Publications



2017

Kammertoens T.; Friese C.; Arina A.; Idel C.; Briesemeister D.; Rothe M.; Ivanov A.; Szymborska A.; Patone G.; Kunz S.; Sommermeyer D.; Engels B.; Leisegang M.; Textor A.; Fehling H.J.; Fruttiger M.; Lohoff M.; Herrmann A.; Yu H.; Weichselbaum R.; Uckert W.; Huebner N.; Gerhardt H.; Beule D.; Schreiber H.; Blankenstein T.
Tumour ischaemia by interferon-{gamma} resembles physiological blood vessel regression
Nature : (2017-04-26)



Maatz H.; Kolinski M.; Hubner N.; Landthaler M.
Transcriptome-wide identification of RNA-binding protein binding sites using photoactivatable-ribonucleoside-enhanced crosslinking immunoprecipitation (PAR-CLIP)
Current Protocols in Molecular Biology 118: 27.6.1-27.6.19 (2017-04-03)



Coan P.M.; Hummel O.; Diaz A.I.G.; Barrier M.; Alfazema N.; Norsworthy P.J.; Pravenec M.; Petretto E.; Huebner N.; Aitman T.J.
Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat
Disease Models & Mechanisms 10 (3): 297-306 (2017-03-01)



McDermott-Roe C.; Leleu M.; Rowe G.C.; Palygin O.; Bukowy J.D.; Kuo J.; Rech M.; Hermans-Beijnsberger S.; Schaefer S.; Adami E.; Creemers E.E.; Heinig M.; Schroen B.; Arany Z.; Petretto E.; Geurts A.M.
Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function
PLoS ONE 12 (2): e0170458 (2017-02-03)



Jaerve A.; Muehlstedt S.; Qadri F.; Nickl B.; Schulz H.; Huebner N.; Oezcelik C.; Bader M.
Adverse left ventricular remodeling by glycoprotein nonmetastatic melanoma protein B in myocardial infarction
FASEB Journal 31 (2): 556-568 (2017-02)



Middelkamp S.; van Heesch S.; Braat A.K.; de Ligt J.; van Iterson M.; Simonis M.; van Roosmalen M.J.; Kelder M.J.E.; Kruisselbrink E.; Hochstenbach R.; Verbeek N.E.; Ippel E.F.; Adolfs Y.; Pasterkamp R.J.; Kloosterman W.P.; Kuijk E.W.; Cuppen E.
Molecular dissection of germline chromothripsis in a developmental context using patient-derived iPS cells
Genome Medicine 9 (1): 9 (2017-01-26)



Lorenz C.; Lesimple P.; Bukowiecki R.; Zink A.; Inak G.; Mlody B.; Singh M.; Semtner M.; Mah N.; Aure K.; Leong M.; Zabiegalov O.; Lyras E.M.; Pfiffer V.; Fauler B.; Eichhorst J.; Wiesner B.; Huebner N.; Priller J.; Mielke T.; Meierhofer D.; Izsvak Z.; Meier J.C.; Bouillaud F.; Adjaye J.; Schuelke M.; Wanker E.E.; Lombes A.; Prigione A.
Human iPSC-derived neural progenitors are an effective drug discovery model for neurological mtDNA disorders
Cell Stem Cell : (2017-01-26)



Schafer S.; de Marvao A.; Adami E.; Fiedler L.R.; Ng B.; Khin E.; Rackham O.J.L.; van Heesch S.; Pua C.J.; Kui M.; Walsh R.; Tayal U.; Prasad S.K.; Dawes T.J.W.; Ko N.S.J.; Sim D.; Chan L.L.H.; Chin C.W.L.; Mazzarotto F.; Barton P.J.; Kreuchwig F.; de Kleijn D.P.V.; Totman T.; Biffi C.; Tee N.; Rueckert D.; Schneider V.; Faber A.; Regitz-Zagrosek V.; Seidman J.G.; Seidman C.E.; Linke W.A.; Kovalik J.P.; O'Regan D.; Ware J.S.; Hubner N.; Cook S.A.
Titin-truncating variants affect heart function in disease cohorts and the general population
Nature Genetics 49 (1): 46-53 (2017-01)



2016

Maatz H.; van Heesch S.; Kreuchwig F.; Faber A.; Adami E.; Hubner N.; Heinig M.
Epigenetics and control of RNAs
Methods in Molecular Biology 1488: 217-237 (2016-12-09)



Seemanova E.; Varon R.; Vejvalka J.; Jarolim P.; Seeman P.; Chrzanowska K.H.; Digweed M.; Resnick I.; Kremensky I.; Saar K.; Hoffmann K.; Dutrannoy V.; Karbasiyan M.; Ghani M.; Baric I.; Tekin M.; Kovacs P.; Krawczak M.; Reis A.; Sperling K.; Nothnagel M.
The Slavic NBN founder mutation: a role for reproductive fitness?
PLoS ONE 11 (12): e0167984 (2016-12-09)



Beqqali A.; Bollen I.A.E.; Rasmussen T.B.; van den Hoogenhof M.M.; van Deutekom H.W.M.; Schafer S.; Haas J.; Meder B.; Sorensen K.E.; van Oort R.J.; Mogensen J.; Hubner N.; Creemers E.E.; van der Velden J.; Pinto Y.M.
A mutation in the glutamate-rich region of RBM20 causes dilated cardiomyopathy through missplicing of titin and impaired Frank-Starling mechanism
Cardiovascular Research 112 (1): 452-463 (2016-10-01)



van der Harst P.; van Setten J.; Verweij N.; Vogler G.; Franke L.; Maurano M.T.; Wang X.; Mateo Leach I.; Eijgelsheim M.; Sotoodehnia N.; Hayward C.; Sorice R.; Meirelles O.; Lyytikaeinen L.P.; Polasek O.; Tanaka T.; Arking D.E.; Ulivi S.; Trompet S.; Mueller-Nurasyid M.; Smith A.V.; Doerr M.; Kerr K.F.; Magnani J.W.; Del Greco M F.; Zhang W.; Nolte I.M.; Silva C.T.; Padmanabhan S.; Tragante V.; Esko T.; Abecasis G.R.; Adriaens M.E.; Andersen K.; Barnett P.; Bis J.C.; Bodmer R.; Buckley B.M.; Campbell H.; Cannon M.V.; Chakravarti A.; Chen L.Y.; Delitala A.; Devereux R.B.; Doevendans P.A.; Dominiczak A.F.; Ferrucci L.; Ford I.; Gieger C.; Harris T.B.; Haugen E.; Heinig M.; Hernandez D.G.; Hillege H.L.; Hirschhorn J.N.; Hofman A.; Hubner N.; Hwang S.J.; Iorio A.; Kaehoenen M.; Kellis M.; Kolcic I.; Kooner Is.K.; Kooner J.S.; Kors J.A.; Lakatta E.G.; Lage K.; Launer L.J.; Levy D.; Lundby A.; Macfarlane P.W.; May D.; Meitinger T.; Metspalu A.; Nappo S.; Naitza S.; Neph S.; Nord A.S.; Nutile T.; Okin P.M.; Olsen J.V.; Oostra B.A.; Penninger J.M.; Pennacchio L.A.; Pers T.H.; Perz S.; Peters A.; Pinto Y.M.; Pfeufer A.; Pilia M.G.; Pramstaller P.P.; Prins B.P.; Raitakari O.T.; Raychaudhuri S.; Rice K.M.; Rossin E.J.; Rotter J.I.; Schaefer S.; Schlessinger D.; Schmidt C.O.; Sehmi J.; Sillje H.H.W.; Sinagra G.; Sinner M.F.; Slowikowski K.; Soliman E.Z.; Spector T.D.; Spiering W.; Stamatoyannopoulos J.A.; Stolk R.P.; Strauch K.; Tan S.T.; Tarasov K.V.; Trinh B.; Uitterlinden A.G.; van den Boogaard M.; van Duijn C.M.; van Gilst W.H.; Viikari J.S.; Visscher P.M.; Vitart V.; Voelker U.; Waldenberger M.; Weichenberger C.X.; Westra H.J.; Wijmenga C.; Wolffenbuttel B.H.; Yang J.; Bezzina C.R.; Munroe P.B.; Snieder H.; Wright A.F.; Rudan I.; Boyer L.A.; Asselbergs F.W.; van Veldhuisen D.J.; Stricker B.H.; Psaty B.M.; Ciullo M.; Sanna S.; Lehtimaeki T.; Wilson J.F.; Bandinelli S.; Alonso A.; Gasparini P.; Jukema J.W.; Kaeaeb S.; Gudnason V.; Felix S.B.; Heckbert S.R.; de Boer R.A.; Newton-Cheh C.; Hicks A.A.; Chambers J.C.; Jamshidi Y.; Visel A.; Christoffels V.M.; Isaacs A.; Samani N.J.; de Bakker P.I.W.
52 genetic loci influencing myocardial mass
Journal of the American College of Cardiology 68 (13): 1435-1448 (2016-09-27)



Magarin M.; Schulz H.; Thierfelder L.; Drenckhahn J.D.
Transcriptional profiling of regenerating embryonic mouse hearts
Genomics Data 9: 145-147 (2016-09)



Runge C.L.; Indap A.; Zhou Y.; Kent J.W.; King E.; Erbe C.B.; Cole R.; Littrell J.; Merath K.; James R.; Rueschendorf F.; Kerschner J.E.; Marth G.; Huebner N.; Goering H.H.H.; Friedland D.R.; Kwok W.M.; Olivier M.
Association of TMTC2 with human nonsyndromic sensorineural hearing loss
JAMA Otolaryngology Head & Neck Surgery 142 (9): 866-872 (2016-09-01)



Magarin M.; Pohl T.; Lill A.; Schulz H.; Blaschke F.; Heuser A.; Thierfelder L.; Donath S.; Drenckhahn J.D.
Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress
Journal of Molecular and Cellular Cardiology 97: 1-14 (2016-08)



Mannhardt I.; Breckwoldt K.; Letuffe-Breniere D.; Schaaf S.; Schulz H.; Neuber C.; Benzin A.; Werner T.; Eder A.; Schulze T.; Klampe B.; Christ T.; Hirt M.N.; Huebner N.; Moretti A.; Eschenhagen T.; Hansen A.
Human engineered heart tissue: analysis of contractile force
Stem Cell Reports 7 (1): 29-42 (2016-07-12)



Wang M.; Sips P.; Khin E.; Rotival M.; Sun X.; Ahmed R.; Widjaja A.A.; Schafer S.; Yusoff P.; Choksi Pe.K.; Ko N.S.J.; Singh M.K.; Epstein D.; Guan Y.; Houstek J.; Mracek T.; Nuskova H.; Mikell B.; Tan J.; Pesce F.; Kolar F.; Bottolo L.; Mancini M.; Hubner N.; Pravenec M.; Petretto E.; MacRae C.; Cook S.A.
Wars2 is a determinant of angiogenesis
Nature Communications 7: 12061 (2016-07-08)



Brachs M.; Wiegand S.; Leupelt V.; Ernert A.; Kintscher U.; Jumpertz von Schwarzenberg R.; Decker A.M.; Bobbert T.; Huebner N.; Chen W.; Krude H.; Spranger J.; Mai K.
ANP system activity predicts variability of fat mass reduction and insulin sensitivity during weight loss
Metabolism 65 (6): 935-943 (2016-06)



Abdelmagid N.; Bereczky-Veress B.; Atanur S.; Musilova A.; Zidek V.; Saba L.; Warnecke A.; Khademi M.; Studahl M.; Aurelius E.; Hjalmarsson A.; Garcia-Diaz A.; Denis C.V.; Bergstroem T.; Skoeldenberg B.; Kockum I.; Aitman T.; Huebner N.; Olsson T.; Pravenec M.; Diez M.
Von Willebrand factor gene variants associate with herpes simplex encephalitis
PLoS ONE 11 (5): e0155832 (2016-05-25)



de Oliveira K.A.P.; Kaergel E.; Heinig M.; Fontaine J.F.; Patone G.; Muro E.M.; Mathas S.; Hummel M.; Andrade-Navarro M.A.; Huebner N.; Scheidereit C.
A roadmap of constitutive NF-{kappa}B activity in Hodgkin lymphoma: dominant roles of p50 and p52 revealed by genome-wide analyses
Genome Medicine 8 (1): 28 (2016-03-17)



Kannan S.; Nicola Z.; Overall R.W.; Ichwan M.; Ramirez-Rodriguez G.; Grzyb A.; Patone G.; Saar K.; Huebner N.; Kempermann G.
Systems genetics analysis of a recombinant inbred mouse cell culture panel reveals Wnt pathway member Lrp6 as a regulator of adult hippocampal precursor cell proliferation
Stem Cells 34 (3): 674-684 (2016-03)



Rubattu S.; Di Castro S.; Schulz H.; Geurts A.M.; Cotugno M.; Bianchi F.; Maatz H.; Hummel O.; Falak S.; Stanzione R.; Marchitti S.; Scarpino S.; Giusti B.; Kura A.; Gensini G.F.; Peyvandi F.; Mannucci P.M.; Rasura M.; Sciarretta S.; Dwinell M.R.; Hubner N.; Volpe M.
Ndufc2 gene inhibition is associated with mitochondrial dysfunction and increased stroke susceptibility in an animal model of complex human disease
Journal of the American Heart Association 5 (2): e00270 (2016-02-17)



Creemers E.E.; Bawazeer A.; Ugalde A.P.; van Deutekom H.W.M.; van der Made I.; de Groot N.E.; Adriaens M.E.; Cook S.A.; Bezzina C.R.; Hubner N.; van der Velden J.; Elkon R.; Agami R.; Pinto Y.M.
Genome-wide polyadenylation maps reveal dynamic mRNA 3'-end formation in the failing human heart
Circulation Research 118 (3): 433-438 (2016-02-05)



Stenzig J.; Hirt M.N.; Loeser A.; Bartholdt L.M.; Hensel J.T.; Werner T.R.; Riemenschneider M.; Indenbirken D.; Guenther T.; Mueller C.; Huebner N.; Stoll M.; Eschenhagen T.
DNA methylation in an engineered heart tissue model of cardiac hypertrophy: common signatures and effects of DNA methylation inhibitors
Basic Research in Cardiology 111 (1): 9 (2016-01)



2015

Paternoster L.; Standl M.; Waage J.; Baurecht H.; Hotze M.; Strachan D.P.; Curtin J.A.; Bonnelykke K.; Tian C.; Takahashi A.; Esparza-Gordillo J.; Alves A.C.; Thyssen J.P.; den Dekker H.T.; Ferreira M.A.; Altmaier E.; Sleiman P.M.A.; Xiao F.L.; Gonzalez J.R.; Marenholz I.; Kalb B.; Pino-Yanes M.; Xu C.J.; Carstensen L.; Groen-Blokhuis M.M.; Venturini C.; Pennell C.E.; Barton S.J.; Levin A.M.; Curjuric I.; Bustamante M.; Kreiner-Moller E.; Lockett G.A.; Bacelis J.; Bunyavanich S.; Myers R.A.; Matanovic A.; Kumar A.; Tung J.Y.; Hirota T.; Kubo M.; McArdle W.L.; Henderson A.J.; Kemp J.P.; Zheng J.; Smith G.D.; Rueschendorf F.; Bauerfeind A.; Lee-Kirsch M.A.; Arnold A.; Homuth G.; Schmidt C.O.; Mangold E.; Cichon S.; Keil T.; Rodriguez E.; Peters A.; Franke A.; Lieb W.; Novak N.; Foelster-Holst R.; Horikoshi M.; Pekkanen J.; Sebert S.; Husemoen L.L.; Grarup N.; de Jongste J.C.; Rivadeneira F.; Hofman A.; Jaddoe V.W.V.; Pasmans S.G.M.A.; Elbert N.J.; Uitterlinden A.G.; Marks G.B.; Thompson P.J.; Matheson M.C.; Robertson C.F.; Ried J.S.; Li J.; Zuo X.B.; Zheng X.D.; Yin X.Y.; Sun L.D.; McAleer M.A.; O'Regan G.M.; Fahy C.M.R.; Campbell L.E.; Macek M.; Kurek M.; Hu D.; Eng C.; Postma D.S.; Feenstra B.; Geller F.; Hottenga J.J.; Middeldorp C.M.; Hysi P.; Bataille V.; Spector T.; Tiesler C.M.T.; Thiering E.; Pahukasahasram B.; Yang J.J.; Imboden M.; Huntsman S.; Vilor-Tejedor N.; Relton C.L.; Myhre R.; Nystad W.; Custovic A.; Weiss S.T.; Meyers D.A.; Soederhaell C.; Melen E.; Ober C.; Raby B.A.; Simpson A.; Jacobsson B.; Holloway J.W.; Bisgaard H.; Sunyer J.; Probst-Hensch N.M.; Williams L.K.; Godfrey K.M.; Wang C.A.; Boomsma D.I.; Melbye M.; Koppelman G.H.; Jarvis D.; McLean W.H.I.; Irvine A.D.; Zhang X.J.; Hakonarson H.; Gieger C.; Burchard E.G.; Martin N.G.; Duijts L.; Linneberg A.; Jarvelin M.R.; Noethen M.M.; Lau S.; Huebner N.; Lee Y.A.; Tamari M.; Hinds D.A.; Glass D.; Brown S.J.; Heinrich J.; Evans D.M.; Weidinger S.
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
Nature Genetics 47 (12): 1449-1456 (2015-12)



Marenholz I.; Esparza-Gordillo J.; Rueschendorf F.; Bauerfeind A.; Strachan D.P.; Spycher B.D.; Baurecht H.; Margaritte-Jeannin P.; Saeaef A.; Kerkhof M.; Ege M.; Baltic S.; Matheson M.C.; Li J.; Michel S.; Ang W.Q.; McArdle W.; Arnold A.; Homuth G.; Demenais F.; Bouzigon E.; Soederhaell C.; Pershagen G.; de Jongste J.C.; Postma D.S.; Braun-Fahrlaender C.; Horak E.; Ogorodova L.M.; Puzyrev V.P.; Bragina E.Y.; Hudson T.J.; Morin C.; Duffy D.L.; Marks G.B.; Robertson C.F.; Montgomery G.W.; Musk B.; Thompson P.J.; Martin N.G.; James A.; Sleiman P.; Toskala E.; Rodriguez E.; Foelster-Holst R.; Franke A.; Lieb W.; Gieger C.; Heinzmann A.; Rietschel E.; Keil T.; Cichon S.; Noethen M.M.; Pennell C.E.; Sly P.D.; Schmidt C.O.; Matanovic A.; Schneider V.; Heinig M.; Huebner N.; Holt P.G.; Lau S.; Kabesch M.; Weidinger S.; Hakonarson H.; Ferreira M.A.R.; Laprise C.; Freidin M.B.; Genuneit J.; Koppelman G.H.; Melen E.; Dizier M.H.; Henderson A.J.; Lee Y.A.
Meta-analysis identifies seven susceptibility loci involved in the atopic march
Nature Communications 6: 8804 (2015-11-06)



