Publikationen

Methods in Molecular Biology 1193: 117-126 (2014)

Kieback E.; Hilgenberg E.; Fillatreau S.

A method for the generation of TCR retrogenic mice

Description:
Retrogenic mice provide a unique system for rapidly analyzing the function of genes in the hematopoietic system. Here, we provide a detailed protocol for the production of retrogenic mice expressing genes coding for T cell receptor (TCR) for antigen. This technology should be easy to establish in any laboratory and should allow for a rapid progress in our understanding of the functional roles of TCR repertoires in immunity.

Keywords: Mice, Animals, Transfection, Transduction, Retrovirus, Retrogenic Mice, T Cell Receptor for Antigen (TCR)

Type: Article

PubMed: 25151002
Official URL: https://doi.org/10.1007/978-1-4939-1212-4_12
MDC Repository: https://edoc.mdc-berlin.de/14320/