Publications



2017

Krieger K.; Millar S.E.; Mikuda N.; Krahn I.; Kloepper J.E.; Bertolini M.; Scheidereit C.; Paus R.; Schmidt-Ullrich R.
NF-{kappa}B participates in mouse hair cycle control and plays distinct roles in the various pelage hair follicle types
Journal of Investigative Dermatology : (2017-09-20)



Stone S.; Jamison S.; Yue Y.; Durose W.; Schmidt-Ullrich R.; Lin W.
NF-{kappa}B activation protects oligodendrocytes against inflammation
Journal of Neuroscience 37 (38): 9332-9344 (2017-09-20)



Choi M.; Schreiber A.; Eulenberg-Gustavus C.; Scheidereit C.; Kamps J.; Kettritz R.
Endothelial NF-{kappa}B blockade abrogates ANCA-induced GN
Journal of the American Society of Nephrology : (2017-07-07)



Riemann M.; Andreas N.; Fedoseeva M.; Meier E.; Weih D.; Freytag H.; Schmidt-Ullrich R.; Klein U.; Wang Z.Q.; Weih F.
Central immune tolerance depends on crosstalk between the classical and alternative NF-{kappa}B pathways in medullary thymic epithelial cells
Journal of Autoimmunity 81: 56-67 (2017-07)



2016

Schreiber A.; Choi M.
ANCA-associated vasculitis and the mechanisms of tissue injury
Systemic Vasculitides: Current Status and Perspectives : 141-158 (2016-10-14)



Kawasaki M.; Kawasaki K.; Oommen S.; Blackburn J.; Watanabe M.; Nagai T.; Kitamura A.; Maeda T.; Liu B.; Schmidt-Ullrich R.; Akiyama T.; Inoue J.I.; Hammond N.L.; Sharpe P.T.; Ohazama A.
Regional regulation of filiform tongue papillae development by Ikk{alpha}/Irf6
Developmental Dynamics 245 (9): 937-946 (2016-09)



Marko L.; Vigolo E.; Hinze C.; Park J.K.; Roel G.; Balogh A.; Choi M.; Wuebken A.; Cording J.; Blasig I.E.; Luft F.C.; Scheidereit C.; Schmidt-Ott K.M.; Schmidt-Ullrich R.; Mueller D.N.
Tubular epithelial NF-{kappa}B activity regulates ischemic AKI
Journal of the American Society of Nephrology 27 (9): 2658-2669 (2016-09)



Tomann P.; Paus R.; Millar S.E.; Scheidereit C.; Schmidt-Ullrich R.
LHX2 is a direct NF-{kappa}B target gene that promotes primary hair follicle placode down-growth
Development 143 (9): 1512-1522 (2016-05-01)



de Oliveira K.A.P.; Kaergel E.; Heinig M.; Fontaine J.F.; Patone G.; Muro E.M.; Mathas S.; Hummel M.; Andrade-Navarro M.A.; Huebner N.; Scheidereit C.
A roadmap of constitutive NF-{kappa}B activity in Hodgkin lymphoma: dominant roles of p50 and p52 revealed by genome-wide analyses
Genome Medicine 8 (1): 28 (2016-03-17)



2015

Voutilainen M.; Lindfors P.H.; Trela E.; Loennblad D.; Shirokova V.; Elo T.; Rysti E.; Schmidt-Ullrich R.; Schneider P.; Mikkola M.L.
Ectodysplasin/NF-{kappa}B promotes mammary cell fate via Wnt/{beta}-catenin pathway
PLoS Genetics 11 (11): e1005676 (2015-11-18)



Oden F.; Marino S.F.; Brand J.; Scheu S.; Kriegel C.; Olal D.; Takvorian A.; Westermann J.; Yilmaz B.; Hinz M.; Daumke O.; Hoepken U.E.; Mueller G.; Lipp M.
Potent anti-tumor response by targeting B cell maturation antigen (BCMA) in a mouse model of multiple myeloma
Molecular Oncology 9 (7): 1348-1358 (2015-08)



Murakawa Y.; Hinz M.; Mothes J.; Schuetz A.; Uhl M.; Wyler E.; Yasuda T.; Mastrobuoni G.; Friedel C.C.; Doelken L.; Kempa S.; Schmidt-Supprian M.; Bluethgen N.; Backofen R.; Heinemann U.; Wolf J.; Scheidereit C.; Landthaler M.
RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-{kappa}B pathway
Nature Communications 6: 7367 (2015-07-14)



Zandi S.; Nakao S.; Chun K.H.; Fiorina P.; Sun D.; Arita R.; Zhao M.; Kim E.; Schueller O.; Campbell S.; Taher M.; Melhorn M.I.; Schering A.; Gatti F.; Tezza S.; Xie F.; Vergani A.; Yoshida S.; Ishikawa K.; Yamaguchi M.; Sasaki F.; Schmidt-Ullrich R.; Hata Y.; Enaida H.; Yuzawa M.; Yokomizo T.; Kim Y.B.; Sweetnam P.; Ishibashi T.; Hafezi-Moghadam A.
ROCK-isoform-specific polarization of macrophages associated with age-related macular degeneration
Cell Reports 10 (7): 1173-1186 (2015-02-24)



