Publikationen



2017

Baras N.; Dahm S.; Haberland J.; Janz M.; Emrich K.; Kraywinkel K.; Salama A.
Subsequent malignancies among long-term survivors of Hodgkin lymphoma and non-Hodgkin lymphoma: a pooled analysis of German cancer registry data (1990-2012)
British Journal of Haematology 177 (2): 226-242 (2017-04)



Wurster K.D.; Hummel F.; Richter J.; Giefing M.; Hartmann S.; Hansmann M.L.; Kreher S.; Koechert K.; Krappmann D.; Klapper W.; Hummel M.; Wenzel S.S.; Lenz G.; Janz M.; Doerken B.; Siebert R.; Mathas S.
Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma
Leukemia 31 (3): 602-613 (2017-03)



Du J.; Neuenschwander M.; Yu Y.; Daebritz J.H.M.; Neuendorff N.R.; Schleich K.; Bittner A.; Milanovic M.; Beuster G.; Radetzki S.; Specker E.; Reimann M.; Rosenbauer F.; Mathas S.; Lohneis P.; Hummel M.; Doerken B.; von Kries J.P.; Lee S.; Schmitt C.A.
Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin's lymphoma
Blood 129 (1): 71-81 (2017-01-12)



2016

Mathas S.; Hartmann S.; Kueppers R.
Hodgkin lymphoma: pathology and biology
Seminars in Hematology 53 (3): 139-147 (2016-07)



Derudder E.; Herzog S.; Labi V.; Yasuda T.; Koechert K.; Janz M.; Villunger A.; Schmidt-Supprian M.; Rajewsky K.
Canonical NF-{kappa}B signaling is uniquely required for the long-term persistence of functional mature B cells
Proceedings of the National Academy of Sciences of the United States of America 113 (18): 5065-5070 (2016-05-03)



de Oliveira K.A.P.; Kaergel E.; Heinig M.; Fontaine J.F.; Patone G.; Muro E.M.; Mathas S.; Hummel M.; Andrade-Navarro M.A.; Huebner N.; Scheidereit C.
A roadmap of constitutive NF-{kappa}B activity in Hodgkin lymphoma: dominant roles of p50 and p52 revealed by genome-wide analyses
Genome Medicine 8 (1): 28 (2016-03-17)



Engert A.; Balduini C.; Brand A.; Coiffier B.; Cordonnier C.; Doehner H.; Duyvene' de Wit T.; Eichinger S.; Fibbe W.; Green T.; de Haas F.; Iolascon A.; Jaffredo T.; Rodeghiero F.; Salles G.; Schuringa J.J.
The European Hematology Association Roadmap for European Hematology Research: a consensus document
Haematologica 101 (2): 115-208 (2016-02)



2015

Ullrich K.; Blumenthal-Barby F.; Lamprecht B.; Koechert K.; Lenze D.; Hummel M.; Mathas S.; Doerken B.; Janz M.
The IL-15 cytokine system provides growth and survival signals in hodgkin lymphoma and enhances the inflammatory phenotype of HRS cells
Leukemia 29 (5): 1213-1218 (2015-05)



Behringer K.; Goergen H.; Hitz F.; Zijlstra J.M.; Greil R.; Markova J.; Sasse S.; Fuchs M.; Topp M.S.; Soekler M.; Mathas S.; Meissner J.; Wilhelm M.; Koch P.; Lindemann H.W.; Schalk E.; Semrau R.; Kriz J.; Vieler T.; Bentz M.; Lange E.; Mahlberg R.; Hassler A.; Vogelhuber M.; Hahn D.; Mezger J.; Krause S.W.; Skoetz N.; Boell B.; von Tresckow B.; Diehl V.; Hallek M.; Borchmann P.; Stein H.; Eich H.; Engert A.
Omission of dacarbazine or bleomycin, or both, from the ABVD regimen in treatment of early-stage favourable Hodgkin's lymphoma (GHSG HD13): an open-label, randomised, non-inferiority trial
Lancet 385 (9976): 1418-1427 (2015-04-11)



