Publications



2017

Rathjen T.; Yan X.; Kononenko N.L.; Ku M.C.; Song K.; Ferrarese L.; Tarallo V.; Puchkov D.; Kochlamazashvili G.; Brachs S.; Varela L.; Szigeti-Buck K.; Yi C.X.; Schriever S.C.; Tattikota S.G.; Carlo A.S.; Moroni M.; Siemens J.; Heuser A.; van der Weyden L.; Birkenfeld A.L.; Niendorf T.; Poulet J.F.A.; Horvath T.L.; Tschoep M.H.; Heinig M.; Trajkovski M.; Haucke V.; Poy M.N.
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1
Nature Neuroscience 20 (8): 1096-1103 (2017-08)



Wang D.; Opperhuizen A.L.; Reznick J.; Turner N.; Su Y.; Cooney G.J.; Kalsbeek A.
Effects of feeding time on daily rhythms of neuropeptide and clock gene expression in the rat hypothalamus
Brain Research : (2017-07-12)



Moshourab R.; Begay V.; Wetzel C.; Walcher J.; Middleton S.; Gross M.; Lewin G.R.
Congenital deafness is associated with specific somatosensory deficits in adolescents
Scientific Reports 7 (1): 4251 (2017-06-26)



Schwaller F.; Kanellopoulos A.H.; Fitzgerald M.
The developmental emergence of differential brainstem serotonergic control of the sensory spinal cord
Scientific Reports 7 (1): 2215 (2017-05-22)



Park T.J.; Reznick J.; Peterson B.L.; Blass G.; Omerbasic D.; Bennett N.C.; Kuich P.H.J.L.; Zasada C.; Browe B.M.; Hamann W.; Applegate D.T.; Radke M.H.; Kosten T.; Lutermann H.; Gavaghan V.; Eigenbrod O.; Begay V.; Amoroso V. G.; Govind V.; Minshall R.D.; Smith E.S.J.; Larson J.; Gotthardt M.; Kempa S.; Lewin G.R.
Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat
Science 356 (6335): 307-311 (2017-04-21)



Bernal Sierra Y.A.; Haseleu J.; Kozlenkov A.; Begay V.; Lewin G.R.
Genetic tracing of Cav3.2 T-type calcium channel expression in the peripheral nervous system
Frontiers in Molecular Neuroscience 10 (70): 70 (2017-03-15)



Cirovic B.; Schoenheit J.; Kowenz-Leutz E.; Ivanovska J.; Klement C.; Pronina N.; Begay V.; Leutz A.
C/EBP-induced transdifferentiation reveals granulocyte-macrophage precursor-like plasticity of B cells
Stem Cell Reports 14 (8): 346-359 (2017-02-14)



Wetzel C.; Pifferi S.; Picci C.; Goek C.; Hoffmann D.; Bali K.K.; Lampe A.; Lapatsina L.; Fleischer R.; Smith E.S.J.; Begay V.; Moroni M.; Estebanez L.; Kuehnemund J.; Walcher J.; Specker E.; Neuenschwander M.; von Kries J.P.; Haucke V.; Kuner R.; Poulet J.F.A.; Schmoranzer J.; Poole K.; Lewin G.R.
Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity
Nature Neuroscience 20 (2): 209-218 (2017-02)



Bozek K.; Khrameeva E.E.; Reznick J.; Omerbasic D.; Bennett N.C.; Lewin G.R.; Azpurua J.; Gorbunova V.; Seluanov A.; Regnard P.; Wanert F.; Marchal J.; Pifferi F.; Aujard F.; Liu Z.; Shi P.; Paeaebo S.; Schroeder F.; Willmitzer L.; Giavalisco P.; Khaitovich P.
Lipidome determinants of maximal lifespan in mammals
Scientific Reports 7: 5 (2017-01-31)



Servin-Vences M.R.; Moroni M.; Lewin G.R.; Poole K.
Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes
eLife 6: e21074 (2017-01-30)



2016

Venteo S.; Laffray S.; Wetzel C.; Rivat C.; Scamps F.; Mechaly I.; Bauchet L.; Raoul C.; Bourinet E.; Lewin G.R.; Carroll P.; Pattyn A.
Fxyd2 regulates A{delta}- and C-fiber mechanosensitivity and is required for the maintenance of neuropathic pain
Scientific Reports 6: 36407 (2016-11-02)



Omerbasic D.; Smith E.S.J.; Moroni M.; Homfeld J.; Eigenbrod O.; Bennett N.C.; Reznick J.; Faulkes C.G.; Selbach M.; Lewin G.R.
Hypofunctional TrkA accounts for the absence of pain sensitization in the African naked mole-rat
Cell Reports 17 (3): 748-758 (2016-10-11)



