Publications
2012
Schmidt V; Baum K; Lao A; Rateitschak K; Schmitz Y; Teichmann A; Wiesner B; Petersen CM; Nykjaer A; Wolf J; Wolkenhauer O; Willnow TE
Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease
EMBO Journal 31 (1): 187-200 (2012-01-04)
2011
Stuiver M; Lainez S; Will C; Terryn S; Guenzel D; Debaix H; Sommer K; Kopplin K; Thumfart J; Kampik NB; Querfeld U; Willnow TE; Nemec V; Wagner CA; Hoenderop JG; Devuyst O; Knoers NV; Bindels RJ; Meij IC; Mueller D
CNNM2, encoding a basolateral protein required for renal Mg(2+) handling, is mutated in dominant hypomagnesemia
American Journal of Human Genetics 88 (3): 333-343 (2011-03-11)
Vaegter CB; Jansen P; Fjorback AW; Glerup S; Skeldal S; Kjolby M; Richner M; Erdmann B; Nyengaard JR; Tessarollo L; Lewin GR; Willnow TE; Chao MV; Nykjaer A
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling
Nature Neuroscience 14 (1): 54-61 (2011-01)
2010
Joutel A; Monet-Lepretre M; Gosele C; Baron-Menguy C; Hammes A; Schmidt S; Lemaire-Carrette B; Domenga V; Schedl A; Lacombe P; Huebner N
Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease
Journal of Clinical Investigation 120 (2): 433-445 (2010-02-01)
Kjolby M; Andersen OM; Breiderhoff T; Fjorback AW; Pedersen KM; Madsen P; Jansen P; Heeren J; Willnow TE; Nykjaer A
Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export
Cell Metabolism 12 (3): 213-223 (2010-09-08)
2009
Ceccarini G; Flavell RR; Butelman ER; Synan M; Willnow TE; Bar-Dagan M; Goldsmith SJ; Kreek MJ; Kothari P; Vallabhajosula S; Muir TW; Friedman JM
PET imaging of leptin biodistribution and metabolism in rodents and primates
Cell Metabolism 10 (2): 148-159 (2009-08)
2008
Willnow TE; Petersen CM; Nykjaer A
VPS10P-domain receptors - regulators of neuronal viability and function
Nature Reviews Neuroscience 9 (12): 899-909 (2008-12)
2007
Jansen P; Giehl K; Nyengaard JR; Teng K; Lioubinski O; Sjoegaard SS; Breiderhoff T; Gotthardt M; Lin F; Eilers A; Petersen CM; Lewin GR; Hempstead BL; Willnow TE; Nykjaer A
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury
Nature Neuroscience 10 (11): 1449-1457 (2007-11)
Rogaeva E; Meng Y; Lee JH; Gu Y; Kawarai T; Zou F; Katayama T; Baldwin CT; Cheng R; Hasegawa H; Chen F; Shibata N; Lunetta KL; Pardossi-Piquard R; Bohm C; Wakutani Y; Cupples LA; Cuenco KT; Green RC; Pinessi L; Rainero I; Sorbi S; Bruni A; Duara R; Friedland RP; Inzelberg R; Hampe W; Bujo H; Song YQ; Andersen OM; Willnow TE; Graff-Radford N; Petersen RC; Dickson D; Der SD; Fraser PE; Schmitt-Ulms G; Younkin S; Mayeux R; Farrer LA; St George-Hyslop P
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
Nature Genetics 39 (2): 168-177 (2007-02)
2006
Donath S; Li P; Willenbockel C; Al-Saadi N; Gross V; Willnow TE; Bader M; Martin U; Bauersachs J; Wollert KC; Dietz R; von Harsdorf R
Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress
Circulation 113: 1203-1212 (2006-02-27)
Andersen OM; Willnow TE
Lipoprotein receptors in Alzheimer's disease
Trends in Neurosciences 29 (12): 687-694 (2006-12)
2005
Andersen OM; Reiche J; Schmidt V; Gotthardt M; Spoelgen R; Behlke J; von Arnim CAF; Breiderhoff T; Jansen P; Wu X; Bales KR; Cappai R; Masters CL; Gliemann J; Mufson EJ; Hyman BT; Paul SM; Nykjaer A; Willnow TE
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein
