Publications
2012
Tappe-Theodor A; Constantin CE; Tegeder I; Lechner SG; Langeslag M; Lepcynzsky P; Wirotanseng RI; Kurejova M; Agarwal N; Nagy G; Todd A; Wettschureck N; Offermanns S; Kress M; Lewin GR; Kuner R
G{alpha}(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization
Pain 153 (1): 184-196 (2012-01)
2011
Lechner SG; Markworth S; Poole K; Smith ES; Lapatsina L; Frahm S; May M; Pischke S; Suzuki M; Ibanez-Tallon I; Luft FC; Jordan J; Lewin GR
The molecular and cellular identity of peripheral osmoreceptors
Neuron 69 (2): 332-344 (2011-01-27)
Gangadharan V; Wang R; Ulzhoefer B; Luo C; Bardoni R; Bali KK; Agarwal N; Tegeder I; Hildebrandt U; Nagy GG; Todd AJ; Ghirri A; Haeussler A; Sprengel R; Seeburg PH; Macdermott AB; Lewin GR; Kuner R
Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice
Journal of Clinical Investigation 121 (4): 1608-1623 (2011-04-01)
Lechner SG; Siemens J
Sensory transduction, the gateway to perception: mechanisms and pathology
EMBO Reports 12 (4): 292-295 (2011-04-01)
Vaegter CB; Jansen P; Fjorback AW; Glerup S; Skeldal S; Kjolby M; Richner M; Erdmann B; Nyengaard JR; Tessarollo L; Lewin GR; Willnow TE; Chao MV; Nykjaer A
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling
Nature Neuroscience 14 (1): 54-61 (2011-01)
Wang R; Lewin GR
The Cav3.2 T-type calcium channel regulates temporal coding in mouse mechanoreceptors
Journal of Physiology 589 (9): 2229-2243 (2011-05-01)
Lapatsina L; Brand J; Poole K; Daumke O; Lewin GR
Stomatin-domain proteins
European Journal of Cell Biology : (2011-04-16)
Smith ES; Omerbasic D; Lechner SG; Anirudhan G; Lapatsina L; Lewin GR
The molecular basis of acid insensitivity in the African naked mole-rat
Science 334 (6062): 1557-1560 (2011-12-16)
Chiang LY; Poole K; Oliveira BE; Duarte N; Bernal Sierra YA; Bruckner-Tuderman L; Koch M; Hu J; Lewin GR
Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons
Nature Neuroscience 14 (8): 993-1000 (2011-07-03)
Heidenreich M; Lechner SG; Vardanyan V; Wetzel C; Cremers CW; De Leenheer EM; Aranguez G; Moreno-Pelayo MA; Jentsch TJ; Lewin GR
KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man
Nature Neuroscience 15 (1): 138-145 (2011-11-20)
2010
Smith ES; Blass GR; Lewin GR; Park TJ
Absence of histamine-induced itch in the African naked mole-rat and "rescue" by Substance P
Molecular Pain 6 (1): 29 (2010-05-24)
Brand A; Smith ES; Lewin GR; Park TJ
Functional neurokinin and NMDA receptor activity in an animal naturally lacking Substance P: the naked mole-rat
PLoS ONE 5 (12): e15162 (2010-12-21)
Bishop T; Marchand F; Young AR; Lewin GR; McMahon SB
Ultraviolet-B-induced mechanical hyperalgesia: A role for peripheral sensitisation
Pain 150 (1): 141-152 (2010-07)
Stuerzebecher AS; Hu J; Smith ESJ; Frahm S; Santos-Torres J; Kampfrath B; Auer S; Lewin GR; Ibanez-Tallon I
An in vivo tethered toxin approach for the cell-autonomous inactivation of voltage-gated sodium channel currents in nociceptors
Journal of Physiology 588 (Pt 10): 1695-1707 (2010-05-15)
Hu J; Chiang LY; Koch M; Lewin GR
Evidence for a protein tether involved in somatic touch
EMBO Journal 29 (4): 855-867 (2010-02-17)
2009
Lechner SG; Lewin GR
Peripheral sensitisation of nociceptors via G-protein dependent potentiation of mechanotransduction currents
Journal of Physiology 587 (Pt 14): 3493-3503 (2009-07-15)
Smith ES; Lewin GR
Nociceptors: a phylogenetic view
Journal of Comparative Physiology A 195 (12): 1089-1106 (2009-12)
Lechner SG; Frenzel H; Wang R; Lewin GR
Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development
EMBO Journal 28 (10): 1479-1491 (2009-05-20)