Moshourab R.; Frenzel H.; Lechner S.; Haseleu J.; Begay V.; Omerbasic D.; Lewin G.R.
Measurement of vibration detection threshold and tactile spatial acuity in human subjects
Journal of Visualized Experiments (115): e52966 (2016-09-01)



Moshourab R.; Palada V.; Grunwald S.; Grieben U.; Lewin G.R.; Spuler S.
A molecular signature of myalgia in myotonic dystrophy 2
EBioMedicine 7: 205-211 (2016-05)



Grandin M.; Meier M.; Delcros J.G.; Nikodemus D.; Reuten R.; Patel T.R.; Goldschneider D.; Orriss G.; Krahn N.; Boussouar A.; Abes R.; Dean Y.; Neves D.; Bernet A.; Depil S.; Schneiders F.; Poole K.; Dante R.; Koch M.; Mehlen P.; Stetefeld J.
Structural decoding of the netrin-1/UNC5 interaction and its therapeutical implications in cancers
Cancer Cell 29 (2): 173-185 (2016-02-08)



2015

Dezhdar T.; Moshourab R.A.; Fruend I.; Lewin G.R.; Schmuker M.
A probabilistic model for estimating the depth and threshold temperature of C-fiber nociceptors
Scientific Reports 5: 17670 (2015-12-07)



Omerbasic D.; Schuhmacher L.N.; Bernal Sierra Y.A.; Smith E.S.J.; Lewin G.R.
ASICs and mammalian mechanoreceptor function
Neuropharmacology 94: 80-86 (2015-07)



Frank J.A.; Moroni M.; Moshourab R.; Sumser M.; Lewin G.R.; Trauner D.
Photoswitchable fatty acids enable optical control of TRPV1
Nature Communications 6: 7118 (2015-05-21)



Hanack C.; Moroni M.; Lima W.C.; Wende H.; Kirchner M.; Adelfinger L.; Schrenk-Siemens K.; Tappe-Theodor A.; Wetzel C.; Kuich P.H.; Gassmann M.; Roggenkamp D.; Bettler B.; Lewin G.R.; Selbach M.; Siemens J.
GABA blocks pathological but not acute TRPV1 pain signals
Cell 160 (4): 759-770 (2015-02-12)



Poole K.; Moroni M.; Lewin G.R.
Sensory mechanotransduction at membrane-matrix interfaces
Pfluegers Archiv European Journal of Physiology 467 (1): 121-132 (2015-01-15)



Schrenk-Siemens K.; Wende H.; Prato V.; Song K.; Rostock C.; Loewer A.; Utikal J.; Lewin G.R.; Lechner S.G.; Siemens J.
PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors
Nature Neuroscience 18 (1): 10-16 (2015-01)



2014

Ranade S.S.; Woo S.H.; Dubin A.E.; Moshourab R.A.; Wetzel C.; Petrus M.; Mathur J.; Begay V.; Coste B.; Mainquist J.; Wilson A.J.; Francisco A.G.; Reddy K.; Qiu Z.; Wood J.N.; Lewin G.R.; Patapoutian A.
Piezo2 is the major transducer of mechanical forces for touch sensation in mice
Nature 516 (7529): 121-125 (2014-12-04)



Milenkovic N.; Zhao W.J.; Walcher J.; Albert T.; Siemens J.; Lewin G.R.; Poulet J.F.A.
A somatosensory circuit for cooling perception in mice
Nature Neuroscience 17 (11): 1560-1566 (2014-11)



Ceko M.; Milenkovic N.; Le Coutre P.; Westermann J.; Lewin G.R.
Inhibition of c-Kit signaling is associated with reduced heat and cold pain sensitivity in humans
Pain 155 (7): 1222-1228 (2014-07)



Poole K.; Herget R.; Lapatsina L.; Ngo H.D.; Lewin G.R.
Tuning piezo ion channels to detect molecular-scale movements relevant for fine touch
Nature Communications 5: 3520 (2014-03-24)



Kozlenkov A.; Lapatsina L.; Lewin G.R.; Smith E.S.J.
Subunit-specific inhibition of acid sensing ion channels by stomatin-like protein 1
Journal of Physiology 592 (Pt 4): 557-569 (2014-02-15)



Sheean M.E.; McShane E.; Cheret C.; Walcher J.; Mueller T.; Wulf-Goldenberg A.; Hoelper S.; Garratt A.N.; Krueger M.; Rajewsky K.; Meijer D.; Birchmeier W.; Lewin G.R.; Selbach M.; Birchmeier C.
Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination
Genes & Development 28 (3): 290-303 (2014-02-01)



