Student's Publications:




Griemsmann S, Höft SP, Bedner P, Zhang J, von Staden E, Beinhauer A, Degen J, Dublin P, Cope DW, Richter N, Crunelli V, Jabs R, Willecke K, Theis M, Seifert G, Kettenmann H, Steinhäuser C.

Characterization of Panglial Gap Junction Networks in the Thalamus, Neocortex, and Hippocampus Reveals a Unique Population of Glial Cells.

Cereb Cortex. 2014 Jul 17. pii: bhu157. [Epub ahead of print]


Schleifenbaum J, Kassmann M, Szijártó IA, Hercule HC, Tano JY, Weinert S, Heidenreich M, Pathan AR, Anistan YM, Alenina N, Rusch NJ, Bader M, Jentsch TJ, Gollasch M.

Stretch-Activation of Angiotensin II Type 1a Receptors Contributes to the Myogenic Response of Mouse Mesenteric and Renal Arteries.

Circ Res. 2014 Jul 7;115(2):263-72.


Olias P*, Adam I*, Meyer A, Scharff C, Gruber AD.

Reference genes for quantitative gene expression studies in multiple avian species.

PLoS One. 2014 Jun 13;9(6):e99678. doi: 10.1371/journal.pone.0099678. eCollection 2014.

* equal contribution


Podufall J, Tian R, Knoche E, Puchkov D, Walter AM, Rosa S, Quentin C, Vukoja A, Jung N, Lampe A, Wichmann C, Böhme M, Depner H, Zhang YQ, Schmoranzer J, Sigrist SJ, Haucke V.

A Presynaptic Role for the Cytomatrix Protein GIT in Synaptic Vesicle Recycling.

Cell Rep. 2014 Jun 12;7(5):1417-25.


Mosienko V, Beis D, Pasqualetti M, Waider J, Matthes S, Qadri F, Bader M, Alenina N.

Life without brain serotonin: Reevaluation of serotonin function with mice deficient in brain serotonin synthesis.

Behav Brain Res. 2014 Jun 11.S0166-4328(14)00377-5.


Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, Rizzoli SO.

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.

Science.2014 May 30;344(6187):1023-8.


Adam I, Scharff C, Honarmand M.

Who is Who? Non-invasive Methods to Individually Sex and Mark Altricial Chicks.

J Vis Exp. 2014 May 24;(87).


Mosienko V, Matthes S, Hirth N, Beis D, Flinders M, Bader M, Hansson AC, Alenina N.

Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity.

Neuropharmacology. 2014 May 24;85C:73-80.


Kur E, Mecklenburg N, Cabrera RM, Willnow TE, Hammes A.

LRP2 mediates folate uptake in the developing neural tube.

J Cell Sci. 2014 May 15;127(Pt 10):2261-8.


Voss FK, Ullrich F, Münch J, Lazarow K, Lutter D, Mah N, Andrade-Navarro MA, von Kries JP, Stauber T, Jentsch TJ.

Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.

Science. 2014 May 9;344(6184):634-8.


Weiss M, Hultsch H, Adam I, Scharff C, Kipper S.

The use of network analysis to study complex animal communication systems: a study on nightingale song.

Proc Biol Sci. 2014 May 7;281(1785):20140460.


Schmitz T, Krabbe G, Weikert G, Scheuer T, Matheus F, Wang Y, Mueller S,Kettenmann H, Matyash V, Bührer C, Endesfelder S.

Minocycline protects the immature white matter against hyperoxia.

Exp Neurol. 2014 Apr;254:153-65.


Poole K, Herget R, Lapatsina L, Ngo HD, Lewin GR.

Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch.

Nat Commun. 2014 Mar 24;5:3520


Caglayan S, Takagi-Niidome S, Liao F, Carlo AS, Schmidt V, Burgert T, Kitago Y, Füchtbauer EM, Füchtbauer A, Holtzman DM, Takagi J, Willnow TE.

Lysosomal Sorting of Amyloid-β by the SORLA Receptor Is Impaired by a Familial Alzheimer's Disease Mutation.

Sci Transl Med. 2014 Feb 12;6(223):223ra20.


