Publications
2012
Spranger S; Jeremias I; Wilde S; Leisegang M; Stärck L; Mosetter B; Uckert W; Heemskerk MH; Schendel DJ; Frankenberger B
T-cell receptor-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo
Blood 119 (15): 3440-3449 (2012-04-12)
2011
Seifert S; Pannell M; Uckert W; Faerber K; Kettenmann H
Transmitter- and hormone-activated Ca(2+) responses in adult microglia/brain macrophages in situ recorded after viral transduction of a recombinant Ca(2+) sensor
Cell Calcium 49 (6): 365-375 (2011-06)
Popovic J; Li LP; Kloetzel PM; Leisegang M; Uckert W; Blankenstein T
The only proposed T-cell epitope derived from the TEL-AML1 translocation is not naturally processed
Blood 118 (4): 946-954 (2011-07-28)
Briesemeister D; Sommermeyer D; Loddenkemper C; Loew R; Uckert W; Blankenstein T; Kammertoens T
Tumor rejection by local interferon gamma induction in established tumors is associated with blood vessel destruction and necrosis
International Journal of Cancer 128 (2): 371-378 (2011-01-15)
2010
Leisegang M; Wilde S; Spranger S; Milosevic S; Frankenberger B; Uckert W; Schendel DJ
MHC-restricted fratricide of human lymphocytes expressing survivin-specific transgenic T cell receptors
Journal of Clinical Investigation 120 (11): 3869-3877 (2010-11-01)
Merz H; Kaehler C; Hoefig KP; Branke B; Uckert W; Nadrowitz R; Cerny-Reiterer S; Herrmann H; Feller AC; Valent P
Interleukin-9 (IL-9) and NPM-ALK each generate mast cell hyperplasia as single 'hit' and cooperate in producing a mastocytosis-like disease in mice
Oncotarget 1 (2): 104-119 (2010-06)
Sommermeyer D; Uckert W
Minimal amino acid exchange in human TCR constant regions fosters improved function of TCR gene-modified T cells
Journal of Immunology 184 (11): 6223-6231 (2010-06-01)
Meyerhuber P; Conrad H; Staerck L; Leisegang M; Busch DH; Uckert W; Bernhard H
Targeting the epidermal growth factor receptor (HER) family by T cell receptor gene-modified T lymphocytes
Journal of Molecular Medicine 88 (11): 1113-1121 (2010-11)
Leisegang M; Turqueti-Neves A; Engels B; Blankenstein T; Schendel DJ; Uckert W; Noessner E
T-cell receptor gene-modified T cells with shared renal cell carcinoma specificity for adoptive T-cell therapy
Clinical Cancer Research 16 (8): 2333-2343 (2010-04-15)
Liang X; Weigand LU; Schuster IG; Eppinger E; van der Griendt JC; Schub A; Leisegang M; Sommermeyer D; Anderl F; Han Y; Ellwart J; Moosmann A; Busch DH; Uckert W; Peschel C; Krackhardt AM
A single TCR{alpha}-chain with dominant peptide recognition in the allorestricted HER2/neu-specific T cell repertoire
Journal of Immunology 184 (3): 1617-1629 (2010-02-01)
Kieback E; Uckert W
Enhanced T cell receptor gene therapy for cancer
Expert Opinion on Biological Therapy 10 (5): 749-762 (2010-05)
Buening H; Uckert W; Cichutek K; Hawkins RE; Abken H
Do CARs need a driver's license? Adoptive cell therapy with chimeric antigen receptor-redirected T cells caused serious adverse events
Human Gene Therapy 21 (9): 1039-1042 (2010-09)
Bendle GM; Linnemann C; Hooijkaas AI; Bies L; de Witte MA; Jorritsma A; Kaiser AD; Pouw N; Debets R; Kieback E; Uckert W; Song JY; Haanen JB; Schumacher TN
Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy
Nature Medicine 16 (5): 565-570, 1p following 570 (2010-05)
2009