Lewin G.R.; Nykjaer A.
Pro-neurotrophins, sortilin, and nociception
European Journal of Neuroscience 39 (3): 363-374 (2014-02)



Haseleu J.; Omerbasic D.; Frenzel H.; Gross M.; Lewin G.R.
Water-induced finger wrinkles do not affect touch acuity or dexterity in handling wet objects
PLoS ONE 9 (1): e84949 (2014-01-08)



Lewin G.R.; Lechner S.G.; Smith E.S.J.
Nerve growth factor and nociception: from experimental embryology to new analgesic therapy
Handbook of Experimental Pharmacology 220: 251-282 (2014)




Neurotrophic factors
Handbook of Experimental Pharmacology 220: (2014)



2013

Moshourab R.A.; Wetzel C.; Martinez-Salgado C.; Lewin G.R.
Stomatin-domain protein interactions with acid sensing ion channels modulate nociceptor mechanosensitivity
Journal of Physiology 591 (Pt 22): 5555-5574 (2013-11-15)



Lewin G.R.
Natural selection and pain meet at a sodium channel
Science 342 (6157): 428-429 (2013-10-25)



Lechner S.G.; Lewin G.R.
Hairy sensation
Physiology 28 (3): 142-150 (2013-05)



2012

Wende H.; Lechner S.G.; Birchmeier C.
The transcription factor c-Maf in sensory neuron development
Transcription 3 (6): 285-289 (2012-11)



Brand J.; Smith E.S.J.; Schwefel D.; Lapatsina L.; Poole K.; Omerbasic D.; Kozlenkov A.; Behlke J.; Lewin G.R.; Daumke O.
A stomatin dimer modulates the activity of acid-sensing ion channels
EMBO Journal 31 (17): 3635-3646 (2012-08-29)



Smith E.S.J.; Purfuerst B.; Grigoryan T.; Park T.J.; Bennett N.C.; Lewin G.R.
Specific paucity of unmyelinated C-fibers in cutaneous peripheral nerves of the African naked-mole rat: comparative analysis using six species of bathyergidae
Journal of Comparative Neurology 520 (12): 2785-2803 (2012-08-15)



Stock K.; Kumar J.; Synowitz M.; Petrosino S.; Imperatore R.; Smith E.S.J.; Wend P.; Purfuerst B.; Nuber U.A.; Gurok U.; Matyash V.; Waelzlein J.H.; Chirasani S.R.; Dittmar G.; Cravatt B.F.; Momma S.; Lewin G.R.; Ligresti A.; De Petrocellis L.; Cristino L.; Di Marzo V.; Kettenmann H.; Glass R.
Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1
Nature Medicine 18 (8): 1232-1238 (2012-08)



Lapatsina L.; Jira J.A.; Smith E.S.J.; Poole K.; Kozlenkov A.; Bilbao D.; Lewin G.R.; Heppenstall P.A.
Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons
Open Biology 2 (6): 120096 (2012-06-27)



Frenzel H.; Bohlender J.; Pinsker K.; Wohlleben B.; Tank J.; Lechner S.G.; Schiska D.; Jaijo T.; Rueschendorf F.; Saar K.; Jordan J.; Millan J.M.; Gross M.; Lewin G.R.
A genetic basis for mechanosensory traits in humans
PLoS Biology 10 (5): e1001318 (2012-05-01)



Lapatsina L.; Brand J.; Poole K.; Daumke O.; Lewin G.R.
Stomatin-domain proteins
European Journal of Cell Biology 91 (4): 240-245 (2012-04)



Wende H.; Lechner S.G.; Cheret C.; Bourane S.; Kolanczyk M.E.; Pattyn A.; Reuter K.; Munier F.L.; Carroll P.; Lewin G.R.; Birchmeier C.
The transcription factor c-Maf controls touch receptor development and function
Science 335 (6074): 1373-1376 (2012-03-16)



Luo C.; Gangadharan V.; Bali K.K.; Xie R.G.; Agarwal N.; Kurejova M.; Tappe-Theodor A.; Tegeder I.; Feil S.; Lewin G.; Polgar E.; Todd A.J.; Schlossmann J.; Hofmann F.; Liu D.L.; Hu S.J.; Feil R.; Kuner T.; Kuner R.
Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity
PLoS Biology 10 (3): e1001283 (2012-03-13)



Tappe-Theodor A.; Constantin C.E.; Tegeder I.; Lechner S.G.; Langeslag M.; Lepcynzsky P.; Wirotanseng R.I.; Kurejova M.; Agarwal N.; Nagy G.; Todd A.; Wettschureck N.; Offermanns S.; Kress M.; Lewin G.R.; Kuner R.
G{alpha}(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization
Pain 153 (1): 184-196 (2012-01)



