Publications
2012
Hanna J; Schuetz A; Zimmermann F; Behlke J; Sommer T; Heinemann U
Structural and biochemical basis of lectin Yos9 dimerization and possible contribution to self-association of the HMG-CoA reductase degradation (HRD) ubiquitin-ligase complex
Journal of Biological Chemistry : (2012-01-18)
2011
Jaenicke LA; Brendebach H; Selbach M; Hirsch C
Yos9p assists in the degradation of certain non-glycosylated proteins from the endoplasmic reticulum
Molecular Biology of the Cell 22 (16): 2937-2945 (2011-08)
Bagola K; Mehnert M; Jarosch E; Sommer T
Protein dislocation from the ER
Biochimica et Biophysica Acta - Biomembranes 1808 (3): 925-936 (2011-03)
2010
Mehnert M; Sommer T; Jarosch E
ERAD ubiquitin ligases: multifunctional tools for protein quality control and waste disposal in the endoplasmic reticulum
BioEssays 32 (10): 905-913 (2010-10)
Buchberger A; Bukau B; Sommer T
Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms
Molecular Cell 40 (2): 238-252 (2010-10-22)
2009
Prestele M; Vogel F; Reichert AS; Herrmann JM; Ott M
Mrpl36 is important for generation of assembly competent proteins during mitochondrial translation
Molecular Biology of the Cell 20 (10): 2615-2625 (2009-05)
Zick M; Duvezin-Caubet S; Schaefer A; Vogel F; Neupert W; Reichert AS
Distinct roles of the two isoforms of the dynamin-like GTPase Mgm1 in mitochondrial fusion
FEBS Letters 583 (13): 2237-2243 (2009-07-07)
Horn SC; Hanna J; Hirsch C; Volkwein C; Schuetz A; Heinemann U; Sommer T; Jarosch E
Usa1 functions as a scaffold of the HRD-ubiquitin ligase
Molecular Cell 36 (5): 782-793 (2009-12-11)
Rabl R; Soubannier V; Scholz R; Vogel F; Mendl N; Vasiljev-Neumeyer A; Koerner C; Jagasia R; Keil T; Baumeister W; Cyrklaff M; Neupert W; Reichert AS
Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g
Journal of Cell Biology 185 (6): 1047-1063 (2009-06-15)
Lutz AK; Exner N; Fett ME; Schlehe JS; Kloos K; Laemmermann K; Brunner B; Kurz-Drexler A; Vogel F; Reichert AS; Bouman L; Vogt-Weisenhorn D; Wurst W; Tatzelt J; Haass C; Winklhofer KF
Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation
Journal of Biological Chemistry 284 (34): 22938-22951 (2009-08-21)
Hirsch C; Gauss R; Horn SC; Neuber O; Sommer T
The ubiquitylation machinery of the endoplasmic reticulum
Nature 458 (7237): 453-460 (2009-03-26)
Clerc S; Hirsch C; Oggier DM; Deprez P; Jakob C; Sommer T; Aebi M
Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulum
Journal of Cell Biology 184 (1): 159-172 (2009-01-05)
2008
Sommer T; Gauss R
Lectins in the endoplasmic reticulum: the sweet side of protein quality control
Developmental Cell 14 (4): 463-464 (2008)
Neuber A; Franke J; Wittstruck A; Schlenstedt G; Sommer T; Stade K
The nuclear export receptor Xpo1/Crm1 is physically and functionally linked to the spindle pole body in budding yeast
Molecular and Cellular Biology 28 (17): 5348-5358 (2008-09)
Bagola K; Sommer T
Protein quality control: On IPODs and other JUNQ
Current Biology 18 (21): R1019-R1021 (2008-11-11)
2007
Mirski SEL; Sparks KE; Friedrich B; Koehler M; Mo YY; Beck WT; Cole SPC
Topoisomerase II binds importin alpha isoforms and exportin/CRM1 but does not shuttle between the nucleus and cytoplasm in proliferating cells
Experimental Cell Research 313: 627-637 (2007-02-01)
2006
Hirsch C; Gauss R; Sommer T
Coping with stress: cellular relaxation techniques
