The Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) is a leading international biomedical research center with the goal of elucidating the molecular mechanisms of health and disease in order to create the basis for new therapies and diagnostic procedures. The MDC is a member of the largest scientific organization in Germany - the Helmholtz Association - and offers a stimulating and interactive research environment with the most modern infrastructure. Currently, 1,250 employees and approximately 500 guests work at the locations in Berlin-Buch and Berlin-Mitte. The diversity of our workforce is a strength and promotes creativity and innovative spirit at the MDC.
An ERC funded post-doctoral position is available in the research group of Dr. Ilaria
Piazza at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association
(MDC) in Berlin, Germany
The Piazza laboratory ( ) uses mass spectrometry-based approaches to study protein conformational changes in cell and tissues integrating proteomics and metabolomics data with structural biology. The successful candidates will devise new proteomics methods to measure protein-metabolite and protein-drug interactions. You will work on an exciting project that aims to understand how metabolic alterations alter proteome dynamics, obtaining biological insights about protein allostery.
You will join a young and enthusiastic team of scientists working at the cutting edge of proteomics ( You will focus on the application of advanced proteomics analyses based on data-independent acquisition (DIA) mass spectrometry and apply relevant bioinformatics approaches. You will have access to state-of-the-art instrumentation and be involved in international cross-disciplinary collaborations. The successful candidate will take a strong lead in the experimental design and data interpretation collaborating with other team members.
Applicants should have a solid experimental or computational background, a strong publication record as primary author, and excellent communication skills in English. Knowledge of German is not required.
The candidate should have:
- A PhD in biochemistry, systems biology, molecular biology or equivalent
- A strong interest in proteomics, technology development and quantitative biology.
- General knowledge of label free mass spectrometry-based proteomics techniques, experience in handling Orbitrap mass spectrometers such as Thermo HF-X or
Exploris 480, and proteomics data analysis with R, python or shiny applications.
- Bioinformatic analysis of proteomics data based on correlations, pathway enrichment, signature motif analysis, and machine learning for class discovery and
- Previous experience with work with human cancer cell lines or budding yeast (S.
cerevisiae) is a plus.
- Programming skills with Python or R is a plus.
- Ability to work independently and in teams. Excellent communication skills.
A strong interest in interdisciplinary research and integration of metabolomics and proteomics concepts are the requisite skills for this position, thus applicants wishing to integrate computational and experimental biology approaches are specifically encouraged to apply.
- International working environment with communication in English and German
- Interesting career opportunities and a comprehensive range of qualification and further training opportunities
- Compatibility of family and career certified by the berufundfamilie audit
- Varied support for "New Berliners" (Welcome & Family Office)
- Company health management with fitness center
A remuneration in accordance with the collective agreement for the federal public service (TVöD-Bund), including additional company pension schemes
- Flexible working hours and childcare support
- An idyllic green campus, which is easily accessible by bicycle, public transport or car