Winkler L; Karawajew L; Kaiser G; Boettger M; Micheel B
Hybrid hybridomas producing bispecific antibodies to CEA and peroxidase isolated by a combination of HAT medium selection and fluorescence activated cell sorting
Journal of Immunological Methods 163: 91-97 (1993-01-01)
Haas R; Gericke G; Witt B; Cayeux S; Hunstein W
Increased serum levels of granulocyte colony-stimulating factor after autologous bone marrow or blood stem cell transplantation
Experimental Hematology 21 (1): 109-113 (1993-01-01)
Sperling C; Buechner T; Sauerland C; Fonatsch C; Thiel E; Ludwig WD
CD34 expression in de novo acute myeloid leukaemia
British Journal of Haematology 85: 635-637 (1993-01-01)
Bommert K; Charlton MP; DeBello WM; Chin GJ; Betz H; Augustine GJ
Inhibition of neurotransmitter release by C2-domain peptides implicates synaptotagmin in exocytosis
Nature 363 (6425): 163-165 (1993-05-13)
Cayeux S; Beverley PC; Schulz R; Doerken B
Elevated plasma prostaglandin E2 levels found in 14 patients undergoing autologous bone marrow or stem cell transplantation
Bone Marrow Transplantation 12: 603-608 (1993-01-01)
Wada M; Bartram CR; Nakamura H; Hachiya M; Chen DL; Borenstein J; Miller CW; Ludwig L; Hansen-Hagge TE; Ludwig WD; Reiter A; Mizoguchi H; Hoeffler HP
Analysis of p53 mutations in a large series of lymphoid hematologic malignancies of childhood
Blood 82 (10): 3163-3169 (1993-11-15)
Cayeux S; Beverley PC; Schultz R; Doerken B
Elevated post-stimulatory intracellular adenosine 3,5-cyclic monophosphate (cAMP) levels are found in peripheral blood cells after ABMT
Bone Marrow Transplantation 11: 483-488 (1993-01-01)
Bohlen H; Manzke O; Patel B; Moldenhauer G; Doerken B; von Fliedner V; Diehl V; Tesch H
Cytolysis of leukemic B-cells by T-cells activated via 2 bispecific antibodies
Cancer Research 53 (18): 4310-4314 (1993-09-15)
1992
Hoelzer D; Thiel E; Ludwig WD; Loeffler H; Buechner T; Freund M; Heil G; Hiddemann W; Maschmeyer G; Volkers B; et al.
The German multicentre trials for treatment of acute lymphoblastic leukemia in adults. The German Adult ALL Study Group
Leukemia 6 (Suppl. 2): 175-177 (1992)
Buechner T; Hiddemann W; Woermann B; Loeffler H; Maschmeyer G; Hossfeld D; Ludwig WD; Nowrousian M; Aul C; Schaefer UW
Longterm effects of prolonged maintenance and of very early intensification chemotherapy in AML: data from AMLCG
Leukemia 6 Suppl 2: 68-71 (1992-01-01)
Freund M; Diedrich H; Ganser A; Gramatzki M; Heil G; Heyll A; Henke M; Hiddemann W; Haas R; Kuse R; Koch P; Link H; Maschmeyer G; Planker M; Queisser W; Schadeck-Gressel C; Schmitz N; von Verschuer U; Wilhelm S; Thiel E; Hoelzer D
Treatment of relapsed or refractory adult acute lymphocytic leukemia
Cancer 69: 709-716 (1992-01-01)
Buechner T; Hiddemann W; Schaefer UW; Loeffler H; Maschmeyer G; Ludwig WD; Aul C; Lathan B; Heinecke A
Combined effect of very early intensification and prolonged post- remission chemotherapy in patients with AML
Leukemia 6 Suppl. 4: 68-70 (1992-01-01)
Straka C; Kroner C; Doerken B; Kvalheim G
Polymerase chain reaction monitoring shows a high efficacy of clinical immunomagnetic purging in patients with centroblastic- centrocytic non-Hodgkin's lymphoma
Blood 80 (10): 2688-2690 (1992-11-15)
Donnelly JP; Maschmeyer G; Daenen S
Selective oral antimicrobial prophylaxis for the prevention of infection in acute leukaemia-ciprofloxacin versus co-trimoxazole plus colistin
European Journal of Cancer 28A: 873-878 (1992-01-01)