Blackburn J.; Kawasaki K.; Porntaveetus T.; Kawasaki M.; Otsuka-Tanaka Y.; Miake Y.; Ota M.S.; Watanabe M.; Hishinuma M.; Nomoto T.; Oommen S.; Ghafoor S.; Harada F.; Nozawa-Inoue K.; Maeda T.; Peterkova R.; Lesot H.; Inoue J.; Akiyama T.; Schmidt-Ullrich R.; Liu B.; Hu Y.; Page A.; Ramirez A.; Sharpe P.T.; Ohazama A.
Excess NF-{kappa}B induces ectopic odontogenesis in embryonic incisor epithelium
Journal of Dental Research 94 (1): 121-128 (2015-01)



2014

Yilmaz Z.B.; Kofahl B.; Beaudette P.; Baum K.; Ipenberg I.; Weih F.; Wolf J.; Dittmar G.; Scheidereit C.
Quantitative dissection and modeling of the NF-{kappa}B p100-p105 module reveals interdependent precursor proteolysis
Cell Reports 9 (5): 1756-1769 (2014-12-11)



Kreher S.; Bouhlel M.A.; Cauchy P.; Lamprecht B.; Li S.; Grau M.; Hummel F.; Koechert K.; Anagnostopoulos I.; Joehrens K.; Hummel M.; Hiscott J.; Wenzel S.S.; Lenz P.; Schneider M.; Kueppers R.; Scheidereit C.; Giefing M.; Siebert R.; Rajewsky K.; Lenz G.; Cockerill P.N.; Janz M.; Doerken B.; Bonifer C.; Mathas S.
Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma
Proceedings of the National Academy of Sciences of the United States of America 111 (42): E4513-E4522 (2014-10-21)



Kloepper J.E.; Ernst N.; Krieger K.; Bodo E.; Biro T.; Haslam I.S.; Schmidt-Ullrich R.; Paus R.
NF-{kappa}B activity is required for anagen maintenance in human hair follicles in vitro
Journal of Investigative Dermatology 134 (7): 2036-2038 (2014-02-11)



Hinz M.; Scheidereit C.
The I{kappa}B kinase complex in NF-{kappa}B regulation and beyond
EMBO Reports 15 (1): 46-61 (2014-01-01)



2013

Nogai H.; Wenzel S.S.; Hailfinger S.; Grau M.; Kaergel E.; Seitz V.; Wollert-Wulf B.; Pfeifer M.; Wolf A.; Frick M.; Dietze K.; Madle H.; Tzankov A.; Hummel M.; Doerken B.; Scheidereit C.; Janz M.; Lenz P.; Thome M.; Lenz G.
I{kappa}B-{zeta} controls the constitutive NF-{kappa}B target gene network and survival of ABC DLBCL
Blood 122 (13): 2242-2250 (2013-09-26)



Kusch A.; Hoff U.; Bubalo G.; Zhu Y.; Fechner M.; Schmidt-Ullrich R.; Marko L.; Mueller D.N.; Schmidt-Ott K.M.; Guergen D.; Blum M.; Schunck W.H.; Dragun D.
Novel signalling mechanisms and targets in renal ischaemia and reperfusion injury
Acta Physiologica 208 (1): 25-40 (2013-05)



Nakamura M.; Schneider M.R.; Schmidt-Ullrich R.; Paus R.
Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: an update
Journal of Dermatological Science 69 (1): 6-29 (2013-01)



2012

Lehmann S.M.; Krueger C.; Park B.; Derkow K.; Rosenberger K.; Baumgart J.; Trimbuch T.; Eom G.; Hinz M.; Kaul D.; Habbel P.; Kaelin R.; Franzoni E.; Rybak A.; Nguyen D.; Veh R.; Ninnemann O.; Peters O.; Nitsch R.; Heppner F.L.; Golenbock D.; Schott E.; Ploegh H.L.; Wulczyn F.G.; Lehnardt S.
An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration
Nature Neuroscience 15 (6): 827-835 (2012-06)



Blackburn J.; Ohazama A.; Kawasaki K.; Otsuka-Tanaka Y.; Liu B.; Honda K.; Rountree R.B.; Hu Y.; Kawasaki M.; Birchmeier W.; Schmidt-Ullrich R.; Kinoshita A.; Schutte B.C.; Hammond N.L.; Dixon M.J.; Sharpe P.T.
The role of Irf6 in tooth epithelial invagination
Developmental Biology 365 (1): 61-70 (2012-05-01)



Voutilainen M.; Lindfors P.H.; Lefebvre S.; Ahtiainen L.; Fliniaux I.; Rysti E.; Murtoniemi M.; Schneider P.; Schmidt-Ullrich R.; Mikkola M.L.
Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-kappaB
Proceedings of the National Academy of Sciences of the United States of America 109 (15): 5744-5749 (2012-04-10)



