Selected Publications



2017

Huang T.Y.; Zhao Y.; Jiang L.L.; Li X.; Liu Y.; Sun Y.; Pina-Crespo J.C.; Zhu B.; Masliah E.; Willnow T.E.; Pasquale E.B.; Xu H.
SORLA attenuates EphA4 signaling and amyloid, {beta}-induced neurodegeneration
Journal of Experimental Medicine 214 (12): 3669-3685 (2017-12-04)



Yan X.; Wang Z.; Schmidt V.; Gauert A.; Willnow T.E.; Heinig M.; Poy M.N.
Cadm2 regulates body weight and energy homeostasis in mice
Molecular Metabolism : (2017-11-22)



Breiderhoff T.; Himmerkus N.; Drewell H.; Plain A.; Guenzel D.; Mutig K.; Willnow T.E.; Mueller D.; Bleich M.
Deletion of claudin-10 rescues claudin-16-deficient mice from hypomagnesemia and hypercalciuria
Kidney International : (2017-11-10)



Eggert S.; Gonzalez A.C.; Thomas C.; Schilling S.; Schwarz S.M.; Tischer C.; Adam V.; Strecker P.; Schmidt V.; Willnow T.E.; Hermey G.; Pietrzik C.U.; Koo E.H.; Kins Stefan
Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA
Cellular and Molecular Life Sciences : (2017-08-10)



Rathjen T.; Yan X.; Kononenko N.L.; Ku M.C.; Song K.; Ferrarese L.; Tarallo V.; Puchkov D.; Kochlamazashvili G.; Brachs S.; Varela L.; Szigeti-Buck K.; Yi C.X.; Schriever S.C.; Tattikota S.G.; Carlo A.S.; Moroni M.; Siemens J.; Heuser A.; van der Weyden L.; Birkenfeld A.L.; Niendorf T.; Poulet J.F.A.; Horvath T.L.; Tschoep M.H.; Heinig M.; Trajkovski M.; Haucke V.; Poy M.N.
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1
Nature Neuroscience 20 (8): 1096-1103 (2017-08)



Cases O.; Obry A.; Ben-Yacoub S.; Augustin S.; Joseph A.; Toutirais G.; Simonutti M.; Christ A.; Cosette P.; Kozyraki R.
Impaired vitreous composition and retinal pigment epithelium function in the FoxG1::LRP2 myopic mice
Biochimica et Biophysica Acta - Molecular Cell Research 1863 (6): 1242-1254 (2017-06)



Schmidt V.; Subkhangulova A.; Willnow T.E.
Sorting receptor SORLA: cellular mechanisms and implications for disease
Cellular and Molecular Life Sciences 74 (8): 1475-1483 (2017-04)



Willnow T.E.
Nanotubes, the fast track to treatment of Dent disease?
Kidney International 91 (4): 776-778 (2017-04)



2016

Glerup S.; Bolcho U.; Molgaard S.; Boggild S.; Vaegter C.B.; Smith A.H.; Nieto-Gonzalez J.L.; Ovesen P.L.; Pedersen L.F.; Fjorback A.N.; Kjolby M.; Login H.; Holm M.M.; Andersen O.M.; Nyengaard J.R.; Willnow T.E.; Jensen K.; Nykjaer A.
SorCS2 is required for BDNF-dependent plasticity in the hippocampus
Molecular Psychiatry 21 (12): 1740-1751 (2016-12)



Andersen O.M.; Rudolph I.M.; Willnow T.E.
Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease
Acta Neuropathologica 132 (5): 653-665 (2016-11)



Campbell C.; Beug S.; Nickerson P.E.B.; Peng J.; Mazerolle C.; Bassett E.; Ringuette R.; Jama F.A.; Morales C.; Christ A.; Wallace V.A.
Sortilin regulates sorting and secretion of Sonic hedgehog
Journal of Cell Science 129 (20): 3832-3844 (2016-10-15)



Nasrallah R.; Fast E.M.; Solaimani P.; Knezevic K.; Eliades A.; Patel R.; Thambyrajah R.; Unnikrishnan A.; Thoms J.; Beck D.; Vink C.S.; Smith A.; Wong J.; Shepherd M.; Kent D.; Roychoudhuri R.; Paul F.; Klippert J.; Hammes A.; Willnow T.; Goettgens B.; Dzierzak E.; Zon L.I.; Lacaud G.; Kouskoff V.; Pimanda J.E.
Identification of novel regulators of developmental hematopoiesis using endoglin regulatory elements as molecular probes
Blood 128 (15): 1928-1939 (2016-10-13)