2008
Park TJ; Lu Y; Juettner R; Smith ESJ; Hu J; Brand A; Wetzel C; Milenkovic N; Erdmann B; Heppenstall PA; Laurito CE; Wilson SP; Lewin GR
Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber)
PLoS Biology 6 (1): e13 (2008-01)
Milenkovic N; Wetzel C; Moshourab R; Lewin GR
Speed and temperature dependence of mechanotransduction in in afferent fibers recorded from the mouse saphenous nerve
Journal of Neurophysiology 100 (5): 2771-2783 (2008-11)
Ludwig T; Kirmse R; Poole K; Schwarz US
Probing cellular microenvironments and tissue remodeling by atomic force microscopy
Pfluegers Archiv European Journal of Physiology 456 (1): 29-49 (2008-04)
Smith ES; Momin A
Persistent pain: the contribution of NaV1.9
Journal of Physiology 586 (9): 2249-2250 (2008-05-01)
Lewin GR
Stretching it for pain
Pain 137 (1): 3-4 (2008-07)
2007
Wetzel C; Hu J; Riethmacher D; Benckendorff A; Harder L; Eilers A; Moshourab R; Kozlenkov A; Labuz D; Caspani O; Erdmann B; Machelska H; Heppenstall PA; Lewin GR
A stomatin-domain protein essential for touch sensation in the mouse
Nature 445 (7124): 206-209 (2007-01-11)
Milenkovic N; Frahm C; Gassmann M; Griffel C; Erdmann B; Birchmeier C; Lewin GR; Garratt AN
Nociceptive tuning by stem cell factor/c-Kit signaling
Neuron 56 (5): 893-906 (2007-12-06)
Jansen P; Giehl K; Nyengaard JR; Teng K; Lioubinski O; Sjoegaard SS; Breiderhoff T; Gotthardt M; Lin F; Eilers A; Petersen CM; Lewin GR; Hempstead BL; Willnow TE; Nykjaer A
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury
Nature Neuroscience 10 (11): 1449-1457 (2007-11)
Martinez-Salgado C; Benckendorff AG; Chiang LY; Wang R; Milenkovic N; Wetzel C; Hu J; Stucky CL; Parra MG; Mohandas N; Lewin GR
Stomatin and sensory neuron mechanotransduction
Journal of Neurophysiology 98 (6): 3802-3808 (2007-12)
2006
Hu J; Lewin GR
Mechanosensitive currents in the neurites of cultured mouse sensory neurones
Journal of Physiology 577 (Pt.3): 815-828 (2006-12-15)
Boensch R; Lewin GR
Finding sensory neuron mechanotransduction components
The Nociceptive Membrane : 379-414 (2006-08-01)
Hu J; Milenkovic N; Lewin GR
The high threshold mechanotransducer: A status report
Pain 120 (1-2): 3-7 (2006-01)
Heppenstall PA; Lewin GR
A role for T-type Ca2+ channels in mechanosensation
Cell Calcium 40 (2): 165-174 (2006-08)
2005
McIlwrath SL; Hu J; Anirudhan G; Shin JB; Lewin GR
The sensory mechanotransduction ion channel ASIC2 (acid sensitive ion channel 2) is regulated by neurotrophin availability
Neuroscience 131: 499-511 (2005-01-01)
2004
Lewin GR; Lu Y; Park TJ
A plethora of painful molecules [Erratum in: Curr Opin Neurobiol. vol 15, pg 129, 2005]
Current Opinion in Neurobiology 14: 443-449 (2004-08-01)
Page AJ; Brierley SM; Martin CM; Martinez-Salgado C; Wemmie JA; Brennan TJ; Symonds E; Omari T; Lewin GR; Welsh MJ; Blackshaw LA
The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function
Gastroenterology 127: 1739-1747 (2004-01-01)
Lewin GR; Moshourab R
Mechanosensation and pain
Journal of Neurobiology 61: 30-44 (2004-01-01)
Hartmann B; Ahmadi S; Heppenstall PA; Lewin GR; Schott C; Borchardt T; Seeburg PH; Zeilhofer HU; Sprengel R; Kuner R
The AMPA receptor subunits GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory pain
Neuron 44: 637-650 (2004-11-18)
Dubreuil AS; Boukhaddaoui H; Desmadryl G; Martinez-Salgado C; Moshourab R; Lewin GR; Carroll P; Valmier J; Scamps F
Role of T-type calcium current in identified D-hair mechanoreceptor neurons studied in vitro
Journal of Neuroscience 24 (39): 8480-8484 (2004-09-29)
2003
Lucius H; Friedrichson T; Kurzchalia TV; Lewin GR