Heidenreich M.; Lechner S.G.; Vardanyan V.; Wetzel C.; Cremers C.W.; De Leenheer E.M.; Aranguez G.; Moreno-Pelayo M.A.; Jentsch T.J.; Lewin G.R.
KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man
Nature Neuroscience 15 (1): 138-145 (2012)



2011

Smith E.S.; Omerbasic D.; Lechner S.G.; Anirudhan G.; Lapatsina L.; Lewin G.R.
The molecular basis of acid insensitivity in the African naked mole-rat
Science 334 (6062): 1557-1560 (2011-12-16)



Chiang L.Y.; Poole K.; Oliveira B.E.; Duarte N.; Bernal Sierra Y.A.; Bruckner-Tuderman L.; Koch M.; Hu J.; Lewin G.R.
Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons
Nature Neuroscience 14 (8): 993-1000 (2011-07-03)



Wang R.; Lewin G.R.
The Cav3.2 T-type calcium channel regulates temporal coding in mouse mechanoreceptors
Journal of Physiology 589 (9): 2229-2243 (2011-05-01)



Lechner S.G.; Siemens J.
Sensory transduction, the gateway to perception: mechanisms and pathology
EMBO Reports 12 (4): 292-295 (2011-04-01)



Gangadharan V.; Wang R.; Ulzhoefer B.; Luo C.; Bardoni R.; Bali K.K.; Agarwal N.; Tegeder I.; Hildebrandt U.; Nagy G.G.; Todd A.J.; Ghirri A.; Haeussler A.; Sprengel R.; Seeburg P.H.; Macdermott A.B.; Lewin G.R.; Kuner R.
Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice
Journal of Clinical Investigation 121 (4): 1608-1623 (2011-04-01)



Lechner S.G.; Markworth S.; Poole K.; Smith E.S.J.; Lapatsina L.; Frahm S.; May M.; Pischke S.; Suzuki M.; Ibanez-Tallon I.; Luft F.C.; Jordan J.; Lewin G.R.
The molecular and cellular identity of peripheral osmoreceptors
Neuron 69 (2): 332-344 (2011-01-27)



Vaegter C.B.; Jansen P.; Fjorback A.W.; Glerup S.; Skeldal S.; Kjolby M.; Richner M.; Erdmann B.; Nyengaard J.R.; Tessarollo L.; Lewin G.R.; Willnow T.E.; Chao M.V.; Nykjaer A.
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling
Nature Neuroscience 14 (1): 54-61 (2011-01)



2010

Brand A.; Smith E.S.; Lewin G.R.; Park T.J.
Functional neurokinin and NMDA receptor activity in an animal naturally lacking Substance P: the naked mole-rat
PLoS ONE 5 (12): e15162 (2010-12-21)



Bishop T.; Marchand F.; Young A.R.; Lewin G.R.; McMahon S.B.
Ultraviolet-B-induced mechanical hyperalgesia: A role for peripheral sensitisation
Pain 150 (1): 141-152 (2010-07)



Smith E.S.; Blass G.R.; Lewin G.R.; Park T.J.
Absence of histamine-induced itch in the African naked mole-rat and "rescue" by Substance P
Molecular Pain 6 (1): 29 (2010-05-24)



Stuerzebecher A.S.; Hu J.; Smith E.S.J.; Frahm S.; Santos-Torres J.; Kampfrath B.; Auer S.; Lewin G.R.; Ibanez-Tallon I.
An in vivo tethered toxin approach for the cell-autonomous inactivation of voltage-gated sodium channel currents in nociceptors
Journal of Physiology 588 (Pt 10): 1695-1707 (2010-05-15)



Hu J.; Chiang L.Y.; Koch M.; Lewin G.R.
Evidence for a protein tether involved in somatic touch
EMBO Journal 29 (4): 855-867 (2010-02-17)



2009

Smith E.S.; Lewin G.R.
Nociceptors: a phylogenetic view
Journal of Comparative Physiology A 195 (12): 1089-1106 (2009-12)



Lechner S.G.; Lewin G.R.
Peripheral sensitisation of nociceptors via G-protein dependent potentiation of mechanotransduction currents
Journal of Physiology 587 (Pt 14): 3493-3503 (2009-07-15)



Lechner S.G.; Frenzel H.; Wang R.; Lewin G.R.
Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development
EMBO Journal 28 (10): 1479-1491 (2009-05-20)