Binger K.J.; Gebhardt M.; Heinig M.; Rintisch C.; Schroeder A.; Neuhofer W.; Hilgers K.; Manzel A.; Schwartz C.; Kleinewietfeld M.; Voelkl J.; Schatz V.; Linker R.A.; Lang F.; Voehringer D.; Wright M.D.; Hubner N.; Dechend R.; Jantsch J.; Titze J.; Mueller D.N.
High salt reduces the activation of IL-4- and IL-13-stimulated macrophages
Journal of Clinical Investigation 125 (11): 4223-4238 (2015-11-02)



Lindblom R.P.F.; Berg A.; Stroem M.; Aeinehband S.; Dominguez C.A.; Al Nimer F.; Abdelmagid N.; Heinig M.; Zelano J.; Harnesk K.; Huebner N.; Nilsson B.; Ekdahl K.N.; Diez M.; Cullheim S.; Piehl F.
Complement receptor 2 is up regulated in the spinal cord following nerve root injury and modulates the spinal cord response
Journal of Neuroinflammation 12: 192 (2015-10-26)



Schafer S.; Miao K.; Benson C.C.; Heinig M.; Cook S.A.; Hubner N.
Alternative splicing signatures in RNA-seq data: percent spliced in (PSI)
Current Protocols in Human Genetics 87: 11.16.1-11.16.14 (2015-10-06)



Albert G.I.; Schell C.; Kirschner K.M.; Schaefer S.; Naumann R.; Mueller A.; Kretz O.; Kuropka B.; Girbig M.; Huebner N.; Krause E.; Scholz H.; Huber T.B.; Knobeloch K.P.; Freund C.
The GYF domain protein CD2BP2 is critical for embryogenesis and podocyte function
Journal of Molecular Cell Biology 7 (5): 402-414 (2015-10)



Buyandelger B.; Mansfield C.; Kostin S.; Choi O.; Roberts A.M.; Ware J.S.; Mazzarotto F.; Pesce F.; Buchan R.; Isaacson R.L.; Vouffo J.; Gunkel S.; Knoell G.; McSweeney S.J.; Wei H.; Perrot A.; Pfeiffer C.; Toliat M.R.; Ilieva K.; Krysztofinska E.; Lopez-Olaneta M.M.; Gomez-Salinero J.M.; Schmidt A.; Ng K.E.; Teucher N.; Chen J.; Teichmann M.; Eilers M.; Haverkamp W.; Regitz-Zagrosek V.; Hasenfuss G.; Braun T.; Pennell D.J.; Gould I.; Barton P.J.R.; Lara-Pezzi E.; Schafer S.; Huebner N.; Felkin L.E.; O'Regan D.P.; Petretto E.; Brand T.; Milting H.; Nuernberg P.; Schneider M.D.; Prasad S.; Knoell R.
ZBTB17 (MIZ1) is important for the cardiac stress response and a novel candidate gene for cardiomyopathy and heart failure
Circulation Cardiovascular Genetics 8 (5): 643-652 (2015-10)



Herlan L.; Schulz A.; Schulte L.; Schulz H.; Huebner N.; Kreutz R.
Novel candidate genes for impaired nephron development in a rat model with inherited nephron deficit and albuminuria
Clinical and Experimental Pharmacology and Physiology 42 (10): 1051-1058 (2015-10)



Jost K.L.; Bertulat B.; Rapp A.; Brero A.; Hardt T.; Domaing P.; Goesele C.; Schulz H.; Huebner N.; Cardoso M.C.
Gene repositioning within the cell nucleus is not random and is determined by its genomic neighborhood
Epigenetics & Chromatin 8: 36 (2015-09-17)



Schaarschmidt H.; Ellinghaus D.; Rodriguez E.; Kretschmer A.; Baurecht H.; Lipinski S.; Meyer-Hoffert U.; Harder J.; Lieb W.; Novak N.; Foelster-Holst R.; Esparza-Gordillo J.; Marenholz I.; Ruschendorf F.; Hubner N.; Reischl E.; Waldenberger M.; Gieger C.; Illig T.; Kabesch M.; Zhang X.J.; Xiao F.L.; Lee Y.A.; Franke A.; Weidinger S.
A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis
Journal of Allergy and Clinical Immunology 136 (3): 802-806 (2015-09)



Hinson J.T.; Chopra A.; Nafissi N.; Polacheck W.J.; Benson C.C.; Swist S.; Gorham J.; Yang L.; Schafer S.; Sheng C.C.; Haghighi A.; Homsy J.; Hubner N.; Church G.; Cook S.A.; Linke W.A.; Chen C.S.; Seidman J.G.; Seidman C.E.
Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy
Science 349 (6251): 982-986 (2015-08-28)



Lefebvre J.; Clarkson M.; Massa F.; Bradford S.T.; Charlet A.; Buske F.; Lacas-Gervais S.; Schulz H.; Gimpel C.; Hata Y.; Schaefer F.; Schedl A.
Alternatively spliced isoforms of WT1 control podocyte-specific gene expression
Kidney International 88 (2): 321-331 (2015-08)



Budde B.S.; Mizumoto S.; Kogawa R.; Becker C.; Altmueller J.; Thiele H.; Rueschendorf F.; Toliat M.R.; Kaleschke G.; Haemmerle J.M.; Hoehne W.; Sugahara K.; Nuernberg P.; Kennerknecht I.
Skeletal dysplasia in a consanguineous clan from the island of Nias/Indonesia is caused by a novel mutation in B3GAT3
Human Genetics 134 (7): 691-704 (2015-07)



Lim H.W.; Uhlenhaut N.H.; Rauch A.; Weiner J.; Huebner S.; Huebner N.; Won K.J.; Lazar M.A.; Tuckermann J.; Steger D.J.
Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo
Genome Research 25 (6): 836-844 (2015-06)



Maass P.G.; Aydin A.; Luft F.C.; Schaechterle C.; Weise A.; Stricker S.; Lindschau C.; Vaegler M.; Qadri F.; Toka H.R.; Schulz H.; Krawitz P.M.; Parkhomchuk D.; Hecht J.; Hollfinger I.; Wefeld-Neuenfeld Y.; Bartels-Klein E.; Muehl A.; Kann M.; Schuster H.; Chitayat D.; Bialer M.G.; Wienker T.F.; Ott J.; Rittscher K.; Liehr T.; Jordan J.; Plessis G.; Tank J.; Mai K.; Naraghi R.; Hodge R.; Hopp M.; Hattenbach L.O.; Busjahn A.; Rauch A.; Vandeput F.; Gong M.; Rueschendorf F.; Huebner N.; Haller H.; Mundlos S.; Bilginturan N.; Movsesian M.A.; Klussmann E.; Toka O.; Baehring S.
PDE3A mutations cause autosomal dominant hypertension with brachydactyly
Nature Genetics 47 (6): 647-653 (2015-06)



Schafer S.; Adami E.; Heinig M.; Costa Rodrigues K.E.; Kreuchwig F.; Silhavy J.; van Heesch S.; Simaite D.; Rajewsky N.; Cuppen E.; Pravenec M.; Vingron M.; Cook S.A.; Hubner N.
Translational regulation shapes the molecular landscape of complex disease phenotypes
Nature Communications 6: 7200 (2015-05-26)



Hosp F.; Vossfeldt H.; Heinig M.; Vasiljevic D.; Arumughan A.; Wyler E.; Landthaler M.; Hubner N.; Wanker E.E.; Lannfelt L.; Ingelsson M.; Lalowski M.; Voigt A.; Selbach M.
Quantitative interaction proteomics of neurodegenerative disease proteins
Cell Reports 11 (7): 1134-1146 (2015-05-19)



Hermsen R.; de Ligt J.; Spee W.; Blokzijl F.; Schaefer S.; Adami E.; Boymans S.; Flink S; van Boxtel R.; van der Weide R.H.; Aitman T.; Huebner N.; Simonis M.; Tabakoff B.; Guryev V.; Cuppen E.
Genomic landscape of rat strain and substrain variation
BMC Genomics 16: 357 (2015-05-06)



Wehland M.; Aleshcheva G.; Schulz H.; Saar K.; Huebner N.; Hemmersbach R.; Braun M.; Ma X.; Frett T.; Warnke E.; Riwaldt S.; Pietsch J.; Corydon T.J.; Infanger M.; Grimm D.
Differential gene expression of human chondrocytes cultured under short-term altered gravity conditions during parabolic flight maneuvers
Cell Communication and Signaling 13 (1): 18 (2015-03-20)



Esparza-Gordillo J.; Matanovic A.; Marenholz I.; Bauerfeind A.; Rohde K.; Nemat K.; Lee-Kirsch M.A.; Nordenskjoeld M.; Winge M.C.G.; Keil T.; Krueger R.; Lau S.; Beyer K.; Kalb B.; Niggemann B.; Huebner N.; Cordell H.J.; Bradley M.; Lee Y.A.
Maternal filaggrin mutations increase the risk of atopic dermatitis in children: an effect independent of mutation inheritance
PLoS Genetics 11 (3): e1005076 (2015-03-10)



Heinig M.; Colome-Tatche M.; Taudt A.; Rintisch C.; Schafer S.; Pravenec M.; Hubner N.; Vingron M.; Johannes F.
histoneHMM: Differential analysis of histone modifications with broad genomic footprints
BMC Bioinformatics 16: 60 (2015-02-22)



Samanas N.B.; Commers T.W.; Dennison K.L.; Harenda Q.E.; Kurz S.G.; Lachel C.M.; Wavrin K.L.; Bowler M.; Nijman I.J.; Guryev V.; Cuppen E.; Hubner N.; Sullivan R.; Vezina C.M.; Shull J.D.
Genetic etiology of renal agenesis: fine mapping of renag1 and identification of Kit as the candidate functional gene
PLoS ONE 10 (2): e0118147 (2015-02-18)



Maatz H.; Heinig M.; Huebner N.
Alternatives Spleissen im Herzen [Alternative splicing in the heart]
BIOspektrum 21 (1): 53-56 (2015-02)



Roberts A.M.; Ware J.S.; Herman D.S.; Schafer S.; Baksi J.; Bick A.G.; Buchan R.J.; Walsh R.; John S.; Wilkinson S.; Mazzarotto F.; Felkin L.E.; Gong S.; MacArthur J.A.L.; Cunningham F.; Flannick J.; Gabriel S.B.; Altshuler D.M.; Macdonald P.S.; Heinig M.; Keogh A.M.; Hayward C.S.; Banner N.R.; Pennell D.J.; O'Regan D.P.; San T.R.; de Marvao A.; Dawes T.J.W.; Gulati A.; Birks E.J.; Yacoub M.H.; Radke M.; Gotthardt M.; Wilson J.G.; O'Donnell C.J.; Prasad S.K.; Barton P.J.R.; Fatkin D.; Hubner N.; Seidman J.G.; Seidman C.E.; Cook S.A.
Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease
Science Translational Medicine 7 (270): 270ra6 (2015-01-14)



Baurecht H.; Hotze M.; Brand S.; Buening C.; Cormican P.; Corvin A.; Ellinghaus D.; Ellinghaus E.; Esparza-Gordillo J.; Foelster-Holst R.; Franke A.; Gieger C.; Hubner N.; Illig T.; Irvine A.D.; Kabesch M.; Lee Y.A.E.; Lieb W.; Marenholz I.; McLean W.H.I.; Morris D.W.; Mrowietz U.; Nair R.; Noethen M.M.; Novak N.; O'Regan G.M.; Schreiber S.; Smith C.; Strauch K.; Stuart P.E.; Trembath R.; Tsoi L.C.; Weichenthal M.; Barker J.; Elder J.T.; Weidinger S.; Cordell H.J.; Brown S.J.
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms
American Journal of Human Genetics 96 (1): 104-120 (2015-01-08)



Guenther C.; Kind B.; Reijns M.A.M.; Berndt N.; Martinez-Bueno M.; Wolf C.; Tuengler V.; Chara O.; Lee Y.A.; Huebner N.; Bicknell L.; Blum S.; Krug C.; Schmidt F.; Kretschmer S.; Koss S.; Astell K.R.; Ramantani G.; Bauerfeind A.; Morris D.L.; Cunninghame Graham D.S.; Bubeck D.; Leitch A.; Ralston S.H.; Blackburn E.A.; Gahr M.; Witte T.; Vyse T.J.; Melchers I.; Mangold E.; Noethen M.M.; Aringer M.; Kuhn A.; Luethke K.; Unger L.; Bley A.; Lorenzi A.; Isaacs J.D.; Alexopoulou D.; Conrad K.; Dahl A.; Roers A.; Alarcon-Riquelme M.E.; Jackson A.P.; Lee-Kirsch M.A.
Defective removal of ribonucleotides from DNA promotes systemic autoimmunity
Journal of Clinical Investigation 125 (1): 413-424 (2015-01-02)



2014

Schlossarek S.; Singh S.; Geertz B.; Schulz H.; Reischmann S.; Huebner N.; Carrier L.
Proteasome inhibition slightly improves cardiac function in mice with hypertrophic cardiomyopathy
Frontiers in Physiology 5: 484 (2014-12-16)



Schubert J.; Siekierska A.; Langlois M.; May P.; Huneau C.; Becker F.; Muhle H.; Suls A.; Lemke J.R.; de Kovel C.G.F.; Thiele H.; Konrad K.; Kawalia A.; Toliat M.R.; Sander T.; Rueschendorf F.; Caliebe A.; Nagel I.; Kohl B.; Kecskes A.; Jacmin M.; Hardies K.; Weckhuysen S.; Riesch E.; Dorn T.; Brilstra E.H.; Baulac S.; Moller R.S.; Hjalgrim H.; Koeleman B.P.C.; Jurkat-Rott K.; Lehman-Horn F.; Roach J.C.; Glusman G.; Hood L.; Galas D.J.; Martin B.; de Witte P.A.M.; Biskup S.; De Jonghe P.; Helbig I.; Balling R.; Nuernberg P.; Crawford A.D.; Esguerra C.V.; Weber Y.G.; Lerche H.
Mutations in STX1B, encoding a presynaptic protein, cause fever-associated epilepsy syndromes
Nature Genetics 46 (12): 1327-1332 (2014-12)



Simaite D.; Kofent J.; Gong M.; Rueschendorf F.; Jia S.; Arn P.; Bentler K.; Ellaway C.; Kuehnen P.; Hoffmann G.F.; Blau N.; Spagnoli F.M.; Huebner N.; Raile K.
Recessive mutations in PCBD1 cause a new type of early-onset diabetes
Diabetes 63 (10): 3557-3564 (2014-10)



Hirt M.N.; Boeddinghaus J.; Mitchell A.; Schaaf S.; Boernchen C.; Mueller C.; Schulz H.; Hubner N.; Stenzig J.; Stoehr A.; Neuber C.; Eder A.; Luther P.K.; Hansen A.; Eschenhagen T.
Functional improvement and maturation of rat and human engineered heart tissue by chronic electrical stimulation
Journal of Molecular and Cellular Cardiology 74: 151-161 (2014-09)



Mojallal M.; Zheng Y.; Hultin S.; Audebert S.; van Harn T.; Johnsson P.; Lenander C.; Fritz N.; Mieth C.; Corcoran M.; Lembo F.; Hallstroem M.; Hartman J.; Mazure N.M.; Weide T.; Grander D.; Borg J.P.; Uhlen P.; Holmgren L.
AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion
Nature Communications 5: 4557 (2014-08-01)



Maatz H.; Jens M.; Liss M.; Schafer S.; Heinig M.; Kirchner M.; Adami E.; Rintisch C.; Dauksaite V.; Radke M.H.; Selbach M.; Barton P.J.R.; Cook S.A.; Rajewsky N.; Gotthardt M.; Landthaler M.; Hubner N.
RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing
Journal of Clinical Investigation 124 (8): 3419-3430 (2014-08-01)



Motamedi F.J.; Badro D.A.; Clarkson M.; Rita Lecca M.; Bradford S.T.; Buske F.A.; Saar K.; Huebner N.; Braendli A.W.; Schedl A.
WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors
Nature Communications 5: 4444 (2014-07-17)



Falak S.; Schafer S.; Baud A.; Hummel O.; Schulz H.; Gauguier D.; Hubner N.; Osborne-Pellegrin M.
Protease inhibitor 15, a candidate gene for abdominal aortic internal elastic lamina ruptures in the rat
Physiological Genomics 46 (12): 418-428 (2014-06-15)



Rintisch C.; Heinig M.; Bauerfeind A.; Schafer S.; Mieth C.; Patone G.; Hummel O.; Chen W.; Cook S.; Cuppen E.; Colome-Tatche M.; Johannes F.; Jansen R.C.; Neil H.; Werner M.; Pravenec M.; Vingron M.; Hubner N.
Natural variation of histone modification and its impact on gene expression in the rat genome
Genome Research 24 (6): 942-953 (2014-06)



Auer F.; Rueschendorf F.; Gombert M.; Husemann P.; Ginzel S.; Izraeli S.; Harit M.; Weintraub M.; Weinstein O.Y.; Lerer I.; Stepensky P.; Borkhardt A.; Hauer J.
Inherited susceptibility to pre B-ALL caused by germline transmission of PAX5 c.547G>A
Leukemia 28 (5): 1136-1138 (2014-05)



Aksoy I.; Giudice V.; Delahaye E.; Wianny F.; Aubry M.; Mure M.; Chen J.; Jauch R.; Bogu G.K.; Nolden T.; Himmelbauer H.; Doss M.X.; Sachinidis A.; Schulz H.; Hummel O.; Martinelli P.; Huebner N.; Stanton L.W.; Real F.X.; Bourillot P.Y.; Savatier P.
Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells
Nature Communications 5: 3719 (2014-04-28)