Hartl D.; Nebrich G.; Klein O.; Stephanowitz H.; Krause E.; Rohe M.
SORLA regulates calpain-dependent degradation of synapsin
Alzheimer's & Dementia 12 (9): 952-963 (2016-09)



Huang T.Y.; Zhao Y.; Li X.; Wang X.; Tseng I.C.; Thompson R.; Tu S.; Willnow T.E.; Zhang Y.W.; Xu H.
SNX27 and SORLA interact to reduce amyloidogenic subcellular distribution and processing of amyloid precursor protein
Journal of Neuroscience 36 (30): 7996-8011 (2016-07-27)



Schmidt V.; Schulz N.; Yan X.; Schuermann A.; Kempa S.; Kern M.; Blueher M.; Poy M.N.; Olivecrona G.; Willnow T.E.
SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity
Journal of Clinical Investigation 126 (7): 2706-2720 (2016-07-01)



Schmidt V.; Willnow T.E.
Protein sorting gone wrong - VPS10P domain receptors in cardiovascular and metabolic diseases
Atherosclerosis 245: 194-199 (2016-02)



Borschewski A.; Himmerkus N.; Boldt C.; Blankenstein K.I.; McCormick J.A.; Lazelle R.; Willnow T.E.; Jankowski V.; Plain A.; Bleich M.; Ellison D.H.; Bachmann S.; Mutig K.
Calcineurin and sorting-related receptor with A-type repeats interact to regulate the renal Na(+)-K(+)-2Cl(-) cotransporter
Journal of the American Society of Nephrology 27 (1): 107-119 (2016-01)



2015

Reuter E.; Weber J.; Paterka M.; Ploen R.; Breiderhoff T.; van Horssen J.; Willnow T.E.; Siffrin V.; Zipp F.
Role of sortilin in models of autoimmune neuroinflammation
Journal of Immunology 195 (12): 5762-5769 (2015-12-15)



Christ A.; Christa A.; Klippert J.; Eule J.C.; Bachmann S.; Wallace V.A.; Hammes A.; Willnow T.E.
LRP2 acts as SHH clearance receptor to protect the retinal margin from mitogenic stimuli
Developmental Cell 35 (1): 36-48 (2015-10-12)



Dumanis S.B.; Burgert T.; Caglayan S.; Fuechtbauer A.; Fuechtbauer E.M.; Schmidt V.; Willnow T.E.
Distinct functions for anterograde and retrograde sorting of SORLA in amyloidogenic processes in the brain
Journal of Neuroscience 35 (37): 12703-12713 (2015-09-16)



2014

Carlo A.S.; Nykjaer A.; Willnow T.E.
Sorting receptor sortilin-a culprit in cardiovascular and neurological diseases
Journal of Molecular Medicine 92 (9): 905-911 (2014-09)



Kooij G.; Kopplin K.; Blasig R.; Stuiver M.; Koning N.; Goverse G.; van der Pol S.M.A.; van het Hof B.; Gollasch M.; Drexhage J.A.R.; Reijerkerk A.; Meij I.C.; Mebius R.; Willnow T.E.; Mueller D.; Blasig I.E.; de Vries H.E.
Disturbed function of the blood-cerebrospinal fluid barrier aggravates neuro-inflammation
Acta Neuropathologica 128 (2): 267-277 (2014-08)



Glerup S.; Olsen D.; Vaegter C.B.; Gustafsen C.; Sjoegaard S.S.; Hermey G.; Kjolby M.; Molgaard S.; Ulrichsen M.; Boggild S.; Skeldal S.; Fjorback A.N.; Nyengaard J.R.; Jacobsen J.; Bender D.; Bjarkam C.R.; Sorensen E.S.; Fuechtbauer E.M.; Eichele G.; Madsen P.; Willnow T.E.; Petersen C.M.; Nykjaer A.
SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia
Neuron 82 (5): 1074-87 (2014-06-04)



Kur E.; Mecklenburg N.; Cabrera R.M.; Willnow T.E.; Hammes A.
LRP2 mediates folate uptake in the developing neural tube
Journal of Cell Science 127 (Pt 10): 2261-2268 (2014-05-15)



