Selected Publications
2012
Bieschke J; Herbst M; Wiglenda T; Friedrich RP; Boeddrich A; Schiele F; Kleckers D; Lopez Del Amo JM; Gruening BA; Wang Q; Schmidt MR; Lurz R; Anwyl R; Schnoegl S; Faendrich M; Frank RF; Reif B; Guenther S; Walsh DM; Wanker EE
Small-molecule conversion of toxic oligomers to nontoxic {beta}-sheet-rich amyloid fibrils
Nature Chemical Biology 8 (1): 93-101 (2012-01)
Sommer AP; Bieschke J; Friedrich RP; Zhu D; Wanker EE; Fecht HJ; Mereles D; Hunstein W
670 nm laser light and EGCG complementarily reduce amyloid-{beta} aggregates in human neuroblastoma cells: basis for treatment of Alzheimer's disease?
Photomedicine and Laser Surgery 30 (1): 54-60 (2012-01)
Schaefer MH; Wanker EE; Andrade-Navarro MA
Evolution and function of CAG/polyglutamine repeats in protein-protein interaction networks
Nucleic Acids Research : (2012-01-28)
Lopez Del Amo JM; Fink U; Dasari M; Grelle G; Wanker EE; Bieschke J; Reif B
Structural properties of EGCG-induced, nontoxic Alzheimer's disease A{beta} oligomers
Journal of Molecular Biology : (2012-01-28)
2011
Lilie H; Baer D; Kettner K; Weininger U; Balbach J; Naumann M; Mueller EC; Otto A; Gast K; Golbik R; Kriegel T
Yeast hexokinase isoenzyme ScHxk2: stability of a two-domain protein with discontinuous domains
Protein Engineering Design and Selection 24 (1-2): 79-87 (2011-01)
Vinayagam A; Stelzl U; Foulle R; Plassmann S; Zenkner M; Timm J; Assmus HE; Andrade-Navarro MA; Wanker EE
A directed protein interaction network for investigating intracellular signal transduction
Science Signaling 4 (189): rs8 (2011-09-06)
Grelle G; Otto A; Lorenz M; Frank RF; Wanker EE; Bieschke J
Black tea theaflavins inhibit formation of toxic amyloid-beta and alpha-synuclein fibrils
Biochemistry 50 (49): 10624-10636 (2011-12-13)
Imre L; Balogh I; Kappelmayer J; Szabo M; Melegh B; Wanker E; Szabo G
Detection of mutations by flow cytometric melting point analysis of PCR products
Cytometry Part A 79A (9): 720-726 (2011-09)
Kunde SA; Musante L; Grimme A; Fischer U; Mueller E; Wanker EE; Kalscheuer VM
The X-chromosome linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules
Human Molecular Genetics 20 (24): 4916-4931 (2011-12-15)
Dasari M; Espargaro A; Sabate R; Lopez Del Amo JM; Fink U; Grelle G; Bieschke J; Ventura S; Reif B
Bacterial inclusion bodies of Alzheimer's disease beta-amyloid peptides can be employed to study native-like aggregation intermediate states
Chembiochem : (2011-01-10)
Schierack P; Kleta S; Tedin K; Babila JT; Oswald S; Oelschlaeger TA; Hiemann R; Paetzold S; Wieler LH
E. coli Nissle 1917 Affects Salmonella Adhesion to Porcine Intestinal Epithelial Cells
PLoS ONE 6 (2): e14712 (2011-02-17)
Tamura T; Sone M; Iwatsubo T; Tagawa K; Wanker EE; Okazawa H
Ku70 alleviates neurodegeneration in drosophila models of Huntington's disease
PLoS ONE 6 (11): e27408 (2011-11-07)
von Eyss B; Maaskola J; Memczak S; Moellmann K; Schuetz A; Loddenkemper C; Tanh MD; Otto A; Muegge K; Heinemann U; Rajewsky N; Ziebold U
The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation
EMBO Journal : (2011-12-13)
Gilbert DF; Erdmann G; Zhang X; Fritzsche A; Demir K; Jaedicke A; Muehlenberg K; Wanker EE; Boutros M
A novel multiplex cell viability assay for high-throughput RNAi screening
PLoS ONE 6 (12): e28338 (2011-12-05)
Schierack P; Weinreich J; Ewers C; Tachu B; Nicholson B; Barth S
Hemolytic porcine intestinal Escherichia coli without virulence-associated genes typical of intestinal pathogenic E. coli
Applied and Environmental Microbiology 77 (23): 8451-8455 (2011-12)
2010
Kuettner EB; Kettner K; Keim A; Svergun DI; Volke D; Singer D; Hoffmann R; Mueller EC; Otto A; Kriegel TM; Straeter N
Crystal structure of hexokinase KlHxk1 of Kluyveromyces lactis: a molecular basis for understanding the control of yeast hexokinase functions via covalent modification and oligomerization
Journal of Biological Chemistry 285 (52): 41019-41033 (2010-12-24)
Vinayagam A; Stelzl U; Wanker EE
Repeated two-hybrid screening detects transient protein-protein interactions
Theoretical Chemistry Accounts 125 (3-6): 613-619 (2010-03)
Marras E; Travaglione A; Chaurasia G; Futschik M; Capobianco E
Inferring modules from human protein interactome classes
BMC Systems Biology 4: 102 (2010-07-23)
Porras P; McDonagh B; Pedrajas JR; Barcena JA; Padilla CA
Structure and function of yeast glutaredoxin 2 depend on postranslational processing and are related to subcellular distribution
Biochimica et Biophysica Acta - Proteins and Proteomics 1804 (4): 839-845 (2010-04)
Enokido Y; Tamura T; Ito H; Arumughan A; Komuro A; Shiwaku H; Sone M; Foulle R; Sawada H; Ishiguro H; Ono T; Murata M; Kanazawa I; Tomilin N; Tagawa K; Wanker EE; Okazawa H
Mutant huntingtin impairs Ku70-mediated DNA repair
Journal of Cell Biology 189 (3): 425-443 (2010-05-03)
Bieschke J
Gruener Tee - neue Einsichten fuer einen alten Wirkstoff [Green tea - new insights for an old drug]
Chemie in unserer Zeit 44 (4): 306-307 (2010-08)
Goehler H; Droege A; Lurz R; Schnoegl S; Chernoff YO; Wanker EE
Pathogenic polyglutamine tracts are potent inducers of spontaneous sup35 and rnq1 amyloidogenesis
PLoS ONE 5 (3): e9642 (2010-03-10)
Patzke C; Max KE; Behlke J; Schreiber J; Schmidt H; Dorner AA; Kroeger S; Henning M; Otto A; Heinemann U; Rathjen FG
The coxsackievirus-adenovirus receptor reveals complex homophilic and heterophilic interactions on neural cells
Journal of Neuroscience 30 (8): 2897-2910 (2010-02-24)
Bieschke J; Russ J; Friedrich RP; Ehrnhoefer DE; Wobst H; Neugebauer K; Wanker EE
EGCG remodels mature {alpha}-synuclein and amyloid-{beta} fibrils and reduces cellular toxicity
Proceedings of the National Academy of Sciences of the United States of America 107 (17): 7710-7715 (2010-04-27)
2009
Chirasani SR; Markovic DS; Synowitz M; Eichler SA; Wisniewski P; Kaminska B; Otto A; Wanker E; Schaefer M; Chiarugi P; Meier JC; Kettenmann H; Glass R
Transferrin-receptor-mediated iron accumulation controls proliferation and glutamate release in glioma cells
Journal of Molecular Medicine 87 (2): 153-167 (2009-02)
Venkatesan K; Rual JF; Vazquez A; Stelzl U; Lemmens I; Hirozane-Kishikawa T; Hao T; Zenkner M; Xin X; Goh KI; Yildirim MA; Simonis N; Heinzmann K; Gebreab F; Sahalie JM; Cevik S; Simon C; de Smet AS; Dann E; Smolyar A; Vinayagam A; Yu H; Szeto D; Borick H; Dricot A; Klitgord N; Murray RR; Lin C; Lalowski M; Timm J; Rau K; Boone C; Braun P; Cusick ME; Roth FP; Hill DE; Tavernier J; Wanker EE; Barabasi AL; Vidal M
An empirical framework for binary interactome mapping
Nature Methods 6 (1): 83-90 (2009-01)
Tamura T; Sone M; Yamashita M; Wanker EE; Okazawa H
Glial cell lineage expression of mutant ataxin-1 and huntingtin induces developmental and late-onset neuronal pathologies in drosophila models
