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Postdoctoral fellow in Mass Spectrometry Metabolomics and Lipidomics

Job Code

10940

(funded by the Berlin Institute for Health, based at the Max Delbrück Center, Berlin)
NEW position for a mass spectrometry expert specialising in metabolomics and/or biochemistry
Make a difference!
We believe in selecting people based on their abilities, not on their stereotypes. We will strive to give all capable candidates an opportunity, irrespective of their race, genders, nationality or background. We are happy to discuss flexible work patterns if requested, job sharing or other solutions that enable strong candidates to work better.
Key words: Metabolomics, Lipidomics, Mass Spectrometry, Biochemistry, Analytical chemistry, Applied statistics, Pathway mapping, Omics data analysis

You will work as a key member of the Berlin Institute for Health (BIH) Metabolomics Platform (https://www.bihealth.org/en/research/core-facilities/metabolomics/) at the Max Delbrück Center for Molecular Medicine (https://www.mdc-berlin.de/metabolomics). The role is centered around planning, conducting and analyzing mass spectrometry-based metabolomics projects to elucidate the mechanisms of disease processes. You will be responsible for sample analysis in translational research projects in collaboration with other research groups, focusing on gut, heart and brain health and their connections. The work is varied and requires someone with a broad interest in both biochemistry and medicine and the ability to independently plan projects, write reports and meet deadlines.
Main Responsibilities

  • To provide biochemical and laboratory analytical support to the Metabolomics Platform of the BIH (Complex statistical support is largely provided by our bioinformaticians, but you will be expected to conduct basic statistical analyses including PCA and PLSDA yourself as part of the general analysis of data)
  • To collaborate with others to ensure robust data quality and high quality outputs including the writing of scientific papers
  • To continue using existing metabolomics pipelines to further the research of the BIH
  • To develop and implement new analytical methods or pipelines as they are required
  • Contribute to interdisciplinary biomedical projects: support experimental designs; present analysis results to coworkers and collaborators; integrate results with other omics data; contribute to interpretation of results; write scientific papers
  • To work on improving data reproducibility
  • Develop innovative scientific approaches when standard methods are not adequate

Requirements

The position requires expertise in design of experiments, mass spectrometry and metabolomics data analysis. Experience in statistical analysis, including multivariable modelling would be an advantage, especially as conducted in an R-based computing environment. Your role will be heavily collaborative although there will be an opportunity to conduct your own research within the remit of the aims of the BIH. One of the major requirements in your role is a willingness to share expertise with others to enable multidisciplinary projects to be carried out to an exceptionally high standard. Our team is passionate about transforming data into biomedical insight. The ideal candidate will be a team player with an in depth understanding of mass spectrometry, metabolomics and lipidomics.
Personal Specification

  • PhD in metabolomics, biochemistry, analytical chemistry or related field
  • Demonstrated experience of laboratory based metabolomics or mass spectrometry project work, including ability to complete projects to an excellent standard within reasonable timeframes
  • Demonstrated substantial experience in independent mass spectrometry chemical analysis and biochemical and statistical interpretation (experience in metabolomics analysis is a major advantage, as is experience in liquid and gas chromatography)
  • have good written and verbal communication skills in English (German language skills are a plus, but not essential)
  • Advantageous if you are highly numerate with a good understanding of both computational and statistical processes, good knowledge of data processing and analysis of mass-spectrometry data (high and low resolution instruments, MS and MSn including fragmentation analysis, liquid and gas chromatography mass spectrometry is a strong plus)
  • Good knowledge of statistical analysis of omics data, experience of functional analyses, particularly in metabolomics, including multivariate analysis and hierarchical clustering is a major advantage
  • Motivated to succeed with a love of learning and a desire to keep challenging yourself
  • Ability to learn quickly and to synthesize ideas from different subjects
  • Team-orientated with excellent organizational skills including project management and good record keeping is important
  • Have the ability to condense and present scientific results to both scientific and non specialist audiences

In order to reduce the risk of unconscious bias, please remove any information from your application about AGE, SEX, MARITAL STATUS, PERSONAL PHOTO or INFORMATION ABOUT CHILDREN (except where you wish to relate it to career breaks).

The MDC is an equal opportunity employer and supports gender equality.


Salary

Remuneration is according to the German TVöD (Bund) up to scale (E13).


Start date

as soon as possible


Limitation

Appointments are made for an initial period of two years with possibility of extension.


Application Period

The application deadline is 22th May 2018.


Contact

Questions can be directed to Dr. Kirwan at jennifer.kirwan@bihealth.de.

Please send, in English language, a letter of application, your C.V. and any supporting documents, preferably as one PDF file, by e-mail to sabrina.deter@mdc-berlin.de by indicating the registration number 10940/2018.