Publications



2017

Riesner K.; Shi Y.; Jacobi A.; Kraeter M.; Kalupa M.; McGearey A.; Mertlitz S.; Cordes S.; Schrezenmeier J.F.; Mengwasser J.; Westphal S.; Perez-Hernandez D.; Schmitt C.; Dittmar G.; Guck J.; Penack O.
Initiation of acute graft-versus-host disease by angiogenesis
Blood 129 (14): 2021-2032 (2017-04-06)



Du J.; Neuenschwander M.; Yu Y.; Daebritz J.H.M.; Neuendorff N.R.; Schleich K.; Bittner A.; Milanovic M.; Beuster G.; Radetzki S.; Specker E.; Reimann M.; Rosenbauer F.; Mathas S.; Lohneis P.; Hummel M.; Doerken B.; von Kries J.P.; Lee S.; Schmitt C.A.
Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin's lymphoma
Blood 129 (1): 71-81 (2017-01-12)



2016

Young E.; Noerenberg D.; Mansouri L.; Ljungstroem V.; Frick M.; Sutton L.A.; Blakemore S.J.; Galan-Sousa J.; Plevova K.; Baliakas P.; Rossi D.; Clifford R.; Roos-Weil D.; Navrkalova V.; Doerken B.; Schmitt C.A.; Smedby K.E.; Juliusson G.; Giacopelli B.; Blachly J.S.; Belessi C.; Panagiotidis P.; Chiorazzi N.; Davi F.; Langerak A.W.; Oscier D.; Schuh A.; Gaidano G.; Ghia P.; Xu W.; Fan L.; Bernard O.A.; Nguyen-Khac F.; Rassenti L.; Li J.; Kipps T.J.; Stamatopoulos K.; Pospisilova S.; Zenz T.; Oakes C.C.; Strefford J.C.; Rosenquist R.; Damm F.
EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia
Leukemia : (2016-11-28)



Fan D.N.Y.; Schmitt C.A.
Detecting markers of therapy-induced senescence in cancer cells
Methods in Molecular Biology 1534: 41-52 (2016-11-04)



Jaeger C.; Hoffmann F.; Schmitt C.A.; Lisec J.
Automated annotation and evaluation of in-source mass spectra in GC/atmospheric pressure chemical ionization-MS-based metabolomics
Analytical Chemistry 88 (19): 9386-9390 (2016-10-04)



Qi J.; Yu Y.; Akilli Oeztuerk O.; Holland J.D.; Besser D.; Fritzmann J.; Wulf-Goldenberg A.; Eckert K.; Fichtner I.; Birchmeier W.
New Wnt/{beta}-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals
Gut 65 (10): 1690-1701 (2016-10)



Schmitt C.A.
The persistent dynamic secrets of senescence
Nature Cell Biology 18 (9): 913-915 (2016-09)



Lisec J.; Hoffmann F.; Schmitt C.; Jaeger C.
Extending the dynamic range in metabolomics experiments by automatic correction of peaks exceeding the detection limit
Analytical Chemistry 88 (15): 7487-7492 (2016-08-02)



Knittel G.; Liedgens P.; Korovkina D.; Seeger J.M.; Al-Baldawi Y.; Al-Maarri M.; Fritz C.; Vlantis K.; Bezhanova S.; Scheel A.H.; Wolz O.O.; Reimann M.; Moeller P.; Lopez C.; Schlesner M.; Lohneis P.; Weber A.N.R.; Truemper L.; Staudt L.M.; Ortmann M.; Pasparakis M.; Siebert R.; Schmitt C.A.; Klatt A.R.; Wunderlich F.T.; Schaefer S.C.; Persigehl T.; Montesinos-Rongen M.; Odenthal M.; Buettner R.; Frenzel L.P.; Kashkar H.; Reinhardt H.C.
B cell-specific conditional expression of Myd88(p.L252P) leads to the development of diffuse large B cell lymphoma in mice
Blood 127 (22): 2732-2741 (2016-06-02)



Daebritz J.H.M.; Yu Y.; Milanovic M.; Schoenlein M.; Rosenfeldt M.T.; Doerr J.R.; Kaufmann A.M.; Dorken B.; Schmitt C.A.
CD20-targeting immunotherapy promotes cellular senescence in B-cell lymphoma
Molecular Cancer Therapeutics 15 (5): 1074-1081 (2016-05)