Ferdaus M.Z.; Xiao B.; Ohara H.; Nemoto K.; Harada Y.; Saar K.; Huebner N.; Isomura M.; Nabika T.
Identification of Stim1 as a candidate gene for exaggerated sympathetic response to stress in the stroke-prone spontaneously hypertensive rat
PLoS ONE 9 (4): e95091 (2014-04-15)



Silhavy J.; Zídek V.; Landa V.; Simakova M.; Mlejnek P.; Skop V.; Oliyarnyk O.; Kazdova L.; Mancini M.; Saar K.; Schulz H.; Huebner N.; Kurtz T.W.; Pravenec M.
Rosuvastatin can block pro-inflammatory actions of transgenic human CRP without reducing its circulating levels
Cardiovascular Therapeutics 32 (2): 59-65 (2014-04)



Langhans C.; Weber-Carstens S.; Schmidt F.; Hamati J.; Kny M.; Zhu X.; Wollersheim T.; Koch S.; Krebs M.; Schulz H.; Lodka D.; Saar K.; Labeit S.; Spies C.; Hubner N.; Spranger J.; Spuler S.; Boschmann M.; Dittmar G.; Butler-Browne G.; Mouly V.; Fielitz J.
Inflammation-induced acute phase response in skeletal muscle and critical illness myopathy
PLoS ONE 9 (3): e92048 (2014-03-20)



Ragancokova D.; Rocca E.; Oonk A.M.M.; Schulz H.; Rohde E.; Bednarsch J.; Feenstra I.; Pennings R.J.E.; Wende H.; Garratt A.N.
TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction
Journal of Clinical Investigation 124 (3): 1214-1227 (2014-03-03)



Chauveau C.; Bonnemann C.G.; Julien C.; Kho A.L.; Marks H.; Talim B.; Maury P.; Arne-Bes M.C.; Uro-Coste E.; Alexandrovich A.; Vihola A.; Schafer S.; Kaufmann B.; Medne L.; Huebner N.; Foley A.R.; Santi M.; Udd B.; Topaloglu H.; Moore S.A.; Gotthardt M.; Samuels M.E.; Gautel M.; Ferreiro A.
Recessive TTN truncating mutations define novel forms of core myopathy with heart disease
Human Molecular Genetics 23 (4): 980-991 (2014-02-15)



Lindblom R.P.F.; Stroem M.; Heinig M.; Al Nimer F.; Aeinehband S.; Berg A.; Dominguez C.A.; Vijayaraghavan S.; Zhang X.M.; Harnesk K.; Zelano J.; Huebner N.; Cullheim S.; Darreh-Shori T.; Diez M.; Piehl F.
Unbiased expression mapping identifies a link between the complement and cholinergic systems in the rat central nervous system
Journal of Immunology 192 (3): 1138-1153 (2014-02-01)



Ma X.; Pietsch J.; Wehland M.; Schulz H.; Saar K.; Huebner N.; Bauer J.; Braun M.; Schwarzwaelder A.; Segerer J.; Birlem M.; Horn A.; Hemmersbach R.; Wasser K.; Grosse J.; Infanger M.; Grimm D.
Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space
FASEB Journal 28 (2): 813-835 (2014-02)



Brooke M.A.; Longhurst H.J.; Plagnol V.; Kirkby N.S.; Mitchell J.A.; Rueschendorf F.; Warner T.D.; Kelsell D.P.; MacDonald T.T.
Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-{alpha}
Gut 63 (1): 96-104 (2014-01)



2013

Low T.Y.; van Heesch S.; van den Toorn H.; Giansanti P.; Cristobal A.; Toonen P.; Schaefer S.; Huebner N.; van Breukelen B.; Mohammed S.; Cuppen E.; Heck A.J.R.; Guryev V.
Quantitative and qualitative proteome characteristics extracted from in-depth integrated genomics and proteomics analysis
Cell Reports 5 (5): 1469-1478 (2013-12-12)



Pernhorst K.; Herms S.; Hoffmann P.; Cichon S.; Schulz H.; Sander T.; Schoch S.; Becker A.J.; Grote A.
TLR4, ATF-3 and IL8 inflammation mediator expression correlates with seizure frequency in human epileptic brain tissue
Seizure 22 (8): 675-678 (2013-10)



Pakula A.; Schneider J.; Janke J.; Zacharias U.; Schulz H.; Huebner N.; Maehler A.; Spuler A.; Spuler S.; Carlier P.; Boschmann M.
Altered expression of cyclin A 1 in muscle of patients with facioscapulohumeral muscle dystrophy (FSHD-1)
PLoS ONE 8 (9): e73573 (2013-09-03)



Stellzig-Eisenhauer A.; Decker E.; Meyer-Marcotty P.; Rau C.; Fiebig B.S.; Kress W.; Saar K.; Rueschendorf F.; Huebner N.; Grimm T.; Witt E.; Weber B.H.F.
Defaut primaire d'eruption (DPE) : analyse genetique clinique et moleculaire [Primary failure of eruption (PFE): clinical and molecular genetics analysis]
Orthodontie Francaise 84 (3): 241-250 (2013-09)



Esparza-Gordillo J.; Schaarschmidt H.; Liang L.; Cookson W.; Bauerfeind A.; Lee-Kirsch M.A.; Nemat K.; Henderson J.; Paternoster L.; Harper J.L.; Mangold E.; Nothen M.M.; Rueschendorf F.; Kerscher T.; Marenholz I.; Matanovic A.; Lau S.; Keil T.; Bauer C.P.; Kurek M.; Ciechanowicz A.; Macek M.; Franke A.; Kabesch M.; Hubner N.; Abecasis G.; Weidinger S.; Moffatt M.; Lee Y.A.
A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis
Journal of Allergy and Clinical Immunology 132 (2): 371-377 (2013-08)



Atanur S.S.; Diaz A.G.; Maratou K.; Sarkis A.; Rotival M.; Game L.; Tschannen M.R.; Kaisaki P.J.; Otto G.W.; John Ma M.C.; Keane T.M.; Hummel O.; Saar K.; Chen W.; Guryev V.; Gopalakrishnan K.; Garrett M.R.; Joe B.; Citterio L.; Bianchi G.; McBride M.; Dominiczak A.; Adams D.J.; Serikawa T.; Flicek P.; Cuppen E.; Hubner N.; Petretto E.; Gauguier D.; Kwitek A.; Jacob H.; Aitman T.J.
Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat
Cell 154 (3): 691-703 (2013-08-01)



Meder B.; Ruehle F.; Weis T.; Homuth G.; Keller A.; Franke J.; Peil B.; Bermejo J.L.; Frese K.; Huge A.; Witten A.; Vogel B.; Haas J.; Voelker U.; Ernst F.; Teumer A.; Ehlermann P.; Zugck C.; Friedrichs F.; Kroemer H.; Doerr M.; Hoffmann W.; Maisch B.; Pankuweit S.; Ruppert V.; Scheffold T.; Kuehl U.; Schultheiss H.P.; Kreutz R.; Ertl G.; Angermann C.; Charron P.; Villard E.; Gary F.; Isnard R.; Komajda M.; Lutz M.; Meitinger T.; Sinner M.F.; Wichmann H.E.; Krawczak M.; Ivandic B.; Weichenhan D.; Gelbrich G.; El-Mokhtari N.E.; Schreiber S.; Felix S.B.; Hasenfuß G.; Pfeufer A.; Huebner N.; Kaeaeb S.; Arbustini E.; Rottbauer W.; Frey N.; Stoll M.; Katus H.A.
A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy
European Heart Journal 35 (16): 1069-1077 (2013-07-12)



Knueppel S.; Rohde K.; Meidtner K.; Drogan D.; Holzhuetter H.G.; Boeing H.; Fisher E.
Evaluation of 41 candidate gene variants for obesity in the EPIC-Potsdam cohort by multi-locus stepwise regression
PLoS ONE 8 (7): e68941 (2013-07-12)



Arndt A.K.; Schaefer S.; Drenckhahn J.D.; Sabeh M.K.; Plovie E.R.; Caliebe A.; Klopocki E.; Musso G.; Werdich A.A.; Kalwa H.; Heinig M.; Padera R.F.; Wassilew K.; Bluhm J.; Harnack C.; Martitz J.; Barton P.J.; Greutmann M.; Berger F.; Huebner N.; Siebert R.; Kramer H.H.; Cook S.A.; Macrae C.A.; Klaassen S.
Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy
American Journal of Human Genetics 93 (1): 67-77 (2013-07-11)



Freitag N.; Tirado-Gonzalez I.; Barrientos G.; Herse F.; Thijssen V.L.J.L.; Weedon-Fekjaer S.M.; Schulz H.; Wallukat G.; Klapp B.F.; Nevers T.; Sharma S.; Staff A.C.; Dechend R.; Blois S.M.
Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia
Proceedings of the National Academy of Sciences of the United States of America 110 (28): 11451-11456 (2013-07-09)



Ellinghaus D.; Baurecht H.; Esparza-Gordillo J.; Rodriguez E.; Matanovic A.; Marenholz I.; Huebner N.; Schaarschmidt H.; Novak N.; Michel S.; Maintz L.; Werfel T.; Meyer-Hoffert U.; Hotze M.; Prokisch H.; Heim K.; Herder C.; Hirota T.; Tamari M.; Kubo M.; Takahashi A.; Nakamura Y.; Tsoi L.C.; Stuart P.; Elder J.T.; Sun L.; Zuo X.; Yang S.; Zhang X.; Hoffmann P.; Noethen M.M.; Foelster-Holst R.; Winkelmann J.; Illig T.; Boehm B.O.; Duerr R.H.; Buening C.; Brandt S.; Glas J.; McAleer M.A.; Fahy C.M.; Kabesch M.; Brown S.; McLean W.H.I.; Irvine A.D.; Schreiber S.; Lee Y.A.; Franke A.; Weidinger S.
High-density genotyping study identifies four new susceptibility loci for atopic dermatitis
Nature Genetics 45 (7): 808-812 (2013-07)



Gandolgor T.A.; Ohara H.; Cui Z.H.; Hirashima T.; Ogawa T.; Saar K.; Huebner N.; Watanabe T.; Isomura M.; Nabika T.
Two genomic regions of chromosomes 1 and 18 explain most of the stroke susceptibility under salt loading in stroke-prone spontaneously hypertensive Rat/Izm
Hypertension 62 (1): 55-61 (2013-07)



Baud A.; Hermsen R.; Guryev V.; Stridh P.; Graham D.; McBride M.W.; Foroud T.; Calderari S.; Diez M.; Ockinger J.; Beyeen A.D.; Gillett A.; Abdelmagid N.; Guerreiro-Cacais A.O.; Jagodic M.; Tuncel J.; Norin U.; Beattie E.; Huynh N.; Miller W.H.; Koller D.L.; Alam I.; Falak S.; Osborne-Pellegrin M.; Martinez-Membrives E.; Canete T.; Blazquez G.; Vicens-Costa E.; Mont-Cardona C.; Diaz-Moran S.; Tobena A.; Hummel O.; Zelenika D.; Saar K.; Patone G.; Bauerfeind A.; Bihoreau M.T.; Heinig M.; Lee Y.A.; Rintisch C.; Schulz H.; Wheeler D.A.; Worley K.C.; Muzny D.M.; Gibbs R.A.; Lathrop M.; Lansu N.; Toonen P.; Ruzius F.P.; de Bruijn E.; Hauser H.; Adams D.J.; Keane T.; Atanur S.S.; Aitman T.J.; Flicek P.; Malinauskas T.; Jones E.Y.; Ekman D.; Lopez-Aumatell R.; Dominiczak A.F.; Johannesson M.; Holmdahl R.; Olsson T.; Gauguier D.; Hubner N.; Fernandez-Teruel A.; Cuppen E.; Mott R.; Flint J.
Combined sequence-based and genetic mapping analysis of complex traits in outbred rats
Nature Genetics 45 (7): 767-775 (2013-07)



Ma X.; Wehland M.; Schulz H.; Saar K.; Huebner N.; Infanger M.; Bauer J.; Grimm D.
Genomic approach to identify factors that drive the formation of three-dimensional structures by EA.hy926 endothelial cells
PLoS ONE 8 (5): e64402 (2013-05-10)



Gong M.; Simaite D.; Kuehnen P.; Heldmann M.; Spagnoli F.; Blankenstein O.; Huebner N.; Hussain K.; Raile K.
Two novel GATA6 mutations cause childhood-onset diabetes mellitus, pancreas malformation and congenital heart disease
Hormone Research in Paediatrics 79 (4): 250-256 (2013-05)



Knapp D.; Schulz H.; Rascon C.A.; Volkmer M.; Scholz J.; Nacu E.; Le M.; Novozhilov S.; Tazaki A.; Protze S.; Jacob T.; Hubner N.; Habermann B.; Tanaka E.M.
Comparative transcriptional profiling of the axolotl limb identifies a tripartite regeneration-specific gene program
PLoS ONE 8 (5): e61352 (2013-05-01)



Liska F.; Gosele C.; Popova E.; Chylikova B.; Krenova D.; Kren V.; Bader M.; Tres L.L.; Hubner N.; Kierszenbaum A.L.
Overexpression of full-length centrobin rescues limb malformation but not male fertility of the hypodactylous (hd) rats
PLoS ONE 8 (4): e60859 (2013-04-08)



Langley S.R.; Bottolo L.; Kunes J.; Zicha J.; Zidek V.; Hubner N.; Cook S.A.; Pravenec M.; Aitman T.J.; Petretto E.
Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans
Cardiovascular Research 97 (4): 653-665 (2013-03-15)



Suter B.; Fontaine J.F.; Yildirimman R.; Rasko T.; Schaefer M.H.; Rasche A.; Porras P.; Vazquez-Alvarez B.M.; Russ J.; Rau K.; Foulle R.; Zenkner M.; Saar K.; Herwig R.; Andrade-Navarro M.A.; Wanker E.E.
Development and application of a DNA microarray-based yeast two-hybrid system
Nucleic Acids Research 41 (3): 1496-507 (2013-02-01)



Wu Y.J.; Schulz H.; Lin C.C.; Saar K.; Patone G.; Fischer H.; Huebner N.; Heimrich B.; Schwemmle M.
Borna disease virus-induced neuronal degeneration dependent on host genetic background and prevented by soluble factors
Proceedings of the National Academy of Sciences of the United States of America 110 (5): 1899-1904 (2013-01-29)



Uhlenhaut N.H.; Barish G.D.; Yu R.T.; Downes M.; Karunasiri M.; Liddle C.; Schwalie P.; Huebner N.; Evans R.M.
Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes
Molecular Cell 49 (1): 158-171 (2013-01-10)



Chuykin I.; Schulz H.; Guan K.; Bader M.
Activation of the PTHRP/adenylate cyclase pathway promotes differentiation of rat XEN cells into parietal endoderm, whereas Wnt/beta-catenin signaling promotes differentiation into visceral endoderm
Journal of Cell Science 126 (Pt 1): 128-138 (2013-01-01)



Yang C.; Stingo F.C.; Ahn K.W.; Liu P.; Vannucci M.; Laud P.W.; Skelton M.; O’Connor P.; Kurth T.; Ryan R.P.; Moreno C.; Tsaih S.W.; Patone G.; Hummel O.; Jacob H.J.; Liang M.; Cowley A.W.
Increased proliferative cells in the medullary thick ascending limb of the loop of henle in the dahl salt-sensitive rat
Hypertension 61 (1): 208-215 (2013-01)



2012

Steffens M.; Leu C.; Ruppert A.K.; Zara F.; Striano P.; Robbiano A.; Capovilla G.; Tinuper P.; Gambardella A.; Bianchi A.; La Neve A.; Crichiutti G.; de Kovel C.G.F.; Kasteleijn-Nolst Trenite D.; de Haan G.J.; Lindhout D.; Gaus V.; Schmitz B.; Janz D.; Weber Y.G.; Becker F.; Lerche H.; Steinhoff B.J.; Kleefuss-Lie A.A.; Kunz W.S.; Surges R.; Elger C.E.; Muhle H.; von Spiczak S.; Ostertag P.; Helbig I.; Stephani U.; Moller R.S.; Hjalgrim H.; Dibbens L.M.; Bellows S.; Oliver K.; Mullen S.; Scheffer I.E.; Berkovic S.F.; Everett K.V.; Gardiner M.R.; Marini C.; Guerrini R.; Lehesjoki A.E.; Siren A.; Guipponi M.; Malafosse A.; Thomas P.; Nabbout R.; Baulac S.; Leguern E.; Guerrero R.; Serratosa J.M.; Reif P.S.; Rosenow F.; Mörzinger M.; Feucht M.; Zimprich F.; Kapser C.; Schankin C.J.; Suls A.; Smets K.; De Jonghe P.; Jordanova A.; Caglayan H.; Yapici Z.; Yalcin D.A.; Baykan B.; Bebek N.; Ozbek U.; Gieger C.; Wichmann H.E.; Balschun T.; Ellinghaus D.; Franke A.; Meesters C.; Becker T; Wienker T.F.; Hempelmann A.; Schulz H.; Rueschendorf F.; Leber M.; Pauck S.M.; Trucks H.; Toliat M.R.; Nuernberg P.; Avanzini G.; Koeleman B.P.; Sander T.
Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32
Human Molecular Genetics 21 (24): 5359-5372 (2012-12-15)



Grosse J.; Wehland M.; Pietsch J.; Schulz H.; Saar K.; Huebner N.; Eilles C.; Bauer J.; Abou-El-Ardat K.; Baatout S.; Ma X.; Infanger M.; Hemmersbach R.; Grimm D.
Gravity-sensitive signaling drives 3-dimensional formation of multicellular thyroid cancer spheroids
FASEB Journal 26 (12): 5124-5140 (2012-12)



Maass P.G.; Rump A.; Schulz H.; Stricker S.; Schulze L.; Platzer K.; Aydin A.; Tinschert S.; Goldring M.B.; Luft F.C.; Baehring S.
A misplaced lncRNA causes brachydactyly in humans
Journal of Clinical Investigation 122 (11): 3990-4002 (2012-11-01)



Schulte L.; Schulz A.; Unland J.; Schulz H.; Hubner N.; Schmidt-Ott K.M.; Kreutz R.
MWF rats with spontaneous albuminuria inherit a reduced efficiency of nephron induction during early nephrogenesis in comparison to SHRs
Journal of Hypertension 30 (10): 2031-2038 (2012-10)



