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Allosteric Proteomics Lab

The Max Delbrück Center for Molecular Medicine (MDC) is a member of the Helmholtz Association of National Research Centers, supported by the Federal Government of Germany and the Senate of Berlin. It is dedicated to interdisciplinary biomedical research with the aim to translate basic research findings into clinical applications. At its two research locations in Berlin the MDC is expanding in relevant biomedical research fields, for example, Medical Systems Biology, including Imaging Technologies and Data Sciences. Research at the MDC covers a wide range of applications from basic sciences to (pre-)clinical research in various areas of diseases. Research groups and technology platforms are integrated in numerous collaborative research projects and technology developments with national and international partners.

A post-doctoral position is available in the research group of Dr. Ilaria Piazza at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) in Berlin, Germany.

The Piazza laboratory ( uses mass spectrometry- based approaches to identify protein-small molecule interactions on a large scale and directly from complex cell and tissues. The group studies protein conformational changes integrating multi-omic data with structural biology. The successful candidate will devise new methods to measure dynamic proteome structural changes and their functional consequences. You will derive novel biological insights analyzing the relationship between metabolic alterations and eukaryotic gene expression.

You will join a young and enthusiastic team of scientists working at the cutting edge of proteomics and genomics ( You will learn advanced structural proteomics analyses based on data-independent acquisition mass spectrometry and apply relevant bioinformatics approaches. You will have access to state-of-the-art instrumentation and be involved in international cross-disciplinary collaborations.


Applicants should have a solid experimental or computational background, a strong publication record as primary author, and excellent communication skills in English. German language skills are welcome, but can also be acquired during the contract period in German courses offered by the MDC. A strong interest in interdisciplinary technology development, and system biology concepts are the requisite skills for this position. The candidate will be responsible for the experimental and data analysis design. You will integrate different kinds of genomic and proteomics data to answer biologically relevant questions about protein allostery and epigenetics. Previous experience with human cancer cell lines or budding yeast (S. cerevisiae), genome editing and bioinformatics are highly recommended. The ability to work independently and creatively contribute to the design of the research project are essential.

Applicants wishing to integrate computational and experimental biology approaches are specifically encouraged to apply. Familiarity with large-scale data sets and proteomics is preferable but not required.

The MDC is committed to diversity and actively supports equal opportunities for all employees regardless of their origin, religion, ideology, disability, age or sexual identity. We look forward to applications from people who are open-minded and enjoy working in joint teams. Severely disabled persons will be given preferential treatment in the case of equal qualification.

The MDC is certified by the “work and family” audit and provides an inclusive and family friendly environment und-familie. Applications from women are explicitly encouraged


The position is funded according to the German TVÖD (Bund) E13 based on experience and qualification.

Start date

The position is immediately available.


The initial contract will be offered for 2 years with the possibility of extension.

Application Period



Enquiries about the position should be addressed to For
information about the MDC, please visit our web site (

Postal address

Applications should be submitted by the July 20, 2020 indicating the registration number (job code 11247/2020) and include a cover letter, CV, references as well as relevant educational and degree certificates as one pdf file (5 MB max, to’).