PLoS ONE 4 (1): e4262 (2009)
Palidwor GA; Shcherbinin S; Huska MR; Rasko T; Stelzl U; Arumughan A; Foulle R; Porras P; Sanchez-Pulido L; Wanker EE; Andrade-Navarro MA
Detection of alpha-rod protein repeats using a neural network and application to huntingtin
PLoS Computational Biology 5 (3): e1000304 (2009-03)
Chaurasia G; Malhotra S; Russ J; Schnoegl S; Haenig C; Wanker EE; Futschik ME
UniHI 4: new tools for query, analysis and visualization of the human protein-protein interactome
Nucleic Acids Research 37 (Database Issue): D657-D660 (2009-01)
Figueroa A; Kotani H; Toda Y; Mazan-Mamczarz K; Mueller EC; Otto A; Disch L; Norman M; Ramdasi R; Keshtgar M; Gorospe M; Fujita Y
Novel roles of Hakai in cell proliferation and oncogenesis
Molecular Biology of the Cell 20 (15): 3533-3542 (2009-08)
Kegel KB; Schewkunow V; Sapp E; Masso N; Wanker EE; Difiglia M; Goldmann WH
Polyglutamine expansion in huntingtin increases its insertion into lipid bilayers
Biochemical and Biophysical Research Communications 387 (3): 472-475 (2009-09-25)
2008
Ehrnhoefer DE; Bieschke J; Boeddrich A; Herbst M; Masino L; Lurz R; Engemann S; Pastore A; Wanker EE
EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
Nature Structural & Molecular Biology 15 (6): 558-566 (2008-06)
Inagaki R; Tagawa K; Qi ML; Enokido Y; Ito H; Tamura T; Shimizu S; Oyanagi K; Arai N; Kanazawa I; Wanker EE; Okazawa H
Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease
European Journal of Neuroscience 28 (1): 30-40 (2008-07)
Schueler H; Peti W
Structure-function analysis of the filamentous actin binding domain of the neuronal scaffolding protein spinophilin
FEBS Journal 275 (1): 59-68 (2008-01)
Aranda-Orgilles B; Trockenbacher A; Winter J; Aigner J; Koehler A; Jastrzebska E; Stahl J; Mueller EC; Otto A; Wanker EE; Schneider R; Schweiger S
The Opitz syndrome gene product MID1 assembles a microtubule-associated ribonucleoprotein complex
Human Genetics 123 (2): 163-176 (2008-03)
Stoeckl M; Fischer P; Wanker E; Herrmann A
Alpha-synuclein selectively binds to anionic phospholipids embedded in liquid-disordered domains
Journal of Molecular Biology 375 (5): 1394-1404 (2008-02-01)
Zolghadr K; Mortusewicz O; Rothbauer U; Kleinhans R; Goehler H; Wanker EE; Cardoso MC; Leonhardt H
A fluorescent two-hybrid (F2H) assay for direct visualization of protein interactions in living cells
Molecular and Cellular Proteomics 7 (11): 2279-2287 (2008-11)
Minnerop M; Herbst M; Fimmers R; Matz B; Klockgether T; Wuellner U
Bell's palsy: combined treatment of famciclovir and prednisone is superior to prednisone alone
Journal of Neurology 255 (11): 1726-1730 (2008-11)
Klinke T; Rump A; Poenisch R; Schellenberger W; Mueller EC; Otto A; Klimm W; Kriegel TM
Identification and characterization of CaApe2 – a neutral arginine/alanine/leucine-specific metallo-aminopeptidase from Candida albicans
FEMS Yeast Research 8 (6): 858-869 (2008-09)
Mereles D; Wanker EE; Katus HA
Therapy effects of green tea in a patient with systemic light-chain amyloidosis
Clinical Research in Cardiology 97 (5): 341-344 (2008-05)
2007
Chaurasia G; Iqbal Y; Haenig C; Herzel H; Wanker EE; Futschik ME
Flexible web-based integration of distributed large-scale human protein interaction maps
Journal of Integrative Bioinformatics 4 (1): 51 (2007-02-26)
Qi ML; Tagawa K; Enokido Y; Yoshimura N; Wada YI; Watase K; Ishiura SI; Kanazawa I; Botas J; Saitoe M; Wanker EE; Okazawa H
Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases
Nature Cell Biology 9: 402-414 (2007-04-01)
Herbst M; Wanker EE
Small molecule inducers of heat-shock response reduce polyQ-mediated huntingtin aggregation. A possible therapeutic strategy
Neurodegenerative Diseases 4 (2-3): 254-260 (2007)
Huebbers CU; Clemen CS; Kesper K; Boeddrich A; Hofmann A; Kaemaeraeinen O; Tolksdorf K; Stumpf M; Reichelt J; Roth U; Krause S; Watts G; Kimonis V; Wattjes MP; Reimann J; Thal DR; Biermann K; Evert BO; Lochmueller H; Wanker EE; Schoser BG; Noegel AA; Schroeder R
Pathological consequences of VCP mutations on human striated muscle
Brain 130: 381-393 (2007-02-01)
Stenmark P; Kursula P; Flodin S; Graeslund S; Landry R; Nordlund P; Schueler H
Crystal structure of human inosine triphosphatase: Substrate binding and implication of the itpa deficiency mutation p32T
Journal of Biological Chemistry 282: 3182-3187 (2007-02-02)
Behlke J; Ristau O; Mueller EC; Hannemann F; Bernhardt R
Self-association of adrenodoxin studied by using analytical ultracentrifugation
Biophysical Chemistry 125 (1): 159-165 (2007-01)
Tagawa K; Marubuchi S; Qi ML; Enokido Y; Tamura T; Inagaki R; Murata M; Kanazawa I; Wanker EE; Okazawa H
The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes
Journal of Neuroscience 27 (4): 868-880 (2007-01-24)
Chaurasia G; Iqbal Y; Haenig C; Herzel H; Wanker EE; Futschik ME
UniHI: an entry gate to the human protein interactome
Nucleic Acids Research 35 (Database Issue): D590-D594 (2007-01)
Futschik ME; Chaurasia G; Herzel H
Comparison of human protein-protein interaction maps
Bioinformatics 23(5): 605-611 (2007-03-01)
2006
Horn SC; Lalowski M; Goehler H; Droege A; Wanker EE; Stelzl U
Huntingtin interacts with the receptor sorting family protein GASP2
Journal of Neural Transmission 113 (8): 1081-1090 (2006-08)
Hockly E; Tse J; Barker AL; Moolman DL; Beunard JL; Revington AP; Holt K; Sunshine S; Moffitt H; Sathasivam K; Woodman B; Wanker EE; Lowden PA; Bates GP
Evaluation of the benzothiazole aggregation inhibitors riluzole and PGL-135 as therapeutics for Huntington's disease
Neurobiology of Diseases 21: 228-236 (2006-01-01)
Jeub M; Herbst M; Spauschus A; Fleischer H; Klockgether T; Wuellner U; Evert BO
Potassium channel dysfunction and depolarized resting membrane potential in a cell model of SCA3
Exp Neurol 201: 182-192 (2006-09-01)
Herbst M; Wanker EE
Therapeutic approaches to polyglutamine diseases: combating protein misfolding and aggregation
Current Pharmaceutical Design 12 (20): 2543-2555 (2006-07-01)
Mueller EC
Mass spectrometry: ESI
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2 : 1020-1022 (2006-07-05)
Droege A
Recombinant protein production in mammalian cell culture
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2 : 1616-1620 (2006-07-05)
Ehrnhoefer DE; Duennwald M; Markovic P; Wacker JL; Engemann S; Roark M; Legleiter J; Marsh JL; Thompson LM; Lindquist S; Muchowski PJ; Wanker EE
Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models
Human Molecular Genetics 15 (18): 2743-2751 (2006-09-15)
Hufton AL; Vinayagam A; Suhai S; Baker JC
Genomic analysis of Xenopus organizer function
BMC Developmental Biology 6: 27 (2006-06-06)
Schueler H; Matuschewski K
Regulation of apicomplexan microfilament dynamics by a minimal set of actin-binding proteins