Gaspar J.A.; Doss M.X.; Winkler J.; Wagh V.; Hescheler J.; Kolde R.; Vilo J.; Schulz H.; Sachinidis A.
Gene expression signatures defining fundamental biological processes in pluripotent, early, and late differentiated embryonic stem cells
Stem Cells and Development 21 (13): 2471-2484 (2012-09-01)



Klaus A.; Mueller M.; Schulz H.; Saga Y.; Martin J.F.; Birchmeier W.
Wnt/beta-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells
Proceedings of the National Academy of Sciences of the United States of America 109 (27): 10921-10926 (2012-07-03)



Preising M.N.; Hausotter-Will N.; Solbach M.C.; Friedburg C.; Rueschendorf F.; Lorenz B.
Mutations in RD3 are associated with an extremely rare and severe form of early onset retinal dystrophy
Investigative Ophthalmology & Visual Science 53 (7): 3463-3472 (2012-06-08)



Dizier M.H.; Margaritte-Jeannin P.; Madore A.M.; Esparza-Gordillo J.; Moffatt M.F.; Corda E.; Monier F.; Guilloud-Bataille M.; Franke A.; Weidinger S.; Annesi-Maesano I.; Just J.; Pin I.; Kauffmann F.; Cookson W.; Lee Y.A.; Laprise C.; Lathrop M.; Bouzigon E.; Demenais F.
The ANO3/MUC15 locus is associated with eczema in families ascertained through asthma
Journal of Allergy and Clinical Immunology 129 (6): 1547-1553 (2012-06)



Frenzel H.; Bohlender J.; Pinsker K.; Wohlleben B.; Tank J.; Lechner S.G.; Schiska D.; Jaijo T.; Rueschendorf F.; Saar K.; Jordan J.; Millan J.M.; Gross M.; Lewin G.R.
A genetic basis for mechanosensory traits in humans
PLoS Biology 10 (5): e1001318 (2012-05-01)



Guo W.; Schafer S.; Greaser M.L.; Radke M.H.; Liss M.; Govindarajan T.; Maatz H.; Schulz H.; Lincoln S.E.; Parrish A.M.; Dauksaite V.; Vakeel P.; Klaassen S.; Gerull B.; Thierfelder L.; Regitz-Zagrosek V.; Hacker T.A.; Saupe K.W.; Dec G.W.; Ellinor P.T.; MacRae C.A.; Spallek B.; Fischer R.; Perrot A.; Ozcelik C.; Saar K.; Hubner N.; Gotthardt M.
RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing
Nature Medicine 18 (5): 766-773 (2012-05)



Doss M.X.; Gaspar J.A.; Winkler J.; Hescheler J.; Schulz H.; Sachinidis A.
Specific gene signatures and pathways in mesodermal cells and their derivatives derived from embryonic stem cells
Stem Cell Reviews and Reports 8 (1): 43-54 (2012-03)



Caglayan S.; Bauerfeind A.; Schmidt V.; Carlo A.S.; Prabakaran T.; Huebner N.; Willnow T.E.
Identification of Alzheimer disease risk genotype that predicts efficiency of SORL1 expression in the brain
Archives of Neurology 69 (3): 373-379 (2012-03)



Chakraborty D.; Kappei D.; Theis M.; Nitzsche A.; Ding L.; Paszkowski-Rogacz M.; Surendranath V.; Berger N.; Schulz H.; Saar K.; Hubner N.; Buchholz F.
Combined RNAi and localization for functionally dissecting long noncoding RNAs
Nature Methods 9 (4): 360-362 (2012-02-12)



Baumann M.; Giunta C.; Krabichler B.; Rueschendorf F.; Zoppi N.; Colombi M.; Bittner R.E.; Quijano-Roy S.; Muntoni F.; Cirak S.; Schreiber G.; Zou Y.; Hu Y.; Romero N.B.; Carlier R.Y.; Amberger A.; Deutschmann A.; Straub V.; Rohrbach M.; Steinmann B.; Rostasy K.; Karall D.; Boennemann C.G.; Zschocke J.; Fauth C.
Mutations in FKBP14 cause a variant of Ehlers-Danlos syndrome with progressive kyphoscoliosis, myopathy, and hearing loss
American Journal of Human Genetics 90 (2): 201-216 (2012-02-10)



Leu C.; de Kovel C.G.F.; Zara F.; Striano P.; Pezzella M.; Robbiano A.; Bianchi A.; Bisulli F.; Coppola A.; Giallonardo A.T.; Beccaria F.; Trenite D.K.; Lindhout D.; Gaus V.; Schmitz B.; Janz D.; Weber Y.G.; Becker F.; Lerche H.; Kleefuss-Lie A.A.; Hallman K.; Kunz W.S.; Elger C.E.; Muhle H.; Stephani U.; Moller R.S.; Hjalgrim H.; Mullen S.; Scheffer I.E.; Berkovic S.F.; Everett K.V.; Gardiner M.R.; Marini C.; Guerrini R.; Lehesjoki A.E.; Siren A.; Nabbout R.; Baulac S.; Leguern E.; Serratosa J.M.; Rosenow F.; Feucht M.; Unterberger I.; Covanis A.; Suls A.; Weckhuysen S.; Kaneva R.; Caglayan H.; Turkdogan D.; Baykan B.; Bebek N.; Ozbek U.; Hempelmann A.; Schulz H.; Rueschendorf F.; Trucks H.; Nuernberg P.; Avanzini G.; Koeleman B.P.C.; Sander T.
Genome-wide linkage meta-analysis identifies susceptibility loci at 2q34 and 13q31.3 for genetic generalized epilepsies
Epilepsia 53 (2): 308-318 (2012-02)



Grosse J.; Wehland M.; Pietsch J.; Ma X.; Ulbrich C.; Schulz H.; Saar K.; Huebner N.; Hauslage J.; Hemmersbach R.; Braun M.; van Loon J.; Vagt N.; Infanger M.; Eilles C.; Egli M.; Richter P.; Baltz T.; Einspanier R.; Sharbati S.; Grimm D.
Short-term weightlessness produced by parabolic flight maneuvers altered gene expression patterns in human endothelial cells
FASEB Journal 26 (2): 639-655 (2012-02)



Jackson M.; Axton R.A.; Taylor A.H.; Wilson J.A.; Gordon-Keylock S.A.; Kokkaliaris K.; Brickman J.M.; Schulz H.; Hummel O.; Hubner N.; Forrester L.M.
HOXB4 can enhance the differentiation of embryonic stem cells by modulating the haematopoietic niche
Stem Cells 30 (2): 150-160 (2012-02)



Knuppel S.; Esparza-Gordillo J.; Marenholz I.; Holzhutter H.; Bauerfeind A.; Ruether A.; Weidinger S.; Lee Y.A.; Rohde K.
Multi-locus stepwise regression: a haplotype-based algorithm for finding genetic associations applied to atopic dermatitis
BMC Medical Genetics 13 (1): 8 (2012-01-27)



2011

Morrissey C.; Grieve I.C.; Heinig M.; Atanur S.; Petretto E.; Pravenec M.; Hubner N.; Aitman T.J.
Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat
Physiological Genomics 43 (21): 1207-1218 (2011-11-07)



Blaydon D.C.; Biancheri P.; Di W.L.; Plagnol V.; Cabral R.M.; Brooke M.A.; van Heel D.A.; Ruschendorf F.; Toynbee M.; Walne A.; O'Toole E.A.; Martin J.E.; Lindley K.; Vulliamy T.; Abrams D.J.; MacDonald T.T.; Harper J.I.; Kelsell D.P.
Inflammatory skin and bowel disease linked to ADAM17 deletion
New England Journal of Medicine 365 (16): 1502-1508 (2011-10-20)



McDermott-Roe C.; Ye J.; Ahmed R.; Sun X.M.; Serafin A.; Ware J.; Bottolo L.; Muckett P.; Canas X.; Zhang J.; Rowe G.C.; Buchan R.; Lu H.; Braithwaite A.; Mancini M.; Hauton D.; Marti R.; Garcia-Arumi E.; Hubner N.; Jacob H.; Serikawa T.; Zidek V.; Papousek F.; Kolar F.; Cardona M.; Ruiz-Meana M.; Garcia-Dorado D.; Comella J.X.; Felkin L.E.; Barton P.J.; Arany Z.; Pravenec M.; Petretto E.; Sanchis D.; Cook S.A.
Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function
Nature 478 (7367): 114-118 (2011-10-06)



Ulbrich C.; Pietsch J.; Grosse J.; Wehland M.; Schulz H.; Saar K.; Huebner N.; Hauslage J.; Hemmersbach R.; Braun M.; van Loon J.; Vagt N.; Egli M.; Richter P.; Einspanier R.; Sharbati S.; Baltz T.; Infanger M.; Ma X.; Grimm D.
Differential gene regulation under altered gravity conditions in follicular thyroid cancer cells: relationship between the extracellular matrix and the cytoskeleton
Cellular Physiology and Biochemistry 28 (2): 185-198 (2011-08-16)



Marenholz I.; Rivera V.A.; Esparza-Gordillo J.; Bauerfeind A.; Lee-Kirsch M.A.; Ciechanowicz A.; Kurek M.; Piskackova T.; Macek M.; Lee Y.A.
Association screening in the epidermal differentiation complex (EDC) identifies an SPRR3 repeat number variant as a risk factor for eczema
Journal of Investigative Dermatology 131 (8): 1644-1649 (2011-08)



Stodola T.J.; de Resende M.M.; Sarkis A.B.; Didier D.N.; Jacob H.J.; Huebner N.; Hummel O.; Saar K.; Moreno C.; Greene A.S.
Characterization of the genomic structure and function of regions influencing renin and angiogenesis in the SS rat
Physiological Genomics 43 (13): 808-817 (2011-07-14)



Wenzel K.; Rajakumar A.; Haase H.; Geusens N.; Hubner N.; Schulz H.; Brewer J.; Roberts L.; Hubel C.A.; Herse F.; Hering L.; Qadri F.; Lindschau C.; Wallukat G.; Pijnenborg R.; Heidecke H.; Riemekasten G.; Luft F.C.; Muller D.N.; Lamarca B.; Dechend R.
Angiotensin II type 1 receptor antibodies and increased angiotensin II sensitivity in pregnant rats
Hypertension 58 (1): 77-84 (2011-07)



Marenholz I.; Bauerfeind A.; Esparza-Gordillo J.; Kerscher T.; Granell R.; Nickel R.; Lau S.; Henderson J.; Lee Y.A.
The eczema risk variant on chromosome 11q13 (rs7927894) in the population-based ALSPAC cohort: a novel susceptibility factor for asthma and hay fever
Human Molecular Genetics 20 (12): 2443-2449 (2011-06-15)



Nitzsche A.; Paszkowski-Rogacz M.; Matarese F.; Janssen-Megens E.M.; Hubner N.C.; Schulz H.; de Vries I.; Ding L.; Huebner N.; Mann M.; Stunnenberg H.G.; Buchholz F.
RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity
PLoS ONE 6 (5): e19470 (2011-05-12)



Charles R.L.; Burgoyne J.R.; Mayr M.; Weldon S.M.; Hubner N.; Dong H.; Morisseau C.; Hammock B.D.; Landar A.L.; Eaton P.
Redox regulation of soluble epoxide hydrolase by 15-deoxy-{delta}-prostaglandin J2 controls coronary hypoxic vasodilation
Circulation Research 108 (3): 324-334 (2011-02-04)



2010

Yagil Y.; Hessner M.J.; Schulz H.; Gosele C.; Lebdev L.; Barkalifa R.; Sapojnikov M.; Huebner N.; Yagil C.
Geno-transcriptomic dissection of proteinuria in the uninephrectomized rat uncovers a molecular complexity with sexual dimorphism
Physiological Genomics 42A (4): 301-316 (2010-11-29)



Toka O.; Maass P.G.; Aydin A.; Toka H.; Huebner N.; Rueschendorf F.; Gong M.; Luft F.C.; Baehring S.
Childhood hypertension in autosomal-dominant hypertension with brachydactyly
Hypertension 56 (5): 988-994 (2010-11)



Heinig M.; Petretto E.; Wallace C.; Bottolo L.; Rotival M.; Lu H.; Li Y.; Sarwar R.; Langley S.R.; Bauerfeind A.; Hummel O.; Lee Y.A.; Paskas S.; Rintisch C.; Saar K.; Cooper J.; Buchan R.; Gray E.E.; Cyster J.G.; Braund P.; Gracey J.; Krishnan U.; Moore J.S.; Nelson C.P.; Pollard H.; Attwood T.; Crisp-Hihn A.; Foad N.; Jolley J.; Lloyd-Jones H.; Muir D.; Murray E.; O'Leary K.; Rankin A.; Sambrook J.; Godfroy T.; Brocheton J.; Proust C.; Schmitz G.; Heimerl S.; Lugauer I.; Belz S.; Gulde S.; Linsel-Nitschke P.; Sager H.; Schroeder L.; Lundmark P.; Syvannen A.C.; Neudert J.; Scholz M.; Deloukas P.; Gray E.; Gwilliams R.; Niblett D.; Erdmann J.; Hengstenberg C.; Maouche S.; Ouwehand W.H.; Rice C.M.; Samani N.J.; Schunkert H.; Goodall A.H.; Schulz H.; Roider H.G.; Vingron M.; Blankenberg S.; Muenzel T.; Zeller T.; Szymczak S.; Ziegler A.; Tiret L.; Smyth D.J.; Pravenec M.; Aitman T.J.; Cambien F.; Clayton D.; Todd J.A.; Huebner N.; Cook S.A.
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk
Nature 467 (7314): 460-464 (2010-09-23)



Christ A.; Terryn S.; Schmidt V.; Christensen E.I.; Huska M.R.; Andrade-Navarro M.A.; Huebner N.; Devuyst O.; Hammes A.; Willnow T.E.
The soluble intracellular domain of megalin does not affect renal proximal tubular function in vivo
Kidney International 78 (5): 473-477 (2010-09)



Reutter H.; Rueschendorf F.; Mattheisen M.; Draaken M.; Bartels E.; Huebner N.; Hoffmann P.; Payabvash S.; Saar K.; Noethen M.M.; Kajbafzadeh A.M.; Ludwig M.
Evidence for linkage of the bladder exstrophy-epispadias complex on chromosome 4q31.21-22 and 19q13.31-41 from a consanguineous iranian family
Birth Defects Research. Part A, Clinical and Molecular Teratology 88 (9): 757-761 (2010-09)



Reese J.; Kraschewski A.; Anghelescu I.; Winterer G.; Schmidt L.G.; Gallinat J.; Rueschendorf F.; Rommelspacher H.; Wernicke C.
Haplotypes of dopamine and serotonin transporter genes are associated with antisocial personality disorder in alcoholics
Psychiatric Genetics 20 (4): 140-152 (2010-08)



Gong M.; Rueschendorf F.; Marx P.; Schulz H.; Kraft H.G.; Huebner N.; Koennecke H.C.
Clinical and genetic features in a family with CADASIL and high lipoprotein (a) values
Journal of Neurology 257 (8): 1240-1245 (2010-08)



Popovic M.; Paskas S.; Zivkovic M.; Burysek L.; Laumonnier Y.
Human cytomegalovirus increases HUVEC sensitivity to thrombin and modulates expression of thrombin receptors
Journal of Thrombosis and Thrombolysis 30 (2): 164-171 (2010-08)



Jirout M.L.; Friese R.S.; Mahapatra N.R.; Mahata M.; Taupenot L.; Mahata S.K.; Kren V.; Zidek V.; Fischer J.; Maatz H.; Ziegler M.G.; Pravenec M.; Huebner N.; Aitman T.J.; Schork N.J.; O'Connor D.T.
Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat
Human Molecular Genetics 19 (13): 2567-2580 (2010-07-01)



Atanur S.S.; Birol I.; Guryev V.; Hirst M.; Hummel O.; Morrissey C.; Behmoaras J.; Fernandez-Suarez X.M.; Johnson M.D.; McLaren W.M.; Patone G.; Petretto E.; Plessy C.; Rockland K.S.; Rockland C.; Saar K.; Zhao Y.; Carninci P.; Flicek P.; Kurtz T.; Cuppen E.; Pravenec M.; Huebner N.; Jones S.J.; Birney E.; Aitman T.J.
The genome sequence of the spontaneously hypertensive rat: analysis and functional significance
Genome Research 20 (6): 791-803 (2010-06)



Zeller T.; Wild P.; Szymczak S.; Rotival M.; Schillert A.; Castagne R.; Maouche S.; Germain M.; Lackner K.; Rossmann H.; Eleftheriadis M.; Sinning C.R.; Schnabel R.B.; Lubos E.; Mennerich D.; Rust W.; Perret C.; Proust C.; Nicaud V.; Loscalzo J.; Huebner N.; Tregouet D.; Muenzel T.; Ziegler A.; Tiret L.; Blankenberg S.; Cambien F.
Genetics and beyond - the transcriptome of human monocytes and disease susceptibility
PLoS ONE 5 (5): e10693 (2010-05-18)



de Kovel C.G.; Pinto D.; Tauer U.; Lorenz S.; Muhle H.; Leu C.; Neubauer B.A.; Hempelmann A.; Callenbach P.M.; Scheffer I.E.; Berkovic S.F.; Rudolf G.; Striano P.; Siren A.; Baykan B.; Sander T.; Lindhout D.; Kasteleijn-Nolst Trenite D.G.; Stephani U.; Koeleman B.P.
Whole-genome linkage scan for epilepsy-related photosensitivity: a mega-analysis
Epilepsy Research 89 (2-3): 286-294 (2010-05)



Petretto E.; Bottolo L.; Langley S.R.; Heinig M.; McDermott-Roe C.; Sarwar R.; Pravenec M.; Huebner N.; Aitman T.J.; Cook S.A.; Richardson S.
New insights into the genetic control of gene expression using a Bayesian multi-tissue approach
PLoS Computational Biology 6 (4): e1000737 (2010-04-08)



Manke T.; Heinig M.; Vingron M.
Quantifying the effect of sequence variation on regulatory interactions
Human Mutation 31 (4): 477-483 (2010-04)