Weilemann A.; Grau M.; Erdmann T.; Merkel O.; Sobhiafshar U.; Anagnostopoulos I.; Hummel M.; Siegert A.; Hayford C.; Madle H.; Wollert-Wulf B.; Fichtner I.; Doerken B.; Dirnhofer S.; Mathas S.; Janz M.; Emre N.C.T.; Rosenwald A.; Ott G.; Lenz P.; Tzankov A.; Lenz G.
Essential role of IRF4 and MYC signaling for survival of anaplastic large cell lymphoma
Blood 125 (1): 124-132 (2015-01-01)



2014

Kreher S.; Bouhlel M.A.; Cauchy P.; Lamprecht B.; Li S.; Grau M.; Hummel F.; Koechert K.; Anagnostopoulos I.; Joehrens K.; Hummel M.; Hiscott J.; Wenzel S.S.; Lenz P.; Schneider M.; Kueppers R.; Scheidereit C.; Giefing M.; Siebert R.; Rajewsky K.; Lenz G.; Cockerill P.N.; Janz M.; Doerken B.; Bonifer C.; Mathas S.
Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma
Proceedings of the National Academy of Sciences of the United States of America 111 (42): E4513-E4522 (2014-10-21)



Rehm A.; Gaetjen M.; Gerlach K.; Scholz F.; Mensen A.; Gloger M.; Heinig K.; Lamprecht B.; Mathas S.; Begay V.; Leutz A.; Lipp M.; Doerken B.; Hoepken U.E.
Dendritic cell-mediated survival signals in E{my}-Myc B-cell lymphoma depend on the transcription factor C/EBP{beta}
Nature Communications 5: 5057 (2014-09-30)



2013

Nogai H.; Wenzel S.S.; Hailfinger S.; Grau M.; Kaergel E.; Seitz V.; Wollert-Wulf B.; Pfeifer M.; Wolf A.; Frick M.; Dietze K.; Madle H.; Tzankov A.; Hummel M.; Doerken B.; Scheidereit C.; Janz M.; Lenz P.; Thome M.; Lenz G.
I{kappa}B-{zeta} controls the constitutive NF-{kappa}B target gene network and survival of ABC DLBCL
Blood 122 (13): 2242-2250 (2013-09-26)



Pfeifer M.; Grau M.; Lenze D.; Wenzel S.S.; Wolf A.; Wollert-Wulf B.; Dietze K.; Nogai H.; Storek B.; Madle H.; Doerken B.; Janz M.; Dirnhofer S.; Lenz P.; Hummel M.; Tzankov A.; Lenz G.
PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma
Proceedings of the National Academy of Sciences of the United States of America 110 (30): 12420-12425 (2013-07-23)



Schwefel D.; Arasu B.S.; Marino S.F.; Lamprecht B.; Koechert K.; Rosenbaum E.; Eichhorst J.; Wiesner B.; Behlke J.; Rocks O.; Mathas S.; Daumke O.
Structural insights into the mechanism of GTPase activation in the GIMAP family
Structure 21 (4): 550-559 (2013-04-02)



2012

Calado D.P.; Sasaki Y.; Godinho S.A.; Pellerin A.; Koechert K.; Sleckman B.P.; de Alboran I.M.; Janz M.; Rodig S.; Rajewsky K.
The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers
Nature Immunology 13 (11): 1092-1100 (2012-11)



2011

Ullrich K.; Wurster K.D.; Lamprecht B.; Koechert K.; Engert A.; Doerken B.; Janz M.; Mathas S.
BAY 43-9006/Sorafenib blocks CSF1R activity and induces apoptosis in various classical Hodgkin lymphoma cell lines
British Journal of Haematology 155 (3): 398-402 (2011-11)



Steininger A.; Moebs M.; Ullmann R.; Koechert K.; Kreher S.; Lamprecht B.; Anagnostopoulos I.; Hummel M.; Richter J.; Beyer M.; Janz M.; Klemke C.D.; Stein H.; Doerken B.; Sterry W.; Schrock E.; Mathas S.; Assaf C.
Genomic loss of the putative tumor suppressor gene E2A in human lymphoma
Journal of Experimental Medicine 208 (8): 1585-1593 (2011-08-01)



