Ausgewählte Publikationen


Rathjen T.; Yan X.; Kononenko N.L.; Ku M.C.; Song K.; Ferrarese L.; Tarallo V.; Puchkov D.; Kochlamazashvili G.; Brachs S.; Varela L.; Szigeti-Buck K.; Yi C.X.; Schriever S.C.; Tattikota S.G.; Carlo A.S.; Moroni M.; Siemens J.; Heuser A.; van der Weyden L.; Birkenfeld A.L.; Niendorf T.; Poulet J.F.A.; Horvath T.L.; Tschoep M.H.; Heinig M.; Trajkovski M.; Haucke V.; Poy M.N.
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1
Nature Neuroscience 20 (8): 1096-1103 (2017-08)


Glerup S.; Bolcho U.; Molgaard S.; Boggild S.; Vaegter C.B.; Smith A.H.; Nieto-Gonzalez J.L.; Ovesen P.L.; Pedersen L.F.; Fjorback A.N.; Kjolby M.; Login H.; Holm M.M.; Andersen O.M.; Nyengaard J.R.; Willnow T.E.; Jensen K.; Nykjaer A.
SorCS2 is required for BDNF-dependent plasticity in the hippocampus
Molecular Psychiatry 21 (12): 1740-1751 (2016-12)

Andersen O.M.; Rudolph I.M.; Willnow T.E.
Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease
Acta Neuropathologica 132 (5): 653-665 (2016-11)

Nasrallah R.; Fast E.M.; Solaimani P.; Knezevic K.; Eliades A.; Patel R.; Thambyrajah R.; Unnikrishnan A.; Thoms J.; Beck D.; Vink C.S.; Smith A.; Wong J.; Shepherd M.; Kent D.; Roychoudhuri R.; Paul F.; Klippert J.; Hammes A.; Willnow T.; Goettgens B.; Dzierzak E.; Zon L.I.; Lacaud G.; Kouskoff V.; Pimanda J.E.
Identification of novel regulators of developmental hematopoiesis using endoglin regulatory elements as molecular probes
Blood 128 (15): 1928-1939 (2016-10-13)

Schmidt V.; Schulz N.; Yan X.; Schuermann A.; Kempa S.; Kern M.; Blueher M.; Poy M.N.; Olivecrona G.; Willnow T.E.
SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity
Journal of Clinical Investigation 126 (7): 2706-2720 (2016-07-01)


Kooij G.; Kopplin K.; Blasig R.; Stuiver M.; Koning N.; Goverse G.; van der Pol S.M.A.; van het Hof B.; Gollasch M.; Drexhage J.A.R.; Reijerkerk A.; Meij I.C.; Mebius R.; Willnow T.E.; Mueller D.; Blasig I.E.; de Vries H.E.
Disturbed function of the blood-cerebrospinal fluid barrier aggravates neuro-inflammation
Acta Neuropathologica 128 (2): 267-277 (2014-08)

Glerup S.; Olsen D.; Vaegter C.B.; Gustafsen C.; Sjoegaard S.S.; Hermey G.; Kjolby M.; Molgaard S.; Ulrichsen M.; Boggild S.; Skeldal S.; Fjorback A.N.; Nyengaard J.R.; Jacobsen J.; Bender D.; Bjarkam C.R.; Sorensen E.S.; Fuechtbauer E.M.; Eichele G.; Madsen P.; Willnow T.E.; Petersen C.M.; Nykjaer A.
SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia
Neuron 82 (5): 1074-87 (2014-06-04)

Caglayan S.; Takagi-Niidome S.; Liao F.; Carlo A.S.; Schmidt V.; Burgert T.; Kitago Y.; Fuechtbauer E.M.; Fuechtbauer A.; Holtzman D.M.; Takagi J.; Willnow T.E.
Lysosomal sorting of amyloid-{beta} by the SORLA receptor is impaired by a familial Alzheimer's disease mutation
Science Translational Medicine 6 (223): 223ra20 (2014-02-12)


Herda S.; Raczkowski F.; Mittruecker H.W.; Willimsky G.; Gerlach K.; Kuehl A.A.; Breiderhoff T.; Willnow T.E.; Doerken B.; Hoepken U.E.; Rehm A.
The sorting receptor sortilin exhibits a dual function in exocytic trafficking of interferon-{gamma} and granzyme A in T cells
Immunity 37 (5): 854-866 (2012-11-16)