2008

Milenkovic N.; Wetzel C.; Moshourab R.; Lewin G.R.
Speed and temperature dependence of mechanotransduction in in afferent fibers recorded from the mouse saphenous nerve
Journal of Neurophysiology 100 (5): 2771-2783 (2008-11-01)



Lewin G.R.
Stretching it for pain
Pain 137 (1): 3-4 (2008-07)



Smith E.S.J.; Momin A.
Persistent pain: the contribution of NaV1.9
Journal of Physiology 586 (9): 2249-2250 (2008-05)



Ludwig T.; Kirmse R.; Poole K.; Schwarz U.S.
Probing cellular microenvironments and tissue remodeling by atomic force microscopy
Pfluegers Archiv European Journal of Physiology 456 (1): 29-49 (2008-04)



Park T.J.; Lu Y.; Juettner R.; Smith E.S.J.; Hu J.; Brand A.; Wetzel C.; Milenkovic N.; Erdmann B.; Heppenstall P.A.; Laurito C.E.; Wilson S.P.; Lewin G.R.
Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber)
PLoS Biology 6 (1): e13 (2008-01-29)



2007

Milenkovic N.; Frahm C.; Gassmann M.; Griffel C.; Erdmann B.; Birchmeier C.; Lewin G.R.; Garratt A.N.
Nociceptive tuning by stem cell factor/c-Kit signaling
Neuron 56 (5): 893-906 (2007-12-06)



Martinez-Salgado C.; Benckendorff A.G.; Chiang L.Y.; Wang R.; Milenkovic N.; Wetzel C.; Hu J.; Stucky C.L.; Parra M.G.; Mohandas N.; Lewin G.R.
Stomatin and sensory neuron mechanotransduction
Journal of Neurophysiology 98 (6): 3802-3808 (2007-12-01)



Jansen P.; Giehl K.; Nyengaard J.R.; Teng K.; Lioubinski O.; Sjoegaard S.S.; Breiderhoff T.; Gotthardt M.; Lin F.; Eilers A.; Petersen C.M.; Lewin G.R.; Hempstead B.L.; Willnow T.E.; Nykjaer A.
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury
Nature Neuroscience 10 (11): 1449-1457 (2007-11)



Wetzel C.; Hu J.; Riethmacher D.; Benckendorff A.; Harder L.; Eilers A.; Moshourab R.; Kozlenkov A.; Labuz D.; Caspani O.; Erdmann B.; Machelska H.; Heppenstall P.A.; Lewin G.R.
A stomatin-domain protein essential for touch sensation in the mouse
Nature 445 (7124): 206-209 (2007-01-11)



2006

Hu J.; Lewin G.R.
Mechanosensitive currents in the neurites of cultured mouse sensory neurones
Journal of Physiology 577 (Pt.3): 815-828 (2006-12-15)



Heppenstall P.A.; Lewin G.R.
A role for T-type Ca2+ channels in mechanosensation
Cell Calcium 40 (2): 165-174 (2006-08)



Boensch R.; Lewin G.R.
Finding sensory neuron mechanotransduction components
: 379-414 (2006)



Hu J.; Milenkovic N.; Lewin G.R.
The high threshold mechanotransducer: A status report
Pain 120 (1-2): 3-7 (2006-01)



2005

McIlwrath S.L.; Hu J.; Anirudhan G.; Shin J.B.; Lewin G.R.
The sensory mechanotransduction ion channel ASIC2 (acid sensitive ion channel 2) is regulated by neurotrophin availability
Neuroscience 131 (2): 499-511 (2005-01-01)



2004

Hartmann B.; Ahmadi S.; Heppenstall P.A.; Lewin G.R.; Schott C.; Borchardt T.; Seeburg P.H.; Zeilhofer H.U.; Sprengel R.; Kuner R.
The AMPA receptor subunits GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory pain
Neuron 44 (4): 637-650 (2004-11-18)



Dubreuil A.S.; Boukhaddaoui H.; Desmadryl G.; Martinez-Salgado C.; Moshourab R.; Lewin G.R.; Carroll P.; Valmier J.; Scamps F.
Role of T-type calcium current in identified D-hair mechanoreceptor neurons studied in vitro
Journal of Neuroscience 24 (39): 8480-8484 (2004-09-29)



Lewin G.R.; Lu Y.; Park T.J.
A plethora of painful molecules
Current Opinion in Neurobiology 14 (4): 443-449 (2004-08-01)



Page A.J.; Brierley S.M.; Martin C.M.; Martinez-Salgado C.; Wemmie J.A.; Brennan T.J.; Symonds E.; Omari T.; Lewin G.R.; Welsh M.J.; Blackshaw L.A.
The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function
Gastroenterology 127 (6): 1739-1747 (2004-01-01)