Hinz M.; Coel Arslan S.; Scheidereit C.
It takes two to tango: IkappaBs, the multifunctional partners of NF-kappaB
Immunological Reviews 246 (1): 59-76 (2012-03)



2011

Jing H.; Kase J.; Doerr J.R.; Milanovic M.; Lenze D.; Grau M.; Beuster G.; Ji S.; Reimann M.; Lenz P.; Hummel M.; Doerken B.; Lenz G.; Scheidereit C.; Schmitt C.A.; Lee S.
Opposing roles of NF-{kappa}B in anti-cancer treatment outcome unveiled by cross-species investigations
Genes & Development 25 (20): 2137-2146 (2011-10-15)



Coel Arslan S.; Scheidereit C.
The prevalence of TNF{alpha}-induced necrosis over apoptosis is determined by TAK1-RIP1 interplay
PLoS ONE 6 (10): e26069 (2011-10-10)



Haeaerae O.; Fujimori S.; Schmidt-Ullrich R.; Hartmann C.; Thesleff I.; Mikkola M.L.
Ectodysplasin and Wnt pathways are required for salivary gland branching morphogenesis
Development 138 (13): 2681-2691 (2011-07)



2010

Hinz M.; Stilmann M.; Coel Arslan S.; Khanna K.K.; Dittmar G.; Scheidereit C.
A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-kappaB activation
Molecular Cell 40 (1): 63-74 (2010-10-08)



Rauch A.; Seitz S.; Baschant U.; Schilling A.F.; Illing A.; Stride B.; Kirilov M.; Mandic V.; Takacz A.; Schmidt-Ullrich R.; Ostermay S.; Schinke T.; Spanbroek R.; Zaiss M.M.; Angel P.E.; Lerner U.H.; David J.P.; Reichardt H.M.; Amling M.; Schuetz G.; Tuckermann J.P.
Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor
Cell Metabolism 11 (6): 517-531 (2010-06-09)



2009

Rehm A.; Anagnostopoulos I.; Gerlach K.; Broemer M.; Scheidereit C.; Joehrens K.; Huebler M.; Hetzer R.; Stein H.; Lipp M.; Doerken B.; Hoepken U.E.
Identification of a chemokine receptor profile characteristic for mediastinal large B-cell lymphoma
International Journal of Cancer 125 (10): 2367-2374 (2009-11-15)



Stilmann M.; Hinz M.; Coel Arslan S.; Zimmer A.; Schreiber V.; Scheidereit C.
A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced I{kappa}B kinase activation
Molecular Cell 36 (3): 365-378 (2009-11-13)



Zhang Y.; Tomann P.; Andl T.; Gallant N.M.; Huelsken J.; Jerchow B.; Birchmeier W.; Paus R.; Piccolo S.; Mikkola M.L.; Morrisey E.E.; Overbeek P.A.; Scheidereit C.; Millar S.E.; Schmidt-Ullrich R.
Reciprocal requirements for EDA/EDAR/NF-{kappa}B and Wnt/{beta}-catenin signaling pathways in hair follicle induction
Developmental Cell 17 (1): 49-61 (2009-07-21)



Schneider M.R.; Schmidt-Ullrich R.; Paus R.
The hair follicle as a dynamic miniorgan
Current Biology 19 (3): R132-T142 (2009-02-10)



Roel G.; Gent Y.Y.; Peterson-Maduro J.; Verbeek F.J.; Destree O.
Lef1 plays a role in patterning the mesoderm and ectoderm in Xenopus tropicalis
International Journal of Developmental Biology 53 (1): 81-89 (2009)



2008

Lovas A.; Radke D.; Albrecht D.; Yilmaz Z.B.; Moeller U.; Habenicht A.J.; Weih F.
Differential RelA- and RelB-dependent gene transcription in LTbetaR-stimulated mouse embryonic fibroblasts
BMC Genomics 9: 606 (2008-12-16)



Zhang Y.; Andl T.; Yang S.H.; Teta M.; Liu F.; Seykora J.T.; Tobias J.W.; Piccolo S.; Schmidt-Ullrich R.; Nagy A.; Taketo M.M.; Dlugosz A.A.; Millar S.E.
Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate
Development 135 (12): 2161-2172 (2008-06)



Liu F.; Chu E.Y.; Watt B.; Zhang Y.; Gallant N.M.; Andl T.; Yang S.H.; Lu M.M.; Piccolo S.; Schmidt-Ullrich R.; Taketo M.M.; Morrisey E.E.; Atit R.; Dlugosz A.A.; Millar S.E.
Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis
Developmental Biology 313 (1): 210-224 (2008-01-01)



2007

Oeckinghaus A.; Wegener E.; Welteke V.; Ferch U.; Coel Arslan S.; Ruland J.; Scheidereit C.; Krappmann D.
Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation
EMBO Journal 26 (22): 4634-4645 (2007-11-14)



