Publikationen



2017

Cao P.; Falcke M.; Sneyd J.
Mapping interpuff interval distribution to the properties of inositol trisphosphate receptors
Biophysical Journal 112 (10): 2138-2146 (2017-05-23)



Moenke G.; Cristiano E.; Finzel A.; Friedrich D.; Herzel H.; Falcke M.; Loewer A.
Excitability in the p53 network mediates robust signaling with tunable activation thresholds in single cells
Scientific Reports 7: 46571 (2017-04-18)



Benoist D.; Dubes V.; Roubertie F.; Gilbert S.H.; Charron S.; Constantin M.; Elbes D.; Vieillot D.; Quesson B.; Cochet H.; Haissaguerre M.; Rooryck C.; Bordachar P.; Thambo J.B.; Bernus O.
Proarrhythmic remodelling of the right ventricle in a porcine model of repaired tetralogy of Fallot
Heart 103 (5): 347-354 (2017-03)



2016

Falcke M.
Concentration profiles of actin-binding molecules in lamellipodia
Physica D: Nonlinear Phenomena 318-319: 50-57 (2016-04-01)



Dupont G.; Falcke M.; Kirk V.; Sneyd J.
Models of calcium signalling
Interdisciplinary Applied Mathematics 43: (2016)



2015

Vierheller J.; Neubert W.; Falcke M.; Gilbert S.H.; Chamakuri N.
A multiscale computational model of spatially resolved calcium cycling in cardiac myocytes: from detailed cleft dynamics to the whole cell concentration profiles
Frontiers in Physiology 6: 255 (2015-09-24)



Charron S.; Roubertie F.; Benoist D.; Dubes V.; Gilbert S.H.; Constantin M.; Vieillot D.; Elbes D.; Quesson B.; Bordachar P.; Haissaguerre M.; Bernus O.; Thambo J.B.; Rooryck C.
Identification of region-specific myocardial gene expression patterns in a chronic swine model of repaired tetralogy of fallot
PLoS ONE 10 (8): e0134146 (2015-08-07)



Razbin M.; Falcke M.; Benetatos P.; Zippelius A.
Mechanical properties of branched actin filaments
Physical Biology 12 (4): 046007 (2015-06-04)



Bernus O.; Radjenovic A.; Trew M.L.; LeGrice I.J.; Sands G.B.; Magee D.R.; Smaill B.H.; Gilbert S.H.
Comparison of diffusion tensor imaging by cardiovascular magnetic resonance and gadolinium enhanced 3D image intensity approaches to investigation of structural anisotropy in explanted rat hearts
Journal of Cardiovascular Magnetic Resonance 17 (1): 31 (2015-04-29)



Gutbrod S.R.; Walton R.; Gilbert S.; Meillet V.; Jais P.; Hocini M.; Haissaguerre M.; Dubois R.; Bernus O.; Efimov I.
Quantification of the transmural dynamics of atrial fibrillation by simultaneous endocardial and epicardial optical mapping in an acute sheep model
Circulation Arrhythmia and Electrophysiology 8 (2): 456-465 (2015-04)



Magee D.; Song Y.; Gilbert S.; Roberts N.; Wijayathunga N.; Wilcox R.; Bulpitt A.; Treanor D.
Histopathology in 3D: from three-dimensional reconstruction to multi-stain and multi-modal analysis
Journal of Pathology Informatics 6: 6 (2015-02-24)



2014

Thurley K.; Tovey S.C.; Moenke G.; Prince V.L.; Meena A.; Thomas A.P.; Skupin A.; Taylor C.W.; Falcke M.
Reliable encoding of stimulus intensities within random sequences of intracellular Ca2+ spikes
Science Signaling 7 (331): ra59 (2014-06-24)



Falcke M.; Zimmermann J.
Polymerization, bending, tension: What happens at the leading edge of motile cells?
European Physical Journal - Special Topics 223 (7): 1353-1372 (2014-06)



Shah C.; Hegde B.G.; Moren B.; Behrmann E.; Mielke T.; Moenke G.; Spahn C.M.; Lundmark R.; Daumke O.; Langen R.
Structural insights into membrane interaction and caveolar targeting of dynamin-like EHD2
Structure 22 (3): 409-420 (2014-03-04)



Zimmermann J.; Falcke M.
Formation of transient lamellipodia
PLoS ONE 9 (2): e87638 (2014-02-05)



2013

Cao P.; Donovan G.; Falcke M.; Sneyd J.
A stochastic model of calcium puffs based on single-channel data
Biophysical Journal 105 (5): 1133-1142 (2013-09-03)



