Publications



2017

Schulte K.W.; Green E.; Wilz A.; Platten M.; Daumke O.
Structural basis for aryl hydrocarbon receptor-mediated gene activation
Structure : (2017-06-09)



Hessenberger M.; Zerbes R.M.; Rampelt H.; Kunz S.; Xavier A.H.; Purfuerst B.; Lilie H.; Pfanner N.; van der Laan M.; Daumke O.
Regulated membrane remodeling by Mic60 controls formation of mitochondrial crista junctions
Nature Communications 8: 15258 (2017-05-31)



Melo A.A.; Hegde B.G.; Shah C.; Larsson E.; Isas J.M.; Kunz S.; Lundmark R.; Langen R.; Daumke O.
Structural insights into the activation mechanism of dynamin-like EHD ATPases
Proceedings of the National Academy of Sciences of the United States of America 114 (22): 5629-5634 (2017-05-30)



Daumke O.; Roux A.
Mitochondrial homeostasis: How do dimers of mitofusins mediate mitochondrial fusion?
Current Biology 27 (9): R353-R356 (2017-05-08)



Jerke U.; Marino S.F.; Daumke O.; Kettritz R.
Characterization of the CD177 interaction with the ANCA antigen proteinase 3
Scientific Reports 7: 43328 (2017-02-27)



Paul F.; Zauber H.; von Berg L.; Rocks O.; Daumke O.; Selbach M.
Quantitative GTPase affinity purification identifies Rho family protein interaction partners
Molecular & Cellular Proteomics 16 (1): 73-85 (2017-01-01)



2016

Antonny B.; Burd C.; De Camilli P.; Chen E.; Daumke O.; Faelber K.; Ford M.; Frolov V.A.; Frost A.; Hinshaw J.E.; Kirchhausen T.; Kozlov M.M.; Lenz M.; Low H.H.; McMahon H.; Merrifield C.; Pollard T.D.; Robinson P.J.; Roux A.; Schmid S.
Membrane fission by dynamin: what we know and what we need to know
EMBO Journal 35 (21): 2270-2284 (2016-11-02)



Noel J.K.; Whitford P.C.
How EF-Tu can contribute to efficient proofreading of aa-tRNA by the ribosome
Nature Communications 7: 13314 (2016-10-31)



Arumughan A.; Roske Y.; Barth C.; Lleras Forero L.; Bravo-Rodriguez K.; Redel Al.; Kostova S.; McShane E.; Opitz R.; Faelber K.; Rau K.; Mielke T.; Daumke O.; Selbach M.; Sanchez-Garcia E.; Rocks O.; Panakova D.; Heinemann U.; Wanker E.E.
Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers
Nature Communications 7: 13047 (2016-10-20)



Eccles R.L.; Czajkowski M.T.; Barth C.; Mueller P.M.; McShane E.; Grunwald S.; Beaudette P.; Mecklenburg N.; Volkmer R.; Zuehlke K.; Dittmar G.; Selbach M.; Hammes A.; Daumke O.; Klussmann E.; Urbe S.; Rocks O.
Bimodal antagonism of PKA signalling by ARHGAP36
Nature Communications 7: 12963 (2016-10-07)



Daumke O.; Unger V.M.
Protein-mediated membrane remodeling
Journal of Structural Biology 196 (1): 1-2 (2016-10)



Lin X.C.; Noel J.K.; Wang Q.H.; Ma J.P.; Onuchic J.N.
Lowered pH leads to fusion peptide release and a highly dynamic intermediate of influenza hemagglutinin
Journal of Physical Chemistry B 120 (36): 9654-9660 (2016-09-15)



Daumke O.; Praefcke G.J.
Mechanisms of GTP hydrolysis and conformational transitions in the dynamin superfamily
Biopolymers 105 (8): 580-593 (2016-08)