Caglayan S.; Takagi-Niidome S.; Liao F.; Carlo A.S.; Schmidt V.; Burgert T.; Kitago Y.; Fuechtbauer E.M.; Fuechtbauer A.; Holtzman D.M.; Takagi J.; Willnow T.E.
Lysosomal sorting of amyloid-{beta} by the SORLA receptor is impaired by a familial Alzheimer's disease mutation
Science Translational Medicine 6 (223): 223ra20 (2014-02-12)



2013

Burgert T.; Schmidt V.; Caglayan S.; Lin F.; Fuechtbauer A.; Fuechtbauer E.M.; Nykjaer A.; Carlo A.S.; Willnow T.E.
SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes
Molecular and Cellular Biology 33 (21): 4308-4320 (2013-11)



Willnow T.E.; Andersen O.M.
Sorting receptor SORLA - a trafficking path to avoid Alzheimer disease
Journal of Cell Science 126 (Pt 13): 2751-2760 (2013-07-01)



Carlo A.S.; Gustafsen C.; Mastrobuoni G.; Nielsen M.S.; Burgert T.; Hartl D.; Rohe M.; Nykjaer A.; Herz J.; Heeren J.; Kempa S.; Petersen C.M.; Willnow T.E.
The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-beta peptide in the brain
Journal of Neuroscience 33 (1): 358-370 (2013-01-02)



2012

Willnow T.E.; Christ A.; Hammes A.
Endocytic receptor-mediated control of morphogen signaling
Development 139 (23): 4311-4319 (2012-12-01)



Herda S.; Raczkowski F.; Mittruecker H.W.; Willimsky G.; Gerlach K.; Kuehl A.A.; Breiderhoff T.; Willnow T.E.; Doerken B.; Hoepken U.E.; Rehm A.
The sorting receptor sortilin exhibits a dual function in exocytic trafficking of interferon-{gamma} and granzyme A in T cells
Immunity 37 (5): 854-866 (2012-11-16)



Breiderhoff T.; Himmerkus N.; Stuiver M.; Mutig K.; Will C.; Meij I.C.; Bachmann S.; Bleich M.; Willnow T.E.; Mueller D.
Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis
Proceedings of the National Academy of Sciences of the United States of America 109 (35): 14241-14246 (2012-08-28)



Nykjaer A.; Willnow T.E.
Sortilin: a receptor to regulate neuronal viability and function
Trends in Neurosciences 35 (4): 261-270 (2012-04)



Christ A.; Christa A.; Kur E.; Lioubinski O.; Bachmann S.; Willnow T.E.; Hammes A.
LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals
Developmental Cell 22 (2): 268-278 (2012-02-14)



Fjorback A.W.; Seaman M.; Gustafsen C.; Mehmedbasic A.; Gokool S.; Wu C.; Militz D.; Schmidt V.; Madsen P.; Nyengaard J.R.; Willnow T.E.; Christensen E.I.; Mobley W.B.; Nykjaer A.; Andersen O.M.
Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing
Journal of Neuroscience 32 (4): 1467-1480 (2012-01-25)



Schmidt V.; Baum K.; Lao A.; Rateitschak K.; Schmitz Y.; Teichmann A.; Wiesner B.; Petersen C.M.; Nykjaer A.; Wolf J.; Wolkenhauer O.; Willnow T.E.
Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease
EMBO Journal 31 (1): 187-200 (2012-01-04)



2011

Willnow T.E.; Kjolby M.; Nykjaer A.
Sortilins: new players in lipoprotein metabolism
Current Opinion in Lipidology 22 (2): 79-85 (2011-04)



Stuiver M.; Lainez S.; Will C.; Terryn S.; Guenzel D.; Debaix H.; Sommer K.; Kopplin K.; Thumfart J.; Kampik N.B.; Querfeld U.; Willnow T.E.; Nemec V.; Wagner C.A.; Hoenderop J.G.; Devuyst O.; Knoers N.V.; Bindels R.J.; Meij I.C.; Mueller D.
CNNM2, encoding a basolateral protein required for renal Mg(2+) handling, is mutated in dominant hypomagnesemia
American Journal of Human Genetics 88 (3): 333-343 (2011-03-11)



