Publications



2017

Bergeron V.; Ghislain J.; Vivot K.; Tamarina N.; Philipson L.H.; Fielitz J.; Poitout V.
Deletion of protein kinase D1 in pancreatic beta cells impairs insulin secretion in high-fat fed mice
Diabetes : (2017-10)



Zhu X.; Kny M.; Schmidt F.; Hahn A.; Wollersheim T.; Kleber C.; Weber-Carstens S.; Fielitz J.
Secreted frizzled-related protein 2 and inflammation-induced skeletal muscle atrophy
Critical Care Medicine 45 (2): e169-e183 (2017-02)



Huang N.; Kny M.; Riediger F.; Busch K.; Schmidt S.; Luft F.C.; Slevogt H.; Fielitz J.
Deletion of Nlrp3 protects from inflammation-induced skeletal muscle atrophy
Intensive Care Medicine Experimental 5 (1): 3 (2017-01-17)



Fernandez A.M.; Hernandez-Garzon E.; Perez-Domper P.; Perez-Alvarez A.; Mederos S.; Matsui T.; Santi A.; Trueba-Saiz A.; Garcia-Guerra L.; Pose-Utrilla J.; Fielitz J.; Olson E.N.; Fernandez de la Rosa R.; Garcia Garcia L.; Pozo M.A.; Iglesias T.; Araque A.; Soya H.; Perea G.; Martin E.D.; Torres Aleman I.
Insulin regulates astrocytic glucose handling through cooperation with IGF-I
Diabetes 66 (1): 64-74 (2017-01)



2016

Fielitz J.
Cancer cachexia-when proteasomal inhibition is not enough.
Journal of Cachexia Sarcopenia and Muscle 7 (3): 239-245 (2016-06)



Koch S.; Bierbrauer J.; Haas K.; Wolter S.; Grosskreutz J.; Luft F.C.; Spies C.D.; Fielitz J.; Weber-Carstens S.
Critical illness polyneuropathy in ICU patients is related to reduced motor nerve excitability caused by reduced sodium permeability
Intensive Care Medicine Experimental 4 (1): 10 (2016-05-20)



Lodka D.; Pahuja A.; Geers-Knoerr C.; Scheibe R.; Nowak M.; Hamati J.; Koehncke C.; Purfuerst B.; Kanashova T.; Schmidt S.; Glass D.J.; Morano I.; Heuser A.; Kraft T.; Bassel-Duby R.; Olson E.N.; Dittmar G.; Sommer T.; Fielitz J.
Muscle RING-finger 2 and 3 maintain striated-muscle structure and function
Journal of Cachexia Sarcopenia and Muscle 7 (2): 165-180 (2016-05)



2015

Du Bois P.; Pablo Tortola C.; Lodka D.; Kny M.; Schmidt F.; Song K.; Schmidt S.; Bassel-Duby R.; Olson E.N.; Fielitz J.
Angiotensin II induces skeletal muscle atrophy by activating TFEB-mediated MuRF1 expression
Circulation Research 117 (5): 424-436 (2015-08-14)



Bogomolovas J.; Brohm K.; Celutkiene J.; Balciunaite G.; Bironaite D.; Bukelskiene V.; Daunoravicus D.; Witt C.C.; Fielitz J.; Grabauskiene V.; Labeit S.
Induction of Ankrd1 in dilated cardiomyopathy correlates with the heart failure progression
BioMed Research International 2015: 273936 (2015)



2014

Schmidt F.; Kny M.; Zhu X.; Wollersheim T.; Persicke K.; Langhans C.; Lodka D.; Kleber C.; Weber-Carstens S.; Fielitz J.
The E3 ubiquitin ligase TRIM62 and inflammation-induced skeletal muscle atrophy
Critical Care 18 (5): 545 (2014-09-29)



Langhans C.; Weber-Carstens S.; Schmidt F.; Hamati J.; Kny M.; Zhu X.; Wollersheim T.; Koch S.; Krebs M.; Schulz H.; Lodka D.; Saar K.; Labeit S.; Spies C.; Hubner N.; Spranger J.; Spuler S.; Boschmann M.; Dittmar G.; Butler-Browne G.; Mouly V.; Fielitz J.
Inflammation-induced acute phase response in skeletal muscle and critical illness myopathy
PLoS ONE 9 (3): e92048 (2014-03-20)



Wollersheim T.; Woehlecke J.; Krebs M.; Hamati J.; Lodka D.; Luther-Schroeder A.; Langhans C.; Haas K.; Radtke T.; Kleber C.; Spies C.; Labeit S.; Schuelke M.; Spuler S.; Spranger J.; Weber-Carstens S.; Fielitz J.
Dynamics of myosin degradation in intensive care unit-acquired weakness during severe critical illness
Intensive Care Medicine 40 (4): 528-538 (2014-02-15)



