Jobs blur

Postdoctoral researcher in tissue mechanics and gene regulation (f/m/d)

Berlin-Mitte | MDC-BIMSB

The Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association is an international biomedical research center dedicated to understanding the molecular mechanisms of health and disease with the goal to devise new diagnostics and medicines. The MDC is a member of the Helmholtz Association, Germany's largest scientific organization, and offers an engaging research environment with cutting-edge research infrastructure. Currently, ~1250 employees and ~500 guest scientists work at the Berlin-Buch and Berlin-Mitte campuses. Our diverse workforce is a core strength that inspires creativity and innovation at the MDC.

The MDC is committed to improving human health through transformative biomedical research. Our goal is to pioneer discoveries for preventing, treating, and ultimately curing disease.

The Robson lab's goal is to understand how chromatin regulates gene expression and how this is disrupted in disease. We tackle this by combining single cell multi-omics and genome engineering with mouse and organoid models of disease.
The "Chromatin (Dys)function in disease"- group offers an exciting opportunity to explore an essential question: How do mechanical forces impact chromatin to regulate genes and cells? To do so, you will develop approaches that apply mechanical forces in organoids and mouse tissues and multi-omic methods that map the consequences for chromatin, genes and cells.

Job Description

Mechanically active cells such as muscle frequently experience physical forces that are transmitted directly to the nucleus. Yet, how this impacts chromatin and its elaborate structure to regulate gene expression or cause disease remains largely unknown.

The successful candidate will now address this by further developing genomics technologies (e.g. scDam&T) that simultaneously map protein:chromatin interactions and transcription in a single cell. We will then use these methods to explore the impact of physical force on chromatin, genes and cells in mechanically active cells from mice and neuromuscular organoids. We will particularly focus on investigating how disrupting force transmission contributes to muscular dystrophy.

Requirements

We are looking for a creative and enthusiastic Postdoc (m/f/d) with in-depth experience in chromatin biology, gene regulation, and genomics (wet-lab & computational). Prior experience in single cell genomics, mechanobiology, technology development, and organoid derivation is also strongly encouraged. Mice will also be a key model and so experience designing and performing animal experiments is advantageous.

As a new group, the postdoc will be expected to take a senior leadership role in directing and designing projects, supporting fellow lab mates and working in a team. The project will also be a interdisciplinary international collaboration and so the candidate must have excellent communication skills and be fluent in oral and written English.

We offer

  • international working environment with communication in English and German
  • interesting career opportunities and a range of opportunities for further qualification and training
  • Compatibility of family and career certified by the workandfamily audit (“berufundfamilie audit”)
  • Support for "New Berliners" through the MDC Welcome & Family Office
  • On-campus health and fitness center

You also benefit from:

  • a remuneration in accordance with the collective agreement for the federal public service (TVöD-Bund), including additional company pension schemes
  • flexible working hours and childcare support
  • an idyllic green campus, which is easily accessible by bicycle, public transport or car
  • a secure job
  • Subsidy for the job ticket as well as discounts in the campus canteen
  • additional health benefits such as flu vaccination, eye test, ergonomics advice at the workplace
  • free use of Nextbike from the Buch S-Bahn station to the campus



Team:


Application Period:
February 29, 2024


Workplace:
MDC Berlin-Mitte


Salary:
Remuneration will be according to the TVöD Bund, depending on the personal requirements, up to the fee group E13


Employment volume:
Full Time
39 hours per week


Desired starting date:
April 01, 2024


Limitation:
Fixed Term
The position is limited to 2 years with the option of an extension.


Contact:
Anna Sonsala
AG Robson


Commitment to Equity, Diversity and Inclusion:
MDC values diversity and is committed to fostering an inclusive, fair and open environment that allows everyone to grow and flourish. All qualified applicants will receive equitable consideration for employment based on their experience and qualifications, and will not be discriminated against on the basis of national or ethnic origin, religion, sexual orientation, gender identity, disability, age, or other personal characteristics. We recognize that creating diverse teams that represent a broad range of experiences, perspectives and backgrounds strengthen our work and research. We welcome applications from open-minded people who embrace working together in a diverse environment. Applications from severely disabled people will be given particular consideration.


Application:
Please use our online portal and submit your application including a cover letter, CV (without photo, age and information about your family status) and other relevant attachments.

If you have a foreign degree, please submit proof of the recognition of your Master's degree in Germany with your application. The proof can be determined via the anabin database (https://anabin.kmk.org/anabin.html) and can be submitted as a PDF attachment to the application.

For information on fair mobility, click here: https://www.fair-labour-mobility.eu/.


Apply now