Recent publications


Zadora J.; Singh M.; Herse F.; Przybyl L.; Haase N.; Golic M.; Yung H.W.; Huppertz B.; Cartwright J.E.; Whitley G.S.; Johnsen G.M.; Levi G.; Isbruch A.; Schulz H.; Luft F.C.; Mueller D.N.; Staff A.C.; Hurst L.D.; Dechend R.; Izsvak Z.
Disturbed placental imprinting in preeclampsia leads to altered expression of DLX5, a human-specific early trophoblast marker
Circulation 136 (19): 1824-1839 (2017-11-07)

Kebriaei P.; Izsvak Z.; Narayanavari S.A.; Singh H.; Ivics Z.
Gene therapy with the Sleeping Beauty transposon system
Trends in Genetics 33 (11): 852-870 (2017-11)

Hodge R.; Narayanavari S.; Izsvak Z.; Ivics Z.
Wide awake and ready to move: 20 years of non-viral therapeutic genome engineering with the Sleeping Beauty transposon system
Human Gene Therapy 28 (10): 842-855 (2017-10-01)

Siska E.K.; Weisman I.; Romano J.; Ivics Z.; Izsvak Z.; Barkai U.; Petrakis S.; Koliakos G.
Generation of an immortalized mesenchymal stem cell line producing a secreted biosensor protein for glucose monitoring
PLoS ONE 12 (9): e0185498 (2017-09-26)

Hudecek M.; Izsvak Z.; Johnen S.; Renner M.; Thumann G.; Ivics Z.
Going non-viral: the Sleeping Beauty transposon system breaks on through to the clinical side
Critical Reviews in Biochemistry and Molecular Biology 52 (4): 355-380 (2017-08)

Roemer C.; Singh M.; Hurst L.D.; Izsvak Z.
How to tame an endogenous retrovirus: HERVH and the evolution of human pluripotency
Current Opinion in Virology 25: 49-58 (2017-08)

Prokesch A.; Blaschitz A.; Bauer T.; Moser G.; Hiden U.; Zadora J.; Dechend R.; Herse F.; Gauster M.
Placental DAPK1 and autophagy marker LC3B-II are dysregulated by TNF-{alpha} in a gestational age-dependent manner
Histochemistry and Cell Biology 147 (6): 695-705 (2017-06)

Liska F.; Landa V.; Zidek V.; Mlejnek P.; Silhavy J.; Simakova M.; Strnad H.; Trnovska J.; Skop V.; Kazdova L.; Starker C.G.; Voytas D.F.; Izsvak Z.; Mancini M.; Seda O.; Kren V.; Pravenec M.
Downregulation of Plzf gene ameliorates metabolic and cardiac traits in the spontaneously hypertensive rat
Hypertension 69 (9): 1084-1091 (2017-06)

Lorenz C.; Lesimple P.; Bukowiecki R.; Zink A.; Inak G.; Mlody B.; Singh M.; Semtner M.; Mah N.; Aure K.; Leong M.; Zabiegalov O.; Lyras E.M.; Pfiffer V.; Fauler B.; Eichhorst J.; Wiesner B.; Huebner N.; Priller J.; Mielke T.; Meierhofer D.; Izsvak Z.; Meier J.C.; Bouillaud F.; Adjaye J.; Schuelke M.; Wanker E.E.; Lombes A.; Prigione A.
Human iPSC-derived neural progenitors are an effective drug discovery model for neurological mtDNA disorders
Cell Stem Cell 20 (5): 659-674.e9 (2017-05-04)

Verhenne S.; Vandeputte N.; Pareyn I.; Izsvak Z.; Rottensteiner H.; Deckmyn H.; De Meyer S.F.; Vanhoorelbeke K.
Long-term prevention of congenital thrombotic thrombocytopenic purpura in ADAMTS13 knockout mice by sleeping beauty transposon-mediated gene therapy
Arteriosclerosis, Thrombosis, and Vascular Biology 37 (5): 836-844 (2017-05)

Zhou M.B.; Hu H.; Miskey C.; Lazarow K.; Ivics Z.; Kunze R.; Yang G.; Izsvak Z.; Tang D.Q.
Transposition of the bamboo Mariner-like element Ppmar1 in yeast
Molecular Phylogenetics and Evolution 109: 367-374 (2017-04)

Kufeld M.; Escobar H.; Marg A.; Pasemann D.; Budach V.; Spuler S.
Localized irradiation of mouse legs using an image-guided robotic linear accelerator
Annals of Translational Medicine 5 (7): 156 (2017-04)

Narayanavari S.A.; Izsvak Z.
Sleeping Beauty transposon vectors for therapeutic applications: advances and challenges
Cell and Gene Therapy Insights 3 (2): 131-158 (2017-03-30)

Thumann G.; Harmening N.; Prat-Souteyrand C.; Marie C.; Pastor M.; Sebe A.; Miskey C.; Hurst L.; Diarra S.; Kropp M.; Walter P.; Scherman D.; Ivics Z.; Izsvak Z.; Johnen S.
Engineering of PEDF-expressing primary pigment epithelial cells by the SB transposon system delivered by pFAR4 plasmids
Molecular Therapy - Nucleic Acids 6: 302-314 (2017-03-17)

