Class of 2017

 

Patrick Mucka

Mechanisms of posttranscriptional gene regulation by IkB kinases

Lab of Claus Scheidereit, Max Delbrück Center for Molecular Medicine

Co-Mentor: Ze'ev Ronai, Technion - Israel Institute of Technology



    Hazel Quinn

    The Role of Sonic-Hedgehog in the Development of Wnt-Met Driven Basal-Like        

    Breast Cancer

 

     Lab of Walter Birchmeier, Max Delbrück Center for Molecular Medicine

                        Co-mentor: Yaron Fuchs, Technion - Israel Institute of Technology



Class of 2016

 

Alba Ferri Blázquez

Molecular analysis of Ubiquitin modifications on Serine/Threonine residues

 

Lab of Thomas Sommer, Max Delbrück Center for Molecular Medicine

Co-mentors: Michael Glickman & Aaron Ciechanover, Technion - Israel Institute of Technology


 

Eric Hung

CKI as a therapy target in the haematopoiesis malignancies

 

Lab of Yinon Ben-Neriah, Hebrew University of Jerusalem

Co-mentors: Klaus Rajewsky, Max Delbrück Center for Molecular Medicine & Clemens Schmitt, Charité Universitätsmedizin

 

 

Class of 2015

 

Alon Appleboim

A systematic approach to RNA effects on cellular localization

 

Lab of Nir Friedman, Hebrew University of Jerusalem

Co-mentor: Nikolaus Rajewsky, Max Delbrück Center for Molecular Medicine


Publications

Weiner A, Hsieh TH, Appleboim A, Chen HV, Rahat A, Amit I, Rando OJ, Friedman N (2015). High-resolution chromatin dynamics during a yeast stress response. Mol. Cell 58, 1-16

Geffen Y, Appleboim A, Gardner RG, Friedman N, Sadeh R, Ravid T. Mapping the Landscape of a Eukaryotic Degronome (2016). Mol. Cell 63(6), 1055-65

 

 

 

Nagarjuna Reddy Pamudurti

Biogenesis and function of circRNAs in Drosophila

 

Lab of Sebastian Kadener, Hebrew University of Jerusalem

Co-mentor: Nikolaus Rajewsky, Max Delbrück Center for Molecular Medicine


Publications

Ashwal-Fluss R*, Meyer M*, Pamudurti NR*, Ivanov A, Bartok O, Hanan M, Evantal N, Memczak S, Rajewsky N, Kadener S (2014). circRNA biogenesis competes with pre-mRNA splicing. Mol. Cell 46, 55-56

*equal contribution

Pamudurti NR*, Bartok O*, Jens M*, Ashwal-Fluss R*, Stottmeister C, Ruhe L, Hanan M, Wyler E, Perez-Hernandez D, Ramberger E, Shenzis S, Samson M, Dittmar G, Landthaler M, Chekulaeva M, Rajewsky N, Kadener S (2017). Translation of CircRNAs. Mol. Cell 66(1), 9-21

*equal contribution

 

 

Yana Rozevsky

Single-molecule quantification of the cancer biomarkers KRAS, MACC1 and S100A4 using solid-state nanopores

 

Lab of Amit Meller, Technion - Israel Institute of Technology

Co-mentor: Ulrike Stein, Charité - Universitätsmedizin / Max Delbrück Center for Molecular Medicine




Class of 2014

 

Dhana Friedrich

Oscillatory transcription factors and stochastic gene expression

 

Lab of Alexander Loewer, Max Delbrück Center for Molecular Medicine

Co-mentor: Amit Meller, Technion - Israel Institute of Technology


 

Christian Lips

Characterization of membrane-associated ubiquitin ligases

 

Lab of Thomas Sommer, Max Delbrück Center for Molecular Medicine

Co-mentors: Michael Glickman/Aaron Ciechanover, Technion - Israel Institute of Technology


 

Waleed Minzel

Regulation of quiescence entry and exit of hematopoietic stem cells

 

Lab of Yinon Ben-Neriah, Hebrew University of Jerusalem

Co-mentor: Clemens Schmitt, Charité - Universitätsmedizin Berlin


Publications

Haddad A, Flint-Ashtamker G, Minzel W, Sood R, Rimon G, Barki-Harrington L (2012). Prostaglandin EP1 receptor down-regulates expression of cyclooxygenase-2 by facilitating its proteasomal degradation. J. Biol. Chem. 287(21), 17214-17223

Sood R, Minzel W, Rimon G, Tal S, Barki-Harrington L (2014). Down-regulation of cyclooxygenase-2 by the carboxyl tail of the angiotensin II type 1 receptor. J. Biol. Chem. 289(45), 31473-31479



 

 

 

Simon Prisner

Molecular mechanisms of viral infection

 