Goetz F.; Roske Y.; Schulz M.S.; Autenrieth K.; Bertinetti D.; Faelber K.; Zuehlke K.; Kreuchwig A.; Kennedy E.; Krause G.; Daumke O.; Herberg F.W.; Heinemann U.; Klussmann E.
AKAP18:PKA-RII{alpha} structure reveals crucial anchor points for recognition of regulatory subunits of PKA
Biochemical Journal 473 (13): 1881-1894 (2016-06-28)



Noel J.K.; Levi M.; Raghunathan M.; Lammert H.; Hayes R.L.; Onuchic J.N.; Whitford P.C.
SMOG 2: A versatile software package for generating structure-based models
PLoS Computational Biology 12 (3): e1004794 (2016-03-10)



Olal D.; Daumke O.
Structure of the hantavirus nucleoprotein provides insights into the mechanism of RNA encapsidation
Cell Reports 14 (9): 2092-2099 (2016-03-08)



Schulte K.; Pawlowski N.; Faelber K.; Froehlich C.; Howard J.; Daumke O.
The immunity-related GTPase Irga6 dimerizes in a parallel head-to-head fashion
BMC Biology 14 (1): 14 (2016-03-02)



Marino S.F.; Olal D.; Daumke O.
A complex water network contributes to high-affinity binding in an antibody-antigen interface
Data in Brief 6: 394-397 (2016-03)



Baranovic J.; Chebli M.; Salazar H.; Carbone A.L.; Faelber K.; Lau A.Y.; Daumke O.; Plested A.J.R.
Dynamics of the ligand binding domain layer during AMPA receptor activation
Biophysical Journal 110 (4): 896-911 (2016-02-23)



Noel J.K.; Morcos F.; Onuchic J.N.
Sequence co-evolutionary information is a natural partner to minimally-frustrated models of biomolecular dynamics
F1000 Research 5 (F1000 Faculty Rev): 106 (2016-01-26)



2015

Reubold T.F.; Faelber K.; Plattner N.; Posor Y.; Ketel K.; Curth U.; Schlegel J.; Anand R.; Manstein D.J.; Noe F.; Haucke V.; Daumke O.; Eschenburg S.
Crystal structure of the dynamin tetramer
Nature 525 (7569): 404-408 (2015-09-17)



Senju Y.; Rosenbaum E.; Shah C.; Hamada-Nakahara S.; Itoh Y.; Yamamoto K.; Hanawa-Suetsugu K.; Daumke O.; Suetsugu S.
Phosphorylation of PACSIN2 by protein kinase C triggers the removal of caveolae from the plasma membrane
Journal of Cell Science 128 (15): 2766-2780 (2015-08-01)



Oden F.; Marino S.F.; Brand J.; Scheu S.; Kriegel C.; Olal D.; Takvorian A.; Westermann J.; Yilmaz B.; Hinz M.; Daumke O.; Hoepken U.E.; Mueller G.; Lipp M.
Potent anti-tumor response by targeting B cell maturation antigen (BCMA) in a mouse model of multiple myeloma
Molecular Oncology 9 (7): 1348-1358 (2015-08)



Geisberger S.; Maschke U.; Gebhardt M.; Kleinewietfeld M.; Manzel A.; Linker R.A.; Chidgey A.; Dechend R.; Nguyen G.; Daumke O.; Muller D.N.; Wright M.D.; Binger K.J.
New role for the (pro)renin receptor in T cell development
Blood 126 (4): 504-507 (2015-07-23)



Dick A.; Graf L.; Olal D.; von der Malsburg A.; Gao S.; Kochs G.; Daumke O.
Role of nucleotide binding and GTPase domain dimerization in dynamin-like myxovirus resistance protein A for GTPase activation and antiviral activity
Journal of Biological Chemistry 290 (20): 12779-12792 (2015-05-15)



2014

Schuetz A.; Murakawa Y.; Rosenbaum E.; Landthaler M.; Heinemann U.
Roquin binding to target mRNAs involves a winged helix-turn-helix motif
Nature Communications 5: 5701 (2014-12-11)