Vaegter C.B.; Jansen P.; Fjorback A.W.; Glerup S.; Skeldal S.; Kjolby M.; Richner M.; Erdmann B.; Nyengaard J.R.; Tessarollo L.; Lewin G.R.; Willnow T.E.; Chao M.V.; Nykjaer A.
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling
Nature Neuroscience 14 (1): 54-61 (2011-01)



2010

Amsellem S.; Gburek J.; Hamard G.; Nielsen R.; Willnow T.E.; Devuyst O.; Nexo E.; Verroust P.J.; Christensen E.I.; Kozyraki R.
Cubilin is essential for albumin reabsorption in the renal proximal tubule
Journal of the American Society of Nephrology 21 (11): 1859-1867 (2010-11)



Kjolby M.; Andersen O.M.; Breiderhoff T.; Fjorback A.W.; Pedersen K.M.; Madsen P.; Jansen P.; Heeren J.; Willnow T.E.; Nykjaer A.
Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export
Cell Metabolism 12 (3): 213-223 (2010-09-08)



Christ A.; Terryn S.; Schmidt V.; Christensen E.I.; Huska M.R.; Andrade-Navarro M.A.; Huebner N.; Devuyst O.; Hammes A.; Willnow T.E.
The soluble intracellular domain of megalin does not affect renal proximal tubular function in vivo
Kidney International 78 (5): 473-477 (2010-09)



Gajera C.R.; Emich H.; Lioubinski O.; Christ A.; Beckervordersandforth-Bonk R.; Yoshikawa K.; Bachmann S.; Christensen E.I.; Goetz M.; Kempermann G.; Peterson A.S.; Willnow T.E.; Hammes A.
LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche
Journal of Cell Science 123 (Pt 11): 1922-1930 (2010-06-01)



Reiche J.; Theilig F.; Rafiqi F.H.; Carlo A.S.; Militz D.; Mutig K.; Todiras M.; Christensen E.I.; Ellison D.H.; Bader M.; Nykjaer A.; Bachmann S.; Alessi D.; Willnow T.E.
SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na+-K+-Cl- cotransporter 2
Molecular and Cellular Biology 30 (12): 3027-3037 (2010-06)



Andersen O.S.; Boisguerin P.; Glerup S.; Skeldal S.; Volkmer R.; Willnow T.E.; Nykjaer A.; Andersen O.M.
Identification of a linear epitope in sortilin that partakes in pro-neurotrophin binding
Journal of Biological Chemistry 285 (16): 12210-12222 (2010-04-16)



Willnow T.E.; Nykjaer A.
Cellular uptake of steroid carrier proteins - mechanisms and implications
Molecular and Cellular Endocrinology 316 (1): 93-102 (2010-03-05)



Zhang J.; Piontek J.; Wolburg H.; Piehl C.; Liss M.; Otten C.; Christ A.; Willnow T.E.; Blasig I.E.; Abdelilah-Seyfried S.
Establishment of a neuroepithelial barrier by Claudin5a is essential for zebrafish brain ventricular lumen expansion
Proceedings of the National Academy of Sciences of the United States of America 107 (4): 1425-1430 (2010-01-26)



2009

Rohe M.; Synowitz M.; Glass R.; Paul S.M.; Nykjaer A.; Willnow T.E.
Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression
Journal of Neuroscience 29 (49): 15472-15478 (2009-12-09)



Ceccarini G.; Flavell R.R.; Butelman E.R.; Synan M.; Willnow T.E.; Bar-Dagan M.; Goldsmith S.J.; Kreek M.J.; Kothari P.; Vallabhajosula S.; Muir T.W.; Friedman J.M.
PET imaging of leptin biodistribution and metabolism in rodents and primates
Cell Metabolism 10 (2): 148-159 (2009-08-06)



2008

Willnow T.E.; Petersen C.M.; Nykjaer A.
VPS10P-domain receptors - regulators of neuronal viability and function
Nature Reviews Neuroscience 9 (12): 899-909 (2008-12)



Dodson S.E.; Andersen O.M.; Karmali V.; Fritz J.J.; Cheng D.; Peng J.; Levey A.I.; Willnow T.E.; Lah J.J.
Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: Evidence for a proximal role in Alzheimer's disease
Journal of Neuroscience 28 (48): 12877-12886 (2008-11-26)



Motoyoshi Y.; Matsusaka T.; Saito A.; Pastan I.; Willnow T.E.; Mizutani S.; Ichikawa I.
Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria
Kidney International 74 (10): 1262-1269 (2008-11-02)



