Ferdinand le Noble

Max-Delbrück-Center for Molecular Medicine (MDC)

Angiogenesis and Cardiovascular Pathology

Robert-Rössle-Str. 10

13125 Berlin, Germany

Phone: +49 30 9406 3892/4

FAX: +49 30 9406 3850

lenoble@mdc-berlin.de

 

 

Research Fields

- regulation of vascular development, angiogeneis - arteriogenesis

- adaptive vascular remodeling in ischemic cardiovascular disease

- mechanotransduction, hemodynamics and vascular network formation

 

Education & Professional experience

Associate Professor (W2) | Charité Universitätsmedizin and Junior Group Leader | MDC, Berlin

2006 - present

 

Visiting Scientist | INSERM U36

2003-2005 College de France, Paris, France

 

Assistant Professor | University of Maastricht, Netherlands

1998-2003 Dept. of Physiology, CARIM

 

Postdoctoral training | University of Maastricht, Netherlands

1997-1998 Dept. of Pediatrics, AZM-University Hospital

 

Doctoral Training | University of Maastricht, Netherlands

1991-1997 Dept. of Pharmacology

 

Undergraduate Training | University of Maastricht, Netherlands

1986-1991 Human Biology

 

Publications

Selected (2004-2011)

Hillmeister P*, Gatzke N*, Dulsner A, Bader M, Schadock I, Hoefer I, Hamann L, Infante-Duarte C, Jung G, Troidl K, Urban D, Stawowy P, Frentsch M, Li M, Nagorka S, Wang H, Shi Y, Le Noble F*, Buschmann I* (2011). Arteriogenesis is modulated by bradykinin receptor signaling. Circulation Research 109, 524-533. *equal contribution

 

Klein C, Mikutta J, Krueger J, Scholz K, Brinkmann J, Liu D, Veerkamp J, Siegel D, Abdelilah-Seyfried S, Le Noble F (2011). Neuron navigator 3a regulates liver organogenesis during zebrafish embryogenesis. Development 138, 1935-1945.

 

Krueger J, Liu D, Scholz K, Zimmer A, Shi Y, Klein C, Siekmann A, Schulte-Merker S, Cudmore M, Ahmed A, Le Noble F (2011). Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo. Development 138, 2111-2120.

 

Buschmann I, Pries A, Styp-Rekowska B, Hillmeister P, Loufrani L, Henrion D, Shi Y, Duelsner A, Hoefer I, Gatzke N, Wang H, Lehmann K, Ulm L, Ritter Z, Hauff P, Hlushchuk R, Djonov V, van Veen T, Le Noble F (2010). Pulsatile shear and Gja5 modulate arterial identity and remodeling events during flow-driven arteriogenesis. Development 137, 2187-2196.

 

Lu X*, Le Noble F*, Yuan L, Jiang Q, De Lafarge B, Sugiyama D, Breant C, Claes F, De Smet F, Thomas JL, Autiero M, Carmeliet P, Tessier-Lavigne M, Eichmann A (2004). The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 432, 179-186. *equal contribution

 

Teaching

  • Currently supervising 3 PhD students (2graduated 2006 – 2007)

 

MDC PhD lecture series