Publications
2012
Seja P; Schonewille M; Spitzmaul G; Badura A; Klein I; Rudhard Y; Wisden W; Huebner CA; De Zeeuw CI; Jentsch TJ
Raising cytosolic Cl(-) in cerebellar granule cells affects their excitability and vestibulo-ocular learning
EMBO Journal 31 (5): 1217-1230 (2012-01-17)
Jeworutzki E; Lopez-Hernandez T; Capdevila-Nortes X; Sirisi S; Bengtsson L; Montolio M; Zifarelli G; Arnedo T; Mueller CS; Schulte U; Nunes V; Martinez A; Jentsch TJ; Gasull X; Pusch M; Estevez R
GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl(-) channel auxiliary subunit
Neuron 73 (5): 951-961 (2012-03-08)
2011
Billig GM; Pal B; Fidzinski P; Jentsch TJ
Ca(2+)-activated Cl(-) currents are dispensable for olfaction
Nature Neuroscience 14 (6): 763-769 (2011-06)
Leisle L; Ludwig CF; Wagner FA; Jentsch TJ; Stauber T
ClC-7 is a slowly voltage-gated 2Cl(-)/1H(+)-exchanger and requires Ostm1 for transport activity
EMBO Journal 30 (11): 2140-2152 (2011-06-01)
Heidenreich M; Lechner SG; Vardanyan V; Wetzel C; Cremers CW; De Leenheer EM; Aranguez G; Moreno-Pelayo MA; Jentsch TJ; Lewin GR
KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man
Nature Neuroscience 15 (1): 138-145 (2011-11-20)
2010
Rickheit G; Wartosch L; Schaffer S; Stobrawa S; Novarino G; Weinert S; Jentsch TJ
Role of CLC-5 in renal endocytosis is unique among CLC exchangers and does not require py-motif-dependent ubiquitylation
Journal of Biological Chemistry 285 (23): 17595-17603 (2010-06-04)
Novarino G; Weinert S; Rickheit G; Jentsch TJ
Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis
Science 328 (5984): 1398-1401 (2010-06-11)
Tzingounis AV; Heidenreich M; Kharkovets T; Spitzmaul G; Jensen HS; Nicoll RA; Jentsch TJ
The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus
Proceedings of the National Academy of Sciences of the United States of America 107 (22): 10232-10237 (2010-06-01)
Steinberg BE; Huynh KK; Brodovitch A; Jabs S; Stauber T; Jentsch TJ; Grinstein S
A cation counterflux supports lysosomal acidification
Journal of Cell Biology 189 (7): 1171-1186 (2010-06-28)
Weinert S; Jabs S; Supanchart C; Schweizer M; Gimber N; Richter M; Rademann J; Stauber T; Kornak U; Jentsch TJ
Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation
Science 328 (5984): 1401-1403 (2010-06-11)
Jentsch TJ; Maritzen T; Keating DJ; Zdebik AA; Thevenod F
ClC-3-A granular anion transporter involved in insulin secretion?
Cell Metabolism 12 (4): 307-308 (2010-10-06)
Neagoe I; Stauber T; Fidzinski P; Bergsdorf EY; Jentsch TJ
The late endosomal CLC-6 mediates proton/chloride countertransport in heterologous plasma membrane expression
Journal of Biological Chemistry 285 (28): 21689-21697 (2010-07-09)
Stauber T; Jentsch TJ
Sorting motifs of the endosomal/lysosomal CLC chloride transporters
Journal of Biological Chemistry 285 (45): 34537-34548 (2010-11-05)
Preston P; Wartosch L; Guenzel D; Fromm M; Kongsuphol P; Ousingsawat J; Kunzelmann K; Barhanin J; Warth R; Jentsch TJ
Disruption of the K+ channel beta-subunit KCNE3 reveals an important role in intestinal and tracheal Cl- transport
Journal of Biological Chemistry 285 (10): 7165-7175 (2010-03-05)
2009
Wartosch L; Fuhrmann JC; Schweizer M; Stauber T; Jentsch TJ
Lysosomal degradation of endocytosed proteins depends on the chloride transport protein ClC-7
FASEB Journal 23 (12): 4056-4068 (2009-12)
Zdebik AA; Wangemann P; Jentsch TJ
Potassium ion movement in the inner ear: insights from genetic disease and mouse models
Physiology 24 (5): 307-316 (2009-10)
Planells-Cases R; Jentsch TJ
Chloride channelopathies
Biochimica et Biophysica Acta - Molecular Basis of Disease 1792 (3): 173-189 (2009-03)
