Prof. Dr. Victor Tarabykin


Institute of Cell Biology and Neurobiology

Charité - Universitätsmedizin Berlin

CCM: Campus Charité Mitte




Research Interest:

We are interested in the cellular and molecular mechanisms underlying cell fate specification in the mouse cerebral cortex. We focus on the mechanisms controlling the generation, migration and axonal guidance of neurons of different cortical layers and areas. Towards this end we apply a combination of genetic, molecular and cell biological approaches to identify and characterize genes that control cortical development.



1984 - 1993 : Studies in Medicine and Biology, Russian State Medical University, Moscow

1990 - 1993: Thesis at the Inst. Of Bioorganic Chemistry, Moscow, Russia. Advisor: Prof. Dr. A. Zarayskii

1993 - 1995: PhD in molecular biology PhD Thesis at the Inst. Of Bioorganic Chemistry, Moscow, Russia. Advisor: Prof. Dr. S. Lukyanov

2/2008: Habilitation (Molecular Biology and Genetics) at University of Göttingen


Professional experience

1996 - 2001: Postdoctoral fellow in the Department of Peter Gruss at the MPI of Biophysical Chemistry, Göttingen.

2002 - 2007: Group leader in the Department of Molecular Biology of Neuronal Signals, Max Planck Institute of Experimental Medicine, Göttingen

2008 - 2009: Independent Group Leader at Max Planck Institute of Experimental Medicine, Göttingen

Since 3/2009: W3 Heisenberg Professor, Institute of Cell Biology and Neurobiology, Center of Anatomy, Charite - Universitätsmedizin, Berlin


selected Publications

Seuntjens E, Nityanandam A, Miquelajauregui A, Debruyn J, Stryjewska A, Goebbels S, Nave KA, Huylebroeck D, Tarabykin V (2009). Sip1 regulates sequential fate decisions by feedback signaling from postmitotic neurons to progenitors.

Nat Neurosci. 12, 1373-1380


Britanova O, de Juan Romero C, Cheung A, Kwan KY, Schwark M, Gyorgy A, Vogel T, Akopov S, Mitkovski M, Agoston D, Sestan N, Molnár Z, Tarabykin V (2008). Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex.

Neuron 57, 378-92


Miquelajauregui A, Van de Putte T, Polyakov A, Nityanandam A, Boppana S, Seuntjens E, Karabinos A, Higashi Y, Huylebroeck D, Tarabykin V (2007). Smad-interacting protein-1 (Zfhx1b) acts upstream of Wnt signaling in the mouse hippocampus and controls its formation.

Proc. Natl. Acad. Sci. U.S.A. 104, 12919-24


Britanova O, Depew MJ, Schwark M, Thomas BL, Miletich I, Sharpe P, Tarabykin V (2006). Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development.

Am. J. Hum. Genet. 79, 668-78


Britanova O, Alifragis P, Junek S, Jones K, Gruss P, Tarabykin V (2006). A novel mode of tangential migration of cortical projection neurons.

Dev. Biol. 298, 299-311


Britanova O, Akopov S, Lukyanov S, Gruss P, Tarabykin V (2005). Novel transcription factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell-type-dependent expression in the developing mouse CNS.

Eur. J. Neurosci. 21, 658-68


Tarabykin V, Stoykova A, Usman N, Gruss P (2001). Cortical upper layer neurons derive from the subventricular zone as indicated by Svet1 gene expression.

Development 128, 1983-93