Trends in Cell Biology 16 (12): 657-663 (2006-12)
Vogel F; Bornhoevd C; Neupert W; Reichert AS
Dynamic subcompartmentalization of the mitochondrial inner membrane
Journal of Cell Biology 175 (2): 237-247 (2006-10-23)
Pannek A; Stade K
Nuclear import and export
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2 : 1320-1324 (2006-07-05)
Gauss R; Jarosch E; Sommer T; Hirsch C
A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery
Nature Cell Biology 8 (8): 849-854 (2006-08)
Friedrich B; Quensel C; Sommer T; Hartmann E; Koehler M
NLS and protein context both mediate importin alpha specificity of nuclear import substrates
Molecular and Cellular Biology 26 (23): 8697-8709 (2006-12)
Bornhoevd C; Vogel F; Neupert W; Reichert AS
Mitochondrial membrane potential is dependent on the oligomeric state of F1F0-ATP synthase supracomplexes
Journal of Biological Chemistry 281: 13990-13998 (2006-05-19)
Gauss R; Sommer T; Jarosch E
The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment
EMBO Journal 25 (9): 1827-1835 (2006-05-03)
Sommer T; Dittmar G
Ubiquitination
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2 : 1964-1968 (2006-07-05)
Gauss R; Neuber O; Sommer T
Proteosomal degradation of misfolded proteins
Chaperones : 185-220 (2006-01-01)
2005
Meusser B; Hirsch C; Jarosch E; Sommer T
ERAD: the long road to destruction
Nature Cell Biology 7 (8): 766-772 (2005-08)
Turnbull AP; Kuemmel D; Prinz B; Holz C; Schultchen J; Lang C; Niesen FH; Hofmann KP; Delbrueck H; Behlke J; Mueller EC; Jarosch E; Sommer T; Heinemann U
Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization
EMBO Journal 24: 875-884 (2005-01-01)
Sommer T; Hirsch C
San1p, checking up on nuclear proteins
Cell 120: 734-736 (2005-01-01)
Fagerlund R; Kinnunen L; Koehler M; Julkunen I; Melen K
NF-kappaB is transported into the nucleus by importin alpha3 and importin alpha4
Journal of Biological Chemistry 280: 15942-15951 (2005-01-01)
Dimmer KS; Jakobs S; Vogel F; Altmann K; Westermann B
Mdm31 and Mdm32 are inner membrane proteins required for maintenance of mitochondrial shape and stability of mitochondrial DNA nucleoids in yeast
Journal of Cell Biology 168 (1): 103-115 (2005-01-03)
Neuber O; Jarosch E; Volkwein C; Walter J; Sommer T
Ubx2 links the Cdc48 complex to ER-associated protein degradation
Nature Cell Biology 7: 993-998 (2005-09-18)
Gauss R; Trautwein M; Sommer T; Spang A
New modules for the repeated internal and N-terminal epitope tagging of genes in Saccharomyces cerevisiae
Yeast 22: 1-12 (2005-01-01)
Sommer T; Jarosch E
Pardon me - No access without ubiquitin
Developmental Cell 8: 4-5 (2005-01-01)
2004
Baumeister W; Bachmair A; Chau V; Cohen R; Coffino P; DeMartino G; Deshaies R; Dohmen J; Emr S; Finley D; Hampton R; Hill C; Hochstrasser M; Huber R; Jackson P; Jentsch S; Johnson E; Kwon YT; Pagano M; Pickart C; Rechsteiner M; Scheffner M; Sommer T; Tansey W; Tyers M; Vierstra R; Weissman A; Wilkinson KD; Wolf D
Varshavsky's contributions
Science 306: 1290-1292 (2004-01-01)
Wolf DH; Sommer T; Hilt W
Death gives birth to life: the essential role of the ubiquitin-proteasome system in biology
Biochimica et Biophysica Acta - Molecular Cell Research 1695: 1-2 (2004-01-01)
Hirsch C; Jarosch E; Sommer T; Wolf DH
Endoplasmic reticulum-associated protein degradation - one model fits all?