Traffic 7 (11): 1433-1439 (2006-11)
Kursula P; Flodin S; Ehn M; Hammarstroem M; Schueler H; Nordlund P; Stenmark P
Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy
Acta Crystallographica Section F 62 (7): 613-617 (2006-07)
Grelle G; Kostka S; Otto A; Kersten B; Genser KF; Mueller EC; Waelter S; Boeddrich A; Stelzl U; Haenig C; Volkmer-Engert R; Landgraf C; Alberti S; Hoehfeld J; Stroedicke M; Wanker EE
Identification of VCP/p97, CHIP and amphiphysin II interaction partners using membrane-based human proteome arrays
Molecular & Cellular Proteomics : MCP 5: 234-244 (2006-02-01)
Chaurasia G; Herzel H; Wanker EE; Futschik ME
Systematic functional assessment of human protein-protein interaction maps
Genome Inform 17: 36-45 (2006)
Gizatullina ZZ; Lindenberg KS; Harjes P; Chen Y; Kosinski CM; Landwehrmeyer BG; Ludolph AC; Striggow F; Zierz S; Gellerich FN
Low stability of huntington muscle mitochondria against Ca2+ in R6/2 mice
Annals of Neurology 59: 407-411 (2006-01-25)
Suopanki J; Goetz C; Lutsch G; Schiller J; Harjes P; Herrmann A; Wanker EE
Interaction of huntingtin fragments with brain membranes - clues to early dysfunction in Huntington's disease
Journal of Neurochemistry 96 (3): 870-884 (2006-02)
Stelzl U; Wanker EE
Protein-Wechselwirkungsnetzwerke: Aufklaerung der Funktion von Proteinen
Biologie in unserer Zeit 36 (1): 12-13 (2006-01-16)
Wolski WE; Farrow M; Emde AK; Lehrach H; Lalowski M; Reinert K
Analytical model of peptide mass cluster centres with applications
Proteome Science 4: 18 (2006-09-23)
Kessels MM; Dong J; Leibig W; Westermann P; Qualmann B
Complexes of syndapin II with dynamin II promote vesicle formation at the trans-Golgi network
Journal of Cell Science 119: 1504-1516 (2006-04-15)
Stelzl U; Wanker EE
The value of high quality protein-protein interaction networks for systems biology
Current Opinion in Chemical Biology 10 (6): 551-558 (2006-12)
Zemojtel T; Froehlich A; Palmieri MC; Kolanczyk M; Mikula I; Wyrwicz LS; Wanker EE; Mundlos S; Vingron M; Martasek P; Durner J
Plant nitric oxide synthase: a never-ending story?
Trends Plant Sci 11: 524-525 (2006-11-01)
Hoshino M; Qi ML; Yoshimura N; Miyashita T; Tagawa K; Wada YI; Enokido Y; Marubuchi S; Harjes P; Arai N; Oyanagi K; Blandino G; Sudol M; Rich T; Kanazawa I; Wanker EE; Saitoe M; Okazawa H
Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73
Journal of Cell Biology 172 (4): 589-604 (2006-02-13)
Schueler H; Karlsson R; Schutt CE; Lindberg U
The connection between actin ATPase and polymerization
Advances in Molecular and Cell Biology 37: 49-66 (2006-01-01)
Boeddrich A; Gaumer S; Haacke A; Tzvetkov N; Albrecht M; Evert BO; Mueller EC; Lurz R; Breuer P; Schugardt N; Plassmann S; Xu K; Warrick JM; Suopanki J; Wuellner U; Frank R; Hartl UF; Bonini NM; Wanker EE
An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis
EMBO Journal 25 (7): 1547-1558 (2006-04-05)
Schueler H; Matuschewski K
Plasmodium motility: actin not actin' like actin
Trends in Parasitology 22 (4): 146-147 (2006-04)
Weidemann W; Stelzl U; Lisewski U; Bork K; Wanker EE; Hinderlich S; Horstkorte R
The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis
FEBS Letters 580 (28): 6649-6654 (2006-12-11)
2005
Ralser M; Nonhoff U; Albrecht M; Lengauer T; Wanker EE; Lehrach H; Krobitsch S
Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways
Human Molecular Genetics 14: 2893-2909 (2005-08-22)
Ralser M; Goehler H; Wanker EE; Lehrach H; Krobitsch S
Generation of a yeast two-hybrid strain suitable for competitive protein binding analysis
Biotechniques 39: 165-168 (2005-08-01)
Wolski WE; Lalowski M; Martus P; Herwig R; Giavalisco P; Gobom J; Sickmann A; Lehrach H; Reinert K
Transformation and other factors of the peptide mass spectrometry pairwise peak-list comparison process
BMC Bioinformatics 6: 285 (2005-11-30)
Stelzl U; Worm U; Lalowski M; Haenig C; Brembeck FH; Goehler H; Stroedicke M; Zenkner M; Schoenherr A; Koeppen S; Timm J; Mintzlaff S; Abraham C; Bock N; Kietzmann S; Goedde A; Toksoez E; Droege A; Krobitsch S; Korn B; Birchmeier W; Lehrach H; Wanker EE
A human protein-protein interaction network: a resource for annotating the proteome
Cell 122 (6): 957-968 (2005-09-23)
Wolski WE; Lalowski M; Jungblut P; Reinert K
Calibration of mass spectrometric peptide mass fingerprint data without specific external or internal calibrants
BMC Bioinformatics 6: 203 (2005-08-15)
Mirgorodskaya E; Wanker EE; Otto A; Lehrach H; Gobom J
Method for qualitative comparisons of protein mixtures based on enzyme-catalyzed stable-isotope incorporation
Journal of Proteome Research 4: 2109-2116 (2005-11-01)
Zhang X; Smith DL; Meriin AB; Engemann S; Russel DE; Roark M; Washington SL; Maxwell MM; Marsh JL; Thompson LM; Wanker EE; Young AB; Housman DE; Bates GP; Sherman MY; Kazantsev AG
A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo
Proceedings of the National Academy of Sciences of the United States of America 102: 892-897 (2005-01-18)
Simoes I; Mueller EC; Otto A; Bur D; Cheung AY; Faro C; Pires E
Molecular analysis of the interaction between cardosin A and phospholipase Dalpha
FEBS Journal 272: 5786-5798 (2005-11-01)
Herbst M; Wattjes MP; Urbach H; Inhetvin-Hutter C; Becker D; Kjockgether T; Hartmann A
Cerebral embolism from left atrial myxoma leading to cerebral and retinal aneurysms: A case report
American Journal of Neuroradiology 26: 666-669 (2005-01-01)
Karapetian RN; Evstafieva AG; Abaeva IS; Chichkova NV; Filonov GS; Rubtsov YP; Sukhacheva EA; Melnikov SV; Schneider U; Wanker EE; Vartapetian AB
Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes
Molecular and Cellular Biology 25: 1089-1099 (2005-02-01)
Kersten B; Wanker EE; Hoheisel JD; Angenendt P
Multiplex approaches in protein microarray technology
Expert Reviews of Proteomics 2: 499-510 (2005-08-01)
Mologni L; Moza M; Lalowski MM; Carpen O
Characterization of mouse myotilin and its promoter
Biochemical and Biophysical Research Communications 329: 1001-1009 (2005-01-01)
Yu M; Schreek S; Cerni C; Schamberger C; Lesniewicz K; Poreba E; Vervoorts J; Walsemann G; Groetzinger J; Kremmer E; Mehraein Y; Mertsching J; Kraft R; Austen M; Luscher-Firzlaff J; Luescher B
PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation
Oncogene 24: 1982-1993 (2005-01-01)
Bardischewsky F; Quentmeier A; Rother D; Hellwig P; Kostka S; Friedrich CG
Sulfur dehydrogenase of Paracoccus pantotrophus: The heme-2 domain of the molybdoprotein cytochrome c complex is dispensable for catalytic activity
Biochemistry 44: 7024-7034 (2005-01-01)
Daechsel JC; Luecking CB; Deeg S; Schultz E; Lalowski M; Casademunt E; Corti O; Hampe C; Patenge N; Vaupel K; Yamamoto A; Dichgans M; Brice A; Wanker EE; Kahle PJ; Gasser T
Parkin interacts with the proteasome subunit alpha4