Choi M.; Fink S.; Prasad V.; Anagnostopoulos I.; Reinke P.; Schmitt C.A.
T cell PTLD successfully treated with single-agent brentuximab vedotin first-line therapy
Transplantation 100 (3): e8-e10 (2016-03)



Kruse J.M.; Jenning T.; Rademacher S.; Arnold R.; Schmitt C.A.; Joerres A.; Enghard P.; Oppert M.
Neutropenic sepsis in the ICU: Outcome predictors in a two-phase model and microbiology findings
Critical Care Research and Practice 2016: 8137850 (2016)




Metabolism in cancer
Recent Results in Cancer Research 207: (2016)



2015

Hu F.; a Dzaye O.D.; Hahn A.; Yu Y.; Scavetta R.J.; Dittmar G.; Kaczmarek A.K.; Dunning K.R.; Ricciardelli C.; Rinnenthal J.L.; Heppner F.L.; Lehnardt S.; Synowitz M.; Wolf S.A.; Kettenmann H.
Glioma-derived versican promotes tumor expansion via glioma-associated microglial/macrophages Toll-like receptor 2 signaling
Neuro-Oncology 17 (2): 200-210 (2015-02)



2014

Boeck B.C.; Stein U.; Schmitt C.A.; Augustin H.G.
Mouse models of human cancer
Cancer Research 74 (17): 4671-4675 (2014-09-01)



Jing H.; Lee S.
NF-{kappa}B in cellular senescence and cancer treatment
Molecules and Cells 37 (3): 189-195 (2014-03-31)



2013

Doerr J.R.; Yu Y.; Milanovic M.; Beuster G.; Zasada C.; Daebritz J.H.M.; Lisec J.; Lenze D.; Gerhardt A.; Schleicher K.; Kratzat S.; Purfuerst B.; Walenta S.; Mueller-Klieser W.; Graeler M.; Hummel M.; Keller U.; Buck A.K.; Doerken B.; Willmitzer L.; Reimann M.; Kempa S.; Lee S.; Schmitt C.A.
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
Nature 501 (7467): 421-425 (2013-09-19)



Shortt J.; Martin B.P.; Newbold A.; Hannan K.M.; Devlin J.R.; Baker A.J.; Ralli R.; Cullinane C.; Schmitt C.A.; Reimann M.; Hall M.N.; Wall M.; Hannan R.D.; Pearson R.B.; McArthur G.A.; Johnstone R.W.
Combined inhibition of PI3K-related DNA-damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas
Blood 121 (15): 2964-2974 (2013-04-11)



2012

Bywater M.J.; Poortinga G.; Sanij E.; Hein N.; Peck A.; Cullinane C.; Wall M.; Cluse L.; Drygin D.; Anderes K.; Huser N.; Proffitt C.; Bliesath J.; Haddach M.; Schwaebe M.K.; Ryckman D.M.; Rice W.G.; Schmitt C.; Lowe S.W.; Johnstone R.W.; Pearson R.B.; McArthur G.A.; Hannan R.D.
Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53
Cancer Cell 22 (1): 51-65 (2012-07-10)



Gerbitz A.; Sukumar M.; Helm F.; Wilke A.; Friese C.; Fahrenwaldt C.; Lehmann F.M.; Loddenkemper C.; Kammertoens T.; Mautner J.; Schmitt C.A.; Blankenstein T.; Bornkamm G.W.
Stromal interferon-{gamma} signaling and cross-presentation are required to eliminate antigen-loss variants of B cell lymphomas in mice
PLoS ONE 7 (3): e34552 (2012-03-30)



Kaiser A.D.; Schuster K.; Gadiot J.; Borkner L.; Daebritz H.; Schmitt C.; Andreesen R.; Blank C.
Reduced tumor-antigen density leads to PD-1/PD-L1 mediated impairment of partially exhausted CD8(+) T cells
European Journal of Immunology 42 (3): 662-671 (2012-03)



2011

Lee S.; Schmitt C.A.; Reimann M.
The Myc/macrophage tango: Oncogene-induced senescence, Myc style
Seminars in Cancer Biology 21 (6): 377-384 (2011-12)



Jing H.; Kase J.; Doerr J.R.; Milanovic M.; Lenze D.; Grau M.; Beuster G.; Ji S.; Reimann M.; Lenz P.; Hummel M.; Doerken B.; Lenz G.; Scheidereit C.; Schmitt C.A.; Lee S.
Opposing roles of NF-{kappa}B in anti-cancer treatment outcome unveiled by cross-species investigations
Genes & Development 25 (20): 2137-2146 (2011-10-15)



