Publications



2018

Jadasz J.J.; Tepe L.; Beyer F.; Samper Agrelo I.; Akkermann R.; Spitzhorn L.S.; Silva M.E.; Oreffo R.O.C.; Hartung H.P.; Prigione A.; Rivera F.J.; Adjaye J.; Kuery P.
Human mesenchymal factors induce rat hippocampal- and human neural stem cell dependent oligodendrogenesis
Glia 66 (1): 145-160 (2018-01)



2017

Scior A.; Buntru A.; Arnsburg K.; Ast A.; Iburg M.; Juenemann K.; Pigazzini M.L.; Mlody B.; Puchkov D.; Priller J.; Wanker E.E.; Prigione A.; Kirstein J.
Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex
EMBO Journal : e201797212 (2017-12-06)



Inak G.; Lorenz C.; Lisowski P.; Zink A.; Mlody B.; Prigione A.
Concise review: Induced pluripotent stem cell-based drug discovery for mitochondrial disease
Stem Cells 35 (7): 1655-1662 (2017-07)



Lorenz C.; Lesimple P.; Bukowiecki R.; Zink A.; Inak G.; Mlody B.; Singh M.; Semtner M.; Mah N.; Aure K.; Leong M.; Zabiegalov O.; Lyras E.M.; Pfiffer V.; Fauler B.; Eichhorst J.; Wiesner B.; Huebner N.; Priller J.; Mielke T.; Meierhofer D.; Izsvak Z.; Meier J.C.; Bouillaud F.; Adjaye J.; Schuelke M.; Wanker E.E.; Lombes A.; Prigione A.
Human iPSC-derived neural progenitors are an effective drug discovery model for neurological mtDNA disorders
Cell Stem Cell 20 (5): 659-674.e9 (2017-05-04)



2016

Schottmann G.; Sarpong A.; Lorenz C.; Weinhold N.; Gill E.; Teschner L.; Ferdinandusse S.; Wanders R.J.A.; Prigione A.; Schuelke M.
A movement disorder with dystonia and ataxia caused by a mutation in the HIBCH gene
Movement Disorders 31 (11): 1733-1739 (2016-11)



Mlody B.; Prigione A.
A glycolytic solution for pluripotent stem cells
Cell Stem Cell 19 (4): 419-420 (2016-10-06)



Lorenz C.; Prigione A.
Aging vs. rejuvenation: reprogramming to iPSCs does not turn back the clock for somatic mitochondrial DNA mutations
Stem Cell Investigation 3: 43 (2016-09)



Prigione A.
A mitochondrial view of cell fate
Seminars in Cell & Developmental Biology 52: 66-67 (2016-04)



Wang J.; Singh M.; Sun C.; Besser D.; Prigione A.; Ivics Z.; Hurst L.D.; Izsvak Z.
Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression
Nature Protocols 11 (2): 327-346 (2016-02)



2015

Rohwer N.; Bindel F.; Grimm C.; Lin S.J.; Wappler J.; Klinger B.; Bluethgen N.; Du Bois I.; Schmeck B.; Lehrach H.; de Graauw M.; Goncalves E.; Saez-Rodriguez J.; Tan P.; Grabsch H.I.; Prigione A.; Kempa S.; Cramer T.
Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A
Oncotarget 7 (6): 6693-6710 (2015-12-29)



Stincone A.; Prigione A.; Cramer T.; Wamelink M.M.C.; Campbell K.; Cheung E.; Olin-Sandoval V.; Gruening N.M.; Krueger A.; Tauqeer Alam M.; Keller M.A.; Breitenbach M.; Brindle K.M.; Rabinowitz J.D.; Ralser M.
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
Biological Reviews 90 (3): 927-963 (2015-08)



Prigione A.; Ruiz-Perez M.V.; Bukowiecki R.; Adjaye J.
Metabolic restructuring and cell fate conversion
Cellular and Molecular Life Sciences 72 (9): 1759-1777 (2015-05-01)



Hossini A.M.; Megges M.; Prigione A.; Lichtner B.; Toliat M.R.; Wruck W.; Schroeter F.; Nuernberg P.; Kroll H.; Makrantonaki E.; Zoubouliss C.C.; Adjaye J.
Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks
BMC Genomics 16 (1): 84 (2015-02-14)



Prigione A.
Induced pluripotent stem cells (iPSCs) for modeling mitochondrial DNA disorders
Methods in Molecular Biology 1265: 349-356 (2015-01-06)



Pfiffer V.; Prigione A.
Assessing the bioenergetic profile of human pluripotent stem cells
Methods in Molecular Biology 1264: 279-288 (2015)



