Temperature Detection and Thermoregulation
One of our main research interests is centered on somatosensation with a particular emphasis on TRP ion channels that mediate pain and temperature perception. Using a combination of different research methods such as mouse genetics, biochemestry, electrophysiology and functional imaging, we are studying TRP channel function & modulation under physiological and pathological conditions.
Another research focus is geared towards the elucidation of cellular and molecular mechanisms underlying temperature detection and core body temperature regulation. Temperature stability within a narrow range is of critical importance for our well-being and survival. We aim to to identify and characterize cellular substrates and molecular components involved in temperature homeostasis.