Sheean ME, McShane E, Cheret C, Walcher J, Müller T, Wulf-Goldenberg A. Hoelper S, Garratt AN, Krüger M, Rajewsky K, Meijer D, Birchmeier W, Lewin GR, Selbach M, Birchmeier C.

Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination.

Genes Dev. 2014 Feb 1;28(3):290-303.


Prigione A, Rohwer N, Hoffmann S, Mlody B, Drews K, Bukowiecki R, Blümlein K, Wanker EE, Ralser M, Cramer T,

Adjaye J. HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2.

Stem Cells.2014 Feb;32(2):364-76.


Slimak MA, Ables JL, Frahm S, Antolin-Fontes B, Santos-Torres J, Moretti M, Gotti C, Ibañez-Tallon I.

Habenular expression of rare missense variants of the β4 nicotinic receptor subunit alters nicotine consumption.

Front Hum Neurosci. 2014 Jan 27;8:12.


Haseleu J, Omerbašić D, Frenzel H, Gross M, Lewin GR.

Water-induced finger wrinkles do not affect touch acuity or dexterity in handling wet objects.

PLoSOne. 2014 Jan 8;9(1):e84949. doi: 10.1371/journal.pone.0084949. eCollection 2014.




Görlich A, Antolin-Fontes B, Ables JL, Frahm S, Slimak MA, Dougherty JD, Ibañez-Tallon I.

Reexposure to nicotine during withdrawal increases the pacemaking activity of cholinergic habenular neurons.

Proc Natl Acad Sci U S A.2013 Oct 15;110(42):17077-82


Burgert T, Schmidt V, Caglayan S, Lin F, Füchtbauer A, Füchtbauer EM, Nykjaer  A, Carlo AS, Willnow TE.

SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes.

Mol Cell Biol. 2013 Nov;33(21):4308-20.


Matkovic T*, Siebert M*, Knoche E*, Depner H, Mertel S, Owald D, Schmidt M, Thomas U, Sickmann A, Kamin D, Hell SW, Bürger J, Hollmann C, Mielke T, Wichmann  C, Sigrist SJ.

The Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles.

J Cell Biol. 2013 Aug 19;202(4):667-83.


Veeramah KR, Johnstone L, Karafet TM, Wolf D, Sprissler R, Salogiannis J, Barth-Maron A, Greenberg ME, Stuhlmann T, Weinert S, Jentsch TJ, Pazzi M, Restifo LL, Talwar D, Erickson RP, Hammer MF.

Exome sequencing reveals new causal mutations in children with epileptic encephalopathies.

Epilepsia. 2013 Jul;54(7):1270-81


Bulavina L, Szulzewsky F, Rocha A, Krabbe G, Robson SC, Matyash V, Kettenmann H.

NTPDase1 activity attenuates microglial phagocytosis.

Purinergic Signal. 2013 Jun;9(2):199-205


Volkmer H, Schreiber J, Rathjen FG.

Regulation of Adhesion by Flexible Ectodomains of IgCAMs.

Neurochem Res. 2013 Jun;38(6):1092-9.


Spitzmaul G, Tolosa L, Winkelman BH, Heidenreich M, Frens MA, Chabbert C, de Zeeuw CI, Jentsch TJ.

Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models.

J Biol Chem. 2013 Mar 29;288(13):9334-44.


Klempin F*, Beis D*, Mosienko V, Kempermann G, Bader M, Alenina N.

Serotonin is required for exercise-induced adult hippocampal neurogenesis.

J Neurosci. 2013 May 8;33(19):8270-5.


Krabbe G, Halle A, Matyash V, Rinnenthal JL, Eom GD, Bernhardt U, Miller KR, Prokop S, Kettenmann H, Heppner FL.

Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology.

PLoS One. 2013;8(4):e60921.


Narboux-Nême N, Angenard G, Mosienko V, Klempin F, Pitychoutis PM, Deneris E, Bader M, Giros B, Alenina N, Gaspar P.

Postnatal growth defects in mice with constitutive depletion of central serotonin.

ACS Chem Neurosci. 2013 Jan 16;4(1):171-81.


Kononenko NL, Diril MK, Puchkov D, Kintscher M, Koo SJ, Pfuhl G, Winter Y, Wienisch M, Klingauf J, Breustedt J, Schmitz D, Maritzen T, Haucke V.