Hinz M.; Broemer M.; Coel Arslan S.; Otto A.; Mueller E.C.; Dettmer R.; Scheidereit C.
Signal-responsiveness of Ikappa B kinases is determined by Cdc37-assisted transient interaction with Hsp90
Journal of Biological Chemistry 282 (44): 32311-32319 (2007-11-02)



Weichert W.; Boehm M.; Gekeler V.; Bahra M.; Langrehr J.; Neuhaus P.; Denkert C.; Imre G.; Weller C.; Hofmann H.P.; Niesporek S.; Jacob J.; Dietel M.; Scheidereit C.; Kristiansen G.
High expression of RelA/p65 is associated with activation of nuclear factor-kappaB-dependent signaling in pancreatic cancer and marks a patient population with poor prognosis
British Journal of Cancer 97: 523-530 (2007-08-14)



Henke N.; Schmidt-Ullrich R.; Dechend R.; Park J.K.; Qadri F.; Wellner M.; Obst M.; Gross V.; Dietz R.; Luft F.C.; Scheidereit C.; Mueller D.N.
Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage
Circulation Research 101 (3): 268-276 (2007-08-03)



Hinz M.; Scheidereit C.
Striking back at the activator: how IkappaB kinase terminates antigen receptor responses
Science's STKE Signal Transduction Knowledge Environment 384: pe19 (2007-05-01)



2006

Visekruna A.; Joeris T.; Seidel D.; Kroesen A.; Loddenkemper C.; Zeitz M.; Kaufmann S.H.E.; Schmidt-Ullrich R.; Steinhoff U.
Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis
Journal of Clinical Investigation 116 (12): 3195-3203 (2006-12)



Scheidereit C.
IkappaB kinase complexes: gateways to NF-kappaB activation and transcription
Oncogene 25 (51): 6685-6705 (2006-10-30)



Wegener E.; Oeckinghaus A.; Papadopoulou N.; Lavitas L.; Schmidt-Supprian M.; Ferch U.; Mak T.W.; Ruland J.; Heissmeyer V.; Krappmann D.
Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation
Molecular Cell 23 (1): 13-23 (2006-07-07)



Schmidt-Ullrich R.; Tobin D.J.; Lenhard D.; Schneider P.; Paus R.; Scheidereit C.
NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth
Development 133 (6): 1045-1057 (2006-03-15)



Scheidereit C.; Krappmann D.
NF-{kappa}B pathway
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2 : 1286-1292 (2006)



2005

Unterstab G.; Ludwig S.; Anton A.; Planz O.; Dauber B.; Krappmann D.; Heins G.; Ehrhardt C.; Wolff T.
Viral targeting of the interferon-beta-inducing Traf family member-associated NF-kappaB activator (TANK)-binding kinase-1
Proceedings of the National Academy of Sciences of the United States of America 102 (38): 13640-13645 (2005-09-09)



Mathas S.; Joehrens K.; Joos S.; Lietz A.; Hummel F.; Janz M.; Jundt F.; Anagnostopoulos I.; Bommert K.; Lichter P.; Stein H.; Scheidereit C.; Doerken B.
Elevated NF-kappaB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large cell, and other peripheral T-cell lymphomas
Blood 106 (13): 4287-4293 (2005-08-25)



Schmidt-Ullrich R.; Paus R.
Molecular principles of hair follicle induction and morphogenesis
BioEssays 27 (3): 247-261 (2005-02-15)



Mehrhof F.B.; Schmidt-Ullrich R.; Dietz R.; Scheidereit C.
Regulation of vascular smooth muscle cell proliferation. Role of NF-kappaB revisited
Circulation Research 96 (9): 958-964 (2005-01-01)



Krappmann D.; Scheidereit C.
A pervasive role of ubiquitin conjugation in activation and termination of IkappaB kinase pathways
EMBO Reports 6 (4): 321-326 (2005-01-01)



Freund C.; Schmidt-Ullrich R.; Baurand A.; Dunger S.; Schneider W.; Loser P.; El-Jamali A.; Dietz R.; Scheidereit C.; Bergmann M.W.
Requirement of nuclear factor-kappaB in angiotensin II- and isoproterenol-induced cardiac hypertrophy in vivo
Circulation 111 (18): 2319-2325 (2005-01-01)



Salanova B.; Choi M.; Rolle S.; Wellner M.; Scheidereit C.; Luft F.C.; Kettritz R.
The effect of fever-like temperatures on neutrophil signaling
FASEB Journal 19 (7): 816-818 (2005-01-01)



2004

Broemer M.; Krappmann D.; Scheidereit C.
Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation
Oncogene 23 (31): 5378-5386 (2004-07-08)



Krappmann D.; Wegener E.; Sunami Y.; Esen M.; Thiel A.; Mordmueller B.; Scheidereit C.
The I{kappa}B kinase complex and NF-{kappa}B act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1
Molecular and Cellular Biology 24 (14): 6488-6500 (2004-07-01)



Scharschmidt E.; Wegener E.; Heissmeyer V.; Rao A.; Krappmann D.
Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappaB signaling
Molecular and Cellular Biology 24 (9): 3860-3873 (2004-05-01)