Doss M.X.; Wagh V.; Schulz H.; Kull M.; Kolde R.; Pfannkuche K.; Nolden T.; Himmelbauer H.; Vilo J.; Hescheler J.; Sachinidis A.
Global transcriptomic analysis of murine embryonic stem cell-derived brachyury+ (T) cells
Genes to Cells 15 (3): 209-228 (2010-03)



Wenzel K.; Wallukat G.; Qadri F.; Huebner N.; Schulz H.; Hummel O.; Herse F.; Heuser A.; Fischer R.; Heidecke H.; Luft F.C.; Mueller D.N.; Dietz R.; Dechend R.
alpha(1A)-adrenergic receptor-directed autoimmunity induces left ventricular damage and diastolic dysfunction in rats
PLoS ONE 5 (2): e9409 (2010-02-24)



Joutel A.; Monet-Lepretre M.; Gosele C.; Baron-Menguy C.; Hammes A.; Schmidt S.; Lemaire-Carrette B.; Domenga V.; Schedl A.; Lacombe P.; Huebner N.
Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease
Journal of Clinical Investigation 120 (2): 433-445 (2010-02-01)



Ratelade J.; Arrondel C.; Hamard G.; Garbay S.; Harvey S.; Biebuyck N.; Schulz H.; Hastie N.; Pontoglio M.; Gubler M.C.; Antignac C.; Heidet L.
A murine model of Denys-Drash syndrome reveals novel transcriptional targets of WT1 in podocytes
Human Molecular Genetics 19 (1): 1-15 (2010-01-01)



Stellzig-Eisenhauer A.; Decker E.; Meyer-Marcotty P.; Rau C.; Fiebig B.S.; Kress W.; Saar K.; Rueschendorf F.; Huebner N.; Grimm T.; Witt E.; Weber B.H.
Die primaere Durchbruchsstoerung (PFE) - klinische und molekulargenetische Analyse [Primary failure of eruption (PFE) - clinical and molecular genetics analysis]
Journal of Orofacial Orthopedics 71 (1): 6-16 (2010-01)



Liska F.; Snajdr P.; Stricker S.; Goesele C.; Krenova D.; Mundlos S.; Huebner N.
Impairment of sox9 expression in limb buds of rats homozygous for hypodactyly mutation
Folia Biologica Prague 56 (2): 58-65 (2010)



Rolletschek A.; Schroeder I.S.; Schulz H.; Hummel O.; Huebner N.; Wobus A.M.
Characterization of mouse embryonic stem cell differentiation into the pancreatic lineage in vitro by transcriptional profiling, quantitative RT-PCR and immunocytochemistry
International Journal of Developmental Biology 54 (1): 41-54 (2010)



Wang Y.; Liska F.; Gosele C.; Sedova L.; Kren V.; Krenova D.; Ivics Z.; Huebner N.; Izsvak Z.
A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains
Genome Research 20 (1): 19-27 (2010-01)



2009

Fisher E.; Stefan N.; Saar K.; Drogan D.; Schulze M.B.; Fritsche A.; Joost H.G.; Haering H.U.; Huebner N.; Boeing H.; Weikert C.
Association of AHSG gene polymorphisms with fetuin-A plasma levels and cardiovascular diseases in the EPIC-Potsdam study
Circulation Cardiovascular Genetics 2 (6): 607-613 (2009-12)



Liska F.; Goesele C.; Rivkin E.; Tres L.; Cardoso M.C.; Domaing P.; Krejci E.; Snajdr P.; Lee-Kirsch M.A.; de Rooij D.G.; Kren V.; Krenova D.; Kierszenbaum A.L.; Huebner N.
Rat hd mutation reveals an essential role of centrobin in spermatid head shaping and assembly of the head-tail coupling apparatus
Biology of Reproduction 81 (6): 1196-1205 (2009-12)



Mariappan D.; Niemann R.; Gajewski M.; Winkler J.; Chen S.; Choorapoikayil S.; Bitzer M.; Schulz H.; Hescheler J.; Sachinidis A.
Somitovasculin, a novel endothelial-specific transcript involved in the vasculature development
Arteriosclerosis Thrombosis and Vascular Biology 29 (11): 1823-1829 (2009-11)



Tabakoff B.; Saba L.; Printz M.; Flodman P.; Hodgkinson C.; Goldman D.; Koob G.; Richardson H.N.; Kechris K.; Bell R.L.; Huebner N.; Heinig M.; Pravenec M.; Mangion J.; Legault L.; Dongier M.; Conigrave K.M.; Whitfield J.B.; Saunders J.; Grant B.; Hoffman P.L.
Genetical genomic determinants of alcohol consumption in rats and humans
BMC Biology 7 (1): 70 (2009-10-27)



Buschmann E.E.; Utz W.; Pagonas N.; Schulz-Menger J.; Busjahn A.; Monti J.; Maerz W.; Le Noble F.; Thierfelder L.; Dietz R.; Klauss V.; Gross M.; Buschmann I.R.
Improvement of fractional flow reserve and collateral flow by treatment with external counterpulsation (Art.Net.-2 Trial)
European Journal of Clinical Investigation 39 (10): 866-875 (2009-10)



Schulz H.; Kolde R.; Adler P.; Aksoy I.; Anastassiadis K.; Bader M.; Billon N.; Boeuf H.; Bourillot P.Y.; Buchholz F.; Dani C.; Doss M.X.; Forrester L.; Gitton M.; Henrique D.; Hescheler J.; Himmelbauer H.; Huebner N.; Karantzali E.; Kretsovali A.; Lubitz S.; Pradier L.; Rai M.; Reimand J.; Rolletschek A.; Sachinidis A.; Savatier P.; Stewart F.; Storm M.P.; Trouillas M.; Vilo J.; Welham M.J.; Winkler J.; Wobus A.M.; Hatzopoulos A.K.
The FunGenES database: a genomics resource for mouse embryonic stem cell differentiation
PLoS ONE 4 (9): e6804 (2009-09-03)



Kleefuss-Lie A.; Friedl W.; Cichon S.; Haug K.; Warnstedt M.; Alekov A.; Sander T.; Ramirez A.; Poser B.; Maljevic S.; Hebeisen S.; Kubisch C.; Rebstock J.; Horvath S.; Hallmann K.; Dullinger J.S.; Rau B.; Haverkamp F.; Beyenburg S.; Schulz H.; Janz D.; Giese B.; Muller-Newen G.; Propping P.; Elger C.E.; Fahlke C.; Lerche H.
CLCN2 variants in idiopathic generalized epilepsy
Nature Genetics 41 (9): 954-955 (2009-09)



Zitnik S.E.; Rueschendorf F.; Mueller S.; Sengler C.; Lee Y.A.; Griffioen R.W.; Meglio P.; Wahn U.; Witt H.; Nickel R.
IL13 variants are associated with total serum IgE and early sensitization to food allergens in children with atopic dermatitis
Pediatric Allergy and Immunology 20 (6): 551-555 (2009-09)



Mollet G.; Ratelade J.; Boyer O.; Muda A.O.; Morisset L.; Lavin T.A.; Kitzis D.; Dallman M.J.; Bugeon L.; Huebner N.; Gubler M.C.; Antignac C.; Esquive E.L.
Podocin inactivation in mature kidneys causes focal segmental glomerulosclerosis and nephrotic syndrome
Journal of the American Society of Nephrology 20 (10): 2181-2189 (2009-08-27)



Bourillot P.Y.; Aksoy I.; Schreiber V.; Wianny F.; Schulz H.; Hummel O.; Huebner N.; Savatier P.
Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog
Stem Cells 27 (8): 1760-1771 (2009-08)



Abranches E.; Silva M.; Pradier L.; Schulz H.; Hummel O.; Henrique D.; Bekman E.
Neural differentiation of embryonic stem cells in vitro: A road map to neurogenesis in the embryo
PLoS ONE 4 (7): e6286 (2009-07-21)



Vogel H.; Nestler M.; Rueschendorf F.; Block M.D.; Tischer S.; Kluge R.; Schurmann A.; Joost H.G.; Scherneck S.
Characterization of Nob3, a major quantitative trait locus for obesity and hyperglycemia on mouse chromosome 1
Physiological Genomics 38 (2): 226-232 (2009-07-09)



Neuhaus A.H.; Opgen-Rhein C.; Urbanek C.; Hahn E.; Ta T.M.; Seidelsohn M.; Strathmann S.; Kley F.; Wieseke N.; Sander T.; Dettling M.
COMT Val 158 Met polymorphism is associated with cognitive flexibility in a signal discrimination task in schizophrenia
Pharmacopsychiatry 42 (4): 141-144 (2009-07)



Henneke M.; Diekmann S.; Ohlenbusch A.; Kaiser J.; Engelbrecht V.; Kohlschuetter A.; Kraetzner R.; Madruga-Garrido M.; Mayer M.; Opitz L.; Rodriguez D.; Rueschendorf F.; Schumacher J.; Thiele H.; Thoms S.; Steinfeld R.; Nuernberg P.; Gaertner J.
RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection
Nature Genetics 41 (7): 773-775 (2009-07)



Ding L.; Paszkowski-Rogacz M.; Nitzsche A.; Slabicki M.M.; Heninger A.K.; Vries I.D.; Kittler R.; Junqueira M.; Shevchenko A.; Schulz H.; Huebner N.; Doss M.X.; Sachinidis A.; Hescheler J.; Iacone R.; Anastassiadis K.; Stewart A.F.; Pisabarro M.T.; Caldarelli A.; Poser I.; Theis M.; Buchholz F.
A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity
Cell Stem Cell 4 (5): 403-415 (2009-05-08)



Beier K.C.; Humberdros S.; Witt H.; Illi S.; Rueschendorf F.; Nickel R.; Lee Y.A.; Lau S.; Wahn U.; Hamelmann E.
ICOS-gene variants are not associated with atopic disease susceptibility in European children
Pediatric Allergy and Immunology 20 (3): 242-245 (2009-05)



Huck K.; Feyen O.; Niehues T.; Rueschendorf F.; Huebner N.; Laws H.J.; Telieps T.; Knapp S.; Wacker H.H.; Meindl A.; Jumaa H.; Borkhardt A.
Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation
Journal of Clinical Investigation 119 (5): 1350-1358 (2009-05)



Hoffmann K.; Planitz C.; Rueschendorf F.; Mueller-Myhsok B.; Stassen H.H.; Lucke B.; Mattheisen M.; Stumvoll M.; Bochmann R.; Zschornack M.; Wienker T.F.; Nuernberg P.; Reis A.; Luft F.C.; Lindner T.H.
A novel locus for arterial hypertension on chromosome 1p36 maps to a metabolic syndrome trait cluster in the Sorbs, a Slavic population isolate in Germany*
Journal of Hypertension 27 (5): 983-990 (2009-05)



Lebrun A.H.; Storch S.; Rueschendorf F.; Schmiedt M.L.; Kyttaelae A.; Mole S.E.; Kitzmueller C.; Saar K.; Mewasingh L.D.; Boda V.; Kohlschuetter A.; Ullrich K.; Braulke T.; Schulz A.
Retention of lysosomal protein CLN5 in the endoplasmic reticulum causes neuronal ceroid lipofuscinosis in Asian Sibship
Human Mutation 30 (5): E651-E661 (2009-05)



Esparza-Gordillo J.; Weidinger S.; Foelster-Holst R.; Bauerfeind A.; Rueschendorf F.; Patone G.; Rohde K.; Marenholz I.; Schulz F.; Kerscher T.; Huebner N.; Wahn U.; Schreiber S.; Franke A.; Vogler R.; Heath S.; Baurecht H.; Novak N.; Rodriguez E.; Illig T.; Lee-Kirsch M.A.; Ciechanowicz A.; Kurek M.; Piskackova T.; Macek M.; Lee Y.A.; Ruether A.
A common variant on chromosome 11q13 is associated with atopic dermatitis
Nature Genetics 41 (5): 596-601 (2009-05)



Storm M.P.; Kumpfmueller B.; Thompson B.; Kolde R.; Vilo J.; Hummel O.; Schulz H.; Welham M.J.
Characterization of the phosphoinositide 3-kinase-dependent transcriptome in murine embryonic stem cells: identification of novel regulators of pluripotency
Stem Cells 27 (4): 764-775 (2009-04)



Marenholz I.; Kerscher T.; Bauerfeind A.; Esparza-Gordillo J.; Nickel R.; Keil T.; Lau S.; Rohde K.; Wahn U.; Lee Y.A.
An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma
Journal of Allergy and Clinical Immunology 123 (4): 911-916 (2009-04)



Heinz-Erian P.; Mueller T.; Krabichler B.; Schranz M.; Becker C.; Rueschendorf F.; Nuernberg P.; Rossier B.; Vujic M.; Booth I.W.; Holmberg C.; Wijmenga C.; Grigelioniene G.; Kneepkens C.M.; Rosipal S.; Mistrik M.; Kappler M.; Michaud L.; Doczy L.C.; Siu V.M.; Krantz M.; Zoller H.; Utermann G.; Janecke A.R.
Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea
American Journal of Human Genetics 84 (2): 188-196 (2009-02-13)



Trouillas M.; Saucourt C.; Guillotin B.; Gauthereau X.; Ding L.; Buchholz F.; Doss M.X.; Sachinidis A.; Hescheler J.; Hummel O.; Huebner N.; Kolde R.; Vilo J.; Schultz H.; Boeuf H.
Three LIF-dependent signatures and gene clusters with atypical expression profiles, identified by transcriptome studies in mouse ES cells and early derivatives
BMC Genomics 10 (1): 73 (2009-02-09)



Helbig I.; Mefford H.C.; Sharp A.J.; Guipponi M.; Fichera M.; Franke A.; Muhle H.; de Kovel C.; Baker C.; von Spiczak S.; Kron K.L.; Steinich I.; Kleefuss-Lie A.A.; Leu C.; Gaus V.; Schmitz B.; Klein K.M.; Reif P.S.; Rosenow F.; Weber Y.; Lerche H.; Zimprich F.; Urak L.; Fuchs K.; Feucht M.; Genton P.; Thomas P.; Visscher F.; de Haan G.J.; Moller R.S.; Hjalgrim H.; Luciano D.; Wittig M.; Nothnagel M.; Elger C.E.; Nuernberg P.; Romano C.; Malafosse A.; Koeleman B.P.C.; Lindhout D.; Stephani U.; Schreiber S.; Eichler E.E.; Sander T.
15q13.3 microdeletions increase risk of idiopathic generalized epilepsy
Nature Genetics 41 (2): 160-162 (2009-02)



Ludwig M.; Rueschendorf F.; Saar K.; Huebner N.; Siekmann L.; Boyadjiev S.A.; Reutter H.
Genome-wide linkage scan for bladder exstrophy-epispadias complex
Birth Defects Research A 85 (2): 174-8 (2009-02)



Mariappan D.; Winkler J.; Chen S.; Schulz H.; Hescheler J.; Sachinidis A.
Transcriptional profiling of CD31(+) cells isolated from murine embryonic stem cells
Genes to Cells 14 (2): 243-260 (2009-02)



Potta S.P.; Liang H.; Pfannkuche K.; Winkler J.; Chen S.; Doss M.X.; Obernier K.; Kamisetti N.; Schulz H.; Huebner N.; Hescheler J.; Sachinidis A.
Functional characterization and transcriptome analysis of embryonic stem cell-derived contractile smooth muscle cells
Hypertension 53 (2): 196-204 (2009-02)



Lang U.E.; Hellweg R.; Sander T.; Gallinat J.
The Met allele of the BDNF Val66Met polymorphism is associated with increased BDNF serum concentrations
Molecular Psychiatry 14 (2): 120-122 (2009-02)



Hildebrandt F.; Heeringa S.F.; Rueschendorf F.; Attanasio M.; Nuernberg G.; Becker C.; Seelow D.; Huebner N.; Chernin G.; Vlangos C.N.; Zhou W.; O'Toole J.F.; Hoskins B.E.; Wolf M.T.; Hinkes B.G.; Chaib H.; Ashraf S.; Allen S.J.; Vega-Warner V.; Wise E.; Harville H.M.; Lyons R.H.; Washburn J.; Macdonald J.; Nuernberg P.; Otto E.A.
A systematic approach to mapping recessive disease genes in individuals from outbred populations
PLoS Genetics 5 (1): e1000353 (2009-01-23)



Popovic M.; Paskas S.; Zivkovic M.; Duric-Delic T.; Stankovic A.; Burysek L.
In HCMV-exposed HUVEC, P52/RelB regulatory factors mediate activation of the human PAR1 gene promoter
Archives of Biological Sciences 61 (4): 613-618 (2009)



2008

Grieve I.C.; Dickens N.J.; Pravenec M.; Kren V.; Huebner N.; Cook S.A.; Aitman T.J.; Petretto E.; Mangion J.
Genome-wide co-expression analysis in multiple tissues
PLoS ONE 3 (12): e4033 (2008-12-29)



Decker E.; Stellzig-Eisenhauer A.; Fiebig B.S.; Rau C.; Kress W.; Saar K.; Rueschendorf F.; Huebner N.; Grimm T.; Weber B.H.
PTHR1 loss-of-function mutations in familial, nonsyndromic primary failure of tooth eruption
American Journal of Human Genetics 83 (6): 781-786 (2008-12-12)



Wenzel K.; Haase H.; Wallukat G.; Derer W.; Bartel S.; Homuth V.; Herse F.; Huebner N.; Schulz H.; Janczikowski M.; Lindschau C.; Schroeder C.; Verlohren S.; Morano I.; Mueller D.N.; Luft F.C.; Dietz R.; Dechend R.; Karczewski P.
Potential relevance of alpha(1)-adrenergic receptor autoantibodies in refractory hypertension
PLoS ONE 3 (11): e3742 (2008-11-17)



Opgen-Rhein C.; Neuhaus A.H.; Urbanek C.; Hahn E.; Sander T.; Dettling M.
Executive attention in schizophrenic males and the impact of COMT Val108/158Met genotype on performance on the Attention Network Test
Schizophrenia Bulletin 34 (6): 1231-1239 (2008-11)



Gotthardt D.; Runz H.; Keitel V.; Fischer C.; Flechtenmacher C.; Wirtenberger M.; Weiss K.H.; Imparato S.; Braun A.; Hemminki K.; Stremmel W.; Rueschendorf F.; Stiehl A.; Kubitz R.; Burwinkel B.; Schirmacher P.; Knisely A.S.; Zschocke J.; Sauer P.
A mutation in the canalicular phospholipid transporter gene, ABCB4, is associated with cholestasis, ductopenia, and cirrhosis in adults
Hepatology 48 (4): 1157-1166 (2008-10)