Lab of Andreas Herrmann, Humboldt-Universität zu Berlin

Co-mentor: Amit Meller, Technion - Israel Institute of Technology


Publications

Jin S, Kedia N, Illes-Toth E, Haralampiev I, Prisner S, Herrmann A, Wanker EE, Bieschke J (2016). Amyloid-β(1-42) Aggregation Initiates Its Cellular Uptake and Cytotoxicity. J Biol Chem. 291(37), 19590-606

 

 

Christin Stottmeister

Exploring circRNA functions in Neuronal Differentiation and Disease

 

Lab of Nikolaus Rajewsky, Max Delbrück Center for Molecular Medicine

Co-mentor: Sebastian Kadener, Hebrew University of Jerusalem


Publications

Rybak-Wolf, A*, Stottmeister, C*, Glažar, P*, Jens, M, Pino, N, Giusti, S, Hanan, M, Behm, M, Bartok,  O, Ashwal-Fluss, R, ..., Kadener S, Rajewsky, N (2015). Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. Mol. Cell 1–16.

*equal contribution




 

Jane Joy Thomas

Role of RNF4 in oncogene activation

 

Lab of Amir Orian, Technion - Israel Institute of Technology

Co-mentor: Walter Birchmeier, Max Delbrück Center for Molecular Medicine


Publications

Thomas JJ, Rekha Chandra MR, Sharma P (2010). Dextran glycidyltrimethylammonium chloride conjugate/DNA nanoplex: A potential non-viral and haemocompatible gene delivery system. Int. Journal of Pharmaceutics 389(1-2), 195-206

Thomas JJ, Rekha Chandra MR, Sharma P (2010). Unraveling the intracellular efficacy of Dextran-Histidine Polycation as an efficient non-viral gene delivery system. Mol. Pharmaceutics (ACS) 9(1), 121-134

Thomas JJ, Rekha Chandra MR, Sharma P (2012). Dextran-protamine polycation: An efficient nonviral and haemocompatible gene delivery system. Colloids and Surfaces B: Biosurfaces 81(1), 195-205

Thomas JJ, Abed M, Heuberger J, Novak R, Zohar Y, Beltran Lopez AP, Trausch-Azar JS, Ilagan MX, Benhamou D, Dittmar G, Kopan R, Birchmeier W, Schwartz AL, Orian A (2016). RNF4-Dependent Oncogene Activation by Protein Stabilization. Cell Rep. 16(12), 3388-400

 

Class of 2013

 

Dámaris Anell Rendon

Proteotoxicity in therapy-induced senescence

 

Lab of Clemens Schmitt, Max Delbrück Center for Molecular Medicine / Charité Virchow Klinikum MKFZ

Co-mentor: Michael Glickman, Technion - Israel Institute of Technology


Publications

Bouzas-Rodríguez J, Zárraga-Granados G, Sánchez-Carbente MdR, Rodríguez-Valentín R, Gracida X, Anell-Rendón D, Covarrubias L, Castro-Obregón S (2012). The nuclear receptor NR4A1 induces a form of cell death dependent on autophagy in mammalian cells. PLoS ONE 7(10), e46422

 

 

Upasana Das Adhikari

p53 control of intestinal stem cell fate

 

Lab of Yinon Ben-Neriah, Hebrew University of Jerusalem

Co-mentors: Walter Birchmeier and Alexander Loewer, Max Delbrück Center for Molecular Medicine

 

 

Naama Flint Brodsly

Elucidating a genetic network that maintains the differentiated identity of enterocytes and gut homeostasis

 

Lab of Amir Orian, Technion - Israel Institute of Technology

Co-mentor: Walter Birchmeier, Max Delbrück Center for Molecular Medicine

 

 

 

Inbal Ipenberg

Mechanisms of signal-dependent activation of NF-kappaB precursor complexes

 

Lab of Claus Scheidereit, Max Delbrück Center for Molecular Medicine

Co-mentor: Aaron Ciechanover, Technion - Israel Institute of Technology


Publications

Ipenberg I, Guttmann-Raviv N, Khoury HP, Kupershmit I, Ayoub N (2013). Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase. J. Biol. Chem. 288(21), 14681-14687

Yilmaz ZB, Kofahl B, Beaudette P, Baum K, Ipenberg I, Weih F, Wolf J, Dittmar G, Scheidereit C (2014). Quantitative dissection and modeling of the NF-kB p100-p105 module reveals interdependent precursor proteolysis. Cell Reports 9(5), 1756-1769

Khoury-Haddad H, Guttmann-Raviv N, Ipenberg I, Huggins D, Jeyasekharan AD, Ayoub N (2014). PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. Proc. Natl. Acad. Sci. U S A 111(7), E728-737

 

 

 

Class of 2012

 

Juliane Brümmer

Rho GTPase signaling downstream of guidance receptors

 

Lab of Oliver Rocks, Max Delbrück Center for Molecular Medicine

Co-mentor: Gera Neufeld, Technion - Israel Institute of Technology

 

 

Undine Hill

Epigenetic functions of the transcription factor CEBP/alpha

 