El Jamali A.; Freund C.; Rechner C.; Scheidereit C.; Dietz R.; Bergmann M.W.
Reoxygenation after severe hypoxia induces cardiomyocyte hypertrophy in vitro: activation of CREB downstream of GSK3beta
FASEB Journal 18 (10): 1096-1098 (2004-01-01)



Ohazama A.; Hu Y.L.; Schmidt-Ullrich R.; Cao Y.X.; Scheidereit C.; Karin M.; Sharpe P.T.
A dual role for lkkalpha in tooth development
Developmental Cell 6 (2): 219-227 (2004-01-01)



2003

Choi M.; Rolle S.; Wellner M.; Cardoso M.C.; Scheidereit C.; Luft F.C.; Kettritz R.
Inhibition of NF-{kappa} B by a TAT-NEMO-binding domain peptide accelerates constitutive apoptosis and abrogates LPS-delayed neutrophil apoptosis
Blood 102 (6): 2259-2267 (2003-09-15)



Mathas S.; Lietz A.; Janz M.; Hinz M.; Jundt F.; Scheidereit C.; Bommert K.; Doerken B.
Inhibition of NF-{kappa} B essentially contributes to arsenic-induced apoptosis
Blood 102 (3): 1028-1034 (2003-08-01)



Tegethoff S.; Behlke J.; Scheidereit C.
Tetrameric oligomerization of I kappa B kinase gamma (IKK gamma) is obligatory for IKK complex activity and NF-kappa B activation
Molecular and Cellular Biology 23 (6): 2029-2041 (2003-03)



Mordmueller B.; Krappmann D.; Esen M.; Wegener E.; Scheidereit C.
Lymphotoxin and lipopolysaccharide induce NF-{kappa}B-p52 generation by a co-translational mechanism
EMBO Reports 4 (1): 82-87 (2003-01-01)



Scheidereit C.
The pathogenetic significance of deregulated signal transduction pathways in Hodgkin's disease: the NF-kappaB-AP-1 network
Verhandlungen der Deutschen Gesellschaft fuer Pathologie 87: 79-89 (2003-01-01)



2002

Hinz M.; Lemke P.; Anagnostopoulos I.; Hacker C.; Krappmann D.; Mathas S.; Doerken B.; Zenke M.; Stein H.; Scheidereit C.
Nuclear factor {kappa}B-dependent gene expression profiling of Hodgkins disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity
Journal of Experimental Medicine 196 (5): 605-617 (2002-09-02)



Mathas S.; Hinz M.; Anagnostopoulos L.; Krappmann D.; Lietz A.; Jundt F.; Bommert K.; Mechta-Grigoriou F.; Stein H.; Doerken B.; Scheidereit C.
Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B
EMBO Journal 21 (15): 4104-4113 (2002-08-01)



Mori N.; Fujii M.; Hinz M.; Nakayama K.; Yamada Y.; Ikeda S.; Yamasaki Y.; Kashanchi F.; Tanaka Y.; Tomonaga M.; Yamamoto N.
Activation of cyclin D1 and D2 promoters by human T-cell leukemia virus type I tax protein is associated with IL-2-independent growth of T cells
International Journal of Cancer 99 (3): 378-385 (2002-05-20)



Jundt F.; Kley K.; Anagnostopoulos I.; Schulze-Proebsting K.; Greiner A.; Mathas S.; Scheidereit C.; Wirth T.; Stein H.; Doerken B.
Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease
Blood 99 (8): 3060-3062 (2002-04-15)



Hoepken U.E.; Foss H.D.; Meyer D.; Hinz M.; Leder K.; Stein H.; Lipp M.
Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs
Blood 99 (4): 1109-1116 (2002-01-01)



Hawkes N.A.; Otero G.; Winkler G.S.; Marshall N.; Dahmus M.E.; Krappmann D.; Scheidereit C.; Thomas C.L.; Schiavo G.; Erdjument-Bromage H.; Tempst P.; Svejstrup J.Q.
Purification and characterization of the human Elongator complex
Journal of Biological Chemistry 277 (4): 3047-3052 (2002-01-01)



2001

Kun J.F.; Mordmueller B.; Perkins D.J.; May J.; Mercereau-Puijalon O.; Alpers M.; Weinberg J.B.; Kremsner P.G.
Nitric oxide synthase 2Lambarene (G-954C), increased nitric oxide production, and protection against malaria
Journal of Infectious Diseases 184 (3): 330-336 (2001-08-01)



Holtmann H.; Enninga J.; Kalble S.; Thiefes A.; Dorrie A.; Broemer M.; Winzen R.; Wilhelm A.; Ninomiya-Tsuji J.; Matsumoto K.; Resch K.; Kracht M.
The MAPK kinase kinase TAK1 plays a central role in coupling the interleukin-1 receptor to both transcriptional and RNA-targeted mechanisms of gene regulation
Journal of Biological Chemistry 276: 3508-3516 (2001-02-02)