Identification of caveolae-like structures on the surface of intact cells using scanning force microscopy
Journal of Membrane Biology 194: 97-108 (2003-01-01)
Shin JB; Martinez-Salgado C; Heppenstall PA; Lewin GR
A T-type calcium channel required for normal function of a mammalian mechanoreceptor
Nature Neuroscience 6: 724-730 (2003-01-01)
Winter J; Lehmann T; Suckow V; Kijas Z; Kulozik A; Kalscheuer V; Hamel B; Devriendt K; Opitz J; Lenzner S; Ropers HH; Schweiger S
Duplication of the MID1 first exon in a patient with Opitz G/BBB syndrome
Human Genetics 112: 249-254 (2003-01-01)
2002
Mueller T; Brohmann H; Pierani A; Heppenstall PA; Lewin GR; Jessell TM; Birchmeier C
The homeodomain factor Lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord
Neuron 34 (4): 551-562 (2002-01-01)
Stucky CL; Shin JB; Lewin GR
Neurotrophin-4: a survival factor for adult sensory neurons
Current Biology 12: 1401-1404 (2002-08-20)
Stucky CL; Rossi J; Airaksinen MS; Lewin GR
GFR alpha2/neurturin signalling regulates noxious heat transduction in isolectin B4- binding mouse sensory neurons
Journal of Physiology 545: 43-50 (2002-01-01)
Schmidt H; Werner M; Heppenstall PA; Henning M; More MI; Kuehbandner S; Lewin GR; Hofmann F; Feil R; Rathjen FG
cGMP-mediated signaling via cGKI�s required for the guidance and connectivity of sensory axons
Journal of Cell Biology 159 (3): 489-498 (2002-11-11)
Postigo A; Calella AM; Fritzsch B; Knipper M; Katz D; Eilers A; Schimmang T; Lewin GR; Klein R; Minichiello L
Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons
Genes & Development 16: 633-645 (2002-01-01)
2001
Price MP; McIlwrath SL; Xie JH; Cheng C; Qiao J; Tarr DE; Sluka KA; Brennan TJ; Lewin GR; Welsh MJ
The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice
Neuron 32 (6): 1071-1083 (2001-12-20)
Heppenstall PA; Lewin GR
BDNF but not NT-4 is required for normal flexion reflex plasticity and function
Proceedings of the National Academy of Sciences of the United States of America 98: 8107-8112 (2001-07-03)
Hamilton SG; McMahon SB; Lewin GR
Selective activation of nociceptors by P2X receptor agonists in normal and inflamed rat skin
Journal of Physiology 534: 437-445 (2001-01-01)
Roosen A; Schober A; Strelau J; Boettner M; Faulhaber J; Bendner G; McIlwrath SL; Seller H; Ehmke H; Lewin GR; Unsicker K
Lack of neurotrophin-4 causes selective structural and chemical deficits in sympathetic ganglia and their preganglionic innervation
Journal of Neuroscience 21 (9): 3073-3084 (2001-05-01)
2000
Heppenstall PA; Lewin GR
Neurotrophins, nociceptors and pain
Current Opinion in Anaesthesiology 13 (5): 573-576 (2000-10)
Pesquero JB; Araujo RC; Heppenstall PA; Stucky CL; Silva JA; Walther T; Oliveira SM; Pesquero JL; Paiva ACM; Calixto JB; Lewin GR; Bader M
Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors
Proceedings of the National Academy of Sciences of the United States of America 97: 8140-8145 (2000-07-05)
Price MP; Lewin GR; McIlwrath SL; Cheng C; Xie JH; Heppenstall PA; Stucky CL; Mannsfeldt AG; Brennan TJ; Drummond HA; Qiao J; Benson CJ; Tarr DE; Hrstka RF; Yang BL; Williamson RA; Welsh MJ
The mammalian sodium channel BNC1 is required for normal touch sensation
Nature 407 (6807): 1007-1011 (2000-10-26)
1999
Mannsfeldt AG; Carroll P; Stucky CL; Lewin GR
Stomatin, a MEC-2 like protein, is expressed by mammalian sensory neurons
Molecular and Cellular Neuroscience 13: 391-404 (1999-06-01)
Braun A; Lommatzsch M; Lewin GR; Virchow JC; Renz H
Neurotrophins: a link between airway inflammation and airway smooth muscle contractility in asthma?