Schmack K.; Schlagenhauf F.; Sterzer P.; Wrase J.; Beck A.; Dembler T.; Kalus P.; Puls I.; Sander T.; Heinz A.; Gallinat J.
Catechol-O-methyltransferase val158met genotype influences neural processing of reward anticipation
NeuroImage 42 (4): 1053-8119 (2008-10-01)



Pravenec M.; Churchill P.C.; Churchill M.C.; Viklicky O.; Kazdova L.; Aitman T.J.; Petretto E.; Huebner N.; Wallace C.A.; Zimdahl H.; Zidek V.; Landa V.; Dunbar J.; Bidani A.; Griffin K.; Qi N.; Maxova M.; Kren V.; Mlejnek P.; Wang J.; Kurtz T.W.
Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension
Nature Genetics 40 (8): 952-954 (2008-08)



Ratelade J.; Lavin T.A.; Muda A.O.; Morisset L.; Mollet G.; Boyer O.; Chen D.S.; Henger A.; Kretzler M.; Huebner N.; Thery C.; Gubler M.C.; Montagutelli X.; Antignac C.; Esquivel E.L.
Maternal environment interacts with modifier genes to influence progression of nephrotic syndrome
Journal of the American Society of Nephrology 19 (8): 1491-1499 (2008-08)



Kota L.T.; Schulz H.; Falak S.; Huebner N.; Osborne-Pellegrin M.
Localization of genetic loci controlling hydronephrosis in the Brown Norway rat and its association with hematuria
Physiological Genomics 34 (2): 215-224 (2008-07-15)



Ackermann G.E.; Domenighetti A.A.; Deten A.; Bonath I.; Marenholz I.; Pedrazzini T.; Erne P.; Heizmann C.W.
S100A1 deficiency results in prolonged ventricular repolarization in response to sympathetic activation
General Physiology and Biophysics 27 (2): 127-142 (2008-06)



Nagel I.E.; Chicherio C.; Li S.C.; von Oertzen T.; Sander T.; Villringer A.; Heekeren H.R.; Baeckman L.; Lindenberger U.
Human aging magnifies genetic effects on executive functioning and working memory
Frontiers in Human Neuroscience 2: 1 (2008-05-03)



Monti J.; Fischer J.; Paskas S.; Heinig M.; Schulz H.; Goesele C.; Heuser A.; Fischer R.; Schmidt C.; Schirdewan A.; Gross V.; Hummel O.; Maatz H.; Patone G.; Saar K.; Vingron M.; Weldon S.M.; Lindpaintner K.; Hammock B.D.; Rohde K.; Dietz R.; Cook S.A.; Schunck W.H.; Luft F.C.; Huebner N.
Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease
Nature Genetics 40 (5): 529-537 (2008-05)



Saar K.; Beck A.; Bihoreau M.T.; Birney E.; Brocklebank D.; Chen Y.; Cuppen E.; Demonchy S.; Dopazo J.; Flicek P.; Foglio M.; Fujiyama A.; Gut I.G.; Gauguier D.; Guigo R.; Guryev V.; Heinig M.; Hummel O.; Jahn N.; Klages S.; Kren V.; Kube M.; Kuhl H.; Kuramoto T.; Kuroki Y.; Lechner D.; Lee Y.A.; Lopez-Bigas N.; Lathrop G.M.; Mashimo T.; Medina I.; Mott R.; Patone G.; Perrier-Cornet J.A.; Platzer M.; Pravenec M.; Reinhardt R.; Sakaki Y.; Schilhabel M.; Schulz H.; Serikawa T.; Shikhagaie M.; Tatsumoto S.; Taudien S.; Toyoda A.; Voigt B.; Zelenika D.; Zimdahl H.; Huebner N.
SNP and haplotype mapping for genetic analysis in the rat
Nature Genetics 40 (5): 560-566 (2008-05)



Aitman T.J.; Critser J.K.; Cuppen E.; Dominiczak A.; Fernandez-Suarez X.M.; Flint J.; Gauguier D.; Geurts A.M.; Gould M.; Harris P.C.; Holmdahl R.; Huebner N.; Izsvak Z.; Jacob H.J.; Kuramoto T.; Kwitek A.E.; Marrone A.; Mashimo T.; Moreno C.; Mullins J.; Mullins L.; Olsson T.; Pravenec M.; Riley L.; Saar K.; Serikawa T.; Shull J.D.; Szpirer C.; Twigger S.N.; Voigt B.; Worley K.C.
Progress and prospects in rat genetics: a community view
Nature Genetics 40 (5): 516-22 (2008-05)



Petretto E.; Sarwar R.; Grieve I.; Lu H.; Kumaran M.K.; Muckett P.J.; Mangion J.; Schroen B.; Benson M.; Punjabi P.P.; Prasad S.K.; Pennell D.J.; Kiesewetter C.; Tasheva E.S.; Corpuz L.M.; Webb M.D.; Conrad G.W.; Kurtz T.W.; Kren V.; Fischer J.; Huebner N.; Pinto Y.M.; Pravenec M.; Aitman T.J.; Cook S.A.
Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass
Nature Genetics 40 (5): 546-552 (2008-05)



Guryev V.; Saar K.; Adamovic T.; Verheul M.; van Heesch S.A.; Cook S.; Pravenec M.; Aitman T.; Jacob H.; Shull J.D.; Huebner N.; Cuppen E.
Distribution and functional impact of DNA copy number variation in the rat
Nature Genetics 40 (5): 538-545 (2008-05)



Gilibert S.; Kwitek A.E.; Huebner N.; Tschannen M.; Jacob H.J.; Sassard J.; Bataillard A.P.
The effects of chromosome 17 on features of the metabolic syndrome in the Lyon Hypertensive (LH) rat
Physiological Genomics 33 (2): 212-217 (2008-04-22)



Karantzali E.; Schulz H.; Hummel O.; Huebner N.; Hatzopoulos A.; Kretsovali A.
Histone deacetylase inhibition accelerates the early events of stem cell differentiation: transcriptomic and epigenetic analysis
Genome Biology 9 (4): R65 (2008-04-04)



Puk O.; Loester J.; Dalke C.; Soewarto D.; Fuchs H.; Budde B.; Nuernberg P.; Wolf E.; de Angelis M.H.; Graw J.
Mutation in a novel connexin-like gene (Gjf1) in the mouse affects early lens development and causes a variable small-eye phenotype
Investigative Ophthalmology & Visual Science 49 (4): 1525-1532 (2008-04)



Lohoff F.W.; Lautenschlager M.; Mohr J.; Ferraro T.N.; Sander T.; Gallinat J.
Association between variation in the vesicular monoamine transporter 1 gene on chromosome 8p and anxiety-related personality traits
Neuroscience Letters 434 (1): 41-45 (2008-03-21)



Maerschenz S.; Brinckmann A.; Nuernberg P.; Krueger D.H.; Guenther S.; Meisel H.
Co-replication analyses of naturally occurring defective hepatitis B virus variants with wild-type
Virology 372 (2): 247-259 (2008-03-15)



Pasternack S.M.; von Kuegelgen I.; Aboud K.A.; Lee Y.A.; Rueschendorf F.; Voss K.; Hillmer A.M.; Molderings G.J.; Franz T.; Ramirez A.; Nuernberg P.; Noethen M.M.; Betz R.C.
G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth
Nature Genetics 40 (3): 329-334 (2008-03)



Leistner S.; Huebner N.; Faulstich A.; Ludwig D.; Rees M.; Marx P.; Langer B.; Nikolova A.; Hartmann A.; Koennecke H.C.
Increased prevalence of microangiopathic brain lesions among siblings of patients with lacunar stroke. A prospective multicenter study
European Neurology 59 (3-4): 143-147 (2008-02)



Kayser M.; Lao O.; Saar K.; Brauer S.; Wang X.; Nuernberg P.; Trent R.J.; Stoneking M.
Genome-wide analysis indicates more Asian than Melanesian ancestry of Polynesians
American Journal of Human Genetics 82 (1): 194-198 (2008-01-10)



Tang B.; Sander T.; Craven K.B.; Hempelmann A.; Escayg A.
Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy
Neurobiology of Diseases 29 (1): 59-70 (2008-01)



2007

Schulz F.; Marenholz I.; Foelster-Holst R.; Chen C.; Sternjak A.; Baumgrass R.; Esparza-Gordillo J.; Grueber C.; Nickel R.; Schreiber S.; Stoll M.; Kurek M.; Rueschendorf F.; Huebner N.; Wahn U.; Lee Y.A.
A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczema
Journal of Allergy and Clinical Immunology 120 (5): 1097-1102 (2007-11)



Wenzel K.; Geier C.; Qadri F.; Huebner N.; Schulz H.; Erdmann B.; Gross V.; Bauer D.; Dechend R.; Dietz R.; Osterziel K.J.; Spuler S.; Oezcelik C.
Dysfunction of dysferlin-deficient hearts
Journal of Molecular Medicine 85 (11): 1203-1214 (2007-11)



Gregory-Evans C.Y.; Moosajee M.; Hodges M.D.; Mackay D.S.; Game L.; Vargesson N.; Bloch-Zupan A.; Rueschendorf F.; Santos-Pinto L.; Wackens G.; Gregory-Evans K.
SNP genome scanning localises oto-dental syndrome to chromosome 11q13 and microdeletions at this locus implicate FGF3 in dental and inner ear disease and FADD in ocular coloboma
Human Molecular Genetics 16 (20): 2482-2493 (2007-10-15)



Hoyer J.; Dreweke A.; Becker C.; Goehring I.; Thiel C.T.; Peippo M.M.; Rauch R.; Hofbeck M.; Trautmann U.; Zweier C.; Zenker M.; Hueffmeier U.; Kraus C.; Ekici A.B.; Rueschendorf F.; Nuernberg P.; Reis A.; Rauch A.
Molecular karyotyping in patients with mental retardation using 100K single-nucleotide polymorphism arrays
Journal of Medical Genetics 44 (10): 629-636 (2007-10)



Friedel S.; Saar K.; Sauer S.; Dempfle A.; Walitza S.; Renner T.; Romanos M.; Freitag C.; Seitz C.; Palmason H.; Scherag A.; Windemuth-Kieselbach C.; Schimmelmann B.G.; Wewetzer C.; Meyer J.; Warnke A.; Lesch K.P.; Reinhardt R.; Herpertz-Dahlmann B.; Linder M.; Hinney A.; Remschmidt H.; Schaefer H.; Konrad K.; Huebner N.; Hebebrand J.
Association and linkage of allelic variants of the dopamine transporter gene in ADHD
Molecular Psychiatry 12 (10): 923-933 (2007-10)



Winterer G.; Musso F.; Konrad A.; Vucurevic G.; Stoeter P.; Sander T.; Gallinat J.
Association of attentional network function with exon 5 variations of the CHRNA4 gene
Human Molecular Genetics 16 (18): 2165-2174 (2007-09-15)



Doss M.X.; Chen S.; Winkler J.; Hippler-Altenburg R.; Odenthal M.; Wickenhauser C.; Balaraman S.; Schulz H.; Hummel O.; Huebner N.; Ghosh-Choudhury N.; Sotiriadou I.; Hescheler J.; Sachinidis A.
Transcriptomic and phenotypic analysis of murine embryonic stem cell derived BMP2+ lineage cells: an insight into mesodermal patterning
Genome Biology 8 (9): R184 (2007-09-04)



Soederhaell C.; Marenholz I.; Kerscher T.; Rueschendorf F.; Esparza-Gordillo J.; Worm M.; Gruber C.; Mayr G.; Albrecht M.; Rohde K.; Schulz H.; Wahn U.; Huebner N.; Lee Y.A.
Variants in a novel epidermal collagen gene (COL29A1) are associated with atopic dermatitis
PLoS Biology 5 (9): e242 (2007-09)



Lee-Kirsch M.A.; Gong M.; Chowdhury D.; Senenko L.; Engel K.; Lee Y.A.; de Silva U.; Bailey S.L.; Witte T.; Vyse T.J.; Kere J.; Pfeiffer C.; Harvey S.; Wong A.; Koskenmies S.; Hummel O.; Rohde K.; Schmidt R.E.; Dominiczak A.F.; Gahr M.; Hollis T.; Perrino F.W.; Lieberman J.; Huebner N.
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus
Nature Genetics 39 (9): 1065-1067 (2007-09)



Lang U.E.; Bajbouj M.; Sander T.; Gallinat J.
Gender-dependent association of the functional catechol-O-methyltransferase Val158Met genotype with sensation seeking personality trait
Neuropsychopharmacology 32 (9): 1950-1955 (2007-09)



Everett K.; Chioza B.; Aicardi J.; Aschauer H.; Brouwer O.; Callenbach P.; Covanis A.; Dooley J.; Dulac O.; Durner M.; Eeg-Olofsson O.; Feucht M.; Friis M.; Guerrini R.; Heils A.; Kjeldsen M.; Nabbout R.; Sander T.; Wirrell E.; McKeigue P.; Robinson R.; Taske N.; Gardiner M.
Linkage and mutational analysis of CLCN2 in childhood absence epilepsy
Epilepsy Research 75 (2-3): 145-153 (2007-07)



Kota L.; Osborne-Pellegrin M.; Schulz H.; Behmoaras J.; Coutard M.; Gong M.; Huebner N.
Quantitative genetic basis of arterial phenotypes in the Brown Norway rat
Physiological Genomics 30 (1): 17-25 (2007-06-01)



Lee-Kirsch M.A.; Chowdhury D.; Harvey S.; Gong M.; Senenko L.; Engel K.; Pfeiffer C.; Hollis T.; Gahr M.; Perrino F.W.; Lieberman J.; Huebner N.
A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus
Journal of Molecular Medicine 85 (5): 531-537 (2007-05)



Wenzel K.; Daskalow K.; Herse F.; Seitz S.; Zacharias U.; Schenk J.A.; Schulz H.; Huebner N.; Micheel B.; Schlag P.M.; Osterziel K.J.; Ozcelik C.; Scherneck S.; Jandrig B.
Expression of the protein phosphatase 1 inhibitor KEPI is downregulated in breast cancer cell lines and tissues and involved in the regulation of the tumor suppressor EGR1 via the MEK-ERK pathway
Biological Chemistry 388 (5): 489-495 (2007-05)



Doss M.X.; Winkler J.; Chen S.; Hippler-Altenburg R.; Sotiriadou I.; Halbach M.; Pfannkuche K.; Liang H.; Schulz H.; Hummel O.; Huebner N.; Rottscheidt R.; Hescheler J.; Sachinidis A.
Global transcriptome analysis of murine embryonic stem cell-derived cardiomyocytes
Genome Biology 8 (4): R56 (2007-04-11)



Leach N.T.; Sun Y.; Michaud S.; Zheng Y.; Ligon K.L.; Ligon A.H.; Sander T.; Korf B.R.; Lu W.; Harris D.J.; Gusella J.F.; Maas R.L.; Quade B.J.; Cole A.J.; Kelz M.B.; Morton C.C.
Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice
American Journal of Human Genetics 80 (4): 792-799 (2007-04)



Hempelmann A.; Cobilanschi J.; Heils A.; Muhle H.; Stephani U.; Weber Y.; Lerche H.; Sander T.
Lack of evidence of an allelic association of a functional GABRB3 exon 1a promoter polymorphism with idiopathic generalized epilepsy
Epilepsy Research 74 (1): 28-32 (2007-04)



Cavalleri G.L.; Walley N.M.; Soranzo N.; Mulley J.; Doherty C.P.; Kapoor A.; Depondt C.; Lynch J.M.; Scheffer I.E.; Heils A.; Gehrmann A.; Kinirons P.; Gandhi S.; Satishchandra P.; Wood N.W.; Anand A.; Sander T.; Berkovic S.F.; Delanty N.; Goldstein D.B.; Sisodiya S.M.
A multicenter study of BRD2 as a risk factor for juvenile myoclonic epilepsy
Epilepsia 48 (4): 706-712 (2007-04)



Everett K.V.; Chioza B.; Aicardi J.; Aschauer H.; Brouwer O.; Callenbach P.; Covanis A.; Dulac O.; Eeg-Olofsson O.; Feucht M.; Friis M.; Goutieres F.; Guerrini R.; Heils A.; Kjeldsen M.; Lehesjoki A.E.; Makoff A.; Nabbout R.; Olsson I.; Sander T.; Siren A.; McKeigue P.; Robinson R.; Taske N.; Rees M.; Gardiner M.
Linkage and association analysis of CACNG3 in childhood absence epilepsy
European Journal of Human Genetics 15 (4): 463-472 (2007-04)



Heiser P.; Dempfle A.; Friedel S.; Konrad K.; Hinney A.; Kiefl H.; Walitza S.; Bettecken T.; Saar K.; Linder M.; Warnke A.; Herpertz-Dahlmann B.; Schaefer H.; Remschmidt H.; Hebebrand J.
Family-based association study of serotonergic candidate genes and attention-deficit/hyperactivity disorder in a German sample
Journal of Neural Transmission 114 (4): 513-521 (2007-04)



Lang U.E.; Sander T.; Lohoff F.W.; Hellweg R.; Bajbouj M.; Winterer G.; Gallinat J.
Association of the met66 allele of brain-derived neurotrophic factor (BDNF) with smoking
Psychopharmacology 190 (4): 433-439 (2007-03)



Najmabadi H.; Motazacker M.M.; Garshasbi M.; Kahrizi K.; Tzschach A.; Chen W.; Behjati F.; Hadavi V.; Nieh S.E.; Abedini S.S.; Vazifehmand R.; Firouzabadi S.G.; Jamali P.; Falah M.; Seifati S.M.; Grueters A.; Lenzner S.; Jensen L.R.; Rueschendorf F.; Kuss A.W.; Ropers H.H.
Homozygosity mapping in consanguineous families reveals extreme heterogeneity of non-syndromic autosomal recessive mental retardation and identifies 8 novel gene loci
Human Genetics 121 (1): 43-48 (2007-03)