Zimmermann J.; Falcke M.
On the existence and strength of stable membrane protrusions
New Journal of Physics 15: 015021 (2013-01)



2012

Moenke G.; Falcke M.; Thurley K.
Hierarchic stochastic modelling applied to intracellular Ca(2+) signals
PLoS ONE 7 (12): e51178 (2012-12-27)



Gholami A.; Enculescu M.; Falcke M.
Membrane waves driven by forces from actin filaments
New Journal of Physics 14: 115002 (2012-11-02)



Thurley K.; Skupin A.; Thul R.; Falcke M.
Fundamental properties of Ca(2+) signals
Biochimica et Biophysica Acta - General Subjects 1820 (8): 1185-1194 (2012-08)



Nagaiah C.; Ruediger S.; Warnecke G.; Falcke M.
Adaptive space and time numerical simulation of reaction-diffusion models for intracellular calcium dynamics
Applied Mathematics and Computation 218 (20): 10194-10210 (2012-06-15)



Zimmermann J.; Brunner C.; Enculescu M.; Goegler M.; Ehrlicher A.; Kaes J.; Falcke M.
Actin filament elasticity and retrograde flow shape the force-velocity relation of motile cells
Biophysical Journal 102 (2): 287-295 (2012-01-18)



Enculescu M.; Falcke M.
Modeling morphodynamic phenotypes and dynamic regimes of cell motion
Advances in Experimental Medicine and Biology 736 (3): 337-358 (2012)



Schendel T.; Thul R.; Sneyd J.; Falcke M.
How does the ryanodine receptor in the ventricular myocyte wake up: by a single or by multiple open L-type Ca(2+) channels?
European Biophysics Journal 41 (1): 27-39 (2012-01)



Skupin A.; Thurley K.
Calcium signaling: from single channels to pathways
Advances in Experimental Medicine and Biology 740: 531-551 (2012)



2011

Thurley K.; Smith I.F.; Tovey S.C.; Taylor C.W.; Parker I.; Falcke M.
Timescales of IP(3)-evoked Ca(2+) spikes emerge from Ca(2+) puffs only at the cellular level
Biophysical Journal 101 (11): 2638-2644 (2011-12-07)



Enculescu M.; Falcke M.
Actin-based propulsion of spatially extended objects
New Journal of Physics 13: 053040 (2011-05)



Schuetze J.; Mair T.; Hauser M.J.; Falcke M.; Wolf J.
Metabolic synchronization by traveling waves in yeast cell layers
Biophysical Journal 100 (4): 809-813 (2011-02-16)



Thurley K.; Falcke M.
Derivation of Ca2+ signals from puff properties reveals that pathway function is robust against cell variability but sensitive for control
Proceedings of the National Academy of Sciences of the United States of America 108 (1): 427-432 (2011-01-04)



2010

Faber M.; Enculescu M.; Falcke M.
Filament capping and nucleation in actin-based motility
European Physical Journal - Special Topics 191 (1): 147-158 (2010-12)



Zimmermann J.; Enculescu M.; Falcke M.
Leading-edge-gel coupling in lamellipodium motion
Physical Review E 82 (5): 051925 (2010-11-18)



Skupin A.; Falcke M.
Statistical analysis of calcium oscillations
European Physical Journal - Special Topics 187 (1): 231-240 (2010-09)



Skupin A.; Kettenmann H.; Falcke M.
Calcium signals driven by single channel noise
PLoS Computational Biology 6 (8): e1000870 (2010-08-05)



Enculescu M.; Sabouri-Ghomi M.; Danuser G.; Falcke M.
Modeling of protrusion phenotypes driven by the actin-membrane interaction
Biophysical Journal 98 (8): 1571-1581 (2010-04-21)



Schendel T.; Falcke M.
Efficient and detailed model of the local Ca(2+) release unit in the ventricular cardiac myocyte
Genome Informatics 22 (1): 142-155 (2010-01)



2009

Thul R.; Thurley K.; Falcke M.
Toward a predictive model of Ca2+ puffs
Chaos 19 (3): 037108 (2009-09-18)



Skupin A.; Falcke M.
From puffs to global Ca2+ signals: how molecular properties shape global signals
Chaos 19 (3): 037111 (2009-09-18)



Falcke M.
Introduction to focus issue: intracellular Ca2+ dynamics--a change of modeling paradigm?
Chaos 19 (3): 037101 (2009-09)



Zeller S.; Ruediger S.; Engel H.; Sneyd J.; Warnecke G.; Parker I.; Falcke M.
Modeling of the modulation by buffers of Ca2+ release through clusters of IP3 receptors
Biophysical Journal 97 (4): 992-1002 (2009-08-19)