Biochimica et Biophysica Acta - Molecular Cell Research 1695: 215-223 (2004-01-01)
Meusser B; Sommer T
Vpu-mediated degradation of CD4 reconstituted in yeast reveals mechanistic differences to cellular ER-associated protein degradation
Molecular Cell 14: 247-258 (2004-01-01)
Quensel C; Friedrich B; Sommer T; Hartmann E; Koehler M
In vivo analysis of importin alpha proteins reveals cellular proliferation inhibition and substrate specificity
Molecular and Cellular Biology 24: 10246-10255 (2004-01-01)
2003
Herlan M; Vogel F; Boernhovd C; Neupert W; Reichert AS
Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA
Journal of Biological Chemistry 278: 27781-27788 (2003-01-01)
Messerschmitt M; Jakobs S; Vogel F; Fritz S; Dimmer KS; Neupert W; Westermann B
The inner membrane protein Mdm33 controls mitochondrial morphology in yeast
Journal of Cell Biology 160 (4): 553-564 (2003-02-18)
Jarosch E; Lenk U; Sommer T
Endoplasmic reticulum-associated protein degradation
International Review of Cytology 223: 39-81 (2003-01-01)
2002
Jarosch E; Taxis C; Volkwein C; Bordallo J; Finley D; Wolf DH; Sommer T
Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48
Nature Cell Biology 4 (2): 134-139 (2002-02-01)
Bureik M; Schiffler B; Hiraoka Y; Vogel F; Bernhardt R
Functional expression of human mitochondrial CYP11B2 in fission yeast and identification of a new internal electron transfer protein, etp1
Biochemistry 41: 2311-2321 (2002-01-01)
Lenk U; Yu H; Walter J; Gelman MS; Hartmann E; Kopito RR; Sommer T
A role for mammalian Ubc6 homologues in ER-associated protein degradation
Journal of Cell Science 115: 3007-3014 (2002-01-01)
Taxis C; Vogel F; Wolf DH
ER-Golgi traffic is a prerequisite for efficient ER degradation
Molecular Biology of the Cell 13 (6): 1806-1818 (2002-06)
Jarosch E; Geiss-Friedlander R; Meusser B; Walter J; Sommer T
Protein dislocation from the endoplasmic reticulum - Pulling out the suspect
Traffic 3: 530-536 (2002-01-01)
Stade K; Vogel F; Schwienhorst I; Meusser B; Volkwein C; Nentwig B; Dohmen RJ; Sommer T
A lack of SUMO conjugation affects cNLS-dependent nuclear protein import in yeast
Journal of Biological Chemistry 277: 49554-49561 (2002-01-01)
Sommer T; Jarosch E
BiP binding keeps ATF6 at bay
Developmental Cell 3: 1-2 (2002-01-01)
Zimmer T; Biskup C; Dugarmaa S; Vogel F; Steinbis M; Boehle T; Wu YS; Dumaine R; Benndorf K
Functional expression of GFP-linked human heart sodium channel (hH1) and subcellular localization of the alpha subunit in HEK293 cells and dog cardiac myocytes
Journal of Membrane Biology 186: 1-12 (2002-01-01)
Fujita Y; Krause G; Scheffner M; Zechner D; Leddy HEM; Behrens J; Sommer T; Birchmeier W
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex
Nature Cell Biology 4 (3): 222-231 (2002-03-01)
2001
Walter J; Urban J; Volkwein C; Sommer T
Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p
EMBO Journal 20: 3124-3131 (2001-01-01)
Maurer P; Redd M; Solsbacher J; Bischoff FR; Greiner M; Podtelejnikov AV; Mann M; Stade K; Weis K; Schlenstedt G
The nuclear export receptor Xpo1p forms distinct complexes with NES transport substrates and the yeast ran binding protein 1 (Yrb1p)
Molecular Biology of the Cell 12 (3): 539-549 (2001-03)
Sommer T; Jarosch E; Lenk U
Compartment-specific functions of the ubiquitin-proteasome pathway
Reviews of Physiology Biochemistry and Pharmacology 142: 97-160 (2001-01-01)
Koehler M; Goerlich D; Hartmann E; Franke J
Adenoviral E1A protein nuclear import is preferentially mediated by importin alpha3 in vitro
Virology 289: 186-191 (2001-01-01)
Koehler M; Buchwalow IB; Alexander G; Christiansen M; Shagdarsuren E; Samoilova V; Hartmann E; Mervaala EMA; Haller H
Increased importin alpha protein expression in diabetic nephropathy
Kidney International 60: 2263-2273 (2001-01-01)
Koritschoner NP; Alvarez-Dolado M; Kurz SM; Heikenwaelder MF; Hacker C; Vogel F; Munoz A; Zenke M
Thyroid hormone regulates the obesity gene tub
EMBO Reports 2: 499-504 (2001-01-01)
Franke J; Reimann B; Hartmann E; Koehler M; Wiedmann B
Evidence for a nuclear passage of nascent polypeptide-associated complex subunits in yeast
Journal of Cell Science 114: 2641-2648 (2001-01-01)
Koehler M; Schneider W; Goebel U; Kettritz R
Renal anaemia of an unusual origin
Nephrology Dialysis Transplantation 16: 2263-2264 (2001-11-01)
2000
Sommer T
The ubiquitin system in yeast
Proteasomes: the World of Regulatory Proteolysis : 204-215 (2000-01-01)
Madruga J; Briegel K; Diebold S; Boehmelt G; Vogel F; Zenke M
Dendritic cells conditionally transformed by v-relER oncogene express lymphoid marker genes
Immunobiology 202: 394-407 (2000-11-01)
Meisinger C; Sommer T; Pfanner N
Purification of Saccharomcyes cerevisiae mitochondria devoid of microsomal and cytosolic contaminations
Analytical Biochemistry 287: 339-342 (2000-01-01)
Friedlander R; Jarosch E; Urban J; Volkwein C; Sommer T
A regulatory link between ER-associated protein degradation and the unfolded-protein response
Nature Cell Biology 2 (7): 379-384 (2000-07-01)
Lenk U; Sommer T
Ubiquitin-mediated proteolysis of a short lived regulatory protein depends on its cellular localization
Journal of Biological Chemistry 275: 39403-39410 (2000-01-01)
Solsbacher J; Maurer P; Vogel F; Schlenstedt G
Nup2p, a yeast nucleoporin, functions in bidirectional transport of importin alpha
Molecular and Cellular Biology 20 (22): 8468-8479 (2000-11-01)
1999
Welch K; Franke J; Koehler M; Macara IG
RanBP3 contains an unusual nuclear localization signal that is imported preferentially by importin-alpha3
Molecular and Cellular Biology 19: 8400-8411 (1999-12-01)
Sasnauskas K; Buzaite O; Vogel F; Jandrig B; Razanskas R; Staniulis J; Scherneck S; Kruger DH; Ulrich R