Uckert W; Schumacher TN
TCR transgenes and transgene cassettes for TCR gene therapy: status in 2008
Cancer Immunology Immunotherapy 58 (5): 809-822 (2009-05)
Wilde S; Sommermeyer D; Frankenberger B; Schiemann M; Milosevic S; Spranger S; Pohla H; Uckert W; Busch DH; Schendel DJ
Dendritic cells pulsed with RNA encoding allogeneic MHC and antigen induce T cells with superior antitumor activity and higher TCR functional avidity
Blood 114 (10): 2131-2139 (2009-09-03)
Rueder C; Hoepken UE; Wolf J; Mittruecker HW; Engels B; Erdmann B; Wollenzin S; Uckert W; Doerken B; Rehm A
The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells
Journal of Clinical Investigation 119 (8): 2184-2203 (2009-08)
2008
Walzlein JH; Synowitz M; Engels B; Markovic DS; Gabrusiewicz K; Nikolaev E; Yoshikawa K; Kaminska B; Kempermann G; Uckert W; Kaczmarek L; Kettenmann H; Glass R
The antitumorigenic response of neural precursors depends on subventricular proliferation and age
Stem Cells 26 (11): 2945-2954 (2008-11)
Kieback E; Charo J; Sommermeyer D; Blankenstein T; Uckert W
A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer
Proceedings of the National Academy of Sciences of the United States of America 105 (2): 623-628 (2008-01-15)
Leisegang M; Engels B; Meyerhuber P; Kieback E; Sommermeyer D; Xue SA; Reuss S; Stauss H; Uckert W
Enhanced functionality of T cell receptor-redirected T cells is defined by the transgene cassette
Journal of Molecular Medicine 86 (5): 573-583 (2008-05)
2007
Reuss S; Biese P; Cosset FL; Takeuchi Y; Uckert W
Suspension packaging cell lines for the simplified generation of T-cell receptor encoding retrovirus vector particles
Gene Therapy 14 (7): 595-603 (2007-04)
Engels B; Uckert W
Redirecting T lymphocyte specificity by T cell receptor gene transfer - a new era for immunotherapy
Molecular Aspects of Medicine 28 (1): 115-142 (2007-02)
McNicol AM; Bendle G; Holler A; Matjeka T; Dalton E; Rettig L; Zamoyska R; Uckert W; Xue SA; Stauss HJ
CD8alpha/alpha homodimers fail to function as co-receptor for a CD8-dependent TCR
European Journal of Immunology 37: 1634-1641 (2007-05-15)
Nassenstein C; Kammertoens T; Veres TZ; Uckert W; Spies E; Fuchs B; Krug N; Braun A
Neuroimmune crosstalk in asthma: Dual role of the neurotrophin receptor p75NTR
Journal of Allergy and Clinical Immunology 120(5): 1089-1096 (2007-08-21)
Weinhold M; Sommermeyer D; Uckert W; Blankenstein T
Dual T cell receptor expressing CD8+ T cells with tumor- and self-specificity can inhibit tumor growth without causing severe autoimmunity
Journal of Immunology 179 (8): 5534-5542 (2007-10-15)
2006
Mathas S; Janz M; Hummel F; Hummel M; Wollert-Wulf B; Lusatis S; Anagnostopoulos I; Lietz A; Sigvardsson M; Jundt F; Joehrens K; Bommert K; Stein H; Doerken B
Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma
Nature Immunology 7 (2): 207-215 (2006-02)
Kieback E; Mueller M
Factors influencing subcellular localization of the human papillomavirus L2 minor structural protein
Virology 345: 199-208 (2006-02-05)
Bleifuss E; Kammertoens T; Hutloff A; Quarcoo D; Dorner M; Straub P; Uckert W; Hildt E
The translocation motif of hepatitis B virus improves protein vaccination
Cellular and Molecular Life Sciences 63: 627-635 (2006-02-16)
