Publications



2017

Boege Y.; Malehmir M.; Healy M.E.; Bettermann K.; Lorentzen A.; Vucur M.; Ahuja A.K.; Boehm F.; Mertens J.C.; Shimizu Y.; Frick L.; Remouchamps C.; Mutreja K.; Kaehne T.; Sundaravinayagam D.; Wolf M.J.; Rehrauer H.; Koppe C.; Speicher T.; Padrissa-Altes S.; Maire R.; Schattenberg J.M.; Jeong J.S.; Liu Lei; Zwirner S.; Boger R.; Hueser N.; Davis R.J.; Muellhaupt B.; Moch H.; Schulze-Bergkamen H.; Clavien P.A.; Werner S.; Borsig L.; Luther S.A.; Jost P.J.; Weinlich R.; Unger K.; Behrens A.; Hillert L.; Dillon C.; Di Virgilio M.; Wallach D.; Dejardin E.; Zender L.; Naumann M.; Walczak H.; Green D.R.; Lopes M.; Lavrik I.; Luedde T.; Heikenwalder M.; Weber A.
A dual role of Caspase-8 in triggering and sensing proliferation-associated DNA damage, a key determinant of liver cancer development
Cancer Cell 32 (3): 342-359.e10 (2017-09-11)



Rahjouei A.; Pirouz M.; Di Virgilio M.; Kamin D.; Kessel M.
MAD2L2 promotes open chromatin in embryonic stem cells and derepresses the Dppa3 locus
Stem Cell Reports 8 (4): 813-821 (2017-04-11)



2015

Volk T.; Pannicke U.; Reisli I.; Bulashevska A.; Ritter J.; Bjoerkman A.; Schaeffer A.A.; Fliegauf M.; Sayar E.H.; Salzer U.; Fisch P.; Pfeifer D.; Di Virgilio M.; Cao H.; Yang F.; Zimmermann K.; Keles S.; Caliskaner Z.; Guener S.; Schindler D.; Hammarstroem L.; Rizzi M.; Hummel M.; Pan-Hammarstroem Q.; Schwarz K.; Grimbacher B.
DCLRE1C (ARTEMIS) mutations causing phenotypes ranging from atypical severe combined immunodeficiency to mere antibody deficiency
Human Molecular Genetics 24 (25): 7361-7372 (2015-12-20)



Sander S.; Chu V.T.; Yasuda T.; Franklin A.; Graf R.; Calado D.P.; Li S.; Imami K.; Selbach M.; Di Virgilio M.; Bullinger L.; Rajewsky K.
PI3 kinase and FOXO1 transcription factor activity differentially control B cells in the germinal center light and dark zones
Immunity 43 (6): 1075-1086 (2015-12-15)



Kracker S.; Di Virgilio M.; Schwartzentruber J.; Cuenin C.; Forveille M.; Deau M.C.; McBride K.M.; Majewski J.; Gazumyan A.; Seneviratne S.; Grimbacher B.; Kutukculer N.; Herceg Z.; Cavazzana M.; Jabado N.; Nussenzweig M.C.; Fischer A.; Durandy A.
An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex
Journal of Allergy and Clinical Immunology 135 (4): 998-1007.e6 (2015-04)



2013

Callen E.; Di Virgilio M.; Kruhlak M.J.; Nieto-Soler M.; Wong N.; Chen H.T.; Faryabi R.B.; Polato F.; Santos M.; Starnes L.M.; Wesemann D.R.; Lee J.E.; Tubbs A.; Sleckman B.P.; Daniel J.A.; Ge K.; Alt F.W.; Fernandez-Capetillo O.; Nussenzweig M.C.; Nussenzweig A.
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions
Cell 153 (6): 1266-1280 (2013-06-06)



Di Virgilio M.; Callen E.; Yamane A.; Zhang W.; Jankovic M.; Gitlin A.D.; Feldhahn N.; Resch W.; Oliveira T.Y.; Chait B.T.; Nussenzweig A.; Casellas R.; Robbiani D.F.; Nussenzweig M.C.
Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching
Science 339 (6120): 711-715 (2013-02-08)



2011

Klein I.A.; Resch W.; Jankovic M.; Oliveira T.; Yamane A.; Nakahashi H.; Di Virgilio M.; Bothmer A.; Nussenzweig A.; Robbiani D.F.; Casellas R.; Nussenzweig M.C.
Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes
Cell 147 (1): 95-106 (2011-09-30)



Bothmer A.; Robbiani D.F.; Di Virgilio M.; Bunting S.F.; Klein I.A.; Feldhahn N.; Barlow J.; Chen H.T.; Bosque D.; Callen E.; Nussenzweig A.; Nussenzweig M.C.
Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1
Molecular Cell 42 (3): 319-329 (2011-05-06)



Gazumyan A.; Timachova K.; Yuen G.; Siden E.; Di Virgilio M.; Woo E.M.; Chait B.T.; Reina San-Martin B.; Nussenzweig M.C.; McBride K.M.
Amino-terminal phosphorylation of activation-induced cytidine deaminase suppresses c-myc/IgH translocation
Molecular and Cellular Biology 31 (3): 442-429 (2011-02)



2010

Pavri R.; Gazumyan A.; Jankovic M.; Di Virgilio M.; Klein I.; Ansarah-Sobrinho C.; Resch W.; Yamane A.; Reina San-Martin B.; Barreto V.; Nieland T.J.; Root D.E.; Casellas R.; Nussenzweig M.C.
Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5
Cell 143 (1): 122-133 (2010-10-01)



2009

Di Virgilio M.; Ying C.Y.; Gautier J.
PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin
DNA Repair 8 (11): 1311-1320 (2009-11-02)



Callen E.; Jankovic M.; Wong N.; Zha S.; Chen H.T.; Difilippantonio S.; Di Virgilio M.; Heidkamp G.; Alt F.W.; Nussenzweig A.; Nussenzweig M.
Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes
Molecular Cell 34 (3): 285-297 (2009-05-15)



2008

Dorsett Y.; McBride K.M.; Jankovic M.; Gazumyan A.; Thai T.H.; Robbiani D.F.; Di Virgilio M.; Reina San-Martin B.; Heidkamp G.; Schwickert T.A.; Eisenreich T.; Rajewsky K.; Nussenzweig M.C.
MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation
Immunity 28 (5): 630-638 (2008-05-16)



2005

Di Virgilio M.; Gautier J.
Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11
Journal of Cell Biology 171 (5): 765-771 (2005-12-05)



2002

Miranda C.; Di Virgilio M.; Selleri S.; Zanotti G.; Pagliardini S.; Pierotti M.A.; Greco A.
Novel pathogenic mechanisms of congenital insensitivity to pain with anhidrosis genetic disorder unveiled by functional analysis of neurotrophic tyrosine receptor kinase type 1/nerve growth factor receptor mutations
Journal of Biological Chemistry 277 (8): 6455-6462 (2002-02-22)