Welcome to the German-Israeli Helmholtz Research School "Frontiers in Cell Signaling and Gene Regulation" (SignGene)

Launched in 2013, SignGene is an international exchange program for PhD students in biomedical sciences. Based at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) in Berlin, our partners include the Hebrew University of Jerusalem (HUJI) and the Technion – Israel Institute of Technology (TEC) in Haifa, as well as the Humboldt Universität zu Berlin and the Charité-Universitätsmedizin in Berlin.

SignGene offers a unique international scientific training environment with a focus on cell signaling, gene regulation, and quantitative biology relevant to normal cellular functions as well as the development and progression of diseases such as cancer. We currently have 36 faculty members, 20 of whom are located in Germany and 16 in Israel. Lively interactions within our scientific community and vivid collaborations across borders make SignGene an exceptional international experience for PhD students.


We will accept up to 25 doctoral students who will have one of our partnering institutions in Germany or Israel as a home institute. Currently, eight students are located in Berlin, four students in Haifa, and five in Jerusalem.

All students work on collaborative research projects jointly supervised by the principle investigator at their home institute and a partnering group leader from abroad. The main location of a student is defined by the main supervisor's affiliation. As an essential part of the training, SignGene students spend around 6 months of their PhD in the partnering co-mentor's lab in the other country.


September 2017
Nir Friedman and Yaakov Nahmias receive award
The Rosetrees Trust Interdisciplinary Prize has been awarded to Nir Friedman and Yaakov Nahmias, SignGene faculty at Hebrew University, for a bold new model of human metabolism. For more information, please read here.

March 2017
SignGene Winter School in Eilat
This year's SignGene Winter School "Cellular Biology Through the Proteome and Single Cell Methods" took place in Eilat, Israel and included a visit to Petra in Jordan. Read more here.

June 2016
Nagarjuna R. Pamudurti receives JBC Fellowship
SignGene PhD student Nagarjuna Reddy Pamudurti has been awarded the JBC Doctoral Gold Fellowship by the Jerusalem Brain Community for his proposal: "Biogenesis and Function of circRNAs". Nagarjuna works on his PhD thesis in Sebastian Kadener's lab at the Hebrew University of Jerusalem (HUJI), in collaboration with Nikolaus Rajewsky at the MDC. For more information, please click here.

June 2016
Ulrike Stein is elected to MRS Board
MDC group leader and SignGene faculty member Ulrike Stein has been elected to the Board of the Metastasis Research Society (MRS).For more information, please click here

May 2016
Nir Friedman receives Humboldt Research Award
Israeli systems biologist, bioinformatician and SignGene faculty member Nir Friedman of the Hebrew University of Jerusalem (HUJI) is one of this year’s recipients of the prestigious Humboldt Research Award. For more information click here.

March 2016
Yinon Ben-Neriah receives Rappaport Prize
The 2016 Rappaport Prize goes to Yinon Ben-Neriah, a SignGene faculty member from the Hebrew University of Jerusalem. For more information click here.



Dr. Sandra Krull
Max Delbrück Center for Molecular Medicine
Robert-Rössle-Str 10
13125 Berlin

Phone: +49 30 9406 4205
Fax: +49 30 9406 2170