FEBS Letters 579: 3913-3919 (2005-07-18)
Feilner T; Hultschig C; Lee J; Meyer S; Immink RG; Koenig A; Possling A; Seitz H; Beveridge A; Scheel D; Cahill DJ; Lehrach H; Kreutzberger J; Kersten B
High-throughput identification of potential Arabidopsis MAP kinases substrates
Molecular & Cellular Proteomics : MCP 4: 1558-1568 (2005-07-11)
2004
Albrecht AN; Kornak U; Boeddrich A; Suering K; Robinson PN; Stiege AC; Lurz R; Stricker S; Wanker EE; Mundlos S
A molecular pathogenesis for transcription factor associated poly-alanine tract expansions
Human Molecular Genetics 13: 2351-2359 (2004-01-01)
Blume A; Weidemann W; Stelzl U; Wanker EE; Lucka L; Donner P; Reutter W; Horstkorte R; Hinderlich S
Domain specific characteristics of the bifunctional key enzyme of sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
Biochemical Journal 384: 599-607 (2004-08-26)
Wehrl W; Meyer TF; Jungblut PR; Mueller EC; Szczepek AJ
Action and reaction: Chlamydophila pneumoniae proteome alteration in a persistent infection induced by iron deficiency
Proteomics 4: 2969-2981 (2004-01-01)
Goehler H; Lalowski M; Stelzl U; Waelter S; Stroedicke M; Worm U; Droege A; Lindenberg KS; Knoblich M; Haenig C; Herbst M; Suopanki J; Scherzinger E; Abraham C; Bauer B; Hasenbank R; Fritzsche A; Ludewig AH; Buessow K; Coleman SH; Gutekunst CA; Landwehrmeyer BG; Lehrach H; Wanker EE
A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease [Erratum in: Mol Cell. vol 19, pg 287, 2005]
Molecular Cell 15: 853-865 (2004-09-24)
Gruenberg K; Mueller EC; Otto A; Reszka R; Linder D; Kube M; Reinhardt R; Schueler D
Biochemical and proteomic analysis of the magnetosome membrane in Magnetospitillum gryphiswaldense
Applied and Environmental Microbiology 70: 1040-1050 (2004-01-01)
Okkels LM; Mueller EC; Schmid M; Rosenkrands I; Kaufmann SHE; Andersen P; Jungblut PR
CFP10 discriminates between nonacetylated and acetylated ESAT-6 of Mycobacterium tuberculosis by differential interaction
Proteomics 4: 2954-2960 (2004-01-01)
Kilian K; Dernedde J; Mueller EC; Bahr I; Tauber R
The interaction of protein kinase C isozymes alpha, iota, and theta with the cytoplasmic domain of L-selectin is modulated by phosphorylation of the receptor
Journal of Biological Chemistry 279: 34472-34480 (2004-01-01)
Schiffler B; Bureik M; Reinle W; Mueller EC; Hannemann F; Bernhardt R
The adrenodoxin-like ferredoxin of Schizosaccharomyces pombe mitochondria
Journal of Inorganic Biochemistry 98: 1229-1237 (2004-01-01)
Schnoegl S; Wanker EE
Grossfahndung nach Hemmstoffen : Huntington-Forschung in Deutschland
Spektrum der Wissenschaft 1: 64-65 (2004-01-01)
Qin ZH; Wang Y; Sapp E; Cuiffo B; Wanker EE; Hayden MR; Kegel KB; Aronin N; DiFiglia M
Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction
Journal of Neuroscience 7 (1): 269-281 (2004-01-07)
Tagawa K; Hoshino M; Okuda T; Ueda H; Hayashi H; Engemann S; Okado H; Ichikawa M; Wanker EE; Okazawa H
Distinct aggregation and cell death patterns among different types of primary neurons induced by mutant huntingtin protein
Journal of Neurochemistry 89: 974-987 (2004-01-01)
Sajidan A; Farouk A; Greiner R; Jungblut P; Mueller EC; Borriss R
Molecular and physiological characterisation of a 3-phytase from soil bacterium Klebsiella sp. ASR1
Applied Microbiology and Biotechnology 65: 110-118 (2004-01-01)
2003
Stelzl U; Zengel JM; Tovbina M; Walker M; Nierhaus KH; Lindahl L; Patel DJ
RNA-structural mimicry in Escherichia coli ribosomal protein L4-dependent regulation of the S10 operon
Journal of Biological Chemistry 278: 28237-28245 (2003-01-01)
Magro G; Perissinotto D; Schiappacassi M; Goletz S; Otto A; Mueller EC; Bisceglia M; Brown G; Ellis T; Grasso S; Colombatti A; Perris R
Proteomic and postproteomic characterization of keratan sulfate-glycanated isoforms of thyroglobulin and transferrin uniquely elaborated by papillary thyroid carcinomas
American Journal of Pathology 163: 183-196 (2003-01-01)
Odintsova TI; Mueller EC; Ivanov AV; Egorov TA; Bienert R; Vladimirov SN; Kostka S; Otto A; Wittmann-Liebold B; Karpova GG
Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing
Journal of Protein Chemistry 22 (3): 249-258 (2003-01-01)
Mattow J; Schaible UE; Schmidt F; Hagens K; Siejak R; Brestrich G; Haeselbarth G; Mueller EC; Jungblut PR; Kaufmanni SHE
Comparative proteome analysis of culture supernatant proteins from virulent Mycobacterium tuberculosis H37Rv and attenuated M-bovis BCG Copenhagen
Electrophoresis 24: 3405-3420 (2003-01-01)
Bollig F; Winzen R; Gaestel M; Kostka S; Resch K; Holtmann H
Affinity purification of ARE-binding proteins identifies polyA-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization
Biochemical and Biophysical Research Communications 301 (3): 665-670 (2003-02-14)
Baer D; Golbik R; Huebner G; Lilie H; Mueller EC; Naumann M; Otto A; Reuter R; Breunig KD; Kriegel TM
The unique hexokinase of Kluyveromyces lactis - Molecular and functional characterization and evaluation of a role in glucose signaling
Journal of Biological Chemistry 278: 39280-39286 (2003-01-01)
Harjes P; Wanker EE
The hunt for huntingtin function: interaction partners tell many different stories
Trends in Biochemical Sciences 28 (8): 425-433 (2003-08)
Busch A; Engemann S; Lurz R; Okazawa H; Lehrach H; Wanker EE
Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin - A potential mechanism for loss of huntingtin function in Huntington's disease
Journal of Biological Chemistry 278: 41452-41461 (2003-01-01)
Laurine E; Gregoire C; Faendrich M; Engemann S; Marchal S; Thion L; Mohr M; Monsarrat B; Michel B; Dobson CM; Wanker EE; Erard M; Verdier JM
Lithostathine quadruple-helical filaments form proteinase K-resistant deposits in Creutzfeldt-Jakob disease
Journal of Biological Chemistry 278: 51770-51778 (2003-01-01)
Klein H; Mueller S; Loeschner B; Toenjes RR; Braun G; Mueller EC; Otto A; Montag T
Cloning, sequencing and recombinant expression of the open reading frame encoding a novel member of the Sarcocystis muris (Apicomplexa) microneme lectin family
Parasitology Research 90: 84-86 (2003-01-01)
Ross CA; Poirier MA; Wanker EE; Amzel M
Polyglutamine fibrillogenesis: The pathway unfolds
Proceedings of the National Academy of Sciences of the United States of America 100: 1-3 (2003-01-01)
Andersen OM; Yeung CH; Vorum H; Wellner M; Andreassen TK; Erdmann B; Mueller EC; Herz J; Otto A; Cooper TG; Willnow TE
Essential role of the apolipoprotein E receptor-2 in sperm development
Journal of Biological Chemistry 278: 23989-23995 (2003-01-01)
Czupalla C; Culo M; Mueller EC; Brock C; Reusch HP; Spicher K; Krause E; Nuernberg B
Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma
Journal of Biological Chemistry 278: 11536-11545 (2003-01-01)