Yeast cells allow high-level expression and formation of polyomavirus-like particles
Biological Chemistry 380: 381-386 (1999-03-01)
Sandig G; Kaergel E; Menzel R; Vogel F; Zimmer T; Schunck WH
Regulation of endoplasmic reticulum biogenesis in response to cytochrome P450 overproduction
Drug Metabolism Reviews 31: 393-410 (1999-01-01)
Dumler I; Stepanova V; Jerke U; Mayboroda OA; Vogel F; Bouvet P; Tkachuk V; Haller H; Gulba DC
Urokinase-induced mitogenesis is mediated by casein kinase 2 and nucleolin
Current Biology 9: 1468-1476 (1999-01-01)
1998
Finley D; Tanaka K; Mann C; Feldmann H; Hochstrasser M; Vierstra R; Johnston S; Hampton R; Haber J; Mccusker J; Silver P; Frontali L; Thorsness P; Varshavsky A; Byers B; Madura K; Reed SI; Wolf D; Jentsch S; Sommer T; Baumeister W; Goldberg A; Fried V; Rubin DM; Toh-e A ·
Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle
Trends in Biochemical Sciences 23: 244-245 (1998-07-01)
1997
Biederer T; Volkwein C; Sommer T
Role of Cue1p in ubiquitination and degradition at the ER surface
Science 278 (5344): 1806-1809 (1997-12-05)
Zimmer T; Vogel F; Ohta A; Takagi M; Schunck WH
Protein quality - a determinant of the intracellular fate of membrane-bound cytochromes P450 in yeast
DNA and Cell Biology 16: 501-514 (1997-01-01)
Menzel R; Vogel F; Kaergel E; Schunck WH
Inducible membranes in yeast: relations to the unfolded-protein-response pathway
Yeast 13: 1211-1229 (1997-01-01)
Ikonomova R; Sommer T; Kepes F
The Srp40 protein plays a dose-sensitive role in preribosome assembly or transport and depends on its carboxy-terminal domain for proper localization to the yeast nucleoskeleton
DNA and Cell Biology 16: 1161-1173 (1997-01-01)
Plemper RK; Bohmler S; Bordallo J; Sommer T; Wolf DH
Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation
Nature 388: 891-895 (1997-01-01)
Collombet JM; Wheeler VC; Vogel F; Coutelle C
Introduction of plasmid DNA into isolated mitochondria by electroporation
Journal of Biological Chemistry 272: 5342-5347 (1997-01-01)
1996
Menzel R; Kaergel E; Vogel F; Boettcher C; Schunck WH
Topogenesis of a microsomal cytochrome P450 and induction of endoplasmic reticulum membrane proliferation in Saccharomyces cerevisiae
Archives of Biochemistry and Biophysics 330: 97-109 (1996-01-01)
Ruiz P; Brinkmann V; Ledermann B; Behrend M; Grund C; Thalhammer C; Vogel F; Birchmeier C; Guenthert U; Franke WW; Birchmeier W
Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart
Journal of Cell Biology 135 (1): 215-225 (1996-10)
Kaergel E; Menzel R; Honeck H; Vogel F; Boehmer A; Schunck WH
Candida maltosa NADPH-cytochrome P450 reductase: cloning of a full-length cDNA, heterologous expression in Saccharomyces cerevisiae and function of the N-terminal region for membrane anchoring and proliferation of the endoplasmic reticulum.