Fagerli U.M.; Ullrich K.; Stuehmer T.; Holien T.; Koechert K.; Holt R.U.; Bruland O.; Chatterjee M.; Nogai H.; Lenz G.; Shaughnessy J.D.; Mathas S.; Sundan A.; Bargou R.C.; Doerken B.; Borset M.; Janz M.
Serum/glucocorticoid-regulated kinase 1 (SGK1) is a prominent target gene of the transcriptional response to cytokines in multiple myeloma and supports the growth of myeloma cells
Oncogene 30 (28): 3198-3206 (2011-07-14)



Koechert K.; Ullrich K.; Kreher S.; Aster J.C.; Kitagawa M.; Joehrens K.; Anagnostopoulos I.; Jundt F.; Lamprecht B.; Zimber-Strobl U.; Stein H.; Janz M.; Doerken B.; Mathas S.
High-level expression of Mastermind-like 2 contributes to aberrant activation of the NOTCH signaling pathway in human lymphomas
Oncogene 30 (15): 1831-1840 (2011-04-14)



2010

Lamprecht B.; Bonifer C.; Mathas S.
Repeat-element driven activation of proto-oncogenes in human malignancies
Cell Cycle 9 (21): 4276-4281 (2010-11)



Ratei R.; Hummel M.; Anagnostopoulos I.; Jaehne D.; Arnold R.; Doerken B.; Mathas S.; Thomas B.; Dudeck O.; Ludwig W.D.; Stein H.
Common clonal origin of an acute B lymphoblastic leukemia and a Langerhans' cell sarcoma: evidence for hematopoietic plasticity
Haematologica 95 (9): 1461-1466 (2010-09)



Lamprecht B.; Walter K.; Kreher S.; Kumar R.; Hummel M.; Lenze D.; Koechert K.; Bouhlel M.A.; Richter J.; Soler E.; Stadhouders R.; Joehrens K.; Wurster K.D.; Callen D.F.; Harte M.F.; Giefing M.; Barlow R.; Stein H.; Anagnostopoulos I.; Janz M.; Cockerill P.N.; Siebert R.; Doerken B.; Bonifer C.; Mathas S.
Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma
Nature Medicine 16 (5): 571-579, 1p following 579 (2010-05)



2009

Mathas S.; Misteli T.
The dangers of transcription
Cell 139 (6): 1047-1049 (2009-12-11)



Pal R.; Janz M.; Galson D.L.; Gries M.; Li S.; Johrens K.; Anagnostopoulos I.; Doerken B.; Mapara M.Y.; Borghesi L.; Kardava L.; Roodman G.D.; Milcarek C.; Lentzsch S.
C/EBP{beta} regulates transcription factors critical for proliferation and survival of multiple myeloma cells
Blood 114 (18): 3890-3898 (2009-10-29)



Mathas S.; Kreher S.; Meaburn K.J.; Joehrens K.; Lamprecht B.; Assaf C.; Sterry W.; Kadin M.E.; Daibata M.; Joos S.; Hummel M.; Stein H.; Janz M.; Anagnostopoulos I.; Schrock E.; Misteli T.; Doerken B.
Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma
Proceedings of the National Academy of Sciences of the United States of America 106 (14): 5831-5836 (2009-04-07)



2008

Schwarzer R.; Kaiser M.; Acikgoez O.; Heider U.; Mathas S.; Preissner R.; Sezer O.; Doerken B.; Jundt F.
Notch inhibition blocks multiple myeloma cell-induced osteoclast activation
Leukemia 22 (12): 2273-2277 (2008-12)



Lamprecht B.; Kreher S.; Anagnostopoulos I.; Joehrens K.; Monteleone G.; Jundt F.; Stein H.; Janz M.; Doerken B.; Mathas S.
Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3{alpha}
Blood 112 (8): 3339-3347 (2008-10-15)