2013

Weber-Carstens S.; Schneider J.; Wollersheim T.; Assmann A.; Bierbrauer J.; Marg A.; Al Hasani H.; Chadt A.; Wenzel K.; Koch S.; Fielitz J.; Kleber C.; Faust K.; Mai K.; Spies C.D.; Luft F.C.; Boschmann M.; Spranger J.; Spuler S.
Critical illness myopathy and GLUT4 - significance of insulin and muscle contraction
American Journal of Respiratory and Critical Care Medicine 187 (4): 387-396 (2013-02-15)



2012

Ferdaoussi M.; Bergeron V.; Zarrouki B.; Kolic J.; Cantley J.; Fielitz J.; Olson E.N.; Prentki M.; Biden T.; Macdonald P.E.; Poitout V.
G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1
Diabetologia 55 (10): 2682-2692 (2012-10)



Bierbrauer J.; Koch S.; Olbricht C.; Hamati J.; Lodka D.; Schneider J.; Luther-Schroeder A.; Kleber C.; Faust K.; Wiesener S.; Spies C.D.; Spranger J.; Spuler S.; Fielitz J.; Weber-Carstens S.
Early type II fiber atrophy in intensive care unit patients with nonexcitable muscle membrane
Critical Care Medicine 40 (2): 647-650 (2012-02)



2011

Biedasek K.; Andres J.; Mai K.; Adams S.; Spuler S.; Fielitz J.; Spranger J.
Skeletal muscle 11beta-HSD1 controls glucocorticoid-induced proteolysis and expression of E3 ubiquitin ligases atrogin-1 and MuRF-1
PLoS ONE 6 (1): e16674 (2011-01-31)



2010

van Rooij E.; Fielitz J.; Sutherland L.B.; Thijssen V.L.; Crijns H.J.; Dimaio M.J.; Shelton J.; De Windt L.J.; Hill J.A.; Olson E.N.
Myocyte enhancer factor 2 and class II histone deacetylases control a gender-specific pathway of cardioprotection mediated by the estrogen receptor
Circulation Research 106 (1): 155-165 (2010-01-08)



2008

Kim M.S.; Fielitz J.; McAnally J.; Shelton J.M.; Lemon D.D.; McKinsey T.A.; Richardson J.A.; Bassel-Duby R.; Olson E.N.
Protein kinase D1 stimulates MEF2 activity in skeletal muscle and enhances muscle performance
Molecular and Cellular Biology 28 (11): 3600-3609 (2008-06)



Fielitz J.; Kim M.S.; Shelton J.M.; Qi X.; Hill J.A.; Richardson J.A.; Bassel-Duby R.; Olson E.N.
Requirement of protein kinase D1 for pathological cardiac remodeling
Proceedings of the National Academy of Sciences of the United States of America 105 (8): 3059-3063 (2008-02-26)



Fliegner D.; Westermann D.; Riad A.; Schubert C.; Becher E.; Fielitz J.; Tschope C.; Regitz-Zagrosek V.
Up-regulation of PPARgamma in myocardial infarction
European Journal of Heart Failure 10 (1): 30-38 (2008-01)



2007

Fielitz J.; Kim M.S.; Shelton J.M.; Latif S.; Spencer J.A.; Glass D.J.; Richardson J.A.; Bassel-Duby R.; Olson E.N.
Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3
Journal of Clinical Investigation 117 (9): 2486-2495 (2007-09)



Montgomery R.L.; Davis C.A.; Potthoff M.J.; Haberland M.; Fielitz J.; Qi X.; Hill J.A.; Richardson J.A.; Olson E.N.
Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility
Genes & Development 21 (14): 1790-1802 (2007-07-15)



Fielitz J.; Philipp S.; Herda L.R.; Schuch E.; Pilz B.; Schubert C.; Gunzler V.; Willenbrock R.; Regitz-Zagrosek V.
Inhibition of prolyl 4-hydroxylase prevents left ventricular remodelling in rats with thoracic aortic banding
European Journal of Heart Failure 9 (4): 336-342 (2007-04)



Fielitz J.; van Rooij E.; Spencer J.A.; Shelton J.M.; Latif S.; van der Nagel R.; Bezprozvannaya S.; de Windt L.; Richardson J.A.; Bassel-Duby R.; Olson E.N.
Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction
Proceedings of the National Academy of Sciences of the United States of America 104 (11): 4377-4382 (2007-03-13)