Wang Y.; Pryputniewicz-Dobrinska D.; Nagy E.E.; Kaufman C.D.; Singh M.; Yant S.; Wang J.; Dalda A.; Kay M.A.; Ivics Z.; Izsvak Z.
Regulated complex assembly safeguards the fidelity of Sleeping Beauty transposition
Nucleic Acids Research 45 (1): 311-326 (2017-01-09)

Narayanavari S.A.; Chilkunda S.S.; Ivics Z.; Izsvak Z.
Sleeping Beauty transposition: from biology to applications
Critical Reviews in Biochemistry and Molecular Biology 52 (1): 18-44 (2017-01)


Richter M.; Saydaminova K.; Yumul R.; Krishnan R.; Liu J.; Nagy E.E.; Singh M.; Izsvak Z.; Cattaneo R.; Uckert W.; Palmer D.; Ng P.; Haworth K.G.; Kiem H.P.; Ehrhardt A.; Papayannopoulou T.; Lieber A.
In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors
Blood 128 (18): 2206-2217 (2016-11-03)

Liska F.; Peterkova R.; Peterka M.; Landa V.; Zidek V.; Mlejnek P.; Silhavy J.; Simakova M.; Kren V.; Starker C.G.; Voytas D.F.; Izsvak Z.; Pravenec M.
Targeting of the Plzf gene in the rat by transcription activator-like effector nuclease results in caudal regression syndrome in spontaneously hypertensive rats
PLoS ONE 11 (10): e0164206 (2016-10-11)

Abrusan G.; Yant S.R.; Szilagyi A.; Marsh J.A.; Mates L.; Izsvak Z.; Barabas O.; Ivics Z.
Structural determinants of sleeping beauty transposase activity
Molecular Therapy 24 (8): 1369-1377 (2016-08)

Voigt F.; Wiedemann L.; Zuliani C.; Querques I.; Sebe A.; Mates L.; Izsvak Z.; Ivics Z.; Barabas O.
Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering
Nature Communications 7: 11126 (2016-03-30)

Grabundzija I.; Messing S.A.; Thomas J.; Cosby R.L.; Bilic I.; Miskey C.; Gogol-Doering A.; Kapitonov V.; Diem T.; Dalda A.; Jurka J.; Pritham E.J.; Dyda F.; Izsvak Z.; Ivics Z.
A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes
Nature Communications 7: 10716 (2016-03-02)

Fatima A.; Ivanyuk D.; Herms S.; Heilmann-Heimbach S.; O'Shea O.; Chapman C.; Izsvak Z.; Farr M.; Hescheler J.; Saric T.
Generation of human induced pluripotent stem cell line from a patient with a long QT syndrome type 2
Stem Cell Research 16 (2): 304-307 (2016-03)

Gogol-Doering A.; Ammar I.; Gupta S.; Bunse M.; Miskey C.; Chen W.; Uckert W.; Schulz T.F.; Izsvak Z.; Ivics Z.
Genome-wide profiling reveals remarkable parallels between insertion site selection properties of the MLV retrovirus and the piggyBac transposon in primary human CD4+ T cells
Molecular Therapy 24 (3): 592-606 (2016-03)

Turunen T.A.K.; Kurkipuro J.; Heikura T.; Vuorio T.; Hytoenen E.; Izsvak Z.; Ylae-Herttuala S.
Sleeping Beauty transposon vectors in liver directed gene delivery of LDLR and VLDLR for gene therapy of familial hypercholesterolemia
Molecular Therapy 24 (3): 620-635 (2016-03)

Garrels W.; Mukherjee A.; Holler S.; Cleve N.; Talluri T.R.; Barg-Kues B.; Diederich M.; Koehler P.; Petersen B.; Lucas-Hahn A.; Niemann H.; Izsvak Z.; Ivics Z.; Kues W.A.
Identification and re-addressing of a transcriptionally permissive locus in the porcine genome
Transgenic Research 25 (1): 63-70 (2016-02)

Wang J.; Singh M.; Sun C.; Besser D.; Prigione A.; Ivics Z.; Hurst L.D.; Izsvak Z.
Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression
Nature Protocols 11 (2): 327-346 (2016-02)

Escobar H.; Schoewel V.; Spuler S.; Marg A.; Izsvak Z.
Full-length dysferlin transfer by the hyperactive Sleeping Beauty transposase restores dysferlin-deficient muscle
Molecular Therapy - Nucleic Acids 5: e277 (2016-01-19)

Klawitter S.; Fuchs N.V.; Upton K.R.; Munoz-Lopez M.; Shukla R.; Wang J.; Garcia-Canadas M.; Lopez-Ruiz C.; Gerhardt D.J.; Sebe A.; Grabundzija I.; Merkert S.; Gerdes P.; Pulgarin J.A.; Bock A.; Held U.; Witthuhn A.; Haase A.; Sarkadi B.; Loewer J.; Wolvetang E.J.; Martin U.; Ivics Z.; Izsvak Z.; Garcia-Perez J.L.; Faulkner G.J.; Schumann G.G.
Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells
Nature Communications 7: 10286 (2016-01-08)