Pfeffer CK; Stein V; Keating DJ; Maier H; Rinke I; Rudhard Y; Hentschke M; Rune GM; Jentsch TJ; Huebner CA
NKCC1-dependent GABAergic excitation drives synaptic network maturation during early hippocampal development
Journal of Neuroscience 29 (11): 3419-3430 (2009-03-18)
Plans V; Rickheit G; Jentsch TJ
Physiological roles of CLC Cl(-)/H (+) exchangers in renal proximal tubules
Pfluegers Archiv European Journal of Physiology 458 (1): 23-37 (2009-05)
Bergsdorf EY; Zdebik AA; Jentsch TJ
Residues important for nitrate/proton coupling in plant and mammalian CLC transporters
Journal of Biological Chemistry 284 (17): 11184-11193 (2009-04-24)
2008
Jentsch TJ
CLC chloride channels and transporters: from genes to protein structure, pathology and physiology
Critical Reviews in Biochemistry and Molecular Biology 43 (1): 3-36 (2008-01)
Zdebik AA; Zifarelli G; Bergsdorf EY; Soliani P; Scheel O; Jentsch TJ; Pusch M
Determinants of anion-proton coupling in mammalian endosomal CLC proteins
Journal of Biological Chemistry 283 (7): 4219-4227 (2008-02-15)
Maritzen T; Keating DJ; Neagoe I; Zdebik AA; Jentsch TJ
Role of the vesicular chloride transporter ClC-3 in neuroendocrine tissue
Journal of Neuroscience 28 (42): 10587-10598 (2008-10-15)
Rickheit G; Maier H; Strenzke N; Andreescu CE; De Zeeuw CI; Muenscher A; Zdebik AA; Jentsch TJ
Endocochlear potential depends on Cl(-) channels: mechanism underlying deafness in Bartter syndrome IV
EMBO Journal 27 (21): 2907-2917 (2008-11-05)
2007
Jentsch TJ
Chloride and the endosomal/lysosomal pathway: emerging roles of CLC chloride transporters
Journal of Physiology 578 (Pt 3): 633-640 (2007-02-01)
Rust MB; Alper SL; Rudhard Y; Shmukler BE; Vicente R; Brugnara C; Trudel M; Jentsch TJ; Huebner CA
Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice
Journal of Clinical Investigation 117 (6): 1708-1717 (2007-06)
Blanz J; Schweizer M; Auberson M; Maier H; Muenscher A; Huebner CA; Jentsch TJ
Leukoencephalopathy upon disruption of the chloride channel ClC-2
Journal of Neuroscience 27 (24): 6581-9 (2007-06-13)
2006
Hentschke M; Wiemann M; Hentschke S; Kurth I; Hermans-Borgmeyer I; Seidenbecher T; Jentsch TJ; Gal A; Huebner CA
Mice with a targeted disruption of the Cl-/HCO3- exchanger AE3 display a reduced seizure threshold
Molecular and Cellular Biology 26 (1): 182-191 (2006-01)
Lange PF; Wartosch L; Jentsch TJ; Fuhrmann JC
ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function
Nature 440 (7081): 220-223 (2006-03-09)
Poet M; Kornak U; Schweizer M; Zdebik AA; Scheel O; Hoelter S; Wurst W; Schmitt A; Fuhrmann JC; Planells-Cases R; Mole SE; Huebner CA; Jentsch TJ
Lysosomal storage disease upon disruption of the neuronal chloride transport protein ClC-6
Proceedings of the National Academy of Sciences of the United States of America 103: 13854-13859 (2006-09-12)
Schwake M; Athanasiadu D; Beimgraben C; Blanz J; Beck C; Jentsch TJ; Saftig P; Friedrich T
Structural determinants of M-type KCNQ (Kv7) K+ channel assembly
Journal of Neuroscience 26 (14): 3757-3766 (2006-04-05)
Kharkovets T; Dedek K; Maier H; Schweizer M; Khimich D; Nouvian R; Vardanyan V; Leuwer R; Moser T; Jentsch TJ
Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness
EMBO Journal 25 (3): 642-652 (2006-02-08)
Rust MB; Faulhaber J; Budack MK; Pfeffer P; Maritzen T; Didie M; Beck FX; Boettger T; Schubert R; Ehmke H; Jentsch TJ; Huebner CA
Neurogenic mechanisms contribute to hypertension in mice with disruption of the K-Cl cotransporter KCC3
Circulation Research 98 (4): 549-556 (2006-03-03)
2005
Schenzer A; Friedrich T; Pusch M; Saftig P; Jentsch TJ; Groetzinger J; Schwake M
Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine
Journal of Neuroscience 25 (20): 5051-5060 (2005-05-18)
Jentsch TJ; Poet M; Fuhrmann JC; Zdebik AA
Physiological functions of CLC Cl- channels gleaned from human genetic disease and mouse models
Annual Review of Physiology 67: 779-807 (2005-03)
Jentsch TJ; Neagoe I; Scheel O
CLC chloride channels and transporters
Current Opinion in Neurobiology 15 (3): 319-325 (2005-06)
Jentsch TJ; Maritzen T; Zdebik AA
Chloride channel diseases resulting from impaired transepithelial transport or vesicular function
Journal of Clinical Investigation 115 (8): 2039-2046 (2005-08)
Scheel O; Zdebik AA; Lourdel S; Jentsch TJ
Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins
Nature 436 (7049): 424-427 (2005-07-21)
Kasper D; Planells-Cases R; Fuhrmann JC; Scheel O; Zeitz O; Ruether K; Schmitt A; Poet M; Steinfeld R; Schweizer M; Kornak U; Jentsch TJ
Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration
EMBO Journal 24 (5): 1079-1091 (2005-03-09)
2004
Zdebik AA; Cuffe JE; Bertog M; Korbmacher C; Jentsch TJ
Additional disruption of the ClC-2 Cl(-) channel does not exacerbate the cystic fibrosis phenotype of cystic fibrosis transmembrane conductance regulator mouse models
Journal of Biological Chemistry 279 (21): 22276-22283 (2004-05-21)
Jentsch TJ; Huebner CA; Fuhrmann JC
Ion channels: function unravelled by dysfunction
Nature Cell Biology 6 (11): 1039-1047 (2004-11)
Huber SM; Duranton C; Henke G; Van De Sand C; Heussler V; Shumilina E; Sandu CD; Tanneur V; Brand V; Kasinathan RS; Lang KS; Kremsner PG; Huebner CA; Rust MB; Dedek K; Jentsch TJ; Lang F
Plasmodium induces swelling-activated ClC-2 anion channels in the host erythrocyte
Journal of Biological Chemistry 279 (40): 41444-41452 (2004-10-01)
2003
Boettger T; Rust MB; Maier H; Seidenbecher T; Schweizer M; Keating DJ; Faulhaber J; Ehmke H; Pfeffer C; Scheel O; Lemcke B; Horst J; Leuwer R; Pape HC; Voelkl H; Huebner CA; Jentsch TJ
Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold
EMBO Journal 22 (20): 5422-5434 (2003-10-15)
Schwake M; Jentsch TJ; Friedrich T
A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly
EMBO Reports 4 (1): 76-81 (2003-01)
Estevez R; Schroeder BC; Accardi A; Jentsch TJ; Pusch M
Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1
Neuron 38 (1): 47-59 (2003-04-10)
2002
Jentsch TJ; Stein V; Weinreich F; Zdebik AA
Molecular structure and physiological function of chloride channels
Physiological Reviews 82 (2): 503-568 (2002-04)
Jentsch TJ
Chloride channels are different
Nature 415 (6869): 276-277 (2002-01-17)
Boettger T; Huebner CA; Maier H; Rust MB; Beck FX; Jentsch TJ
Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4
Nature 416 (6883): 874-878 (2002-04-25)
Estevez R; Jentsch TJ
CLC chloride channels: correlating structure with function
Current Opinion in Structural Biology 12 (4): 531-539 (2002-08)
Huebner CA; Jentsch TJ
Ion channel diseases
Human Molecular Genetics 11 (20): 2435-2445 (2002-10-01)
2001
Huebner CA; Stein V; Hermans-Borgmeyer I; Meyer T; Ballanyi K; Jentsch TJ
Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition
Neuron 30 (2): 515-524 (2001-03)
Weinreich F; Jentsch TJ
Pores formed by single subunits in mixed dimers of different CLC chloride channels
Journal of Biological Chemistry 276 (4): 2347-2353 (2001-01-26)
Dedek K; Kunath B; Kananura C; Reuner U; Jentsch TJ; Steinlein OK
Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channel
Proceedings of the National Academy of Sciences of the United States of America 98 (21): 12272-12277 (2001-10-09)