Sommermeyer D; Neudorfer J; Weinhold M; Leisegang M; Engels B; Noessner E; Heemskerk MH; Charo J; Schendel DJ; Blankenstein T; Bernhard H; Uckert W
Designer T cells by T cell receptor replacement
European Journal of Immunology 36 (11): 3052-3059 (2006-11)
Bandapalli OR; Geheeb M; Kobelt D; Kuehnle K; Elezkurtaj S; Herrmann J; Gressner AM; Weiskirchen R; Beule D; Bluethgen N; Herzel H; Franke C; Brand K
Global analysis of host tissue gene expression in the invasive front of colorectal liver metastases
International Journal of Cancer 118: 74-89 (2006-01-01)
2005
Hieronymus T; Gust TC; Kirsch RD; Jorgas T; Blendinger G; Goncharenko M; Supplitt K; Rose-John S; Mueller AM; Zenke M
Progressive and controlled development of mouse dendritic cells from Flt3+ CD11b+ progenitors in vitro
Journal of Immunology 174: 2552-2562 (2005-01-01)
Xue SA; Gao L; Hart D; Gillmore R; Qasim W; Thrasher A; Apperley J; Engels B; Uckert W; Morris E; Stauss HJ
Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene transduced human T cells
Blood 106: 3062-3067 (2005-07-14)
Uckert W; Blankenstein T
Gentherapie mit T-Zellrezeptor modifizierten Zellen
BioForum 28 (3): 27-30 (2005-05-20)
Engels B; Noessner E; Frankenberger B; Blankenstein T; Schendel DJ; Uckert W
Redirecting human T lymphocytes toward renal cell carcinoma specificity by retroviral transfer of T cell receptor genes
Human Gene Therapy 16: 799-810 (2005-07-01)
Kammertoens T; Willebrand R; Erdmann B; Li L; Li Y; Engels B; Uckert W; Blankenstein T
CY15, a malignant histiocytic tumor that is phenotypically similar to immature dendritic cells
Cancer Research 65: 2560-2564 (2005-01-01)
2004
Wuest T; Both GW; Prince AM; Hofmann C; Loeser P
Recombinant ovine atadenovirus induces a strong and sustained T cell response against the hepatitis C virus NS3 antigen in mice
Vaccine 22: 2717-2721 (2004-01-01)
Elezkurtaj S; Kopitz C; Baker AH; Perez-Canto A; Arlt MJ; Khokha R; Gansbacher B; Anton M; Brand K; Krueger A
Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinases-1 in the liver: efficient protection against T-cell lymphoma and colon carcinoma metastasis
Journal of Gene Medicine 6: 1228-1237 (2004-09-23)
Uckert W; Salmons B; Beltinger C; Guenzburg WH; Kammertoens T
Combination suicide gene therapy
Suicide Gene Therapy : Methods and Reviews : 345-352 (2004-01-01)
Cichon G; Willnow TE; Herwig S; Uckert W; Loeser P; Schmidt HH; Benhidjeb T; Schlag PM; Schnieders F; Niedzielska D; Heeren J
Non-physiological overexpression of the low density lipoprotein receptor (LDLr) gene in the liver induces pathological intracellular lipid and cholesterol storage
Journal of Gene Medicine 6: 166-175 (2004-01-01)
Tietge UJF; Cichon G; Buettner C; Genschel J; Heeren J; Gielow P; Grewe N; Dogar M; Beisiegel U; Manns MP; Lochs H; Burchert W; Schmidt HHJ
A sensitive noninvasive method for monitoring successful liver-directed gene transfer of the low-density lipoprotein receptor in Watanabe hyperlipidemic rabbits in vivo
Gene Therapy 11: 574-580 (2004-01-01)
Kuemin D; Hofmann C; Uckert W; Both GW; Loeser P
Identification of an ovine atadenovirus gene whose product activates the viral E2 promoter: possible involvement of E2F-1
Virology 318: 79-89 (2004-01-01)
Gladow M; Uckert W; Blankenstein T