Yeast 12: 333-348 (1996-01-01)
Goerlich D; Kraft R; Kostka S; Vogel F; Hartmann E; Laskey RA; Mattaj IW; Izaurralde E
Importin provides a link between nuclear protein import and U snRNA export
Cell 87 (1): 21-32 (1996-10-04)
Finke K; Plath K; Panzner S; Prehn S; Rapoport TA; Hartmann E; Sommer T
A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S.cerevisiae
EMBO Journal 15 (7): 1482-1494 (1996-01-01)
Biederer T; Volkwein C; Sommer T
Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway
EMBO Journal 15: 2069-2076 (1996-01-01)
1995
Zimmer T; Kaminski K; Scheller U; Vogel F; Schunck WH
In vivo reconstitution of highly active Candida maltosa cytochrome P450 monooxygenase systems in inducible membranes of Saccharomyces cerevisiae
DNA and Cell Biology 14: 619-628 (1995-01-01)
Ohkuma M; Park SM; Zimmer T; Menzel R; Vogel F; Schunck WH; Ohta A; Takagi M
Proliferation of intracellular membrane structures upon homologous overproduction of cytochrome P-450 in Candida maltosa
Biochimica et Biophysica Acta 1236 (1): 163-169 (1995-01-01)
Monier S; Parton RG; Vogel F; Behlke J; Henske A; Kurzchalia TV
VIP21-Caveolin, a membrane protein constituent of the caveolar coat, oligomerizes in vivo and in vitro
Molecular Biology of the Cell 6 (7): 911-927 (1995-07)
Goerlich D; Vogel F; Mills AD; Hartmann E; Laskey RA
Distinct functions for the two importin subunits in nuclear protein import
Nature 377: 246-248 (1995-01-01)
1994
Menzel R; Kaergel E; Wolff C; Vogel F; Schunck WH
High level expression of integral membrane proteins induces proliferation of the endoplasmic reticulum
Cytochrome P450 : 307-310 (1994-01-01)
Micheel B; Heymann S; Scharte G; Boettger V; Vogel F; Duebel S; Breitling F; Little M; Behrsing O
Production of monoclonal antibodies against epitopes of the main coat protein of filamentous fd phages
Journal of Immunological Methods 71: 103-109 (1994-01-01)
Hartmann E; Sommer T; Prehn S; Goerlich D; Jentsch S; Rapoport TA
Evolutionary conservation of components of the protein translocation complex
Nature 367: 654-657 (1994-01-01)
1993
Jentsch S; Heinlein R; Jungmann J; Reins HA; Schlenker S; Seufert W; Sommer T; Springer S
Selective degradation by the ubiquitin system
Posttranscriptional control of gene expression : (1993-01-01)
Chen P; Johnson P; Sommer T; Jentsch S; Hochstrasser M
Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MATalpha2 repressor
Cell 74 (2): 357-369 (1993-07-30)
Sommer T; Jentsch S
A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum
Nature 365: 176-179 (1993-01-01)
Jentsch S; Hauser HP; Heinlein R; Jungmann J; Schlenker S; Seufert W; Sommer T; Springer S
Ubiquitin-dependent protein degradation
Protein synthesis and targeting in yeast : (1993-01-01)
1992
Vogel F; Mueller T; Grosse R
Is the mammary-derived growth inhibitor (MDGI) related 70 kD antigen, identified in nuclei, a nuclear receptor for MDGI or its hydrophobic ligands?
Histochemistry of Receptors : 159-163 (1992-01-01)
Jentsch S; Seufert W; Sommer T; Reins HA; Jungmann J; Hauser HP
Ubiquitin-dependent protein degradation
DNA replication and the cell cycle : (1992-01-01)
Vogel F; Gengnagel C; Kaergel E; Mueller H-G; Schunck WH
Immunocytochemical localization of alkane-inducible cytochrome P-450 and its NADPH-dependet reductase in the yeast Candida maltosa
European Journal of Cell Biology 57: 285-291 (1992-01-01)
Sommer T; Seufert W
Genetic analysis of ubiquitin-dependent protein degradation
Experientia 48: 172-178 (1992-02-15)
1991
Vogel F; Kaergel E; Schunck WH
In situ localization of cytochrome P-450, the first enzyme involved in aliphatic hydrocarbon degradation in the yeast Candida maltosa
Progress in Histochemistry and Cytochemistry 23: 383-389 (1991-01-01)
Schunck WH; Vogel F; Gross B; Kaergel E; Mauersberger S; Koepke K; Gengnagel C; Mueller H-G
Comparison of two cytochromes P-450 from Candida maltosa: primary structures, substrate specificities, and effects of their expression in Saccharomyces cerevisoae on the proliferation of the endoplasmic reticulum
European Journal of Cell Biology 55: 336-345 (1991-01-01)