Prof. Dr. Helmut Kettenmann


Cellular Neuroscience

Max-Delbrück-Center for Molecular Medicine

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Research Interest:

Our goal is to understand the role of glial cells in physiology and pathology. We focus on questions as to how neuronal activity is sensed by astrocytes, how astrocytes communicate among each other, and how they feedback on neurons. A second focus addresses the expression of transmitter receptors in microglial cells and how activation of these receptors influences microglial function. This is of particular interest within the context of pathology and we are currently studying this question in stroke and gliomas. A third line of research addresses the question as to how glioma cells interact with the intrinsic brain cells, specifically microglia and stem cells. We are aiming to understand this interaction on a molecular level, in particular with the hope of identifying tools which impair glioma invasion.

 

Selected Publications:

 

Benedetti B; Matyash V; Kettenmann H (2011) Astrocytes control GABAergic inhibition of neurons in the mouse barrel cortex J Physiol.589(Pt 5):1159-72

 

Reyes-Haro D, Müller J, Boresch M, Pivneva T, Benedetti B, Scheller A, Nolte C, Kettenmann H (2010) Neuron-astrocyte interactions in the medial nucleus of the trapezoid body. J Gen Physiol. 135(6):583-94.

 

Maglione M, Tress O, Haas B, Karram K, Trotter J, Willecke K, Kettenmann H. (2010) Oligodendrocytes in mouse corpus callosum are coupled via gap junction channels formed by connexin47 and connexin32. Glia. 58(9):1104-17.

 

Markovic DS, Vinnakota K, Chirasani S, Synowitz M, Raguet H, Stock K, Sliwa M, Lehmann S, Kälin R, van Rooijen N, Holmbeck K, Heppner FL, Kiwit J, Matyash V, Lehnardt S, Kaminska B, Glass R, Kettenmann H. (2009) Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion. PNAS 106(30):12530-5.

 

Müller J, Reyes-Haro D, Pivneva T, Nolte C, Schaette R, Lübke J, Kettenmann H. (2009) The principal neurons of the medial nucleus of the trapezoid body and NG2(+) glial cells receive coordinated excitatory synaptic input. J Gen Physiol. 134(2):115-27.

 

Peters O, Schipke CG, Philipps A, Haas B, Pannasch U, Wang LP, Benedetti B,Kingston AE, Kettenmann H. (2009) Astrocyte function is modified by Alzheimer'sdisease-like pathology in aged mice. J Alzheimers Dis. 18(1):177-89

 

Cheung G, Kann O, Kohsaka S, Făerber K, Kettenmann H. (2009) GABAergic activities enhance macrophage inflammatory protein-1alpha release from microglia (brain macrophages) in postnatal mouse brain. J Physiol. 587(Pt 4):753-68.

 

Wang LP, Cheung G, Kronenberg G, Gertz K, Ji S, Kempermann G, Endres M, Kettenmann H. (2008) Mild brain ischemia induces unique physiological properties in striatal astrocytes. Glia. 56(9):925-34.

 

Färber K, Markworth S, Pannasch U, Nolte C, Prinz V, Kronenberg G, Gertz K, Endres M, Bechmann I, Enjyoji K, Robson SC, Kettenmann H. (2008) The ectonucleotidase cd39/ENTPDase1 modulates purinergic-mediated microglial migration. Glia. 56(3):331-41.

 

Hanisch UK, Kettenmann H (2007) . Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci. 10(11):1387-94.

 

Färber, K., Markworth, S., Pannasch, U., Prinz, V., Kronenberg, G., Gertz, K., Endres, M., Enjyoji, K., Robson, S. C. and Kettenmann H. (2008) The ectonucleotidase cd39/ENTPDase1 modulates purinergic-mediated microglial migration, Glia, 56:331-341.

 

Schipke C. G., Haas B. and Kettenmann H. (2008), Astrocytes Discriminate and Selectively Respond to the Activity of a Subpopulation of Neurons within the Barrel Cortex Cereb Cortex, published on March 4, 2008; doi: doi:10.1093/cercor/bhn009

 

Waelzlein JH, Synowitz M., Engels B., Markovic D. S., Gabrusiewicz K., Nikolaev E. Yoshikawa K., Kaminska B., Kempermann G., Uckert W.,Kaczmarek L., Kettenmann H., and Glass R. (2008), The anti-tumorigenic response of neural precursors depends on subventricular proliferation and age. Stem Cells Express, published online August 28, 2008; doi:10.1634/stemcells.2008-0307

 

Hanisch, UK and Kettenmann, H. (2007) Microglia – active sensor and versatile effector cells in the normal and pathologic brain, Nat. Neurosci. 10:1387 – 1394.