Gailly P.; Jouret F.; Martin D.; Debaix H.; Parreira K.S.; Nishita T.; Blanchard A.; Antignac C.; Willnow T.E.; Courtoy P.J.; Scheinman S.J.; Christensen E.I.; Devuyst O.
A novel renal carbonic anhydrase type III plays a role in proximal tubule dysfunction
Kidney International 74 (1): 52-61 (2008-07-01)



Rohe M.; Carlo A.S.; Breyhan H.; Sporbert A.; Militz D.; Schmidt V.; Wozny C.; Harmeier A.; Erdmann B.; Bales K.R.; Wolf S.A.; Kempermann G.; Paul S.M.; Schmitz D.; Bayer T.A.; Willnow T.E.; Andersen O.M.
Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis
Journal of Biological Chemistry 283 (21): 14826-14834 (2008-05-23)



2007

Schmidt V.; Sporbert A.; Rohe M.; Reimer T.; Rehm A.; Andersen O.M.; Willnow T.E.
SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1
Journal of Biological Chemistry 282 (45): 32956-32964 (2007-11-09)



Jansen P.; Giehl K.; Nyengaard J.R.; Teng K.; Lioubinski O.; Sjoegaard S.S.; Breiderhoff T.; Gotthardt M.; Lin F.; Eilers A.; Petersen C.M.; Lewin G.R.; Hempstead B.L.; Willnow T.E.; Nykjaer A.
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury
Nature Neuroscience 10 (11): 1449-1457 (2007-11)



Willnow T.E.; Hammes A.; Eaton S.
Lipoproteins and their receptors in embryonic development: more than cholesterol clearance
Development 134 (18): 3239-3249 (2007-09)



Theilig F.; Kriz W.; Jerichow T.; Schrade P.; Hahnel B.; Willnow T.E.; Le Hir M.; Bachmann S.
Abrogation of Protein Uptake through Megalin-Deficient Proximal Tubules Does Not Safeguard against Tubulointerstitial Injury
Journal of the American Society of Nephrology 18 (6): 1824-1834 (2007-06)



Nielsen R.; Courtoy P.J.; Jacobsen C.; Dom G.; Lima W.R.; Jadot M.; Willnow T.E.; Devuyst O.; Christensen E.I.
Endocytosis provides a major alternative pathway for lysosomal biogenesis in kidney proximal tubular cells
Proceedings of the National Academy of Sciences of the United States of America 104 (13): 5407-5412 (2007-03-27)



Rogaeva E.; Meng Y.; Lee J.H.; Gu Y.; Kawarai T.; Zou F.; Katayama T.; Baldwin C.T.; Cheng R.; Hasegawa H.; Chen F.; Shibata N.; Lunetta K.L.; Pardossi-Piquard R.; Bohm C.; Wakutani Y.; Cupples L.A.; Cuenco K.T.; Green R.C.; Pinessi L.; Rainero I.; Sorbi S.; Bruni A.; Duara R.; Friedland R.P.; Inzelberg R.; Hampe W.; Bujo H.; Song Y.Q.; Andersen O.M.; Willnow T.E.; Graff-Radford N.; Petersen R.C.; Dickson D.; Der S.D.; Fraser P.E.; Schmitt-Ulms G.; Younkin S.; Mayeux R.; Farrer L.A.; St George-Hyslop P.
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
Nature Genetics 39 (2): 168-177 (2007-02)



2006

Andersen O.M.; Willnow T.E.
Lipoprotein receptors in Alzheimer's disease
Trends in Neurosciences 29 (12): 687-694 (2006-12)



Petersen H.H.; Andreassen T.K.; Breiderhoff T.; Braesen J.H.; Schulz H.; Gross V.; Groene H.J.; Nykjaer A.; Willnow T.E.
Hyporesponsiveness to glucocorticoids in mice genetically deficient for the corticosteroid binding globulin
Molecular and Cellular Biology 26 (19): 7236-7245 (2006-10)



Anzenberger U.; Bit-Avragim N.; Rohr S.; Rudolph F.; Dehmel B.; Willnow T.E.; Abdelilah-Seyfried S.
Elucidation of megalin/LRP2-dependent endocytic transport processes in the larval zebrafish pronephros
Journal of Cell Science 119 (Pt. 10): 2127-2137 (2006-05-15)