Izsvak Z.; Wang J.; Singh M.; Mager D.L.; Hurst L.D.
Pluripotency and the endogenous retrovirus HERVH: Conflict or serendipity?
BioEssays 38 (1): 109-117 (2016-01)


Grandi F.C.; Rosser J.M.; Newkirk S.J.; Yin J.; Jiang X.; Xing Z.; Whitmore L.; Bashir S.; Ivics Z.; Izsvak Z.; Ye P.; Yu Y.E.; An W.
Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites
Genome Research 25 (8): 1135-1146 (2015-08)

Thumann G.; Perdikomati-Dahmen M.; Izsvak Z.; Ivics Z.; Garcia Layana A.; Ronchetti M.; Petrovski G.; Scherman D.; Aranda P.; Pouillot S.; Binder S.; Johnen S.; Van den Berg J.
Transposon-based, targeted ex vivo gene therapy to treat age-related macular degeneration (TargetAMD)
Human Gene Therapy Clinical Development 26 (2): 97-100 (2015-06-18)

Ivics Z.; Izsvak Z.
Sleeping Beauty transposition
Microbiology Spectrum 3 (2): (2015-04)

Johnen S.; Djalali-Talab Y.; Kazanskaya O.; Moeller T.; Harmening N.; Kropp M.; Izsvak Z.; Walter P.; Thumann G.
Antiangiogenic and neurogenic activities of Sleeping Beauty-mediated PEDF-transfected RPE cells in vitro and in vivo
BioMed Research International 2015: 863845 (2015)


Wang J.; Xie G.; Singh M.; Ghanbarian A.T.; Rasko T.; Szvetnik A.; Cai H.; Besser D.; Prigione A.; Fuchs N.V.; Schumann G.G.; Chen W.; Lorincz M.C.; Ivics Z.; Hurst L.D.; Izsvak Z.
Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells
Nature 516 (7531): 405-409 (2014-12-18)

Turchiano G.; Latella M.C.; Gogol-Doering A.; Cattoglio C.; Mavilio F.; Izsvak Z.; Ivics Z.; Recchia A.
Genomic analysis of Sleeping Beauty transposon integration in human somatic cells
PLoS ONE 9 (11): e112712 (2014-11-12)

Marg A.; Escobar H.; Gloy S.; Kufeld M.; Zacher J.; Spuler A.; Birchmeier C.; Izsvak Z.; Spuler S.
Human satellite cells have regenerative capacity and are genetically manipulable
Journal of Clinical Investigation 124 (10): 4257-4265 (2014-10-01)

Carbone L.; Harris R.A.; Gnerre S.; Veeramah K.R.; Lorente-Galdos B.; Huddleston J.; Meyer T.J.; Herrero J.; Roos C.; Aken B.; Anaclerio F.; Archidiacono N.; Baker C.; Barrell D.; Batzer M.A.; Beal K.; Blancher A.; Bohrson C.L.; Brameier M.; Campbell M.S.; Capozzi O.; Casola C.; Chiatante G.; Cree A.; Damert A.; de Jong P.J.; Dumas L.; Fernandez-Callejo M.; Flicek P.; Fuchs N.V.; Gut I.; Gut M.; Hahn M.W.; Hernandez-Rodriguez J.; Hillier L.W.; Hubley R.; Ianc B.; Izsvak Z.; Jablonski N.G.; Johnstone L.M.; Karimpour-Fard A.; Konkel M.K.; Kostka D.; Lazar N.H.; Lee S.L.; Lewis L.R.; Liu Y.; Locke D.P.; Mallick S.; Mendez F.L.; Muffato M.; Nazareth L.V.; Nevonen K.A.; O'Bleness M.; Ochis C.; Odom D.T.; Pollard K.S.; Quilez J.; Reich D.; Rocchi M.; Schumann G.G.; Searle S.; Sikela J.M.; Skollar G.; Smit A.; Sonmez K.; ten Hallers B.; Terhune E.; Thomas G.W.C.; Ullmer B.; Ventura M.; Walker J.A.; Wall J.D.; Walter L.; Ward M.C.; Wheelan S.J.; Whelan C.W.; White S.; Wilhelm L.J.; Woerner A.E.; Yandell M.; Zhu B.; Hammer M.F.; Marques-Bonet T.; Eichler E.E.; Fulton L.; Fronick C.; Muzny D.M.; Warren W.C.; Worley K.C.; Rogers J.; Wilson R.K.; Gibbs R.A.
Gibbon genome and the fast karyotype evolution of small apes
Nature 513 (7517): 195-201 (2014-09-11)

Molyneux S.D.; Waterhouse P.D.; Shelton D.; Shao Y.W.; Watling C.M.; Tang Q.L.; Harris I.S.; Dickson B.C.; Tharmapalan P.; Sandve G.K.; Zhang X.; Bailey S.D.; Berman H.; Wunder J.S.; Izsvak Z.; Lupien M.; Mak T.W.; Khokha R.
Human somatic cell mutagenesis creates genetically tractable sarcomas
Nature Genetics 46 (9): 964-972 (2014-09)