Olal D.; Dick A.; Woods V.L.; Liu T.; Li S.; Devignot S.; Weber F.; Saphire E.O.; Daumke O.
Structural insights into RNA encapsidation and helical assembly of the Toscana virus nucleoprotein
Nucleic Acids Research 42 (9): 6025-6037 (2014-05-14)



Shah C.; Hegde B.G.; Moren B.; Behrmann E.; Mielke T.; Moenke G.; Spahn C.M.; Lundmark R.; Daumke O.; Langen R.
Structural insights into membrane interaction and caveolar targeting of dynamin-like EHD2
Structure 22 (3): 409-420 (2014-03-04)



Daumke O.; Roux A.; Haucke V.
BAR domain scaffolds in dynamin-mediated membrane fission
Cell 156 (5): 882-892 (2014-02-27)



2013

Wenger J.; Klinglmayr E.; Froehlich C.; Eibl C.; Gimeno A.; Hessenberger M.; Puehringer S.; Daumke O.; Goettig P.
Functional mapping of human dynamin-1-like GTPase domain based on X-ray structure analyses
PLoS ONE 8 (8): e71835 (2013-08-19)



Froehlich C.; Grabiger S.; Schwefel D.; Faelber K.; Rosenbaum E.; Mears J.; Rocks O.; Daumke O.
Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein
EMBO Journal 32 (9): 1280-1292 (2013-05-02)



Schwefel D.; Arasu B.S.; Marino S.F.; Lamprecht B.; Koechert K.; Rosenbaum E.; Eichhorst J.; Wiesner B.; Behlke J.; Rocks O.; Mathas S.; Daumke O.
Structural insights into the mechanism of GTPase activation in the GIMAP family
Structure 21 (4): 550-559 (2013-04-02)



Faelber K.; Gao S.; Held M.; Posor Y.; Haucke V.; Noe F.; Daumke O.
Oligomerization of dynamin superfamily proteins in health and disease
Progress in Molecular Biology and Translational Science 117: 411-443 (2013)



2012

Faelber K.; Held M.; Gao S.; Posor Y.; Haucke V.; Noe F.; Daumke O.
Structural insights into dynamin-mediated membrane fission
Structure 20 (10): 1621-1628 (2012-10-10)



Marg A.; Schoewel V.; Timmel T.; Schulze A.; Shah C.; Daumke O.; Spuler S.
Sarcolemmal repair is a slow process and includes EHD2
Traffic 13 (9): 1286-1294 (2012-09)



Brand J.; Smith E.S.J.; Schwefel D.; Lapatsina L.; Poole K.; Omerbasic D.; Kozlenkov A.; Behlke J.; Lewin G.R.; Daumke O.
A stomatin dimer modulates the activity of acid-sensing ion channels
EMBO Journal 31 (17): 3635-3646 (2012-08-29)



Lapatsina L.; Brand J.; Poole K.; Daumke O.; Lewin G.R.
Stomatin-domain proteins
European Journal of Cell Biology 91 (4): 240-245 (2012-04)



Moren B.; Shah C.; Howes M.T.; Schieber N.L.; McMahon H.T.; Parton R.G.; Daumke O.; Lundmark R.
EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization
Molecular Biology of the Cell 23 (7): 1316-1329 (2012-02-09)



2011

Gao S.; von der Malsburg A.; Dick A.; Faelber K.; Schroeder G.F.; Haller O.; Kochs G.; Daumke O.
Structure of myxovirus resistance protein A reveals intra- and intermolecular domain interactions required for the antiviral function
Immunity 35 (4): 514-525 (2011-10-28)



Faelber K.; Posor Y.; Gao S.; Held M.; Roske Y.; Schulze D.; Haucke V.; Noe F.; Daumke O.
Crystal structure of nucleotide-free dynamin
Nature 477 (7366): 556-560 (2011-09-29)