Compromised fidelity of endocytic synaptic vesicle protein sorting in the absence of stonin 2.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E526-35.


Scharff C, Adam I. Neurogenetics of birdsong.

Curr Opin Neurobiol. 2013 Feb;23(1):29-36.


Bormuth I, Yan K, Yonemasu T, Gummert M, Zhang M, Wichert S, Grishina O, Pieper A, Zhang W, Goebbels S, Tarabykin V, Nave KA, Schwab MH. (2013)

Neuronal Basic Helix-Loop-Helix Proteins Neurod2/6 Regulate Cortical Commissure Formation before Midline Interactions.

J Neurosci. 9;33(2):641-51.


Carlo AS, Gustafsen C, Mastrobuoni G, Nielsen MS, Burgert T, Hartl D, Rohe M,  Nykjaer A, Herz J, Heeren J, Kempa S, Petersen CM, Willnow TE. (2013)

The Pro-Neurotrophin Receptor Sortilin Is a Major Neuronal Apolipoprotein E Receptor for Catabolism of Amyloid-β Peptide in the Brain.

J Neurosci. 2;33(1):358-70.




Willnow TE, Christ A, Hammes A. (2012)

Endocytic receptor-mediated control of morphogen signaling.

Development. ;139(23):4311-9.


 Maritzen T, Koo SJ, Haucke V.(2012)

Turning CALM into excitement: AP180 and CALM in endocytosis and disease.

Biol Cell. ;104(10):588-602.


Bröhl D, Vasyutina E, Czajkowski MT, Griger J, Rassek C, Rahn HP, Purfürst B, Wende H, Birchmeier C. (2012)

Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on Notch signals.

Dev Cell.23(3):469-81.


Brand J, Smith ES, Schwefel D, Lapatsina L, Poole K, Omerbašić D, Kozlenkov A, Behlke J, Lewin GR, Daumke O. (2012)

A stomatin dimer modulates the activity of acid-sensing ion channels.

EMBO J.31(17):3635-46.


Stock K, Kumar J, Synowitz M, Petrosino S, Imperatore R, Smith ES, Wend P, Purfürst B, Nuber UA, Gurok U, Matyash V, Wälzlein JH, Chirasani SR, Dittmar G, Cravatt BF, Momma S, Lewin GR, Ligresti A, De Petrocellis L, Cristino L, Di Marzo V, Kettenmann H, Glass R. (2012)

Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1.

Nat Med. 18,1232–1238


Tress O, Maglione M, May D, Pivneva T, Richter N, Seyfarth J, Binder S, Zlomuzica A, Seifert G, Theis M, Dere E, Kettenmann H, Willecke K. (2012)

Panglial gap junctional communication is essential for maintenance of myelin in the CNS.

J Neurosci.  30;32(22):7499-518.


Mosienko V, Bert B, Beis D, Matthes S, Fink H, Bader M, Alenina N. (2012)

Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin.

Transl Psychiatry.  29;2:e122.


Caglayan S, Bauerfeind A, Schmidt V, Carlo AS, Prabakaran T, Hübner N, Willnow TE

. Identification of Alzheimer disease risk genotype that predicts efficiency of SORL1 expression in the brain.

Arch Neurol. 69(3):373-9.


Krabbe G, Matyash V, Pannasch U, Mamer L, Boddeke HW, Kettenmann H. (2012)

Activation of serotonin receptors promotes microglial injury-induced motility but attenuates phagocytic activity.

Brain Behav Immun. 26(3):419-28.


Christ A, Christa A, Kur E, Lioubinski O, Bachmann S, Willnow TE, Hammes A.(2012)

LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals.

Dev Cell. ;22(2):268-78.:


Heller EA, Zhang W, Selimi F, Earnheart JC, Ślimak MA, Santos-Torres J, Ibañez-Tallon I, Aoki C, Chait BT, Heintz N. (2012)

The biochemical anatomy of cortical inhibitory synapses.

PLoS One. 2012;7(6):e39572. doi:10.1371/journal.pone.0039572.





Liu KS* , Siebert M* , Mertel S*, Knoche E*, Wegener S*, Wichmann C, Matkovic T, Muhammad K, Depner H, Mettke C, Bückers J, Hell SW, Müller M, Davis GW, Schmitz D, Sigrist SJ. (2011)

RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release.