Dual T cell receptor T cells with two defined specificities mediate tumor suppression via both receptors
European Journal of Immunology 34: 1882-1891 (2004-07-01)
2003
Cichon G; Boeckh-Herwig S; Kuemin D; Hoffmann C; Schmidt HH; Wehnes E; Haensch W; Schneider U; Eckhardt U; Burger R; Pring-Akerblom P
Titer determination of Ad5 in blood: a cautionary note
Gene Therapy 10: 1012-1017 (2003-01-01)
Merz H; Lange K; Nadrowitz R; Uckert W; Blankenstein T; Feller AC
Die Ueberexpression von NPM-ALK in haematopoietischen Stammzellen induziert verschiedene maligne Non-Hodgkin-Lymphome in der IL-9 transgenen Maus [Overexpression of NPM-ALK induces different types of malignant lymphomas in IL-9 transgenic mice]
Verhandlungen der Deutschen Gesellschaft fuer Pathologie 87: 224-231 (2003-01-01)
Loeser P; Hofmann C; Both GW; Uckert W; Hillgenberg M
Construction, rescue, and characterization of vectors derived from ovine atadenovirus
Journal of Virology 77: 11941-11951 (2003-01-01)
Engels B; Cam H; Schueler T; Indraccolo S; Gladow M; Baum C; Blankenstein T; Uckert W
Retroviral vectors for high-level transgene expression in T lymphocytes
Human Gene Therapy 14: 1155-1168 (2003-01-01)
Lange K; Uckert W; Blankenstein T; Nadrowitz R; Bittner C; Renauld JC; van Snick J; Feller AC; Merz H
Overexpression of NPM-ALK induces different types of malignant lymphomas in IL-9 transgenic mice
Oncogene 22: 517-527 (2003-01-01)
Muehlebach MD; Schmitt I; Steidl S; Stitz J; Schweizer M; Blankenstein T; Cichutek K; Uckert W
Transduction efficiency of MLV but not of HIV-1 vectors is pseudotype dependent on human primary T lymphocytes
Journal of Molecular Medicine 81: 801-810 (2003-01-01)
2002
Cichon G; Boeckh-Herwig S; Elezkurtaj S; Schmidt HH; Hofmann C; Arnold W
Hepatocarcinoma cells constitutively expressing adenoviral E1-genes provide a tumor model for intratumoral replication of E1-deficient adenoviruses
Anticancer Research 22 (1A): 197-201 (2002-01-01)
Koehler NK; Genain CP; Giesser B; Hauser SL
The human T cell response to myelin oligodendrocyte glycoprotein: a multiple sclerosis family-based study
Journal of Immunology 168: 5920-5927 (2002-06-01)
Kuemin D; Hofmann C; Rudolph M; Both GW; Loeser P
Biology of ovine adenovirus infection of nonpermissive cells
Journal of Virology 76: 10882-10893 (2002-11-01)
2001
Beltinger C; Uckert W; Debatin KM
Suicide gene therapy for pediatric tumors
Journal of Molecular Medicine 78: 598-612 (2001-01-01)
Cichon G; Boeckh-Herwig S; Schmidt HH; Wehnes E; Mueller T; Pring-Akerblom P; Burger R
Complement activation by recombinant adenoviruses
Gene Therapy 8: 1794-1800 (2001-12-01)
2000
Indraccolo S; Minuzzo S; Habeler W; Zamarchi R; Fregonese A; Guenzburg WH; Salmons B; Uckert W; Chieco-Bianchi L; Amadori A
Modulation of moloney leukemia virus long terminal repeat transcriptionalactivity by the murine CD4 silencer in retroviral vectors
Virology 276: 83-92 (2000-01-01)
Gladow M; Becker C; Blankenstein T; Uckert W
MLV-10A1 retrovirus pseudotype efficiently transduces primary human CD4+ T lymphocytes
Journal of Gene Medicine 2: 409-415 (2000-01-01)
Loeser P; Hillgenberg M; Arnold W; Both GW; Hofmann C
Ovine adenovirus vectors mediate efficient gene transfer to skeletal muscle
Gene Therapy 7: 1491-1498 (2000-09-01)