International Archives of Allergy and Immunology 118: 163-165 (1999-02-01)
Belyantseva IA; Lewin GR
Stability and plasticity of primary afferent projections following nerve regeneration and central degeneration
European Journal of Neuroscience 11: 457-468 (1999-02-01)
Lommatzsch M; Braun A; Mannsfeldt A; Botchkarev VA; Botchkareva NV; Paus R; Fischer A; Lewin GR; Renz H
Abundant production of brain-derived neurotrophic factor by adult visceral epithelia - Implications for paracrine and target-derived neurotrophic functions
American Journal of Pathology 155: 1183-1193 (1999-10-01)
Botchkarev VA; Botchkareva NV; Welker P; Metz M; Lewin GR; Subramaniam A; Bulfone-Paus S; Hagen E; Braun A; Lommatzsch M; Renz H; Paus R
A new role for neurotrophins: involvement of brain-derived neurotrophic factor and neurotrophin-4 in hair cycle control
FASEB Journal 13: 395-410 (1999-02-01)
Braun A; Lommatzsch M; Mannsfeldt A; Neuhaus-Steinmetz U; Fischer A; Schnoy N; Lewin GR; Renz H
Cellular sources of enhanced brain-derived neurotrophic factor production in a mouse model of allergic inflammation
American Journal of Respiratory Cell and Molecular Biology 21: 537-546 (1999-10-01)
Stucky CL; Lewin GR
Isolectin B4-positive and -negative nociceptors are functionally distinct
Journal of Neuroscience 19 (15): 6497-6505 (1999-08-01)
1998
Carroll P; Lewin GR; Koltzenburg M; Toyka KV; Thoenen H
A role for BDNF in mechanosensation
Nature Neuroscience 1: 42-46 (1998-05-01)
Botchkarev VA; Botchkareva NV; Lommatzsch M; Peters EMJ; Lewin GR; Subramaniam A; Braun A; Renz H; Paus R
BDNF overexpression induces differential increases among subsets of sympathetic innervation in murine back skin
European Journal of Neuroscience 10: 3276-3283 (1998-10-01)
Botchkarev VA; Welker P; Albers KM; Botchkareva NV; Metz M; Lewin GR; Bulfone-Paus S; Peters EM; Lindner G; Paus R
A new role for neurotrophin-3: Involvement in the regulation of hair follicle regression (catagen)
American Journal of Pathology 153: 785-799 (1998-09-01)
Botchkarev VA; Botchkareva NV; Albers KM; van der Veen C; Lewin GR; Paus R
Neurotrophin-3 involvement in the regulation of hair follicle morphogenesis
Journal of Investigative Dermatology 111: 279-285 (1998-01-01)
Minichiello L; Casagranda F; Tatche RS; Stucky CL; Postigo A; Lewin GR; Davies AM; Klein R
Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses
Neuron 21: 335-345 (1998-08-01)
Schober A; Wolf N; Huber K; Hertel R; Krieglstein K; Minichiello L; Kahane N; Widenfalk J; Kalcheim C; Olson L; Klein R; Lewin GR; Unsicker K
TrkB and neurotrophin-4 are important for development and maintenance of sympathetic preganglionic neurons innervating the adrenal medulla
Journal of Neuroscience 18 (18): 7272-7284 (1998-09-15)
1997
Riethmacher D; Sonnenberg-Riethmacher E; Brinkmann V; Yamaai T; Lewin GR; Birchmeier C
Severe neuropathies in mice with targeted mutations in the ErbB3 receptor
Nature 389 (6652): 725-730 (1997-10-16)
Koltzenburg M; Lewin GR
Receptive properties of embryonic chick sensory neurons innervating skin
Journal of Neurophysiology 78: 2560-2568 (1997-01-01)
Carter BD; Lewin GR
Neurotrophins live or let die: Does p75NTR decide
Neuron 18: 187-190 (1997-01-01)
Koltzenburg M; Lewin GR
Der Einfluss von Neutrophinen auf den Phaenotyp sensorischer Neurone
Neuroforum 3, Heft 1: 27-31 (1997-01-01)