Lorenz S.; Heils A.; Kasper J.M.; Sander T.
Allelic association of a truncation mutation of the KCNMB3 gene with idiopathic generalized epilepsy
American Journal of Medical Genetics B 144B (1): 10-13 (2007-01-05)



Dietter J.; Mattheisen M.; Fuerst R.; Rueschendorf F.; Wienker T.F.; Strauch K.
Linkage analysis using sex-specific recombination fractions with GENEHUNTER-MODSCORE
Bioinformatics 23 (1): 64-70 (2007-01-01)



Gallinat J.; Goetz T.; Kalus P.; Bajbouj M.; Sander T.; Winterer G.
Genetic variations of the NR3A subunit of the NMDA receptor modulate prefrontal cerebral activity in humans
Journal of Cognitive Neuroscience 19 (1): 59-68 (2007-01)



2006

Lohoff F.W.; Dahl J.P.; Ferraro T.N.; Arnold S.E.; Gallinat J.; Sander T.; Berrettini W.H.
Variations in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) are associated with bipolar I disorder
Neuropsychopharmacology 31 (12): 2739-2747 (2006-12)



Gedicke M.M.; Traupe H.; Fischer B.; Tinschert S.; Hennies H.C.
Towards characterization of palmoplantar keratoderma caused by gain-of-function mutation in loricrin: analysis of a family and review of the literature
British Journal of Dermatology 154 (1): 167-171 (2006-12)



Blaydon D.C.; Ishii Y.; O'Toole E.A.; Unsworth H.C.; Teh M.T.; Rueschendorf F.; Sinclair C.; Hopsu-Havu V.K.; Tidman N.; Moss C.; Watson R.; de Berker D.; Wajid M.; Christiano A.M.; Kelsell D.P.
The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia
Nature Genetics 38 (11): 1245-1247 (2006-11)



Blueher M.; Engeli S.; Kloeting N.; Berndt J.; Fasshauer M.; Batkai S.; Pacher P.; Schoen M.R.; Jordan J.; Stumvoll M.
Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity
Diabetes 55 (11): 3053-3060 (2006-11-01)



Petretto E.; Mangion J.; Dickens N.J.; Cook S.A.; Kumaran M.K.; Lu H.; Fischer J.; Maatz H.; Kren V.; Pravenec M.; Huebner N.; Aitman T.J.
Heritability and tissue specificity of expression quantitative trait loci
PLoS Genetics 2 (10): 1625-1633 (2006-10-20)



Rubattu S.; Huebner N.; Ganten U.; Evangelista A.; Stanzione R.; Angelantonio E.D.; Plehm R.; Langanki R.; Gianazza E.; Sironi L.; D'Amati G.; Volpe M.
Reciprocal congenic lines for a major stroke-QTL on rat chromosome 1
Physiological Genomics 27 (2): 108-113 (2006-10-11)



Hempelmann A.; Taylor K.P.; Heils A.; Lorenz S.; Prud'homme J.F.; Nabbout R.; Dulac O.; Rudolf G.; Zara F.; Bianchi A.; Robinson R.; Gardiner R.M.; Covanis A.; Lindhout D.; Stephani U.; Elger C.E.; Weber Y.G.; Lerche H.; Nuernberg P.; Kron K.L.; Scheffer I.E.; Mulley J.C.; Berkovic S.F.; Sander T.
Exploration of the genetic architecture of idiopathic generalized epilepsies
Epilepsia 47 (10): 1682-1690 (2006-10)



Hempelmann A.; Heils A.; Sander T.
Confirmatory evidence for an association of the connexin-36 gene with juvenile myoclonic epilepsy
Epilepsy Research 71 (2-3): 223-228 (2006-10)



Rauch A.; Hoyer J.; Guth S.; Zweier C.; Kraus C.; Becker C.; Zenker M.; Hueffmeier U.; Thiel C.; Rueschendorf F.; Nuernberg P.; Reis A.; Trautmann U.
Diagnostic yield of various genetic approaches in patients with unexplained developmental delay or mental retardation
American Journal of Medical Genetics A 140A (19): 2063-2074 (2006-10-01)



Lee-Kirsch M.A.; Gong M.; Schulz H.; Rueschendorf F.; Stein A.; Pfeiffer C.; Ballarini A.; Gahr M.; Huebner N.; Linne M.
Familial chilblain lupus, a monogenic form of cutaneous lupus erythematosus, maps to chromosome 3p
American Journal of Human Genetics 79 (4): 731-737 (2006-10)



Marenholz I.; Nickel R.; Rueschendorf F.; Schulz F.; Esparza-Gordillo J.; Kerscher T.; Grueber C.; Lau S.; Worm M.; Keil T.; Kurek M.; Zaluga E.; Wahn U.; Lee Y.A.
Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march
Journal of Allergy and Clinical Immunology 118 (4): 866-871 (2006-10)



Steffens M.; Lamina C.; Illig T.; Bettecken T.; Vogler R.; Entz P.; Suk E.K.; Toliat M.R.; Klopp N.; Caliebe A.; Koenig I.R.; Koehler K.; Luedemann J.; Lacava A.D.; Fimmers R.; Lichtner P.; Ziegler A.; Wolf A.; Krawczak M.; Nuernberg P.; Hampe J.; Schreiber S.; Meitinger T.; Wichmann H.E.; Roeder K.; Wienker T.F.; Baur M.P.
SNP-Based analysis of genetic substructure in the German population
Human Heredity 62 (1): 20-29 (2006-10)



Dempfle A.; Wudy S.A.; Saar K.; Hagemann S.; Friedel S.; Scherag A.; Berthold L.D.; Alzen G.; Gortner L.; Blum W.F.; Hinney A.; Nuernberg P.; Schaefer H.; Hebebrand J.
Evidence for involvement of the vitamin D receptor gene in idiopathic short stature via a genome-wide linkage study and subsequent association studies
Human Molecular Genetics 15 (18): 2772-2783 (2006-09-15)



Maerschenz S.; Endres A.S.; Brinckmann A.; Heise T.; Kristiansen G.; Nuernberg P.; Krueger D.H.; Guenther S.; Meisel H.
Functional analysis of complex hepatitis B virus variants associated with development of liver cirrhosis
Gastroenterology 131 (3): 765-780 (2006-09)



Petretto E.; Mangion J.; Cook S.A.; Aitman T.J.; Pravenec M.; Schulz H.; Fischer J.; Huebner N.
Reply to "Normalization procedures and detection of linkage signal in genetical-genomics experiments"
Nature Genetics 38 (8): 858-859 (2006-08)



Kirchheiner J.; Lang U.; Stamm T.; Sander T.; Gallinat J.
Association of CYP2D6 genotypes and personality traits in healthy individuals
Journal of Clinical Psychopharmacology 26 (4): 440-442 (2006-08)



Guryev V.; Smits B.M.; van de Belt J.; Verheul M.; Huebner N.; Cuppen E.
Haplotype block structure is conserved across mammals
PLoS Genetics 2 (7): 1111-1118 (2006-07-28)



Hempelmann A.; Kumar S.; Muralitharan S.; Sander T.
Myofibrillogenesis regulator 1 gene (MR-1) mutation in an Omani family with paroxysmal nonkinesigenic dyskinesia
Neuroscience Letters 402 (1-2): 118-120 (2006-07-10)



von Brevern M.; Ta N.; Shankar A.; Wiste A.; Siegel A.; Radtke A.; Sander T.; Escayg A.
Migrainous vertigo: mutation analysis of the candidate genes CACNA1A, ATP1A2, SCN1A, and CACNB4
Headache 46 (7): 1136-1141 (2006-07)



Entz P.; Blaumeiser B.; Betz R.C.; Lambert J.; Seymons K.; Eigelshoven S.; Hanneken S.; Kruse R.; Nuernberg P.; Nagy M.; Noethen M.M.
Investigation of the HLA-DRB1 locus in alopecia areata
European Journal of Dermatology 16 (4): 363-367 (2006-07)



Wolf M.T.; Mucha B.E.; Hennies H.C.; Attanasio M.; Panther F.; Zalewski I.; Karle S.M.; Otto E.A.; Deltas C.C.; Fuchshuber A.; Hildebrandt F.
Medullary cystic kidney disease type 1: mutational analysis in 37 genes based on haplotype sharing
Human Genetics 119 (6): 649-658 (2006-07)



Todt I.; Hennies H.C.; Kuester W.; Smolle J.; Rademacher G.; Mutze S.; Basta D.; Eisenschenk A.; Ernst A.
Neurotological and neuroanatomical changes in the connexin-26-related HID/KID syndrome
Audiology & Neuro-Otology 11 (4): 242-248 (2006-06)



Petretto E.; Mangion J.; Pravanec M.; Huebner N.; Aitman T.J.
Integrated gene expression profiling and linkage analysis in the rat
Mammalian Genome 17 (6): 480-489 (2006-06)



Lorenz S.; Taylor K.P.; Gehrmann A.; Becker T.; Muhle H.; Gresch M.; Tauer U.; Sander T.; Stephani U.
Association of BRD2 polymorphisms with photoparoxysmal response
Neuroscience Letters 400 (1-2): 135-139 (2006-05-29)



Vanita V.; Singh J.R.; Hejtmancik J.F.; Nuernberg P.; Hennies H.C.; Singh D.; Sperling K.
A novel fan-shaped cataract-microcornea syndrome caused by a mutation of CRYAA in an Indian family
Molecular Vision 12: 518-522 (2006-05-22)



Chioza B.; Everett K.; Aschauer H.; Brouwer O.; Callenbach P.; Covanis A.; Dulac O.; Durner M.; Eeg-Olofsson O.; Feucht M.; Friis M.; Heils A.; Kjeldsen M.; Larsson K.; Lehesjoki A.E.; Nabbout R.; Olsson I.; Sander T.; Siren A.; Robinson R.; Rees M.; Gardiner R.M.
Evaluation of CACNA1H in European patients with childhood absence epilepsy
Epilepsy Research 69 (2): 177-181 (2006-05)



Lorenz S.; Heils A.; Taylor K.P.; Gehrmann A.; Muhle H.; Gresch M.; Becker T.; Tauer U.; Stephani U.; Sander T.
Candidate gene analysis of the succinic semialdehyde dehydrogenase gene (ALDH5A1) in patients with idiopathic generalized epilepsy and photosensitivity
Neuroscience Letters 397 (3): 234-239 (2006-04-24)



Ciana G.; Trappan A.; Bembi B.; Benettoni A.; Maso G.; Zennaro F.; Ruf N.; Schnabel D.; Rutsch F.
Generalized arterial calcification of infancy: two siblings with prolonged survival
European Journal of Pediatrics 165 (4): 258-263 (2006-04)



Gong M.; Huebner N.
Molecular genetics of human hypertension
Clinical Science 110 (3): 315-326 (2006-03)



Vanita V.; Hejtmancik J.F.; Hennies H.C.; Guleria K.; Nuernberg P.; Singh D.; Sperling K.; Singh J.R.
Sutural cataract associated with a mutation in the ferritin light chain gene (FTL) in a family of Indian origin
Molecular Vision 12: 93-99 (2006-02-21)



Garshasbi M.; Motazacker M.M.; Kahrizi K.; Behjati F.; Abedini S.S.; Nieh S.E.; Firouzabadi S.G.; Becker C.; Rueschendorf F.; Nuernberg P.; Tzschach A.; Vazifehmand R.; Erdogan F.; Ullmann R.; Lenzner S.; Kuss A.W.; Ropers H.H.; Najmabadi H.
SNP array-based homozygosity mapping reveals MCPH1 deletion in family with autosomal recessive mental retardation and mild microcephaly
Human Genetics 118 (6): 708-715 (2006-02)



Hebebrand J.; Dempfle A.; Saar K.; Thiele H.; Herpertz-Dahlmann B.; Linder M.; Kiefl H.; Remschmidt H.; Hemminger U.; Warnke A.; Knoelker U.; Heiser P.; Friedel S.; Hinney A.; Schaefer H.; Nuernberg P.; Konrad K.
A genome-wide scan for attention-deficit/hyperactivity disorder in 155 german sib-pairs
Molecular Psychiatry 11 (2): 196-205 (2006-02)



Huebner N.
Expressing physiology
Nature Genetics 38 (2): 140-141 (2006-02)



Fehr C.; Sander T.; Tadic A.; Lenzen K.P.; Anghelescu I.; Klawe C.; Dahmen N.; Schmidt L.G.; Szegedi A.
Confirmation of association of the GABRA2 gene with alcohol dependence by subtype-specific analysis
Psychiatric Genetics 16 (1): 9-17 (2006-02)



Mathas S.; Janz M.; Hummel F.; Hummel M.; Wollert-Wulf B.; Lusatis S.; Anagnostopoulos I.; Lietz A.; Sigvardsson M.; Jundt F.; Joehrens K.; Bommert K.; Stein H.; Doerken B.
Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma
Nature Immunology 7 (2): 207-215 (2006-02)



Stadt U.Z.; Beutel K.; Kolberg S.; Schneppenheim R.; Kabisch H.; Janka G.; Hennies H.C.
Mutation spectrum in children with primary hemophagocytic lymphohistiocytosis: molecular and functional analyses of PRF1, UNC13D, STX11, and RAB27A
Human Mutation 27 (1): 62-68 (2006-01)



Zimdahl H.; Huebner N.
Gene chip technology and its application to molecular medicine
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 1 : 650-655 (2006)



Schirmer M.; Toliat M.R.; Haberl M.; Suk A.; Kamdem L.K.; Klein K.; Brockmoeller J.; Nuernberg P.; Zanger U.M.; Wojnowski L.
Genetic signature consistent with selection against the CYP3A4*1B allele in non-African populations
Pharmacogenetics and Genomics 16 (1): 59-71 (2006-01)



Zheng W.; Rosenstiel P.; Huse K.; Sina C.; Valentonyte R.; Mah N.; Zeitlmann L.; Grosse J.; Ruf N.; Nuernberg P.; Costello C.M.; Onnie C.; Mathew C.; Platzer M.; Schreiber S.; Hampe J.
Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease
Genes and Immunity 7: 11-18 (2006-01)



Huebner N.; Yagil C.; Yagil Y.
Novel integrative approaches to the identification of candidate genes in hypertension
Hypertension 47 (1): 1-5 (2006-01)



Gong M.; Huebner N.
Gene variants, nutritional parameters, and hypertension
Nutritional Genomics: Impact on Health and Disease : 327-354 (2006)



2005

Strauch K.; Fuerst R.; Rueschendorf F.; Windemuth C.; Dietter J.; Flaquer A.; Baur M.P.; Wienker T.F.
Linkage analysis of alcohol dependence using MOD scores
BMC Genetics 6 (Suppl 1): S162 (2005-12-30)



Lohoff F.W.; Sander T.; Ferraro T.N.; Dahl J.P.; Gallinat J.; Berrettini W.H.
Confirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder
American Journal of Medical Genetics B 139 (1): 51-53 (2005-11-05)



Thiel C.T.; Horn D.; Zabel B.; Ekici A.B.; Salinas K.; Gebhart E.; Rueschendorf F.; Sticht H.; Spranger J.; Mueller D.; Zweier C.; Schmitt M.E.; Reis A.; Rauch A.
Severely incapacitating mutations in patients with extreme short stature identify RNA-processing endoribonuclease RMRP as an essential cell growth regulator
American Journal of Human Genetics 77 (5): 795-806 (2005-11-01)



Wenzel K.; Zabojszcza J.; Carl M.; Taubert S.; Lass A.; Harris C.L.; Ho M.; Schulz H.; Hummel O.; Huebner N.; Osterziel K.J.; Spuler S.
Increased susceptibility to complement attack due to down-regulation of decay-accelerating factor/CD55 in dysferlin-deficient muscular dystrophy
Journal of Immunology 175 (9): 6219-6225 (2005-11-01)



Lenzen K.P.; Heils A.; Lorenz S.; Hempelmann A.; Sander T.
Association analysis of malic enzyme 2 gene polymorphisms with idiopathic generalized epilepsy
Epilepsia 46 (10): 1637-1641 (2005-10-01)



Hammes A.; Andreassen T.K.; Spoelgen R.; Raila J.; Huebner N.; Schulz H.; Metzger J.; Schweigert F.J.; Luppa P.B.; Nykjaer A.; Willnow T.E.
Role of endocytosis in cellular uptake of sex steroids
Cell 122 (5): 751-762 (2005-09-09)



Gu W.; Sander T.; Heils A.; Lenzen K.P.; Steinlein O.K.
A new EF-hand containing gene EFHC2 on Xp11.4: Tentative evidence for association with juvenile myoclonic epilepsy
Epilepsy Research 66 (1-3): 91-98 (2005-08-18)



Schmitt B.; Wohlrab G.; Sander T.; Steinlein O.K.; Hajnal B.L.
Neonatal seizures with tonic clonic sequences and poor developmental outcome
Epilepsy Research 65 (3): 161-168 (2005-07-01)



Lenzen K.P.; Heils A.; Lorenz S.; Hempelmann A.; Sander T.
Association analysis of the Arg220His variation of the human gene encoding the GABA delta subunit with idiopathic generalized epilepsy
Epilepsy Research 65 (1-2): 53-57 (2005-06)



Huebner N.; Wallace C.A.; Zimdahl H.; Petretto E.; Schulz H.; Maciver F.; Mueller M.; Hummel O.; Monti J.; Zidek V.; Musilova A.; Kren V.; Causton H.; Game L.; Born G.; Schmidt S.; Mueller A.; Cook S.A.; Kurtz T.W.; Whittaker J.; Pravenec M.; Aitman T.J.
Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease
Nature Genetics 37 (3): 243-253 (2005-03-01)



Reinhard C.; Meyer B.; Fuchs H.; Stoeger T.; Eder G.; Rueschendorf F.; Heyder J.; Nuernberg P.; Hrabe de Angelis M.; Schulz H.
Genomewide linkage analysis identifies novel genetic loci for lung function in mice
American Journal of Respiratory and Critical Care Medicine 171: 880-888 (2005-01-07)



Altmueller J.; Seidel C.; Lee Y.A.; Loesgen S.; Bulle D.; Friedrichs F.; Jellouschek H.; Kelber J.; Keller A.; Schuster A.; Silbermann M.; Wahlen W.; Wolff P.; Rueschendorf F.; Schlenvoigt G.; Nuernberg P.; Wjst M.
Phenotypic and genetic heterogeneity in a genome-wide linkage study of asthma families
BMC Pulmonary Medicine 5: 1 (2005-01-05)