Kolacsek O.; Erdei Z.; Apati A.; Sandor S.; Izsvak Z.; Ivics Z.; Sarkadi B.; Orban T.I.
Excision efficiency is not strongly coupled to transgenic rate: cell type dependent transposition efficiency of Sleeping Beauty and piggyBac DNA transposons
Human Gene Therapy Methods 25 (4): 241-252 (2014-08)

Ivics Z.; Mates L.; Yau T.Y.; Landa V.; Zidek V.; Bashir S.; Hoffmann O.I.; Hiripi L.; Garrels W.; Kues W.A.; Boesze Z.; Geurts A.; Pravenec M.; Ruelicke T.; Izsvak Z.
Germline transgenesis in rodents by pronuclear microinjection of Sleeping Beauty transposons
Nature Protocols 9 (4): 773-793 (2014-04)

Ivics Z.; Hiripi L.; Hoffmann O.I.; Mates L.; Yau T.Y.; Bashir S.; Zidek V.; Landa V.; Geurts A.; Pravenec M.; Ruelicke T.; Boesze Z.; Izsvak Z.
Germline transgenesis in rabbits by pronuclear microinjection of Sleeping Beauty transposons
Nature Protocols 9 (4): 794-809 (2014-04)

Ivics Z.; Garrels W.; Mates L.; Yau T.Y.; Bashir S.; Zidek V.; Landa V.; Geurts A.; Pravenec M.; Ruelicke T.; Kues W.A.; Izsvak Z.
Germline transgenesis in pigs by cytoplasmic microinjection of Sleeping Beauty transposons
Nature Protocols 9 (4): 810-827 (2014-04)

Wang Y.; Wang J.; Devaraj A.; Singh M.; Jimenez Orgaz A.; Chen J.X.; Selbach M.; Ivics Z.; Izsvak Z.
Suicidal autointegration of Sleeping Beauty and piggyBac transposons in eukaryotic cells
PLoS Genetics 10 (3): e1004103 (2014-03-13)


Fuchs N.V.; Loewer S.; Daley G.Q.; Izsvak Z.; Loewer J.; Loewer R.
Human endogenous retrovirus K (HML-2) RNA and protein expression is a marker for human embryonic and induced pluripotent stem cells
Retrovirology 10 (1): 115 (2013-10-24)

Zhang W.; Solanki M.; Muether N.; Ebel M.; Wang J.; Sun C.; Izsvak Z.; Ehrhardt A.
Hybrid adeno-associated viral vectors utilizing transposase-mediated somatic integration for stable transgene expression in human cells
PLoS ONE 8 (10): e76771 (2013-10-08)

Zhang W.; Muck-Hausl M.; Wang J.; Sun C.; Gebbing M.; Miskey C.; Ivics Z.; Izsvak Z.; Ehrhardt A.
Integration profile and safety of an adenovirus hybrid-vector utilizing hyperactive Sleeping Beauty transposase for somatic integration
PLoS ONE 8 (10): e75344 (2013-10-04)

Molina-Estevez F.J.; Lozano M.L.; Navarro S.; Torres Y.; Grabundzija I.; Ivics Z.; Samper E.; Bueren J.A.; Guenechea G.
Impaired cell reprogramming in non-homologous end joining deficient cells
Stem Cells 31 (8): 1726-1730 (2013-08)

Jursch T.; Miskey C.; Izsvak Z.; Ivics Z.
Regulation of DNA transposition by CpG methylation and chromatin structure in human cells
Mobile DNA 4 (1): 15 (2013-05-15)

Xie Y.; Mates L.; Ivics Z.; Izsvak Z.; Martin S.L.; An W.
Cell division promotes efficient retrotransposition in a stable L1 reporter cell line
Mobile DNA 4 (1): 1-10 (2013-03-06)

Katter K.; Geurts A.M.; Hoffmann O.; Mates L.; Landa V.; Hiripi L.; Moreno C.; Lazar J.; Bashir S.; Zidek V.; Popova E.; Jerchow B.; Becker K.; Devaraj A.; Walter I.; Grzybowksi M.; Corbett M.; Filho A.R.; Hodges M.R.; Bader M.; Ivics Z.; Jacob H.J.; Pravenec M.; Bosze Z.; Ruelicke T.; Izsvak Z.
Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits
FASEB Journal 27 (3): 930-941 (2013-03)

Grabundzija I.; Wang J.; Sebe A.; Erdei Z.; Kajdi R.; Devaraj A.; Steinemann D.; Szuhai K.; Stein U.; Cantz T.; Schambach A.; Baum C.; Izsvak Z.; Sarkadi B.; Ivics Z.
Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells
Nucleic Acids Research 41 (3): 1829-1847 (2013-02-01)

Kues W.A.; Herrmann D.; Barg-Kues B.; Meena Haridoss S.; Nowak-Imialek M.; Buchholz T.; Streeck M.; Grebe A.; Grabundzija I.; Merkert S.; Martin U.; Hall V.J.; Rasmussen M.A.; Ivics Z.; Maddox-Hyttel P.; Niemann H.
Derivation and characterization of Sleeping Beauty transposon-mediated porcine induced pluripotent stem cells
Stem Cells and Development 22 (1): 124-135 (2013-01-01)