Lab of Achim Leutz, Max Delbrück Center for Molecular Medicine

Co-mentor: Amir Orian, Technion - Israel Institute of Technology


Publications

Bledau AD, Schmidt K, Neumann K, Hill U, Ciotta G, Gupta A, Torres DC, Fu J, Kranz A, Stewart AF, Anastassiadis K (2014). The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation. Development 141(5), 1022-1035

 

 

 

Alumni

 

Shari Orlanski

 

Lab of Yehudit Bergman, Hebrew University of Jerusalem

Co-mentors: Klaus Rajewsky and Martin Janz, Max Delbrück Center for Molecular Medicine


Publications

Penaloza C, Orlanski S, Ye Y, Entezari-Zaher T, Javdan M, Zakeri Z (2008). Cell death in mammalian development. Curr. Pharm. Des. 14(2), 184-196

Penaloza C, Estevez B, Orlanski S, Sikorska M, Walker R, Smith C, Smith B, Lockshin RA, Zakeri Z (2009). Sex of the cell dictates its response: differential gene expression and sensitivity to cell death inducing stress in male and female cells. FASEB J 23(6), 1869-1879

Orlanski S, Bergman Y (2012). Chapter 12: MicroRNAs in embryonic stem cells. In Appasani K (Ed.), Epigenomics: From chromatin biology to therapeutics (pp 163-178) Gene Expression Systems, Inc. ISBN: 9781139533997

Ludwig G, Nejman D, Hecht M, Orlanski S, Abu-Remaileh M, Yanuka O, Sandler O, Marx A, Roberts D, Benvenisty N, Bergman Y, Mendelsohn M, Cedar H (2014). Aberrant DNA methylation in ES cells. PloS One 9(5), e96090

Popowski M, Templeton TD, Lee BK, Rhee C, Li H, Miner C, Dekker JD, Orlanski S, Bergman Y, Iyer VR, Webb CF, Tucker H (2014). Bright/Arid3A acts as a barrier to somatic cell reprogramming through direct regulation of Oct4, Sox2, and Nanog. Stem Cell Reports 2(1), 26-35

Orlanski S, Labi V, Reizel Y, Spiro A, Lichtenstein M, Levin-Klein R, Koralov SB, Skversky Y, Rajewsky K, Cedar H, Bergman Y (2016). Tissue-specific DNA demethylation is required for proper B-cell differentiation and function. Proc Natl Acad Sci U S A 113(18), 5018-23

 

 

Sylvia Zérath Gurevich

Biology and proteomics of the small protein modifier, Rub1

 

Lab of Michael Glickman, Technion - Israel Institute of Technology

Co-mentors: Gunnar Dittmar and Thomas Sommer, Max Delbrück Center for Molecular Medicine


Publications

Singh RK, Zérath S, Kleifeld O, Scheffner M, Glickman MH, Fushman D (2012). Recognition and cleavage of related to ubiquitin (Rub1) and Rub1-ubiquitin chains by components of the ubiquitin-proteasome system. Mol. Cell. Proteomics 11(12), 1595-1611

News

September 2017
Nir Friedman and Yaakov Nahmias receive award
The Rosetrees Trust Interdisciplinary Prize has been awarded to Nir Friedman and Yaakov Nahmias, SignGene faculty at Hebrew University, for a bold new model of human metabolism. For more information, please read here.


March 2017
SignGene Winter School in Eilat
This year's SignGene Winter School "Cellular Biology Through the Proteome and Single Cell Methods" took place in Eilat, Israel and included a visit to Petra in Jordan. Read more here.

June 2016
Nagarjuna R. Pamudurti receives JBC Fellowship
SignGene PhD student Nagarjuna Reddy Pamudurti has been awarded the JBC Doctoral Gold Fellowship by the Jerusalem Brain Community for his proposal: "Biogenesis and Function of circRNAs". Nagarjuna works on his PhD thesis in Sebastian Kadener's lab at the Hebrew University of Jerusalem (HUJI), in collaboration with Nikolaus Rajewsky at the MDC. For more information, please click here.


June 2016
Ulrike Stein is elected to MRS Board
MDC group leader and SignGene faculty member Ulrike Stein has been elected to the Board of the Metastasis Research Society (MRS).For more information, please click here


May 2016
Nir Friedman receives Humboldt Research Award
Israeli systems biologist, bioinformatician and SignGene faculty member Nir Friedman of the Hebrew University of Jerusalem (HUJI) is one of this year’s recipients of the prestigious Humboldt Research Award. For more information click here.


March 2016
Yinon Ben-Neriah receives Rappaport Prize
The 2016 Rappaport Prize goes to Yinon Ben-Neriah, a SignGene faculty member from the Hebrew University of Jerusalem. For more information click here.

 


Contact

Dr. Sandra Krull
Max Delbrück Center for Molecular Medicine
Robert-Rössle-Str 10
13125 Berlin
Germany

Phone: +49 30 9406 4205
Fax: +49 30 9406 2170
signgene@mdc-berlin.de