Hoshino M; Tagawa K; Okuda T; Murata M; Oyanagi K; Arai N; Mizutani T; Kanazawa I; Wanker EE; Okazawa H
Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin protein
Journal of Neurochemistry 87: 257-267 (2003-01-01)
Gonzalez LJ; Castellanos-Serra L; Badock V; Diaz M; Moro A; Perea S; Santos A; Paz-Lago D; Otto A; Mueller EC; Kostka S; Wittmann-Liebold B; Padron G
Identification of nuclear proteins of small cell lung cancer cell line H82: An improved procedure for the analysis of silver-stained proteins
Electrophoresis 24: 237-252 (2003-01-01)
2002
Lebeau A; Zeindl-Eberhart E; Mueller EC; Mueller-Hoecker J; Jungblut PR; Emmerich B; Loehrs U
Generalized crystal-storing histiocytosis associated with monoclonal gammopathy: molecular analysis of a disorder with rapid clinical course and review of the literature
Blood 100: 1817-1827 (2002-01-01)
Srisomsap C; Subhasitanont P; Otto A; Mueller EC; Punyarit P; Wittmann-Liebold B; Svasti J
Detection of cathepsin B up-regulation in neoplastic thyroid tissues by proteomic analysis
Proteomics 2: 706-712 (2002-01-01)
Heiser V; Engemann S; Broecker W; Dunkel I; Boeddrich A; Waelter S; Nordhoff E; Lurz R; Schugardt N; Rautenberg S; Herhaus C; Barnickel G; Boettcher H; Lehrach H; Wanker EE
Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay
Proceedings of the National Academy of Sciences of the United States of America 99, Suppl. 4: 16400-16406 (2002-08-28)
Li PF; Li JC; Mueller EC; Otto A; Dietz R; von Harsdorf R
Phosphorylation by protein kinase CK2: A signaling switch for the caspase-inhibiting protein ARC
Molecular Cell 10: 247-258 (2002-01-01)
Perutz MF; Pope BJ; Owen D; Wanker EE; Scherzinger E
Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine-rich domains of Sup35 and of the amyloid beta-peptide of amyloid plaques
Proceedings of the National Academy of Sciences of the United States of America 99 (8): 5596-5600 (2002-01-01)
Albrecht AN; Schwabe GC; Stricker S; Boeddrich A; Wanker EE; Mundlos S
The synpolydactyly homolog (spdh) mutation in the mouse -- a defect in patterning and growth of limb cartilage elements
Mechanisms of Development 112: 53-67 (2002-03-01)
Muecke M; Grelle G; Behlke J; Kraft R; Krueger DH; Reuter M
EcoRII: a restriction enzyme evolving recombination functions
EMBO Journal 21: 5262-5268 (2002-01-01)
Moencke-Buchner E; Reich S; Muecke M; Reuter M; Messer W; Wanker EE; Krueger DH
NAR Methods Online: Counting CAG repeats in the Huntington's disease gene by restriction endonuclease EcoP15I cleavage
Nucleic Acids Research 30 (16): e83 (2002-08-15)
Wanker EE
Hip1 and Hippi participate in a novel cell death-signaling pathway
Developmental Cell 2: 126-128 (2002-02-01)
Muecke M; Pingoud V; Grelle G; Kraft R; Krueger DH; Reuter M
Asymmetric photocross-linking pattern of restriction endonuclease EcoRII to the DNA recognition sequence
Journal of Biological Chemistry 277 (16): 14288-14293 (2002-01-01)
Peterbauer CK; Litscher D; Kubicek CP
The Trichoderma atroviride seb1 (stress response element binding) gene encodes an AGGGG-binding protein which is involved in the response to high osmolarity stress
Molecular Genetics and Genomics 268: 223-231 (2002-01-01)
Contzen J; Kostka S; Kraft R; Jung C
Intermolecular electron transfer in cytochrome P450cam covalently bound with Tris(2,2'-bipyridyl)ruthenium(II): structural changes detected by FTIR spectroscopy
Journal of Inorganic Biochemistry 91: 607-617 (2002-01-01)
Moencke-Buchner E; Reich S; Muecke M; Reuter M; Messer W; Wanker EE; Krueger DH
Counting CAG repeats in the Huntington's disease gene by restriction endonuclease EcoP15I cleavage -art. no 83
Nucleic Acids Research 30 (16): e83 (2002-08-15)
Calado A; Treichel N; Mueller EC; Otto A; Kutay U
Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA
EMBO Journal 21: 6216-6224 (2002-01-01)
2001
Mueller EC; Lapko A; Otto A; Mueller JJ; Ruckpaul K; Heinemann U
Covalently crosslinked complexes of bovine adrenodoxin with adrenodoxin reductase and cytochrome P450scc. Mass spectrometry and Edman degradation of complexes of the steroidogenic hydroxylase system.
European Journal of Biochemistry 268: 1837-1843 (2001-01-01)
Badock V; Steinhusen U; Bommert K; Wittmann-Liebold B; Otto A
Apoptosis-induced cleavage of keratin 15 and keratin 17 in a human breast epithelial cell line
Cell Death and Differentiation 8: 308-315 (2001-03-01)
Waelter S; Boeddrich A; Lurz R; Scherzinger E; Lueder G; Lehrach H; Wanker EE
Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation
Molecular Biology of the Cell 12 (5): 1393-1407 (2001-05)
Backert S; Mueller EC; Jungblut PR; Meyer TF
Tyrosine phosphorylation patterns and size modification of the Helicobacter pyori CagA protein after translocation into gastric epithelial cells
Proteomics 1: 608-617 (2001-01-01)
Waelter S; Scherzinger E; Hasenbank R; Nordhoff E; Lurz R; Goehler H; Gauss C; Sathasivam K; Bates GP; Lehrach H; Wanker EE
The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis
Human Molecular Genetics 10: 1807-1817 (2001-08-15)
Koritschoner NP; Madruga J; Knespel S; Blendinger G; Anzinger B; Otto A; Zenke M; Bartunek P
The nuclear orphan receptor TR4 promotes proliferation of myeloid progenitor cells
Cell Growth and Differentiation 12: 563-572 (2001-01-01)
Roemer I; Vogel T; Otto A; Fichtner I; Klose J
Analysis of mouse beta-haptoglobin chain by lectin affinoblotting detection
Electrophoresis 22: 3038-3042 (2001-01-01)
Badock V; Steinhusen U; Bommert K; Otto A
Prefractionation of protein samples for proteome analysis using reversed-phase high-performance liquid chromatography
Electrophoresis 22: 2856-2864 (2001-01-01)
Andreeva AY; Krause E; Mueller EC; Blasig IE; Utepbergenov DI
Protein kinase C regulates the phosphorylation and cellular localization of occludin
Journal of Biological Chemistry 276: 38480-38486 (2001-01-01)
Souto-Carneiro MM; Burkhardt H; Mueller EC; Hermann R; Otto A; Kraetsch HG; Sack U; Koenig A; Heinegard D; Muller-Hermelink HK; Krenn V
Human monoclonal rheumatoid synovial B Lymphocyte hybridoma with a new disease-related specificity for cartilage oligomeric matrix protein
Journal of Immunology 166: 4202-4208 (2001-01-01)
Sathasivam K; Woodman B; Mahal A; Bertaux F; Wanker EE; Shima DT; Bates GP
Centrosome disorganization in fibroblast cultures derived from R6/2 Huntington's disease (HD) transgenic mice and HD patients
Human Molecular Genetics 10: 2425-2435 (2001-10-01)
Mueller JJ; Mueller EC; Montag T; Zyto N; Loeschner B; Klein H; Heineman U; Otto A
Characterization and crystallization of a novel Sarcocystis muris lectin, SML-2
Acta Crystallographica Section D 57: 1042-1045 (2001-01-01)
Urlaub H; Raker VA; Kostka S; Luehrmann R
Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure
EMBO Journal 20: 187-196 (2001-01-01)