2006

Philipp S.; Juergensen J.S.; Fielitz J.; Bernhardt W.M.; Weidemann A.; Schiche A.; Pilz B.; Dietz R.; Regitz-Zagrosek V.; Eckardt K.U.; Willenbrock R.
Stabilization of hypoxia inducible factor rather than modulation of collagen metabolism improves cardiac function after acute myocardial infarction in rats
European Journal of Heart Failure 8: 347-354 (2006-06)



2005

Martinka P.; Fielitz J.; Patzak A.; Regitz-Zagrosek V.; Persson P.B.; Stauss H.M.
Mechanisms of blood pressure variability-induced cardiac hypertrophy and dysfunction in mice with impaired baroreflex
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 288 (3): R767-R776 (2005-03)



2004

Fielitz J.; Leuschner M.; Zurbruegg H.R.; Hannack B.; Pregla R.; Hetzer R.; Regitz-Zagrosek V.
Regulation of matrix metalloproteinases and their inhibitors in the left ventricular myocardium of patients with aortic stenosis
Journal of Molecular Medicine 82 (12): 809-820 (2004-12)



Nordmeyer J.; Eder S.; Mahmoodzadeh S.; Martus P.; Fielitz J.; Bass J.; Bethke N.; Zurbruegg H.R.; Pregla R.; Hetzer R.; Regitz-Zagrosek V.
Upregulation of myocardial estrogen receptors in human aortic stenosis
Circulation 110 (20): 3270-3275 (2004-11-16)



Bush E.; Fielitz J.; Melvin L.; Martinez-Arnold M.; McKinsey T.A.; Plichta R.; Olson E.N.
A small molecular activator of cardiac hypertrophy uncovered in a chemical screen for modifiers of the calcineurin signaling pathway
Proceedings of the National Academy of Sciences of the United States of America 101 (9): 2870-2875 (2004-03-02)



2003

Buchhorn R.; Hulpke-Wette M.; Ruschewski W.; Ross R.D.; Fielitz J.; Pregla R.; Hetzer R.; Regitz-Zagrosek V.
Effects of therapeutic beta blockade on myocardial function and cardiac remodelling in congenital cardiac disease
Cardiology In The Young 13 (1): 36-43 (2003-02)



2002

Buchhorn R.; Hulpke-Wette M.; Ruschewski W.; Pregla R.; Fielitz J.; Hetzer R.; Regitz-Zagrosek V.
beta-receptor downregulation in congenital heart disease: a risk factor for complications after surgical repair?
Annals of Thoracic Surgery 73: 610-613 (2002-02-01)



Fielitz J.; Dendorfer A.; Pregla R.; Ehler E.; Zurbruegg H.R.; Bartunek J.; Hetzer R.; Regitz-Zagrosek V.
Neutral endopeptidase is activated in cardiomyocytes in human aortic valve stenosis and heart failure
Circulation 105: 286-289 (2002-01-22)



2001

Fielitz J.; Hein S.; Mitrovic V.; Pregla R.; Zurbruegg H.R.; Warnecke C.; Schaper J.; Fleck E.; Regitz-Zagrosek V.
Activation of the cardiac renin-angiotensin system and increased myocardial collagen expression in human aortic valve disease
Journal of the American College of Cardiology 37 (5): 1443-1449 (2001-04)



2000

Kupfahl C.; Pink D.; Friedrich K.; Zurbruegg H.R.; Neuss M.; Warnecke C.; Fielitz J.; Graf K.; Fleck E.; Regitz-Zagrosek V.
Angiotensin II directly increases transforming growth factor beta1 and osteopontin and indirectly affects collagen mRNA expression in the human heart
Cardiovascular Research 46 (3): 463-475 (2000-06)



1998

Regitz-Zagrosek V.; Fielitz J.; Fleck E.
Myocardial angiotensin receptors in human hearts
Basic Research in Cardiology 93 Suppl 2: 37-42 (1998)



1997

Regitz-Zagrosek V.; Fielitz J.; Dreysse R.; Hildebrandt A.G.; Fleck E.
Angiotensin receptor type 1 mRNA in human right ventricular endomyocardial biopsies: downregulation in heart failure
Cardiovascular Research 35 (1): 99-105 (1997-07)



1996

Regitz-Zagrosek V.; Fielitz J.; Hummel M.; Hildebrandt A.G.; Hetzer R.; Fleck E.
Decreased expression of ventricular angiotensin receptor type 1 mRNA after human heart transplantation
Journal of Molecular Medicine 74 (12): 777-782 (1996-12)