Janz M.; Mathas S.
The pathogenesis of classical Hodgkin's lymphoma: what can we learn from analyses of genomic alterations in Hodgkin and Reed-Sternberg cells?
Haematologica 93 (9): 1292-1295 (2008-09)



Jundt F.; Acikgoez O.; Kwon S.H.; Schwarzer R.; Anagnostopoulos I.; Wiesner B.; Mathas S.; Hummel M.; Stein H.; Reichardt H.M.; Doerken B.
Aberrant expression of Notch1 interferes with the B-lymphoid phenotype of neoplastic B cells in classical Hodgkin lymphoma
Leukemia 22 (8): 1587-1594 (2008-08)



2007

Lietz A.; Janz M.; Sigvardsson M.; Jundt F.; Doerken B.; Mathas S.
Loss of bHLH transcription factor E2A activity in primary effusion lymphoma confers resistance to apoptosis
British Journal of Haematology 137 (4): 342-348 (2007-05)



Janz M.; Stuehmer T.; Vassilev L.T.; Bargou R.C.
Pharmacologic activation of p53-dependent and p53-independent apoptotic pathways in Hodgkin/Reed-Sternberg cells
Leukemia 21 (4): 772-779 (2007-04)



2006

Martin-Subero J.I.; Wlodarska I.; Bastard C.; Picquenot J.M.; Hoeppner J.; Giefing M.; Klapper W.; Siebert R.; Mathas S.; Joos S.; Stein H.; Doerken B.
Chromosomal rearrangements involving the BCL3 locus are recurrent in classical Hodgkin and peripheral T-cell lymphoma
Blood 108: 401-403 (2006-07-01)



Sturm I.; Stephan C.; Gillissen B.; Siebert R.; Janz M.; Radetzki S.; Jung K.; Loening S.; Doerken B.; Daniel P.T.
Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma
Cell Death and Differentiation 13: 619-627 (2006-04)



Janz M.; Hummel M.; Truss M.; Wollert-Wulf B.; Mathas S.; Joehrens K.; Hagemeier C.; Bommert K.; Stein H.; Doerken B.; Bargou R.C.
Classical Hodgkin lymphoma is characterized by high constitutive expression of activating transcription factor 3 (ATF3) which promotes viability of Hodgkin/Reed-Sternberg cells
Blood 107 (6): 2536-2539 (2006-03-15)



Mathas S.; Janz M.; Hummel F.; Hummel M.; Wollert-Wulf B.; Lusatis S.; Anagnostopoulos I.; Lietz A.; Sigvardsson M.; Jundt F.; Joehrens K.; Bommert K.; Stein H.; Doerken B.
Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma
Nature Immunology 7 (2): 207-215 (2006-02)



2005

Mathas S.; Joehrens K.; Joos S.; Lietz A.; Hummel F.; Janz M.; Jundt F.; Anagnostopoulos I.; Bommert K.; Lichter P.; Stein H.; Scheidereit C.; Doerken B.
Elevated NF-kappaB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large cell, and other peripheral T-cell lymphomas
Blood 106 (13): 4287-4293 (2005-08-25)



Jundt F.; Raetzel N.; Mueller C.; Calkhoven C.F.; Kley K.; Mathas S.; Lietz A.; Leutz A.; Doerken B.
A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein beta and NF-kappaB activity in Hodgkin and anaplastic large cell lymphomas
Blood 106: 1801-1807 (2005-01-01)



Koh K.R.; Janz M.; Mapara M.Y.; Lemke B.; Stirling D.; Doerken B.; Zenke M.; Lentzsch S.
Immunomodulatory derivative of thalidomide (IMiD CC-4047) induces a shift in lineage commitment by suppressing erythropoiesis and promoting myelopoiesis
Blood 105 (10): 3833-3840 (2005-01-01)



2004

Mathas S.; Lietz A.; Anagnostopoulos I.; Hummel F.; Wiesner B.; Janz M.; Jundt F.; Hirsch B.; Joehrens-Leder K.; Vornlocher H.P.; Bommert K.; Stein H.; Doerken B.
c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis
Journal of Experimental Medicine 199 (8): 1041-1052 (2004-04-19)