Wieske M; Benndorf R; Behlke J; Doelling R; Grelle G; Bielka H; Lutsch G
Defined sequence segments of the small heat shock proteins HSP25 and alphaB-crystallin inhibit actin polymerization
European Journal of Biochemistry 268: 2083-2090 (2001-01-01)
Sittler A; Lurz R; Lueder G; Priller J; Lehrach H; Hayer-Hartl MK; Hartl FU; Wanker EE
Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease
Human Molecular Genetics 10: 1307-1315 (2001-06-01)
Muehlhaeusser P; Mueller EC; Otto A; Kutay U
Multiple pathways contribute to nuclear import of core histones
EMBO Reports 2: 690-696 (2001-01-01)
Zimdahl H; Goesele C; Luetjens G; Gruetzner F; Kreitler T; Voss K; Wanker EE; Knoblauch M
Assignment of the huntingtin (Hdh) gene, the huntingtin associated protein (Hap1) gene, and the huntingtin interacting protein (Hip1) gene to rat chromosomes 14, 10, and 12 by radiation hybrid mapping and fluorescent in situ hybridization
Cytogenetics and Cell Genetics 94: 101-104 (2001-01-01)
Tomasi V; Laktionov PP; Bryksin AV; Volod'ko NV; Griffoni C; Rykova EV; Spisni E; Kraft R; Vlassov VV
Glyceraldehyde-3-phosphate dehydrogenase is responsible for intranuclear localization of some oligonucleotides
Nucleosides Nucleotides & Nucleic Acids 20: 863-867 (2001-01-01)
Jungblut PR; Mueller EC; Mattow J; Kaufmann SHE
Proteomics reveals open reading frames in Mycobacterium tuberculosis H37Rv not predicted by genomics
Infection and Immunity 69: 5905-5907 (2001-01-01)
Mattow J; Jungblut PR; Mueller EC; Kaufmann SHE
Identification of acidic, low molecular mass proteins of Mycobacterium tuberculosis strain H37Rv by matrix-assisted laser desorption/ionization and electrospray ionization mass spectrometry
Proteomics 1: 494-507 (2001-01-01)
Mingot JM; Kostka S; Kraft R; Hartmann E; Goerlich D
Importin 13: a novel mediator of nuclear import and export
EMBO Journal 20: 3685-3694 (2001-01-01)
Mauch DH; Naegler K; Schumacher S; Goeritz C; Mueller EC; Otto A; Pfrieger FW
CNS synaptogenesis promoted by glia-derived cholesterol
Science 294 (5545): 1354-1357 (2001-11-09)
Bech-Otschir D; Kraft R; Huang XH; Henklein P; Kapelari B; Pollmann C; Dubiel W
COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system
EMBO Journal 20: 1630-1639 (2001-01-01)
Harms G; Kraft R; Grelle G; Volz B; Dernedde J; Tauber R
Identification of nucleolin as a new L-selectin ligand
Biochemical Journal 360: 531-538 (2001-01-01)
Smith DL; Portier R; Woodman B; Hockly E; Mahal A; Klunk WE; Li XJ; Wanker EE; Murray KD; Bates GP
Inhibition of polyglutamine aggregation in R6/2 HD brain slices-complex dose-response profiles
Neurobiology of Diseases 8: 1017-1026 (2001-12-01)
Griffoni C; Laktionov PP; Rykova EY; Spisni E; Riccio M; Santi S; Bryksin A; Volodko N; Kraft R; Vlassov V; Tomasi V
The Rossmann fold of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a nuclear docking site for antisense oligonucleotides containing a TAAAT motif
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1530: 32-46 (2001-01-01)
Golbik R; Naumann M; Otto A; Mueller EC; Behlke J; Reuter R; Kriegel TM
Regulation of phosphotransferase activity of hexokinase 2 from Saccharomyces cerevisiae by modification at serine-14
Biochemistry 40: 1083-1090 (2001-01-01)
Mattow J; Jungblut PR; Schaible UE; Mollenkopf HJ; Lamer S; Zimny-Arndt U; Hagens K; Mueller EC; Kaufmann SHE
Identification of proteins from Mycobacterium tuberculosis missing in attenuated Mycobacterium bovis BCG strains
Electrophoresis 22: 2936-2946 (2001-01-01)
2000
Friedrich CG; Quentmeier A; Bardischewsky F; Rother D; Kraft R; Kostka S; Prinz H
Novel genes coding for lithotrophic sulfur oxidation of Paracoccus pantotrophus GB17
Journal of Bacteriology 182: 4677-4687 (2000-09-01)
Kettritz R; Xu YX; Faass B; Klein JB; Mueller EC; Otto A; Busjahn A; Luft FC; Haller H
TNF-alpha-mediated neutrophil apoptosis involves Ly-GDI, a Rho GTPase regulator
Journal of Leukocyte Biology 68: 277-283 (2000-08-01)
Dong J; Radau B; Otto A; Mueller EC; Lindschau C; Westermann P
Profilin I attached to the Golgi is required for the formation of constitutive transport vesicles at the trans-Golgi network
Biochimica et Biophysica Acta - Molecular Cell Research 1497: 253-260 (2000-07-21)
Heiser V; Scherzinger E; Boeddrich A; Nordhoff E; Lurz R; Schugardt N; Lehrach H; Wanker EE
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy
Proceedings of the National Academy of Sciences of the United States of America 97 (12): 6739-6744 (2000-06-06)
Muchowski PJ; Schaffar G; Sittler A; Wanker EE; Hayer-Hartl MK; Hartl FU
Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils
Proceedings of the National Academy of Sciences of the United States of America 97 (14): 7841-7846 (2000-07-05)
Urlaub H; Hartmuth K; Kostka S; Grelle G; Luehrmann R
A general approach for identification of RNA-Protein cross-linking sites within native human spliceosomal small nuclear ribonucleoproteins (snRNPs) - Analysis of RNA-protein contacts in native U1 and U4/U6.U5 snRNPs
Journal of Biological Chemistry 275: 41458-41468 (2000-01-01)
Cohen H; Azriel A; Cohen T; Meraro D; Hashmueli S; Bech-Otschir D; Kraft R; Dubiel W; Levi BZ
Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15) - A possible link between interferon regulatory factor signaling and the COP9/signalosome
Journal of Biological Chemistry 275: 39081-39089 (2000-01-01)
Lipowsky G; Bischoff FR; Schwarzmaier P; Kraft R; Kostka S; Hartmann E; Kutay U; Goerlich D
Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes
EMBO Journal 19: 4362-4371 (2000-08-15)
Radau B; Otto A; Mueller EC; Westermann P
Protein kinase Calpha-dependent phosphorylation of golgi proteins
Electrophoresis 21: 2684-2687 (2000-07-01)
Schwarz K; van den Broek M; Kostka S; Kraft R; Soza A; Schmidtke G; Kloetzel PM; Groettrup M
Overexpression of the proteasome subunits LMP2, LMP7, and MECL-1, but not PA28 alpha/beta, enhances the presentation of an immunodominant lymphocytic choriomeningitis virus T cell epitope
Journal of Immunology 165: 768-778 (2000-07-15)
Quentmeier A; Kraft R; Kostka S; Klockenkaemper R; Friedrich CG
Characterization of a new type of sulfite dehydrogenase from Paracoccus pantotrophus GB17
Archives of Microbiology 173: 117-125 (2000-02-01)
Mueller EC; Wittmann-Liebold B; Otto A
Investigation of apoptosis-involved processes by mass spectrometric identification of the apoptosis-associated proteins in IgM-induced burkitt lymphoma cells
Mass Spectrometry in Biology and Medicine : 271-287 (2000-01-01)
Wanker EE
Protein aggregation and pathogenesis of Huntington's disease: mechanisms and correlations
Biological Chemistry 381: 937-942 (2000-09-01)
Essmann F; Wieder T; Otto A; Mueller EC; Doerken B; Daniel PT
GDP dissociation inhibitor D4-GDI (Rho-GDI 2), but not the homologous Rho-GDI 1, is cleaved by caspase-3 during drug-induced apoptosis