Lewin G.R.; Moshourab R.
Mechanosensation and pain
Journal of Neurobiology 61: 30-44 (2004-01-01)



2003

Shin J.B.; Martinez-Salgado C.; Heppenstall P.A.; Lewin G.R.
A T-type calcium channel required for normal function of a mammalian mechanoreceptor
Nature Neuroscience 6 (7): 724-730 (2003-07)



Lucius H.; Friedrichson T.; Kurzchalia T.V.; Lewin G.R.
Identification of caveolae-like structures on the surface of intact cells using scanning force microscopy
Journal of Membrane Biology 194 (2): 97-108 (2003-06)



Winter J.; Lehmann T.; Suckow V.; Kijas Z.; Kulozik A.; Kalscheuer V.; Hamel B.; Devriendt K.; Opitz J.; Lenzner S.; Ropers H.H.; Schweiger S.
Duplication of the MID1 first exon in a patient with Opitz G/BBB syndrome
Human Genetics 112 (3): 249-254 (2003-03)



2002

Schmidt H.; Werner M.; Heppenstall P.A.; Henning M.; More M.I.; Kuehbandner S.; Lewin G.R.; Hofmann F.; Feil R.; Rathjen F.G.
cGMP-mediated signaling via cGKI{alpha}s required for the guidance and connectivity of sensory axons
Journal of Cell Biology 159 (3): 489-498 (2002-11-11)



Stucky C.L.; Rossi J.; Airaksinen M.S.; Lewin G.R.
GFR {alpha}2/neurturin signalling regulates noxious heat transduction in isolectin B4- binding mouse sensory neurons
Journal of Physiology 545 (1): 43-50 (2002-11)



Stucky C.L.; Shin J.B.; Lewin G.R.
Neurotrophin-4: a survival factor for adult sensory neurons
Current Biology 12 (16): 1401-1404 (2002-08-20)



Mueller T.; Brohmann H.; Pierani A.; Heppenstall P.A.; Lewin G.R.; Jessell T.M.; Birchmeier C.
The homeodomain factor Lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord
Neuron 34 (4): 551-562 (2002-05-16)



Postigo A.; Calella A.M.; Fritzsch B.; Knipper M.; Katz D.; Eilers A.; Schimmang T.; Lewin G.R.; Klein R.; Minichiello L.
Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons
Genes & Development 16 (5): 633-645 (2002-01-01)



2001

Price M.P.; McIlwrath S.L.; Xie J.H.; Cheng C.; Qiao J.; Tarr D.E.; Sluka K.A.; Brennan T.J.; Lewin G.R.; Welsh M.J.
The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice
Neuron 32 (6): 1071-1083 (2001-12-20)



Heppenstall P.A.; Lewin G.R.
BDNF but not NT-4 is required for normal flexion reflex plasticity and function
Proceedings of the National Academy of Sciences of the United States of America 98 (14): 8107-8112 (2001-07-03)



Roosen A.; Schober A.; Strelau J.; Boettner M.; Faulhaber J.; Bendner G.; McIlwrath S.L.; Seller H.; Ehmke H.; Lewin G.R.; Unsicker K.
Lack of neurotrophin-4 causes selective structural and chemical deficits in sympathetic ganglia and their preganglionic innervation
Journal of Neuroscience 21 (9): 3073-3084 (2001-05-01)



Hamilton S.G.; McMahon S.B.; Lewin G.R.
Selective activation of nociceptors by P2X receptor agonists in normal and inflamed rat skin
Journal of Physiology 534 (2): 437-445 (2001-01-01)



2000

Price M.P.; Lewin G.R.; McIlwrath S.L.; Cheng C.; Xie J.H.; Heppenstall P.A.; Stucky C.L.; Mannsfeldt A.G.; Brennan T.J.; Drummond H.A.; Qiao J.; Benson C.J.; Tarr D.E.; Hrstka R.F.; Yang B.L.; Williamson R.A.; Welsh M.J.
The mammalian sodium channel BNC1 is required for normal touch sensation
Nature 407 (6807): 1007-1011 (2000-10-26)



Heppenstall P.A.; Lewin G.R.
Neurotrophins, nociceptors and pain
Current Opinion in Anaesthesiology 13 (5): 573-576 (2000-10)



Pesquero J.B.; Araujo R.C.; Heppenstall P.A.; Stucky C.L.; Silva J.A.; Walther T.; Oliveira S.M.; Pesquero J.L.; Paiva A.C.M.; Calixto J.B.; Lewin G.R.; Bader M.
Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors
Proceedings of the National Academy of Sciences of the United States of America 97 (14): 8140-8145 (2000-07-05)



