Proteomforschung und molekulare Mechanismen bei neurodegenerativen Erkrankungen



Prof. Dr. Erich Wanker



Millions of people worldwide suffer from neurodegenerative disorders. Most of these illnesses manifest themselves later in life. Therefore, correlated to the increase in life-expectancy the number of people affected with these diseases will grow.


The main objective of our work is to understand the pathomechanisms of late onset neurodegenerative disorders such as Huntington's, Parkinson's, Alzheimer's and Machado Joseph disease and to develop causal therapies for them. The disease causing proteins of these illnesses have been identified, but their functions in the unaffected organism are mostly unknown.

Since the identification of interacting proteins can give clues about the normal cellular function of proteins, we use high-throughput functional genomic approaches for establishing large protein-protein networks.

In vitro and in vivo functional assays are developed for high-throughput drug screenings.