Human Gene Therapy 21 (9): 1039-1042 (2010-09)

Buening H.; Uckert W.; Cichutek K.; Hawkins R.E.; Abken H.

Do CARs need a driver's license? Adoptive cell therapy with chimeric antigen receptor-redirected T cells caused serious adverse events

Adoptive transfer of genetically retargeted T cells provides promise in the therapy of malignant diseases; two severe adverse events, however, due to "on-targeted" activation of modified T cells occurred in recent trials. We here discuss the challenge to balance targeted anti-tumor responses whilst avoiding destruction of healthy tissues and the need of continued and carefully designed pre-clinical and clinical evaluations.

Keywords: Adoptive Immunotherapy, Antigen Receptors, Clinical Trials, Lymphocyte Activation, Recombinant Proteins, T-Lymphocytes, Animals, Mice

Type: Editorial

PubMed: 20626322
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