Koltzenburg M; Stucky CL; Lewin GR
Receptive properties of mouse sensory neurons innervating hairy skin
Journal of Neurophysiology 78: 1841-1850 (1997-01-01)
1996
Airaksinen MS; Koltzenburg M; Lewin GR; Masu Y; Helbig C; Wolf E; Brem G; Toyka KV; Thoenen H; Meyer M
Specific subsets of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation
Neuron 16: 287-295 (1996-01-01)
Ockel M; Lewin GR; Barde YA
In vivo effects of neurotrophin-3 during sensory neurogenesis
Development 122 (1): 301-307 (1996-01)
Lewin GR; Barde YA
Physiology of the neurotrophins
Annual Review of Neuroscience 19: 289-317 (1996-03)
Ockel M; von Schack D; Schroepel A; Dechant G; Lewin GR; Barde YA
Roles of neurotrophin-3 during early development of the peripheral nervous system
Philosophical Transactions of the Royal Society of London Series B Biological Sciences 351: 383-387 (1996-01-01)
Lewin GR
Neurotrophins and the specification of neuronal phenotype
Philosophical Transactions of the Royal Society of London Series B Biological Sciences 351: 405-411 (1996-01-01)
Lewin GR; Mendell LM
Maintenance of modality-specific connections in the spinal cord after neonatal NGF deprivation
European Journal of Neuroscience 8: 1677-1684 (1996-01-01)
1995
Lewin GR
Neurotropic Factors and Pain
Seminars in the Neurosciences 7: 227-232 (1995-01-01)
1994
Pierce JP; Lewin GR
An ultrastructural size principle
Neuroscience 58 (3): 441-446 (1994-02-01)
Lewin GR; Mendell LM
Regulation of cutaneous C-fiber heat nociceptors by nerve growth factor in the developing rat
Journal of Neurophysiology 71 (3): 941-949 (1994-03-01)
Lewin GR; Rueff A; Mendell LM
Peripheral and central mechanisms of NGF-induced hyperalgesia
European Journal of Neuroscience 6 (12): 1903-1912 (1994-12-01)
Lewin GR; Mckintosh E; McMahon SB
NMDA receptors and activity-dependent tuning of the receptive fields of spinal cord neurons
Nature 369 (6480): 482-485 (1994-06-09)
1993
Davis BM; Lewin GR; Mendell LM; Jones ME; Albers KM
Altered expression of nerve growth factor in the skin of transgenic mice leads to changes in response to mechanical stimuli
Neuroscience 56 (4): 789-792 (1993-10-01)
Lewin GR; McMahon SB
Muscle afferents innervating skin form somatotopically appropriate connections in the adult rat dorsal horn
European Journal of Neuroscience 5: 1083-1092 (1993-08-01)
Lewin GR; Mendell LM
Nerve growth factor and nociception
Trends in Neurosciences 16: 353-359 (1993-09-01)
Lewin GR; Ritter AM; Mendell LM
Nerve growth factor-induced hyperalgesia in the neonatal and adult rat
Journal of Neuroscience 13 (5): 2136-2148 (1993-05)
Ritter AM; Lewin GR; Mendell LM
Regulation of myelinated nociceptor function by nerve growth factor in neonatal and adult rats
Brain Research Bulletin 30: 245-249 (1993-01-01)
1992
Lewin GR; Lisney SJW; Mendell LM
Neonatal Anit-Ngf treatment reduces the Adelta-and c-fibre evoked vasodilator responses in rat skin: evidence that nociceptor afferents mediate antidromic vasodilatation
European Journal of Neuroscience 4: 1213-1218 (1992-01-01)
Lewin GR; Ritter AM; Mendell LM
On the role of nerve growth factor in the development of myelinated nociceptors
Journal of Neuroscience 12 (5): 1896-1905 (1992-05)
Lewin GR; Winter J; McMahon SB
Regulation of afferent connectivity in the adult spinal-cord by nerve growth factor
European Journal of Neuroscience 4: 700-707 (1992-01-01)