Schmidt-Ullrich R.; Aebischer T.; Huelsken J.; Birchmeier W.; Klemm U.; Scheidereit C.
Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices
Development 128 (19): 3843-3853 (2001-01-01)



Mehrhof F.B.; Mueller F.U.; Bergmann M.W.; Li P.F.; Wang Y.B.; Schmitz W.; Dietz R.; von Harsdorf R.
In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein
Circulation 104: 2088-2094 (2001-01-01)



Hinz M.; Loeser P.; Mathas S.; Krappmann D.; Doerken B.; Scheidereit C.
Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells
Blood 97 (9): 2798-2807 (2001-01-01)



Mueller D.N.; Heissmeyer V.; Dechend R.; Hampich F.; Park J.K.; Fiebeler A.; Shagdarsuren E.; Theuer J.; Elger M.; Pilz B.; Breu V.; Schroer K.; Ganten D.; Dietz R.; Haller H.; Scheidereit C.; Luft F.C.
Aspirin inhibits NF-kappa B and protects from angiotensin II-induced organ damage
FASEB Journal 15: 1822-1824 (2001-01-01)



Wuchter C.; Krappmann D.; Cai Z.; Ruppert V.; Scheidereit C.; Doerken B.; Ludwig W.D.; Karawajew L.
In vitro susceptibility to TRAIL-induced apoptosis of acute leukemia cells in the context of TRAIL receptor gene expression and constitutive NF-kappaB activity
Leukemia 15 (6): 921-928 (2001-01-01)



Krappmann D.; Patke A.; Heissmeyer V.; Scheidereit C.
B-cell receptor- and phorbol ester-induced NF-kappa B and c-Jun N-terminal kinase activation in B cells requires novel protein kinase C's
Molecular and Cellular Biology 21: 6640-6650 (2001-01-01)



Slaugenhaupt S.A.; Blumenfeld A.; Gill S.P.; Leyne M.; Mull J.; Cuajungco M.P.; Liebert C.B.; Chadwick B.; Idelson M.; Reznik L.; Robbins C.M.; Makalowska I.; Brownstein M.J.; Krappmann D.; Scheidereit C.; Maayan C.; Axelrod F.B.; Gusella J.F.
Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia
American Journal of Human Genetics 68: 598-605 (2001-01-01)



Heissmeyer V.; Krappmann D.; Hatada E.N.; Scheidereit C.
Shared pathways of IkappaB kinase-induced SCF betaTrCP-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and I kappa B alpha
Molecular and Cellular Biology 21 (4): 1024-1035 (2001-01-01)



2000

Jueliger S.; Luckner D.; Mordmueller B.; May J.; Weierich A.; Lell B.; Luty A.; Kremsner P.G.; Kun J.F.
Promoter variants of the human mannose-binding lectin gene show different binding
Biochemical and Biophysical Research Communications 275: 617-622 (2000-08-28)



Feuillard J.; Memet S.; Goudeau B.; Lilienbaum A.; Schmidt-Ullrich R.; Raphael M.; Israel A.
In vivo identification of lymphocyte subsets exhibiting transcriptionally active NF-kappaB/Rel complexes
International Immunology 12 (5): 613-621 (2000-05)



Hehner S.P.; Hofmann T.G.; Ushmorov A.; Dienz O.; Leung I.W.L.; Lassam N.; Scheidereit C.; Droege W.; Schmitz M.L.
Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex
Molecular and Cellular Biology 20: 2556-2568 (2000-04-01)



Lange K.; Kleuser B.; Gysler A.; Bader M.; Maia C.; Scheidereit C.; Korting H.C.; Schaefer-Korting M.
Cutaneous inflammation and proliferation in vitro: Differential effects and mode of action of topical glucocorticoids
Skin Pharmacology and Applied Skin Physiology 13 (2): 93-103 (2000-03-01)



Kordes U.; Krappmann D.; Heissmeyer V.; Ludwig W.D.; Scheidereit C.
Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells
Leukemia 14 (3): 399-402 (2000-03)



Hatada E.N.; Krappmann D.; Scheidereit C.
NF-kappaB and the innate immune response
Current Opinion in Immunology 12: 52-58 (2000-02-01)



Mathas S.; Rickers A.; Bommert K.; Doerken B.; Mapara M.Y.
Anti-CD20-and B-cell receptor-mediated apoptosis: Evidence for shared intracellular signaling pathways
Cancer Research 60 (24): 7170-7176 (2000-01-01)



Krappmann D.; Hatada E.N.; Tegethoff S.; Li J.; Klippel A.; Giesel K.; Baeuerle A.; Scheidereit C.
The IkappaB kinase (IKK) complex is tripartiteand contains IKKgamma but not IKAP as a regular component
Journal of Biological Chemistry 275: 29779-29787 (2000-01-01)



Hatada E.N.; Chen-Kiang S.; Scheidereit C.
Interaction and functional interference of C/EBPbeta with octamer factors in immunoglobulin gene transcription
European Journal of Immunology 30 (1): 174-184 (2000-01-01)



