Publications
2012
Guo W; Schafer S; Greaser ML; Radke MH; Liss M; Govindarajan T; Maatz H; Schulz H; Li S; Parrish AM; Dauksaite V; Vakeel P; Klaassen S; Gerull B; Thierfelder L; Regitz-Zagrosek V; Hacker TA; Saupe KW; Dec GW; Ellinor PT; Macrae CA; Spallek B; Fischer R; Perrot A; Ozcelik C; Saar K; Hubner N; Gotthardt M
RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing
Nature Medicine : (2012-04-01)
2011
da Silva Lopes K; Pietas A; Radke MH; Gotthardt M
Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres
Journal of Cell Biology 193 (4): 785-798 (2011-05-16)
Schreier B; Doehler M; Rabe S; Schneider B; Schwerdt G; Ruhs S; Sibilia M; Gotthardt M; Gekle M; Grossmann C
Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1
Arteriosclerosis Thrombosis and Vascular Biology 31 (7): 1643-1652 (2011-07)
2009
Shi Y; Chen C; Lisewski U; Wrackmeyer U; Radke M; Westermann D; Sauter M; Tschoepe C; Poller W; Klingel K; Gotthardt M
Cardiac deletion of the coxsackievirus-adenovirus receptor abolishes coxsackievirus b3 infection and prevents myocarditis in vivo
Journal of the American College of Cardiology 53 (14): 1219-1226 (2009-04-07)
Aziz EF; Ottosson N; Bonhommeau S; Bergmann N; Eberhardt W; Chergui M
Probing the electronic structure of the hemoglobin active center in physiological solutions
Physical Review Letters 102 (6): 068103 (2009-02-13)
Granzier HL; Radke MH; Peng J; Westermann D; Nelson OL; Rost K; King NM; Yu Q; Tschoepe C; McNabb M; Larson DF; Labeit S; Gotthardt M
Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction
Circulation Research 105 (6): 557-564 (2009-09-11)
2008
Lisewski U; Shi Y; Wrackmeyer U; Fischer R; Chen C; Schirdewan A; Juettner R; Rathjen F; Poller W; Radke MH; Gotthardt M
The tight junction protein CAR regulates cardiac conduction and cell-cell communication
Journal of Experimental Medicine 205 (10): 2369-2379 (2008-09-29)
2007
Peng J; Raddatz K; Molkentin JD; Wu Y; Labeit S; Granzier H; Gotthardt M
Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region
Circulation 115 (6): 743-751 (2007-02-13)
Radke MH; Peng J; Wu Y; McNabb M; Nelson OL; Granzier H; Gotthardt M
Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy
Proceedings of the National Academy of Sciences of the United States of America 104 (9): 3444-3449 (2007-02-27)
Jansen P; Giehl K; Nyengaard JR; Teng K; Lioubinski O; Sjoegaard SS; Breiderhoff T; Gotthardt M; Lin F; Eilers A; Petersen CM; Lewin GR; Hempstead BL; Willnow TE; Nykjaer A
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury
Nature Neuroscience 10 (11): 1449-1457 (2007-11)
2006
Weinert S; Bergmann N; Luo X; Erdmann B; Gotthardt M
M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere
Journal of Cell Biology 173 (4): 559-570 (2006-05-22)
2005
Andersen OM; Reiche J; Schmidt V; Gotthardt M; Spoelgen R; Behlke J; von Arnim CAF; Breiderhoff T; Jansen P; Wu X; Bales KR; Cappai R; Masters CL; Gliemann J; Mufson EJ; Hyman BT; Paul SM; Nykjaer A; Willnow TE
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein
Proceedings of the National Academy of Sciences of the United States of America 102: 13461-13466 (2005-09-07)
2003
Boucher P; Gotthardt M; Li WP; Anderson RG; Herz J
LRP: role in vascular wall integrity and protection from atherosclerosis
Science 300: 329-332 (2003-04-11)
2002
Holtwick R; Gotthardt M; Skryabin B; Steinmetz M; Potthast R; Zetsche B; Hammer RE; Herz J; Kuhn M
Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure
Proceedings of the National Academy of Sciences of the United States of America 99: 7142-7147 (2002-05-14)
2001
Bang ML; Centner T; Fornoff F; Geach AJ; Gotthardt M; McNabb M; Witt CC; Labeit D; Gregorio CC; Granzier H; Labeit S
The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system
Circulation Research 89: 1065-1072 (2001-11-23)
2000
Schmitz C; Gotthardt M; Hinderlich S; Leheste JR; Gross V; Vorum H; Christensen EI; Luft FC; Takahashi S; Willnow TE
Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor
Journal of Biological Chemistry 275: 15357-15362 (2000-05-19)
Gotthardt M; Trommsdorff M; Nevitt MF; Shelton J; Richardson JA; Stockinger W; Nimpf J; Herz J
Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction
Journal of Biological Chemistry 275 (33): 25616-25624 (2000-08-18)
Stockinger W; Brandes C; Fasching D; Hermann M; Gotthardt M; Herz J; Schneider WJ; Nimpf J
The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2
Journal of Biological Chemistry 275 (33): 25625-25632 (2000-08-18)
1999
Trommsdorff M; Gotthardt M; Hiesberger T; Shelton J; Stockinger W; Nimpf J; Hammer RE; Richardson JA; Herz J
Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2
Cell 97 (6): 689-701 (1999-06-11)
1998
Rohlmann A; Gotthardt M; Hammer RE; Herz J
Inducible inactivation of hepatic LRP gene by Cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants
Journal of Clinical Investigation 101 (3): 689-695 (1998-02-01)