Science. ;334(6062):1565-9.


Smith ES, Omerbašić D, Lechner SG, Anirudhan G, Lapatsina L, Lewin GR. (2011)

The molecular basis of acid insensitivity in the African naked mole-rat.



Krabbe G, Matyiash V, Pannasch U, Mamer L, Boddeke HW, Kettenmann H. (2011)

Activation of serotonin receptors promotes microglial injury-induced motility butbattenuates phagocytic activity.

Brain Behav Immun. (in press)


Heidenreich M, Lechner SG, Vardanyan V, Wetzel C, Cremers CW, De Leenheer EM, Aránguez G, Moreno-Pelayo MA, Jentsch TJ, Lewin GR. (2011)

KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man.

Nat Neurosci. 2011 Nov 20. doi: 10.1038/nn.2985. [Epub ahead of print]


Maier, N and Tejero-Cantero, A and Dorrn, AL and Winterer, J and Beed, PS and Morris, G and Kempter, R and Poulet, JFA and Leibold, C and Schmitz, D. (2011)

Coherent phasic excitation during hippocampal ripples.

Neuron 72 (1): 137-152.


Liskovykh M, Chuykin I, Ranjan A, Safina D, Popova E, Tolkunova E, Mosienko V, Minina JM, Zhdanova NS, Mullins JJ, Bader M, Alenina N, Tomilin A. (2011)

Derivation, characterization, and stable transfection of induced pluripotent stem cells from Fischer344 rats.

PLoS One. 2011;6(11):e27345.


Santos-Torres, J and Slimak, MA and Auer, S and Ibanez-Tallon, I.

Cross-reactivity of ASIC and Na+/H+ exchanger antagonists with nicotinic acetylcholine receptors.

Journal of Physiology 12 September 2011 (In Press)


Koo SJ, Markovic S, Puchkov D, Mahrenholz CC, Beceren-Braun F, Maritzen T, Dernedde J, Volkmer R, Oschkinat H, Haucke V.

SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapses.

PNAS 2011 Aug 1. [Epub ahead of print


Chiang LY, Poole K, Oliveira BE, Duarte N, Sierra YA, Bruckner-Tuderman L, Koch M, Hu J, Lewin GR

Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons.

Nat Neurosci. 2011 Jul 3. doi:10.1038/nn.2873


Koo SJ, Puchkov D, Haucke V. (2011)

AP180 and CALM: Dedicated endocytic adaptors for the retrieval of synaptobrevin 2 at synapses

Cell Logist. 2011 Jul;1(4):168-172.


Frahm, S, Slimak, MA, Ferrarese, L, Santos-Torres, J, Antolin-Fontes, B and Auer, S and Filkin, S and Pons, S and Fontaine, JF and Tsetlin, V and Maskos, U and Ibanez-Tallon, I.

Aversion to nicotine is regulated by the balanced activity of beta4 and alpha5 nicotinic receptor subunits in the medial habenula.

Neuron 70 (3): 522-535. 12 May 2011


Kur, E and Christa, A and Veth, KN and Gajera, CR and Andrade-Navarro, MA and Zhang, J and Willer, JR and Gregg, RG and Abdelilah-Seyfried, S and Bachmann, S and Link, BA and Hammes, A and Willnow, TE.

Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development.

Developmental Dynamics 31 March 2011 (In Press)




Granata A, Koo SJ, Haucke V, Schiavo G, Warner TT.

CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process.

EMBO J. 2010 Nov 19.


Christ A, Terryn S, Schmidt V, Christensen EI, Huska MR, Andrade-Navarro MA, Hübner N, Devuyst O, Hammes A, Willnow TE.

The soluble intracellular domain of megalin does not affect renal proximal tubular function in vivo.

Kidney Int. 2010 Sep;78(5):473-7.


Gajera CR, Emich H, Lioubinski O, Christ A, Beckervordersandforth-Bonk R, Yoshikawa K, Bachmann S, Christensen EI, Götz M, Kempermann G, Peterson AS,Willnow TE, Hammes A.

LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche.

J Cell Sci. 2010 Jun 1;123(Pt 11):1922-30.