Estevez R; Boettger T; Stein V; Birkenhaeger R; Otto E; Hildebrandt F; Jentsch TJ
Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion
Nature 414 (6863): 558-561 (2001-11-29)
Kornak U; Kasper D; Boesl MR; Kaiser E; Schweizer M; Schulz A; Friedrich W; Delling G; Jentsch TJ
Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man
Cell 104 (2): 205-215 (2001-01-26)
Schwake M; Friedrich T; Jentsch TJ
An internalization signal in ClC-5, an endosomal Cl-channel mutated in dent's disease
Journal of Biological Chemistry 276 (15): 12049-12054 (2001-04-13)
Boesl MR; Stein V; Huebner CA; Zdebik AA; Jordt SE; Mukhopadhyay AK; Davidoff MS; Holstein AF; Jentsch TJ
Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption
EMBO Journal 20 (6): 1289-1299 (2001-03-15)
Betz RC; Schoser BGH; Kasper D; Ricker K; Ramirez A; Stein V; Torbergsen T; Lee YA; Nothen MM; Wienker TF; Malin JP; Propping P; Reis A; Mortier W; Jentsch TJ; Vorgerd M; Kubisch C
Mutations in CAV3 cause mechanical hyperirritability of skeletal muscle in rippling muscle disease
Nature Genetics 28 (3): 218-219 (2001-07)
Stobrawa SM; Breiderhoff T; Takamori S; Engel D; Schweizer M; Zdebik AA; Boesl MR; Ruether K; Jahn H; Draguhn A; Jahn R; Jentsch TJ
Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus
Neuron 29 (1): 185-196 (2001-01)
2000
Weinreich F; Jentsch TJ
Neurological diseases caused by ion-channel mutations
Current Opinion in Neurobiology 10 (3): 409-415 (2000-06)
Waldegger S; Jentsch TJ
Functional and structural analysis of ClC-K chloride channels involved in renal disease
Journal of Biological Chemistry 275 (32): 24527-24533 (2000-08-11)
Schroeder BC; Hechenberger M; Weinreich F; Kubisch C; Jentsch TJ
KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents
Journal of Biological Chemistry 275 (31): 24089-24095 (2000-08-04)
Yamamoto K; Cox JP; Friedrich T; Christie PT; Bald M; Houtman PN; Lapsley MJ; Patzer L; Tsimaratos M; Van'T Hoff WG; Yamaoka K; Jentsch TJ; Thakker RV
Characterization of renal chloride channel (CLCN5) mutations in Dent's disease
Journal of the American Society of Nephrology 11 (8): 1460-1468 (2000-08)
Schwake M; Pusch M; Kharkovets T; Jentsch TJ
Surface expression and single channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy
Journal of Biological Chemistry 275 (18): 13343-13348 (2000-05-05)
Kornak U; Schulz A; Friedrich W; Uhlhaas S; Kremens B; Voit T; Hasan C; Bode U; Jentsch TJ; Kubisch C
Mutations in the a3 subunit of the vacuolar H(+)-ATPase cause infantile malignant osteopetrosis
Human Molecular Genetics 9 (13): 2059-2063 (2000-08-12)
Kharkovets T; Hardelin JP; Safieddine S; Schweizer M; El-Amraoui A; Petit C; Jentsch TJ
KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway
Proceedings of the National Academy of Sciences of the United States of America 97 (8): 4333-4338 (2000-04-11)
Schroeder BC; Waldegger S; Fehr S; Bleich M; Warth R; Greger R; Jentsch TJ
A constitutively open potassium channel formed by KCNQ1 and KCNE3
Nature 403 (6766): 196-199 (2000-01-13)
Piwon N; Guenther W; Schwake M; Boesl MR; Jentsch TJ
ClC-5 Cl- -channel disruption impairs endocytosis in a mouse model for Dent's disease
Nature 408 (6810): 369-373 (2000-11-16)
1999
Friedrich T; Breiderhoff T; Jentsch TJ
Mutational analysis demonstrates that ClC-4 and ClC-5 directly mediate plasma membrane currents
Journal of Biological Chemistry 274 (2): 896-902 (1999-01-08)
Schriever AM; Friedrich T; Pusch M; Jentsch TJ
CLC chloride channels in Caenorhabditis elegans
Journal of Biological Chemistry 274 (48): 34238-34244 (1999-11-26)
Kubisch C; Schroeder BC; Friedrich T; Luetjohann B; El-Amraoui A; Marlin S; Petit C; Jentsch TJ
KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness
Cell 96 (3): 437-446 (1999-02-05)
1998
Guenther W; Luechow A; Cluzeaud F; Vandewalle A; Jentsch TJ
ClC-5, the chloride channel mutated in Dent's disease, colocalizes with the proton pump in endocytotically active kidney cells
Proceedings of the National Academy of Sciences of the United States of America 95 (14): 8075-8080 (1998-07-07)
Kubisch C; Schmidt-Rose T; Fontaine B; Bretag AH; Jentsch TJ
ClC-1 chloride channel mutations in myotonia congenita: variable penetrance of mutations shifting the voltage dependence
Human Molecular Genetics 7 (11): 1753-1760 (1998-10)
Rychkov GY; Pusch M; Roberts ML; Jentsch TJ; Bretag AH
Permeation and block of the skeletal muscle chloride channel, ClC-1, by foreign anions
Journal of General Physiology 111 (5): 653-665 (1998-05)
Schwappach B; Stobrawa S; Hechenberger M; Steinmeyer K; Jentsch TJ
Golgi localization and functionally important domains in the NH2 and COOH terminus of the yeast CLC putative chloride channel Gef1p
Journal of Biological Chemistry 273 (24): 15110-15108 (1998-06-12)
Schroeder BC; Kubisch C; Stein V; Jentsch TJ
Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy
Nature 396 (6712): 687-690 (1998-12-17)
Biervert C; Schroeder BC; Kubisch C; Berkovic SF; Propping P; Jentsch TJ; Steinlein OK
A potassium channel mutation in neonatal human epilepsy
Science 279 (5349): 403-406 (1998-01-16)
1997
Schmidt-Rose T; Jentsch TJ
Transmembrane topology of a CLC chloride channel
Proceedings of the National Academy of Sciences of the United States of America 94 (14): 7633-7638 (1997-07-08)
Lloyd SE; Pearce SH; Guenther W; Kawaguchi H; Igarashi T; Jentsch TJ; Thakker RV
Idiopathic low molecular weight proteinuria associated with hypercalciuric nephrocalcinosis in Japanese children is due to mutations of the renal chloride channel (CLCN5)
Journal of Clinical Investigation 99 (5): 967-974 (1997-03-01)
Jordt SE; Jentsch TJ
Molecular dissection of gating in the ClC-2 chloride channel
EMBO Journal 16 (7): 1582-1592 (1997-04-01)
Lloyd SE; Gunther W; Pearce SH; Thomson A; Bianchi ML; Bosio M; Craig IW; Fisher SE; Scheinman SJ; Wrong O; Jentsch TJ; Thakker RV
Characterisation of renal chloride channel, CLCN5, mutations in hypercalciuric nephrolithiasis (kidney stones) disorders
Human Molecular Genetics 6 (8): 1233-1239 (1997-08)
Wollnik B; Schroeder BC; Kubisch C; Esperer HD; Wieacker P; Jentsch TJ
Pathophysiological mechanisms of dominant and recessive KVLQT1 K+ channel mutations found in inherited cardiac arrhythmias
Human Molecular Genetics 6 (11): 1943-1949 (1997-10)
Schmidt-Rose T; Jentsch TJ
Reconstitution of functional voltage-gated chloride channels from complementary fragments of CLC-1
Journal of Biological Chemistry 272 (33): 20515-20521 (1997-08-15)
1996
Staley K; Smith R; Schaack J; Wilcox C; Jentsch TJ
Alteration of GABAA receptor function following gene transfer of the CLC-2 chloride channel
Neuron 17 (3): 543-551 (1996-09)
Ludewig U; Pusch M; Jentsch TJ
Two physically distinct pores in the dimeric ClC-0 chloride channel
Nature 383 (6598): 340-343 (1996-09-26)
Lloyd SE; Pearce SH; Fisher SE; Steinmeyer K; Schwappach B; Scheinman SJ; Harding B; Bolino A; Devoto M; Goodyer P; Rigden SP; Wrong O; Jentsch TJ; Craig IW; Thakker RV
A common molecular basis for three inherited kidney stone diseases
Nature 379 (6564): 445-449 (1996-02-01)
Lorenz C; Pusch M; Jentsch TJ
Heteromultimeric CLC chloride channels with novel properties
Proceedings of the National Academy of Sciences of the United States of America 93 (23): 13362-13366 (1996-11-12)
