The Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) is one of the world’s leading biomedical research institutions. Max Delbrück, a Berlin native, was a Nobel laureate and one of the founders of molecular biology. At the MDC’s locations in Berlin-Buch and Mitte, researchers from some 60 countries study human biology – investigating the foundations of life from its most elementary building blocks to systems-wide mechanisms. By understanding what regulates or disrupts the equilibrium of a cell, an organ, or the entire body, we can prevent diseases, diagnose them earlier, and stop their progression with tailored therapies. To enable timely application of research findings for improving human health, the MDC supports entrepreneurship and participates in collaborative networks. The MDC has a close partnership with the Charité - Universitätsmedizin Berlin in the jointly run Experimental and Clinical Research Center (ECRC), the Berlin Institute of Health (BIH) at Charité, and the German Center for Cardiovascular Research (DZHK). Founded in 1992, the MDC today employs 1,600 people and is funded 90 percent by the German federal government and 10 percent by the State of Berlin.
The Gotthardt Lab aims to develop a basic understanding of the transition from cardiovascular health to disease at the molecular, cellular, organ and systems level and use this information to improve patient care. After our identification of the splice regulator RBM20 as a therapeutic target, we are now evaluating the connection of two macromolecular machines - the spliceosome and sarcomere - in adapting cardiac contraction and filling. At the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) and the Charité Universitätsmedizin Berlin, our ultimate goal is to bring splice therapeutics to the clinic. In the Leduq Network CASTT, we work with labs from Boulder Colorado, Heidelberg, Lisbon and Stanford to evaluate cardiac splicing as a therapeutic target.
The MDC is one of the world's leading biomedical research institutions. At the locations in Berlin-Buch and Mitte, researchers from some 60 countries analyze the human system – investigating the biological foundations of life from its most elementary building blocks to systems-wide mechanisms. Patients should benefit as soon as possible from our basic research discoveries. The MDC therefore supports spin-off creation and participates in collaborative networks. It works in close partnership with Charité – Universitätsmedizin Berlin in the jointly run Experimental and Clinical Research Center (ECRC), the Berlin Institute of Health at Charité, and the German Center for Cardiovascular Research. The MDC today employs 1,600 people and is funded 90 percent by the German federal government and 10 percent by the State of Berlin.
As a postdoc in the Gotthardt lab, you will study cardiac splicing and sarcomere biology with the focus on mechanotransduction and single cell biology / multi-omics.
You will develop new strategies and therapeutic targets help improve biomechanical properties of the heart and improve remodeling. By using a combination of cell-biological, biochemical, and genetic tools as well as existing mouse and 3D-cell-culture models you will be able to uncover novel aspects of cardiomyocyte communication, growth, and adaptation. This work is third-party funded with the possibility for translation (preclinical), and involvement with small medium enterprises.
You should apply if you have finished your PhD or MD PhD in Biology, Molecular Biology, Biophysics, Biochemistry or related discipline. You should be highly motivated and interested to work at the interface of basic and translational research. Background in molecular biology and commonly used technics in cell biology is necessary. As we communicate and perform research in English, no prior knowledge in German is needed. Prior participation in or coordination of research networks is a plus.
- International working environment with communication in English and German
- Interesting career opportunities and a comprehensive range of qualification and further training opportunities
- Compatibility of family and career certified by the berufundfamilie audit
- Varied support for "New Berliners" (Welcome & Family Office)
- Company health management with fitness center
You also benefit from:
- A remuneration in accordance with the collective agreement for the federal public service (TVöD-Bund), including additional company pension schemes
- Flexible working hours and childcare support
- An idyllic green campus, which is easily accessible by bicycle, public transport or car
- A secure job, even in uncertain times
- Subsidy for the job ticket as well as discounts in the campus canteen
- Additional health benefits such as flu vaccination, eye test, ergonomics advice at the workplace, hygiene measures (medical mouth-nose protection, self-tests, disinfectants)
- The possibility of mobile working - also independent of the Corona situation
- Free use of Nextbike from the Buch S-Bahn station to the campus