Research and Technologies
Research at the BIMSB is focused on understanding all levels of gene regulatory networks in both health and disease states - epigenetic, transcriptional and post-transcriptional processes as well as major cellular regulatory mechanisms, such as protein-protein and protein-nucleic acid interaction networks, signal transduction pathways, post-translational modifications and metabolic feedback. The aim is to generate quantitative models that predict how genes and their products act in concert to give rise to specific phenotypes.
BIMSB researchers apply quantitative experimental and theoretical approaches to model systems suitable for multi-level high-throughput analyses. Model organisms such as Drosophila, nematodes and flatworms, fish, mice and cell culture are employed as they are particularly amenable to systems-wide investigations. Major research projects address basic cell biology, developmental biology, regeneration, stem cell biology, immunology, genetic variability as well as health questions including cancer, obesity, metabolism, cardiovascular and neurological diseases. Our long-term goal is the improvement of both diagnosis and therapy of diseases through personalized medicine by facilitating specific targeting of treatment regimens to subsets of responding patients.
For an overview of BIMSB publications, see our .