Hozumi A.; Mita K.; Miskey C.; Mates L.; Izsvak Z.; Ivics Z.; Satake H.; Sasakura Y.
Germline transgenesis of the chordate Ciona intestinalis with hyperactive variants of sleeping beauty transposable element
Developmental Dynamics 242 (1): 30-43 (2013-01)


Muenthaisong S.; Ujhelly O.; Polgar Z.; Varga E.; Ivics Z.; Pirity M.K.; Dinnyes A.
Generation of mouse induced pluripotent stem cells from different genetic backgrounds using Sleeping beauty transposon mediated gene transfer
Experimental Cell Research 318 (19): 2482-2489 (2012-11-15)

Voigt K.; Gogol-Doering A.; Miskey C.; Chen W.; Cathomen T.; Izsvak Z.; Ivics Z.
Retargeting Sleeping Beauty transposon insertions by engineered zinc finger DNA-binding domains
Molecular Therapy 20 (10): 1852-1862 (2012-10)

Ammar I.; Gogol-Doering A.; Miskey C.; Chen W.; Cathomen T.; Izsvak Z.; Ivics Z.
Retargeting transposon insertions by the adeno-associated virus Rep protein
Nucleic Acids Research 40 (14): 6693-6712 (2012-08-01)

Johnen S.; Izsvak Z.; Stocker M.; Harmening N.; Salz A.K.; Walter P.; Thumann G.
Sleeping Beauty transposon-mediated transfection of retinal and iris pigment epithelial cells
Investigative Ophthalmology & Visual Science 53 (8): 4787-4796 (2012-07-18)

Petrakis S.; Rasko T.; Mates L.; Ivics Z.; Izsvak Z.; Kouzi-Koliakou K.; Koliakos G.
Gateway compatible transposon vector to genetically modify human embryonic kidney and adipose-derived stromal cells
Biotechnology Journal 7 (7): 891-897 (2012-07)

Swierczek M.; Izsvak Z.; Ivics Z.
The Sleeping Beauty transposon system for clinical applications
Expert Opinion on Biological Therapy 12 (2): 139-153 (2012-02)

Ammar I.; Izsvak Z.; Ivics Z.
The sleeping beauty transposon toolbox
Methods in Molecular Biology 859: 229-240 (2012-01-31)


Garrels W.; Holler S.; Taylor U.; Herrmann D.; Struckmann C.; Klein S.; Barg-Kues B.; Nowak-Imialek M.; Ehling C.; Rath D.; Ivics Z.; Niemann H.; Kues W.A.
Genotype-independent transmission of transgenic fluorophore protein by boar spermatozoa
PLoS ONE 6 (11): e27563 (2011-11-16)

Ivics Z.
Recombinase technology for gene therapy
Current Gene Therapy 11 (5): 331 (2011-10-01)

Ivics Z.; Izsvak Z.; Medrano G.; Chapman K.M.; Hamra F.K.
Sleeping Beauty transposon mutagenesis in rat spermatogonial stem cells
Nature Protocols 6 (10): 1521-1535 (2011-10)

Ivics Z.; Izsvak Z.
Nonviral gene delivery with the Sleeping Beauty transposon system
Human Gene Therapy 22 (9): 1043-1051 (2011-09)

Jin Z.; Maiti S.; Huls H.; Singh H.; Olivares S.; Mates L.; Izsvak Z.; Ivics Z.; Lee D.A.; Champlin R.E.; Cooper L.J.
The hyperactive Sleeping Beauty transposase SB100X improves the genetic modification of T cells to express a chimeric antigen receptor
Gene Therapy 18 (9): 849-856 (2011-09)

Galla M.; Schambach A.; Falk C.S.; Maetzig T.; Kuehle J.; Lange K.; Zychlinski D.; Heinz N.; Brugman M.H.; Goehring G.; Izsvak Z.; Ivics Z.; Baum C.
Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery
Nucleic Acids Research 39 (16): 7147-7160 (2011-09-01)

Garrels W.; Mates L.; Holler S.; Dalda A.; Taylor U.; Petersen B.; Niemann H.; Izsvak Z.; Ivics Z.; Kues W.A.
Germline transgenic pigs by Sleeping Beauty transposition in porcine zygotes and targeted integration in the pig genome
PLoS ONE 6 (8): e23573 (2011-08-29)

Moldt B.; Miskey C.; Staunstrup N.H.; Gogol-Doering A.; Bak R.O.; Sharma N.; Mates L.; Izsvak Z.; Chen W.; Ivics Z.; Mikkelsen J.G.
Comparative genomic integration profiling of Sleeping Beauty transposons mobilized with high efficacy from integrase-defective lentiviral vectors in primary human cells
Molecular Therapy 19 (8): 1499-1510 (2011-08)

Ivics Z.; Izsvak Z.; Chapman K.M.; Hamra F.K.
Sleeping Beauty transposon mutagenesis of the rat genome in spermatogonial stem cells
Methods 53 (4): 356-365 (2011-04)

Kolacsek O.; Krizsik V.; Schamberger A.; Erdei Z.; Apati A.; Varady G.; Mates L.; Izsvak Z.; Ivics Z.; Sarkadi B.; Orban T.I.
Reliable transgene-independent method for determining Sleeping Beauty transposon copy numbers
Mobile DNA 2 (1): 5 (2011-03-03)