2014

Wang J.; Xie G.; Singh M.; Ghanbarian A.T.; Rasko T.; Szvetnik A.; Cai H.; Besser D.; Prigione A.; Fuchs N.V.; Schumann G.G.; Chen W.; Lorincz M.C.; Ivics Z.; Hurst L.D.; Izsvak Z.
Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells
Nature 516 (7531): 405-409 (2014-12-18)



Prigione A.; Adjaye J.
A mitochondrial strategy for safeguarding the reprogrammed genome
Cell Regeneration 3 (1): 5 (2014-03-29)



Prigione A.; Rohwer N.; Hoffman S.; Mlody B.; Drews K.; Bukowiecki R.; Bluemlein K.; Wanker E.E.; Ralser M.; Cramer T.; Adjaye J.
HIF1{alpha} modulates reprogramming through early glycolytic shift and up-regulation of PDK1-3 and PKM2
Stem Cells 32 (2): 364-376 (2014-02)



Bukowiecki R.; Adjaye J.; Prigione A.
Mitochondrial function in pluripotent stem cells and cellular reprogramming
Gerontology 60 (2): 174-182 (2014-02)



2013

Stachelscheid H.; Wulf-Goldenberg A.; Eckert K.; Jensen J.; Edsbagge J.; Bjoerquist P.; Rivero M.; Strehl R.; Jozefczuk J.; Prigione A.; Adjaye J.; Urbaniak T.; Bussmann P.; Zeilinger K.; Gerlach J.C.
Teratoma formation of human embryonic stem cells in three-dimensional perfusion culture bioreactors
Journal of Tissue Engineering and Regenerative Medicine 7 (9): 729-741 (2013-09)



Vigone G.; Merico V.; Prigione A.; Mulas F.; Sacchi L.; Gabetta M.; Bellazzi R.; Redi C.A.; Mazzini G.; Adjaye J.; Garagna S.; Zuccotti M.
Transcriptome based identification of mouse cumulus cell markers that predict the developmental competence of their enclosed antral oocytes
BMC Genomics 14: 380 (2013-06-07)



Al-Nbaheen M.; Vishnubalaji R.; Ali D.; Bouslimi A.; Al-Jassir F.; Megges M.; Prigione A.; Adjaye J.; Kassem M.; Aldahmash A.
Human stromal (mesenchymal) stem cells from bone marrow, adipose tissue and skin exhibit differences in molecular phenotype and differentiation potential
Stem Cell Reviews and Reports 9 (1): 32-43 (2013-02)



2012

Drews K.; Jozefczuk J.; Prigione A.; Adjaye J.
Human induced pluripotent stem cells--from mechanisms to clinical applications
Journal of Molecular Medicine 90 (7): 735-745 (2012-07)



Zuccotti M.; Merico V.; Belli M.; Mulas F.; Sacchi L.; Zupan B.; Redi C.A.; Prigione A.; Adjaye J.; Bellazzi R.; Garagna S.
OCT4 and the acquisition of oocyte developmental competence during folliculogenesis
International Journal of Developmental Biology 56 (10-12): 853-858 (2012)



2011

Prigione A.; Hossini A.M.; Lichtner B.; Serin A.; Fauler B.; Megges M.; Lurz R.; Lehrach H.; Makrantonaki E.; Zouboulis C.C; Adjaye J.
Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations
PLoS ONE 6 (11): e27352 (2011-11-14)



Prigione A.; Lichtner B.; Kuhl H.; Struys E.A.; Wamelink M.; Lehrach H.; Ralser M.; Timmermann B.; Adjaye J.
Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming
Stem Cells 29 (9): 1338-1348 (2011-09)



Mah N.; Wang Y.; Liao M.C.; Prigione A.; Jozefczuk J.; Lichtner B.; Wolfrum K.; Haltmeier M.; Floettmann M.; Schaefer M.; Hahn A.; Mrowka R.; Klipp E.; Andrade-Navarro M.A.; Adjaye J.
Molecular insights into reprogramming-initiation events mediated by the OSKM gene regulatory network
PLoS ONE 6 (8): e24351 (2011-08-31)



Zuccotti M.; Merico V.; Bellone M.; Mulas F.; Sacchi L.; Rebuzzini P.; Prigione A.; Redi C.A.; Bellazzi R.; Adjaye J.; Garagna S.
Gatekeeper of pluripotency: a common Oct4 transcriptional network operates in mouse eggs and embryonic stem cells
BMC Genomics 12: 345 (2011-07-05)



Jozefczuk J.; Prigione A.; Chavez L.; Adjaye J.
Comparative analysis of human embryonic stem cell and induced pluripotent stem cell-derived hepatocyte-like cells reveals current drawbacks and possible strategies for improved differentiation
Stem Cells and Development 20 (7): 1259-1275 (2011-07)