Reimann M.; Schmitt C.A.; Lee S.
Non-cell-autonomous tumor suppression: oncogene-provoked apoptosis promotes tumor cell senescence via stromal crosstalk
Journal of Molecular Medicine 89 (9): 869-875 (2011-09)



2010

Haugstetter A.M.; Loddenkemper C.; Lenze D.; Groene J.; Standfuss C.; Petersen I.; Doerken B.; Schmitt C.A.
Cellular senescence predicts treatment outcome in metastasised colorectal cancer
British Journal of Cancer 103 (4): 505-509 (2010-08-10)



Rohwer N.; Dame C.; Haugstetter A.M.; Wiedenmann B.; Detjen K.; Schmitt C.A.; Cramer T.
Hypoxia-inducible factor 1 alpha determines gastric cancer chemosensitivity via modulation of p53 and NF-kappa B
PLoS ONE 5 (8): e12038 (2010-08-10)



Reimann M.; Lee S.; Loddenkemper C.; Doerr J.R.; Tabor V.; Aichele P.; Stein H.; Doerken B.; Jenuwein T.; Schmitt C.A.
Tumor stroma-derived TGF-beta limits Myc-driven lymphomagenesis via Suv39h1-dependent senescence
Cancer Cell 17 (3): 262-272 (2010-03-16)



2007

Bouchard C.; Lee S.; Paulus-Hock V.; Loddenkemper C.; Eilers M.; Schmitt C.A.
FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf
Genes & Development 21 (21): 2775-2787 (2007-11-01)



Reimann M.; Loddenkemper C.; Rudolph C.; Schildhauer I.; Teichmann B.; Stein H.; Schlegelberger B.; Doerken B.; Schmitt C.A.
The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo
Blood 110 (8): 2996-3004 (2007-10-15)



Reimann M.; Schmitt C.A.
Apoptosis and cancer therapy
Apoptosis, Cell Signaling, and Human Diseases 1: 303-320 (2007)



Schmitt C.A.
Cellular senescence and cancer treatment
Biochimica et Biophysica Acta - Reviews on Cancer 1775 (1): 5-20 (2007-01)



2006

Braig M.; Schmitt C.A.
Oncogene-induced senescence: putting the brakes on tumor development
Cancer Research 66 (6): 2881-2884 (2006-03-15)



Lee S.; Schmitt C.A.
Mouse models in cancer research
Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts 2: 671-701 (2006-02-06)



2005

Braig M.; Lee S.; Loddenkemper C.; Rudolph C.; Peters A.H.; Schlegelberger B.; Stein H.; Doerken B.; Jenuwein T.; Schmitt C.A.
Oncogene-induced senescence as an initial barrier in lymphoma development
Nature 436 (7051): 660-665 (2005-08-04)



Helmrich A.; Lee S.; O'Brien P.; Doerken B.; Lowe S.W.; Schroeck E.; Schmitt C.A.
Recurrent chromosomal aberrations in INK4a/ARF defective primary lymphomas predict drug responses in vivo
Oncogene 24: 4174-4182 (2005-01-01)



2004

Subklewe M.; Nagy M.; Schoch C.; Jenisch S.; Siebert R.; Gesk S.; Neuhaus P.; Doerken B.; Schmidt C.A.
Extramedullary manifestation of a donor-derived acute myeloid leukemia in a liver transplant patient
Leukemia 18 (12): 2050-2053 (2004-10-07)



Lee S.; Doerken B.; Schmitt C.A.
Extracorporeal photopheresis in graft-versus-host disease: ultraviolet radiation mediates T cell senescence in vivo
Transplantation 78 (3): 484-485 (2004-08-15)



Kahlem P.; Doerken B.; Schmitt C.A.
Cellular senescence in cancer treatment: friend or foe?
Journal of Clinical Investigation 113 (2): 169-174 (2004-01)



2003

Maier M.; Maier-Bosse T.; Schulz C.U.; Steinborn M.; Schmitt C.A.; Kleen M.; Staebler A.
Inter and intraobserver variability in DePalma's classification of shoulder calcific tendinitis
Journal of Rheumatology 30 (5): 1029-1031 (2003-05)



Schmitt C.A.
Senescence apoptosis and therapy - cutting the lifelines of cancer
Nature Reviews Cancer 3 (4): 286-295 (2003-04)



Lee S.; Schmitt C.A.
Chemotherapy response and resistance
Current Opinion in Genetics & Development 13 (1): 90-96 (2003-02)