Biochemical Journal 346 Part 3: 777-783 (2000-03-15)
Stohwasser R; Giesebrecht J; Kraft R; Mueller EC; Haeusler KG; Kettenmann H; Hanisch UK; Kloetzel PM
Biochemical analysis of proteasomes from mouse microglia: Induction of immunoproteasomes by interferon-gamma and lipopolysaccharide
Glia 29: 355-365 (2000-02-15)
Wanker EE
Protein aggregation in Huntington's and Parkinson's disease: implications for therapy
Molecular Medicine Today 6: 387-391 (2000-10-01)
Meyer HA; Grau H; Kraft R; Kostka S; Prehn S; Kalies KU; Hartmann E
Mammalian Sec61 is associated with Sec62 and Sec63
Journal of Biological Chemistry 275: 14550-14557 (2000-05-12)
Steffan JS; Kazantsev A; Spasic-Boskovic O; Greenwald M; Zhu YZ; Gohler H; Wanker EE; Bates GP; Housman DE; Thompson LM
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
Proceedings of the National Academy of Sciences of the United States of America 97: 6763-6768 (2000-06-06)
Schwarz K; de Giuli R; Schmidtke G; Kostka S; van den Broek M; Kim KB; Crews CM; Kraft R; Groettrup M
The selective proteasome inhibitors lactacystin and epoxomicin can be used to either up- or down-regulate antigen presentation at nontoxic doses
Journal of Immunology 164: 6147-6157 (2000-06-15)
Pevzner V; Kraft R; Kostka S; Lipp M
Phosphorylation of Oct-2 at sites located in the POU domain induces differential down-regulation of Oct-2 DNA-binding ability
Biochemical Journal 347: 29-35 (2000-04-01)
1999
Heuner K; Choi BK; Schade R; Moter A; Otto A; Goebel UB
Cloning and characterization of a gene (mspA) encoding the major sheath protein Treponema maltophilum ATCC51939(T)
Journal of Bacteriology 181: 1025-1029 (1999-02-01)
Heidenreich O; Neininger A; Schratt G; Zinck R; Cahill MA; Engel K; Kotlyarov A; Kraft R; Kostka S; Gaestel M; Nordheim A
MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo
Journal of Biological Chemistry 274: 14434-14443 (1999-05-14)
Richter R; Hejazi M; Kraft R; Ziegler K; Lockau W
Cyanophycinase, a peptidase degrading the cyanobacterial reserve material multi-L-arginyl-poly-L-aspartic acid (cyanophycin) - Molecular cloning of the gene of Synechocystis sp PCC 6803, expression in Escherichia coli, and biochemical characterization of the purified enzyme
European Journal of Biochemistry 263: 163-169 (1999-07-01)
Hollenbach B; Scherzinger E; Schweiger K; Lurz R; Lehrach H; Wanker EE
Aggregation of truncated GST-HD exon 1 fusion proteins containing normal range and expanded glutamine repeats
Philosophical Transactions of the Royal Society of London Series B Biological Sciences 354: 991-994 (1999-06-29)
Schmidt M; Zantopf D; Kraft R; Kostka S; Preissner R; Kloetzel PM
Sequence information within proteasomal prosequences mediates efficient integration of beta-subunits into the 20 S proteasome complex
Journal of Molecular Biology 288: 117-128 (1999-04-23)
Hutloff A; Dittrich AM; Beier KC; Eljaschewitsch B; Kraft R; Anagnostopoulos I; Kroczek RA
ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
Nature 397 (6716): 263-266 (1999-01-21)
Davies SW; Sathasivam K; Hobbs C; Doherty P; Mangiarini L; Scherzinger E; Wanker EE; Bates GP
Detection of polyglutamine aggregation in mouse models
Methods in Enzymology 309: 687-701 (1999-01-01)
Sathasivam K; Hobbs C; Turmaine M; Mangiarini L; Mahal A; Bertaux F; Wanker EE; Doherty P; Davies SW; Bates GP
Formation of polyglutamine inclusions in non-CNS tissue
Human Molecular Genetics 8: 813-822 (1999-05-01)
Jungblut PR; Zimny-Arndt U; Zeindl-Eberhart E; Stulik J; Koupilova K; Pleissner K-P; Otto A; Mueller EC; Sokolowska-Koehler W; Grabher G; Stoeffler G
Proteomics in human disease: cancer,heart and infectious diseases
Electrophoresis 20 (10): 2100-2110 (1999-07)
Oleskina YP; Yurina NP; Odintsova TI; Egorov TA; Otto A; Wittmann-Liebold B; Odintsova MS
Nucleoid proteins of pea chloroplasts: Detection of a protein homologous to ribosomal protein
Biochemistry and Molecular Biology International 47: 757-763 (1999-05-01)
Schaefer H; Bartels T; Hahn G; Otto A; Burger R
T-cell-activating monoclonal antibodies, reacting with both leukocytes and erythrocytes, recognize the guinea pig Thy-1 differentiation antigen: Characterization and cloning of guinea pig CD90
Cellular Immunology 197: 116-128 (1999-11-01)
Sieradzan KA; Mechan AO; Jones L; Wanker EE; Nukina N; Mann DM
Huntington's disease intranuclear inclusions contain truncated, ubiquitinated huntingtin protein
Experimental Neurology 156 (1): 92-99 (1999-03-01)
Wanker EE; Scherzinger E; Heiser V; Sittler A; Eickhoff H; Lehrach H
Membrane filter assay for detection of amyloid-like polyglutamine-containing protein aggregates
Methods in Enzymology 309: 375-386 (1999-01-01)
Haase H; Podzuweit T; Lutsch G; Hohaus A; Kostka S; Lindschau C; Kott M; Kraft R; Morano I
Signaling from beta-adrenoceptor to L-type calcium channel: identification of a novel cardiac protein kinase A target possessing similarities to AHNAK
FASEB Journal 13: 2161-2172 (1999-01-01)
Starikov EB; Lehrach H; Wanker EE
Folding of oligoglutamines: a theoretical approach based upon thermodynamics and molecular mechanics
Journal of Biomolecular Structure & Dynamics 17: 409-427 (1999-12-01)
Mueller EC; Schuemann M; Rickers A; Bommert K; Wittmann-Liebold B; Otto A
Study of Burkitt lymphoma cell line proteins by high resolution two-dimensional gel electrophoresis and nanoelectrospray mass spectrometry
Electrophoresis 20: 320-330 (1999-02-01)
Scherzinger E; Sittler A; Schweiger K; Heiser V; Lurz R; Hasenbank R; Bates GP; Lehrach H; Wanker EE
Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology
Proceedings of the National Academy of Sciences of the United States of America 96 (8): 4604-4609 (1999-04-13)
Koroljova OV; Stepanova EV; Gavrilova VP; Biniukov VI; Jaropolov AI; Varfolomeyev SD; Scheller FW; Makower A; Otto A
Laccase of Coriolus zonatus - Isolation, purification, and some physicochemical properties
Applied Biochemistry and Biotechnology 76: 115-127 (1999-02-01)
Brockstedt E; Otto A; Rickers A; Bommert K; Wittmann-Liebold B
Preparative high-resolution two-dimensional electrophoresis enables the identification of RNA polymerase B transcription factor 3 as an apoptosis-associated protein in the human BL60-2 Burkitt lymphoma cell line
Journal of Protein Chemistry 18: 225-231 (1999-02-01)
Leheste JR; Rolinski B; Vorum H; Hilpert J; Nykjaer A; Jacobsen C; Aucouturier P; Moskaug JO; Otto A; Christensen EI; Willnow TE
Megalin knockout mice as an animal model of low molecular weight proteinuria
American Journal of Pathology 155 (4): 1361-1370 (1999-10-01)
Braun BC; Glickman M; Kraft R; Dahlmann B; Kloetzel PM; Finley D; Schmidt M
The base of the proteasome regulatory particle exhibits chaperone-like activity