1999

Emmerich F.; Meiser M.; Hummel M.; Demel G.; Foss H.D.; Jundt F.; Mathas S.; Krappmann D.; Scheidereit C.; Stein H.; Doerken B.
Overexpression of IkappaBalpha without inhibition of NF-kappaB activity and mutations in the IkappaBalpha gene in Reed-Sternberg cells
Blood 94: 3129-3134 (1999-11-01)



Dechend R.; Maass M.; Gieffers J.; Dietz R.; Scheidereit C.; Leutz A.; Gulba D.C.
Chlamydia pneumoniae infection of vascular smooth muscle and endothelial cells activates NF-kappaB and induces tissue factor and PAI-1 expression - A potential link to accelerated arteriosclerosis
Circulation 100: 1369-1373 (1999-09-28)



Heissmeyer V.; Krappmann D.; Wulczyn F.G.; Scheidereit C.
NF-kappaB p105 is a target of I kappaB kinases and controls signal induction of Bcl-3-p50 complexes
EMBO Journal 18: 4766-4778 (1999-09-01)



von Harsdorf R.; Hauck L.; Mehrhof F.; Wegenka U.; Cardoso M.C.; Dietz R.
E2F-1 overexpression in cardiomyocytes induces downregulation of p21CIP1 and p27KIP1 and release of active cyclin-dependent kinases in the presence of insulin-like growth factor I
Circulation Research 85: 128-136 (1999-07-23)



Dechend R.; Hirano F.; Lehmann K.; Heissmeyer V.; Ansieau S.; Wulczyn F.G.; Scheidereit C.; Leutz A.
The Bcl-3 oncoprotein acts as a bridging factor between NF-kappa B/Rel and nuclear co-regulators
Oncogene 18: 3316-3323 (1999-06-03)



Hinz M.; Krappmann D.; Eichten A.; Heder A.; Scheidereit C.; Strauss M.
NF-kappaB function in growth control: Regulation of cyclin D1 expression and G(0)G(1)-to-S-Phase transition
Molecular and Cellular Biology 19: 2690-2698 (1999-04-01)



Krappmann D.; Emmerich F.; Kordes U.; Scharschmidt E.; Doerken B.; Scheidereit C.
Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells
Oncogene 18: 943-953 (1999-01-28)



1998

Scheidereit C.
Signal transduction. Docking IkappaB kinases
Nature 395: 225-226 (1998-09-17)



Mordmueller B.; Turrini F.; Long H.; Kremsner P.G.; Arese P.
Neutrophils and monocytes from subjects with the Mediterranean G6PD variant: effect of Plasmodium falciparum hemozoin on G6PD activity, oxidative burst and cytokine production
European Cytokine Network 9: 239-245 (1998-09-01)



Hirano F.; Chung M.R.; Tanaka H.; Maruyama N.; Makino I.; Moore D.D.; Scheidereit C.
Alternative splicing variants of IkappaBbeta establish differential NF-kappaB signal responsiveness in human cells
Molecular and Cellular Biology 18 (5): 2596-2607 (1998-05)



Wulczyn F.G.; Krappmann D.; Scheidereit C.
Signal-dependent degradation of IkappaBalpha is mediated by an inducible destruction box that can be transferred to NF-kappaB, bcl-3 or p53
Nucleic Acids Research 26 (7): 1724-1730 (1998-04-01)



Mordmueller B.; Kremsner P.G.
Hyperparasitemia and blood exchange transfusion for treatment of children with falciparum malaria
Clinical Infectious Diseases 26: 850-852 (1998-04-01)



Hirano F.; Tanaka H.; Miura T.; Hirano Y.; Okamoto K.; Makino Y.; Makino I.
Inhibition of NF-kappaB-dependent transcription of human immunodeficiency virus 1 promoter by a phosphodiester compound of vitamin C and vitamin E, EPC-K1
Immunopharmacology 39: 31-38 (1998-03-01)



Hirano F.; Tanaka H.; Hirano Y.; Hiramoto M.; Handa H.; Makino I.; Scheidereit C.
Functional interference of Sp1 and NF-kappaB through the same DNA binding site
Molecular and Cellular Biology 18 (3): 1266-1274 (1998-03)



Kun J.F.; Mordmueller B.; Lell B.; Lehman L.G.; Luckner D.; Kremsner P.G.
Polymorphism in promoter region of inducible nitric oxide synthase gene and protection against malaria
Lancet 351 (9098): 265-266 (1998-01-24)



1997

Bargou R.C.; Emmerich F.; Krappmann D.; Bommert K.; Mapara M.Y.; Arnold W.; Royer H.D.; Grinstein E.; Greiner A.; Scheidereit C.; Doerken B.
Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells
Journal of Clinical Investigation 100 (12): 2961-2969 (1997-12-15)



Pelletier M.R.; Hatada E.N.; Scholz G.; Scheidereit C.
Efficient transcription of an immunoglobulin kappa promoter requires specific sequence elements overlapping with and downstream of the transcriptional start site
Nucleic Acids Research 25 (20): 3995-4003 (1997-10-15)