Krueger R.; Sharma M.; Riess O.; Gasser T.; Van Broeckhoven C.; Theuns J.; Aasly J.; Annesi G.; Bentivoglio A.R.; Brice A.; Djarmati A.; Elbaz A.; Farrer M.; Ferrarese C.; Gibson J.M.; Hadjigeorgiou G.M.; Hattori N.; Ioannidis J.P.A.; Jasinska-Myga B.; Klein C.; Lambert J.C.; Lesage S.; Lin J.J.; Lynch T.; Mellick G.D.; de Nigris F.; Opala G.; Prigione A.; Quattrone A.; Ross O.A.; Satake W.; Silburn P.A.; Tan E.K.; Toda T.; Tomiyama H.; Wirdefeldt K.; Wszolek Z.; Xiromerisiou G.; Maraganore D.M.
A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease
Neurobiology of Aging 32 (3): 548.e9-548.e18 (2011-03)



2010

Di Stefano B.; Buecker C.; Ungaro F.; Prigione A.; Chen H.H.; Welling M.; Eijpe M.; Mostoslavsky G.; Tesar P.; Adjaye J.; Geijsen N.; Broccoli V.
An ES-like pluripotent state in FGF-dependent murine iPS cells
PLoS ONE 5 (12): e16092 (2010-12-30)



Wolfrum K.; Wang Y.; Prigione A.; Sperling K.; Lehrach H.; Adjaye J.
The LARGE principle of cellular reprogramming: lost, acquired and retained gene expression in foreskin and amniotic fluid-derived human iPS cells
PLoS ONE 5 (10): e13703 (2010-10-29)



Prigione A.; Piazza F.; Brighina L.; Begni B.; Galbussera A.; DiFrancesco J.C.; Andreoni S.; Piolti R.; Ferrarese C.
Alpha-synuclein nitration and autophagy response are induced in peripheral blood cells from patients with Parkinson disease
Neuroscience Letters 477 (1): 6-10 (2010-06-14)



Wang Y.; Mah N.; Prigione A.; Wolfrum K.; Andrade-Navarro M.A.; Adjaye J.
A transcriptional roadmap to the induction of pluripotency in somatic cells
Stem Cell Reviews 6 (2): 282-296 (2010-06)



Brighina L.; Prigione A.; Begni B.; Galbussera A.; Andreoni S.; Piolti R.; Ferrarese C.
Lymphomonocyte alpha-synuclein levels in aging and in Parkinson disease
Neurobiology of Aging 31 (5): 884-885 (2010-05)



Prigione A.; Fauler B.; Lurz R.; Lehrach H.; Adjaye J.
The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells
Stem Cells 28 (4): 721-733 (2010-04)



Prigione A.; Adjaye J.
Modulation of mitochondrial biogenesis and bioenergetic metabolism upon in vitro and in vivo differentiation of human ES and iPS cells
International Journal of Developmental Biology 54 (11-12): 1729-1741 (2010)



2009

Di Stefano B.; Prigione A.; Broccoli V.
Efficient genetic reprogramming of unmodified somatic neural progenitors uncovers the essential requirement of Oct4 and Klf4
Stem Cells and Development 18 (5): 707-716 (2009-06)



Prigione A.; Isaias I.U.; Galbussera A.; Brighina L.; Begni B.; Andreoni S.; Pezzoli G.; Antonini A.; Ferrarese C.
Increased oxidative stress in lymphocytes from untreated Parkinson's disease patients
Parkinsonism & Related Disorders 15 (4): 327-328 (2009-05)



2007

Prigione A.; Cortopassi G.
Mitochondrial DNA deletions induce the adenosine monophosphate-activated protein kinase energy stress pathway and result in decreased secretion of some proteins
Aging Cell 6 (5): 619-630 (2007-10)



Prigione A.; Cortopassi G.
Mitochondrial DNA deletions and chloramphenicol treatment stimulate the autophagic transcript ATG12
Autophagy 3 (4): 377-380 (2007-07)



Alemi M.; Prigione A.; Wong A.; Schoenfeld R.; DiMauro S.; Hirano M.; Taroni F.; Cortopassi G.
Mitochondrial DNA deletions inhibit proteasomal activity and stimulate an autophagic transcript
Free Radical Biology and Medicine 42 (1): 32-43 (2007-01-01)



2006

Prigione A.; Begni B.; Galbussera A.; Beretta S.; Brighina L.; Garofalo R.; Andreoni S.; Piolti R.; Ferrarese C.
Oxidative stress in peripheral blood mononuclear cells from patients with Parkinson's disease: negative correlation with levodopa dosage
Neurobiology of Disease 23 (1): 36-43 (2006-07)



2004

Bizzozero I.; Lucchelli F.; Prigione A.; Saetti M.C.; Spinnler H.
"What do you remember about Chernobyl?" A new test of memory for media-mediated events
Neurological Sciences 25 (4): 205-215 (2004-10)