Proceedings of the National Academy of Sciences of the United States of America 102: 13461-13466 (2005-09-07)
Hammes A; Andreassen TK; Spoelgen R; Raila J; Huebner N; Schulz H; Metzger J; Schweigert FJ; Luppa PB; Nykjaer A; Willnow TE
Role of endocytosis in cellular uptake of sex steroids
Cell 122: 751-762 (2005-09-09)
2004
Nykjaer A; Lee R; Teng KK; Jansen P; Madsen P; Nielsen MS; Jacobsen C; Kliemannel M; Schwarz E; Willnow TE; Hempstead BL; Petersen CM
Sortilin is essential for proNGF-induced neuronal cell death
Nature 427 (6977): 843-848 (2004-02-26)
2003
Lisi S; Pinchera A; McCluskey RT; Willnow TE; Refetoff S; Marcocci C; Vitti P; Menconi F; Grasso L; Luchetti F; Collins AB; Marino M
Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: A control mechanism for thyroid hormone release
Proceedings of the National Academy of Sciences of the United States of America 100: 14858-14863 (2003-01-01)
2002
Nykjaer A; Willnow TE
The low-density lipoprotein receptor gene family: a cellular Swiss army knife?
Trends in Cell Biology 12 (6): 273-280 (2002-01-01)
2001
Nykjaer A; Fyfe JC; Kozyraki R; Leheste JR; Jacobsen C; Nielsen MS; Verroust PJ; Aminoff M; de la Chapelle A; Moestrup SK; Ray R; Gliemann J; Willnow TE; Christensen EI
Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D-3
Proceedings of the National Academy of Sciences of the United States of America 98: 13895-13900 (2001-01-01)
Kozyraki R; Fyfe J; Verroust PJ; Jacobsen C; Dautry-Varsat A; Gburek J; Willnow TE; Christensen EI; Moestrup SK
Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia
Proceedings of the National Academy of Sciences of the United States of America 98: 12491-12496 (2001-01-01)
2000
Birn H; Fyfe JC; Jacobsen C; Mounier F; Verroust PJ; Orskov H; Willnow TE; Moestrup SK; Christensen EI
Cubilin is an albumin binding protein important for renal tubular albumin reabsorption
Journal of Clinical Investigation 105 (10): 1353-1361 (2000-05)
1999
Nykjaer A; Dragun D; Walther D; Vorum H; Jacobsen C; Herz J; Melsen F; Christensen EI; Willnow TE
An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D-3
Cell 96 (4): 507-515 (1999-02-19)
1997
Herz J; Willnow TE; Farese RV
Cholesterol, hedgehog and embryogenesis
Nature Genetics 15 (2): 123-124 (1997-02)
1996
Sinnis P; Willnow TE; Briones MR; Herz J; Nussenzweig V
Remnant lipoproteins inhibit malaria sporozoite invasion of hepatocytes
Journal of Experimental Medicine 184 (3): 945-954 (1996-09-01)
Willnow TE; Hilpert J; Armstrong SA; Rohlmann A; Hammer RE; Burns DK; Herz J
Defective forebrain development in mice lacking gp330/megalin
Proceedings of the National Academy of Sciences of the United States of America 93 (16): 8460-8464 (1996-08-06)
Willnow TE; Rohlmann A; Horton J; Otani H; Braun JR; Hammer RE; Herz J
RAP, a specialized chaperone, prevents ligand-induced er retention and degradation of LDL receptor-related endocytic receptors
EMBO Journal 15 (11): 2632-2639 (1996-01-01)
1995
Willnow TE; Armstrong SA; Hammer RE; Herz J
Functional expression of low density lipoprotein receptor- related protein is controlled by receptor-associated protein in vivo
Proceedings of the National Academy of Sciences of the United States of America 92 (10): 4537-4541 (1995-05-09)
1994
Willnow TE; Sheng Z; Ishibashi S; Herz J
Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist
Science 264 (5164): 1471-1474 (1994-06-03)