Mordmueller B.G.; Metzger W.G.; Juillard P.; Brinkman B.M.; Verweij C.L.; Grau G.E.; Kremsner P.G.
Tumor necrosis factor in Plasmodium falciparum malaria: high plasma level is associated with fever, but high production capacity is associated with rapid fever clearance
European Cytokine Network 8: 29-35 (1997-03-01)



Krappmann D.; Scheidereit C.
Regulation of NF-kappa B activity by I kappa B alpha and I kappa B beta stability
Immunobiology 198: 3-13 (1997-01-01)



Ruppitsch W.; Meisslitzer C.; Weirichschwaiger H.; Klocker H.; Scheidereit C.; Schweiger M.; Hirschkauffmann M.
The role of oxygen metabolism for the pathological phenotype of fanconi anemia
Human Genetics 99: 710-719 (1997-01-01)



1996

Krappmann D.; Wulczyn F.G.; Scheidereit C.
Different mechanisms control signal-induced degradation and basal turnover of the NF-kappab inhibitor ikappabalpha in vivo
EMBO Journal 15 (23): 6716-6726 (1996-12-02)



Schmidt-Ullrich R.; Memet S.; Lilienbaum A.; Feuillard J.; Raphael M.; Israel A.
NF-kappaB activity in transgenic mice: developmental regulation and tissue specificity
Development 122 (7): 2117-2128 (1996-07)



Scheidereit C.
Transcription factors: important tools and targets for molecular medicine
Journal of Molecular Medicine 74: 707-709 (1996-01-01)



Bargou R.C.; Leng C.; Krappmann D.; Emmerich F.; Mapara M.Y.; Bommert K.; Royer H.D.; Scheidereit C.; Doerken B.
High level nuclear NF-kB and Oct-2 is a common feature of cultured Hodgkin/Sternberg cells
Blood 87 (10): 4340-4347 (1996-01-01)



Wulczyn F.G.; Krappmann D.; Scheidereit C.
The NF-kappaB/Rel and IkappaB gene families: mediators of immune response and inflammation
Journal of Molecular Medicine 74: 749-769 (1996-01-01)



1994

Schafer U.; Rausch O.; Bouwmeester T.; Pieler T.
Sequence-specific recognition of a repetitive DNA element by a C2H2 zinc-finger protein in Xenopus
European Journal of Biochemistry 226: 567-576 (1994-12-01)



Naumann M.; Scheidereit C.
Activation of NF-kappaB in vivo is regulated by multiple phosphorylations
EMBO Journal 13 (19): 4597-4607 (1994-10-03)



Franke S.; Scholz G.; Scheidereit C.
Identification of novel ubiquitous and cell type-specific factors that specifically recognize immunoglobulin heavy and light chain promoters
Journal of Biological Chemistry 269 (31): 20075-20082 (1994-08-05)



Bouwmeester T.; van Wijk I.; Wedlich D.; Pieler T.
Functional aspects of B-Myb in early Xenopus development
Oncogene 9 (4): 1029-1038 (1994-04)



Klocke B.; Koester M.; Hille S.; Bouwmeester T.; Boehm S.; Pieler T.; Knoechel W.
The FAR domain defines a new Xenopus laevis zinc finger protein subfamily with specific RNA homopolymer binding activity
Biochimica et Biophysica Acta 1217: 81-89 (1994-01-01)



1993

Naumann M.; Nieters A.; Hatada E.N.; Scheidereit C.
NF-kappaB precursor p100 inhibits nuclear translocation and DNA binding of NF-kappaB/rel-factors
Oncogene 8 (8): 2275-2281 (1993-08-01)



Hatada E.N.; Naumann M.; Scheidereit C.
Common structural constituents confer IkappaB activity to NF-kappaB p105 and IkappaB/MAD-3
EMBO Journal 12 (7): 2781-2788 (1993-07)



Naumann M.; Wulczyn F.G.; Scheidereit C.
The NF-kappaB precursor p105 and the proto-oncogene product Bcl- 3 are I kappa B molecules and control nuclear translocation of NF-kappa B
EMBO Journal 12 (1): 213-222 (1993-01)



1992

Kretzschmar M.; Meisterernst M.; Scheidereit C.; Li G.; Roeder R.G.
Transcriptional regulation of the HIV-1 promoter by NF-kappa B in vitro
Genes & Development 6 (5): 761-774 (1992-05)



Wulczyn F.G.; Naumann M.; Scheidereit C.
Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappaB
Nature 358 (6387): 597-599 (1992-01-01)



Hatada E.N.; Nieters A.; Wulczyn F.G.; Naumann M.; Meyer R.; Nucifora G.; McKeithan T.W.; Scheidereit C.
The ankyrin repeat domains of the NF-kappa B precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF-kappaB DNA binding
Proceedings of the National Academy of Sciences of the United States of America 89 (6): 2489-2493 (1992-01-01)