Nature Cell Biology 1 (4): 221-226 (1999-08-01)
1998
Boettger M; Zaitsev SV; Otto A; Haberland A; Vorob'ev VI
Acid nuclear extracts as mediators of gene transfer and expression
Biochimica et Biophysica Acta 1395: 78-87 (1998-01-01)
Seeger M; Kraft R; Ferrell K; Bech-Otschir D; Dumedey R; Schade R; Gordon C; Naumann M; Dubiel W
A novel protein complex involved in signaltransduction processing similarities to 26S proteasome subunits
FASEB Journal 12 (6): 469-478 (1998-04-01)
Himmelbauer H; Wedemeyer N; Haaf T; Wanker EE; Schalkwyk LC; Lehrach H
IRS-PCR-based genetic mapping of the huntingtin interacting protein gene (HIP1) on mouse chromosome 5
Mammalian Genome 9: 26-31 (1998-01-01)
Otto A; Mueller EC; Brockstedt E; Schumann M; Rickers A; Bommert K; Wittmann-Liebold B
High performance two dimensional gel electrophoresis and nanoelectrospray mass spectrometry as powerful tool to study apoptosis-associated processes in a Burkitt lymphoma cell line
Journal of Protein Chemistry 17: 564-565 (1998-08-01)
Tait D; Riccio M; Sittler A; Scherzinger E; Santi S; Ognibene A; Maraldi NM; Lehrach H; Wanker EE
Ataxin-3 is transported into the nucleus and associates with the nuclear matrix
Human Molecular Genetics 7 (6): 991-997 (1998-06)
Rickers A; Brockstedt E; Mapara MY; Otto A; Doerken B; Bommert K
Inhibition of CPP32 blocks surface IgM-mediated apoptosis and D4-GDI cleavage in human BL 60 Burkitt lymphoma cells
European Journal of Immunology 28: 296-304 (1998-01-01)
Jungblut PR; Otto A; Favor J; Loewe M; Mueller EC; Kastner M; Sperling K; Klose J
Identification of mouse crystallins in 2D protein patterns by sequencing and mass spectrometry. Application to cataract mutants
FEBS Letters 435: 131-137 (1998-09-18)
Behlke J; Heidrich K; Naumann M; Mueller EC; Otto A; Reuter R; Kriegel T
Hexokinase 2 from Saccharomyces cerevisiae: regulation of oligomeric structure by in vivo phosphorylation at serine-14
Biochemistry 37: 11989-11995 (1998-01-01)
Georgalis Y; Starikov EB; Hollenbach B; Lurz R; Scherzinger E; Saenger W; Lehrach H; Wanker EE
Huntingtin aggregation monitored by dynamic light scattering
Proceedings of the National Academy of Sciences of the United States of America 95 (11): 6118-6121 (1998-05-26)
Saalbach A; Kraft R; Herrmann K; Haustein UF; Anderegg U
The monoclonal antibody AS02 recognizes a protein on human fibroblasts being highly homologous to Thy-1
Archives of Dermatological Research 290: 360-366 (1998-07-01)
Brockstedt E; Rickers A; Kostka S; Laubersheimer A; Doerken B; Wittmann-Liebold B; Bommert K; Otto A
Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line - cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3
Journal of Biological Chemistry 273 (43): 28057-28064 (1998-10-23)
Bertaux F; Sharp AH; Ross CA; Lehrach H; Bates GP; Wanker EE
HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice
FEBS Letters 426: 229-232 (1998-04-17)
Sittler A; Walter S; Wedemeyer N; Hasenbank R; Scherzinger E; Eickhoff H; Bates GP; Lehrach H; Wanker EE
SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates
Molecular Cell 2 (4): 427-436 (1998-10)
Hayess K; Kraft R; Sachsinger J; Janke J; Jandrig B; Beckmann G; Rohde K; Benndorf R
Mammalian protein homologous to VAT-1 of torpedo californica: isolation from Ehrlich Ascites Tumor cells, biochemical characterization and organization of its gene
Journal of Cellular Biochemistry 69: 304-315 (1998-01-01)
Bates GP; Mangiarini L; Wanker EE; Davies SW
Polyglutamine expansion and Huntington's disease
Biochemical Society Transactions 26: 471-475 (1998-08-01)
Thiede B; Urlaub H; Neubauer H; Grelle G; Wittmann-Liebold B
Precise determination of RNA-protein contact sites in the 50 S ribosomal subunit of Escherichia coli
Biochemical Journal 334 P.1: 39-42 (1998-08-15)
Zechner U; Scheel S; Hemberger M; Hopp M; Haaf T; Fundele R; Wanker EE; Lehrach H; Wedemeyer N; Himmelbauer H
Characterization of the mouse Src homology 3 domain gene Sh3d2c on Chr 7 demonstrates coexpression with huntingtin in the brain and identifies the processed pseudogene Sh3d2c-ps1 on Chr 2
Genomics 54: 505-510 (1998-12-15)
1997
Schumacher S; Volkmer H; Buck F; Otto A; Tarnok A; Roth S; Rathjen FG
Chicken acidic leucine-rich EGF-like domain containing brain protein (CALEB), a neural member of the EGF family of differentiation factors, is implicated in neurite formation
Journal of Cell Biology 136 (4): 895-906 (1997-02-24)
Wanker EE; Rovira C; Scherzinger E; Hasenbank R; Walter S; Tait D; Colicelli J; Lehrach H
HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system
Human Molecular Genetics 6 (3): 487-495 (1997-03-01)
Scheler C; Mueller EC; Stahl J; Mueller-Werdan U; Salnikov J; Jungblut P
Identification and characterization of heat shock protein 27 protein species in human myocardial two-dimensional electrophoresis patterns
Electrophoresis 18: 2823-2831 (1997-01-01)
Scherzinger E; Lurz R; Turmaine M; Mangiarini L; Hollenbach B; Hasenbank R; Bates GP; Davies SW; Lehrach H; Wanker EE
Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo
Cell 90 (3): 549-558 (1997-08-08)
Davies SW; Turmaine M; Cozens BA; DiFiglia M; Sharp AH; Ross CA; Scherzinger E; Wanker EE; Mangiarini L; Bates GP
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
Cell 90 (3): 537-548 (1997-08-08)
Kutay U; Bischoff FR; Kostka S; Kraft R; Goerlich D
Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor
Cell 90: 1061-1071 (1997-01-01)
Wedemeyer N; Peoples R; Himmelbauer H; Lehrach H; Francke U; Wanker EE
Localization of the human HIP1 gene close to the elastin (ELN) locus on 7q11.23
Genomics 46: 313-315 (1997-12-01)
Dorner B; Mueller S; Entschladen F; Schroeder JM; Frankel P; Kraft R; Friedl P; Clarklewis I; Kroczek RA
Purification, structural analysis, and function of natural atac, a cytokine secreted by cd8(+) T cells
Journal of Biological Chemistry 272: 8817-8823 (1997-01-01)
1995
Wanker EE; Sun Y; Savitz AJ; Meyer DI
Functional characterization of the 180-kD ribosome receptor in vivo
Journal of Cell Biology 130 (1): 29-39 (1995-07)
Wanker EE; Huber A; Schwab H
Purification and characterization of the Bacillus subtilis levanase produced in Escherichia coli
Applied and Environmental Microbiology 61: 1953-1958 (1995-05-01)
Wanker EE; Leer RJ; Pouwels PH; Schwab H
Expression of Bacillus subtilis levanase gene in Lactobacillus plantarum and Lactobacillus casei
Applied Microbiology and Biotechnology 43: 297-303 (1995-05-01)
Wanker EE; Klingsbichel E; Schwab H
Efficient secretion of Bacillus subtilis levanase by Saccharomyces cerevisiae
Gene 161: 45-49 (1995-08-08)
1991
Wanker EE; Schorgendorfer K; Schwab H
Expression of the Bacillus subtilis levanase gene in Escherichia coli and Saccharomyces cerevisiae
Journal of Biotechnology 18: 243-254 (1991-05-01)