Master thesis: "Investigating how receptor subcellular distribution affects signaling specificity"
G protein-coupled receptors (GPCRs) form the largest class of membrane-bound receptors and represent one of the most important drug targets. Activation of GPCRs by extracellular ligands leads to a highly complex intracellular signaling pattern. In the context of a DFG funded project, we are now investigating by means of advanced fluorescence spectroscopy and microscopy methods the the effect that subcellular localization of receptors has on modulating downstream signaling. The project will involve (i) molecular cloning of new constructs and receptor mutants which affect their interaction with intracellular structures, most prominently the cortical actin scaffold; (ii) single molecule fluorescence imaging of these receptors, their dynamics and their coupling to downstream effectors.
The successful applicant will have a Bachelor’s degree in Molecular Biology, Biophysics, Biochemistry or scientifically-related areas. A background in cell culture and molecular cloning is expected. Experience with fluorescence microscopy is advantageous. The successful applicant should be highly motivated and willing to work in an interdisciplinary team of international scientists.
The MDC is committed to diversity and actively supports equal opportunities for all employees regardless of their origin, religion, ideology, disability, age or sexual identity. Applications from woman are explicity encourage. Severely disabled persons will be given preferential treatment in the case of equal qualification.
The MDC is an equal opportunity employer and supports gender equality.
Please submit your application as one pdf file (5 MB max, including a cover letter, CV, references as well as relevant educational and degree certificates) indicating the registration number to firstname.lastname@example.org
Collective agreement for student employees