Tzingounis AV*, Heidenreich M*, Kharkovets T, Spitzmaul G, Jensen HS, Nicoll RA,Jentsch TJ. (2010)

The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus.

PNAS. 107(22):10232-7.


Warren WC, Clayton DF, Ellegren H, Arnold AP, Hillier LW, Künstner A, Searle S, White S, Vilella AJ, Fairley S, Heger A, Kong L, Ponting CP, Jarvis ED, Mello  CV, Minx P, Lovell P, Velho TA, Ferris M, Balakrishnan CN, Sinha S, Blatti C, London SE, Li Y, Lin YC, George J, Sweedler J, Southey B, Gunaratne P, Watson M, Nam K, Backström N, Smeds L, Nabholz B, Itoh Y, Whitney O, Pfenning AR, Howard J, Völker M, Skinner BM, Griffin DK, Ye L, McLaren WM, Flicek P, Quesada V, Velasco G, Lopez-Otin C, Puente XS, Olender T, Lancet D, Smit AF, Hubley R, Konkel MK, Walker JA, Batzer MA, Gu W, Pollock DD, Chen L, Cheng Z, Eichler EE, Stapley J, Slate J, Ekblom R, Birkhead T, Burke T, Burt D, Scharff C, Adam I, Richard H, Sultan M, Soldatov A, Lehrach H, Edwards SV, Yang SP, Li X, Graves T, Fulton L, Nelson J, Chinwalla A, Hou S, Mardis ER, Wilson RK.

The genome of a songbird.

Nature. 2010 Apr 1;464(7289):757-62.


Chuykin I, Lapidus I, Popova E, Vilianovich L, Mosienko V, Alenina N, Binas B, Chai G, Bader M, Krivokharchenko A.

Characterization of trophoblast and extraembryonic endoderm cell lineages derived from rat preimplantation embryos.

PLoS One. 2010 Mar 29;5(3):e9794.


Auer S, Stürzebecher AS, Jüttner R, Santos-Torres J, Hanack C, Frahm S, Liehl B, Ibañez-Tallon I. Silencing neurotransmission with membrane-tethered toxins.

Nat Methods. 2010 Mar;7(3):229-36.


Patzke C, Max KE, Behlke J, Schreiber J, Schmidt H, Dorner AA, Kröger S, Henning M, Otto A, Heinemann U, Rathjen FG.

The coxsackievirus-adenovirus receptor reveals complex homophilic and heterophilic interactions on neural cells.

J Neurosci. 2010 Feb 24;30(8):2897-910.


Zhang J, Piontek J, Wolburg H, Piehl C, Liss M, Otten C, Christ A, Willnow TE, Blasig IE, Abdelilah-Seyfried S.

 Establishment of a neuroepithelial barrier by Claudin5a is essential for zebrafish brain ventricular lumen expansion.

Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1425-30.


Kahlfeldt N, Vahedi-Faridi A, Koo SJ, Schäfer JG, Krainer G, Keller S, Saenger W, Krauss M, Haucke V.

Molecular basis for association of PIPKI gamma-p90 with clathrin adaptor AP-2.

J Biol Chem. 2010 Jan 22;285(4):2734-49.


Matthes S, Mosienko V, Bashammakh S, Alenina N, Bader M.

Tryptophan hydroxylase as novel target for the treatment of depressive disorders.

Pharmacology. 2010;85(2):95-109.



Cholewa J, Pflüger HJ.

Descending unpaired median neurons with bilaterally symmetrical axons in the suboesophageal ganglion of Manduca sexta larvae.

Zoology (Jena). 2009;112(4):251-62.


Alenina N, Kikic D, Todiras M, Mosienko V, Qadri F, Plehm R, Boyé P, Vilianovitch L, Sohr R, Tenner K, Hörtnagl H, Bader M.

Growth retardation and altered autonomic control in mice lacking brain serotonin.

Proc Natl Acad Sci USA. 2009 Jun 23;106(25):10332-7.


Markovic DS, Vinnakota K, Chirasani S, Synowitz M, Raguet H, Stock K, Sliwa M, Lehmann S, Kälin R, van Rooijen N, Holmbeck K, Heppner FL, Kiwit J, Matyash V, Lehnardt S, Kaminska B, Glass R, Kettenmann H.

Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion.

Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12530-5.