Grabundzija I.; Izsvak Z.; Ivics Z.
Insertional engineering of chromosomes with Sleeping Beauty transposition: an overview
Methods in Molecular Biology 738: 69-85 (2011)

Garrels W.; Holler S.; Ivics Z.; Niemann H.; Kues W.A.
Transgene Expression durch zytoplasmatische Injektion von Plasmiden und Transposon-basierten Konstrukten in Saeugerembryonen [Transgenetic expression by cytoplasmic injection of plasmids and transĀ­poson-based constructs in mammalian embryos]
Zuechtungskunde 83 (1): 47-67 (2011-01)


Ivics Z.; Izsvak Z.
The expanding universe of transposon technologies for gene and cell engineering
Mobile DNA 1 (1): 25 (2010-12-07)

de Silva S.; Mastrangelo M.A.; Lotta L.T.; Burris C.A.; Izsvak Z.; Ivics Z.; Bowers W.J.
Herpes simplex virus/Sleeping Beauty Vector-based embryonic gene transfer using the HSB5 mutant: loss of apparent transposition hyperactivity in vivo
Human Gene Therapy 21 (11): 1603-1613 (2010-11-19)

Belay E.; Matrai J.; Acosta-Sanchez A.; Ma L.; Quattrocelli M.; Mates L.; Sancho-Bru P.; Geraerts M.; Yan B.; Vermeesch J.; Rincon M.Y.; Samara-Kuko E.; Ivics Z.; Verfaillie C.M.; Sampaolesi M.; Izsvak Z.; Vandendriessche T.; Chuah M.K.
Novel hyperactive transposons for genetic modification of induced puripotent and adult stem cells: a non-viral paradigm for coaxed differentiation
Stem Cells 28 (10): 1760-1771 (2010-10)

Albieri I.; Onorati M.; Calabrese G.; Moiana A.; Biasci D.; Badaloni A.; Camnasio S.; Spiliotopoulos D.; Ivics Z.; Cattaneo E.; Consalez G.G.
A DNA-transposon-based approach to functional screening in neural stem cells
Journal of Biotechnology 150 (1): 11-21 (2010-10-01)

Izsvak Z.; Hackett P.B.; Cooper L.J.; Ivics Z.
Translating Sleeping Beauty transposition into cellular therapies: Victories and challenges
BioEssays 32 (9): 756-767 (2010-09)

Kuzmin D.; Gogvadze E.; Kholodenko R.; Grzela D.P.; Mityaev M.; Vinogradova T.; Kopantzev E.; Malakhova G.; Suntsova M.; Sokov D.; Ivics Z.; Buzdin A.
Novel strong tissue specific promoter for gene expression in human germ cells
BMC Biotechnology 10 (1): 58 (2010-08-17)

Ivics Z.; Izsvak Z.
Repetitive elements and genome instability
Seminars in Cancer Biology 20 (4): 197-199 (2010-08)

Izsvak Z.; Froehlich J.; Grabundzija I.; Shirley J.R.; Powell H.M.; Chapman K.M.; Ivics Z.; Hamra F.K.
Generating knockout rats by transposon mutagenesis in spermatogonial stem cells
Nature Methods 7 (6): 443-445 (2010-06)

Grabundzija I.; Irgang M.; Mates L.; Belay E.; Matrai J.; Gogol-Doering A.; Kawakami K.; Chen W.; Ruiz P.; Chuah M.K.; Vandendriessche T.; Izsvak Z.; Ivics Z.
Comparative analysis of transposable element vector systems in human cells
Molecular Therapy 18 (6): 1200-1209 (2010-06)

Schebelle L.; Wolf C.; Stribl C.; Javaheri T.; Schnuetgen F.; Ettinger A.; Ivics Z.; Hansen J.; Ruiz P.; von Melchner H.; Wurst W.; Floss T.
Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps
Nucleic Acids Research 38 (9): e106 (2010-05)

Schumann G.G.; Gogvadze E.V.; Osanai-Futahashi M.; Kuroki A.; Muenk C.; Fujiwara H.; Ivics Z.; Buzdin A.A.
Unique functions of repetitive transcriptomes
International Review of Cell and Molecular Biology 285: 115-188 (2010)

Wang Y.; Liska F.; Gosele C.; Sedova L.; Kren V.; Krenova D.; Ivics Z.; Huebner N.; Izsvak Z.
A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains
Genome Research 20 (1): 19-27 (2010-01)


Izsvak Z.; Chuah M.K.; VandenDriessche T.; Ivics Z.
Efficient stable gene transfer into human cells by Sleeping Beauty transposon vectors
Methods 49 (3): 287-297 (2009-11)

Vandendriessche T.; Ivics Z.; Izsvak Z.; Chuah M.K.
Emerging potential of transposons for gene therapy and generation of induced pluripotent stem cells
Blood 114 (8): 1461-1468 (2009-08-20)

Xue X.; Huang X.; Nodland S.E.; Mates L.; Ma L.; Izsvak Z.; Ivics Z.; Lebien T.W.; McIvor R.S.; Wagner J.E.; Zhou X.
Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system
Blood 114 (7): 1319-1330 (2009-08-13)