Nykjaer A.; Willnow T.E.
Sortilin: a receptor to regulate neuronal viability and function
Trends in Neurosciences 35 (4): 261-270 (2012-04)

Christ A.; Christa A.; Kur E.; Lioubinski O.; Bachmann S.; Willnow T.E.; Hammes A.
LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals
Developmental Cell 22 (2): 268-278 (2012-02-14)


Stuiver M.; Lainez S.; Will C.; Terryn S.; Guenzel D.; Debaix H.; Sommer K.; Kopplin K.; Thumfart J.; Kampik N.B.; Querfeld U.; Willnow T.E.; Nemec V.; Wagner C.A.; Hoenderop J.G.; Devuyst O.; Knoers N.V.; Bindels R.J.; Meij I.C.; Mueller D.
CNNM2, encoding a basolateral protein required for renal Mg(2+) handling, is mutated in dominant hypomagnesemia
American Journal of Human Genetics 88 (3): 333-343 (2011-03-11)

Vaegter C.B.; Jansen P.; Fjorback A.W.; Glerup S.; Skeldal S.; Kjolby M.; Richner M.; Erdmann B.; Nyengaard J.R.; Tessarollo L.; Lewin G.R.; Willnow T.E.; Chao M.V.; Nykjaer A.
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling
Nature Neuroscience 14 (1): 54-61 (2011-01)


Kjolby M.; Andersen O.M.; Breiderhoff T.; Fjorback A.W.; Pedersen K.M.; Madsen P.; Jansen P.; Heeren J.; Willnow T.E.; Nykjaer A.
Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export
Cell Metabolism 12 (3): 213-223 (2010-09-08)


Ceccarini G.; Flavell R.R.; Butelman E.R.; Synan M.; Willnow T.E.; Bar-Dagan M.; Goldsmith S.J.; Kreek M.J.; Kothari P.; Vallabhajosula S.; Muir T.W.; Friedman J.M.
PET imaging of leptin biodistribution and metabolism in rodents and primates
Cell Metabolism 10 (2): 148-159 (2009-08-06)


Willnow T.E.; Petersen C.M.; Nykjaer A.
VPS10P-domain receptors - regulators of neuronal viability and function
Nature Reviews Neuroscience 9 (12): 899-909 (2008-12)


Jansen P.; Giehl K.; Nyengaard J.R.; Teng K.; Lioubinski O.; Sjoegaard S.S.; Breiderhoff T.; Gotthardt M.; Lin F.; Eilers A.; Petersen C.M.; Lewin G.R.; Hempstead B.L.; Willnow T.E.; Nykjaer A.
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury
Nature Neuroscience 10 (11): 1449-1457 (2007-11)

Rogaeva E.; Meng Y.; Lee J.H.; Gu Y.; Kawarai T.; Zou F.; Katayama T.; Baldwin C.T.; Cheng R.; Hasegawa H.; Chen F.; Shibata N.; Lunetta K.L.; Pardossi-Piquard R.; Bohm C.; Wakutani Y.; Cupples L.A.; Cuenco K.T.; Green R.C.; Pinessi L.; Rainero I.; Sorbi S.; Bruni A.; Duara R.; Friedland R.P.; Inzelberg R.; Hampe W.; Bujo H.; Song Y.Q.; Andersen O.M.; Willnow T.E.; Graff-Radford N.; Petersen R.C.; Dickson D.; Der S.D.; Fraser P.E.; Schmitt-Ulms G.; Younkin S.; Mayeux R.; Farrer L.A.; St George-Hyslop P.
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
Nature Genetics 39 (2): 168-177 (2007-02)


Andersen O.M.; Willnow T.E.
Lipoprotein receptors in Alzheimer's disease
Trends in Neurosciences 29 (12): 687-694 (2006-12)

Donath S.; Li P.; Willenbockel C.; Al-Saadi N.; Gross V.; Willnow T.E.; Bader M.; Martin U.; Bauersachs J.; Wollert K.C.; Dietz R.; von Harsdorf R.
Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress
Circulation 113 (9): 1203-1212 (2006-03-07)


Hammes A.; Andreassen T.K.; Spoelgen R.; Raila J.; Huebner N.; Schulz H.; Metzger J.; Schweigert F.J.; Luppa P.B.; Nykjaer A.; Willnow T.E.
Role of endocytosis in cellular uptake of sex steroids
Cell 122 (5): 751-762 (2005-09-09)