Stitz J; Buchholz CJ; Engelstaedter M; Uckert W; Bloemer U; Schmitt I; Cichutek K
Lentiviral vectors pseudotyped with envelope glycoproteins derived from gibbon ape leukemia virus and murine leukemia virus 10A1
Virology 273: 16-20 (2000-01-01)
Uckert W; Pedersen L; Guenzburg W
Green fluorescent protein retroviral vector. Generation of high-titer producer cells and virus supernatant
Gene Therapy of Cancer : Methods and Protocols : 275-285 (2000-01-01)
Ott M; Schmidt HHJ; Cichon G; Manns MP
Emerging therapies in hepatology: Liver-directed gene transfer and hepatocyte transplantation
Cells Tissues Organs 167: 81-87 (2000-01-01)
Beltinger C; Fulda S; Kammertoens T; Uckert W; Debatin KM
Mitochondrial amplification of death signals determines thymidine kinase/ ganciclovir-triggered activation of apoptosis
Cancer Research 60: 3212-3217 (2000-01-01)
Uckert W; Becker C; Gladow M; Klein D; Kammertoens T; Pedersen L; Blankenstein T
Efficient gene transfer into primary human CD8+ T lymphocytes by MuLV-10A1 retrovirus pseudotype
Human Gene Therapy 11: 1005-1014 (2000-01-01)
Kammertoens T; Gelbmann W; Karle P; Alton K; Saller R; Salmons B; Guenzburg WH; Uckert W
Combined chemotherapy of murine mammary tumors by local activation of the prodrugs ifosfamide and 5-fluorocytosine
Cancer Gene Therapy 7: 629-636 (2000-04-01)
1999
Cichon G; Strauss M
Gene Therapy of Familial Hypercholesterolemia
Gene therapy :Principles and Applications : 151-167 (1999-01-01)
Heeren J; Steinwaerder DS; Schnieders F; Cichon G; Strauss M; Beisiegel U
Nonphysiological overexpression of low-density lipoprotein receptors causes pathological intracellular lipid accumulation and the formation of cholesterol and cholesteryl ester crystals in vitro
Journal of Molecular Medicine 77: 735-743 (1999-10-01)
Beltinger C; Fulda S; Kammertoens T; Meyer E; Uckert W; Debatin KM
Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases
Proceedings of the National Academy of Sciences of the United States of America 96: 8699-8704 (1999-07-20)
Hofmann C; Loeser P; Cichon G; Arnold W; Both GW; Strauss M
Ovine adenovirus vectors overcome preexisting humoral immunity against human adenoviruses in vivo
Journal of Virology 73: 6930-6936 (1999-08-01)
Cichon G; Schmidt HH; Benhidjeb T; Loeser P; Ziemer S; Haas R; Grewe N; Schnieders F; Heeren J; Manns MP; Schlag PM; Strauss M
Intravenous administration of recombinant adenoviruses causes thrombocytopenia, anemia and erythroblastosis in rabbits
Journal of Gene Medicine 1: 360-371 (1999-09-01)
1998
Uckert W; Willimsky G; Pedersen FS; Blankenstein T; Pedersen L
RNA levels of human retrovirus receptors Pit 1 and Pit 2 do not correlate with infectibility by three retroviral vector pseudotypes
Human Gene Therapy 9: 2619-2627 (1998-01-01)
Uckert W; Walther W; Stein U
Large and small scale RNA preparations from eucaryotic cells
RNA Isolation and Characterization Protocols : 7-14 (1998-01-01)
Cichon G; Strauss M
Transient immunosuppression with 15-deoxyspergualin prolongs reporter gene expression and reduces humoral immune response after adenoviral gene transfer
Gene Therapy 5: 85-90 (1998-01-01)
Uckert W; Kammertoens T; Haack K; Qin Z; Gebert J; Schendel DJ; Blankenstein T
Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo
Human Gene Therapy 9: 855-865 (1998-01-01)