Hechenberger M; Schwappach B; Fischer WN; Frommer WB; Jentsch TJ; Steinmeyer K
A family of putative chloride channels from Arabidopsis and functional complementation of a yeast strain with a CLC gene disruption
Journal of Biological Chemistry 271 (52): 33632-33638 (1996-12-27)
1995
Pusch M; Ludewig U; Rehfeldt A; Jentsch TJ
Gating of the voltage-dependent chloride channel CIC-0 by the permeant anion
Nature 373 (6514): 527-531 (1995-02-09)
Meyer-Kleine C; Steinmeyer K; Ricker K; Jentsch TJ; Koch MC
Spectrum of mutations in the major human skeletal muscle chloride channel gene (CLCN1) leading to myotonia
American Journal of Human Genetics 57 (6): 1325-1334 (1995-12)
Pusch M; Steinmeyer K; Koch MC; Jentsch TJ
Mutations in dominant human myotonia congenita drastically alter the voltage dependence of the CIC-1 chloride channel
Neuron 15 (6): 1455-1463 (1995-12)
Steinmeyer K; Schwappach B; Bens M; Vandewalle A; Jentsch TJ
Cloning and functional expression of rat CLC-5, a chloride channel related to kidney disease
Journal of Biological Chemistry 270 (52): 31172-31177 (1995-12-29)
1994
Jentsch TJ
Trinity of cation channels
Nature 367 (6462): 412-413 (1994-02-03)
Steinmeyer K; Lorenz C; Pusch M; Koch MC; Jentsch TJ
Multimeric structure of ClC-1 chloride channel revealed by mutations in dominant myotonia congenita (Thomsen)
EMBO Journal 13 (4): 737-743 (1994-02-15)
Klocke R; Steinmeyer K; Jentsch TJ; Jockusch H
Role of innervation, excitability, and myogenic factors in the expression of the muscular chloride channel ClC-1. A study on normal and myotonic muscle
Journal of Biological Chemistry 269 (44): 27635-27639 (1994-11-04)
Pusch M; Jentsch TJ
Molecular physiology of voltage-gated chloride channels
Physiological Reviews 74 (4): 813-827 (1994-10)
Gronemeier M; Condie A; Prosser J; Steinmeyer K; Jentsch TJ; Jockusch H
Nonsense and missense mutations in the muscular chloride channel gene Clc-1 of myotonic mice
Journal of Biological Chemistry 269 (8): 5963-5967 (1994-02-25)
Kieferle S; Fong P; Bens M; Vandewalle A; Jentsch TJ
Two highly homologous members of the ClC chloride channel family in both rat and human kidney
Proceedings of the National Academy of Sciences of the United States of America 91 (15): 6943-6947 (1994-07-19)
1992
Gruender S; Thiemann A; Pusch M; Jentsch TJ
Regions involved in the opening of CIC-2 chloride channel by voltage and cell volume
Nature 360 (6406): 759-762 (1992-12-24)
Koch MC; Steinmeyer K; Lorenz C; Ricker K; Wolf F; Otto M; Zoll B; Lehmann-Horn F; Grzeschik KH; Jentsch TJ
The skeletal muscle chloride channel in dominant and recessive human myotonia
Science 257 (5071): 797-800 (1992-08-07)
Thiemann A; Gruender S; Pusch M; Jentsch TJ
A chloride channel widely expressed in epithelial and non-epithelial cells
Nature 356 (6364): 57-60 (1992-03-05)
1991
Steinmeyer K; Ortland C; Jentsch TJ
Primary structure and functional expression of a developmentally regulated skeletal muscle chloride channel
Nature 354 (6351): 301-304 (1991-11-28)
Steinmeyer K; Klocke R; Ortland C; Gronemeier M; Jockusch H; Gruender S; Jentsch TJ
Inactivation of muscle chloride channel by transposon insertion in myotonic mice
Nature 354 (6351): 304-308 (1991-11-28)
Bauer CK; Steinmeyer K; Schwarz JR; Jentsch TJ
Completely functional double-barreled chloride channel expressed from a single Torpedo cDNA
Proceedings of the National Academy of Sciences of the United States of America 88 (24): 11052-11056 (1991-12-15)
1990
Jentsch TJ; Steinmeyer K; Schwarz G
Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes
Nature 348 (6301): 510-514 (1990-12-06)