1999

Lommatzsch M.; Braun A.; Mannsfeldt A.; Botchkarev V.A.; Botchkareva N.V.; Paus R.; Fischer A.; Lewin G.R.; Renz H.
Abundant production of brain-derived neurotrophic factor by adult visceral epithelia - Implications for paracrine and target-derived neurotrophic functions
American Journal of Pathology 155: 1183-1193 (1999-10-01)



Braun A.; Lommatzsch M.; Mannsfeldt A.; Neuhaus-Steinmetz U.; Fischer A.; Schnoy N.; Lewin G.R.; Renz H.
Cellular sources of enhanced brain-derived neurotrophic factor production in a mouse model of allergic inflammation
American Journal of Respiratory Cell and Molecular Biology 21: 537-546 (1999-10-01)



Stucky C.L.; Lewin G.R.
Isolectin B4-positive and -negative nociceptors are functionally distinct
Journal of Neuroscience 19 (15): 6497-6505 (1999-08-01)



Mannsfeldt A.G.; Carroll P.; Stucky C.L.; Lewin G.R.
Stomatin, a MEC-2 like protein, is expressed by mammalian sensory neurons
Molecular and Cellular Neuroscience 13 (6): 391-404 (1999-06-01)



Braun A.; Lommatzsch M.; Lewin G.R.; Virchow J.C.; Renz H.
Neurotrophins: a link between airway inflammation and airway smooth muscle contractility in asthma?
International Archives of Allergy and Immunology 118 (2-4): 163-165 (1999-02)



Belyantseva I.A.; Lewin G.R.
Stability and plasticity of primary afferent projections following nerve regeneration and central degeneration
European Journal of Neuroscience 11: 457-468 (1999-02-01)



Botchkarev V.A.; Botchkareva N.V.; Welker P.; Metz M.; Lewin G.R.; Subramaniam A.; Bulfone-Paus S.; Hagen E.; Braun A.; Lommatzsch M.; Renz H.; Paus R.
A new role for neurotrophins: involvement of brain-derived neurotrophic factor and neurotrophin-4 in hair cycle control
FASEB Journal 13: 395-410 (1999-02-01)



1998

Botchkarev V.A.; Botchkareva N.V.; Lommatzsch M.; Peters E.M.J.; Lewin G.R.; Subramaniam A.; Braun A.; Renz H.; Paus R.
BDNF overexpression induces differential increases among subsets of sympathetic innervation in murine back skin
European Journal of Neuroscience 10: 3276-3283 (1998-10-01)



Schober A.; Wolf N.; Huber K.; Hertel R.; Krieglstein K.; Minichiello L.; Kahane N.; Widenfalk J.; Kalcheim C.; Olson L.; Klein R.; Lewin G.R.; Unsicker K.
TrkB and neurotrophin-4 are important for development and maintenance of sympathetic preganglionic neurons innervating the adrenal medulla
Journal of Neuroscience 18 (18): 7272-7284 (1998-09-15)



Botchkarev V.A.; Welker P.; Albers K.M.; Botchkareva N.V.; Metz M.; Lewin G.R.; Bulfone-Paus S.; Peters E.M.; Lindner G.; Paus R.
A new role for neurotrophin-3: Involvement in the regulation of hair follicle regression (catagen)
American Journal of Pathology 153: 785-799 (1998-09-01)



Minichiello L.; Casagranda F.; Tatche R.S.; Stucky C.L.; Postigo A.; Lewin G.R.; Davies A.M.; Klein R.
Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses
Neuron 21: 335-345 (1998-08-01)



Carroll P.; Lewin G.R.; Koltzenburg M.; Toyka K.V.; Thoenen H.
A role for BDNF in mechanosensation
Nature Neuroscience 1: 42-46 (1998-05-01)



Botchkarev V.A.; Botchkareva N.V.; Albers K.M.; van der Veen C.; Lewin G.R.; Paus R.
Neurotrophin-3 involvement in the regulation of hair follicle morphogenesis
Journal of Investigative Dermatology 111: 279-285 (1998-01-01)



1997

Riethmacher D.; Sonnenberg-Riethmacher E.; Brinkmann V.; Yamaai T.; Lewin G.R.; Birchmeier C.
Severe neuropathies in mice with targeted mutations in the ErbB3 receptor
Nature 389 (6652): 725-730 (1997-10-16)



Koltzenburg M.; Lewin G.R.
Der Einfluss von Neutrophinen auf den Phaenotyp sensorischer Neurone
Neuroforum 3, Heft 1: 27-31 (1997-01-01)



