Stammzell-Modellierung der Entwicklung und Erkrankung

Gruppenleiter

Dr. Mina Gouti

27: Walter-Friedrich Haus

Raum 012

Tel. 2610

Fax.

Contact


Sekretariat

Beate Valeske

27: Walter-Friedrich Haus

Raum 243

Tel. 2507

Fax. 2547

Contact


We use human and mouse pluripotent stem cells to model and understand normal and pathological development of the neuromuscular system. Following the cues from mouse embryonic development we have recently succeeded in generating spinal cord neurons from a neuromesodermal progenitor population (NMP). This in vitro system opens up new opportunities for the study and treatment of neuromuscular diseases due to its great advantage of simultaneously generating cell types of neural and mesodermal origin in the “dish”. Our focus is understanding how these two tissues are generated in space and time during development, how they interact and, intriguingly, how defects in early development of these tissues can lead to different predisposition to disease in the adult life. To address these questions we are using gain and loss of gene function approaches (Crispr/Cas9 system), single cell genomics (RNA-seq) as well as live cell imaging techniques on human and mouse pluripotent stem cells.

 

For more information please visit Gouti Lab Website