Licht A.; Bulut H.; Scheffel F.M.; Daumke O.; Wehmeier U.F.; Saenger W.; Schneider E.; Vahedi-Faridi A.
Crystal structures of the bacterial solute receptor AcbH displaying an exclusive substrate preference for beta-D-galactopyranose
Journal of Molecular Biology 406 (1): 92-105 (2011-02-11)



Daumke O.; Praefcke G.J.
Structural insights into membrane fusion at the endoplasmic reticulum
Proceedings of the National Academy of Sciences of the United States of America 108 (6): 2175-2176 (2011-02-08)



Schwefel D.; Daumke O.
GTP-dependent scaffold formation in the GTPase of Immunity Associated Protein family
Small GTPases 2 (1): 27-30 (2011-01)



2010

Hee C.S.; Gao S.; Loll B.; Miller M.M.; Uchanska-Ziegler B.; Daumke O.; Ziegler A.
Structure of a classical MHC class I molecule that binds "non-classical" ligands
PLoS Biology 8 (12): e1000557 (2010-12-07)



Schwefel D.; Froehlich C.; Eichhorst J.; Wiesner B.; Behlke J.; Aravind L.; Daumke O.
Structural basis of oligomerization in septin-like GTPase of immunity-associated protein 2 (GIMAP2)
Proceedings of the National Academy of Sciences of the United States of America 107 (47): 20299-20304 (2010-11-23)



Haller O.; Gao S.; von der Malsburg A.; Daumke O.; Kochs G.
Dynamin-like MxA GTPase: Structural insights into oligomerization and implications for antiviral activity
Journal of Biological Chemistry 285 (37): 28419-28424 (2010-09-10)



Daumke O.; Gao S.; von der Malsburg A.; Haller O.; Kochs G.
Structure of the MxA stalk elucidates the assembly of ring-like units of an antiviral module
Small GTPases 1 (1): 62-64 (2010-07)



Schwefel D.; Froehlich C.; Daumke O.
Purification, crystallization and preliminary X-ray analysis of human GIMAP2
Acta Crystallographica Section F 66 (6): 725-729 (2010-06-01)



Gao S.; von der Malsburg A.; Paeschke S.; Behlke J.; Haller O.; Kochs G.; Daumke O.
Structural basis of oligomerization in the stalk region of dynamin-like MxA
Nature 465 (7297): 502-506 (2010-05-27)



2009

Selbach M.; Paul F.E.; Brandt S.; Guye P.; Daumke O.; Backert S.; Dehio C.; Mann M.
Host cell interactome of tyrosine-phosphorylated bacterial proteins
Cell Host & Microbe 5 (4): 397-403 (2009-04-23)



Hee C.S.; Gao S.; Miller M.M.; Goto R.M.; Ziegler A.; Daumke O.; Uchanska-Ziegler B.
Expression, purification and preliminary X-ray crystallographic analysis of the chicken MHC class I molecule YF1*7.1
Acta Crystallographica Section F 65 (Pt 4): 422-425 (2009-04-01)



2007

Daumke O.; Lundmark R.; Vallis Y.; Martens S.; Butler P.J.G.; McMahon H.T.
Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling
Nature 449 (7164): 923-927 (2007-10-03)



Henne W.M.; Kent H.M.; Ford M.G.J.; Hegde B.G.; Daumke O.; Butler P.J.G.; Mittal R.; Langen R.; Evans P.R.; McMahon H.T.
Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature
Structure 15 (7): 839-52 (2007-07)



Chakrabarti P.P.; Daumke O.; Suveyzdis Y.; Koetting C.; Gerwert K.; Wittinghofer A.
Insight into catalysis of a unique GTPase reaction by a combined biochemical and FTIR approach
Journal of Molecular Biology 367 (4): 983-95 (2007-04-06)