Higgins E.R.; Schmidle H.; Falcke M.
Waiting time distributions for clusters of IP3 receptors
Journal of Theoretical Biology 259 (2): 338-349 (2009-07-21)



Gin E.; Falcke M.; Wagner L.E.; Yule D.I.; Sneyd J.
A kinetic model of the inositol trisphosphate receptor based on single-channel data
Biophysical Journal 96 (10): 4053-4062 (2009-05-20)



Gin E.; Falcke M.; Wagner L.E.; Yule D.I.; Sneyd J.
Markov chain Monte Carlo fitting of single-channel data from inositol trisphosphate receptors
Journal of Theoretical Biology 257 (3): 460-474 (2009-04-07)



Taufiq-Ur-Rahman ; Skupin A.; Falcke M.; Taylor C.W.
Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+
Nature 458 (7238): 655-659 (2009-04-02)



2008

Falcke M.
Announcement: Focus issue on "Intracellular Ca(2+) Dynamics- A Change of Modeling Paradigm?"
Chaos 18 (4): 040201 (2008-12)



Nagaiah C.; Ruediger S.; Warnecke G.; Falcke M.
Adaptive numerical simulation of intracellular calcium dynamics using domain decomposition methods
Applied Numerical Mathematics 58 (11): 1658-1674 (2008-11)



Leonhardt H.; Zaks M.A.; Falcke M.; Schimansky-Geier L.
Stochastic hierarchical systems: excitable dynamics
Journal of Biological Physics 34 (5): 521-538 (2008-10)



Enculescu M.; Gholami A.; Falcke M.
Dynamic regimes and bifurcations in a model of actin-based motility
Physical Review E 78 (3 Pt 1): 031915 (2008-09)



Skupin A.; Falcke M.
The role of IP(3)R clustering in Ca(2+) signalinG
Genome Informatics 20: 15-24 (2008-06)



Skupin A.; Kettenmann H.; Winkler U.; Wartenberg M.; Sauer H.; Tovey S.C.; Taylor C.W.; Falcke M.
How does intracellular Ca2+ oscillate: by chance or by the clock?
Biophysical Journal 94 (6): 2404-2411 (2008-03-15)



Gholami A.; Falcke M.; Frey E.
Velocity oscillations in actin-based motility
New Journal of Physics 10: 033022 (2008-03-12)



Schipke C.G.; Heidemann A.; Skupin A.; Peters O.; Falcke M.; Kettenmann H.
Temperature and nitric oxide control spontaneous calcium transients in astrocytes
Cell Calcium 43 (3): 285-295 (2008-03)



2007

Bentele K.; Falcke M.
Quasi-steady approximation for ion channel currents
Biophysical Journal 93 (8): 2597-2608 (2007-10-15)



Straube R.; Ward M.J.; Falcke M.
Reaction rate of small diffusing molecules on a cylindrical membrane
Journal of Statistical Physics 129 (2): 377-405 (2007-10)



Ruediger S.; Shuai J.W.; Huisinga W.; Nagaiah C.; Warnecke G.; Parker I.; Falcke M.
Hybrid stochastic and deterministic simulations of calcium blips
Biophysical Journal 93 (6): 1847-1857 (2007-09-15)



Thul R.; Falcke M.
Waiting time distributions for clusters of complex molecules
Europhysics Letters 79 (3): 38003 (2007-08)



Prager T.; Falcke M.; Schimansky-Geier L.; Zaks M.A.
Non-Markovian approach to globally coupled excitable systems
Physical Review E 76 (1 Pt 1): 011118 (2007-07-24)



Straube R.; Falcke M.
Reversible clustering under the influence of a periodically modulated binding rate
Physical Review E 76 (1 Pt 1): 010402 (2007-07)



Roeder G.; Bordyugov G.; Engel H.; Falcke M.
Wave trains in an excitable FitzHugh-Nagumo model: bistable dispersion relation and formation of isolas
Physical Review E 75 (3 Pt 2): 036202 (2007-03)



2006

Thul R.; Falcke M.
Frequency of elemental events of intracellular Ca(2+) dynamics
Physical Review E 73 (6 Pt 1): 061923 (2006-06)



2005

Sneyd J.; Falcke M.
Models of the inositol trisphosphate receptor
Progress in Biophysics and Molecular Biology 89 (3): 207-245 (2005-11)



Thul R.; Falcke M.
Reactive clusters on a membrane
Physical Biology 2 (1): 51-59 (2005-03)



2004

Thul R.; Falcke M.
Stability of membrane bound reactions
Physical Review Letters 93 (18): 188103 (2004-10-29)