Jundt F.; Schulze-Proebsting K.; Anagnostopoulos I.; Muehlinghaus G.; Chatterjee M.; Mathas S.; Bargou R.C.; Manz R.; Stein H.; Doerken B.
Jagged1-induced notch signaling drives proliferation of multiple myeloma cells
Blood 103 (9): 3511-3515 (2004-01-01)



2003

Mathas S.; Lietz A.; Janz M.; Hinz M.; Jundt F.; Scheidereit C.; Bommert K.; Doerken B.
Inhibition of NF-{kappa} B essentially contributes to arsenic-induced apoptosis
Blood 102 (3): 1028-1034 (2003-08-01)



Lentzsch S.; Gries M.; Janz M.; Bargou R.; Doerken B.; Mapara M.Y.
Macrophage inflammatory protein 1-alpha (MIP-1alpha) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells
Blood 101 (9): 3568-3573 (2003-05-01)



Juerchott K.; Bergmann S.; Stein U.; Walther W.; Janz M.; Manni I.; Piaggio G.; Fietze E.; Dietel M.; Royer H.D.
YB-1 as a cell cycle-regulated transcription factor facilitating cyclin A and cyclin B1 gene expression
Journal of Biological Chemistry 278 (30): 27988-27996 (2003-01-01)



2002

Chatterjee M.; Hoenemann D.; Lentzsch S.; Bommert K.; Sers C.; Herrmann P.; Mathas S.; Doerken B.; Bargou R.C.
In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6/gp 130/STAT3 pathway
Blood 100 (9): 3311-3318 (2002-11-01)



Hinz M.; Lemke P.; Anagnostopoulos I.; Hacker C.; Krappmann D.; Mathas S.; Doerken B.; Zenke M.; Stein H.; Scheidereit C.
Nuclear factor {kappa}B-dependent gene expression profiling of Hodgkins disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity
Journal of Experimental Medicine 196 (5): 605-617 (2002-09-02)



Mathas S.; Hinz M.; Anagnostopoulos L.; Krappmann D.; Lietz A.; Jundt F.; Bommert K.; Mechta-Grigoriou F.; Stein H.; Doerken B.; Scheidereit C.
Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B
EMBO Journal 21 (15): 4104-4113 (2002-08-01)



Jundt F.; Anagnostopoulos I.; Foerster R.; Mathas S.; Stein H.; Doerken B.
Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma
Blood 99 (9): 3398-3403 (2002-05-01)



Jundt F.; Kley K.; Anagnostopoulos I.; Schulze-Proebsting K.; Greiner A.; Mathas S.; Scheidereit C.; Wirth T.; Stein H.; Doerken B.
Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease
Blood 99 (8): 3060-3062 (2002-04-15)



Janz M.; Harbeck N.; Dettmar P.; Berger U.; Schmidt A.; Juerchott K.; Schmitt M.; Royer H.D.
Y-box factor YB-1 predicts drug resistance and patient outcome in breast cancer independent of clinically relevant tumor biologic factors HER2, uPA and PAI-1
International Journal of Cancer 97 (3): 278-282 (2002-01-01)



2001

Hinz M.; Loeser P.; Mathas S.; Krappmann D.; Doerken B.; Scheidereit C.
Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells
Blood 97 (9): 2798-2807 (2001-01-01)



2000

Mathas S.; Rickers A.; Bommert K.; Doerken B.; Mapara M.Y.
Anti-CD20-and B-cell receptor-mediated apoptosis: Evidence for shared intracellular signaling pathways
Cancer Research 60 (24): 7170-7176 (2000-01-01)



1999

Emmerich F.; Meiser M.; Hummel M.; Demel G.; Foss H.D.; Jundt F.; Mathas S.; Krappmann D.; Scheidereit C.; Stein H.; Doerken B.
Overexpression of IkappaBalpha without inhibition of NF-kappaB activity and mutations in the IkappaBalpha gene in Reed-Sternberg cells
Blood 94: 3129-3134 (1999-11-01)