Staunstrup N.H.; Moldt B.; Mates L.; Villesen P.; Jakobsen M.; Ivics Z.; Izsvak Z.; Mikkelsen J.G.
Hybrid lentivirus-transposon vectors with a random integration profile in human cells
Molecular Therapy 17 (7): 1205-1214 (2009-07)

Ivics Z.; Li M.A.; Mates L.; Boeke J.D.; Nagy A.; Bradley A.; Izsvak Z.
Transposon-mediated genome manipulation in vertebrates
Nature Methods 6 (6): 415-422 (2009-06)

Mates L.; Chuah M.K.; Belay E.; Jerchow B.; Manoj N.; Acosta-Sanchez A.; Grzela D.P.; Schmitt A.; Becker K.; Matrai J.; Ma L.; Samara-Kuko E.; Gysemans C.; Pryputniewicz D.; Miskey C.; Fletcher B.; Vandendriessche T.; Ivics Z.; Izsvak Z.
Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates
Nature Genetics 41 (6): 753-761 (2009-06)

Ivics Z.
Genomic parasites and genome evolution
Genome Biology 10 (4): 306 (2009-04-15)

Sinzelle L.; Izsvak Z.; Ivics Z.
Molecular domestication of transposable elements: From detrimental parasites to useful host genes
Cellular and Molecular Life Sciences 66 (6): 1073-1093 (2009-03)

Orban T.I.; Apati A.; Nemeth A.; Varga N.; Krizsik V.; Schamberger A.; Szebenyi K.; Erdei Z.; Varady G.; Karaszi E.; Homolya L.; Nemet K.; Gocza E.; Miskey C.; Mates L.; Ivics Z.; Izsvak Z.; Sarkadi B.
Applying a "double-feature" promoter to identify cardiomyocytes differentiated from human embryonic stem cells following transposon-based gene delivery
Stem Cells 27 (5): 1077-1087 (2009-02-20)

Ohlfest J.R.; Ivics Z.; Izsvak Z.
Transposable elements as plasmid-based vectors for long-term gene transfer into tumors
Methods in Molecular Biology 542 (Part 2): 105-116 (2009)

Walisko O.; Jursch T.; Izsvak Z.; Ivics Z.
Transposon-host cell interactions in the regulation of Sleeping Beauty transposition
Genome Dynamics and Stability 4: 109-132 (2009)

Izsvak Z.; Wang Y.; Ivics Z.
Interactions of transposons with the cellular DNA repair machinery
Genome Dynamics and Stability 4: 133-176 (2009)


Voigt K.; Izsvak Z.; Ivics Z.
Targeted gene insertion for molecular medicine
Journal of Molecular Medicine 86 (11): 1205-1219 (2008-11)

Aitman T.J.; Critser J.K.; Cuppen E.; Dominiczak A.; Fernandez-Suarez X.M.; Flint J.; Gauguier D.; Geurts A.M.; Gould M.; Harris P.C.; Holmdahl R.; Huebner N.; Izsvak Z.; Jacob H.J.; Kuramoto T.; Kwitek A.E.; Marrone A.; Mashimo T.; Moreno C.; Mullins J.; Mullins L.; Olsson T.; Pravenec M.; Riley L.; Saar K.; Serikawa T.; Shull J.D.; Szpirer C.; Twigger S.N.; Voigt B.; Worley K.C.
Progress and prospects in rat genetics: a community view
Nature Genetics 40 (5): 516-22 (2008-05)

Sinzelle L.; Kapitonov V.V.; Grzela D.P.; Jursch T.; Jurka J.; Izsvak Z.; Ivics Z.
Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes
Proceedings of the National Academy of Sciences of the United States of America 105 (12): 4715-4720 (2008-03-25)

Walisko O.; Schorn A.; Rolfs F.; Devaraj A.; Miskey C.; Izsvak Z.; Ivics Z.
Transcriptional activities of the Sleeping Beauty transposon and shielding its genetic cargo with insulators
Molecular Therapy 16 (2): 359-369 (2008-02)

Takeda J.; Izsvak Z.; Ivics Z.
Insertional mutagenesis of the mouse germline with Sleeping Beauty transposition
Methods in Molecular Biology 435: 109-125 (2008)


Mates L.; Izsvak Z.; Ivics Z.
Technology transfer from worms and flies to vertebrates: transposition-based genome manipulations and their future perspectives
Genome Biology 8 Suppl 1: S1 (2007-10-31)

Miskey C.; Papp B.; Mates L.; Sinzelle L.; Keller H.; Izsvak Z.; Ivics Z.
The Ancient Mariner Sails Again: Transposition of the Human Hsmar1 Element by a Reconstructed Transposase and Activities of the SETMAR Protein on Transposon Ends
Molecular and Cellular Biology 27 (12): 4589-4600 (2007-06-15)

Ivics Z.; Katzer A.; Stuewe E.E.; Fiedler D.; Knespel S.; Izsvak Z.
Targeted Sleeping Beauty transposition in human cells
Molecular Therapy 15 (6): 1137-1144 (2007-06)


Ivics Z.; Izsvak Z.
Transposons for gene therapy!
Current Gene Therapy 6 (5): 593-607 (2006-10)