Andersen O.M.; Reiche J.; Schmidt V.; Gotthardt M.; Spoelgen R.; Behlke J.; von Arnim C.A.F.; Breiderhoff T.; Jansen P.; Wu X.; Bales K.R.; Cappai R.; Masters C.L.; Gliemann J.; Mufson E.J.; Hyman B.T.; Paul S.M.; Nykjaer A.; Willnow T.E.
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein
Proceedings of the National Academy of Sciences of the United States of America 102 (38): 13461-13466 (2005-09-07)


Nykjaer A.; Lee R.; Teng K.K.; Jansen P.; Madsen P.; Nielsen M.S.; Jacobsen C.; Kliemannel M.; Schwarz E.; Willnow T.E.; Hempstead B.L.; Petersen C.M.
Sortilin is essential for proNGF-induced neuronal cell death
Nature 427 (6977): 843-848 (2004-02-26)


Lisi S.; Pinchera A.; McCluskey R.T.; Willnow T.E.; Refetoff S.; Marcocci C.; Vitti P.; Menconi F.; Grasso L.; Luchetti F.; Collins A.B.; Marino M.
Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: A control mechanism for thyroid hormone release
Proceedings of the National Academy of Sciences of the United States of America 100 (25): 14858-14863 (2003-01-01)


Nykjaer A.; Willnow T.E.
The low-density lipoprotein receptor gene family: a cellular Swiss army knife?
Trends in Cell Biology 12 (6): 273-280 (2002-06-01)


Nykjaer A.; Fyfe J.C.; Kozyraki R.; Leheste J.R.; Jacobsen C.; Nielsen M.S.; Verroust P.J.; Aminoff M.; de la Chapelle A.; Moestrup S.K.; Ray R.; Gliemann J.; Willnow T.E.; Christensen E.I.
Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D-3
Proceedings of the National Academy of Sciences of the United States of America 98 (24): 13895-13900 (2001-01-01)

Kozyraki R.; Fyfe J.; Verroust P.J.; Jacobsen C.; Dautry-Varsat A.; Gburek J.; Willnow T.E.; Christensen E.I.; Moestrup S.K.
Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia
Proceedings of the National Academy of Sciences of the United States of America 98 (22): 12491-12496 (2001-01-01)


Birn H.; Fyfe J.C.; Jacobsen C.; Mounier F.; Verroust P.J.; Orskov H.; Willnow T.E.; Moestrup S.K.; Christensen E.I.
Cubilin is an albumin binding protein important for renal tubular albumin reabsorption
Journal of Clinical Investigation 105 (10): 1353-1361 (2000-05)


Nykjaer A.; Dragun D.; Walther D.; Vorum H.; Jacobsen C.; Herz J.; Melsen F.; Christensen E.I.; Willnow T.E.
An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D-3
Cell 96 (4): 507-515 (1999-02-19)


Herz J.; Willnow T.E.; Farese R.V.
Cholesterol, hedgehog and embryogenesis
Nature Genetics 15 (2): 123-124 (1997-02)


Sinnis P.; Willnow T.E.; Briones M.R.; Herz J.; Nussenzweig V.
Remnant lipoproteins inhibit malaria sporozoite invasion of hepatocytes
Journal of Experimental Medicine 184 (3): 945-954 (1996-09-01)

Willnow T.E.; Hilpert J.; Armstrong S.A.; Rohlmann A.; Hammer R.E.; Burns D.K.; Herz J.
Defective forebrain development in mice lacking gp330/megalin
Proceedings of the National Academy of Sciences of the United States of America 93 (16): 8460-8464 (1996-08-06)

Willnow T.E.; Rohlmann A.; Horton J.; Otani H.; Braun J.R.; Hammer R.E.; Herz J.
RAP, a specialized chaperone, prevents ligand-induced er retention and degradation of LDL receptor-related endocytic receptors
EMBO Journal 15 (11): 2632-2639 (1996-01-01)


Willnow T.E.; Armstrong S.A.; Hammer R.E.; Herz J.
Functional expression of low density lipoprotein receptor- related protein is controlled by receptor-associated protein in vivo
Proceedings of the National Academy of Sciences of the United States of America 92 (10): 4537-4541 (1995-05-09)


Willnow T.E.; Sheng Z.; Ishibashi S.; Herz J.
Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist
Science 264 (5164): 1471-1474 (1994-06-03)