Koltzenburg M.; Lewin G.R.
Receptive properties of embryonic chick sensory neurons innervating skin
Journal of Neurophysiology 78: 2560-2568 (1997-01-01)



Koltzenburg M.; Stucky C.L.; Lewin G.R.
Receptive properties of mouse sensory neurons innervating hairy skin
Journal of Neurophysiology 78: 1841-1850 (1997-01-01)



Carter B.D.; Lewin G.R.
Neurotrophins live or let die: Does p75NTR decide
Neuron 18: 187-190 (1997-01-01)



1996

Lewin G.R.; Barde Y.A.
Physiology of the neurotrophins
Annual Review of Neuroscience 19: 289-317 (1996-03)



Airaksinen M.S.; Koltzenburg M.; Lewin G.R.; Masu Y.; Helbig C.; Wolf E.; Brem G.; Toyka K.V.; Thoenen H.; Meyer M.
Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation
Neuron 16: 287-295 (1996-01-01)



Ockel M.; Lewin G.R.; Barde Y.A.
In vivo effects of neurotrophin-3 during sensory neurogenesis
Development 122 (1): 301-307 (1996-01)



Lewin G.R.; Mendell L.M.
Maintenance of modality-specific connections in the spinal cord after neonatal nerve growth factor deprivation
European Journal of Neuroscience 8: 1677-1684 (1996-01-01)



Lewin G.R.
Neurotrophins and the specification of neuronal phenotype
Philosophical Transactions of the Royal Society of London Series B Biological Sciences 351: 405-411 (1996-01-01)



Ockel M.; von Schack D.; Schroepel A.; Dechant G.; Lewin G.R.; Barde Y.A.
Roles of neurotrophin-3 during early development of the peripheral nervous system
Philosophical Transactions of the Royal Society of London Series B Biological Sciences 351: 383-387 (1996-01-01)



1995

Lewin G.R.
Neurotropic Factors and Pain
Seminars in the Neurosciences 7: 227-232 (1995-01-01)



1994

Lewin G.R.; Rueff A.; Mendell L.M.
Peripheral and central mechanisms of NGF-induced hyperalgesia
European Journal of Neuroscience 6 (12): 1903-1912 (1994-12-01)



Lewin G.R.; Mckintosh E.; McMahon S.B.
NMDA receptors and activity-dependent tuning of the receptive fields of spinal cord neurons
Nature 369 (6480): 482-485 (1994-06-09)



Lewin G.R.; Mendell L.M.
Regulation of cutaneous C-fiber heat nociceptors by nerve growth factor in the developing rat
Journal of Neurophysiology 71 (3): 941-949 (1994-03-01)



Pierce J.P.; Lewin G.R.
An ultrastructural size principle
Neuroscience 58 (3): 441-446 (1994-02-01)



1993

Davis B.M.; Lewin G.R.; Mendell L.M.; Jones M.E.; Albers K.M.
Altered expression of nerve growth factor in the skin of transgenic mice leads to changes in response to mechanical stimuli
Neuroscience 56 (4): 789-792 (1993-10-01)



Lewin G.R.; Mendell L.M.
Nerve growth factor and nociception
Trends in Neurosciences 16: 353-359 (1993-09-01)



Lewin G.R.; McMahon S.B.
Muscle afferents innervating skin form somatotopically appropriate connections in the adult rat dorsal horn
European Journal of Neuroscience 5: 1083-1092 (1993-08-01)



Lewin G.R.; Ritter A.M.; Mendell L.M.
Nerve growth factor-induced hyperalgesia in the neonatal and adult rat
Journal of Neuroscience 13 (5): 2136-2148 (1993-05)



Ritter A.M.; Lewin G.R.; Mendell L.M.
Regulation of myelinated nociceptor function by nerve growth factor in neonatal and adult rats
Brain Research Bulletin 30: 245-249 (1993-01-01)



1992

Lewin G.R.; Ritter A.M.; Mendell L.M.
On the role of nerve growth factor in the development of myelinated nociceptors
Journal of Neuroscience 12 (5): 1896-1905 (1992-05)



Lewin G.R.; Winter J.; McMahon S.B.
Regulation of afferent connectivity in the adult spinal-cord by nerve growth factor
European Journal of Neuroscience 4: 700-707 (1992-01-01)



Lewin G.R.; Lisney S.J.W.; Mendell L.M.
Neonatal Anit-Ngf treatment reduces the Adelta-and c-fibre evoked vasodilator responses in rat skin: evidence that nociceptor afferents mediate antidromic vasodilatation
European Journal of Neuroscience 4: 1213-1218 (1992-01-01)