Izsvak Z.; Ivics Z.; Mates L.
Hungary's 'reforms' are threatening basic science
Nature 443 (7110): 394 (2006-09-28)

Walisko O.; Izsvak Z.; Szabo K.; Kaufman C.D.; Herold S.; Ivics Z.
Sleeping Beauty transposase modulates cell-cycle progression through interaction with Miz-1
Proceedings of the National Academy of Sciences of the United States of America 103 (11): 4062-4067 (2006-03-14)

Ivics Z.; Walisko O.; Izsvak Z.
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2 : 1915-1919 (2006)


Kaufman C.D.; Izsvak Z.; Katzer A.; Ivics Z.
Frog Prince transposon-based RNAi vectors mediate efficient gene knockdown in human cells
Journal of RNAi and Gene Silencing 1 (2): 97-104 (2005-10)

Izsvak Z.; Ivics Z.
Sleeping Beauty hits them all: transposon-mediated saturation mutagenesis in the mouse germline
Nature Methods 2 (10): 735-736 (2005-10)

Miskey C.; Izsvak Z.; Kawakami K.; Ivics Z.
DNA transposons in vertebrate functional genomics
Cellular and Molecular Life Sciences 62 (6): 629-641 (2005-03)

Ivics Z.; Izsvak Z.
A whole lotta jumpin' goin' on: new transposon tools for vertebrate functional genomics
Trends in Genetics 21 (1): 8-11 (2005-01-01)


Zayed H.; Izsvak Z.; Walisko O.; Ivics Z.
Development of hyperactive Sleeping Beauty transposon vectors by mutational analysis
Molecular Therapy 9 (2): 292-304 (2004-02-01)

Izsvak Z.; Ivics Z.
Sleeping Beauty transposition: biology and applications for molecular therapy
Molecular Therapy 9 (2): 147-156 (2004-02-01)

Izsvak Z.; Stuewe E.E.; Fiedler D.; Katzer A.; Jeggo P.A.; Ivics Z.
Healing the wounds inflicted by Sleeping Beauty transposition by double-strand break repair in mammalian somatic cells
Molecular Cell 13 (2): 279-290 (2004-01-01)

Ivics Z.; Izsvak Z.
Transposable elements for transgenesis and insertional mutagenesis in vertebrates: a contemporary review of experimental strategies
Mobile Genetic Elements: Protocols and Genomic Applications 260: 255-276 (2004-01-01)

Ivics Z.; Kaufman C.D.; Zayed H.; Miskey C.; Walisko O.; Izsvak Z.
The Sleeping Beauty transposable element: evolution, regulation and genetic applications
Current Issues in Molecular Biology 6 (1): 43-55 (2004-01-01)


Miskey C.; Izsvak Z.; Plasterk R.H.; Ivics Z.
The Frog Prince: a reconstructed transposon from Rana pipiens with high transpositional activity in vertebrate cells
Nucleic Acids Research 31 (23): 6873-6881 (2003-12-01)

Zayed H.; Izsvak Z.; Khare D.; Heinemann U.; Ivics Z.
The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition
Nucleic Acids Research 31 (9): 2313-2322 (2003-05-01)


Vigdal T.J.; Kaufman C.D.; Izsvak Z.; Voytas D.F.; Ivics Z.
Common physical properties of DNA affecting target site selection of Sleeping Beauty and other Tc1/mariner transposable elements
Journal of Molecular Biology 323 (3): 441-452 (2002-10-25)

Izsvak Z.; Khare D.; Behlke J.; Heinemann U.; Plasterk R.H.; Ivics Z.
Involvement of a bifunctional, paired-like DNA-binding domain and a transpositional enhancer in Sleeping Beauty transposition
Journal of Biological Chemistry 277 (37): 34581-34588 (2002-09-13)


Izsvak Z.; Ivics Z.; Plasterk R.H.
Sleeping Beauty, a wide host-range transposon vector for genetic transformation in vertebrates
Journal of Molecular Biology 302: 93-102 (2000-09-08)

Yant S.R.; Meuse L.; Chiu W.; Ivics Z.; Izsvak Z.; Kay M.A.
Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system
Nature Genetics 25 (1): 35-41 (2000-05-01)


Luo G.; Ivics Z.; Izsvak Z.; Bradley A.
Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells
Proceedings of the National Academy of Sciences of the United States of America 95 (18): 10769-10773 (1998-09-01)


Izsvak Z.; Ivics Z.; Garcia-Estefania D.; Fahrenkrug S.C.; Hackett P.B.
DANA elements: a family of composite, tRNA-derived short interspersed DNA elements associated with mutational activities in zebrafish (Danio rerio)
Proceedings of the National Academy of Sciences of the United States of America 93 (3): 1077-1081 (1996-02-06)


Izsvak Z.; Ivics Z.; Hackett P.B.
Characterization of a Tc1-like transposable element in zebrafish (Danio rerio)
Molecular and General Genetics 247 (3): 312-322 (1995-05-10)


Izsvak Z.; Jobbagy Z.; Duda E.
Purification and characterization of CeqI restriction endonuclease
Zeitschrift fuer Naturforschung C, A Journal of Biosciences 47: 830-834 (1992-11-01)