Sneyd J.; Falcke M.; Dufour J.F.; Fox C.
A comparison of three models of the inositol trisphosphate receptor
Progress in Biophysics and Molecular Biology 85 (2-3): 121-140 (2004-06)



Thul R.; Falcke M.
Release currents of IP(3) receptor channel clusters and concentration profiles
Biophysical Journal 86 (5): 2660-2673 (2004-05)



Falcke M.
Reading the patterns in living cells - the physics of Ca2+ signaling
Advances in Physics 53 (3): 255-440 (2004-05)



2003

Falcke M.; Li Y.; Lechleiter J.D.; Camacho P.
Modeling the dependence of the period of intracellular Ca2+ waves on SERCA expression
Biophysical Journal 85 (3): 1474-1481 (2003-09)



Falcke M.
Deterministic and stochastic models of intracellular Ca2+ waves
New Journal of Physics 5: 96 (2003-07)



Falcke M.
Buffers and oscillations in intracellular Ca2+ dynamics
Biophysical Journal 84 (1): 28-41 (2003-01)



Falcke M.
On the role of stochastic channel behavior in intracellular Ca2+ dynamics
Biophysical Journal 84 (1): 42-56 (2003-01)



2000

Falcke M.; Tsimring L.; Levine H.
Stochastic spreading of intracellular Ca(2+) release
Physical Review E 62 (2 Pt B): 2636-2643 (2000-08)



Baer M.; Falcke M.; Levine H.; Tsimring L.S.
Discrete stochastic modeling of calcium channel dynamics
Physical Review Letters 84 (24): 5664-5667 (2000-06-12)



Falcke M.; Huerta R.; Rabinovich M.I.; Abarbanel H.D.; Elson R.C.; Selverston A.I.
Modeling observed chaotic oscillations in bursting neurons: the role of calcium dynamics and IP3
Biological Cybernetics 82 (6): 517-527 (2000-06)



Falcke M.; Or-Guil M.; Baer M.
Dispersion gap and localized spiral waves in a model for intracellular Ca2+ dynamics
Physical Review Letters 84 (20): 4753-4756 (2000-05-15)



1999

Falcke M.; Hudson J.L.; Camacho P.; Lechleiter J.D.
Impact of mitochondrial Ca2+ cycling on pattern formation and stability
Biophysical Journal 77 (1): 37-44 (1999-07)



Falcke M.; Baer M.; Lechleiter J.D.; Hudson J.L.
Spiral breakup and defect dynamics in a model for intracellular Ca2+ dynamics
Physica D 129 (3-4): 236-252 (1999-05-15)



1998

Falcke M.; Levine H.
Pattern selection by gene expression in Dictyostelium discoideum
Physical Review Letters 80 (17): 3875-3878 (1998-04)



1997

Arndt J.; Herzel H.; Bose S.; Falcke M.; Scholl E.
Quantification of transients using empirical orthogonal functions
Chaos Solitons & Fractals 8 (12): 1911-1920 (1997-12)



Falcke M.; Engel H.
Traveling pulses in anisotropic oscillatory media with global coupling
Physical Review E 56 (1): 635-641 (1997)



1995

Falcke M.; Engel H.; Neufeld M.
Cluster formation, standing waves, and stripe patterns in oscillatory active media with local and global coupling
Physical Review E 52 (1): 763-771 (1995-07)



1994

Falcke M.; Engel H.
Pattern-formation during the CO oxidation on Pt(110) surfaces under global coupling
Journal of Chemical Physics 101 (7): 6255-6263 (1994-10)



Baer M.; Hildebrand M.; Eiswirth M.; Falcke M.; Engel H.; Neufeld M.
Chemical turbulence and standing waves in a surface reaction model: The influence of global coupling and wave instabilities
Chaos 4 (3): 499-508 (1994-09)



Falcke M.; Engel H.
Influence of global coupling through the gas phase on the dynamics of CO oxidation on Pt(110)
Physical Review E 50 (2): 1353-1359 (1994-08)



1992

Falcke M.; Baer M.; Engel H.; Eiswirth M.
Traveling waves in the CO oxidation on Pt(110) - Theory
Journal of Chemical Physics 97 (6): 4555-4563 (1992-09-15)



Baer M.; Falcke M.; Eiswirth M.
Dispersion-relation and spiral rotation in an excitable surface-reaction
Physica A 188 (1-3): 78-88 (1992-09-01)



Baer M.; Falcke M.; Zuelicke C.; Engel H.; Eiswirth M.; Ertl G.
Reaction fronts and pulses in the CO oxidation on Pt: therortical analysis
Surface Science 269-270 (Pt A): 471-475 (1992-05-15)