Donath S.; Li P.; Willenbockel C.; Al-Saadi N.; Gross V.; Willnow T.E.; Bader M.; Martin U.; Bauersachs J.; Wollert K.C.; Dietz R.; von Harsdorf R.
Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress
Circulation 113 (9): 1203-1212 (2006-03-07)



Spoelgen R.; von Arnim C.A.; Thomas A.V.; Peltan I.D.; Koker M.; Deng A.; Irizarry M.C.; Andersen O.M.; Willnow T.E.; Hyman B.T.
Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme
Journal of Neuroscience 26 (2): 418-428 (2006-01-11)



2005

Hammes A.; Andreassen T.K.; Spoelgen R.; Raila J.; Huebner N.; Schulz H.; Metzger J.; Schweigert F.J.; Luppa P.B.; Nykjaer A.; Willnow T.E.
Role of endocytosis in cellular uptake of sex steroids
Cell 122 (5): 751-762 (2005-09-09)



Andersen O.M.; Reiche J.; Schmidt V.; Gotthardt M.; Spoelgen R.; Behlke J.; von Arnim C.A.F.; Breiderhoff T.; Jansen P.; Wu X.; Bales K.R.; Cappai R.; Masters C.L.; Gliemann J.; Mufson E.J.; Hyman B.T.; Paul S.M.; Nykjaer A.; Willnow T.E.
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein
Proceedings of the National Academy of Sciences of the United States of America 102 (38): 13461-13466 (2005-09-07)



Nykjaer A.; Willnow T.E.; Petersen C.M.
p75NTR - live or let die
Current Opinion in Neurobiology 15 (1): 49-57 (2005-01-01)



Spoelgen R.; Hammes A.; Anzenberger U.; Zechner D.; Andersen O.M.; Jerchow B.; Willnow T.E.
LRP2/megalin is required for patterning of the ventral telencephalon
Development 132 (2): 405-414 (2005-01-01)



2004

Bachmann S.; Schlichting U.; Geist B.; Mutig K.; Petsch T.; Bacic D.; Wagner C.A.; Kaissling B.; Biber J.; Murer H.; Willnow T.E.
Kidney-specific inactivation of the megalin gene impairs trafficking of renal inorganic sodium phosphate cotransporter (NaPi-IIa)
Journal of the American Society of Nephrology 15 (4): 892-900 (2004-04-01)



Nykjaer A.; Lee R.; Teng K.K.; Jansen P.; Madsen P.; Nielsen M.S.; Jacobsen C.; Kliemannel M.; Schwarz E.; Willnow T.E.; Hempstead B.L.; Petersen C.M.
Sortilin is essential for proNGF-induced neuronal cell death
Nature 427 (6977): 843-848 (2004-02-26)



2003

Andersen O.M.; Yeung C.H.; Vorum H.; Wellner M.; Andreassen T.K.; Erdmann B.; Mueller E.C.; Herz J.; Otto A.; Cooper T.G.; Willnow T.E.
Essential role of the apolipoprotein E receptor-2 in sperm development
Journal of Biological Chemistry 278 (26): 23989-23995 (2003-06-27)



Leheste J.R.; Melsen F.; Wellner M.; Jansen P.; Schlichting U.; Renner-Mueller I.; Andreassen T.T.; Wolf E.; Bachmann S.; Nykjaer A.; Willnow T.E.
Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect
FASEB Journal 17 (2): 247-249 (2003-02)



Lisi S.; Pinchera A.; McCluskey R.T.; Willnow T.E.; Refetoff S.; Marcocci C.; Vitti P.; Menconi F.; Grasso L.; Luchetti F.; Collins A.B.; Marino M.
Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: A control mechanism for thyroid hormone release
Proceedings of the National Academy of Sciences of the United States of America 100 (25): 14858-14863 (2003-01-01)



Heibroch Petersen H.; Hilpert J.; Militz D.; Zandler V.; Jacobsen C.; Roebroek A.J.M.; Willnow T.E.
Functional interaction of megalin with the megalin-binding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule
Journal of Cell Science 116: 453-461 (2003-01-01)



2002

Hilpert J.; Wogensen L.; Thykjaer T.; Wellner M.; Schlichting U.; Orntoft T.F.; Bachmann S.; Nykjaer A.; Willnow T.E.
Expression profiling confirms the role of endocytic receptor megalin in renal vitamin D-3 metabolism
Kidney International 62 (5): 1672-1681 (2002-11)