Tauer U.; Lorenz S.; Lenzen K.P.; Heils A.; Muhle H.; Gresch M.; Neubauer B.A.; Waltz S.; Rudolf G.; Mattheisen M.; Strauch K.; Schmitz B.; Stephani U.; Sander T.
Genetic dissection of photosensitivity and its relation to idiopathic generalized epilepsy
Annals of Neurology 57 (6): 866-873 (2005-01-01)



Kurz T.; Altmueller J.; Strauch K.; Rueschendorf F.; Heinzmann A.; Moffatt M.F.; Cookson W.O.C.M.; Inacio F.; Nuernberg P.; Stassen H.H.; Deichmann K.A.
A genome-wide screen on the genetics of atopy in a multiethnic European population reveals a major atopy locus on chromosome 3q21.3
Allergy 60: 192-199 (2005-01-01)



Yagil C.; Huebner N.; Monti J.; Schulz H.; Sapojnikov M.; Luft F.C.; Ganten D.; Yagil Y.
Identification of hypertension-related genes through an integrated genomic-transcriptomic approach
Circulation Research 96 (6): 617-625 (2005-01-01)



Metherell L.A.; Chapple J.P.; Cooray S.; David A.; Becker C.; Rueschendorf F.; Naville D.; Begeot M.; Khoo B.; Nuernberg P.; Huebner A.; Cheetham M.E.; Clark A.J.L.
Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2
Nature Genetics 37 (2): 166-170 (2005-01-01)



Lang U.E.; Hellweg R.; Kalus P.; Bajbouj M.; Lenzen K.P.; Sander T.; Kunz D.; Gallinat J.
Association of a functional BDNF polymorphism and anxiety-related personality traits
Psychopharmacology 180 (1): 95-99 (2005-01-01)



Lenzen K.P.; Heils A.; Lorenz S.; Hempelmann A.; Hoefels S.; Lohoff F.W.; Schmitz B.; Sander T.
Supportive evidence for an allelic association of the human KCNJ10 potassium channel gene with idiopathic generalized epilepsy
Epilepsy Research 63 (2): 113-118 (2005-01-01)



Rueschendorf F.; Nuernberg P.
ALOHOMORA: a tool for linkage analysis using 10K SNP array data
Bioinformatics 21: 2123-2125 (2005-01-01)



2004

Uhlenberg B.; Schuelke M.; Rueschendorf F.; Ruf N.; Kaindl A.M.; Henneke M.; Thiele H.; Stoltenburg-Didinger G.; Aksu F.; Topaloglu H.; Nuernberg P.; Huebner C.; Weschke B.; Gaertner J.
Mutations in the gene encoding gap junction protein alpha 12 (connexin 46.6) cause Pelizaeus-Merzbacher-like disease
American Journal of Human Genetics 75 (2): 251-260 (2004-08)



Gibbs R.A.; Weinstock G.M.; Metzker M.L.; Muzny D.M.; Sodergren E.J.; Scherer S.; Scott G.; Steffen D.; Worley K.C.; Burch P.E.; Okwuonu G.; Hines S.; Lewis L.; DeRamo C.; Delgado O.; Dugan-Rocha S.; Miner G.; Morgan M.; Hawes A.; Gill R.; Holt R.A.; Adams M.D.; Amanatides P.G.; Baden-Tillson H.; Barnstead M.; Chin S.; Evans C.A.; Ferriera S.; Fosler C.; Glodek A.; Gu Z.; Jennings D.; Kraft C.L.; Nguyen T.; Pfannkoch C.M.; Sitter C.; Sutton G.G.; Venter J.C.; Woodage T.; Smith D.; Lee H.M.; Gustafson E.; Cahill P.; Kana A.; Doucette-Stamm L.; Weinstock K.; Fechtel K.; Weiss R.B.; Dunn D.M.; Green E.D.; Blakesley R.W.; Bouffard G.G.; de Jong P.J.; Osoegawa K.; Zhu B.; Marra M.; Schein J.; Bosdet I.; Fjell C.; Jones S.; Krzywinski M.; Mathewson C.; Siddiqui A.; Wye N.; McPherson J.; Zhao S.; Fraser C.M.; Shetty J.; Shatsman S.; Geer K.; Chen Y.; Abramzon S.; Nierman W.C.; Havlak P.H.; Chen R.; Durbin K.J.; Egan A.; Ren Y.; Song X.Z.; Li B.; Liu Y.; Qin X.; Cawley S.; Worley K.C.; Cooney A.J.; D'Souza L.M.; Martin K.; Wu J.Q.; Gonzalez-Garay M.L.; Jackson A.R.; Kalafus K.J.; McLeod M.P.; Milosavljevic A.; Virk D.; Volkov A.; Wheeler D.A.; Zhang Z.; Bailey J.A.; Eichler E.E.; Tuzun E.; Birney E.; Mongin E.; Ureta-Vidal A.; Woodwark C.; Zdobnov E.; Bork P.; Suyama M.; Torrents D.; Alexandersson M.; Trask B.J.; Young J.M.; Huang H.; Wang H.; Xing H.; Daniels S.; Gietzen D.; Schmidt J.; Stevens K.; Vitt U.; Wingrove J.; Camara F.; Alba M.M.; Abril J.F.; Guigo R.; Smit A.; Dubchak I.; Rubin E.M.; Couronne O.; Poliakov A.; Huebner N.; Ganten D.; Goesele C.; Hummel O.; Kreitler T.; Lee Y.A.; Monti J.; Schulz H.; Zimdahl H.; Himmelbauer H.; Lehrach H.; Jacob H.J.; Bromberg S.; Gullings-Handley J.; Jensen-Seaman M.I.; Kwitek A.E.; Lazar J.; Pasko D.; Tonellato P.J.; Twigger S.; Ponting C.P.; Duarte J.M.; Rice S.; Goodstadt L.; Beatson S.A.; Emes R.D.; Winter E.E.; Webber C.; Brandt P.; Nyakatura G.; Adetobi M.; Chiaromonte F.; Elnitski L.; Eswara P.; Hardison R.C.; Hou M.; Kolbe D.; Makova K.; Miller W.; Nekrutenko A.; Riemer C.; Schwartz S.; Taylor J.; Yang S.; Zhang Y.; Lindpaintner K.; Andrews T.D.; Caccamo M.; Clamp M.; Clarke L.; Curwen V.; Durbin R.; Eyras E.; Searle S.M.; Cooper G.M.; Batzoglou S.; Brudno M.; Sidow A.; Stone E.A.; Venter J.C.; Payseur B.A.; Bourque G.; Lopez-Otin C.; Puente X.S.; Chakrabarti K.; Chatterji S.; Dewey C.; Pachter L.; Bray N.; Yap V.B.; Caspi A.; Tesler G.; Pevzner P.A.; Haussler D.; Roskin K.M.; Baertsch R.; Clawson H.; Furey T.S.; Hinrichs A.S.; Karolchik D.; Kent W.J.; Rosenbloom K.R.; Trumbower H.; Weirauch M.; Cooper D.N.; Stenson P.D.; Ma B.; Brent M.; Arumugam M.; Shteynberg D.; Copley R.R.; Taylor M.S.; Riethman H.; Mudunuri U.; Peterson J.; Guyer M.; Felsenfeld A.; Old S.; Mockrin S.; Collins F.
Genome sequence of the Brown Norway rat yields insights into mammalian evolution
Nature 428 (6982): 493-521 (2004-04-01)



Krzywinski M.; Wallis J.; Goesele C.; Bosdet I.; Chiu R.; Graves T.; Hummel O.; Layman D.; Mathewson C.; Wye N.; Zhu B.; Albracht D.; Asano J.; Barber S.; Brown-John M.; Chan S.; Chand S.; Cloutier A.; Davito J.; Fjell C.; Gaige T.; Ganten D.; Girn N.; Guggenheimer K.; Himmelbauer H.; Kreitler T.; Leach S.; Lee D.; Lehrach H.; Mayo M.; Mead K.; Olson T.; Pandoh P.; Prabhu A.L.; Shin H.; Taenzer S.; Thompson J.; Tsai M.; Walker J.; Yang G.; Sekhon M.; Hillier L.; Zimdahl H.; Marziali A.; Osoegawa K.; Zhao S.; Siddiqui A.; de Jong P.J.; Warren W.; Mardis E.; McPherson J.D.; Wilson R.; Huebner N.; Jones S.; Marra M.; Schein J.
Integrated and sequence-ordered BAC- and YAC-based physical maps for the rat genome
Genome Research 14 (4): 766-779 (2004-04)



Janecke A.R.; Thompson D.A.; Utermann G.; Becker C.; Huebner C.A.; Schmid E.; McHenry C.L.; Nair A.R.; Rueschendorf F.; Heckenlively J.; Wissinger B.; Nuernberg P.; Gal A.
Mutations in RDH12 encoding a photoreceptor cell retinol dehydrogenase cause childhood-onset severe retinal dystrophy
Nature Genetics 36 (8): 850-854 (2004-01-01)



Rauch A.; Rueschendorf F.; Huang J.; Trautmann U.; Becker C.; Thiel C.; Jones K.W.; Reis A.; Nuernberg P.
Molecular karyotyping using an SNP array for genomewide genotyping
Journal of Medical Genetics 41 (12): 916-922 (2004-01-01)



Bayer Y.; Neumann S.; Meyer B.; Rueschendorf F.; Reske A.; Brix T.; Hegedues L.; Langer P.; Nuernberg P.; Paschke R.
Genome-wide linkage analysis reveals evidence for four new susceptibility loci for familial euthyroid goiter
Journal of Clinical Endocrinology and Metabolism 89 (8): 4044-4052 (2004-01-01)



Zimdahl H.; Nyakatura G.; Brandt P.; Schulz H.; Hummel O.; Fartmann B.; Brett D.; Droege M.; Monti J.; Lee Y.A.; Sun Y.Y.; Zhao S.Y.; Winter E.E.; Ponting C.P.; Chen Y.; Kasprzyk A.; Birney E.; Ganten D.; Huebner N.
A SNP map of the rat genome generated from cDNA sequences
Science 303 (5659): 807-807 (2004-01-01)



Kaindl A.M.; Rueschendorf F.; Krause S.; Goebel H.H.; Koehler K.; Becker C.; Pongratz D.; Mueller-Hoecker J.; Nuernberg P.; Stoltenburg-Didinger G.; Lochmueller H.; Huebner A.
Missense mutations of ACTA1 cause dominant congenital myopathy with cores
Journal of Medical Genetics 41 (11): 842-848 (2004-01-01)



Liska F.; Goesele C.; Kren V.; Huebner N.; Krenova D.
Molecular analysis of the sex hormone-binding globulin gene in the rat hypodactylous mutation (Hd)
Folia Biologica Prague 50 (2): 63-68 (2004-01-01)



Metherell L.A.; Cooray S.; Huebner A.; Rueschendorf F.; Naville D.; Begeot M.; Clark A.J.L.
Mutations in a novel gene, encoding a single transmembrane domain protein are associated with familial glucocorticoid deficiency type 2
Endocrine Research 30 (4): 889-890 (2004-01-01)



Zechner U.; Shi W.; Hemberger M.; Himmelbauer H.; Otto S.; Orth A.; Kalscheuer V.; Fischer U.; Elango R.; Reis A.; Vogel W.; Ropers H.; Rueschendorf F.; Fundele R.
Divergent genetic and epigenetic post-zygotic isolation mechanisms in Mus and Peromyscus
Journal of Evolutionary Biolog 17 (2): 453-460 (2004-01-01)



2003

Gong M.; Zhang H.Y.; Schulz H.; Lee Y.A.; Sun K.; Baehring S.; Luft F.C.; Nuernberg P.; Reis A.; Rohde K.; Ganten D.; Hui R.T.; Huebner N.
Genome-wide linkage reveals a locus for human essential (primary) hypertension on chromosome 12p
Human Molecular Genetics 12 (11): 1273-1277 (2003-06-01)



Kazmierski S.T.; Antin P.B.; Witt C.C.; Huebner N.; McElhinny A.S.; Labeit S.; Gregorio C.C.
The complete mouse nebulin gene sequence and the identification of cardiac nebulin
Journal of Molecular Biology 328 (4): 835-846 (2003-05-01)



Monti J.; Zimdahl H.; Schulz H.; Plehm R.; Ganten D.; Huebner N.
The role of Wnk4 in polygenic hypertension - A candidate gene analysis on rat chromosome 10
Hypertension 41 (4): 938-942 (2003-04)



Gotthardt M.; Hammer R.E.; Huebner N.; Monti J.; Witt C.C.; McNabb M.; Richardson J.A.; Granzier H.; Labeit S.; Herz J.
Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure
Journal of Biological Chemistry 278 (8): 6059-6065 (2003-02-21)



Monti J.; Plehm R.; Schulz H.; Ganten D.; Kreutz R.; Huebner N.
Interaction between blood pressure quantitative trait loci in rats in which trait variation at chromosome 1 is conditional upon a specific allele at chromosome 10
Human Molecular Genetics 12 (4): 435-439 (2003-01-01)



Yagil C.; Huebner N.; Kreutz R.; Ganten D.; Yagil Y.
Congenic strains confirm the presence of salt-sensitivity QTLs on chromosome 1 in the Sabra rat model of hypertension
Physiological Genomics 12: 85-95 (2003-01-01)



2002

Oezcelik C.; Erdmann B.; Pilz B.; Wettschureck N.; Britsch S.; Huebner N.; Chien K.R.; Birchmeier C.; Garratt A.N.
Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy
Proceedings of the National Academy of Sciences of the United States of America 99 (13): 8880-8885 (2002-06-25)



Zimdahl H.; Kreitler T.; Goesele C.; Ganten D.; Huebner N.
Conserved synteny in rat and mouse for a blood pressure QTL on human chromosome 17
Hypertension 39 (6): 1050-1052 (2002-06-01)



Barta P.; Monti J.; Maass P.G.; Gorzelniak K.; Mueller D.N.; Dechend R.; Luft F.C.; Huebner N.; Sharma A.M.
A gene expression analysis in rat kidney following high and low salt intake
Journal of Hypertension 20: 1115-1120 (2002-01-01)



Kreutz R.; Huebner N.
Congenic rat strains are important tools for the genetic dissection of essential hypertension
Seminars in Nephrology 22 (2): 135-147 (2002-01-01)



2001

Monti J.; Gross V.; Luft F.C.; Milia A.F.; Schulz H.; Dietz R.; Sharma A.M.; Huebner N.
Expression analysis using oligonucleotide microarrays in mice lacking bradykinin type 2 receptors
Hypertension 38 (1): E1-E3 (2001-01-01)



1999

Huebner N.; Lee Y.A.; Lindpaintner K.; Ganten D.; Kreutz R.
Congenic substitution mapping excludes Sa as a candidate gene locus for a blood pressure quantitative trait locus on rat chromosome 1
Hypertension 34: 643-648 (1999-01-01)



1997

Lee M.A.; Cai L.; Huebner N.; Lee Y.A.; Lindpaintner K.
Tissue and development specific expression of multiple alternatively spliced transcripts of rat neuronal nitric oxide synthase
Journal of Clinical Investigation 100 (6): 1507-1512 (1997-09-15)



Kreutz R.; Stock P.; Struk B.; Huebner N.; Ganten D.; Lindpaintner K.
Evidence for primary genetic determination of heart rate regulation. Chromosomal mapping of a genetic locus in the rat
Circulation 96 (4): 1078-1081 (1997-08-19)



Kreutz R.; Struk S.; Rubattu S.; Huebner N.; Szpirer J.; Szpirer C.; Ganten D.; Lindpaintner K.
Role of the alpha, beta, and gamma subunits of epithelial sodium channel in a model of polygenic hypertension
Hypertension 29: 131-136 (1997-01-01)



Brenin D.R.; Look J.; Bader M.; Huebner N.; Levan G.; Iannaccone P.
Rat embryonic stem cells: a progress report
Transplantation Proceedings 29: 1761-1765 (1997-01-01)



Huebner N.; Lee Y.A.; Kreutz R.; Lindpaintner K.; Ganten D.
The stroke-prone spontaneously hypertensive rat and its role in the genetic dissection of cardiovascular disease
Nutrition and Stroke : 87-99 (1997-01-01)



1995

Kreutz R.; Huebner N.; Ganten D.; Lindpaintner K.
Genetic linkage of the ACE gene to plasma angiotensin-converting enzyme activity but not to blood pressure: a quantitative trait locus confers identical complex phenotypes in human and rat hypertension
Circulation 92 (9): 2381-2384 (1995-11-01)



Kreutz R.; Huebner N.; James M.R.; Bihoreau M.T.; Gauguier D.; Lathrop G.M.; Ganten D.; Lindpaintner K.
Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10
Proceedings of the National Academy of Sciences of the United States of America 92 (19): 8778-8782 (1995-09-12)



Huebner N.; Kreutz R.; Rubattu S.; Lee Y.A.; Ganten D.; Allen P.D.; Lindpaintner K.
The gene encoding endothelial nitric oxide synthase, Nos3, maps to rat chromosome 4
Mammalian Genome 6 (10): 758-759 (1995-01-01)



Huebner N.; Ganten D.
Genetics in arterial hypertension - clinical and experimental aspects
Herz 20: 309-314 (1995-01-01)



Huebner N.; Kreutz R.; Takahashi S.; Ganten D.; Lindpaintner K.
Altered angiotensinogen amino acid sequence and plasma angiotensin II levels in genetically hypertensive rats: a study on cause and effects
Hypertension 26: 279-284 (1995-01-01)



Lee Y.A.; Huebner N.; Ganten D.
Genetische Analyse des Bluthochdrucks
Jahrbuch 1995 der Deutschen Akademie der Naturforscher Leopoldina (Halle/Saale) : 323-333 (1995-01-01)



1994

Kreutz R.; Huebner N.; Ganten D.; Lindpaintner K.
Bluthochdruck. Die beteiligten Gene und ihre Bedeutung
Wieviel Genetik braucht der Mensch : 239-252 (1994-01-01)



Huebner N.; Kreutz R.; Takahashi S.; Ganten D.; Lindpaintner K.
Unlike human hypertension, blood pressure in a hereditary hypertensive rat strain shows no linkage to the angiotensinogen locus
Hypertension 23: 797-801 (1994-01-01)