Willnow T.E.; Nykjaer A.
Pathways for kidney-specific uptake of the steroid hormone 25-hydroxyvitamin D(3)
Current Opinion in Lipidology 13 (3): 255-260 (2002-06)



Nykjaer A.; Willnow T.E.
The low-density lipoprotein receptor gene family: a cellular Swiss army knife?
Trends in Cell Biology 12 (6): 273-280 (2002-06-01)



Schmitz C.; Hilpert J.; Jacobsen C.; Boensch C.; Christensen E.I.; Luft F.C.; Willnow T.E.
Megalin deficiency offers protection from renal aminoglycoside accumulation
Journal of Biological Chemistry 277: 618-622 (2002-01-01)



Birn H.; Willnow T.E.; Nielsen R.; Norden A.G.W.; Boensch C.; Moestrup S.K.; Nexo E.; Christensen E.I.
Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B-12
American Journal of Physiology Renal Physiology 282 (3): F408-F416 (2002-01-01)



2001

Hilpert J.; Vorum H.; Burmeister R.; Spoelgen R.; Grishkovskaya I.; Misselwitz R.; Nykjaer A.; Willnow T.E.
Efficient eukaryotic expression system for authentic human sex hormone-binding globulin
Biochemical Journal 360 (3): 609-615 (2001-01-01)



Nykjaer A.; Fyfe J.C.; Kozyraki R.; Leheste J.R.; Jacobsen C.; Nielsen M.S.; Verroust P.J.; Aminoff M.; de la Chapelle A.; Moestrup S.K.; Ray R.; Gliemann J.; Willnow T.E.; Christensen E.I.
Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D-3
Proceedings of the National Academy of Sciences of the United States of America 98 (24): 13895-13900 (2001-01-01)



Kozyraki R.; Fyfe J.; Verroust P.J.; Jacobsen C.; Dautry-Varsat A.; Gburek J.; Willnow T.E.; Christensen E.I.; Moestrup S.K.
Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia
Proceedings of the National Academy of Sciences of the United States of America 98 (22): 12491-12496 (2001-01-01)



Burmeister R.; Boe I.M.; Nykjaer A.; Jacobsen C.; Moestrup S.K.; Verroust P.; Christensen E.I.; Lund J.; Willnow T.E.
A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney
Journal of Biological Chemistry 276 (16): 13295-13301 (2001-01-01)



2000

Sousa M.M.; Norden A.G.W.; Jacobsen C.; Willnow T.E.; Christensen E.I.; Thakker R.V.; Verroust P.J.; Moestrup S.K.; Saraiva M.J.
Evidence for the role of megalin in renal uptake of transthyretin
Journal of Biological Chemistry 275 (49): 38176-38181 (2000-12-08)



Schmitz C.; Gotthardt M.; Hinderlich S.; Leheste J.R.; Gross V.; Vorum H.; Christensen E.I.; Luft F.C.; Takahashi S.; Willnow T.E.
Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor
Journal of Biological Chemistry 275 (20): 15357-15362 (2000-05-19)



Birn H.; Fyfe J.C.; Jacobsen C.; Mounier F.; Verroust P.J.; Orskov H.; Willnow T.E.; Moestrup S.K.; Christensen E.I.
Cubilin is an albumin binding protein important for renal tubular albumin reabsorption
Journal of Clinical Investigation 105 (10): 1353-1361 (2000-05)



Herz J.; Gotthardt M.; Willnow T.E.
Cellular signalling by lipoprotein receptors
Current Opinion in Lipidology 11 (2): 161-166 (2000-04-01)



1999

Christensen E.I.; Willnow T.E.
Essential role of megalin in renal proximal tubule for vitamin homeostasis
Journal of the American Society of Nephrology 10: 2224-2236 (1999-10-01)



Leheste J.R.; Rolinski B.; Vorum H.; Hilpert J.; Nykjaer A.; Jacobsen C.; Aucouturier P.; Moskaug J.O.; Otto A.; Christensen E.I.; Willnow T.E.
Megalin knockout mice as an animal model of low molecular weight proteinuria
American Journal of Pathology 155 (4): 1361-1370 (1999-10-01)



Christensen E.I.; Moskaug J.O.; Vorum H.; Jacobsen C.; Gundersen T.E.; Nykjaer A.; Blomhoff R.; Willnow T.E.; Moestrup S.K.
Evidence for an essential role of megalin in transepithelial transport of retinol
Journal of the American Society of Nephrology 10: 685-695 (1999-04-01)



Hilpert J.; Nykjaer A.; Jacobsen C.; Wallukat G.; Nielsen R.; Moestrup S.K.; Haller H.; Luft F.C.; Christensen E.I.; Willnow T.E.
Megalin antagonizes activation of the parathyroid hormone receptor
Journal of Biological Chemistry 274 (9): 5620-5625 (1999-02-26)



Nykjaer A.; Dragun D.; Walther D.; Vorum H.; Jacobsen C.; Herz J.; Melsen F.; Christensen E.I.; Willnow T.E.
An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D-3
Cell 96 (4): 507-515 (1999-02-19)



1998

Moestrup S.K.; Schousboe I.; Jacobsen C.; Leheste J.R.; Christensen E.I.; Willnow T.E.
beta(2)-glycoprotein-1 (apolipoprotein H) and beta(2)-glycoprotein-1-phospholipid complex harbor a recognition site for the endocytic receptor megalin
Journal of Clinical Investigation 102 (5): 902-909 (1998-09-01)



1997

Herz J.; Willnow T.E.; Farese R.V.
Cholesterol, hedgehog and embryogenesis
Nature Genetics 15 (2): 123-124 (1997-02)



1996

Sinnis P.; Willnow T.E.; Briones M.R.; Herz J.; Nussenzweig V.
Remnant lipoproteins inhibit malaria sporozoite invasion of hepatocytes
Journal of Experimental Medicine 184 (3): 945-954 (1996-09-01)



Braun J.R.; Willnow T.E.; Ishibashi S.; Ashwell G.; Herz J.
The major subunit of the asialoglycoprotein receptor is expressed on the hepatocellular surface in mice lacking the minor receptor subunit
Journal of Biological Chemistry 271 (35): 21160-21166 (1996-08-30)



Willnow T.E.; Hilpert J.; Armstrong S.A.; Rohlmann A.; Hammer R.E.; Burns D.K.; Herz J.
Defective forebrain development in mice lacking gp330/megalin
Proceedings of the National Academy of Sciences of the United States of America 93 (16): 8460-8464 (1996-08-06)



Willnow T.E.; Rohlmann A.; Horton J.; Otani H.; Braun J.R.; Hammer R.E.; Herz J.
RAP, a specialized chaperone, prevents ligand-induced er retention and degradation of LDL receptor-related endocytic receptors
EMBO Journal 15 (11): 2632-2639 (1996-01-01)



1995

Willnow T.E.; Armstrong S.A.; Hammer R.E.; Herz J.
Functional expression of low density lipoprotein receptor- related protein is controlled by receptor-associated protein in vivo
Proceedings of the National Academy of Sciences of the United States of America 92 (10): 4537-4541 (1995-05-09)



Poller W.; Willnow T.E.; Hilpert J.; Herz J.
Differential recognition of alpha1-antitrypsin-elastase and alpha1-antichymotrypsin-cathepsin G complexes by the low density lipoprotein receptor-related protein
Journal of Biological Chemistry 270 (6): 2841-2845 (1995-02-10)



1994

Orth K.; Willnow T.E.; Herz J.; Gething M.J.; Sambrook J.
Low density lipoprotein receptor-related protein is necessary for the internalization of both tissue-type plasminogen activator- inhibitor complexes and free tissue-type plasminogen activator
Journal of Biological Chemistry 269 (33): 21117-21122 (1994-08-19)



Willnow T.E.; Sheng Z.; Ishibashi S.; Herz J.
Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist
Science 264 (5164): 1471-1474 (1994-06-03)



Willnow T.E.; Orth K.; Herz J.
Molecular dissection of ligand binding sites on the low density lipoprotein receptor-related protein
Journal of Biological Chemistry 269 (22): 15827-15832 (1994-06-03)



Willnow T.E.; Herz J.
Genetic deficiency in low density lipoprotein receptor-related protein confers cellular resistance to Pseudomonas exotoxin A. Evidence that this protein is required for uptake and degradation of multiple ligands
Journal of Cell Science 107 (Pt 3): 719-726 (1994-03)



1992

Willnow T.E.; Goldstein J.L.; Orth K.; Brown M.S.; Herz J.
Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance
Journal of Biological Chemistry 267 (36): 26172-26180 (1992-12-25)